Pard3

Summary

Gene Symbol: Pard3
Description: par-3 family cell polarity regulator
Alias: AA960621, AI256638, Asip, D8Ertd580e, Par-3, Par3, Pard-3, Pard3a, Phip, partitioning defective 3 homolog, atypical PKC isotype-specific-interacting protein, ephrin-interacting protein, par-3 (partitioning defective 3) homolog
Species: mouse

Top Publications

  1. pmc Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    Development 138:1395-407. 2011
  2. ncbi PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains
    Tomonori Hirose
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Yokohama 236 0004, Japan
    Development 133:1389-98. 2006
  3. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
  4. pmc Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion
    Bin Xue
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Cell Biol 15:189-200. 2013
  5. pmc Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis
    Luke Martin McCaffrey
    Rosalind and Morris Goodman Cancer Research Centre, Department of Oncology, McGill University, Montreal H3A 1A3, Canada
    Cancer Cell 22:601-14. 2012
  6. doi Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis
    Sandra Iden
    Division of Cell Biology I, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 22:389-403. 2012
  7. ncbi The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity
    D Michiel Pegtel
    The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Biol 17:1623-34. 2007
  8. ncbi Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex
    Marcos R Costa
    GSF National Research Institute for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstr 1, 85764, Neuherberg Munich, Germany
    Development 135:11-22. 2008
  9. pmc SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
    Helen B Pearson
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Clin Invest 121:4257-67. 2011
  10. ncbi Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina
    Chieko Koike
    Department of Developmental Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 25:10290-8. 2005

Patents

  1. ASIP-related proteins

Scientific Experts

  • Basile Tarchini
  • Luke Martin McCaffrey
  • Seo Hee Cho
  • Dmitri Chilov
  • Ahmed H K El-Hashash
  • Junichi Ikenouchi
  • JONAH CHAN
  • Thomas Theil
  • Xinyu Chen
  • PAUL R BRAKEMAN
  • Dennis R Warner
  • Shigeo Ohno
  • Tomonori Hirose
  • Kazunori Akimoto
  • Joaquim Grego-Bessa
  • Sandra Iden
  • Atsushi Suzuki
  • Björn Hartleben
  • Ondine Cleaver
  • Tetsuo Noda
  • Tomoyuki Yamanaka
  • Keiko Mizuno
  • Magdalena Gotz
  • Gerd Walz
  • Jacobus J Dudok
  • Leilani Marty-Santos
  • Pei Shan Wang
  • Kathryn V Anderson
  • Jin Young Kim
  • Raanan Greenman
  • Bernhard Schermer
  • Salah Elias
  • Mariyam Murtaza
  • Jan Wijnholds
  • Yoshimi Takai
  • Terunobu Fukuda
  • Masanori Nakayama
  • Bin Xue
  • Jerome Ezan
  • Andre Le Bivic
  • Zhufeng Yang
  • Maddalena Castelli
  • Seong il Lee
  • Celso Henrique Alves
  • Carsten Schnatwinkel
  • Silvia Cappello
  • Amel Kechad
  • Fumiyasu Imai
  • Bruno Cadot
  • Cord Brakebusch
  • Jolanda van Hengel
  • Hunki Paek
  • Helen B Pearson
  • Brian G Rash
  • Dominik Herzog
  • Jarmila Lakomá
  • Takashi Ishiuchi
  • Maki Asami
  • Ke Xu
  • Joao B Relvas
  • Diana C Chong
  • Ueli Suter
  • Nicholas D Poulson
  • Tobias B Huber
  • Jean M Hebert
  • Alethia Villasenor
  • Weili Cong
  • Andrew B Gladden
  • Murat Ozcelik
  • Mingfu Wu
  • Jakub K Famulski
  • Ann C Zovein
  • Joanna Smeeton
  • Reinhard Fassler
  • Dontscho Kerjaschki
  • Roberta Sottocornola
  • Timm Schroeder
  • John G Collard
  • Ronald S Bultje
  • Jan Schmoranzer
  • Wenfei Kang
  • Yuki Sugiyama
  • Sung Ji Yun
  • Yosuke Horikoshi
  • Julie A Siegenthaler
  • Jill M Weimer
  • D Lin
  • Biplab Dasgupta
  • Song Hai Shi
  • Tony Pawson

Detail Information

Publications91

  1. pmc Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    Development 138:1395-407. 2011
    ..Indeed, genetic activation of Notch partially rescues Eya1(-/-) lung epithelial defects. These findings uncover novel functions for Eya1 as a crucial regulator of the complex behavior of distal embryonic lung epithelium...
  2. ncbi PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains
    Tomonori Hirose
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Yokohama 236 0004, Japan
    Development 133:1389-98. 2006
    ..We show that the targeted disruption of the mouse Par3 gene results in midgestational embryonic lethality with defective epicardial development...
  3. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
    ..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions...
  4. pmc Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion
    Bin Xue
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Cell Biol 15:189-200. 2013
    ..We report that partitioning defective protein 3 (Par3) is dysregulated in metastasis in human breast cancer, and is associated with a higher tumour grade and ErbB2-..
  5. pmc Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis
    Luke Martin McCaffrey
    Rosalind and Morris Goodman Cancer Research Centre, Department of Oncology, McGill University, Montreal H3A 1A3, Canada
    Cancer Cell 22:601-14. 2012
    ..To address this issue, we depleted the Par3 polarity gene by RNAi in combination with oncogenic Notch or Ras(61L) expression in the murine mammary gland...
  6. doi Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis
    Sandra Iden
    Division of Cell Biology I, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 22:389-403. 2012
    ..In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth...
  7. ncbi The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity
    D Michiel Pegtel
    The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Biol 17:1623-34. 2007
    ..The Par polarity complex consisting of Par3, Par6, and PKCzeta, in conjunction with Tiam1-mediated Rac signaling, controls apical-basal cell polarity in ..
  8. ncbi Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex
    Marcos R Costa
    GSF National Research Institute for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstr 1, 85764, Neuherberg Munich, Germany
    Development 135:11-22. 2008
    ..Par3 (Pard3) loss-of-function led to premature cell cycle exit, reflected in reduced clone size in vitro and the restriction ..
  9. pmc SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
    Helen B Pearson
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Clin Invest 121:4257-67. 2011
    ..These data suggest that the polarity network could provide a new avenue for therapeutic intervention...
  10. ncbi Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina
    Chieko Koike
    Department of Developmental Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 25:10290-8. 2005
    ..Our data suggest that properly polarized photoreceptors anchor progenitors at the apical edge of the neural retina, which may be essential for building correct laminar organization of the retina...
  11. pmc Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity
    Björn Hartleben
    Renal Division, University Hospital Freiburg, D 79106 Freiburg, Germany
    J Biol Chem 283:23033-8. 2008
    ..We now identify Par3, Par6, and atypical protein kinase C (aPKC) polarity proteins as novel Neph1-Nephrin-associated proteins...
  12. pmc Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3
    Andreas Traweger
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 105:10402-7. 2008
    ....
  13. pmc A cell polarity protein aPKClambda is required for eye lens formation and growth
    Yuki Sugiyama
    School of Biological and Biomedical Sciences, University of Durham, Durham, UK
    Dev Biol 336:246-56. 2009
    ..These observations indicate that aPKClambda, a regulator of polarity and apical junctions, is required for development of a lens that is the correct size and shape...
  14. pmc An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms
    Tomonori Hirose
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Yokohama, Kanagawa, Japan
    PLoS ONE 4:e4194. 2009
    ..Here, we demonstrate that the PAR3-atypical protein kinase C (aPKC)-PAR6beta cell polarity proteins co-localize to the slit diaphragms with nephrin...
  15. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009
    ..These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex...
  16. pmc Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration
    Jan Schmoranzer
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Curr Biol 19:1065-74. 2009
    ..However, centrosomes are maintained at the cell center during orientation in fibroblasts, suggesting that factors working at sites other than the leading edge may also be involved...
  17. pmc The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis
    Luke Martin McCaffrey
    Department of Microbiology, Center for Cell Signaling, University of Virginia School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 23:1450-60. 2009
    ..Transplantation of Par3-depleted stem/progenitor cells into the mammary fat pad severely disrupted mammary development, and glands were ..
  18. ncbi Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions
    Keiko Mizuno
    Department of Molecular Biology, Yokohama City University School of Medicine, Fuku ura 3 9, Kanazawa Ku, Yokohama 236 0004, Japan
    J Biol Chem 278:31240-50. 2003
    ..These results support the notion that the CR1-mediated self-association of the PAR-3-containing protein complex plays a role during the formation of functional tight junctions...
  19. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3.
  20. ncbi A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
    D Lin
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nat Cell Biol 2:540-7. 2000
    ..In vitro, mPAR-3 acts as a substrate and an inhibitor of aPKC. We conclude that mPAR-3 and mPAR-6 have a scaffolding function, coordinating the activities of several signalling proteins that are implicated in mammalian cell polarity...
  21. pmc The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)
    K Ebnet
    Institute of Cell Biology, ZMBE, University of Muenster, D 48149 Muenster, Germany
    EMBO J 20:3738-48. 2001
    ..Recently, vertebrate orthologues of two of these proteins, ASIP/PAR-3 and PAR-6, were found to form a signalling complex with the small GTPases Cdc42/Rac1 and with atypical ..
  22. pmc Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis
    Maddalena Castelli
    1 Division of Genetics and Cell Biology, Dulbecco Telethon Institute DTI at Dibit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy 2 Ph D Program in Molecular and Cellular Biology, Vita Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy
    Nat Commun 4:2658. 2013
    ..Polycystin-1 associates with Par3 favouring the assembly of a pro-polarizing Par3/aPKC complex and it regulates a programme of cell polarity ..
  23. doi Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities
    Terunobu Fukuda
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Development 141:399-409. 2014
    ..These results indicate that, owing to the loss of Nectin-3, hair cells contact each other inappropriately and form abnormal junctions, ultimately resulting in abnormal hair bundle orientation and morphology. ..
  24. pmc Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains
    Tomoyuki Yamanaka
    Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 8:e84036. 2013
    ..Thus, despite the polarity complex disruption, neuronal deletion of aPKCλ does not induce obvious cell loss or disorientation in mouse brains after cell differentiation. ..
  25. pmc Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye
    Jin Young Kim
    Shriners Hospitals Pediatric Research Center and Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Gene Expr Patterns 17:31-7. 2015
    ..These findings suggest that core Crumbs polarity complex proteins exert common and independent functions depending on cellular context...
  26. pmc Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains
    Joaquim Grego-Bessa
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Development 142:1305-14. 2015
    ..The basal accumulation of F-actin is associated with the assembly of ectopic basal tight junctions and focal disruptions of the basement membrane, which eventually lead to a breakdown of epithelial organization...
  27. pmc Crucial roles of the Arp2/3 complex during mammalian corticogenesis
    Pei Shan Wang
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 143:2741-52. 2016
    ..Our data suggest that Arp2/3-mediated actin assembly might be particularly important for neuronal cell motility in a soft or poorly adhesive matrix environment. ..
  28. pmc Non-cell autonomous and non-catalytic activities of ATX in the developing brain
    Raanan Greenman
    Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel
    Front Neurosci 9:53. 2015
    ....
  29. pmc Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC
    Salah Elias
    Institut Curie, Orsay, France CNRS UMR 3306, Orsay, France INSERM U1005, Orsay, France
    PLoS Biol 13:e1002142. 2015
    ..HTT is required for the apical localization of PAR3-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice...
  30. pmc Pdx1 regulates pancreas tubulogenesis and E-cadherin expression
    Leilani Marty-Santos
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 143:101-12. 2016
    ..These findings demonstrate a novel link between regulators of epithelial architecture, specification of pancreatic cell fate and organogenesis. ..
  31. doi Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon
    Jacobus J Dudok
    Department of Neuromedical Genetics, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Neurosci Res 108:12-23. 2016
    ..We show that CRB2 is required for maintenance of the apical polarity complex during development of the cortex and regulation of cell division, and that loss of CRB2 results in cortical abnormalities. ..
  32. doi A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells
    Basile Tarchini
    Cellular Neurobiology Research Unit, Institut de recherches cliniques de Montreal IRCM, Montreal, QC H2W 1R7, Canada Electronic address
    Dev Cell 27:88-102. 2013
    ..Gαi is additionally required for lateral orientation of cochlear hair cells, providing a possible mechanism to couple the emergence of asymmetric stereocilia bundles with planar cell polarity. ..
  33. pmc The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium
    Joaquim Grego-Bessa
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States
    elife 5:e12034. 2016
    ..The data suggest that appropriate levels of membrane-associated PDPK1 are required for stabilization of apical junctions, which promotes cell elongation, during epithelial morphogenesis. ..
  34. pmc Spatial regulation of VEGF receptor endocytosis in angiogenesis
    Masanori Nakayama
    Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Muenster, Faculty of Medicine, D 48149 Muenster, Germany
    Nat Cell Biol 15:249-60. 2013
    ..Our work uncovers how vessel growth is dynamically controlled by local VEGF receptor endocytosis and the activity of cell polarity proteins...
  35. doi Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton
    Jerome Ezan
    1 INSERM, Planar Polarity and Plasticity Group, Neurocentre Magendie, 33077 Bordeaux, France 2 Université Bordeaux, Neurocentre Magendie, Bordeaux 33077, France
    Nat Cell Biol 15:1107-15. 2013
    ..Thus G-protein-dependent signalling controls the migration of the cilium cell autonomously, whereas core PCP signalling controls long-range tissue PCP. ..
  36. doi Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition
    Seong il Lee
    Department of Neurobiology and Behavior and Program in Neuroscience, Stony Brook University, Stony Brook, New York 11794, USA
    J Neurosci 33:2541-54. 2013
    ..NG2 treatment also activates Cdc42, increases the association of Par6 with PKCζ, and leads to a Par3-dependent activation of Rac1...
  37. pmc aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation
    Sandra Iden
    Institute associated Research Group Cell adhesion and cell polarity, University Munster, 48419 Münster, Germany
    J Cell Biol 196:623-39. 2012
    ..Our data suggest that aPKC phosphorylates JAM-A at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification...
  38. doi Reelin sets the pace of neocortical neurogenesis
    Jarmila Lakomá
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de San Juan s n, E 03550 San Juan de Alicante, Spain
    Development 138:5223-34. 2011
    ..These results indicate that reelin and Notch signaling cooperate to set the pace of neocortical neurogenesis, a prerequisite for proper neuronal migration and cortical layering...
  39. pmc Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis
    Seo Hee Cho
    Pediatric Research Center, Department of Pediatrics, University of Texas Health Science Center, Houston TX 77030, USA
    Hum Mol Genet 21:2663-76. 2012
    ..Our data uncover the indispensible role of Pals1 in retinal development, likely involving the maintenance of retinal polarity and survival of retinal neurons, thus providing the basis for the pathologic mechanisms of LCA8...
  40. doi The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex
    Maki Asami
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Development 138:5067-78. 2011
    ..Taken together, our work reveals several direct effects that the transcription factor Pax6 has on the machinery that mediates the orientation and mode of cell division...
  41. doi A radial glia-specific role of RhoA in double cortex formation
    Silvia Cappello
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, 85764 Neuherberg, Germany
    Neuron 73:911-24. 2012
    ..These data not only demonstrate that RhoA is largely dispensable for migration in neurons but also showed that defects in radial glial cells, rather than neurons, can be sufficient to produce SBH...
  42. pmc Role of the polarity protein Scribble for podocyte differentiation and maintenance
    Björn Hartleben
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 7:e36705. 2012
    ....
  43. pmc Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3
    Bruno Cadot
    UMR S 787 INSERM, Universite Pierre et Marie Curie Paris 6, Paris 75634, France
    EMBO Rep 13:741-9. 2012
    ..This movement is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. We found that Par6β and dynactin accumulate at the nuclear envelope of differentiated myoblasts and myotubes, and ..
  44. pmc The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth
    Bernhard Schermer
    Renal Division and 2Children s Hospital, University Hospital Freiburg, 79106 Freiburg, Germany
    J Cell Biol 175:547-54. 2006
    ..Furthermore, pVHL interacts with the Par3-Par6-atypical PKC complex, suggesting a mechanism for linking polarity pathways to microtubule capture and ..
  45. doi Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene
    Celso Henrique Alves
    Department of Neuromedical Genetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Hum Mol Genet 22:35-50. 2013
    ..The data suggest an essential role for CRB2 in proper lamination of the photoreceptor layer and suppression of proliferation of late-born retinal progenitor cells...
  46. pmc Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice
    Carsten Schnatwinkel
    Howard Hughes Medical Institute, Department of Pediatrics, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, Colorado, United States of America
    PLoS ONE 7:e44871. 2012
    ..In addition, Nubp1 mutation disrupts localization of the polarity protein Par3 and the mitosis relevant protein Numb...
  47. pmc SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter
    Norimasa Tamehiro
    Lipid Metabolism Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Biochemistry 47:6138-47. 2008
    ..In composite, these results indicate that the physical interaction of ABCA1 and SPTLC1 results in reduction of ABCA1 activity and that inhibition of this interaction produces enhanced cholesterol efflux...
  48. pmc Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina
    Amel Kechad
    Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Neurosci 32:17197-210. 2012
    ....
  49. pmc De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity
    Zhufeng Yang
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 140:1774-84. 2013
    ..We report that kidney mesenchymal cells contain discrete Par3-expressing membrane microdomains that become restricted to an apical domain, coinciding with lumen formation...
  50. ncbi Gli3 is required for the specification and differentiation of preplate neurons
    Thomas Theil
    Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Dev Biol 286:559-71. 2005
    ....
  51. ncbi The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
    D Lin
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 274:3726-33. 1999
    ..polypeptides with multiple PDZ domains, representing fragments of the molecule GRIP, the protein syntenin, and PHIP, a novel PDZ domain-containing protein related to Caenorhabditis elegans PAR-3...
  52. pmc Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 299:424-37. 2006
    ..The results further imply that retinal lamination and retinal cell differentiation are genetically separable processes...
  53. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  54. ncbi The polarity protein Par-3 directly interacts with p75NTR to regulate myelination
    Jonah R Chan
    Department of Cell and Neurobiology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA
    Science 314:832-6. 2006
    ..Together, these results point to a critical role in the establishment of cell polarity for myelination...
  55. ncbi PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs
    Francesca E Duncan
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
    Dev Biol 280:38-47. 2005
    ..This cortical PAR-3 localization depends on intact microfilaments. These results suggest a role for PAR-3 in establishing asymmetry in the egg and in defining the future site of polar body emission...
  56. ncbi Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, HSC, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 7:262-9. 2005
    ..These results define a critical function for Par-3 in tight junction assembly, and reveal a novel mechanism through which Par-3 engages in the spatial regulation of Rac activity and establishment of epithelial polarity...
  57. ncbi Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo
    Berenika Plusa
    Wellcome Trust and Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    J Cell Sci 118:505-15. 2005
    ..The underlying molecular mechanisms for these events are not understood. As the Par3/aPKC complex has a role in establishing cellular polarity and division orientation in other systems, we explored ..
  58. pmc Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells
    Yoichi Kosodo
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    EMBO J 23:2314-24. 2004
    ..Our results support a novel concept for the cell biological basis of asymmetric, neurogenic divisions of neuroepithelial cells in the mammalian central nervous system...
  59. ncbi Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios
    Andrew G Clark
    Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 302:1960-3. 2003
    ..In addition to suggesting adaptive physiological differences between chimps and humans, human-accelerated genes are significantly more likely to underlie major known Mendelian disorders...
  60. ncbi Identification of three novel Smad binding proteins involved in cell polarity
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    FEBS Lett 539:167-73. 2003
    ....
  61. ncbi Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse
    Kyoji Takekuni
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 278:5497-500. 2003
    ..These results indicate that nectin-1 and -3 are involved in the localization of PAR-3 at AJs in the neuroepithelial cells of the embryonic telencephalon...
  62. ncbi Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
    Naoyuki Manabe
    Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    Dev Dyn 225:61-9. 2002
    ..Here, we explore the localization of atypical PKC isotype-specific interacting protein (ASIP), a mammalian homologue of the Caenorhabditis elegans polarity protein PAR-3, in embryonic neural tissues...
  63. ncbi Assembly of epithelial tight junctions is negatively regulated by Par6
    Lin Gao
    Center for Cell Signaling and Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908 0577, USA
    Curr Biol 12:221-5. 2002
    ..The Par proteins (partitioning-defective) Par3 and Par6, plus atypical protein kinase C (aPKC) function in the formation or maintenance of TJs and more generally ..
  64. ncbi The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1
    A Johansson
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    J Cell Sci 113:3267-75. 2000
    ..These findings, together with the reported roles of PAR-6 and PAR-3 in C. elegans, suggest that Cdc42 and Rac1 and PAR-6/PAR-3 are involved in the establishment of cell polarity in epithelial cells...
  65. doi Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells
    Yosuke Horikoshi
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Cell Sci 122:1595-606. 2009
    ..Therefore, formation of the PAR-3-aPKC-PAR-6 complex might be required for targeting of not only the aPKC-PAR-6 complex but also of apical protein carrier vesicles to primordial junction structures...
  66. pmc Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development
    Joanna Smeeton
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Development 137:3233-43. 2010
    ..p38 MAPK activation was not dependent on the kinase activity of ILK. Thus, we conclude that ILK plays a crucial role in activating p38 MAPK, which regulates cell cycle arrest of epithelial cells in renal tubulogenesis...
  67. pmc AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development
    Biplab Dasgupta
    Department of Pathology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 16:256-70. 2009
    ..The AMPK-Rb axis is utilized by both growth factors and energy restriction to increase NPC growth. Our results reveal that AMPK integrates growth factor signaling with cell cycle control to regulate brain development...
  68. doi Differential regulation of Akt/protein kinase B isoforms during cell cycle progression
    Sung Ji Yun
    MRC for Ischemic Tissue Regeneration and Medical Research Institute, Department of Pharmacology, School of Medicine, Pusan National University, Ami dong 1 ga 10, Seo Gu, Busan 602 739, Republic of Korea
    FEBS Lett 583:685-90. 2009
    ....
  69. pmc MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex
    Jill M Weimer
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 136:2965-75. 2009
    ..of key polarity complexes [CDC42, beta-catenin (CTNNB1), N-cadherin (CDH2), myosin IIB (MYOIIB), aPKCzeta, LGL, PAR3, pericentrin, PROM1] is lost...
  70. pmc Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis
    PAUL R BRAKEMAN
    Division of Pediatric Nephrology, Department of Pediatrics, University of California, Box 0748, San Francisco, California 94143 0748, USA
    Am J Physiol Renal Physiol 296:F564-74. 2009
    ....
  71. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
  72. pmc FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex
    Junichi Ikenouchi
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Proc Natl Acad Sci U S A 107:748-53. 2010
    ..We propose that the Par-3/FRMD4A/cytohesin-1 complex ensures accurate activation of Arf6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization...
  73. pmc Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 18:39-51. 2010
    ..of normally polarized cell-cell adhesion molecules, as well as decreased expression of the polarity gene Par3 (pard3)...
  74. doi Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
    Murat Ozcelik
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:4120-31. 2010
    ..We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function...
  75. doi ASPP2 regulates epithelial cell polarity through the PAR complex
    Weili Cong
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama, Japan
    Curr Biol 20:1408-14. 2010
    ..Our results, taken together with the known functions of ASPP2, suggest a close relationship between cell polarity and other cell regulatory mechanisms mediated by ASPP2...
  76. doi ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development
    Roberta Sottocornola
    Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, UK
    Dev Cell 19:126-37. 2010
    ..These results identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development...
  77. pmc Epicardial spindle orientation controls cell entry into the myocardium
    Mingfu Wu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Dev Cell 19:114-25. 2010
    ..Taken together, these data suggest that directed mitotic spindle orientation contributes to epicardial EMT and implicate a junctional complex of beta-catenin and Numb in the regulation of spindle orientation...
  78. pmc FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis
    Brian G Rash
    Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 31:15604-17. 2011
    ....
  79. pmc The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex
    Andrew B Gladden
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Dev Cell 19:727-39. 2010
    ..Our studies reveal that Merlin can associate directly with α-catenin and link it to Par3, thereby providing an essential link between the AJ and the Par3 polarity complex during junctional maturation.
  80. pmc Robust control of mitotic spindle orientation in the developing epidermis
    Nicholas D Poulson
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 191:915-22. 2010
    ..These data have uncovered two important regulatory points controlling ACD in the epidermis and allow a framework for analysis of how external cues control this important choice...
  81. pmc Epithelial dynamics of pancreatic branching morphogenesis
    Alethia Villasenor
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 137:4295-305. 2010
    ..Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ...
  82. pmc Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit
    Jakub K Famulski
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Science 330:1834-8. 2010
    ..We found that cerebellar granule neuron germinal zone exit is regulated by proteasomal degradation of Pard3A by the Seven in Absentia homolog (Siah) E3 ubiquitin ligase...
  83. pmc Cell polarity and spindle orientation in the distal epithelium of embryonic lung
    Ahmed H El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, California, USA
    Dev Dyn 240:441-5. 2011
    ..These findings provide evidence for polarity in distal epithelial progenitors of embryonic lungs and provide a framework for future translationally oriented studies in this area...
  84. pmc Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling
    Ke Xu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 20:526-39. 2011
    ..Rasipl null angioblasts fail to properly localize the polarity determinant Par3 and display defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion to ..
  85. doi The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool
    Dominik Herzog
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 31:5120-30. 2011
    ..Together, our data show that RhoA signaling is necessary for AJ regulation and for the maintenance of mammalian neuroepithelium organization preventing precocious cell-cycle exit and differentiation...
  86. pmc β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4
    Hunki Paek
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Cell 20:689-99. 2011
    ..Moreover, these antagonistic pathways converge on the transcriptional regulation of apoptosis, and genes such as Cdkn1a, suggesting a mechanism for how signaling centers in the embryonic head regulate cell survival...
  87. doi Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation
    Takashi Ishiuchi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Nat Cell Biol 13:860-6. 2011
    ..Here, we report that Willin (a FERM-domain protein) and Par3 (a polarity-regulating protein) cooperatively regulate ROCK-dependent apical constriction...
  88. doi Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain
    Dmitri Chilov
    Institute of Biotechnology, University of Helsinki, Finland
    Dev Biol 357:259-68. 2011
    ..The results demonstrate a novel function for p-β-cat in maintaining neuroepithelial integrity and suggest that centrosomal p-ß-cat is required to maintain symmetric cleavages and polarity in neural progenitors...
  89. pmc Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice
    Eriko Fujita
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Oawahigashi machi 4 1 1, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 171:1800-10. 2007
    ..The lack of the ternary complex in the Ra175(-/-) elongating spermatid may cause the defect of the specialized adhesion structures, resulting in the oligo-astheno-teratozoospermia...
  90. ncbi The PAR-aPKC system: lessons in polarity
    Atsushi Suzuki
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Cell Sci 119:979-87. 2006
    ....
  91. pmc The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis
    Wenfei Kang
    Departments of Neuroscience and Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 29:14571-80. 2009
    ..The proliferation rate of progenitors themselves, however, is unchanged. These results indicate that FGFs normally repress the radial glia to progenitor cell transition during corticogenesis...

Patents1

  1. ASIP-related proteins
    Patent Number: WO02055706-A2; Date:2002-07-18