Paqr3

Summary

Gene Symbol: Paqr3
Description: progestin and adipoQ receptor family member III
Alias: 6330415A20Rik, AY424292, RKTG, progestin and adipoQ receptor family member 3, Raf kinase trapping to Golgi
Species: mouse

Top Publications

  1. ncbi PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif
    Y Tom Tang
    Biology Research, Nuvelo, Sunnyvale, CA, 94085, USA
    J Mol Evol 61:372-80. 2005
  2. pmc Spatial regulation of Raf kinase signaling by RKTG
    Lin Feng
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 104:14348-53. 2007
  3. doi Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse
    Xiaoduo Xie
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 29:1632-8. 2008
  4. doi PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
    Lingdi Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Endocrinology 154:4525-35. 2013
  5. pmc PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus
    Daqian Xu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 20031, China
    Nat Commun 6:8100. 2015
  6. pmc PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
    Da Qian Xu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    EMBO J 35:496-514. 2016
  7. doi PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai China
    Carcinogenesis 33:2228-35. 2012
  8. pmc PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:444-56. 2013
  9. doi Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition
    Yuhui Jiang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Cancer Res 71:2959-68. 2011

Scientific Experts

  • Yan Chen
  • Yi Pan
  • Xiao Wang
  • Lingdi Wang
  • Zhenzhen Wang
  • Xiaoduo Xie
  • Zheng Wang
  • Lu Zhu
  • Yuhui Jiang
  • Weizhong Liu
  • Da Qian Xu
  • Daqian Xu
  • Feifan Guo
  • Fei Xiao
  • Yong Liu
  • Zhi qiang Ling
  • Fengjuan Fan
  • Yixuan Zhang
  • Lin Feng
  • Y Tom Tang
  • De Yi Zhang
  • Zi Long Zhao
  • Chen Yao Wang
  • Jin Gu
  • Hui da Wan
  • Zhi Gang Li
  • Zhi Fei Wang
  • Zun Ji Ke
  • Lu Jian Liao
  • Yong xian Zhang
  • Kai Yang Man
  • Zhi Xue Liu
  • Yuxue Zhang
  • Wei Jiang
  • Bao Liang Song
  • Walter G Thomas
  • Yongxian Zhang
  • Tingting Xia
  • Zhenghu Li
  • Bin Liu
  • Xuebing Li
  • Guohao Wu
  • Shi Jiao
  • Jing Fang
  • Zhiqiang Ling
  • Zhigang Li
  • Hong Ma
  • Xiaolin Luo
  • Qiurong Ding
  • Jing He
  • Tianhua Hu
  • Matthew Arterburn
  • Peter C Emtage
  • Bryan Boyle
  • Jessica M Bright
  • Walter D Funk

Detail Information

Publications9

  1. ncbi PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif
    Y Tom Tang
    Biology Research, Nuvelo, Sunnyvale, CA, 94085, USA
    J Mol Evol 61:372-80. 2005
    ....
  2. pmc Spatial regulation of Raf kinase signaling by RKTG
    Lin Feng
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 104:14348-53. 2007
    ..Here, we report spatial regulation of Raf kinase by RKTG (Raf kinase trapping to Golgi). RKTG is a seven-transmembrane protein localized at the Golgi apparatus...
  3. doi Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse
    Xiaoduo Xie
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 29:1632-8. 2008
    b>Raf kinase trapping to Golgi (RKTG) is a newly characterized negative regulator of the Ras-Raf-MEK-ERK signaling pathway via sequestrating Raf-1 to the Golgi apparatus...
  4. doi PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
    Lingdi Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Endocrinology 154:4525-35. 2013
    ..b>PAQR3 is a member of the progesterone and AdipoQ receptor (PAQR) family with close homology to adiponectin receptors...
  5. pmc PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus
    Daqian Xu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 20031, China
    Nat Commun 6:8100. 2015
    ..Here we report that a Golgi-localized membrane protein progestin and adipoQ receptors 3 (PAQR3) interacts with Scap and SREBP and tethers them to the Golgi...
  6. pmc PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
    Da Qian Xu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    EMBO J 35:496-514. 2016
    ..Here, we identify that PAQR3 governs the preferential formation and activation of ATG14L-linked VPS34 complex for autophagy initiation via two ..
  7. doi PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai China
    Carcinogenesis 33:2228-35. 2012
    b>PAQR3 is a member of the progestin and adipoQ receptor (PAQR) family and was recently characterized as a spatial regulator that negatively modulates Ras/Raf/MEK/ERK signaling cascade...
  8. pmc PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:444-56. 2013
    ..We demonstrate here a new mode of spatial regulation for the p110α subunit of PI3K by PAQR3 that is exclusively localized in the Golgi apparatus...
  9. doi Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition
    Yuhui Jiang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Cancer Res 71:2959-68. 2011
    b>Raf kinase trapping to Golgi (RKTG) is a potential tumor suppressor gene due to its negative roles in regulating Ras/Raf/MEK/ERK (extracellular signal-regulated kinase) pathway and GPCR (G protein-coupled receptor) Gβγ subunit signaling...