Oprd1

Summary

Gene Symbol: Oprd1
Description: opioid receptor, delta 1
Alias: DOR, DOR-1, Nbor, mDOR, delta-type opioid receptor, D-OR-1, K56, MSL-2, delta 1 opioid receptor
Species: mouse

Top Publications

  1. ncbi Cloning of a delta opioid receptor by functional expression
    C J Evans
    Department of Psychiatry, University of California, School of Medicine, Los Angeles 90024 1759
    Science 258:1952-5. 1992
  2. ncbi Molecular biology and pharmacology of cloned opioid receptors
    R J Knapp
    Department of Pharmacology, University of Arizona, Tucson 85724, USA
    FASEB J 9:516-25. 1995
  3. ncbi Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors
    K Raynor
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104
    Mol Pharmacol 45:330-4. 1994
  4. pmc Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
    M Nishi
    Department of Neurochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Japan
    EMBO J 16:1858-64. 1997
  5. ncbi Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice
    S J Slowe
    Pharmacology Research Group, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
    Brain Res 818:335-45. 1999
  6. pmc G-protein-coupled receptor heterodimerization modulates receptor function
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Nature 399:697-700. 1999
  7. ncbi Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
    Neuron 24:243-52. 1999
  8. ncbi Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
    D Filliol
    1 UPR 9050 CNRS, ESBS Université Louis Pasteur, Illkirch, Strasbourg, France
    Nat Genet 25:195-200. 2000
  9. ncbi Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    Sandy Ghozland
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:1146-54. 2002
  10. ncbi Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice
    Robin J Goody
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guilford, Surrey GU2 7XH, UK
    Brain Res 945:9-19. 2002

Research Grants

  1. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
  2. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
  3. Knockout/congenic strains to map and identify QTL's
    Bruce Herron; Fiscal Year: 2007
  4. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
  5. GENETICS OF VEGF MEDIATED ANGIOGENESIS IN MOUSE SKIN
    Bruce J Herron; Fiscal Year: 2010

Scientific Experts

  • C Gaveriaux-Ruff
  • Amynah A Pradhan
  • J S Mogil
  • Guilin Wang
  • LINDSAY HOUGH
  • Minoru Narita
  • P Sun
  • Mary C Olmstead
  • Vincent David
  • Jolanta H Kotlinska
  • Bruce Herron
  • S Roy
  • H C Liu
  • Brigitte L Kieffer
  • Vladimir I Chefer
  • J A Garcia-Sevilla
  • Frederic Simonin
  • Audrey Matifas
  • Gregory Scherrer
  • Rafael Maldonado
  • Dominique Filliol
  • Julie Le Merrer
  • Dongman Chao
  • Lauren Faget
  • Wendy Walwyn
  • Ian Kitchen
  • Dave Dubois
  • Candice Contet
  • Ying Xia
  • Jermaine D Jones
  • Paul Chu Sin Chung
  • Eric Erbs
  • P L Bigliardi
  • Joshua F Nitsche
  • Y Zhu
  • Kentaro Kaneko
  • Achla Gupta
  • Dominique Massotte
  • B Kest
  • Maria C Olianas
  • Fernando Berrendero
  • Sebastien Granier
  • Traci A Czyzyk
  • Xavier Rezai
  • E Erbs
  • Xiaozhou He
  • John Pintar
  • Yilin Yang
  • Ainhoa Plaza-Zabala
  • J E Pintar
  • Hélène Beaudry
  • YuAn Feng
  • Susruta Majumdar
  • Louis Gendron
  • Hai bo Wang
  • Eirini Maria Georganta
  • Chi Xu
  • Katia Befort
  • Gianfranco Balboni
  • Alia Bazzy-Asaad
  • Zafiroula Georgoussi
  • Leonidas J Leontiadis
  • John E Pintar
  • Richard M van Rijn
  • Malika Benbouzid
  • Tim J Sargeant
  • Lan Bao
  • Zhen Ning Zhang
  • Shao Qiu He
  • Xu Zhang
  • Allan I Basbaum
  • Christopher J Evans
  • Tim G Hales
  • A Juni
  • Herve Boutin
  • Gavril W Pasternak
  • Xavier Nadal
  • Mei Bigliardi-Qi
  • C Le Moine
  • Ping Yee Law
  • Ji Song Guan
  • Christine Börner
  • Lois E McCarthy
  • Jonathan L Vogelman
  • Sandra D Comer
  • Rachel R Luba
  • Miquel Martin
  • Elena Martin-Garcia
  • Pierre Veinante
  • Pauline Charbogne

Detail Information

Publications101 found, 100 shown here

  1. ncbi Cloning of a delta opioid receptor by functional expression
    C J Evans
    Department of Psychiatry, University of California, School of Medicine, Los Angeles 90024 1759
    Science 258:1952-5. 1992
    ..The sequence shows homology to G protein-coupled receptors, in particular the receptors for somatostatin, angiotensin, and interleukin-8...
  2. ncbi Molecular biology and pharmacology of cloned opioid receptors
    R J Knapp
    Department of Pharmacology, University of Arizona, Tucson 85724, USA
    FASEB J 9:516-25. 1995
    ..A molecular model of the human delta opioid receptor is included in this review...
  3. ncbi Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors
    K Raynor
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104
    Mol Pharmacol 45:330-4. 1994
    ..The availability of the cloned receptors will facilitate the identification and development of more specific and selective compounds with greater therapeutic potential and fewer undesirable side effects...
  4. pmc Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
    M Nishi
    Department of Neurochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Japan
    EMBO J 16:1858-64. 1997
    ..On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system...
  5. ncbi Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice
    S J Slowe
    Pharmacology Research Group, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
    Brain Res 818:335-45. 1999
    ..This effect was most notable in the nucleus accumbens and the vertical limb of the diagonal band, and suggests there may be functional interactions between mu- and delta-receptors and kappa1- and delta-receptors in mouse brain...
  6. pmc G-protein-coupled receptor heterodimerization modulates receptor function
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Nature 399:697-700. 1999
    ..Furthermore, the kappa-delta heterodimer synergistically binds highly selective agonists and potentiates signal transduction. Thus, heterodimerization of these GPCRs represents a novel mechanism that modulates their function...
  7. ncbi Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
    Neuron 24:243-52. 1999
    Gene targeting was used to delete exon 2 of mouse DOR-1, which encodes the delta opioid receptor...
  8. ncbi Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
    D Filliol
    1 UPR 9050 CNRS, ESBS Université Louis Pasteur, Illkirch, Strasbourg, France
    Nat Genet 25:195-200. 2000
    ..The mu-, delta- and kappa- opioid receptors (encoded by Oprm, Oprd1 and Oprk1, respectively) mediate the biological activity of opioids...
  9. ncbi Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    Sandy Ghozland
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:1146-54. 2002
    ..Thus, an opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC...
  10. ncbi Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice
    Robin J Goody
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guilford, Surrey GU2 7XH, UK
    Brain Res 945:9-19. 2002
    Using quantitative receptor autoradiography we have determined if deletion of the delta-opioid receptor gene (Oprd1) results in compensatory changes in the expression of other opioid receptors...
  11. ncbi Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
    Miquel Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 17:701-8. 2003
    We have examined responses of mice lacking mu, delta and kappa opioid receptor (MOR, DOR and KOR, respectively) genes, as well as combinatorial mutants, in several pain models...
  12. ncbi Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice
    Vladimir I Chefer
    Integrative Neuroscience Section, DHHS NIH NIDA IRP BNRB INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:1915-22. 2003
    ..in the nucleus accumbens (NAc) of wild-type mice and those with a constitutive deletion of mu (MOR)- or delta (DOR)-opioid receptors. Locomotor activity was assessed in these same animals...
  13. ncbi Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
    Ping Yee Law
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455 0217, USA lawxx001 umn edu
    J Biol Chem 280:11152-64. 2005
    ..expressed mu-opioid receptor (MOR) and the ponasterone A-induced expression of delta-opioid receptor (DOR) in EcR293 cells...
  14. ncbi Neuropathic pain is enhanced in delta-opioid receptor knockout mice
    Xavier Nadal
    Laboratori de Neurofarmacologia Facultat de Ciencies de la Salut i de la Vida Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 23:830-4. 2006
    We have evaluated the possible involvement of delta-opioid receptor (DOR) in the development and expression of neuropathic pain...
  15. ncbi Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing
    Mei Bigliardi-Qi
    Department of Dermatology, CHUV Hôpital Beaumont, BT 440, CH 1011 Lausanne, Switzerland
    Differentiation 74:174-85. 2006
    ..Several findings suggest that the delta-opioid receptor (DOR) and its endogenous ligands (enkephalins) are important players in cell differentiation and proliferation...
  16. pmc Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo
    Gregory Scherrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 103:9691-6. 2006
    ..We created mice where the delta-opioid receptor (DOR) is replaced by an active DOR-EGFP fusion...
  17. pmc Opioid receptors: from binding sites to visible molecules in vivo
    Brigitte L Kieffer
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, F 67400 France INSERM, U596, Illkirch F 67400, France CNRS, UMR7104, Illkirch F 67400, France
    Neuropharmacology 56:205-12. 2009
    ..Importantly, we will identify a number of research directions that are likely to develop during the next decade...
  18. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
    ..Using a DOReGFP reporter mouse we now show that the DOR and MOR are, in fact, expressed by different subsets of primary afferents...
  19. pmc The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake
    Richard M van Rijn
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    Biol Psychiatry 66:777-84. 2009
    ..Despite decades of research, several mysteries surround the pharmacology of these receptors. For example, two pharmacologically defined subtypes of delta receptors exist in vivo...
  20. pmc Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons
    Hai bo Wang
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Proc Natl Acad Sci U S A 107:13117-22. 2010
    ..Importantly, both DOR and MOR agonists reduce depolarization-induced Ca(2+) currents in single small DRG neurons and inhibit afferent C-..
  21. doi Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands
    Chi Xu
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
    J Cell Sci 123:4259-70. 2010
    ..However, such functional differences of ERK disappeared with the mutation of Ser363. Therefore, the present study reveals a crucial role for Ser363 in agonist-specific regulation of ERK activation patterns and functions...
  22. doi Deletion of the δ opioid receptor gene impairs place conditioning but preserves morphine reinforcement
    Julie Le Merrer
    Département de Neurobiologie et Génétique, Institut de Biologie Moleculaire et Cellulaire, Illkirch, France
    Biol Psychiatry 69:700-3. 2011
    ..In the present study, we investigated the impact of δ receptor gene knockout on reinforced conditioned learning under several experimental paradigms...
  23. doi Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia
    Claire Gaveriaux-Ruff
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Neurobiology and Genetic Department, Illkirch F 67400, France
    Pain 152:1238-48. 2011
    ..The conditional knockout of delta-opioid receptor in primary afferent Na(V)1.8 neurons augmented mechanical allodynia in persistent pain models and abolished delta opioid analgesia in these models...
  24. doi Mouse δ opioid receptors are located on presynaptic afferents to hippocampal pyramidal cells
    Xavier Rezai
    Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM UdS, Illkirch, France
    Cell Mol Neurobiol 32:509-16. 2012
    ..In the mouse hippocampus, expression of functional delta opioid receptors is therefore mostly associated with interneurons emphasizing a presynaptic modulatory effect on the pyramidal cell firing rate...
  25. pmc Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus
    E Erbs
    Department of Human Genetics and Translational Medicine, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM UdS, 1 rue Laurent Fries, F 67404 Illkirch Graffenstaden, France
    Neuroscience 221:203-13. 2012
    ..Indeed, they are mostly expressed in parvalbumin-immunopositive neurons both in the Ammon's horn and dentate gyrus. These receptors, therefore, most likely participate in the dynamic regulation of hippocampal activity...
  26. ncbi Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine 90024 7008, USA
    Genomics 28:39-43. 1995
    ..Because the zinc finger proteins encoded by these genes may be involved in regulating other genes that are expressed in lens, they can be considered candidates for the large number of yet unmapped cataract loci...
  27. ncbi Genomic structure of the mouse delta opioid receptor gene
    L B Augustin
    Department of Pharmacology, University of Minnesota, Minneapolis 55455
    Biochem Biophys Res Commun 207:111-9. 1995
    Using mouse delta opioid receptor (DOR) cDNA sequence to probe genomic libraries in bacteriophage lambda and P1 vectors, clones traversing the entire DOR coding sequence and 5' and 3' flanking regions were isolate...
  28. ncbi Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridization
    K Befort
    Ecole Superieure de Biotechnologie de Strasbourg, France
    Genomics 20:143-5. 1994
  29. ncbi Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment
    S Jenab
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Brain Res 691:69-75. 1995
    The antinociceptive potency of the delta opioid receptor (DOR) agonist [D-Ala2]Deltorphin II and the levels of DOR mRNA were measured in mice chronically treated with naltrexone...
  30. ncbi The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation
    X Zhu
    Shanghai Research Center of Life Sciences, Peoples Republic of China
    Biochem Biophys Res Commun 232:513-6. 1997
    ..Their membrane localization and ability to mediate signal transduction were also studied. We conclude that the C-terminus of delta OR is not essential for plasma membrane targeting, ligand specificity, and agonist-dependent activation...
  31. ncbi No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse
    Candice Contet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Parc d innovation, 1 rue Laurent Fries BP 10142, C U de Strasbourg, 67404 Illkirch Cedex, France
    Eur J Pharmacol 492:131-6. 2004
    ..We conclude that the brain epsilon site involves mu, delta and/or kappa receptors, possibly coupled to nonclassical G proteins...
  32. ncbi Nociception increases during opioid infusion in opioid receptor triple knock-out mice
    A Juni
    Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, NY 11367, USA
    Neuroscience 147:439-44. 2007
    ....
  33. ncbi Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia
    Malika Benbouzid
    Institut des Neurosciences Cellulaires et Integratives, Centre National de Recherche Scientifique Université Louis Pasteur, Strasbourg, France
    Biol Psychiatry 63:633-6. 2008
    ..A large body of clinical evidence indicates that antidepressant drugs can also be highly effective against chronic neuropathic pain. However, the mechanism by which these drugs alleviate pain is still unclear...
  34. doi Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling
    Leonidas J Leontiadis
    Laboratory of Cellular Signaling and Molecular Pharmacology, Institute of Biology, National Center for Scientific Research Demokritos, Ag Paraskevi Attikis, Athens, Greece
    Cell Signal 21:1218-28. 2009
    ..Our findings demonstrate that RGS4 plays a key role in G protein coupling selectivity and signaling of the mu- and delta-OmicronRs...
  35. pmc Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons
    Wendy Walwyn
    Department of Psychiatry and Biobehavioral Sciences, Center for Health Sciences, University of California, Los Angeles, CA, USA
    Mol Pharmacol 76:134-43. 2009
    ..Because DAMGO exhibited a similar potency in delta(+/+) and delta(-/-) neurons and caused similar levels of internalization, the role for heterodimerization is probably at the level of receptor biosynthesis...
  36. doi δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice
    Kentaro Kaneko
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan
    Am J Physiol Regul Integr Comp Physiol 306:R265-72. 2014
    ..This suppression was also blocked by centrally administered naltrindole, an antagonist for the δ-receptor, suggesting that rubiscolin-6 suppressed high-fat diet intake via activation of central δ-opioid receptor...
  37. pmc A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks
    Eric Erbs
    Department of Neurogenetics and Translational Medicine, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite de Strasbourg, 1 rue Laurent Fries, BP10142, 67404, Illkirch Cedex, France
    Brain Struct Funct 220:677-702. 2015
    ..Mu (MOR) and delta (DOR) opioid receptors functionally interact in vivo, but whether interactions occur at circuitry, cellular or molecular ..
  38. pmc Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration
    P L Bigliardi
    Institute of Medical Biology, Agency for Science Technology and Research A STAR, Singapore Division of Rheumatology, National University Hospital, University Medicine Cluster, Singapore
    Br J Pharmacol 172:501-14. 2015
    ..Hence, we investigated δ-opioid receptor effects on the expression of several proteins of the desmosomal junction complex and on the migratory behaviour of keratinocytes...
  39. pmc Opioid receptor function is regulated by post-endocytic peptide processing
    Achla Gupta
    From the Department of Pharmacology and Systems Therapeutics and
    J Biol Chem 289:19613-26. 2014
    ..Together, these results support a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2. ..
  40. pmc A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons
    Paul Chu Sin Chung
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, Illkirch, France
    Biol Psychiatry 77:404-15. 2015
    The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory...
  41. doi Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms
    Jermaine D Jones
    Division of Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, 10032, New York, New York
    Am J Addict 25:41-8. 2016
    ..Previous research has identified many genetic polymorphisms that appear to mediate the effects of opioid drugs. However, the relationship between genetic polymorphisms and the severity of opioid withdrawal has not yet been characterized...
  42. pmc Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli
    Hélène Beaudry
    Département de Physiologie et Biophysique, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Neurosci 31:13068-77. 2011
    ..Together, our results indicate that functional MOPRs and DOPRs are both expressed by peptidergic nociceptors...
  43. pmc Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:19778-83. 2011
    ....
  44. pmc Mice lacking δ-opioid receptors resist the development of diet-induced obesity
    Traci A Czyzyk
    Obesity Research, Lilly Research Laboratories, Indianapolis, Indiana, USA
    FASEB J 26:3483-92. 2012
    ..Herein, we investigated whether genetic disruption of the δ-opioid receptor (DOR) also controls energy homeostasis...
  45. pmc Structure of the δ-opioid receptor bound to naltrindole
    Sebastien Granier
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 485:400-4. 2012
    ..Comparison of the address region of the δ-OR with other GPCRs reveals that this structural organization may be a more general phenomenon, extending to other GPCR families as well...
  46. pmc DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex
    Dongman Chao
    The Third Medical College of Soochow University, Changzhou, Jiangsu 213003, PR China
    Exp Neurol 236:228-39. 2012
    Activation of delta-opioid receptors (DOR) is neuroprotective against hypoxic/ischemic injury in the cortex, which is at least partially related to its action against hypoxic/ischemic disruption of ionic homeostasis that triggers ..
  47. pmc Influence of δ-opioid receptors in the behavioral effects of nicotine
    Fernando Berrendero
    Department of Experimental and Health Sciences, Laboratory of Neuropharmacology, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    Neuropsychopharmacology 37:2332-44. 2012
    ..However, this opioid receptor does not participate either in several acute effects of nicotine or in the development of tolerance and physical dependence induced by chronic nicotine administration...
  48. doi Potentiation of dopamine D1-like receptor signaling by concomitant activation of δ- and μ-opioid receptors in mouse medial prefrontal cortex
    Maria C Olianas
    Section of Neurosciences, Department of Biomedical Sciences University of Cagliari, Cagliari, Italy
    Neurochem Int 61:1404-16. 2012
    ..This previously unrecognized synergistic interaction may selectively affect DA D1 transmission at specific postsynaptic sites where the receptors are co-localized and may play a role in prefrontal DA D1 regulation of opioid addiction...
  49. doi Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors
    Julie Le Merrer
    Département de Médecine Translationnelle et Neurogénétique, Institut de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67 404 Illkirch Cedex, France
    Psychopharmacology (Berl) 223:99-106. 2012
    ..Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-))...
  50. ncbi Antisense oligodeoxynucleotides to the cloned delta receptor DOR-1: uptake, stability, and regulation of gene expression
    K M Standifer
    Cotzias Laboratory of NeuroOncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Neurochem 65:1981-7. 1995
    ..antisense oligodeoxynucleotides (ODNs) directed against various domains of the cloned mouse delta receptor DOR-1 reduce delta-opioid receptor binding in vivo and in vitro...
  51. ncbi Identification of kappa- and delta-opioid receptor transcripts in immune cells
    C Gaveriaux
    Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France
    FEBS Lett 369:272-6. 1995
    ..In conclusion, our results lead to the identification of kappa and delta opioid receptor transcripts in immune cells...
  52. ncbi Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C
    G Pei
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 48:173-7. 1995
    ..We conclude that short term desensitization of the delta OR involves phosphorylation of the receptor by one or more G protein-coupled receptor kinases...
  53. ncbi Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase
    R C Tsu
    Department of Biology, Hong Kong University of Science and Technology, Kowloon
    J Neurochem 64:2700-7. 1995
    ..Cotransfection studies revealed that the delta-opioid receptor can utilize Gz to regulate cAMP accumulation and to stimulate the formation of inositol phosphates...
  54. ncbi Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4
    M V Autieri
    Department of Cardiovascular Pharmacy, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Genomics 25:282-4. 1995
    ..The gene encoding F5, termed I2rf5, was mapped using interspecies mouse crosses in close proximity to a number of genes associated with neuronal defects on distal chromosome 4...
  55. ncbi Delta-opioid peptide receptors in muscles from obese diabetic and normal mice
    A A Evans
    Department of Physiology, Medical School, University of Birmingham, UK
    Peptides 16:361-4. 1995
    ..Therefore, the opioid receptor present in skeletal muscle fibers of the mouse is of the delta subtype and the number of these receptors is increased in type II diabetes in the mouse...
  56. ncbi Delta-opioid receptor gene expression in the mouse forebrain: localization in cholinergic neurons of the striatum
    C Le Moine
    EP CNRS 74, Universite de Bordeaux II, France
    Neuroscience 62:635-40. 1994
    ....
  57. ncbi Supraspinal delta opioid receptor mRNA levels are not altered in [D-Ala2]deltorphin II tolerant mice
    B Kest
    Department of Pharmacology, Cornell University Medical College, New York, New York 10021
    J Neurosci Res 39:674-9. 1994
    Delta opioid receptor (DOR) mRNA levels were studied in mice rendered tolerant to [D-Ala2]deltorphin II by 4 days of repeated intracerebroventricular administration (10 micrograms, [tid])...
  58. ncbi Cloning and characterization of the mouse gene encoding mammary-derived growth inhibitor/heart-fatty acid-binding protein
    M Treuner
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Gene 147:237-42. 1994
    ....
  59. ncbi Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis
    D L Kaufman
    Department of Psychiatry, UCLA School of Medicine 90024
    Genomics 19:405-6. 1994
  60. pmc Cloning and functional comparison of kappa and delta opioid receptors from mouse brain
    K Yasuda
    Howard Hughes Medical Institute, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 90:6736-40. 1993
    ....
  61. ncbi Characterization and mapping of a delta opioid receptor clone from NG108-15 cells
    D E Keith
    Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles 90024 1759
    Proc West Pharmacol Soc 36:299-306. 1993
  62. pmc Regional expression and chromosomal localization of the delta opiate receptor gene
    T Bzdega
    Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:9305-9. 1993
    ..The gene, which is present as a single copy, has been mapped to the distal region of mouse Chromosome 4...
  63. ncbi Differential effects of opioids on the proliferation of a macrophage cell line, Bac 1.2F5
    S Roy
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    Cell Immunol 169:271-7. 1996
    ..These studies show that Bac 1.2F5 cells are suitable for the molecular characterization of opioid effects on the proliferation and differentiation of myeloid progenitor cells...
  64. ncbi Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors
    F Noble
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Brain Res 716:107-17. 1996
    ..The results suggest probable differences in the specific neural locations of opioid receptor subtypes in certain inbred strains of mice with varying sensitivities to the behavioral effects of morphine...
  65. ncbi A 3D model of the delta opioid receptor and ligand-receptor complexes
    I Alkorta
    Molecular Research Institute, Palo Alto, CA 94304, USA
    Protein Eng 9:573-83. 1996
    ..These results also allowed identification of key residues as candidates for point mutations for further assessment and refinement of this model as well as preliminary indications of the requirements for recognition of this receptor...
  66. ncbi Expression cloning of a full-length cDNA encoding delta opioid receptor from mouse thymocytes
    M Sedqi
    Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA
    J Neuroimmunol 65:167-70. 1996
    ..The studies represent the first report of a full-length opioid receptor in the immune system...
  67. ncbi Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors
    J S Mogil
    Department of Behavioral Neuroscience and VA Medical Center, Oregon Health Sciences University, Portland 97201, USA
    Pain 70:267-77. 1997
    ..An obvious candidate gene located in this same chromosomal region is Oprd1, which encodes the murine delta-opioid receptor...
  68. ncbi Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption
    J P de Waele
    Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
    Alcohol Clin Exp Res 21:754-62. 1997
    ....
  69. ncbi Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 18:2538-49. 1998
    ..Several examples of possible autocrine and paracrine loops of opioid peptide and receptor expression have been identified, suggesting a role for these local circuits in developmental processes...
  70. ncbi Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice
    B Kest
    Department of Psychology 4S 223, The College of Staten Island City University of New York, 2800 Victory Blvd, Staten Island, NY 10314, USA
    Brain Res 805:131-7. 1998
    ..strain progenitors with respect to delta opioid antinociception, whole-brain receptor binding levels, and mRNA (DOR-1) levels...
  71. pmc Transcriptional regulation of mouse delta-opioid receptor gene
    H C Liu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 274:23617-26. 1999
    Three major types of opioid receptors, mu (MOR), delta (DOR), and kappa (KOR), have been cloned and characterized...
  72. ncbi Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene
    S Clarke
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Brain Res 906:13-24. 2001
    ..There were a small number of region specific changes in the expression of classical opioid receptors that may relate to interdependent function with ORL1...
  73. ncbi Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity
    C Gaveriaux-Ruff
    CNRS UPR 9050, ESBS, Universite Louis Pasteur, Illkirch, France
    J Pharmacol Exp Ther 298:1193-8. 2001
    ..Therefore, the postulated inhibitory activity of naltrindole in the graft rejection process is mediated by a target, which remains to be discovered...
  74. ncbi Transcriptional regulation of mouse delta-opioid receptor gene: role of Ets-1 in the transcriptional activation of mouse delta-opioid receptor gene
    P Sun
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 276:45462-9. 2001
    Previously, we identified a minimum core promoter of the mouse delta-opioid receptor (DOR) gene...
  75. ncbi Antisense oligodeoxynucleotides to mu- and delta-opioid receptor mRNA block the enhanced effects of opioids during intestinal inflammation
    O Pol
    Anesthesiology Research Unit, IMIM, Department of Anesthesiology, Hospital Universitario del Mar, Universidad Autonoma de Barcelona, Spain
    Eur J Pharmacol 428:127-36. 2001
    ....
  76. ncbi Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development
    C Le Moine
    UMR CNRS 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Neuroscience 112:131-9. 2002
    ....
  77. ncbi Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice
    Sian Clarke
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, GU2 7XH UK
    Eur J Neurosci 16:1705-12. 2002
    ..Labelling of the ORL1 receptor with [3H]nociceptin showed region-dependent quantitative increases in triple knockout brains indicating a close relationship between the two systems in specific brain areas...
  78. ncbi Transcriptional regulation of mouse delta-opioid receptor gene. Ikaros-2 and upstream stimulatory factor synergize in trans-activating mouse delta-opioid receptor gene in T cells
    Ping Sun
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Biol Chem 278:2304-8. 2003
    Considerable evidence indicates that transcription of the delta-opioid receptor (dor) gene is correlated with both the expression of DOR on T cells and the capacity of DOR agonists to modulate the immunological functions of the T cell...
  79. ncbi Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice
    Joshua F Nitsche
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:10906-13. 2002
    Previous experiments have shown that mice lacking a functional delta-opioid receptor (DOR-1) gene do not develop analgesic tolerance to morphine...
  80. ncbi Enhanced humoral response in kappa-opioid receptor knockout mice
    Claire Gaveriaux-Ruff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP10142, 67404 Illkirch Cedex, C U de Strasbourg, France
    J Neuroimmunol 134:72-81. 2003
    ..These results show that endogenous activation of kappa-opioid receptors may exert a tonic inhibition of antibody (Ab) response...
  81. ncbi Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration
    J A Garcia-Sevilla
    Laboratori de Neurofarmacologia, Unitat Associada de l Instituto de Neurobiología Ramón y Cajal CSIC, Facultat de Ciencies, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
    Neuropharmacology 46:519-30. 2004
    ..The induction of heterologous receptor adaptations in mu-KO mice may explain this paradoxical effect of morphine...
  82. ncbi The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice
    Gregory Scherrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR7104, Parc d Innovation, 1 rue Laurent Fries BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Eur J Neurosci 19:2239-48. 2004
    ....
  83. ncbi The delta-opioid receptor participates in T-cell development by promoting negative selection
    Lois E McCarthy
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Neuroimmunol 153:91-8. 2004
    The delta-opioid receptor-1 (DOR-1) as well as delta-opioid enkephalin peptides are expressed during maturation of T cells, although the functional significance of their expression remains unclear...
  84. ncbi STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors
    Christine Börner
    Department of Pharmacology and Toxicology, University of Magdeburg, Magdeburg, Germany
    J Neurochem 91:1493-500. 2004
    ..In contrast, the non-canonical STAT6 site of the delta-opioid receptor binds STAT6 with similar high activity as a perfectly palindromic STAT6 site and is strongly inducible by IL-4...
  85. ncbi Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia
    Ji Song Guan
    Institute of Neuroscience, Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China
    Cell 122:619-31. 2005
    ..Plasma-membrane insertion of delta-opioid receptors (DORs) is induced by stimulus-triggered exocytosis of DOR-containing large dense-core vesicles (LDCVs), but how DORs become sorted into the regulated secretory pathway is ..
  86. ncbi Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons
    Wendy Walwyn
    Department of Psychiatry and Biobehavioral Sciences, Center for Health Sciences, University of California, Los Angeles, USA
    Mol Pharmacol 68:1688-98. 2005
    ..However, up-regulation of cell-surface delta receptors induces their coupling to Ca2+ channels. Pharmacological approaches that increase functional delta receptor expression may reveal a novel target for analgesic therapy...
  87. ncbi A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice
    Bruce J Herron
    Genomics Institute, Wadsworth Center, NYS Dept of Health, 465 Jordan Road, Albany, New York 12180, USA
    Nat Genet 37:1210-2. 2005
    ..Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice...
  88. ncbi Age-related emotionality is associated with cortical delta-opioid receptor dysfunction-dependent astrogliosis
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 137:1359-67. 2006
    ..This phenomenon may lead to emotional disorders including aggravated anxiety during normal aging...
  89. ncbi delta-, but not mu-, opioid receptor stabilizes K(+) homeostasis by reducing Ca(2+) influx in the cortex during acute hypoxia
    Dongman Chao
    Department of Pediatrics, Section of Respiratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Physiol 212:60-7. 2007
    Past work has shown that delta-opioid receptor (DOR) activation by [D-Ala(2),D-Leu(5)]-enkephalin (DADLE) attenuated the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation (OGD) in the cortex, while ..
  90. ncbi Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice
    Herve Boutin
    CNRS UMR 6185, Centre Cyceron, Caen, France
    Acta Neuropathol 114:491-500. 2007
    ..Changes in opioidergic receptor expression in these regions may be involved in the long-term consequences of stroke and could be used as biomarker of neuronal alteration through the use of imaging techniques in the clinic...
  91. doi Acute in utero morphine exposure slows G2/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse
    Tim J Sargeant
    School of Biological Sciences, Wellington 6140, New Zealand
    Eur J Neurosci 28:1060-7. 2008
    ..These findings indicate that opioid signalling plays a role in cell cycle progression of both radial glia and basal progenitor cells in vivo in the developing cerebral cortex...
  92. pmc Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task
    Mary C Olmstead
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    PLoS ONE 4:e4410. 2009
    ..time, the role of opioid systems in impulsivity by testing whether inactivation of the mu- (Oprm1) or delta- (Oprd1) opioid receptor gene alters motor impulsivity in mice...
  93. doi Multi-component signaling complexes of the delta-opioid receptor with STAT5B and G proteins
    Eirini Maria Georganta
    Laboratory of Cellular Signaling and Molecular Pharmacology, Institute of Biology, National Centre for Scientific Research Demokritos, 15310 Ag Paraskevi Attikis, Athens, Greece
    Neuropharmacology 59:139-48. 2010
    ..We can thus conclude that STAT5B signaling can be modulated by its coupling with a specific subset of G protein subunits, revealing a novel signaling mechanism for the transcriptional regulation of STAT5B-dependent genes...
  94. doi Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice
    Dave Dubois
    Département de Physiologie et Biophysique, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Eur J Neurosci 32:1921-9. 2010
    ..Consequently, our results suggest that SP is not essential for membrane insertion and for the functional emergence of DOPR...
  95. pmc Effect of delta-opioid receptor over-expression on cortical expression of GABAA receptor alpha1-subunit in hypoxia
    YuAn Feng
    First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    Chin J Physiol 54:118-23. 2011
    Recent studies show that both delta-opioid receptors (DOR) and GABA receptors play a neuroprotective role in the mature cortex...
  96. ncbi delta opioid receptor expression is induced by concanavalin A in CD4+ T cells
    B Miller
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 157:5324-8. 1996
    ..It appears that quiescent CD4+ T cells do not express classic opioid receptors, but the delta-type receptor can be induced upon activation...
  97. ncbi Expression of opioid receptors and ligands in pregnant mouse uterus and placenta
    Y Zhu
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Biol Reprod 59:925-32. 1998
    ..Taken together, these results suggest multiple roles for the opioid receptors and opioid peptides in maternal adaptation to pregnancy and in supporting embryo growth...
  98. ncbi Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice
    F O Risinger
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
    Alcohol Clin Exp Res 22:1234-44. 1998
    ..Some of these genes appear to influence taste sensitivity, whereas others appear to mediate sensitivity to aversive pharmacological effects of ethanol...
  99. ncbi Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine
    V I Chefer
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, DHHS NIH National Institute on Drug Abuse IRP BNRB INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 127:497-503. 2004
    ..of wildtype (WT) C57BL/6J mice and mice with constitutive deletion of ether mu- or delta-opioid receptors (MOR or DOR knockout [KO], respectively). Locomotor activity was assessed in these same animals...
  100. ncbi Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward
    Vincent David
    Centre de Neurosciences Intégratives et Cognitives, CNRS UMR 5228 Universités de Bordeaux 1 et 2, Talence, France
    Neuropsychopharmacology 33:1746-59. 2008
    ..ICSA) to study the rewarding effects of morphine microinjections into the VTA of male and female MOR-/- and DOR-/- mice...

Research Grants5

  1. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
    ..abstract_text> ..
  2. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  3. Knockout/congenic strains to map and identify QTL's
    Bruce Herron; Fiscal Year: 2007
    ..Subcongenic strains will be made for further refinement of the region and to be used as future tools for the eventual positional cloning of these genes. [unreadable] [unreadable]..
  4. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  5. GENETICS OF VEGF MEDIATED ANGIOGENESIS IN MOUSE SKIN
    Bruce J Herron; Fiscal Year: 2010
    ..Our results will improve the validity of testing of mouse models and could lead to the discovery of new therapeutic targets or biomarkers for VEGF mediated therapies. ..