Parp1

Summary

Gene Symbol: Parp1
Description: poly (ADP-ribose) polymerase family, member 1
Alias: 5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1, ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT 1, NAD(+) ADP-ribosyltransferase 1, msPARP, poly(ADP-ribose) polymerase, poly[ADP-ribose] synthase 1, poly[ADP-ribose] synthetase 1
Species: mouse

Top Publications

  1. ncbi Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
    M J Eliasson
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 3:1089-95. 1997
  2. pmc Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation
    Nirmal K Phulwani
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Neurochem 106:578-90. 2008
  3. pmc Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
    Seong Woon Yu
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:18314-9. 2006
  4. doi Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
    Gad Asher
    Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Cell 142:943-53. 2010
  5. pmc Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
    Mauricio F Farez
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 10:958-64. 2009
  6. pmc Alkylating DNA damage stimulates a regulated form of necrotic cell death
    Wei Xing Zong
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 18:1272-82. 2004
  7. ncbi PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
    Aline Huber
    Unité 9003 du CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, BP 10413, 67412 Illkirch Cedex, France
    DNA Repair (Amst) 3:1103-8. 2004
  8. pmc The roles of PARP1 in gene control and cell differentiation
    Yingbiao Ji
    Epigenetics and Progenitor Cell Program, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Curr Opin Genet Dev 20:512-8. 2010
  9. pmc Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
    J M de Murcia
    Ecole Superieure de Biotechnologie de Strasbourg, UPR 9003 du Centre National de la Recherche Scientifique, Cancerogenese et Mutagenese Moleculaire et Structurale, Boulevard Sebastien Brant, F 67400 Illkirch, France
    Proc Natl Acad Sci U S A 94:7303-7. 1997
  10. pmc SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency
    Yi Shin Lai
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:3772-7. 2012

Research Grants

  1. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
  2. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
  3. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
  4. ADP-Ribose Polymer Metabolism in Spermatogenesis
    Ralph Meyer; Fiscal Year: 2009
  5. Energy dysregulation: The role of AMPK in stroke
    LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2010

Detail Information

Publications180 found, 100 shown here

  1. ncbi Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
    M J Eliasson
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 3:1089-95. 1997
    ..One candidate pathway is DNA damage leading to activation of the nuclear enzyme, poly(ADP-ribose) polymerase (PARP), which catalyzes attachment of ADP ribose units from NAD to nuclear proteins following DNA damage...
  2. pmc Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation
    Nirmal K Phulwani
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Neurochem 106:578-90. 2008
    ..Suppression of Poly (ADP-ribose) polymerase-1 (PARP-1), a DNA repair enzyme, has been shown to attenuate inflammatory responses in several cell types including mixed ..
  3. pmc Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
    Seong Woon Yu
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:18314-9. 2006
    ..is released into the cytoplasm to induce cell death in response to poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation. How PARP-1 activation leads to AIF release is not known...
  4. doi Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
    Gad Asher
    Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Cell 142:943-53. 2010
    ..However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscillates in a daily manner and is regulated by feeding...
  5. pmc Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
    Mauricio F Farez
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 10:958-64. 2009
    ..and astrocytes through a pathway involving Toll-like receptor 2 (TLR2) and poly(ADP-ribose) polymerase 1 (PARP-1)...
  6. pmc Alkylating DNA damage stimulates a regulated form of necrotic cell death
    Wei Xing Zong
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 18:1272-82. 2004
    ..Necrosis in response to DNA damage requires activation of the DNA repair protein poly(ADP-ribose) polymerase (PARP), but PARP activation is not sufficient to determine cell fate...
  7. ncbi PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
    Aline Huber
    Unité 9003 du CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, BP 10413, 67412 Illkirch Cedex, France
    DNA Repair (Amst) 3:1103-8. 2004
    ..b>PARP-1 (113kDa), the founding member, and PARP-2 (62kDa) are both involved in DNA-break sensing and signaling when ..
  8. pmc The roles of PARP1 in gene control and cell differentiation
    Yingbiao Ji
    Epigenetics and Progenitor Cell Program, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Curr Opin Genet Dev 20:512-8. 2010
    ..the chromatin barrier, eukaryotic organisms have evolved the strategy of using poly(ADP-ribose) polymerase 1 (PARP1) to modulate chromatin structure and initiate the steps leading to gene expression control...
  9. pmc Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
    J M de Murcia
    Ecole Superieure de Biotechnologie de Strasbourg, UPR 9003 du Centre National de la Recherche Scientifique, Cancerogenese et Mutagenese Moleculaire et Structurale, Boulevard Sebastien Brant, F 67400 Illkirch, France
    Proc Natl Acad Sci U S A 94:7303-7. 1997
    Poly(ADP-ribose) polymerase [PARP; NAD+ ADP-ribosyltransferase; NAD+: poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2...
  10. pmc SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency
    Yi Shin Lai
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:3772-7. 2012
    ..One protein in the complex was poly ADP-ribose polymerase I (Parp1). The results presented below demonstrate that Parp1 regulates Sox2 protein activity...
  11. pmc Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis
    Rana S Moubarak
    Apoptose et Systeme Immunitaire, CNRS URA 1961, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Mol Cell Biol 27:4844-62. 2007
    Alkylating DNA damage induces a necrotic type of programmed cell death through the poly(ADP-ribose) polymerases (PARP) and apoptosis-inducing factor (AIF)...
  12. ncbi Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
    Seong Woon Yu
    Department of Neurology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Science 297:259-63. 2002
    Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network...
  13. ncbi Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation
    K Erdélyi
    Department of Medical Chemistry, Research Center for Molecular Medicine, University of Debrecen, Bem tér 18 B, 4026 Debrecen, Hungary
    Cell Mol Life Sci 62:751-9. 2005
    b>PARP-1 is a nuclear enzyme activated by DNA breaks. Activated PARP-1 cleaves NAD into nicotinamide and ADP-ribose and polymerizes the latter covalently coupled to nuclear acceptor proteins...
  14. ncbi Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse
    Francois Paquet-Durand
    Department of Ophthalmology, Lund University, 22185 Lund, Sweden
    J Neurosci 27:10311-9. 2007
    ..Excessive activation of the enzyme poly(ADP-ribose) polymerase (PARP) has recently been shown to be involved in several neuropathologies...
  15. ncbi Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase
    Y Le Rhun
    Laboratory for Skin Research, Hospital Research Center for University Laval, CHUL Research Center of CHUQ, Quebec, Quebec, G1V 4G2, Canada
    Biochem Biophys Res Commun 245:1-10. 1998
    Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is catalytically activated by DNA strand interruptions...
  16. pmc Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation
    Mohammad B Hossain
    Department of Biochemistry and Molecular Biology, Genes and Development Program of the Graduate School of Biomedical Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:8621-32. 2009
    ..We show here that NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex...
  17. ncbi Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1
    Josée Lavoie
    Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, CHUQ, Quebec, Canada
    Cancer Genet Cytogenet 156:134-43. 2005
    To determine whether the mouse Werner syndrome homologue (Wrn) and the poly (ADP-ribose) polymerase-1 (PARP-1) enzymes act in concert to prevent specific chromosomal rearrangements, mice with a mutation in the helicase domain of the Wrn ..
  18. pmc The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element
    Susanna Cogoi
    Department of Biomedical Science and Technology, University of Udine, School of Medicine, Piazzale Kolbe 4, 33100 Udine, Italy
    J Biol Chem 285:22003-16. 2010
    ..that this GA-element is bound by the Myc-associated zinc finger (MAZ) and poly(ADP-ribose) polymerase 1 (PARP-1) proteins...
  19. ncbi Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks
    F R Sallmann
    Poly ADP ribose Metabolism Group, Health and Environment Unit, Laval University Medical Research Center, CHUQ, Laval University, Ste Foy, Quebec, G1V 4G2 Canada
    J Biol Chem 275:15504-11. 2000
    Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme that catalyzes the synthesis of poly(ADP-ribose) (pADPr) from its substrate NAD(+) upon binding to DNA strand breaks...
  20. ncbi A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism
    Allen S Mandir
    Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Carnegie 214, Baltimore, MD 21287, USA
    J Neurochem 83:186-92. 2002
    ..p53 is a target of the nuclear enzyme Poly(ADP-ribose)polymerase (PARP), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (..
  21. ncbi Poly(ADP-ribose) polymerase-1 (PARP-1) is required in murine cell lines for base excision repair of oxidative DNA damage in the absence of DNA polymerase beta
    Florence Le Page
    Commissariat a l Energie Atomique CEA, Direction des Sciences du Vivant, Departement de Radiobiologie et Radiopathologie, Unité Mixte de Recherche 217 CNRS CEA Radiobiologie Moléculaire et Cellulaire, 92265 Fontenay aux Roses, France
    J Biol Chem 278:18471-7. 2003
    ..8-oxoG) in vivo using wild-type, polymerase beta(-/-) (Polbeta(-/-)), poly(ADP-ribose) polymerase-1(-/-) (PARP-1(-/-)), and Polbeta(-/-)PARP-1(-/-) 3T3 cell lines...
  22. ncbi Expression of adhesion molecular proteins in the cochlear lateral wall of normal and PARP-1 mutant mice
    Xiaorui Shi
    Oregon Hearing Research Center NRC04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC04, Portland, OR 97239 3098, USA
    Hear Res 224:1-14. 2007
    ..Using immunohistochemistry and poly (ADP-ribose) polymerase-1 (PARP-1) mutant mice, we tested whether PARP-1 contributes to loud-sound induced cochlear lateral wall damage by ..
  23. ncbi Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Cancer 43:2124-33. 2007
    Poly(ADP-ribose) polymerase (PARP)-1 has recently been shown to promote tumour progression...
  24. doi A caveat in mouse genetic engineering: ectopic gene targeting in ES cells by bidirectional extension of the homology arms of a gene replacement vector carrying human PARP-1
    Aswin Mangerich
    Molecular Toxicology Group, Department of Biology, University of Konstanz, Box X911, 78457, Constance, Germany
    Transgenic Res 18:261-79. 2009
    ..an approach to generate a knock-in mouse model using an 'ends-out' gene replacement vector to substitute the murine Parp-1 (mParp-1) coding sequence (32 kb) with its human orthologous sequence (46 kb)...
  25. pmc PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis
    Vimal Selvaraj
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Biol Chem 284:26070-84. 2009
    Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood...
  26. pmc Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress
    Chetan P Hans
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 4:e7430. 2009
    The aims of this study were to investigate the role of poly(ADP-ribose) polymerase (PARP)-1 in dyslipidemia-associated vascular dysfunction as well as autonomic nervous system dysregulation...
  27. pmc Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD
    Jae Woong Hwang
    Department of Environmental Medicine, University of Rochester Medical Center, NY, USA
    Arch Biochem Biophys 500:203-9. 2010
    ..Inhibition of poly(ADP-ribose)-polymerase-1 (PARP-1) attenuated CS-induced autophagy via SIRT1 activation...
  28. doi Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities
    Louis Charles Levros
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, and Centre BioMed, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Biochim Biophys Acta 1803:1062-71. 2010
    ..In this study, we show that Parp-1, HnRNP-U, CBF-A, BUB-3, Kif4, APEX-1 and Ifi204 bind these regulatory elements of the apoD promoter...
  29. pmc Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Biochim Biophys Acta 1802:1020-7. 2010
    Poly(ADP-ribose)polymerase (PARP) inhibitors prevent or alleviate diabetic nephropathy. This study evaluated the role for PARP-1 in diabetic kidney disease using the PARP-1-deficient mouse...
  30. ncbi Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration
    Christopher Runyan
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 133:4861-9. 2006
    ..These data show first that changing expression of Steel factor is required for normal midline germ cell death, and second, that Steel factor is required for normal proliferation and migration of germ cells...
  31. ncbi Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers
    W M Shieh
    Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40506 0286, USA
    J Biol Chem 273:30069-72. 1998
    Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated in response to DNA strand breaks and functions in the maintenance of genomic integrity...
  32. pmc Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice
    F J Oliver
    UPR 9003 du Centre National de la Recherche Scientifique, Cancerogenese et Mutagenese Moleculaire et Structurale, Laboratoire Conventionné du Commissariat à l Energie Atomique, Ecole Supérieure de Biotechnologie de Strasbo
    EMBO J 18:4446-54. 1999
    ..Here we show that PARP-1-deficient cells are defective in NF-kappaB-dependent transcription activation, but not in its nuclear ..
  33. ncbi PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
    Cynthia M Simbulan-Rosenthal
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Oncogene 22:8460-71. 2003
    ..We earlier demonstrated a pivotal role for poly(ADP-ribose) polymerase-1 (PARP-1) in the regulation of E2F-1 expression and promoter activity during S-phase re-entry when quiescent cells re-..
  34. ncbi Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death
    Julie K Horton
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    DNA Repair (Amst) 4:1111-20. 2005
    The activity of poly(ADP-ribose) polymerase (PARP) is highly stimulated following DNA damage resulting in formation of DNA nicks and strand breaks...
  35. ncbi Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis
    B Zingarelli
    Division of Critical Care, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Gastroenterology 116:335-45. 1999
    ..The aim of the present study was to examine the in vivo relevance of this injury pathway...
  36. ncbi Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury
    Z Yang
    Children s Hospital Medical Center, Division of Critical Care, Cincinnati, OH 45229, USA
    Shock 13:60-6. 2000
    ..These findings provide direct evidence that PARS activation participates in the development of delayed cell injury and delayed mediator production in myocardial reperfusion injury...
  37. ncbi Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
    S Shall
    UPR 9003 du Centre National de la Recherche Scientifique, Laboratoire conventionné avec le Commissariat à l Energie Atomique, Ecole Superieure de Biotechnologie de Strasbourg, France
    Mutat Res 460:1-15. 2000
    Poly (ADP-ribose) polymerase (113 kDa; PARP-1) is a constitutive factor of the DNA damage surveillance network developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents...
  38. pmc Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
    C Conde
    UPR 9003 du CNRS, Laboratoire conventionné avec le Commissariat à l Energie Atomique, Ecole Supérieure de Biotechnologie, Universite Louis Pasteur de Strasbourg, Boulevard Sebastien Brant, F 67400 Illkirch, France
    EMBO J 20:3535-43. 2001
    b>PARP-1-deficient mice display a severe defect in the base excision repair pathway leading to radiosensitivity and genomic instability...
  39. pmc Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia
    Hyo Chol Ha
    Department of Neuroscience and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:3270-5. 2002
    Poly(ADP-ribose) polymerase-1 (PARP-1, EC ), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair...
  40. ncbi Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury
    Jianfeng Zheng
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Renal Physiol 288:F387-98. 2005
    ..oxygen species (ROS) and the subsequent DNA damage and excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1) have been implicated in the pathogenesis of ischemic injury...
  41. pmc Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
    Immunology 113:509-17. 2004
    Poly(ADP-ribose) polymerase-1 (PARP-1) is activated in response to DNA injury in the nucleus of eukaryotic cells and has been implicated in intestinal barrier dysfunction during inflammatory bowel diseases...
  42. pmc Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction
    Mourad Zerfaoui
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Cell Signal 20:186-94. 2008
    ..cells (SMCs) was sufficient for the expression of VCAM-1, expression of ICAM-1 showed a critical requirement for PARP-1...
  43. doi Poly(ADP-ribosyl)ation is implicated in the G0-G1 transition of resting cells
    M Carbone
    Pasteur Institute Fondazione Cenci Bolognetti, Department of Cellular Biotechnology and Haematology, University of Rome La Sapienza, Rome, Italy
    Oncogene 27:6083-92. 2008
    ..We show that PARP activity is involved in this step through the regulation of immediate-early response genes, such as c-Fos and c-Myc...
  44. pmc PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation
    Furong Gao
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences Shanghai JiaoTong University School of Medicine, Shanghai 200025, China
    J Biol Chem 284:22263-73. 2009
    ..Here we identify PARP1, a DNA-binding protein with an NAD+-dependent enzymatic activity, as a cofactor of Oct4 and Sox2 to regulate ..
  45. ncbi Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19
    K Hupp
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 143:3787-91. 1989
    ..The close association of the genes for Fc epsilon RI alpha, FC gamma RII, and their shared gamma subunits raises interesting implications regarding coordinate regulation of gene expression...
  46. pmc PARP is important for genomic stability but dispensable in apoptosis
    Z Q Wang
    Research Institute of Molecular Pathology, Vienna, Austria
    Genes Dev 11:2347-58. 1997
    Mice lacking the gene encoding poly(ADP-ribosyl) transferase (PARP or ADPRT) display no phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia and obesity in a mixed genetic background...
  47. ncbi Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated
    Alka Saxena
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Rd, Parkville 3052, Australia
    J Biol Chem 277:26921-6. 2002
    Poly(ADP-ribose) polymerase-1 (PARP-1) is activated by DNA strand breaks during cellular genotoxic stress response and catalyzes poly(ADP-ribosyl)ation of acceptor proteins...
  48. ncbi Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia
    David Martin-Oliva
    University Hospital, San Cecilio, Granada
    Oncogene 23:5275-83. 2004
    Poly (ADP-ribose) polymerase-1 (PARP-1)-deficient mice are protected against septic shock, type I diabetes, stroke and inflammation...
  49. ncbi Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation
    Momchil D Vodenicharov
    Laboratory for Skin Cancer Research, CHUL Research Center CHUQ, Faculty of Medicine, Laval University, 2705, Laurier Boulevard, Quebec, QC, G1V 4G2, Canada
    J Cell Sci 118:589-99. 2005
    ..is increased by an inhibitor of the DNA damage-activated nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP), hence PARP activation is likely to be associated with cellular responses that suppress carcinogenesis...
  50. pmc Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice
    Samuel Garcia
    Research Laboratory, Hospital Clinico Universitario, Choupana s n, 15706 Santiago de Compostela, Spain
    Arthritis Res Ther 8:R14. 2006
    Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear DNA-binding protein that participates in the regulation of DNA repair and maintenance of genomic integrity...
  51. ncbi Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene
    Zhiyuan Yu
    Department of Internal Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 281:9101-9. 2006
    ..coupled with partial peptide sequencing of the protein bands revealed that poly(ADP-ribose) polymerase isoform 1 (PARP-1) bound the probe in a sequence-specific manner...
  52. ncbi Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
    Ullas Kolthur-Seetharam
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Strasbourg, France
    Cell Cycle 5:873-7. 2006
    ..Here we report that SIRT1 modulates PARP-1 activity upon DNA damage...
  53. pmc PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes
    Jose Yelamos
    Department of Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Murcia, Murcia, Spain
    EMBO J 25:4350-60. 2006
    Poly-(ADP-ribose) polymerase-2 (PARP-2) belongs to a large family of enzymes that synthesize and transfer ADP-ribose polymers to acceptor proteins, modifying their functional properties...
  54. ncbi c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation
    S Zhang
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    Cell Death Differ 14:1001-10. 2007
    ..In this study, poly(ADP-ribose) polymerase-1 (PARP-1), a key DNA repair protein, was readily activated by H(2)O(2) and inhibition of PARP-1 activation by either a ..
  55. ncbi Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase
    Hong Gao
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Room 3985 Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Exp Cell Res 313:984-96. 2007
    ..The involvement of PARP-1 and PARP-2 in responses to DNA damage has been well studied but the involvement of nuclear PARG is less well ..
  56. doi Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Mol Biol 377:668-78. 2008
    ..These results suggest that the cooperative action between PRMT1 and CARM1 is required for NF-kappaB-dependent gene expression...
  57. doi PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress
    Rubén Martínez-Romero
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071 Jaen, Spain
    J Cell Biochem 104:2248-60. 2008
    Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that, once activated by genotoxic agents, modulates the activity of several nuclear proteins including itself...
  58. pmc CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery
    Tiziana Guastafierro
    Department of Cellular Biotechnology and Haematology, University La Sapienza, Piazzale Aldo Moro 5, 00161 Rome, Italy
    J Biol Chem 283:21873-80. 2008
    ..in part on poly(ADP-ribosyl)ation and that ADP-ribose polymers (PARs), both present on poly(ADP-ribosyl)ated PARP-1 and/or protein-free, have an inhibitory effect on Dnmt1 activity...
  59. pmc The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes
    Ben Buelow
    Department of Pediatrics and Immunology, University of Washington, Seattle, Washington 98103, USA
    J Biol Chem 283:24571-83. 2008
    ..currents, and TRPM2-dependent Ca2+ transients; no oxidant-induced activation of TRPM2 channels could be detected in PARP-deficient cells...
  60. doi PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma
    Mirella Tanori
    Section of Toxicology and Biomedical Sciences, Biotechnologies, Agro Industry and Health Protection Department, Ente per le Nuove Tecnologie, l Energia e l Ambiente ENEA, Centro Ricerche Casaccia, 00123 Rome, Italy
    Carcinogenesis 29:1911-9. 2008
    ..Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme that plays a multifunctional role in DNA damage signaling and repair...
  61. pmc PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA
    Kazuto Sugimura
    Department of Life Science, Graduate School of Bioresources, Mie University, Tsu, Mie 514 8507, Japan
    J Cell Biol 183:1203-12. 2008
    Poly-ADP ribose polymerase 1 (PARP-1) is activated by DNA damage and has been implicated in the repair of single-strand breaks (SSBs). Involvement of PARP-1 in other DNA damage responses remains controversial...
  62. pmc Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes
    Feikun Yang
    Department of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania, New Bolton Center, Kennett Square, 19348, USA
    Dev Biol 331:326-38. 2009
    ..Here, we provide novel evidence indicating that lack of PARP-1 function during oogenesis predisposes the female gamete to genome instability...
  63. pmc The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1
    Pengcheng Zhu
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Blood 114:1205-16. 2009
    ..In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5'-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, ..
  64. doi Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes
    Rosy El Ramy
    IREBS FRE3211, ESBS, Bld S Brant, BP10413, 67412, Illkirch, France
    Cell Mol Life Sci 66:3219-34. 2009
    Poly(ADP-ribose) polymerase-1 (Parp-1) and the protein deacetylase SirT1 are two of the most effective NAD(+)-consuming enzymes in the cell with key functions in genome integrity and chromatin-based pathways...
  65. ncbi Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
    Z Q Wang
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Genes Dev 9:509-20. 1995
    ....
  66. ncbi Poly(ADP-ribose) polymerase: a molecular nick-sensor
    G de Murcia
    Institut de Biologie Moleculaire et Cellulaire du Centre National de la Recherche Scientifique, Unité de Cancérogénèse et Mutagénèse Moléculaire et Structurale, Strasbourg, France
    Trends Biochem Sci 19:172-6. 1994
    Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents...
  67. ncbi Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
    T Lindahl
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK
    Trends Biochem Sci 20:405-11. 1995
    There are one million molecules of poly(ADP-ribose) polymerase (PARP) in mammalian cell nuclei and the enzyme is found in most eukaryotes, with the notable exception of yeasts...
  68. ncbi Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
    C Morrison
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 17:479-82. 1997
    Poly(ADP-ribose) polymerase (PARP) and DNA-dependent protein kinase (DNA-PK) are DNA break-activated molecules, Although mice that lack PARP display no gross phenotype and normal DNA excision repair, they exhibit high levels of sister ..
  69. pmc Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication
    F Dantzer
    UPR 9003 du Centre National de la Recherche Scientifique Cancérogenèse et Mutagenèse Moléculaire et Structurale, Laboratoire correspondant du CEA no 14, Ecole Superieure de Biotechnologie de Strasbourg, Illkirch Graffenstaden, France
    Nucleic Acids Res 26:1891-8. 1998
    Poly(ADP-ribose) polymerase (PARP) is an element of the DNA damage surveillance network evolved by eukaryotic cells to cope with numerous environmental and endogenous genotoxic agents...
  70. ncbi A B-cell-specific DNA recombination complex
    T Borggrefe
    Basel Institute for Immunology, Postfach, CH 4005 Basel, Switzerland
    J Biol Chem 273:17025-35. 1998
    ..four of the proteins in the SWAP complex: B23 (nucleophosmin), C23 (nucleolin), poly(ADP-ribose) polymerase (PARP), and SWAP-70. The first three are proteins known to be present in most cells...
  71. ncbi Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
    V Burkart
    Diabetes Research Institute at the Heinrich Heine University Dusseldorf, Germany
    Nat Med 5:314-9. 1999
    ..Here we show that mice with a disrupted gene coding for poly (ADP-ribose) polymerase (PARP-/- mice) are completely resistant to the development of diabetes induced by the beta-cell toxin streptozocin...
  72. ncbi A dual approach in the study of poly (ADP-ribose) polymerase: in vitro random mutagenesis and generation of deficient mice
    C Trucco
    Ecole Superieure de Biotechnologie de Strasbourg, UPR 9003 du Centre National de la Recherche Scientifique Cancérogenèse et Mutagenèse Moléculaire et Structurale, Illkirch Graffenstaden, France
    Mol Cell Biochem 193:53-60. 1999
    A dual approach to the study of poly (ADP-ribose)polymerase (PARP) in terms of its structure and function has been developed in our laboratory...
  73. ncbi PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
    J C Ame
    UPR 9003 du CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, F 67400 Illkirch, France
    J Biol Chem 274:17860-8. 1999
    ..Poly(ADP-ribose) polymerase which we will now call PARP-1, has been the only known enzyme of this type for over 30 years...
  74. ncbi Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
    F d'Adda di Fagagna
    Wellcome CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nat Genet 23:76-80. 1999
    ..Studies on the effects of the disruption of the gene encoding PARP (Adprt1, formerly Adprp) in mice have demonstrated roles for PARP in recovery from DNA damage and in suppressing ..
  75. pmc Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
    J Ménisser-de Murcia
    Ecole Superieure de Biotechnologie de Strasbourg, UPR 9003 du CNRS, Cancerogenese et Mutagenese Moleculaire et Structurale, 67400 Illkirch Cedex, France
    Mol Cell Biol 21:1828-32. 2001
    b>PARP-1 and ATM are both involved in the response to DNA strand breaks, resulting in induction of a signaling network responsible for DNA surveillance, cellular recovery, and cell survival...
  76. pmc Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability
    E Samper
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, E 28049 Madrid, Spain
    J Cell Biol 154:49-60. 2001
    Poly(ADP-ribose) polymerase (PARP)-1, a detector of single-strand breaks, plays a key role in the cellular response to DNA damage...
  77. ncbi Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1
    Valerie Schreiber
    UPR 9003 du Centre National de la Recherche Scientifique, Laboratoire conventionné avec le Commissariat à l Energie Atomique, Universite Louis Pasteur, Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France
    J Biol Chem 277:23028-36. 2002
    The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection...
  78. ncbi Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts
    Teresa L Andreone
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 170:2113-20. 2003
    Poly(ADP-ribose) polymerase (PARP)-1 is activated in response to DNA injury in the nucleus of eukaryotic cells and has been implicated in cell dysfunction in inflammation...
  79. ncbi Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma
    A Hamid Boulares
    Department of Biochemistry and Molecular Biology, Lung Laboratory, Georgetown University School of Medicine, Washington, District of Columbia, USA
    Am J Respir Cell Mol Biol 28:322-9. 2003
    ..to inflammation by damaging DNA, which, in turn, results in the activation of poly(ADP-ribose) polymerase-1 (PARP-1) and depletion of its substrate, nicotinamide adenine dinucleotide...
  80. pmc Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
    Josiane Menissier de Murcia
    Unité 9003 du CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, BP 10413, 67412 Illkirch Cedex, France
    EMBO J 22:2255-63. 2003
    The DNA damage-dependent poly(ADP-ribose) polymerases, PARP-1 and PARP-2, homo- and heterodimerize and are both involved in the base excision repair (BER) pathway...
  81. ncbi Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1
    Philippe Garnier
    Department of Neurology, University of California at San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 23:7967-73. 2003
    ..Poly(ADP-ribose) polymerase-1 (PARP-1) normally functions in DNA repair, but extensive PARP-1 activation is a major cause of ischemic cell death...
  82. ncbi Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 278:45145-53. 2003
    ..that NF-kappaB-dependent gene expression was inhibited by E1A in poly(ADP)-ribose polymerase-1 knock out (PARP-1 (-/-)) cells complemented with wild type PARP-1 after tumor necrosis factor alpha (TNFalpha) or ..
  83. pmc Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells
    Ana Carrillo
    Transplant Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Nucleic Acids Res 32:757-66. 2004
    Poly(ADP-ribose) polymerase-1 (PARP-1) has been involved in endothelial cell dysfunction associated with various pathophysiological conditions...
  84. ncbi Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition
    Conrad C Alano
    Department of Neurology, University of California, San Francisco and the Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 279:18895-902. 2004
    Extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) by DNA damage is a major cause of caspase-independent cell death in ischemia and inflammation...
  85. ncbi Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
    Yun gui Yang
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69008, France
    Oncogene 23:3872-82. 2004
    Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant DNA end-sensing and binding molecule...
  86. ncbi Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells
    Hidemitsu Nakajima
    Pharmaceutical Research Center, Meiji Seika Kaisha Limited, 760 Moro oka cho, Kohoku Ku, Yokohama 222 8567, Japan
    J Biol Chem 279:42774-86. 2004
    Synthesis of ADP-ribose polymers catalyzed by poly-(ADP-ribose) polymerase-1 (PARP-1) has been implicated in transcriptional regulation...
  87. pmc Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice
    Virginie Petrilli
    International Agency for Research on Cancer, 69008 Lyons, France
    J Clin Invest 114:1072-81. 2004
    ..is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1)...
  88. ncbi Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    Marc Audebert
    Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, F 31077 Toulouse cedex, France
    J Biol Chem 279:55117-26. 2004
    ..of DNA-PK-proficient and -deficient rodent cells with an inhibitor of the poly(ADP-ribose) polymerase-1 enzyme (PARP-1) led to increased cytotoxicity of the highly efficient DNA double-strand breaking compound calicheamicin gamma1...
  89. ncbi PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli
    Véronique S Meder
    UPR 9003 du Centre National de la Recherche Scientifique, Laboratoire conventionné avec le Commissariat à l Energie Atomique, Universite Louis Pasteur, Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France
    J Cell Sci 118:211-22. 2005
    The DNA damage-dependent poly(ADP-ribose) polymerases-1 and -2 (PARP-1 and PARP-2) are survival factors that share overlapping functions in the detection, signaling and repair of DNA strand breaks resulting from genotoxic lesions in ..
  90. ncbi Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death
    Tiina M Kauppinen
    Department of Neurology, University of California, and Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Immunol 174:2288-96. 2005
    ..Microglial activation is regulated in part by NF-kappaB, and the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) enhances NF-kappaB binding to DNA...
  91. ncbi Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure
    Julie K Horton
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:15773-85. 2005
    ..to the cytotoxic effects of MMS by 4-amino-1,8-naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity...
  92. ncbi In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1
    François Deschênes
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Canada
    Hum Mol Genet 14:3293-308. 2005
    ..The poly(ADP-ribose) polymerase-1 (PARP-1) enzyme is also involved in DNA repair and is known to affect transcription of several genes...
  93. ncbi Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 280:40450-64. 2005
    Poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear factor kappaB (NF-kappaB) have both been demonstrated to play a pathophysiological role in a number of inflammatory disorders...
  94. ncbi Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5
    Mustapha Oumouna
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    J Immunol 177:6489-96. 2006
    We recently used a murine model of allergic airway inflammation to show that poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in the pathogenesis of asthma-related lung inflammation...
  95. pmc Poly(ADP-ribose) (PAR) polymer is a death signal
    Shaida A Andrabi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:18308-13. 2006
    Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays a prominent role in various of models of cellular injury...
  96. ncbi Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death
    Karine Oumouna-Benachour
    Louisiana State University Health Sciences Center, Department of Pharmacology, 1901 Perdido St, New Orleans, LA 70112, USA
    Circulation 115:2442-50. 2007
    Poly(ADP-ribose) polymerase (PARP) was suggested to play a role in endothelial dysfunction that is associated with a number of cardiovascular diseases...
  97. pmc Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells
    Oliver Mortusewicz
    Munich Center for Integrated Protein Science CiPS, Ludwig Maximilians University Munich, 82152 Planegg Martinsried, Germany
    Nucleic Acids Res 35:7665-75. 2007
    ..microirradiation and live cell microscopy we found that the DNA-damage dependent poly(ADP-ribose) polymerases (PARP) PARP-1 and PARP-2 are recruited to DNA damage sites, however, with different kinetics and roles...
  98. ncbi Poly(adp-ribose) polymerase-1 regulates Tracp gene promoter activity during RANKL-induced osteoclastogenesis
    Guillaume E Beranger
    GEPITOS, université Nice Sophia Antipolis, CNRS, Nice, France
    J Bone Miner Res 23:564-71. 2008
    ..Using the mouse osteoclastic model RAW264.7, we studied Tracp gene expression, and we identified PARP-1 as a transcriptional repressor negatively regulated by RANKL during osteoclastogenesis.
  99. ncbi PARP1 is required for adhesion molecule expression in atherogenesis
    Tobias von Lukowicz
    Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiology, Cardiovascular Center, University Hospital Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland
    Cardiovasc Res 78:158-66. 2008
    ..However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme, which plays a role in acute inflammatory diseases.
  100. doi Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability
    Chetan P Hans
    Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Cardiovasc Res 78:429-39. 2008
    ..approaches to examine the individual responses of vascular cells to varying inflammatory factors in order to gain insights on the mechanism(s) by which poly(ADP-ribose) polymerase (PARP) inhibition promotes factors of plaque stability.
  101. doi Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia
    A S Naura
    Louisiana State University Health Sciences Center, Dept of Pharmacology and Experimental Therapeutics, 1901 Perdido St, New Orleans, LA 70112, USA
    Eur Respir J 33:252-62. 2009
    ..iNOS in ovalbumin-induced eosinophilia from the perspective of its relationship with poly(ADP-ribose) polymerase-1 (PARP-1) and oxidative DNA damage. A mouse model of ovalbumin-induced eosinophilia was used to conduct the studies...

Research Grants5

  1. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  2. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..One of the consequences of oxidative injury is activation of the nuclear enzyme, poly(ADP-ribose) polymerase (PARP)...
  3. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..The SPECIFIC AIMS are 1) to evaluate FP15 on oxidative/nitrosative stress and poly(ADP-ribose) polymerase-1 (PARP-1) activation in peripheral nerve in STZ-diabetic rats and high glucose-exposed human endothelial and Schwann cells;..
  4. ADP-Ribose Polymer Metabolism in Spermatogenesis
    Ralph Meyer; Fiscal Year: 2009
    ..The objective of the proposed project is to identify mechanisms of PARP-1, PARC and poly (ADP-ribose) function in postmeiotic germ cell maturation and to define the impact of ADP-ribose ..
  5. Energy dysregulation: The role of AMPK in stroke
    LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2010
    ..A multi-faceted approach is clearly needed to develop efficacious neuroprotective agents that will benefit stroke patients. Manipulation of AMPK levels represents a novel approach to neuroprotection. ..