Oxtr

Summary

Gene Symbol: Oxtr
Description: oxytocin receptor
Alias: OTR, oxytocin receptor, OT-R
Species: mouse

Top Publications

  1. pmc A conditional knockout mouse line of the oxytocin receptor
    Heon Jin Lee
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 4483, USA
    Endocrinology 149:3256-63. 2008
  2. doi Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice
    Masahide Yoshida
    Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai, Miyagi 981 8555, Japan
    J Neurosci 29:2259-71. 2009
  3. pmc Oxytocin is an anabolic bone hormone
    Roberto Tamma
    Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 106:7149-54. 2009
  4. pmc Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes
    Joanne Paquin
    Laboratoire de Neuroendocrinologie Développementale, Département de Chimie et de Biochimie, Universite du Quebec, Montreal, QC, Canada H3C 3P8
    Proc Natl Acad Sci U S A 99:9550-5. 2002
  5. pmc Postweaning, forebrain-specific perturbation of the oxytocin system impairs fear conditioning
    J H Pagani
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892 4483, USA
    Genes Brain Behav 10:710-9. 2011
  6. pmc Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
    Yuki Takayanagi
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Proc Natl Acad Sci U S A 102:16096-101. 2005
  7. pmc Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse
    Elizabeth A D Hammock
    Vanderbilt Kennedy Center and Department of Pediatrics, Vanderbilt University School of Medicine, Vanderbilt University Nashville TN, USA
    Front Behav Neurosci 7:195. 2013
  8. doi Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice
    Tatsuya Hattori
    Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara 252 5201, Japan
    Neurosci Res 90:90-4. 2015
  9. pmc Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice
    Megan E Rich
    Laboratory of Neuroendocrinology and Behavior, Department of Biological Sciences, Kent State University, Kent, Ohio, United States of America School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America
    PLoS ONE 9:e98839. 2014
  10. pmc Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats
    Jacqueline M Ho
    Research and Development Service J M H, V T A, B W T, R W C, B H H, D G B, J E B, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108 Department of Medicine J M H, G J M, M W S, D G B, J E B, Division of Metabolism, Endocrinology, and Nutrition, and Diabetes and Obesity Center of Excellence G J M, M W S, Department of Medicine, University of Washington, Seattle, Washington 98195 Program in Neuroscience M Z, S M A, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164
    Endocrinology 155:2845-57. 2014

Scientific Experts

Detail Information

Publications63

  1. pmc A conditional knockout mouse line of the oxytocin receptor
    Heon Jin Lee
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 4483, USA
    Endocrinology 149:3256-63. 2008
    ..Its receptor (Oxtr) is present in peripheral tissues and brain, so a conditional knockout (KO, -/-) would be useful to allow ..
  2. doi Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice
    Masahide Yoshida
    Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai, Miyagi 981 8555, Japan
    J Neurosci 29:2259-71. 2009
    The oxytocin receptor has been implicated in the regulation of reproductive physiology as well as social and emotional behaviors...
  3. pmc Oxytocin is an anabolic bone hormone
    Roberto Tamma
    Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 106:7149-54. 2009
    ..Deletion of OT or the OT receptor (Oxtr) in male or female mice causes osteoporosis resulting from reduced bone formation...
  4. pmc Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes
    Joanne Paquin
    Laboratoire de Neuroendocrinologie Développementale, Département de Chimie et de Biochimie, Universite du Quebec, Montreal, QC, Canada H3C 3P8
    Proc Natl Acad Sci U S A 99:9550-5. 2002
    We recently discovered the existence of the oxytocin/oxytocin receptor (OT/OTR) system in the heart...
  5. pmc Postweaning, forebrain-specific perturbation of the oxytocin system impairs fear conditioning
    J H Pagani
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892 4483, USA
    Genes Brain Behav 10:710-9. 2011
    ..in three lines of transgenic mice: mice that constitutively lack vasopressin 1a (Avpr1a(-/-)) or Oxt receptors (Oxtr(-/-)) and mice that have Oxt receptor loss restricted to the forebrain that begins postweaning (Oxtr(FB/FB))...
  6. pmc Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
    Yuki Takayanagi
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Proc Natl Acad Sci U S A 102:16096-101. 2005
    The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors...
  7. pmc Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse
    Elizabeth A D Hammock
    Vanderbilt Kennedy Center and Department of Pediatrics, Vanderbilt University School of Medicine, Vanderbilt University Nashville TN, USA
    Front Behav Neurosci 7:195. 2013
    ..social behavior, however, the developing brain areas that could respond to ligand activation of the OXT receptor (OXTR) have yet to be identified in this species...
  8. doi Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice
    Tatsuya Hattori
    Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara 252 5201, Japan
    Neurosci Res 90:90-4. 2015
    ..Subsequently, we examined whether the interstrain recognition was regulated by the oxytocin system using oxytocin receptor (OTR)-null mice...
  9. pmc Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice
    Megan E Rich
    Laboratory of Neuroendocrinology and Behavior, Department of Biological Sciences, Kent State University, Kent, Ohio, United States of America School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America
    PLoS ONE 9:e98839. 2014
    Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care...
  10. pmc Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats
    Jacqueline M Ho
    Research and Development Service J M H, V T A, B W T, R W C, B H H, D G B, J E B, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108 Department of Medicine J M H, G J M, M W S, D G B, J E B, Division of Metabolism, Endocrinology, and Nutrition, and Diabetes and Obesity Center of Excellence G J M, M W S, Department of Medicine, University of Washington, Seattle, Washington 98195 Program in Neuroscience M Z, S M A, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164
    Endocrinology 155:2845-57. 2014
    ..determine whether circulating OT inhibits food intake by acting at hindbrain OTRs, we pretreated rats with an OTR antagonist administered into the fourth ventricle (4V) followed by either central or systemic OT administration...
  11. pmc Peg3 mutational effects on reproduction and placenta-specific gene families
    Joomyeong Kim
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America
    PLoS ONE 8:e83359. 2013
    ....
  12. pmc Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing
    Lars Lennart Oettl
    Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany
    Neuron 90:609-21. 2016
    ....
  13. doi Brain region-specific methylation in the promoter of the murine oxytocin receptor gene is involved in its expression regulation
    Hala Harony-Nicolas
    Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel
    Psychoneuroendocrinology 39:121-31. 2014
    ..The actions of both central and peripheral oxytocin are mediated through the oxytocin receptor (Oxtr), which is encoded by a single gene...
  14. pmc Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
    Gul Dolen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA
    Nature 501:179-84. 2013
    ....
  15. doi Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice
    Yoshiyuki Kasahara
    PhD, Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Endocrinology 154:4305-15. 2013
    Oxytocin (OXT) and OXT receptor (OXTR) have been implicated in the regulation of energy homeostasis, but the detailed mechanism is still unclear...
  16. pmc Fear-enhancing effects of septal oxytocin receptors
    Yomayra F Guzman
    Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA
    Nat Neurosci 16:1185-7. 2013
    ..Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of ..
  17. pmc Translational animal models of autism and neurodevelopmental disorders
    Jacqueline N Crawley
    Robert Chason Chair in Translational Research, M I N D Institute Professor of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Dialogues Clin Neurosci 14:293-305. 2012
    ..The field is now poised to employ the most robust phenotypes in the most replicable mouse models for preclinical screening of novel therapeutics...
  18. pmc Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Psychoneuroendocrinology 38:522-32. 2013
    ..e. facing an unfamiliar conspecific during five 20-min daily encounters, and for oxytocin receptor and brain derived neurotrophic factor (BDNF) levels...
  19. pmc Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons
    Miho Nakajima
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 159:295-305. 2014
    ..the discovery of a population of somatostatin (Sst)-positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs)...
  20. pmc The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2
    Marianna Leonzino
    Institute of Neuroscience, Consiglio Nazionale delle Ricerche, Milan 20129, Italy Department of Biotechnology and Translational Medicine, University of Milan, Milan 20129, Italy
    Cell Rep 15:96-103. 2016
    Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal GABA neurotransmission from excitatory to inhibitory, a developmental process known as the GABA switch...
  21. doi Prenatal minocycline treatment alters synaptic protein expression, and rescues reduced mother call rate in oxytocin receptor-knockout mice
    Shinji Miyazaki
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Biochem Biophys Res Commun 472:319-23. 2016
    ..symptoms by intranasal administration of oxytocin and demonstrated the association of polymorphisms in the oxytocin receptor (Oxtr) gene with ASD patients...
  22. pmc A Distributed Network for Social Cognition Enriched for Oxytocin Receptors
    Mariela Mitre
    Skirball Institute for Biomolecular Medicine, Neuroscience Institute, Department of Otolaryngology, Department of Neuroscience and Physiology
    J Neurosci 36:2517-35. 2016
    ..It is believed that oxytocin receptor signaling in the brain is critical for these behaviors, but it is unknown precisely when and where oxytocin ..
  23. doi Generation of Oxtr cDNA(HA)-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner
    Shizu Hidema
    Department of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan
    J Cell Biochem 117:1099-111. 2016
    The neurohypophysial hormone oxytocin (OXT) and its receptor (OXTR) have critical roles in the regulation of pro-social behaviors, including social recognition, pair bonding, parental behavior, and stress-related responses...
  24. pmc Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3
    Benjamin Jurek
    Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg 93040, Germany
    J Neurosci 35:12248-60. 2015
    ..Together, the results indicate that OT modulates CRTC3 translocation, the binding of CRTC3 to the Crf promoter and, ultimately, transcription of the Crf gene...
  25. pmc Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice
    Ruth I Wood
    Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, United States Electronic address
    Physiol Behav 151:469-77. 2015
    ..social behavior, the present study utilized a genetic strategy to determine whether OXT and AVP receptors (OXTR, AVPR1a) are essential for female mice to demonstrate a conditioned social preference for ethanol...
  26. pmc Oxytocin Mediates Entrainment of Sensory Stimuli to Social Cues of Opposing Valence
    Han Kyoung Choe
    McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 87:152-63. 2015
    ..Through genetic, optogenetic, and pharmacological manipulations, we show that oxytocin receptor signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial ..
  27. pmc Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition
    Lu Gao
    J Clin Invest 125:2808-24. 2015
    ..These findings reveal that fetal lungs produce signals to initiate labor when mature and that SRC-1/-2-dependent production of SP-A and PAF is crucial for this process...
  28. pmc Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors
    Ivana Mesic
    Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Neuropsychopharmacology 40:2337-46. 2015
    ..Here we investigated how Gq-protein-coupled metabotropic glutamate receptor 5 (mGluR5) and oxytocin receptor (Oxtr) affect social affiliation and social memory...
  29. pmc Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only
    J H Pagani
    Section on Neural Gene Regulation, National Institute of Mental Health, National Institutes of Health, DHHS, Bethesda
    Genes Brain Behav 14:167-76. 2015
    ..That the oxytocin receptor is expressed in the serotonergic raphe nuclei suggests a mechanism by which the two neurotransmitters may ..
  30. doi The oxytocin receptor impairs ethanol reward in mice
    Amine Bahi
    Department of Anatomy, Tawam Medical Campus, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates Electronic address
    Physiol Behav 139:321-7. 2015
    It is well established that oxytocin, and its receptor (OxtR), play a crucial role in addiction and that the stimulation of oxytocin neurotransmission reduces addictive behaviors to ethanol in laboratory animals...
  31. doi Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan Department of Electrophysiology and Oncology, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    FEBS Lett 588:4404-12. 2014
    ..Retrograde tracer study revealed the projection of PVN and SON Oxt neurons to ARC. These results demonstrate the novel oxytocinergic signaling from PVN/SON to ARC POMC, possibly regulating feeding. ..
  32. pmc Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice
    Martha G Welch
    Department of Psychiatry, Pediatrics, and Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York
    Am J Physiol Gastrointest Liver Physiol 307:G848-62. 2014
    ..Although OT (with secretin) opposes intestinal inflammation, physiological roles played by enteric OT/OTR signaling have not previously been determined...
  33. doi Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect
    M Sala
    Dipartimento di Biotecnologie mediche e Medicina traslazionale, Universita degli Studi di Milano, Milan, Italy
    J Neuroendocrinol 25:107-18. 2013
    We characterised the behavioural phenotype of mice heterozygous (Oxtr(+/-)) for the oxytocin receptor gene (Oxtr) and compared it with that of Oxtr null mice (Oxtr(-/-)), which display autistic-like behaviours, including impaired ..
  34. doi Developmental experiences and the oxytocin receptor system
    Karen L Bales
    Dept of Psychology, One Shields Ave, University of California, Davis, CA 95616, USA
    Horm Behav 61:313-9. 2012
    ..We consider the processes by which experience can affect oxytocin receptor binding, and what is known about the directionality of experience effects on oxytocin receptors...
  35. pmc Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton
    Graziana Colaianni
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York 10029, USA
    J Biol Chem 287:29159-67. 2012
    ..We show that the absence of OT receptors (OTRs) in OTR(-/-) osteoblasts or attenuation of OTR expression in silenced cells inhibits estrogen-induced osteoblast ..
  36. doi Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor
    Monica B Dhakar
    Laboratory of Neuroendocrinology and Behavior, Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
    Horm Behav 62:86-92. 2012
    ..However, there are reports of heightened aggression in Oxt knockout and Oxt receptor (Oxtr) knockout male mice when they are born to null mutant mothers; suggesting that intrauterine exposure to Oxt may be ..
  37. pmc Variation in maternal and anxiety-like behavior associated with discrete patterns of oxytocin and vasopressin 1a receptor density in the lateral septum
    J P Curley
    Columbia University, Department of Psychology, 1190 Amsterdam Avenue, Room 406 Schermerhorn Hall, New York, NY 10025, USA
    Horm Behav 61:454-61. 2012
    ..In addition, we quantified oxytocin (OTR) and vasopressin (V1a) receptor density within the lateral septum to determine the possible correlation with ..
  38. doi N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model
    Eugene Y Chang
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Medical University of South Carolina, Charleston, SC 29492, USA
    J Matern Fetal Neonatal Med 25:2395-400. 2012
    ..We hypothesized that N-acetylcysteine would decrease NF-κB activation and CAP expression in a MIA model for preterm birth...
  39. pmc Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
    Roger L H Pobbe
    Pacific Biosciences Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, USA
    Horm Behav 61:436-44. 2012
    ..we investigated the expression of autism-related behaviors in mice that lack the ability to synthesize the oxytocin receptor itself, Oxtr knockout (KO) mice, as compared to their wild-type (WT) littermates...
  40. doi Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice
    G Murakami
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, Box 275, New York, NY 10065, USA
    Eur J Neurosci 34:469-77. 2011
    ..Social interaction was positively correlated with: oxytocin receptor (OTR) and vasopressin receptor (V1aR) mRNA expression in the medial amygdala; and OT and AVP mRNA expression ..
  41. ncbi Structure and expression of the mouse oxytocin receptor gene
    Y Kubota
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Mol Cell Endocrinol 124:25-32. 1996
    To determine the structure of the mouse oxytocin receptor (OTR) gene, we have screened a mouse genomic library and confirmed cDNA sequence with rapid amplification of cDNA ends...
  42. pmc Opposing actions of prostaglandins and oxytocin determine the onset of murine labor
    G A Gross
    Department of Obstetrics and Gynecology, Washington University School of Medicine, One Children s Place, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:11875-9. 1998
    ..These findings demonstrate that COX-1 is essential for normal labor in the mouse, with a critical function being to overcome the luteotrophic action of oxytocin in late gestation...
  43. ncbi Metanephric rat-mouse chimeras to study cell lineage of the nephron
    L J Arend
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Dev Genet 24:230-40. 1999
    ..evaluated the expression of four relatively well-localized molecules--renin, Tamm-Horsfall protein (THP), oxytocin receptor (OTR), and the vasopressin type 2 receptor (V2R)--in cultured mouse-rat chimeric metanephric kidneys using ..
  44. ncbi Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor
    Victoria J Wesley
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U K
    Biochemistry 41:5086-92. 2002
    The effects of the peptide hormone oxytocin (OT) are mediated by the oxytocin receptor, which is a member of the G-protein-coupled receptor family...
  45. ncbi Characterization of oxytocin receptors and serotonin transporters in mast cells
    Edgardo Vega
    Department of Pharmacology, Facultad de Ciencias Biologicas, Universidad de Concepcion, Chile
    Endocrine 18:167-72. 2002
    ..In this study, OTR and SERT were characterized in murine peritoneal mast cells by radioligand-binding studies...
  46. ncbi Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive
    Tom R Hollon
    Molecular Neuropharmacology Section and Basic Neurosciences Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Neurosci 22:10801-10. 2002
    ....
  47. ncbi Inhibition of oxytocin receptor and estrogen receptor-alpha expression, but not relaxin receptors (LGR7), in the myometrium of late pregnant relaxin gene knockout mice
    Andrew L Siebel
    Department of Zoology, University of Melbourne, Parkville, Victoria 3010, Australia
    Endocrinology 144:4272-5. 2003
    This study used relaxin (RLX) gene knockout mice (Rlx-/-) to investigate the effects of RLX on myometrial oxytocin receptor (OTR) and estrogen receptor (ER)-alpha gene expression in late gestation...
  48. ncbi Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse
    B R Gould
    Laboratory of Molecular Endocrinology, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Neuroscience 122:155-67. 2003
    ..hormone but can also act as a neurotransmitter and as a neuromodulator by interacting with its central OT receptor (OTR)...
  49. ncbi The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle
    Masaki Kawamata
    Department of Molecular Biology, Graduate School of Agriculture, Tohoku University, Sendai 981 8555, Japan
    Biochem Biophys Res Commun 321:695-9. 2004
    ..However, the level of OT receptor (OTR) transcripts and proteins was equivalent at the two phases...
  50. ncbi Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) mice
    Andrew L Siebel
    Department of Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Ann N Y Acad Sci 1041:104-9. 2005
    ..This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium...
  51. ncbi Oxytocin receptor is differentially expressed in mouse endometrium and embryo during blastocyst implantation
    Panagiotis Beretsos
    First Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Athens University Medical School, 50 Achaias St, 115 23, Athens, Greece
    Ann N Y Acad Sci 1092:466-79. 2006
    The oxytocin (OT)-oxytocin receptor (OTR) system of the mammalian uterus has mainly been studied in relation to its involvement in the onset of labor...
  52. doi Oxytocin receptor-deficient mice developed late-onset obesity
    Yuki Takayanagi
    Department of Physiology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Neuroreport 19:951-5. 2008
    The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption...
  53. doi Behavioural studies using temporal and spatial inactivation of the oxytocin receptor
    Heon Jin Lee
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, DHHS, Bethesda, MD, USA
    Prog Brain Res 170:73-7. 2008
    ..In both the periphery and CNS, Oxt actions are transduced by the oxytocin receptor (Oxtr)...
  54. doi New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance
    Katsuhiko Nishimori
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan
    Prog Brain Res 170:79-90. 2008
    To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-)...
  55. doi Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice
    Hong Xiang Liu
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurosci Lett 448:67-70. 2008
    ..These results showed that the reduced severity of behavioral abnormalities in CD38(-/-) pups was due to partial compensation by the high level of plasma OT...
  56. pmc Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition
    A H Macbeth
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892 4483, USA
    Genes Brain Behav 8:558-67. 2009
    We studied three lines of oxytocin (Oxt) and oxytocin receptor (Oxtr) knockout (KO) male mice [Oxt(-/-), total Oxtr(-/-) and partial forebrain Oxtr (Oxtr(FB/FB))] with established deficits in social recognition to further refine our ..
  57. doi Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL
    Konstantinos Stefanidis
    Laboratory of Stem Cells, Division of Reproductive Medicine, Alexandra Maternity Hospital, 1st Department of Obstetrics and Gynecology, Medical School, N and K University of Athens, 15 Neapoleos str, Marousi, Greece
    Biosystems 98:122-6. 2009
    ..RNA was isolated from EBs and using RT-PCR we showed that EBs expressed Oct-4, OTR, OT, and DAZL...
  58. pmc Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse
    Ara Schorscher-Petcu
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Neurosci 30:8274-84. 2010
    ..Here, we characterized the phenotype of oxytocin receptor (OTR) and vasopressin-1A receptor (V1AR) null mutant mice in a battery of pain assays...
  59. pmc Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Respir Res 11:104. 2010
    ..that oxytocin regulates inflammatory processes in other tissues given the ubiquitous expression of the oxytocin receptor. The purpose of this study was to define the role of oxytocin in modulating human airway smooth muscle (..
  60. pmc Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptide
    Bogdan A Danalache
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    PLoS ONE 5:e13643. 2010
    ..we investigated whether OT-GKR exists in fetal and newborn rodent hearts, interacts with the OT receptors (OTR) and primes the generation of contracting cells expressing CM markers in P19 cells, a model for the study of early ..
  61. pmc β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration
    Chad A Grotegut
    Div of Maternal Fetal Medicine, Dept of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27710, USA
    Am J Physiol Endocrinol Metab 300:E468-77. 2011
    Desensitization of the oxytocin receptor (OXTR) in the setting of prolonged oxytocin exposure may lead to dysfunctional labor, which increases the risk for cesarean delivery, and uterine atony, which may result in postpartum hemorrhage...
  62. doi Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Endocrinology 152:2619-25. 2011
    ..Because MGN3-1 cells express only oxytocin receptor mRNA, not vasopressin receptor mRNA, oxytocin is the likely regulator, with the effect of vasopressin ..
  63. ncbi Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene
    S Kaluz
    University of Nottingham, Loughborough, UK
    Gene 172:313-4. 1996
    The oxytocin receptor (OTR), a member of the seven-transmembrane domain guanine-nucleotide-binding protein (G protein) coupled receptor family plays a central role in lactation, ovarian cyclicity and reproductive behaviour...