Otud7b

Summary

Gene Symbol: Otud7b
Description: OTU domain containing 7B
Alias: 2900060B22Rik, 4930463P07Rik, AI462125, CEZANNE, Trabid2, Za20d1, OTU domain-containing protein 7B, TRAF binding domain containing 2, cellular zinc finger anti-NF-kappa-B protein, zinc finger A20 domain-containing protein 1, zinc finger protein Cezanne, zinc finger, A20 domain containing 1
Species: mouse

Top Publications

  1. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
  2. doi Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
    Le A Luong
    Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK
    Circ Res 112:1583-91. 2013
  3. ncbi A novel type of deubiquitinating enzyme
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:23180-6. 2003
  4. pmc Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
    Anja Bremm
    Buchmann Institute for Molecular Life Sciences, Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO Rep 15:1268-77. 2014
  5. pmc Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
    Hongbo Hu
    Department of Rheumatology and Immunology, State Key Laboratory of Biotherapy and Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030
    J Exp Med 213:399-414. 2016
  6. pmc Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
    Hoanh Tran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    Genes Dev 22:528-42. 2008
  7. pmc DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
    R Sean McNally
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 286:4098-106. 2011

Scientific Experts

  • Anja Bremm
  • Paul C Evans
  • Hongbo Hu
  • Jin Jin
  • Yichuan Xiao
  • Jae Hoon Chang
  • Xuhong Cheng
  • Shao Cong Sun
  • Le A Luong
  • R Sean McNally
  • Hoanh Tran
  • Xiaoping Xie
  • Qiang Zou
  • Hui Wang
  • Yang Xin Fu
  • Charles Pusey
  • Sarah Harten
  • George C Brittain
  • Sarah R Walmsley
  • Maria Fragiadaki
  • Anna Zal
  • Dorian O Haskard
  • Jens Lutz
  • Patrick H Maxwell
  • Mikyoung Chang
  • Jonathan L E Dean
  • Margaret Ashcroft
  • Joseph Boyle
  • Jennifer Smith
  • Chengming Zhu
  • Nahum Puebla-Osorio
  • Tomasz Zal
  • Henning Walczak
  • Mary Ann Accavitti-Loper
  • Beckley K Davis
  • Jenny P Y Ting
  • Tak W Mak
  • Casey M Clements
  • Thomas Schwarz-Romond
  • Fumihiko Hamada
  • Mariann Bienz

Detail Information

Publications7

  1. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
    ..Here we have identified the deubiquitinase OTUD7B as a pivotal regulator of the non-canonical NF-κB pathway...
  2. doi Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
    Le A Luong
    Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK
    Circ Res 112:1583-91. 2013
    ..Thus, cellular mechanisms that suppress tumor necrosis factor receptor-associated factor 6 ubiquitination are potential therapeutic targets to reduce inflammation in hypoxic tissues...
  3. ncbi A novel type of deubiquitinating enzyme
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:23180-6. 2003
    ..J. (2001) Biochem. J. 357, 617-623). One of these molecules, cellular zinc finger anti-NF-kappaB (Cezanne), a 100-kDa cytoplasmic protein, also suppressed NF-kappaB...
  4. pmc Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
    Anja Bremm
    Buchmann Institute for Molecular Life Sciences, Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO Rep 15:1268-77. 2014
    ..Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1α homeostasis...
  5. pmc Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
    Hongbo Hu
    Department of Rheumatology and Immunology, State Key Laboratory of Biotherapy and Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030
    J Exp Med 213:399-414. 2016
    ..In this study, we demonstrate a ubiquitin-dependent mechanism in which the deubiquitinase Otud7b has a crucial role in facilitating TCR signaling...
  6. pmc Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
    Hoanh Tran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    Genes Dev 22:528-42. 2008
    ..Our results indicate a role of K63-linked ubiquitin chains during Wnt-induced transcription...
  7. pmc DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
    R Sean McNally
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 286:4098-106. 2011
    ..Mass spectrometry shows that DJ-1 interacts with BBS1, CLCF1, MTREF, and Cezanne/OTUD7B/Za20d1. Among these, Cezanne is a known deubiquitination enzyme that inhibits NF-κB activity...