Oprk1

Summary

Gene Symbol: Oprk1
Description: opioid receptor, kappa 1
Alias: K-OR-1, KOR, KOR-1, MSL-1, Oprk2, R21, kappa-type opioid receptor, opioid receptor, kappa 2
Species: mouse

Top Publications

  1. ncbi Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells
    K F Shen
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461
    J Neurosci 14:5570-9. 1994
  2. ncbi Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior
    Mei Bigliardi-Qi
    Department of Dermatology, CHUV Hôpital Beaumont, Lausanne, Switzerland
    J Invest Dermatol 127:1479-88. 2007
  3. ncbi Nociception increases during opioid infusion in opioid receptor triple knock-out mice
    A Juni
    Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, NY 11367, USA
    Neuroscience 147:439-44. 2007
  4. pmc Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 282:29803-11. 2007
  5. ncbi Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
    Elizabeth J Sweger
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:2309-17. 2007
  6. pmc Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase
    Mei Xu
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 27:2570-81. 2007
  7. ncbi Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
    Miquel Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 17:701-8. 2003
  8. pmc Opioid receptors: from binding sites to visible molecules in vivo
    Brigitte L Kieffer
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, F 67400 France INSERM, U596, Illkirch F 67400, France CNRS, UMR7104, Illkirch F 67400, France
    Neuropharmacology 56:205-12. 2009
  9. pmc Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal
    F Simonin
    UPR 9050 CNRS, ESBS Université Louis Pasteur, Strasbourg, France
    EMBO J 17:886-97. 1998
  10. pmc Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 27:11614-23. 2007

Research Grants

  1. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
  2. AFFINITY LABELS FOR OPIOID RECEPTORS
    Jane V Aldrich; Fiscal Year: 2010
  3. MAPPING OF ALCOHOL PREFERENCE GENES IN RQI STRAINS
    Csaba Vadasz; Fiscal Year: 2002
  4. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
  5. Controlling Apoptosis in Oligondendrocytes
    Pamela Knapp; Fiscal Year: 2005
  6. Opioids Modulate Oligodendrocyte Development & Function
    Pamela Knapp; Fiscal Year: 2006
  7. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
  8. OPIOID PEPTIDE ANALOGS AS PROBES OF OPIOID RECEPTORS
    JANE ALDRICH; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications95

  1. ncbi Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells
    K F Shen
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461
    J Neurosci 14:5570-9. 1994
    ..These in vitro studies suggest that excitatory opioid receptor-mediated functions may play a role in mediating some types of rapid NGF-induced hyperalgesic and other physiologic effects on the nervous system...
  2. ncbi Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior
    Mei Bigliardi-Qi
    Department of Dermatology, CHUV Hôpital Beaumont, Lausanne, Switzerland
    J Invest Dermatol 127:1479-88. 2007
    The mu- (MOR) and kappa- (KOR) opioid receptors have been implicated in the regulation of homeostasis of non-neuronal cells, such as keratinocytes, and sensations like pain and chronic pruritus...
  3. ncbi Nociception increases during opioid infusion in opioid receptor triple knock-out mice
    A Juni
    Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, NY 11367, USA
    Neuroscience 147:439-44. 2007
    ....
  4. pmc Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 282:29803-11. 2007
    ..and atrans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl) piperidine (JDTic) are selective kappa opioid receptor (KOR) antagonists having very long durations of action in vivo despite binding non-covalently in vitro and having only ..
  5. ncbi Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
    Elizabeth J Sweger
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:2309-17. 2007
    ..This study discovered a new model of hydrocephalus in which the rate of pathogenesis can be controlled enabling the study of the pathogenesis of both juvenile and adult onset hydrocephalus...
  6. pmc Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase
    Mei Xu
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 27:2570-81. 2007
    ..in the L4-L5 spinal dorsal horn of wild-type, but not in dynorphin knock-out, mice lacking kappa opioid receptors (KOR-/-) or in wild-type mice pretreated with the KOR antagonist nor-binaltorphimine (norBNI)...
  7. ncbi Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
    Miquel Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 17:701-8. 2003
    We have examined responses of mice lacking mu, delta and kappa opioid receptor (MOR, DOR and KOR, respectively) genes, as well as combinatorial mutants, in several pain models...
  8. pmc Opioid receptors: from binding sites to visible molecules in vivo
    Brigitte L Kieffer
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, F 67400 France INSERM, U596, Illkirch F 67400, France CNRS, UMR7104, Illkirch F 67400, France
    Neuropharmacology 56:205-12. 2009
    ..Importantly, we will identify a number of research directions that are likely to develop during the next decade...
  9. pmc Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal
    F Simonin
    UPR 9050 CNRS, ESBS Université Louis Pasteur, Strasbourg, France
    EMBO J 17:886-97. 1998
    ..To investigate the contribution of the kappa-opioid receptor (KOR) to opioid function in vivo, we have generated KOR-deficient mice by gene targeting...
  10. pmc Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 27:11614-23. 2007
    ..Here, we show that repeated swim stress caused activation of both kappa-opioid receptor (KOR) and p38 mitogen-activated protein kinase (MAPK) coexpressed in GABAergic neurons in the nucleus accumbens, cortex, ..
  11. pmc Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination
    Feng Mei
    Department of Neurology, University of California, San Francisco, California 94158, Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, 400038, China, and
    J Neurosci 36:7925-35. 2016
    ..G-protein-coupled receptor small-molecule library, we report the identification of a cluster of κ-opioid receptor (KOR) agonists that significantly promotes oligodendrocyte differentiation and myelination...
  12. pmc Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors
    Eunhae Kim
    E A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 281:33749-60. 2006
    ..We detected mu-opioid receptor (MOR-1) and kappa-opioid receptor (KOR-1) expression and immunoreactivity in embryonic stem (ES) cells and in retinoic acid-induced ES cell-derived, ..
  13. ncbi Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice
    Michael A Ansonoff
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School UMDNJ RWJMS, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Pharmacol Exp Ther 318:641-8. 2006
    ..divinorum, selective for kappa(1)-opioid receptors, and that salvinorin A and specific structurally related analogs produce behavioral effects that require the kappa-opioid receptor...
  14. ncbi Formalin-induced pain is reduced in sigma(1) receptor knockout mice
    Cruz Miguel Cendan
    Department of Pharmacology and Institute of Neurosciences, School of Medicine, University of Granada, Avenida de Madrid 12, 18012 Granada, Spain
    Eur J Pharmacol 511:73-4. 2005
    ..These results suggest that the tonic pain induced by formalin is altered in mice lacking sigma1 receptors, and highlight the potential usefulness of further studies of the role of sigma1 receptors in models of non-acute pain...
  15. ncbi No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse
    Candice Contet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Parc d innovation, 1 rue Laurent Fries BP 10142, C U de Strasbourg, 67404 Illkirch Cedex, France
    Eur J Pharmacol 492:131-6. 2004
    ..We conclude that the brain epsilon site involves mu, delta and/or kappa receptors, possibly coupled to nonclassical G proteins...
  16. pmc Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action
    Jane V Aldrich
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
    Proc Natl Acad Sci U S A 106:18396-401. 2009
    ..2005) J Med Chem 48: 4500-4503} is a selective peptide kappa opioid receptor (KOR) antagonist that shows activity following systemic administration. Systemic (1-3 mg/kg s.c.) as well as central (0...
  17. ncbi Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    Sandy Ghozland
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:1146-54. 2002
    ..Thus, an opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC...
  18. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
  19. pmc Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism
    Julia C Lemos
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 32:12325-36. 2012
    ..for the dysphoric effects of dynorphin-κ-opioid receptor system activation during stress-evoked behaviors, and KOR-induced activation of p38α mitogen-activated protein kinase (MAPK) in serotonergic neurons was found to be a ..
  20. pmc μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice
    Yvonne Schmidt
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Freie Universitat Berlin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 8:e79099. 2013
    ..Furthermore, our findings suggest a rigorous tissue-dependent characterization of antibodies' specificity, preferably using knockout animals. ..
  21. doi Preimplantation mouse embryo is a target for opioid ligand-receptor signaling
    Yongjie Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People s Republic of China University of Chinese Academy of Sciences, Beijing, People s Republic of China
    Biol Reprod 91:4. 2014
    ....
  22. pmc Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence
    Pierre Eric Lutz
    1 Translational Medicine and Neurogenetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U 964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France 2 McGill Group for Suicide Studies, Douglas Institute Research Centre, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 39:2694-705. 2014
    ..We show that delta and kappa opioid receptor (DOR and KOR, respectively) knockout mice develop either stronger or reduced emotional disruption during heroin abstinence, ..
  23. pmc Kappa opioid receptors on dopaminergic neurons are necessary for kappa-mediated place aversion
    Vladimir I Chefer
    Integrative Neuroscience Section, Integrative Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD, USA
    Neuropsychopharmacology 38:2623-31. 2013
    Kappa-opioid receptor (KOR) agonists have dysphoric properties in humans and are aversive in rodents. This has been attributed to the activation of KORs within the mesolimbic dopamine (DA) system...
  24. pmc Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity
    Ashlee Van't Veer
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 38:1585-97. 2013
    ..To further evaluate how KOR function affects behavior, we developed mutant mice in which exon 3 of the KOR gene (Oprk1) was flanked with Cre-lox recombination (loxP) sites...
  25. doi κ-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice
    H Fukagawa
    Department of Anesthesia, Kyoto University Hospital, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Br J Anaesth 113:1032-8. 2014
    ..However, it is not known whether genetic deletion of KOP affects the N2O actions...
  26. doi Activation of κ-opioid receptor exerts the glucose-homeostatic effect in streptozotocin-induced diabetic mice
    Yulong Shang
    Department of Physiology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    J Cell Biochem 116:252-9. 2015
    ..This effect is associated with the translocation of Glut4 and might be relevant to increased adiponectin, AdipoR1, and AMPK phosphorylation...
  27. doi Dynorphin activation of kappa opioid receptor reduces neuronal excitability in the paraventricular nucleus of mouse thalamus
    Zhiheng Chen
    Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, China
    Neuropharmacology 97:259-69. 2015
    It has been reported that kappa opioid receptor (KOR) is expressed in the paraventricular nucleus of thalamus (PVT), a brain region associated with arousal, drug reward and stress...
  28. doi An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist
    Michael K Pugsley
    Department of Global Safety Pharmacology and Toxicology, Janssen Pharmaceuticals LLC, Raritan, NJ 08869, United States Electronic address
    Eur J Pharmacol 761:330-40. 2015
    ..Transient outward and sustained outward K(+) currents were blocked by PD117,302. Thus, the ECG changes and antiarrhythmic effects observed in vivo result from direct blockade of multiple cardiac ion channels. ..
  29. pmc Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons
    Jonathan M Ehrich
    Graduate Program in Neurobiology and Behavior, Department of Pharmacology, and
    J Neurosci 35:12917-31. 2015
    The endogenous dynorphin-κ opioid receptor (KOR) system encodes the dysphoric component of the stress response and controls the risk of depression-like and addiction behaviors; however, the molecular and neural circuit mechanisms are ..
  30. doi Centrally administered apelin-13 induces depression-like behavior in mice
    Shuang Yu Lv
    Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu 730000, China
    Brain Res Bull 88:574-80. 2012
    ..These results indicate that centrally administered apelin-13 elicited depression-like behavior in mice, which was mediated via APJ receptor and κ-opioid receptor, but not CRF receptor...
  31. pmc Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway
    Thiago M Cunha
    Department of Pharmacology, School of Medicine of Ribeirao Preto University of Sao Paulo, Av, Bandeirantes, 3900, 14049 900, Ribeirao Preto SP, Brazil
    Mol Pain 8:10. 2012
    ..activation are able to direct block PGE(2)-induced ongoing hyperalgesia However, this effect was not tested for KOR selective activation...
  32. doi Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection
    Eduard Schunk
    Department of Pharmacology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Hippocampus 21:1010-20. 2011
    ....
  33. pmc The role of endogenous dynorphin in ethanol-induced state-dependent CPP
    Khanh Nguyen
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, United States
    Behav Brain Res 227:58-63. 2012
    ..However, these mice compared to their respective controls exhibited a greater CPP response following an ethanol (1g/kg) challenge, suggesting that the endogenous DYN/KOP system may negatively regulate ethanol-induced state-dependent CPP...
  34. pmc Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference
    Jeffrey S Smith
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 32:1488-95. 2012
    ..Together, these data implicate the amygdala as a key region modulating the appetitive properties of nicotine, and suggest that κ-opioid antagonists may be useful therapeutic tools to reduce stress-induced nicotine craving...
  35. pmc Morphological and behavioral changes in the pathogenesis of a novel mouse model of communicating hydrocephalus
    Allison B McMullen
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e30159. 2012
    ....
  36. doi IFN-γ up-regulates κ opioid receptors (KOR) on murine macrophage cell line J774
    Jelka Gabrilovac
    Division of Molecular Medicine Laboratory for Experimental Haematology, Immunology and Oncology, Ruđer Bošković Institute, Zagreb, Croatia
    J Neuroimmunol 245:56-65. 2012
    In this study we examined basal and IFN-γ-regulated expression of kappa opioid receptors (KOR) on cells of a murine macrophage cell line, J774. Basal KOR expression was found both at transcriptional and protein levels...
  37. ncbi Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice
    Herve Boutin
    CNRS UMR 6185, Centre Cyceron, Caen, France
    Acta Neuropathol 114:491-500. 2007
    ..Changes in opioidergic receptor expression in these regions may be involved in the long-term consequences of stroke and could be used as biomarker of neuronal alteration through the use of imaging techniques in the clinic...
  38. ncbi Identification of kappa- and delta-opioid receptor transcripts in immune cells
    C Gaveriaux
    Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France
    FEBS Lett 369:272-6. 1995
    ..In conclusion, our results lead to the identification of kappa and delta opioid receptor transcripts in immune cells...
  39. ncbi Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor
    Timothy A Vortherms
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 282:3146-56. 2007
    ..of the hallucinogenic sage Salvia divinorum, is an apparently selective and highly potent kappa-opioid receptor (KOR) agonist...
  40. doi Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)
    Patrick R Verhoest
    Neuroscience Medicinal Chemistry, Pfizer PharmaTherapeutics Research and Development, Groton, Connecticut, USA
    J Med Chem 54:5868-77. 2011
    ..This strategy identified 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242, which entered phase 1 clinical testing and has demonstrated target engagement in healthy volunteers...
  41. pmc Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:19919-24. 2006
    kappa-opioid receptor (KOR) is detected pre- and postsynaptically, but the subcellular localization, translation, and regulation of kor mRNA in presynaptic compartments of sensory neurons remain elusive...
  42. doi The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development
    Kohei Yamamizu
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Blood 118:775-85. 2011
    ..Kappa opioid receptor (KOR), an inhibitory G protein-coupled receptor, was highly expressed in embryonic stem cell-derived Flk1(+) vascular ..
  43. pmc Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice
    Megumi Aita
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Mol Pain 6:8. 2010
    The dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury...
  44. ncbi Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction
    G Gerra
    Programma Dipendenze Patologiche, Ser T, AUSL Parma, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:771-5. 2007
    Variants of the opioid receptors are the obvious candidates underlying addiction. The kappa opioid receptor (KOR) system seems to play a role in stress responsivity, opiate withdrawal and responses to psycho-stimulants, inhibiting ..
  45. pmc CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior
    Michael R Bruchas
    Department of Pharmacology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e8528. 2009
    ..Corticotropin Releasing Factor (CRF) were triggered by CRF(1)-R activation of the dynorphin/kappa opioid receptor (KOR) system. Central CRF administration significantly reduced the percent open-arm time in the elevated plus maze (EPM)...
  46. pmc Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse
    Pamela E Knapp
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Neurosci Lett 451:114-8. 2009
    ..Mechanism(s) leading to deficient KOP expression in jimpy mice remain unclear. We speculate that loss of KOP may be related to increased [Ca(2+)](i) and premature death of jimpy oligodendrocytes...
  47. pmc Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:19168-73. 2009
    ..Activation of the dynorphin/kappa opioid receptor (KOR) system by either repeated stress or agonist produces conditioned place aversion (CPA)...
  48. ncbi Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice
    Stanley M Crain
    Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave Bronx, NY 10461, USA
    Brain Res 1167:31-41. 2007
    ..These studies may clarify complex mechanisms underlying opioid physical dependence and opioid addiction...
  49. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
    ..express the Dyn and NKB genes but also the NKB receptor gene (NK3) and the Dyn receptor [the kappa opioid receptor (KOR)] gene...
  50. pmc Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia
    L Gendron
    Department of Pharmacology, Health Sciences Building, University of Washington, Seattle, WA 98195 7280, USA
    Neuroscience 150:807-17. 2007
    ..We therefore conclude that DOR-mediated antihyperalgesia is dependent on MOR expression but that activation of MOR by endogenous opioids is probably not required...
  51. doi p38: the link between the kappa-opioid receptor and dysphoria
    Gregory V Carr
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:2299-300. 2008
  52. pmc Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice
    S Inan
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Neuroscience 163:23-33. 2009
    ..On the basis of our results, nalfurafine holds promise as a potentially useful antipruritic in human conditions involving itch...
  53. doi Involvement of kappa-opioid receptors in visceral nociception in mice
    M H Larsson
    Department of Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
    Neurogastroenterol Motil 20:1157-64. 2008
    ..to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR)...
  54. pmc Telomere length regulation in mice is linked to a novel chromosome locus
    L Zhu
    Rowe Program in Genetics, Departments of Biological Chemistry and Medicine University of California, Davis, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 95:8648-53. 1998
    ..This locus is distinct from candidate genes encoding known telomere-binding proteins or telomerase components. These results demonstrate that an unidentified gene(s) mapped to distal chromosome 2 regulates telomere length in the mouse...
  55. ncbi Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene
    S Clarke
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Brain Res 906:13-24. 2001
    ..There were a small number of region specific changes in the expression of classical opioid receptors that may relate to interdependent function with ORL1...
  56. ncbi Scanning of five chromosomes for alcohol consumption loci
    C Vadasz
    Laboratory of Neurobehavior Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962, Orangeburg, NY, USA
    Alcohol 22:25-34. 2000
    ..1) and opioid receptor kappa 3 (chr. 2), respectively. The results of this gene-mapping study suggest that genetic polymorphisms in kappa opioid receptors may contribute to genetic predisposition to voluntary alcohol-drinking behavior...
  57. ncbi Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1)
    T Ito
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gene 244:55-63. 2000
    ..Linkage analysis showed that Tcea1 and Tcea1-ps1 are mapped on mouse chromosomes 1 and 15, respectively. Relationships between Tcea1 and S-II cDNAs isolated so far are discussed...
  58. ncbi Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice
    V J Whatley
    Alcohol Research Center, Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 23:1262-71. 1999
    ..C57BL/6 inbred mice prefer alcohol whereas DBA/2 mice avoid it. We describe the construction of congenic strains of mice in which DBA/2 alleles for alcohol avoidance were placed on a C57BL/6 background using phenotypic selection...
  59. ncbi A nonsense mutation in a novel gene is associated with retinitis pigmentosa in a family linked to the RP1 locus
    X Guillonneau
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Hum Mol Genet 8:1541-6. 1999
    ..Our results suggest that R677X is responsible for disease in this family and that the gene corresponding to hG28 is the RP1 gene...
  60. pmc G-protein-coupled receptor heterodimerization modulates receptor function
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Nature 399:697-700. 1999
    ..Furthermore, the kappa-delta heterodimer synergistically binds highly selective agonists and potentiates signal transduction. Thus, heterodimerization of these GPCRs represents a novel mechanism that modulates their function...
  61. ncbi Promoter activity of mouse kappa opioid receptor gene in transgenic mouse
    X Hu
    Department of Pharmacology, University of Minnesota Medical School, 3 249 Millard Hall, 435 Delaware St SE, Minneapolis, MN 55455, USA
    Brain Res Mol Brain Res 69:35-43. 1999
    The biological activity of mouse kappa opioid receptor (KOR) gene promoter was examined in transgenic mice using a beta-galactosidase (lacZ) reporter strategy for the first time...
  62. ncbi Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice
    S J Slowe
    Pharmacology Research Group, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
    Brain Res 818:335-45. 1999
    Mice deficient in the kappa-opioid receptor (KOR) gene have recently been developed by the technique of homologous recombination and shown to lack behavioural responses to the selective kappa1-receptor agonist U-50,488H...
  63. ncbi Expression of opioid receptors and ligands in pregnant mouse uterus and placenta
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Biol Reprod 59:925-32. 1998
    ..Taken together, these results suggest multiple roles for the opioid receptors and opioid peptides in maternal adaptation to pregnancy and in supporting embryo growth...
  64. ncbi Quantitative trait loci influencing morphine antinociception in four mapping populations
    S E Bergeson
    Waggoner Center for Alcohol and Addiction Research, Institutes of Cellular and Molecular Biology and Neuroscience, University of Texas at Austin, Austin, Texas 78712 1095, USA
    Mamm Genome 12:546-53. 2001
    ..The Chr 1 QTL was evident only in females and comapped with the kappa-opioid receptor gene, Oprk...
  65. ncbi Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 18:2538-49. 1998
    ..Several examples of possible autocrine and paracrine loops of opioid peptide and receptor expression have been identified, suggesting a role for these local circuits in developmental processes...
  66. pmc Cloning and functional comparison of kappa and delta opioid receptors from mouse brain
    K Yasuda
    Howard Hughes Medical Institute, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 90:6736-40. 1993
    ....
  67. ncbi Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors
    K Raynor
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104
    Mol Pharmacol 45:330-4. 1994
    ..The availability of the cloned receptors will facilitate the identification and development of more specific and selective compounds with greater therapeutic potential and fewer undesirable side effects...
  68. pmc Agonists and antagonists bind to different domains of the cloned kappa opioid receptor
    H Kong
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104
    Proc Natl Acad Sci U S A 91:8042-6. 1994
    ..The ability to dissociate agonist- and antagonist-binding sites will facilitate the development of more specific kappa agonists, which could have analgesic properties devoid of side effects...
  69. ncbi Murine chromosomal location of the mu and kappa opioid receptor genes
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 21:659-61. 1994
    ..Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric...
  70. ncbi Chromosomal localization of opioid peptide and receptor genes in the mouse
    B Giros
    INSERM U 288, Neurobiologie Cellulaire et Fonctionnelle, CHU Pitie Salpetriere, Paris, France
    Life Sci 56:PL369-75. 1995
    ..Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms...
  71. ncbi Cloning and promoter mapping of mouse kappa opioid receptor gene
    H C Liu
    Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA
    Biochem Biophys Res Commun 209:639-47. 1995
    We have isolated mouse kappa opioid receptor (KOR) genomic clones containing the complete 5'-untranslated region, a portion of the 3'-untranslated region, and its coding region...
  72. ncbi Sequence of kappa-opioid receptor cDNA in the R1.1 thymoma cell line
    S M Belkowski
    Department of Microbiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Neuroimmunol 62:113-7. 1995
    ..Comparison of these sequences to the previously published kappa-opioid receptor cDNA sequence suggests the presence of an intron-exon junction in the 5' non-coding region...
  73. ncbi Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development
    C Le Moine
    UMR CNRS 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Neuroscience 112:131-9. 2002
    ....
  74. ncbi Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors
    Hiroaki Yamada
    Department of Autonomic Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba ken 260 8670, Japan
    Brain Res 1083:61-9. 2006
    ..Lower potency of U50,488H in mu opioid receptor knockout mice suggests interaction between kappa and mu opioid receptors at the spinal level...
  75. ncbi Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor
    Florence Merg
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    J Neurochem 97:292-301. 2006
    ..A (Dyn A), and dynorphin B (Dyn B) are endogenous opioid peptides that activate the kappa-opioid receptor (KOR)...
  76. pmc Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine
    Vladimir I Chefer
    Integrative Neuroscience Section, Behavioral Neurosciences Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 25:5029-37. 2005
    Genetic and pharmacological approaches were used to examine kappa-opioid receptor (KOR-1) regulation of dopamine (DA) dynamics in the nucleus accumbens and vulnerability to cocaine...
  77. ncbi Retinoic acid-induced chromatin remodeling of mouse kappa opioid receptor gene
    Sung Wook Park
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci 25:3350-7. 2005
    The mouse kappa opioid receptor (KOR) gene is constitutively expressed in P19 embryonic stem cells but is first suppressed and reactivated during retinoic acid (RA)-induced neuronal differentiation...
  78. ncbi Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy
    Masayuki Hiramatsu
    Laboratory of Neuropsychopharmacology, Graduate School of Environmental and Human Sciences, Meijo University, Tenpaku ku, Nagoya 468 8503, Japan
    Brain Res 1030:247-55. 2004
    ....
  79. ncbi The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice
    Gregory Scherrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR7104, Parc d Innovation, 1 rue Laurent Fries BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Eur J Neurosci 19:2239-48. 2004
    ....
  80. ncbi Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration
    J A Garcia-Sevilla
    Laboratori de Neurofarmacologia, Unitat Associada de l Instituto de Neurobiología Ramón y Cajal CSIC, Facultat de Ciencies, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
    Neuropharmacology 46:519-30. 2004
    ..The induction of heterologous receptor adaptations in mu-KO mice may explain this paradoxical effect of morphine...
  81. ncbi Mouse kappa-opioid receptor mRNA differential transport in neurons
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St, SE, Minneapolis, MN 55455, USA
    Mol Pharmacol 64:594-9. 2003
    Three kappa-opioid receptor (KOR) mRNA isoforms have been detected in different parts of the central nervous system...
  82. ncbi Differential involvement of the mu and kappa opioid receptors in spatial learning
    L Jamot
    The Samuel Lunenfeld Research Institute at Mt Sinai Hospital, and the Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Genes Brain Behav 2:80-92. 2003
    In order to test the role of mu and kappa opioid receptors (Mu opioid receptor (MOR) and Kappa opioid receptor (KOR)) in hippocampal-dependent spatial learning, we analyzed genetically engineered null mutant mice missing the functional ..
  83. ncbi Enhanced humoral response in kappa-opioid receptor knockout mice
    Claire Gaveriaux-Ruff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP10142, 67404 Illkirch Cedex, C U de Strasbourg, France
    J Neuroimmunol 134:72-81. 2003
    ..Here, we investigated the contribution of kappa-opioid receptor (KOR) activity in immunity in vivo by studying immune responses in KOR knockout mice...
  84. ncbi Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice
    Sian Clarke
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, GU2 7XH UK
    Eur J Neurosci 16:1705-12. 2002
    ..Labelling of the ORL1 receptor with [3H]nociceptin showed region-dependent quantitative increases in triple knockout brains indicating a close relationship between the two systems in specific brain areas...
  85. ncbi Regulation of mouse kappa opioid receptor gene expression by different 3'-untranslated regions and the effect of retinoic acid
    Xinli Hu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA
    Mol Pharmacol 62:881-7. 2002
    The mouse kappa opioid receptor (KOR) gene uses two functional polyadenylation signals, separated by a distance of approximately 2.2 kilobases (kb) in the 3'-end of the gene...
  86. ncbi Induction of the mouse kappa-opioid receptor gene by retinoic acid in P19 cells
    Jinhua Li
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:39967-72. 2002
    The mouse kappa-opioid receptor (KOR) gene is expressed in mouse embryonal carcinoma P19 cells and induced by retinoic acid (RA) within 24 h. An RA-responsive cis-acting element is identified within promoter I of the KOR gene...
  87. ncbi Expression of functional kappa-opioid receptors on murine dendritic cells
    Annette Kirst
    Institute of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, D 97078, Wurzburg, Germany
    Immunol Lett 84:41-8. 2002
    ..Therefore, dendritic cells might be involved in the interaction of the neuroendocrine hormones and the immune system...
  88. ncbi Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity
    C Gaveriaux-Ruff
    CNRS UPR 9050, ESBS, Universite Louis Pasteur, Illkirch, France
    J Pharmacol Exp Ther 298:1193-8. 2001
    ..Therefore, the postulated inhibitory activity of naltrindole in the graft rejection process is mediated by a target, which remains to be discovered...
  89. ncbi Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow
    K Huang
    Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, Maryland 20892, USA
    Oncogene 13:1567-73. 1996
    ..The high level expression of PTP-K1 mRNA in bone marrow suggests that PTP-K1 may be involved in signal transduction in growth and differentiation of hematopoietic cells...
  90. ncbi Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor
    K Raynor
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia
    J Pharmacol Exp Ther 270:1381-6. 1994
    ..The desensitization of the kappa receptor is dependent on the time and concentration of agonist treatment, is blocked by the kappa-selective antagonist nor-binaltorphimine and is reversible.(ABSTRACT TRUNCATED AT 250 WORDS)..
  91. pmc Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes
    Michael R Bruchas
    Department of Pharmacology, University of Washington, 1959 Pacific Avenue N E, Seattle, WA 98195, USA
    J Biol Chem 281:18081-9. 2006
    AtT-20 cells expressing the wild-type kappa opioid receptor (KOR) increased phospho-p38 MAPK following treatment with the kappa agonist U50,488...
  92. ncbi Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol 29:39-49. 2003
    ..in alcohol preference among mouse strains are related to possible polymorphisms of the kappa-opioid receptor gene (Oprk1)...
  93. doi Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts
    Jason N Peart
    Heart Foundation Research Center, Griffith University, Gold Coast Mail Center, QLD, 9726, Australia
    Basic Res Cardiol 103:454-63. 2008
    ..In summary, kappa-ORs afford cardioprotection primarily when activated prior to and not after reperfusion. This protection may involve activation of the PI3 kinase (PI3K) pathway and mitochondrial (mito) K (ATP) channels...
  94. ncbi Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Brain Res 880:102-8. 2000
    ..test in mutant mice lacking either the mu (exon 1 of MOR-1), delta (exon 2 of DOR-1) or kappa (exon 3 of KOR-1) opioid receptor...
  95. ncbi Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice
    Kh Reeta
    Department of Pharmacology, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110 095, India
    Regul Pept 135:85-90. 2006
    ....

Research Grants8

  1. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  2. AFFINITY LABELS FOR OPIOID RECEPTORS
    Jane V Aldrich; Fiscal Year: 2010
    ..Such information could be crucial in developing novel types of narcotic agents with improved pharmacological profiles and decreased side effects. ..
  3. MAPPING OF ALCOHOL PREFERENCE GENES IN RQI STRAINS
    Csaba Vadasz; Fiscal Year: 2002
    ..Identification of a <1 cM region will allow the identification of candidate genes and ESTs. We will map each identified and confirmed QTL. ..
  4. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
    ..abstract_text> ..
  5. Controlling Apoptosis in Oligondendrocytes
    Pamela Knapp; Fiscal Year: 2005
    ..Specific Aim 4: Biochemical and histological techniques are used to determine whether pathways which are independent of caspase-3 play a significant role in cell loss after SCI. ..
  6. Opioids Modulate Oligodendrocyte Development & Function
    Pamela Knapp; Fiscal Year: 2006
    ..Techniques used include cell culture, immunostaining, in situ hybridization, immunoblot, confocal microscopy and adenoviral transfection. ..
  7. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  8. OPIOID PEPTIDE ANALOGS AS PROBES OF OPIOID RECEPTORS
    JANE ALDRICH; Fiscal Year: 2008
    ..Experience in these areas will be synergistic with Dr. Aldrich's expertise in peptide chemistry and significantly enhance her contributions to research in the area of drug abuse. [unreadable] [unreadable] [unreadable] [unreadable]..