P2rx7

Summary

Gene Symbol: P2rx7
Description: purinergic receptor P2X, ligand-gated ion channel, 7
Alias: AI467586, P2X(7), P2X7R, P2X purinoceptor 7, ATP receptor, P2X7 purinoceptor, P2X7 receptor, P2Z receptor
Species: mouse

Top Publications

  1. ncbi Caveolin-1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells
    K Barth
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Germany
    FEBS J 274:3021-33. 2007
  2. doi Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration
    Miguel Diaz-Hernandez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Campus UAM de Cantoblanco, 28049 Madrid, Spain
    FASEB J 23:1893-906. 2009
  3. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
  4. ncbi Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:18810-8. 2007
  5. ncbi P2X7 receptor-mediated release of excitatory amino acids from astrocytes
    Shumin Duan
    Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 23:1320-8. 2003
  6. pmc Autocrine regulation of T-cell activation by ATP release and P2X7 receptors
    Linda Yip
    Department of Surgery, University of California San Diego, San Diego, California, USA
    FASEB J 23:1685-93. 2009
  7. pmc Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
    Sandra Hubert
    Institut National de la Sante et de la Recherche Medicale, U905, 76183 Rouen, France
    J Exp Med 207:2561-8. 2010
  8. pmc The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products
    James I Elliott
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Arthritis Res Ther 7:R468-75. 2005
  9. ncbi P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways
    Mitsutoshi Tsukimoto
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Immunol 177:2842-50. 2006
  10. ncbi Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
    Lilla Papp
    Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, POB 67, Hungary
    Neuroreport 15:2387-91. 2004

Research Grants

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Caveolin-1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells
    K Barth
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Germany
    FEBS J 274:3021-33. 2007
    The P2X7 receptor has recently been described as a marker for lung alveolar epithelial type I cells...
  2. doi Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration
    Miguel Diaz-Hernandez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Campus UAM de Cantoblanco, 28049 Madrid, Spain
    FASEB J 23:1893-906. 2009
    ..These in vivo data strongly suggest that altered P2X7-receptor level and function contribute to HD pathogenesis and highlight the therapeutic potential of P2X7 receptor antagonists.
  3. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
    ..pneumoniae directly activates the NLRP3/ASC inflammasome, leading to the release of biologically active IL-1beta, and that concurrent IL-1 signaling is required for optimal host defense against acute bacterial pneumonia...
  4. ncbi Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:18810-8. 2007
    ..However, the roles of P2X7 receptor and intracellular K(+) in IL-1beta secretion induced by bacterial infection remain unknown...
  5. ncbi P2X7 receptor-mediated release of excitatory amino acids from astrocytes
    Shumin Duan
    Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 23:1320-8. 2003
    ..ATP produced an inward current in patch-clamped astrocytes with properties characteristic of P2X7 receptor activation: the current was amplified in low divalent cation medium, blocked by pyridoxal phosphate-6-..
  6. pmc Autocrine regulation of T-cell activation by ATP release and P2X7 receptors
    Linda Yip
    Department of Surgery, University of California San Diego, San Diego, California, USA
    FASEB J 23:1685-93. 2009
    ..We conclude that ATP release and autocrine, positive feedback through P2X(7) receptors is required for the effective activation of T cells...
  7. pmc Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
    Sandra Hubert
    Institut National de la Sante et de la Recherche Medicale, U905, 76183 Rouen, France
    J Exp Med 207:2561-8. 2010
    ..2-mediated ADP-ribosylation of the cytolytic P2X7 receptor on T cells. We show that T reg cells express the ART2...
  8. pmc The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products
    James I Elliott
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Arthritis Res Ther 7:R468-75. 2005
    ..P2RX7, respectively, while lymphocytes from these and (NZB x NZW)F1 mice differ markedly in their responses to P2X7 receptor stimulation. NZB mice and NZW mice express functionally distinct alleles of the proinflammatory receptor, P2X7...
  9. ncbi P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways
    Mitsutoshi Tsukimoto
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Immunol 177:2842-50. 2006
    ..In this study, we investigated P2X7 receptor-mediated cell death during murine T cell maturation...
  10. ncbi Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
    Lilla Papp
    Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, POB 67, Hungary
    Neuroreport 15:2387-91. 2004
    ..The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X(7)R...
  11. pmc P2X7 receptor-Pannexin1 complex: pharmacology and signaling
    R Iglesias
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Physiol Cell Physiol 295:C752-60. 2008
    ....
  12. ncbi Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells
    Pei Yu Wu
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan, ROC
    Cell Signal 21:881-91. 2009
    ..Recently, P2X7 receptor has been shown to sustain growth of human neuroblastoma cells but its role during neuronal differentiation ..
  13. pmc Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival
    R Glas
    Department of Medicine, Larry L Hillblom Islet Research Center, UCLA, Los Angeles, CA, USA
    Diabetologia 52:1579-88. 2009
    ..In the present study, we hypothesise the regulation of IL-1Ra secretion by purinergic P2X(7) receptors in islets...
  14. ncbi P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid
    Nattapon Panupinthu
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada
    J Biol Chem 282:3403-12. 2007
    ..Disruption of the gene encoding the P2X7 receptor leads to decreased periosteal bone formation and insensitivity of the skeleton to mechanical stimulation...
  15. pmc Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice
    Yi Guang Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 186:4278-84. 2011
    Although P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined...
  16. ncbi Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes
    Lanfen Chen
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 176:3115-26. 2006
    The purinergic receptor P2X7R is a nucleotide-gated ion channel that has been proposed to function as a major regulator of inflammation...
  17. ncbi P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, United Kingdom
    J Immunol 180:7147-57. 2008
    ..None of these release responses were associated with cell damage or cytolytic effects. This provides the first direct demonstration of a distinct signaling mechanism responsible for ATP-induced release of pro-IL-1beta...
  18. pmc Regulation by P2X7: epithelial migration and stromal organization in the cornea
    Courtney Mayo
    Departments of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 49:4384-91. 2008
    ..The goal here was to characterize the role of the P2X(7) receptor in the repair of in vivo corneal epithelial debridement wounds and in the structural organization of the corneal stroma...
  19. ncbi The P2X7 nucleotide receptor mediates skeletal mechanotransduction
    Jiliang Li
    Department of Anatomy and Cell Biology and Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:42952-9. 2005
    The P2X7 nucleotide receptor (P2X7R) is an ATP-gated ion channel expressed in many cell types including osteoblasts and osteocytes...
  20. ncbi P2X7 receptors regulate NKT cells in autoimmune hepatitis
    Hiroki Kawamura
    Departments of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, 90033, USA
    J Immunol 176:2152-60. 2006
    ..These results prompt the conclusion that engagement of P2X(7)Rs on NKT cells inhibits naive, while stimulating activated cells, resulting in suppression or stimulation of autoimmune hepatitis...
  21. ncbi Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors
    Dong Jae Jun
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Nam Gu, Pohang, Republic of Korea
    J Biol Chem 282:37350-8. 2007
    ..Therefore, extracellular ATP release from injured tissues may act as an accelerating factor in necrotic SN4741 dopaminergic cell death via P2X(7)Rs...
  22. doi Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons
    Miguel Diaz-Hernandez
    Departamento de Bioquimica y Biologia Molecular IV, Facultad de Veterinaria, UCM, 28040 Madrid, Spain
    J Cell Sci 121:3717-28. 2008
    ..This effect is mediated by the P2X7 receptor, which is present in the growth cone of the axon...
  23. doi P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema
    Monica Lucattelli
    Department of Pulmonary Medicine, University of Freiburg, Germany
    Am J Respir Cell Mol Biol 44:423-9. 2011
    ..Our objective was to investigate the functional role of the ATP receptor P2X(7) in the pathogenesis of cigarette smoke (CS)-induced lung inflammation and emphysema in vivo...
  24. ncbi Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism
    A Sikora
    Department of Microbiology and Immunology, The Howard Hughes Medical Institute, Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 163:558-61. 1999
    ....
  25. ncbi P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release
    Philip A Verhoef
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 170:5728-38. 2003
    In response to ATP binding, the P2X7R facilitates cation channel activation, nonspecific pore formation, rapid changes in plasma membrane morphology, and secretion of IL-1 beta from LPS-primed macrophages...
  26. ncbi Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release
    J Michelle Kahlenberg
    Dept of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Physiol Cell Physiol 286:C1100-8. 2004
    ....
  27. ncbi P2X7-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms
    M F Ireland
    School of Biomedical Sciences, The University of Queensland, Brisbane, 4072, Australia
    Neuroscience 128:269-80. 2004
    Recent studies demonstrate that P2X7 receptor subunits (P2X7RS) are present at central and peripheral synapses and suggest that P2X7RS can regulate transmitter release...
  28. ncbi P2X7 receptor-dependent ATP-induced shedding of CD27 in mouse lymphocytes
    Hana Moon
    Laboratory of Immunopathology, Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, Republic of Korea
    Immunol Lett 102:98-105. 2006
    ..the T and B cells, is released rapidly upon treatment with low ATP concentrations, via the activation of the P2X7 receptor. The surface expression of CD27 on the T and B cells has been shown to be down-regulated as the result of ATP ..
  29. ncbi Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor
    Philip A Verhoef
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Immunol 175:7623-34. 2005
    The P2X7 receptor (P2X7R) is an ATP-gated cation channel that activates caspase-1 leading to the maturation and secretion of IL-1beta...
  30. pmc Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice
    Janet Chamberlain
    Cardiovascular Research Unit, University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
    Am J Pathol 168:1396-403. 2006
    ..Furthermore, receptor antagonism may be a better therapeutic target than interruption of IL-1beta processing or release...
  31. ncbi P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro
    Stephen D Skaper
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, Essex, United Kingdom
    Glia 54:234-42. 2006
    ....
  32. doi Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes
    Nicola Hamilton
    Department of Physiology, University College London, London, United Kingdom
    Glia 56:734-49. 2008
    ....
  33. doi Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts
    Souzan Armstrong
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Cell Sci 122:136-44. 2009
    ..Osteoclasts express P2X7 receptors (encoded by P2rx7) - Ca(2+)-permeable channels that are activated by high concentrations of extracellular ATP...
  34. doi Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation
    Mark P Kuehnel
    EMBL, Meyerhofstr 1, 69117 Heidelberg, Germany
    J Cell Sci 122:505-12. 2009
    ..ATP then activated the P2X7 receptor (P2X7R) that was necessary for a peak of plasma-membrane actin assembly within 5 to 10 seconds in P2X7R-..
  35. ncbi Cloning and functional characterisation of the mouse P2X7 receptor
    I P Chessell
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, UK
    FEBS Lett 439:26-30. 1998
    We have isolated a 1785-bp complementary DNA (cDNA) encoding the murine P2X7 receptor subunit from NTW8 mouse microglial cells. The encoded protein has 80%, and 85% homology to the human and rat P2X7 subunits, respectively...
  36. ncbi Altered cytokine production in mice lacking P2X(7) receptors
    M Solle
    Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
    J Biol Chem 276:125-32. 2001
    ..Together these results demonstrate that P2X(7)R activation can provide a signal that leads to maturation and release of IL-1 beta and initiation of a cytokine cascade...
  37. ncbi Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
    Jeffrey M Labasi
    Department of Antibacterials, Immunology, and Inflammation, Pfizer Global Research and Development, Pfizer Inc, Groton, CT 06340, USA
    J Immunol 168:6436-45. 2002
    ..These data indicate that ATP does act via the P2X(7)R to affect leukocyte function and that the P2X(7)R can serve as an important component of an in vivo inflammatory response...
  38. ncbi Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor
    Sahil Adriouch
    Universite Denis Diderot, Paris, France
    J Immunol 169:4108-12. 2002
    The P2X7 receptor (P2X(7)R) is an ATP-gated channel that mediates apoptosis of cells of the immune system...
  39. ncbi Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
    Hua Zhu Ke
    Pfizer Global Research and Development, Groton Laboratories, Connecticut 06340, USA
    Mol Endocrinol 17:1356-67. 2003
    ..Our purpose was to explore the involvement of the P2X7 receptor in bone development and remodeling by characterizing the phenotype of mice genetically modified to disrupt the ..
  40. ncbi Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors
    Aurore Colomar
    Departement de Physiologie, Centre de Recherches en Sciences Neurologiques, Universite de Montreal, Montreal H3C 3J7, Canada
    J Biol Chem 278:30732-40. 2003
    The P2X7 receptor, mainly expressed by immune cells, is a ionotropic receptor activated by high concentration of extracellular ATP. It is involved in several processes relevant to immunomodulation and inflammation...
  41. ncbi Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro
    Clemens Boucsein
    Max Delbruck Center for Molecular Medicine, Cellular Neuroscience, Robert Rössle Strasse10, D 13092, Berlin, Germany
    Eur J Neurosci 17:2267-76. 2003
    ..All these parameters were reduced in the presence of purinergic ligands, indicating that purinergic receptor activation attenuated indicators of microglial activation...
  42. ncbi P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells
    Fernand Pierre Gendron
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Neurochem 87:344-52. 2003
    ..BzATP, a potent P2X7 receptor agonist, was more effective than ATP, ADP, or 2-MeSATP at enhancing IFN gamma-induced ERK1/2 phosphorylation...
  43. ncbi The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes
    Hervé Le Stunff
    Laboratoire d activation Cellulaire et Transduction des Signaux, Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, UMR 8619 CNRS, Batiment 430, Universite Paris Sud, 91405 Orsay Cedex, France
    J Biol Chem 279:16918-26. 2004
    ..Both responses to ATPe can be induced by a potent P2X7R agonist, benzoylbenzoyl-ATP, whereas P2X7R antagonists, oxidized ATP and pyridoxalphosphate-6-azophenyl-2',4'-..
  44. ncbi Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation
    Heather L Wilson
    Section of Functional Genomics, Division of Genomic Medicine, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Immunol 173:1202-8. 2004
    ..These data support a general role for the P2X(7)R in the release of leaderless cytokines into the extracellular medium, and indicate how icIL-1ra1 may act upon its extracellular target, the IL-1R...
  45. ncbi Reanalysis of P2X7 receptor expression in rodent brain
    Joan A Sim
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    J Neurosci 24:6307-14. 2004
    ..The P2X7 receptor has been termed the cytolytic non-neuronal P2X receptor because it had not been detected in neurons until ..
  46. ncbi Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages
    Robson Coutinho-Silva
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Biochem Pharmacol 69:641-55. 2005
    ..These techniques also demonstrated the presence of mRNA for P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors along with protein expression for the three subtypes we investigated, namely, P2Y(1), P2Y(2) and P2Y(4)...
  47. ncbi Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
    Iain P Chessell
    Pain Research, N and GI CEDD, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Pain 114:386-96. 2005
    ..Drugs which block this target may have the potential to deliver broad-spectrum analgesia...
  48. ncbi Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia
    Fabio Bianco
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Cellular and Molecular Pharmacology and Department of Medical Pharmacology, University of Milan, Italy
    J Immunol 174:7268-77. 2005
    ..Our data identify astrocyte-derived ATP as the endogenous factor responsible for microvesicle shedding in microglia and reveal the mechanisms by which astrocyte-derived ATP triggers IL-1beta release from these cells...
  49. ncbi A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death
    Rodolphe Auger
    Institut de Biochimie et Biophysique Moleculaire et Cellulaire, Universite Paris Sud, 91405 Orsay Cedex, France
    J Biol Chem 280:28142-51. 2005
    Extracellular ATP (ATPe) binds to P2X7 receptors (P2X7R) expressed on the surface of cells of hematopoietic lineage, including murine thymocytes...
  50. ncbi ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria
    S Lepine
    Biomembranes et Messagers Cellulaires, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8619, Université Paris XI Orsay, France
    Biochim Biophys Acta 1761:73-82. 2006
    ..In conclusion, de novo ceramide generation and mitochondrial alterations, both resulting from P2 X 7R activation, were implicated in ATP-induced thymocyte apoptosis...
  51. pmc Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
    Anke Witting
    Department of Pharmacology, Anesthesiology, Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:6362-7. 2006
    ....
  52. ncbi A role for P2X7 in microglial proliferation
    Fabio Bianco
    CNR Institute of Neuroscience, Milan, Italy
    J Neurochem 99:745-58. 2006
    ..Overall, our data show that the P2X(7) receptor plays an important role in controlling microglial proliferation by supporting cell cycle progression...
  53. ncbi Murine macrophage P2X7 receptors support rapid prothrombotic responses
    Samantha F Moore
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
    Cell Signal 19:855-66. 2007
    ..These data demonstrate that the pro-inflammatory P2X(7) receptor can also support and propagate rapid increases in thrombin formation...
  54. pmc P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes
    Fred Aswad
    Department of Molecular Microbiology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Immunol 243:58-65. 2006
    ..Experiments show that spontaneous T cell proliferation is somewhat higher in cells expressing P2X(7)Rs, but this effect we suggest is caused by P2X(7)R expression on accessory cells...
  55. ncbi P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus
    Lilla Papp
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, Hungary
    Biochem Biophys Res Commun 355:568-74. 2007
    This study was designed to explore the effect of P2X7 receptor (P2X7R) activation on the expression of p38 MAP kinase (p38 MAPK) enzyme in hippocampal slices of wild-type (WT) and P2X7R(-/-) mice using the Western blot technique and to ..
  56. ncbi Regulatory T cells are resistant to apoptosis via TCR but not P2X7
    Simon R J Taylor
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, U K
    J Immunol 178:3474-82. 2007
    ....
  57. pmc Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation
    Zachary A Pfeiffer
    Department of Biomolecular Chemistry and Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, Madison, WI 53706, USA
    Free Radic Biol Med 42:1506-16. 2007
    ....
  58. ncbi Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
    Yan Qu
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 179:1913-25. 2007
    ..export of caspase-1-processed IL-1 beta from monocytes/macrophages in response to activation of P2X7 receptors (P2X7R) by extracellular ATP...
  59. ncbi Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation
    Ramin Raouf
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Neuropharmacology 53:496-504. 2007
    ....
  60. pmc In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain
    Rozenn Mingam
    PsyNuGen, INRA, UMR1286, CNRS, UMR5226, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, France
    Brain Behav Immun 22:234-44. 2008
    ..This is not the case for TNFalpha and IL-6. Our results indicate a selective effect of the P2X7R gene deletion on release of IL-1 beta release but not of IL-6 and TNFalpha...
  61. ncbi Synaptic terminals from mice midbrain exhibit functional P2X7 receptor
    P Marin-Garcia
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense de Madrid, Av Puerta de Hierro s n, 28040 Madrid, Spain
    Neuroscience 151:361-73. 2008
    ..These biochemical and pharmacological experiments are consistent with the presence of a functional P2X(7) receptor in wild type mice midbrain, and the existence of a less efficient "P2X(7)-like" receptor in the KO model...
  62. doi ATP-gated P2X cation-channels
    Michael F Jarvis
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Neuropharmacology 56:208-15. 2009
    ..In this article we have tried to present as much information as possible in two tables in the hope this will be useful as a day-to-day resource, and also because an excellent and detailed review has recently been published...
  63. pmc P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis
    Anthony J Sharp
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 5:33. 2008
    ..These properties suggest a role in the development of autoimmune disease including multiple sclerosis...
  64. doi Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders
    Ana M Basso
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Behav Brain Res 198:83-90. 2009
    ..These data support the relevance of pro-inflammatory cytokines in depressive-like states, and suggest that P2X(7) receptor antagonists could be of potential interest for the treatment of affective disorders...
  65. pmc Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy
    J Biol Chem 284:10120-8. 2009
    ..e. those observed in response to basal ATP release, has an anti-apoptotic or even growth promoting rather than cytotoxic activity...
  66. pmc P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1
    Yan Qu
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 182:5052-62. 2009
    We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 inflammasomes is accompanied by release of MHC class II (MHC-II) protein into extracellular compartments during brief stimulation of murine macrophages with ..
  67. pmc P2X7 deficiency attenuates renal injury in experimental glomerulonephritis
    Simon R J Taylor
    MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
    J Am Soc Nephrol 20:1275-81. 2009
    The P2X7 receptor is a ligand-gated cation channel that is normally expressed by a variety of immune cells, including macrophages and lymphocytes...
  68. pmc Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells
    Shiyuan Hong
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 183:578-92. 2009
    ....
  69. pmc A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice
    Annette Nicke
    Department of Neurochemistry, Max Planck Institute MPI for Brain Research, Deutschordenstrasse 46, Frankfurt 60528, Germany
    J Biol Chem 284:25813-22. 2009
    The ATP-activated P2X7 receptor channel is involved in immune function and inflammatory pain and represents an important drug target...
  70. pmc Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice
    Virginie F Labrousse
    Psychoneuroimmunologie, Nutrition et Génétique PsyNuGen, INRA UMR 1286, CNRS UMR 5226, Universite de Bordeaux, Bordeaux, France
    PLoS ONE 4:e6006. 2009
    ..Taken together, our results show that P2X(7)R plays a critical role in spatial memory processes and the associated hippocampal IL-1beta mRNA synthesis and c-Fos activation...
  71. doi Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells
    Rosa Gomez-Villafuertes
    Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain
    FEBS J 276:5307-25. 2009
    ..Previously, we have reported that P2X7 receptor inhibition promotes axonal growth and branching in cultured hippocampal neurons...
  72. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
    ..These findings suggest that the inhibition of Nlrp3 inflammasome activity can diminish the acute inflammation and damage associated with tissue injury...
  73. doi A potential role for P2X7R in allergic airway inflammation in mice and humans
    Tobias Müller
    Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
    Am J Respir Cell Mol Biol 44:456-64. 2011
    ..Our data suggest that targeting P2X₇R on hematopoietic cells (e.g., DCs or eosinophils) might be a new therapeutic option for the treatment of asthma...
  74. doi P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
    ..Our results suggest P2X(7)R activation may play a novel and direct role in tissue damage through release of cathepsins independently of its proinflammatory actions via IL-1 cytokines...
  75. doi Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes
    Shuangyi Ren
    Department of Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Peoples Republic of China
    Cell Biol Int 34:1205-11. 2010
    ..These results indicate that inhibition of the expression and function of P2X₇R attenuates the metastatic ability of murine lymphoid neoplasm cell line P388D1, which represents a new potential target for anti-metastatic therapy...
  76. doi Intravascular danger signals guide neutrophils to sites of sterile inflammation
    Braedon McDonald
    Immunology Research Group, University of Calgary, Alberta T2N 4N1, Canada
    Science 330:362-6. 2010
    ..Thus, dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation...
  77. pmc Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity
    Felix C Weber
    Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Exp Med 207:2609-19. 2010
    ..The lack of P2X(7) triggering prevents IL-1β release, which is an essential step in the sensitization process. Interference with P2X(7) signaling may be a promising strategy for the prevention of allergic contact dermatitis...
  78. doi Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
    Konrad Wilhelm
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Nat Med 16:1434-8. 2010
    ..These data have major implications for transplantation medicine, as pharmacological interference with danger signals that act via P2X(7)R could lead to the development of tolerance without the need for intensive immunosuppression...
  79. pmc Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner
    Amarjit Mishra
    Lundberg Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Cell Sci 124:657-68. 2011
    ..These results suggest that the activation of P2X(7)R increases surfactant secretion by releasing ATP from AEC I and subsequently stimulating P2Y(2) receptors in AEC II...
  80. pmc P2X7 receptors trigger ATP exocytosis and modify secretory vesicle dynamics in neuroblastoma cells
    Yolanda Gutierrez-Martin
    Departamento de Toxicologia y Farmacologia, Universidad Complutense de Madrid, Madrid, Spain
    J Biol Chem 286:11370-81. 2011
    ..In the present study we used this cell line to investigate a parallel though faster P2X7 receptor-mediated signaling pathway, namely Ca(2+)-regulated exocytosis...
  81. doi Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells
    Míriam León-Otegui
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    FEBS Lett 585:2255-62. 2011
    ..We have demonstrated that activation of the P2X7 receptor leads to a reduction of α-secretase activity in Neuro-2a cells...
  82. pmc P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice
    Christian Furlan-Freguia
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 121:2932-44. 2011
    ..in mouse myeloid cells, ATP-triggered signaling through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (decryption) of TF procoagulant activity and promoted release of TF+ MPs ..
  83. pmc Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts
    Marianela Masin
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Br J Pharmacol 165:978-93. 2012
    Splice variants of P2X7 receptor transcripts contribute to the diversity of receptor-mediated responses...
  84. pmc P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke
    Suffwan Eltom
    Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 6:e24097. 2011
    ..Mice were exposed to CS twice a day to induce COPD-like inflammation and the role of the P2X7 receptor was investigated...
  85. doi Lipopolysaccharide-induced lung injury: role of P2X7 receptor
    Leonardo C Monção-Ribeiro
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Respir Physiol Neurobiol 179:314-25. 2011
    ..P2X7 receptors have been involved in inflammatory and immunological responses, and their activation modulates pro-inflammatory cytokines production by LPS-challenged macrophages...
  86. pmc Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death
    Shoji Notomi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Pathol 179:2798-809. 2011
    Stressed cells release ATP, which participates in neurodegenerative processes through the specific ligation of P2RX7 purinergic receptors...
  87. doi Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice
    Tobias Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    FASEB J 26:1616-28. 2012
    ..green fluorescent protein, we identify dentate granule neurons as the major cell population transcribing the P2X7 receptor after SE. Pretreatment of mice with an intracerebroventricular microinjection of 1...
  88. pmc The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice
    Cecilia Csölle
    Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Int J Neuropsychopharmacol 16:213-33. 2013
    The purpose of this study was to explore how genetic deletion and pharmacological antagonism of the P2X7 receptor (P2rx7) alter mood-related behaviour, gene expression and stress reactivity in the brain...
  89. pmc Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse
    Kirstan A Vessey
    Department of Anatomy and Cell Biology, The University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 7:e29990. 2012
    The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases...
  90. pmc Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
    Brian D Gulbransen
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:600-4. 2012
    ..Inhibition of P2X7R, Panx1, Asc or caspase activity prevented inflammation-induced neuron cell death...
  91. doi P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release
    Maria Barberà-Cremades
    Inflammation and Experimental Surgery Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University Hospital Virgen de Arrixaca Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain
    FASEB J 26:2951-62. 2012
    ..Barberà-Cremades, M., Baroja-Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrín, P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release.
  92. doi Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral γδ cells
    Michela Frascoli
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Immunol 189:174-80. 2012
    ..The impairment of the ERK-Egr-inhibitor of differentiation 3 (Id3) signaling pathway in γδ cells from p2rx7(-/-) mice resulted in increased representation of the Id3-independent NK1...
  93. pmc Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?
    Mia M Thi
    Department of Orthopedic Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Membr Biol 245:401-9. 2012
    ..These data indicate that Panx1 channels, in concert with P2X₇R, likely form a molecular complex that performs the hemichannel function in osteoblast mechanosignaling...
  94. doi P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis
    Gabriela L da Silva
    Programa de Pós Graduação em Biologia Celular e Molecular, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
    Exp Dermatol 22:184-8. 2013
    Irritant contact dermatitis (ICD) is an inflammatory reaction caused by chemical toxicity on the skin. The P2X7 receptor (P2X7R) is a key mediator of cytokine release, which recruits immune cells to sites of inflammation...
  95. doi The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation
    Anna Solini
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    J Pathol 231:342-53. 2013
    ....
  96. ncbi High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors
    Fred Aswad
    Department of Molecular Microbiology and Immunology University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033 0800, USA
    J Immunol 175:3075-83. 2005
    ..Consistent with this, P2X7R gene-deleted mice possess increased levels of forkhead/winged helix transcription factor gene-expressing CD4+CD25+ ..
  97. doi NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells
    Felix Scheuplein
    Institute of Immunology, University Hospital, Hamburg, Germany
    J Immunol 182:2898-908. 2009
    ..The "spontaneous" activation of P2X(7) during preparation of primary T cells could be prevented by i.v. injection of either the surrogate ART substrate etheno-NAD or ART2.2-inhibitory single domain Abs 10 min before sacrificing mice...
  98. ncbi The P2X(7) receptor from Xenopus laevis: formation of a large pore in Xenopus oocytes
    Martin Paukert
    Department of Otolaryngology, Research Group of Sensory Physiology, Röntgenweg 11, D 72076, Tubingen, Germany
    FEBS Lett 513:253-8. 2002
    ..Identification of a non-mammalian P2X(7) receptor may help to identify functionally important parts of the protein...
  99. ncbi Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands
    M Garcia-Marcos
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad del Pais Vasco, Barrio Sarriena S N Leioa, Spain
    FEBS Lett 579:5407-13. 2005
    ..It is concluded that the activation of P2X(7) receptors depolarizes the mitochondrial membrane. The uptake of extracellular sodium is necessary but not sufficient to induce this response...
  100. doi The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells
    Takato Takenouchi
    Transgenic Animal Research Center, National Institute of Agrobiological Sciences, Tsukuba, Japan
    J Immunol 182:2051-62. 2009
    ..Given the critical role of the purinergic P2X7 receptor (P2X7R) pathway during various immunologic functions (i.e...
  101. doi Activation of microglia by amyloid {beta} requires P2X7 receptor expression
    Juana M Sanz
    Department of Clinical and Experimental Medicine, University of Ferrara, Italy
    J Immunol 182:4378-85. 2009
    ..Identification of the P2X(7) receptor as a non-dispensable factor of Abeta-mediated microglia stimulation may open new avenues for the treatment of Alzheimer disease...

Research Grants3

  1. PROTEIN KINASES AND ENDOTHELIAL CELL ACTIVATION
    Josef Anrather; Fiscal Year: 2001
    ..By addressing these specific aims, the principal investigator hopes to provide new insights concerning the regulation of the transcriptional activity of NF-kB in EC and its contribution to inflammation. ..
  2. Role of NF-kappaB phosphorylation in inflammatory signaling
    Josef Anrather; Fiscal Year: 2008
    ..In summary, these studies will establish the role of p65 phosphorylation in achieving signal specificity and provide new insights into the mechanism of NF-KappaB dependent pro-inflammatory gene regulation. ..
  3. Sleep Regulation - The Involvement of GHRH
    James Krueger; Fiscal Year: 2009
    ..Anticipated results are expected to support the hypothesis that GHRH is a key regulatory component of NREMS and provide cellular mechanistic explanations for the involvement of GHRH in sleep regulation. ..