Oprm1

Summary

Gene Symbol: Oprm1
Description: opioid receptor, mu 1
Alias: M-OR-1, MOP-R, MOR-1, MOR-1O, Oprm, mor, muOR, mu-type opioid receptor, MOP receptor, mu opioid receptor MOR-1BI, mu opioid receptor MOR-1P, mu opioid receptor splice variant mMOR-1Z
Species: mouse

Top Publications

  1. pmc Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 22:4085-95. 2008
  2. doi Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strains
    Yoshihiro Shigeta
    Division of Psychobiology, Tokyo Institute of Psychiatry, Japan
    Pharmacogenet Genomics 18:927-36. 2008
  3. pmc Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
    Y Joy Yu
    Program in Neuroscience, University of California at San Francisco, San Francisco, California 94158 2140, USA
    J Neurosci 29:222-33. 2009
  4. pmc NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor
    María Rodríguez-Muñoz
    CIBER Mental Health CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain
    Antioxid Redox Signal 14:2413-25. 2011
  5. ncbi Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions
    Miao Tan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    J Neurosci 23:10292-301. 2003
  6. ncbi STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors
    Christine Börner
    Department of Pharmacology and Toxicology, University of Magdeburg, Magdeburg, Germany
    J Neurochem 91:1493-500. 2004
  7. ncbi Formalin-induced pain is reduced in sigma(1) receptor knockout mice
    Cruz Miguel Cendan
    Department of Pharmacology and Institute of Neurosciences, School of Medicine, University of Granada, Avenida de Madrid 12, 18012 Granada, Spain
    Eur J Pharmacol 511:73-4. 2005
  8. ncbi Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor
    G C Rossi
    George C Cotzias Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    FEBS Lett 369:192-6. 1995
  9. ncbi Chromosomal localization of opioid peptide and receptor genes in the mouse
    B Giros
    INSERM U 288, Neurobiologie Cellulaire et Fonctionnelle, CHU Pitie Salpetriere, Paris, France
    Life Sci 56:PL369-75. 1995
  10. ncbi Characterization of the murine mu opioid receptor gene
    D L Kaufman
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90024, USA
    J Biol Chem 270:15877-83. 1995

Research Grants

  1. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
  2. Role of Amygdala in Ethanol Reinforcement and Anxiety
    Amanda Roberts; Fiscal Year: 2005
  3. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
  4. OPIOID GABA INTERACTIONS AND ANTINOCICEPTION
    Alexander Kalyuzhny; Fiscal Year: 2002
  5. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
  6. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006

Detail Information

Publications126 found, 100 shown here

  1. pmc Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 22:4085-95. 2008
    ..We propose a mechanism in which miRNA23b blocks the association of MOR1 mRNA with polysomes, thereby arresting its translation and suppressing the production of MOR1 protein...
  2. doi Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strains
    Yoshihiro Shigeta
    Division of Psychobiology, Tokyo Institute of Psychiatry, Japan
    Pharmacogenet Genomics 18:927-36. 2008
    ..Inbred mouse strains that are genetically different and isogenic within each strain are useful for elucidating the genetic mechanisms underlying the interindividual differences in opioid-induced analgesia...
  3. pmc Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
    Y Joy Yu
    Program in Neuroscience, University of California at San Francisco, San Francisco, California 94158 2140, USA
    J Neurosci 29:222-33. 2009
    ..We found that ligand-induced activation of NK1Rs produces a cell-autonomous and nonreciprocal inhibition of MOR endocytosis induced by diverse opioids...
  4. pmc NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor
    María Rodríguez-Muñoz
    CIBER Mental Health CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain
    Antioxid Redox Signal 14:2413-25. 2011
    In the brain, the mu-opioid receptor (MOR) activates neural nitric oxide synthase (nNOS) through the PI3K/Akt pathway...
  5. ncbi Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions
    Miao Tan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    J Neurosci 23:10292-301. 2003
    ..Our data suggest that the PI3Kcascade involving MAPK and Akt enhances micro-opioid desensitization via postreceptor modifications that interfere with G-protein-effector interactions...
  6. ncbi STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors
    Christine Börner
    Department of Pharmacology and Toxicology, University of Magdeburg, Magdeburg, Germany
    J Neurochem 91:1493-500. 2004
    ..In contrast, the non-canonical STAT6 site of the delta-opioid receptor binds STAT6 with similar high activity as a perfectly palindromic STAT6 site and is strongly inducible by IL-4...
  7. ncbi Formalin-induced pain is reduced in sigma(1) receptor knockout mice
    Cruz Miguel Cendan
    Department of Pharmacology and Institute of Neurosciences, School of Medicine, University of Granada, Avenida de Madrid 12, 18012 Granada, Spain
    Eur J Pharmacol 511:73-4. 2005
    ..These results suggest that the tonic pain induced by formalin is altered in mice lacking sigma1 receptors, and highlight the potential usefulness of further studies of the role of sigma1 receptors in models of non-acute pain...
  8. ncbi Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor
    G C Rossi
    George C Cotzias Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    FEBS Lett 369:192-6. 1995
    Although MOR-1 encodes a mu opioid receptor, its relationship to the pharmacologically defined mu receptor subtypes has been unclear. Antisense mapping now suggests that these subtypes result from alternative splicing of MOR-1...
  9. ncbi Chromosomal localization of opioid peptide and receptor genes in the mouse
    B Giros
    INSERM U 288, Neurobiologie Cellulaire et Fonctionnelle, CHU Pitie Salpetriere, Paris, France
    Life Sci 56:PL369-75. 1995
    ..In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (..
  10. ncbi Characterization of the murine mu opioid receptor gene
    D L Kaufman
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90024, USA
    J Biol Chem 270:15877-83. 1995
    ....
  11. pmc Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene
    B H Min
    Department of Pharmacology, University of Minnesota, Minneapolis 55455
    Proc Natl Acad Sci U S A 91:9081-5. 1994
    We have isolated mouse mu opioid receptor genomic clones (termed MOR) containing the entire amino acid coding sequence corresponding to rat MOR-1 cDNA, including additional 5' flanking sequence...
  12. ncbi Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors
    K Raynor
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104
    Mol Pharmacol 45:330-4. 1994
    ..The availability of the cloned receptors will facilitate the identification and development of more specific and selective compounds with greater therapeutic potential and fewer undesirable side effects...
  13. ncbi Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene
    H W Matthes
    UPR 9050 CNRS, ESBS Université Louis Pasteur, Strasbourg, France
    Nature 383:819-23. 1996
    ..We conclude that the mu-opioid-receptor gene product is the molecular target of morphine in vivo and that it is a mandatory component of the opioid system for morphine action...
  14. pmc Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia
    I Sora
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 94:1544-9. 1997
    ..These results implicate endogenous opioid-peptide actions at mu opiate receptors in several tests of nociceptive responsiveness and support mu receptor mediation of morphine-induced analgesia in tests of spinal and supraspinal analgesia...
  15. ncbi Dual promoters of mouse mu-opioid receptor gene
    J L Ko
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    Biochem Biophys Res Commun 234:351-7. 1997
    ..We found that receptor mRNA was predominantly initiated by the proximal promoter. These studies suggested that the proximal promoter was the major functional promoter...
  16. ncbi mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit
    S Roy
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Brain Res Mol Brain Res 56:281-3. 1998
    The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO)...
  17. ncbi Methadone analgesia in morphine-insensitive CXBK mice
    A Chang
    The Cotzias Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur J Pharmacol 351:189-91. 1998
    ..These results reveal distinct analgesic mechanisms for morphine and methadone and provide further support for multiple subtypes of mu-opioid receptors...
  18. ncbi MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions
    S Roy
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Brain Res Mol Brain Res 61:190-4. 1998
    The role of the mu-opioid receptor in immune function was investigated using mu-opioid receptor knockout mice (MOR-KO)...
  19. ncbi Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms
    Y X Pan
    The Cotzias Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Pharmacol 56:396-403. 1999
    We have identified four new mu-opiod receptor (MOR)-1 exons, indicating that the gene now contains at least nine exons spanning more than 200 kilobases. Replacement of exon 4 by combinations of the new exons yields three new receptors...
  20. ncbi Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F
    Y X Pan
    The Cotzas Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    FEBS Lett 466:337-40. 2000
    The MOR-1 gene is large, with a recent study reporting nine exons spanning 250 kb which combine to yield six different mu opioid receptor splice variants...
  21. ncbi Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
    D Filliol
    1 UPR 9050 CNRS, ESBS Université Louis Pasteur, Illkirch, Strasbourg, France
    Nat Genet 25:195-200. 2000
    ..The mu-, delta- and kappa- opioid receptors (encoded by Oprm, Oprd1 and Oprk1, respectively) mediate the biological activity of opioids...
  22. ncbi Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    Sandy Ghozland
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:1146-54. 2002
    ..Thus, an opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC...
  23. ncbi Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Biol Chem 278:3742-50. 2003
    ..factors that bind to specific sequences in 5'-distal promoter regulatory sequences of the mouse mu opioid receptor (mor) promoter using the yeast one-hybrid system...
  24. ncbi Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors
    Stephanie L Borgland
    Department of Pharmacology, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:18776-84. 2003
    ....
  25. ncbi Increased dopamine D2 receptor binding and enhanced apomorphine-induced locomotor activity in mu-opioid receptor knockout mice
    Lu Tai Tien
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Brain Res Bull 61:109-15. 2003
    ..The enhanced locomotor activity may be related to the compensatory up-regulation of D2 dopamine receptors in mice lacking mu-opioid receptor genes...
  26. ncbi The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells
    Wei Wang
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455 0217, USA
    J Biol Chem 278:36848-58. 2003
    The mu- and delta-opioid receptors (MOR and DOR) differ significantly in their intracellular trafficking...
  27. ncbi Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice
    Vladimir I Chefer
    Integrative Neuroscience Section, DHHS NIH NIDA IRP BNRB INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:1915-22. 2003
    ..rate of DA uptake, in the nucleus accumbens (NAc) of wild-type mice and those with a constitutive deletion of mu (MOR)- or delta (DOR)-opioid receptors. Locomotor activity was assessed in these same animals...
  28. ncbi Transcriptional regulation of mouse mu opioid receptor gene by PU.1
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Biol Chem 279:19764-74. 2004
    We previously reported that the 34-bp cis-acting element of the mouse micro opioid receptor (MOR) gene represses transcription of the MOR gene from the distal promoter...
  29. ncbi Deficit in attachment behavior in mice lacking the mu-opioid receptor gene
    Anna Moles
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Psychobiology and Psychopharmacology, Viale Marx 43, 00137 Roma, Italy
    Science 304:1983-6. 2004
    ..Results from this study may indicate a molecular mechanism for diseases characterized by deficits in attachment behavior, such as autism or reactive attachment disorder...
  30. ncbi Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization
    Javier Garzón
    Department of Neuropharmacology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, E 28002 Madrid, Spain
    J Biol Chem 280:8951-60. 2005
    In mouse periaqueductal gray matter (PAG) membranes, the mu-opioid receptor (MOR) coprecipitated the alpha-subunits of the Gi/o/z/q/11 proteins, the Gbeta1/2 subunits, and the regulator of G-protein signaling RGS9-2 and its partner ..
  31. ncbi Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
    Ping Yee Law
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455 0217, USA lawxx001 umn edu
    J Biol Chem 280:11152-64. 2005
    ..by producing the phenotypes of the 1:1 heterodimers formed between the constitutively expressed mu-opioid receptor (MOR) and the ponasterone A-induced expression of delta-opioid receptor (DOR) in EcR293 cells...
  32. pmc Mu-opioid receptors modulate the stability of dendritic spines
    Dezhi Liao
    Department of Neuroscience and Basic Research Center on Molecular and Cell Biology of Drug Addiction, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 102:1725-30. 2005
    ..By activating ubiquitously clustered mu-opioid receptor (MOR) in excitatory synapses, morphine caused collapse of preexisting dendritic spines and decreased synaptic alpha-..
  33. ncbi Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice
    Sandy Ghozland
    Department of Neuropharmacology SP 315, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:493-501. 2005
    ..Mice lacking the mu-opioid receptor (MOR) do not self-administer ethanol and display decreased anxiety-like behavior...
  34. ncbi Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous system
    Yahong Zhang
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain Res 1099:33-43. 2006
    The mu opioid receptor gene Oprm is alternatively spliced into many variants, providing for the multiplicity of mu opioid receptor subtypes...
  35. pmc Translational repression of mouse mu opioid receptor expression via leaky scanning
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nucleic Acids Res 35:1501-13. 2007
    Mu opioid receptor (MOR) expression is under temporal and spatial controls, but expression levels of the MOR gene are relatively low in vivo...
  36. pmc Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 395:98-107. 2007
    The mouse mu-opioid receptor gene, Oprm1, currently contains 18 recognized alternatively spliced exons [Doyle, G.A., Sheng, X.R., Lin, S.S.J., Press, D.M., Grice, D.E., Buono, R.J., Ferraro, T.N., Berrettini, W.H., 2007...
  37. pmc Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4720-36. 2007
    The pharmacological effect of morphine as a painkiller is mediated mainly via the mu opioid receptor (MOR) and is dependent on the number of MORs in the cell surface membrane...
  38. ncbi Decreased motivation to eat in mu-opioid receptor-deficient mice
    Francesco Papaleo
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Eur J Neurosci 25:3398-405. 2007
    ..To assess the role for the micro-opioid receptor (MOR) pathway in the motivational properties of food intake, in the present study we tested wild-type and MOR-deficient ..
  39. pmc Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Mol Med 12:2319-33. 2008
    ..actions of morphine and morphine-like drugs such as heroin mediate primarily through the mu opioid receptor (MOR). It represents the target of the most valuable painkiller in contemporary medicine...
  40. pmc Differential activation and trafficking of micro-opioid receptors in brain slices
    Seksiri Arttamangkul
    Vollum Institute, L474, Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 W Sam Jackson Park Dr, Portland, OR 97239, USA
    Mol Pharmacol 74:972-9. 2008
    ..Brain slices from these mice were used to study tagged MOR receptors in neurons of the locus ceruleus...
  41. doi NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors
    María Rodríguez-Muñoz
    Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Madrid, Spain
    Cell Signal 20:1855-64. 2008
    In neurons, the C terminus of the Mu-opioid receptor (MOR) binds to the protein kinase C-interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) which in turn binds the regulator of G-protein signalling RGSZ1/Z2 (..
  42. pmc HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis
    Jonathan Moorman
    Departments of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochim Biophys Acta 1793:1366-71. 2009
    ..These data suggest a novel mechanism by which HIV-1 gp120 and opioids induce lymphocyte cell death...
  43. pmc Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    J Cell Mol Med 13:3591-615. 2009
    The pharmacological action of morphine as a pain medication is mediated primarily through the mu-opioid receptor (MOR). With few exceptions, MOR is expressed in brain regions where opioid actions take place...
  44. pmc Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms
    V I Chefer
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Eur J Neurosci 30:272-8. 2009
    Mu opioid receptor (MOR) regulation of somatodendritic dopamine neurotransmission in the ventral tegmental area (VTA) was investigated using conventional microdialysis in freely moving rats and mice...
  45. pmc Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor
    Li He
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
    FASEB J 23:4327-34. 2009
    Growing evidence shows that trafficking of the mu-opioid receptor (MOR) is a critical process in functional recovery from desensitization following activation and plays important roles in morphine tolerance and dependence largely because ..
  46. pmc Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 78:58-68. 2010
    The effects of morphine are mediated mainly through the mu opioid receptor (MOR)...
  47. pmc Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons
    Hai bo Wang
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Proc Natl Acad Sci U S A 107:13117-22. 2010
    ..Importantly, both DOR and MOR agonists reduce depolarization-induced Ca(2+) currents in single small DRG neurons and inhibit afferent C-fiber ..
  48. pmc Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent
    Jessica M Breslow
    Center for Substance Abuse Research, Department of Microbiology, Temple University School of Medicine, 3400 N Broad St, Philadelphia, PA 19140, USA
    Microb Pathog 49:330-5. 2010
    ..These results provide definitive evidence that the morphine-mediated enhancement of oral Salmonella infection is dependent on the μ-opioid receptor...
  49. pmc Ultrastructural relationship between the mu opioid receptor and its interacting protein, GPR177, in striatal neurons
    Arith Ruth S Reyes
    Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res 1358:71-80. 2010
    ..the mammalian ortholog of Drosophila Wntless/Evi/Sprinter, was recently identified as a novel mu-opioid receptor (MOR) interacting protein...
  50. pmc Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation
    Chad E Groer
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA
    J Biol Chem 286:31731-41. 2011
    Morphine and other opiates mediate their effects through activation of the μ-opioid receptor (MOR), and regulation of the MOR has been shown to critically affect receptor responsiveness...
  51. pmc Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
    Xian Yu Liu
    Center for the Study of Itch, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA
    Cell 147:447-58. 2011
    ..We now report that the μ-opioid receptor (MOR) isoform MOR1D is essential for morphine-induced scratching (MIS), whereas the isoform MOR1 is required only for ..
  52. pmc Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:19778-83. 2011
    ..that this agent acts through a truncated, six-transmembrane variant of the G protein-coupled mu opioid receptor MOR-1...
  53. pmc Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
    Aashish Manglik
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 485:321-6. 2012
    ..These high-resolution insights into opioid receptor structure will enable the application of structure-based approaches to develop better drugs for the management of pain and addiction...
  54. ncbi mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality
    H H Loh
    Dept of Pharmacology, University of Minnesota Medical School, 3 249 Millard Hall, 435 Delaware St S E, Minneapolis, MN 55455, USA
    Brain Res Mol Brain Res 54:321-6. 1998
    The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure...
  55. ncbi Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice
    S J Slowe
    Pharmacology Research Group, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
    Brain Res 818:335-45. 1999
    ..This effect was most notable in the nucleus accumbens and the vertical limb of the diagonal band, and suggests there may be functional interactions between mu- and delta-receptors and kappa1- and delta-receptors in mouse brain...
  56. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
    Previously, we reported that the neuron-restrictive silencer element (NRSE) of mu opioid receptor (MOR) functions as a critical regulator to repress the MOR transcription in specific neuronal cells, depending on neuron-restriction ..
  57. pmc Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence
    Joseph A Kim
    Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, California 94608, USA
    Curr Biol 18:129-35. 2008
    ..These data suggest that opioid drugs with a pharmacological profile similar to morphine but the ability to promote endocytosis could provide analgesia while having a reduced liability for promoting tolerance and dependence...
  58. pmc Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors
    Michael Tanowitz
    Department of Psychiatry, University of California, San Francisco, California 94158 2140, USA
    J Biol Chem 283:35614-21. 2008
    ..To our knowledge the present results are the first to establish a role of alternative RNA processing in specifying the post-endocytic sorting of G-protein-coupled receptors between divergent and functionally distinct membrane pathways...
  59. pmc Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
    ..Like morphine, heroin has high affinity and selectivity for mu-receptors, but its residual analgesia in exon 1 MOR-1 knockout mice that do not respond to morphine suggests a different mechanism of action...
  60. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
    ..Using a DOReGFP reporter mouse we now show that the DOR and MOR are, in fact, expressed by different subsets of primary afferents...
  61. ncbi Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
    The mu opioid receptor (MOR) is expressed in the central nervous system and specific cell lines with varying expression levels perhaps playing important roles...
  62. ncbi A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 68:279-85. 2005
    The pharmacological effects of opioid drugs are mediated mainly by the mu-opioid receptor (MOR), which is encoded by an mRNA transcript named MOR1...
  63. ncbi Mu opioid receptors are expressed on radial glia but not migrating neuroblasts in the late embryonic mouse brain
    Tim J Sargeant
    School of Biological Science, Victoria University of Wellington, New Zealand
    Brain Res 1175:28-38. 2007
    ..Surprisingly, the distribution of the mu opioid receptor (MOR) in the embryonic brain, especially in proliferative regions, is poorly defined and subject to conflicting reports...
  64. ncbi Murine chromosomal location of the mu and kappa opioid receptor genes
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 21:659-61. 1994
    ..Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1...
  65. ncbi Identification of an octamer-1 transcription factor binding site in the promoter of the mouse mu-opioid receptor gene
    Y Liang
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    J Neurochem 67:1352-9. 1996
    In a previous study we showed that a region from -182 to +10 bp in the mouse mu-opioid receptor (MOR) promoter exhibited strong promoter activity...
  66. ncbi Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1
    A G Schuller
    Dept of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway 08854, USA
    Nat Neurosci 2:151-6. 1999
    Morphine produces analgesia by activating mu opioid receptors encoded by the MOR-1 gene...
  67. ncbi mu-Opioid receptor knockout mice do not self-administer alcohol
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 293:1002-8. 2000
    ..These data provide new evidence for a critical role for mu-opioid receptors in ethanol self-administration assessed with a variety of behavioral paradigms and new insights into the neuropharmacological basis for ethanol reinforcement...
  68. pmc Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene
    Y X Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:14084-9. 2001
    Using 5' RACE, we have isolated four additional exons of the mu opioid receptor gene (Oprm), resulting in a gene spanning over 250 kb...
  69. pmc Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice
    M Narita
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Br J Pharmacol 126:451-6. 1999
    ..These thus indicate a limited physiological mu-receptor reserve. Furthermore, little change in delta1-, delta2- or kappa1-opioid receptor-G-protein complex appears to accompany mu-opioid receptor gene deletions in this region...
  70. doi Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice
    Xiaofang Tang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China University of Chinese Academy of Sciences, Beijing, PR China
    Biol Reprod 92:118. 2015
    ..These novel findings add a new line of evidence to better understand the causes for obvious adverse effects of opioid abuse on pregnancy success in women. ..
  71. pmc Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse
    Ronald R Waclaw
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Neurosci 30:6944-53. 2010
    ..Additional support for a dLGE origin of the ITCs was obtained in conditional mutants of the dLGE gene Sp8. Thus, our findings indicate diverse origins for the neuronal components that comprise the amygdalar fear circuit...
  72. doi Potentiation of dopamine D1-like receptor signaling by concomitant activation of δ- and μ-opioid receptors in mouse medial prefrontal cortex
    Maria C Olianas
    Section of Neurosciences, Department of Biomedical Sciences University of Cagliari, Cagliari, Italy
    Neurochem Int 61:1404-16. 2012
    ..This previously unrecognized synergistic interaction may selectively affect DA D1 transmission at specific postsynaptic sites where the receptors are co-localized and may play a role in prefrontal DA D1 regulation of opioid addiction...
  73. pmc MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 27:522-35. 2013
    Opioid receptor (MOR) level is directly related to the function of opioid drugs, such as morphine and fentanyl...
  74. ncbi Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 18:2538-49. 1998
    ..Several examples of possible autocrine and paracrine loops of opioid peptide and receptor expression have been identified, suggesting a role for these local circuits in developmental processes...
  75. ncbi An autoradiographic study in mu-opioid receptor knockout mice
    H Chen
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN, USA
    Brain Res Mol Brain Res 76:170-2. 2000
    ..Our results suggest destroying functional mu-opioid receptor does not affect the expression of the other two opioid receptors...
  76. ncbi ZFOR2, a new opioid receptor-like gene from the teleost zebrafish (Danio rerio)
    A Barrallo
    Department of Biochemistry and Molecular Biology, Department of Medicine, Faculty of Medicine, University of Salamanca, Campus Unamuno, Salamanca 37007, Spain
    Brain Res Mol Brain Res 84:1-6. 2000
    ..Nevertheless, ZFOR2 lacks the fourth exon found in human and rodent mu opioid receptors, that is known to be involved in desensibilization and internalization processes...
  77. ncbi Differential effects of morphine, DPDPE, and U-50488 on apomorphine-induced climbing behavior in mu-opioid receptor knockout mice
    C G Jang
    Department of Pharmacology College of Pharmacy, Sungkyunkwan University, 440 746, Suwon, South Korea
    Brain Res Mol Brain Res 94:197-9. 2001
    ..Therefore, the our results show that dopaminergic activation measured by climbing behavior in mu-opioid receptors knockout mice are differently regulated by mu-, delta-, and kappa-opioid receptor agonists...
  78. ncbi Antisense oligodeoxynucleotides to mu- and delta-opioid receptor mRNA block the enhanced effects of opioids during intestinal inflammation
    O Pol
    Anesthesiology Research Unit, IMIM, Department of Anesthesiology, Hospital Universitario del Mar, Universidad Autonoma de Barcelona, Spain
    Eur J Pharmacol 428:127-36. 2001
    ....
  79. ncbi Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene
    Hirokazu Mizoguchi
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurosci Lett 335:91-4. 2002
    ..receptor agonists in the pons/medulla membrane obtained from mice lacking exons 2 and 3 of mu-opioid receptor gene (MOR (Exons 2 and 3)-knockout (KO) mice) was investigated by monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)..
  80. ncbi Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo 142 8501, Japan
    J Neurosci 23:1006-12. 2003
    ....
  81. pmc Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation
    David Philippe
    Equipe Mixte INSERM 0114 sur la Physiopathologie des Maladies Inflammatoires Intestinales, Centre Hospitalier Universitaire, Lille, France
    J Clin Invest 111:1329-38. 2003
    The physiologic role of the mu opioid receptor (MOR) in gut nociception, motility, and secretion is well established...
  82. ncbi Differential involvement of the mu and kappa opioid receptors in spatial learning
    L Jamot
    The Samuel Lunenfeld Research Institute at Mt Sinai Hospital, and the Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Genes Brain Behav 2:80-92. 2003
    In order to test the role of mu and kappa opioid receptors (Mu opioid receptor (MOR) and Kappa opioid receptor (KOR)) in hippocampal-dependent spatial learning, we analyzed genetically engineered null mutant mice missing the functional ..
  83. pmc Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout mice
    Lu Tai Tien
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4504, USA
    Brain Res Mol Brain Res 126:38-44. 2004
    ..These data indicate that there are up-regulation of acetylcholinesterase activity and compensatory down-regulation of M2 muscarinic receptors in the striatal caudate putamen and nucleus accumbens of mu-opioid receptor knockout mice...
  84. ncbi The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors
    Patricia Robledo
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 20:853-8. 2004
    ..These differences could be due to distinct mechanisms controlling dopamine release in the nucleus accumbens and suggest that the effects of MDMA on dopaminergic neurons are independent of micro -opioid receptors...
  85. ncbi Mu-opioid receptor and CREB activation are required for nicotine reward
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 46:933-43. 2005
    ..of CREB phosphorylation similar to that seen following nicotine administration, and this response is absent in MOR(-/-) mice...
  86. pmc Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis
    Gaetane Mace
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 24:3235-46. 2005
    Morphine analgesic properties and side effects such as tolerance are mediated by the mu opioid receptor (MOR) whose endocytosis is considered of primary importance for opioid pharmacological effects...
  87. ncbi Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
    Antoine Tabarin
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, University of Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Diabetes 54:3510-6. 2005
    ..Using adult male mice lacking the mu-opioid receptor (MOR) gene (MOR-/-), we show that the MOR is not essential for the maintenance of normal levels of ad libitum food ..
  88. ncbi Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms
    Yun Guan
    Department ofAnesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:4298-307. 2006
    The mu-opioid receptor (MOR) plays a critical role in morphine analgesia and nociceptive transmission...
  89. ncbi Knock-in mice reveal nonsense-mediated mRNA decay in the brain
    Candice Contet
    Genesis 45:38-43. 2007
    ..We introduced, by homologous recombination in mouse, a PTC in the mu opioid receptor gene (mor). mor transcript was severely downregulated in the brain of these knock-in mice...
  90. pmc Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis
    Martin O Job
    Division of Pharmacology, College of Pharmacy, University of Texas, 1 University Station, Austin, TX 78712, USA
    Biol Psychiatry 62:627-34. 2007
    ..Mu (mu)-opioid (MOP) receptors modulate accumbal dopamine activity, but it is not clear whether MOP receptors are involved in the mechanism of ethanol-stimulated accumbal dopamine release...
  91. ncbi Mu opioid receptor knockout mice in the Morris Water Maze: a learning or motivation deficit?
    Marianne E Lubbers
    Ethology and Welfare, Department of Animals, Science and Society, Faculty of Veterinary Medicine, Utrecht University and Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Behav Brain Res 180:107-11. 2007
    ..Eur J Neurosci 2004;20(6):1624-32] suggested that mu opioid receptor (MOR) knockout mice have deficits in the motivational component rather than in the information processing component of ..
  92. ncbi Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice
    M Izikki
    1Institut National de la Santé et de la Recherche Médicale U841 and Département de Physiologie, Hôpital H Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Physiol Lung Cell Mol Physiol 293:L1045-52. 2007
    ..These results provide evidence that dysregulation of 5-HT synthesis is closely linked to the hypoxic PH phenotype in mice and that Tph1 and Tph2 may contribute to PH development...
  93. doi Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor
    K Befort
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, France
    Ann N Y Acad Sci 1129:175-84. 2008
    ....
  94. doi Acute in utero morphine exposure slows G2/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse
    Tim J Sargeant
    School of Biological Sciences, Wellington 6140, New Zealand
    Eur J Neurosci 28:1060-7. 2008
    ..These findings indicate that opioid signalling plays a role in cell cycle progression of both radial glia and basal progenitor cells in vivo in the developing cerebral cortex...
  95. pmc Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation
    Priyank Kumar
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Queens, NY 11439, USA
    Eur J Pharmacol 597:39-45. 2008
    ..Taken together, these studies indicate that analgesic efficacy and treatment protocol are important in determining tolerance and regulation of mu-opioid receptors...
  96. pmc Preference for a high fat diet, but not hyperphagia following activation of mu opioid receptors is blocked in AgRP knockout mice
    Maria J Barnes
    Pennington Biomedical Research Center, Nutrition and Neural Signaling Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 1317:100-7. 2010
    Activation of mu opioid receptors (MOR) makes animals hyperphagic and selectively increases their preference for a high fat diet independent of their dietary preference...
  97. doi Lack of social exploratory activation in male μ-opioid receptor KO mice in response to playback of female ultrasonic vocalizations
    Markus Wohr
    Experimental and Physiological Psychology, Philipps University of Marburg, Marburg, Germany
    Soc Neurosci 6:76-87. 2011
    ..Hence, these findings support the phenotypic relevance of Orpm(-/-) mice for the study of autism...
  98. doi The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (μ-opioid receptor) knockout mice
    Babette Kogel
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Zieglerstrasse 6, 52078 Aachen, Germany
    Neurosci Lett 491:104-7. 2011
    ..The novel analgesic tapentadol combines MOR agonism and NRI in a single molecule. The present study used OPRM1 (MOR) knockout (KO) mice to determine the relative contribution of MOR activation to tapentadol-induced analgesia ..
  99. pmc Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids
    Subhas Das
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:29806-17. 2011
    ....
  100. pmc Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice
    M Tian
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Exp Med 185:1517-22. 1997
    ..Taken together, these results suggest a novel role of the mu opioid receptor in hematopoiesis and reproductive physiology, in addition to its known involvement in pain relief...
  101. ncbi The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia
    I Sora
    Molecular Neurobiology Branch, National Institute on Drug Abuse IRP, Baltimore, MD 21224, USA
    Eur J Pharmacol 324:R1-2. 1997
    ..The analgesia induced by this classic delta-opioid receptor agonist depends on intact mu-opioid receptors, suggesting that selective delta-opioid receptor drugs may require mu-opioid receptor occupancies for full efficacy...

Research Grants6

  1. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
    ..abstract_text> ..
  2. Role of Amygdala in Ethanol Reinforcement and Anxiety
    Amanda Roberts; Fiscal Year: 2005
    ..This INIA makes use of several Genetic Animal Models Core Components, relates well to other INIA UOls, and also will provide input to the Gene Expression, Imaging and the Bioinformatics Cores. ..
  3. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  4. OPIOID GABA INTERACTIONS AND ANTINOCICEPTION
    Alexander Kalyuzhny; Fiscal Year: 2002
    ..Results of this study will contribute to our understanding of the mechanisms of opioid anti-nociception, and will suggest strategies for developing alterative, non-opioid, approaches for pain-treatment. ..
  5. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ....
  6. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..