Onecut1

Summary

Gene Symbol: Onecut1
Description: one cut domain, family member 1
Alias: D9Ertd423e, HNF-6, Hfh12, Hnf6, Hnf6b, OC-1, Oc1, hepatocyte nuclear factor 6, HNF-3/forkhead homolog 12, hepatic nuclear factor 6, one cut homeobox 1
Species: mouse

Top Publications

  1. ncbi Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA
    Wanyun Sheng
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 279:33928-36. 2004
  2. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
  3. pmc Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, B 1200 Brussels, Belgium
    Gut 61:1723-32. 2012
  4. ncbi Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
    Miguel A Maestro
    Endocrinology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hum Mol Genet 12:3307-14. 2003
  5. pmc RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors
    Nancy Thompson
    Swiss Institute for Experimental Cancer Researcha and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    Mol Cell Biol 32:1189-99. 2012
  6. pmc Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program
    Floor J Stam
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 139:179-90. 2012
  7. doi Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse
    Agnès Espana
    Universite Catholique de Louvain, Institute of Neuroscience, Laboratory of Neural Differentiation, Brussels, B 1200, Belgium
    J Comp Neurol 520:1424-41. 2012
  8. pmc Onecut 1 and Onecut 2 are potential regulators of mouse retinal development
    Fuguo Wu
    Department of Ophthalmology Ross Eye Institute, University at Buffalo, Buffalo, New York 14203, USA
    J Comp Neurol 520:952-69. 2012
  9. pmc Sox9-haploinsufficiency causes glucose intolerance in mice
    Claire L Dubois
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e23131. 2011
  10. doi Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development
    C Francius
    Universite Catholique de Louvain, Institute of Neuroscience, Brussels, Belgium
    Neuroscience 165:116-29. 2010

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. Molecular response of bile duct cell to bile duct injury
    Ai Xuan Holterman; Fiscal Year: 2005
  3. Foxm1b and HNF-6 regulation of liver injury response
    Ai Xuan Holterman; Fiscal Year: 2006
  4. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  5. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  6. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  7. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

  • Jian Yuan
  • Alexis Poncy
  • Lucie Klimova
  • David E Metzger
  • Hong Fu
  • Christophe E Pierreux
  • Patrick Jacquemin
  • N V Popova
  • Solomon Afelik
  • A Espana
  • Ai-Xuan L Holterman
  • KLAUS KAESTNER
  • Frederic P Lemaigre
  • Frederic Clotman
  • Guy G Rousseau
  • Maureen Gannon
  • Robert H Costa
  • Fuguo Wu
  • Klaus H Kaestner
  • Jillian J Goetz
  • Francisco M Rausa
  • Charles Vanderpool
  • Anna L Means
  • Pierre Paul Prevot
  • Alexandru Simion
  • Mary C Weiss
  • Ben Z Stanger
  • Nicolas Plumb-Rudewiez
  • Peggy Raynaud
  • Vinciane Vanhorenbeeck
  • Yiwei Zong
  • Aline Antoniou
  • Vladimir V Kalinichenko
  • Yu Ping Yang
  • Graham P Hayhurst
  • Tara L Conforto
  • Jie Li
  • Laurence A Lemaire
  • Jean Bernard Beaudry
  • Kelly R Pekala
  • Teagan J Walter
  • Anne Grapin-Botton
  • Emilie Audouard
  • Mark M Emerson
  • Kaoru Yamamoto
  • Stacey S Huppert
  • Francesca Lugani
  • Jessica M Appler
  • Yongjun Tan
  • Xiuqian Mu
  • Luc Bertrand
  • Renzhong Li
  • Mark A Magnuson
  • Darshan Sapkota
  • Floor J Stam
  • Andre J Faure
  • Nancy Thompson
  • Yuval Dor
  • Roland Stein
  • Claire L Dubois
  • Judith Magenheim
  • F P Lemaigre
  • Beatriz Sosa-Pineda
  • C Francius
  • Tomonori Kanazawa
  • Mami Uemura
  • G G Rousseau
  • Tsunekazu Oikawa
  • Hongjie Zhang
  • Richard I Sherwood
  • Ewa Wandzioch
  • Jason R Spence
  • Jennifer M Oliver-Krasinski
  • Hong Soon Kang
  • Elizabeth Tweedie Ables
  • Minhua Wang
  • Laura Wilding Crawford
  • Francois Tronche
  • Michael P Hunter
  • Sabrina Margagliotti
  • Dmitriy Malin
  • Kenneth S Zaret
  • Irene Kyrmizi
  • Aurélie V Poll
  • Helene Strick-Marchand
  • Hiromitsu Nakauchi
  • Elizabeth Tweedie
  • Harufumi Yamasaki
  • R H Costa
  • Douglas E Hughes

Detail Information

Publications92

  1. ncbi Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA
    Wanyun Sheng
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 279:33928-36. 2004
    b>Hepatocyte nuclear factor 6 (HNF-6) belongs to the family of One Cut transcription factors (also known as OC-1) and is essential for the development of the mouse pancreas, gall bladder, and the interhepatic bile ducts...
  2. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
    ..In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts. Here, we investigated duct development in mouse liver and characterized the role of the SRY-related HMG box transcription factor 9 (SOX9)...
  3. pmc Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, B 1200 Brussels, Belgium
    Gut 61:1723-32. 2012
    ..In this study, the role of the ductal transcription factors hepatocyte nuclear factor 6 (HNF6, also known as Onecut1) and SRY-related HMG box factor 9 (Sox9) in ADM was investigated.
  4. ncbi Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
    Miguel A Maestro
    Endocrinology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hum Mol Genet 12:3307-14. 2003
    ..We furthermore show that Hnf1beta expression is markedly reduced in early pancreatic epithelial cells of Hnf6-deficient mice, in which formation of Ngn3+ cells is defective...
  5. pmc RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors
    Nancy Thompson
    Swiss Institute for Experimental Cancer Researcha and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    Mol Cell Biol 32:1189-99. 2012
    ..Pdx1, Nkx6.1, and Onecut1 are also direct PTF1a targets whose expression is promoted by PTF1a...
  6. pmc Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program
    Floor J Stam
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 139:179-90. 2012
    ..We show that the selective activation of the Onecut transcription factors Oc1 and Oc2 during the first wave of V1 interneuron neurogenesis is a key step in the RC differentiation program...
  7. doi Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse
    Agnès Espana
    Universite Catholique de Louvain, Institute of Neuroscience, Laboratory of Neural Differentiation, Brussels, B 1200, Belgium
    J Comp Neurol 520:1424-41. 2012
    ..Hence, Onecut factors are markers of the A13 nucleus throughout embryonic development. They are dispensable for the first phase of A13 development but are required for the second phase of development and for maintenance of this nucleus...
  8. pmc Onecut 1 and Onecut 2 are potential regulators of mouse retinal development
    Fuguo Wu
    Department of Ophthalmology Ross Eye Institute, University at Buffalo, Buffalo, New York 14203, USA
    J Comp Neurol 520:952-69. 2012
    Our current study focuses on the expression of two members of the onecut transcription factor family, Onecut1 (Oc1) and Onecut2 (Oc2), in the developing mouse retina...
  9. pmc Sox9-haploinsufficiency causes glucose intolerance in mice
    Claire L Dubois
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e23131. 2011
    ..suggested that Sox9 controls expression of a network of important developmental regulators, including Tcf2/MODY5, Hnf6, and Foxa2, in pancreatic progenitor cells...
  10. doi Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development
    C Francius
    Universite Catholique de Louvain, Institute of Neuroscience, Brussels, Belgium
    Neuroscience 165:116-29. 2010
    The Onecut (OC) transcription factors, namely Hepatocyte nuclear factor 6 (HNF-6), OC-2 and OC-3, are transcriptional activators expressed in liver, pancreas and nervous system during development...
  11. pmc Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation
    Hongjie Zhang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 0475, USA
    Mech Dev 126:958-73. 2009
    Within the developing pancreas Hepatic Nuclear Factor 6 (HNF6) directly activates the pro-endocrine transcription factor, Ngn3...
  12. pmc The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:1888-98. 2009
    ..occupies an evolutionarily conserved enhancer region of Ngn3 and interacts with the transcription factor one cut homeobox 1 (Hnf6) to activate this enhancer...
  13. doi Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus
    A Espana
    Universite Catholique de Louvain, Institute of Neuroscience, Laboratory of Neural Differentiation, avenue Hippocrate 55 box B1 55 11, Brussels B 1200, Belgium
    Mol Cell Neurosci 50:93-102. 2012
    ..Hence, we propose that OC factors are required at early developmental stages for differentiation of the MTN neurons that are in turn necessary for maintenance of the LC...
  14. ncbi Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver
    Nicolas Plumb-Rudewiez
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Hepatology 40:1266-74. 2004
    ..We observed that Foxa1 expression was upregulated in the liver of Hnf6(-/-) mouse embryos and in bipotential mouse embryonic liver (BMEL) cell lines derived from embryonic Hnf6(-/-) ..
  15. pmc Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
    C Haumaitre
    Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:1490-5. 2005
    ..This study provides further insights into early molecular events controlling pancreas development and may contribute to the development of cell-replacement strategies for diabetes...
  16. pmc Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis
    Laura Wilding Crawford
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 3:e1611. 2008
    ..Previous studies have shown that transgenic over-expression of the transcription factor Hnf6 specifically in the pancreatic endocrine cell lineage resulted in disruptions in islet morphogenesis, including ..
  17. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
    ..Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages...
  18. ncbi The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  19. ncbi Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation
    Vinciane Vanhorenbeeck
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Dev Biol 305:685-94. 2007
    ..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation...
  20. ncbi The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Gastroenterology 130:532-41. 2006
    ..Here, we investigate the transcriptional mechanisms that control pancreatic duct development by addressing the role of the transcription factor hepatocyte nuclear factor (HNF)-6...
  21. pmc Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration
    Yongjun Tan
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607 7170, USA
    Gastroenterology 130:1283-300. 2006
    The hepatocyte nuclear factor 6 (HNF6 or ONECUT-1) protein is a cell-type specific transcription factor that regulates expression of hepatocyte-specific genes...
  22. ncbi Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells
    Elizabeth Tweedie
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, 2220 Pierce Ave, 746 PRB, Nashville, TN 37232 6303, USA
    Diabetes 55:3264-70. 2006
    The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for proper development of islet beta-cells...
  23. ncbi The onecut transcription factor HNF6 is required for normal development of the biliary tract
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Development 129:1819-28. 2002
    ..Previous work has shown that the onecut transcription factor HNF6 is expressed in hepatoblasts and in the gallbladder primordium...
  24. ncbi The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas
    F Rausa
    Department of Biochemistry and Molecular Biology, University of Illinois at Chicago 60612 7334, USA
    Dev Biol 192:228-46. 1997
    ..We used interspecific backcross analysis to determine that murine Hnf6 gene is located in the middle of mouse chromosome 9...
  25. ncbi HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors
    C Landry
    Hormone and Metabolic Research Unit, International Institute of Cellular and Molecular Pathology, Brussels, Belgium
    Dev Biol 192:247-57. 1997
    ....
  26. pmc The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression
    U Samadani
    Department of Biochemistry, University of Illinois at Chicago, 60612 7334, USA
    Mol Cell Biol 16:6273-84. 1996
    ..These studies suggest that HNF-6 may regulate hepatocyte-specific genes and may play a role in epithelial cell differentiation of gut endoderm via regulation of HNF-3(beta)...
  27. pmc Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
    P Jacquemin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 1200 Brussels, Belgium
    Mol Cell Biol 20:4445-54. 2000
    b>Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain transcription factors...
  28. ncbi Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function
    M Gannon
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 127:2883-95. 2000
    We used transgenesis to explore the requirement for downregulation of hepatocyte nuclear factor 6 (HNF6) expression in the assembly, differentiation, and function of pancreatic islets...
  29. ncbi OC-3, a novel mammalian member of the ONECUT class of transcription factors
    Vinciane Vanhorenbeeck
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, 75 Avenue Hippocrate, Brussels, B 1200, Belgium
    Biochem Biophys Res Commun 292:848-54. 2002
    ..Our earlier work on HNF-6 and the expression patterns of the three mammalian ONECUT genes suggest that they all participate to the control of organ development from the foregut and midgut endoderm...
  30. pmc Onecut1 is essential for horizontal cell genesis and retinal integrity
    Fuguo Wu
    Department of Ophthalmology Ross Eye Institute and Developmental Genomics Group, New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York 14203, USA
    J Neurosci 33:13053-65, 13065a. 2013
    ..Previously, we showed that Onecut 1 (Oc1), an atypical homeodomain transcription factor, is expressed in developing horizontal cells (HCs) and retinal ..
  31. pmc Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors
    Mark M Emerson
    Departments of Genetics and Ophthalmology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 26:59-72. 2013
    ..Molecular analysis of ThrbCRM1 revealed that it is combinatorially regulated by the Otx2 and Onecut1 transcription factors. Onecut1 is sufficient to induce cells with the earliest markers of cones and HCs...
  32. ncbi The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Dev Biol 258:105-16. 2003
    ..Indeed, the pancreas of Hnf6(-/-) mice was hypoplastic...
  33. ncbi The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Biol Chem 279:51298-304. 2004
    ..hepatocyte nuclear factor-6 (HNF-6), which controls pancreas and liver development as shown in our previous work on Hnf6 knock-out embryos...
  34. pmc Loss of HNF6 expression correlates with human pancreatic cancer progression
    Kelly R Pekala
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Lab Invest 94:517-27. 2014
    ..Transcriptional regulation of this progression is poorly understood. In mouse, the hepatic nuclear factor 6 (Hnf6) transcription factor is expressed in ductal cells and at lower levels in acinar cells of the adult ..
  35. pmc Onecut1 and Onecut2 play critical roles in the development of the mouse retina
    Jillian J Goetz
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 9:e110194. 2014
    ..In this study, we show that two of those factors, Onecut1 and Onecut2, are expressed during mouse retinal development...
  36. pmc Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj
    Teagan J Walter
    Divisions of Gastroenterology, Hepatology, and Nutrition and Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Pathol 184:1479-88. 2014
    ..Notch signaling and Hnf6 have each been shown to be important for the morphogenesis of IHBDs in mice...
  37. ncbi The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
    Development . 2016
    ..Therefore, trans-regulatory integration through the mammal-restricted Area II mediates a surprisingly extensive range of progenitor and β-cell-specific functions of the Pdx1 gene...
  38. doi Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα
    Jie Li
    Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China
    Biochem Pharmacol 93:92-103. 2015
    ..We investigated the roles of HNF6, C/EBPα, and RXRα in the regulation of human female-predominant CYP3A4, mouse female-specific CYP3A41, and rat ..
  39. doi Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development
    Solomon Afelik
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, NE3 251, 9500 Euclid Avenue, Cleveland, OH 44195, United States Electronic address
    Dev Biol 399:204-17. 2015
    ..of endocrine and acinar cells, leading to cystic epithelial metaplasia expressing ductal markers including Sox9, Hnf6 and Hnf1β...
  40. doi Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis
    Laurence A Lemaire
    DanStem, University of Copenhagen, 3B Blegdamsvej, Copenhagen N DK 2200, Denmark ISREC, Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne CH 1015, Switzerland
    Development 142:858-70. 2015
    ..We show that BICC1 functions downstream of ONECUT1 in the pathway controlling both NEUROG3(+) endocrine cell production and ductal morphogenesis, and suggest a new ..
  41. doi Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development
    Lucie Klimova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 14420 Prague 4, Czech Republic Electronic address
    Dev Biol 402:48-60. 2015
    ..In this study, we identified two transcription factors of the Onecut family, Onecut1 and Onecut2, as Pax6 downstream-acting factors...
  42. pmc Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver
    Tara L Conforto
    Division of Cell and Molecular Biology, Department of Biology and Bioinformatics Program, Boston University, Boston, Massachusetts 02215
    Mol Endocrinol 29:1286-302. 2015
    ..to liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas HNF6 is expressed at similar levels in male and female liver...
  43. pmc A novel function of Onecut1 protein as a negative regulator of MafA gene expression
    Kaoru Yamamoto
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, 565 0871 Suita, Japan
    J Biol Chem 288:21648-58. 2013
    ..An adenovirus-mediated overexpression study clearly demonstrated that Onecut1 suppresses the promoter activity of MafA through the Foxa2-binding cis-element on the MafA enhancer region (named ..
  44. doi The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development
    Emilie Audouard
    Universite Catholique de Louvain, Institute of Neuroscience, Laboratory of Neural Differentiation, Brussels, Belgium
    Mol Cell Neurosci 56:159-68. 2013
    ..Adult Hnf6 mutant mice exhibit locomotion defects characterized by hindlimb muscle weakness, abnormal gait and defective ..
  45. pmc Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 100:5034-9. 2003
    ..Our findings suggest that efficient induction of insulin production in intestinal epithelial cells by GLP-1-(1-37) could represent a new therapeutic approach to diabetes mellitus...
  46. pmc Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo
    Charles Vanderpool
    Department of Pediatrics, D Brent Polk Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN 37232 0494, USA
    Hepatology 55:233-43. 2012
    ..In this in vivo model, simultaneous loss of both HNF-6 and RBP-J results in down-regulation of both HNF-1β and Sox9 (sex determining region Y-related HMG box transcription factor 9)...
  47. pmc The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation
    David E Metzger
    Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1056 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 139:1447-56. 2012
    ....
  48. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  49. pmc Gata3 is a critical regulator of cochlear wiring
    Jessica M Appler
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 33:3679-91. 2013
    ..As the first auditory-specific regulator of SGN development, Gata3 provides a useful molecular entry point for efforts to engineer SGNs for the restoration of hearing...
  50. pmc A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse
    Francesca Lugani
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS Genet 9:e1003206. 2013
    ..This striking example of an enhancer mutation resulting in profound developmental defects suggests that disruption of conserved regulatory elements may also contribute to human malformation syndromes...
  51. ncbi HNF-6-independent differentiation of mouse embryonic stem cells into insulin-producing cells
    N Houard
    HORM Université Catholique de Lourain and Institute of Cellular Pathology, 75 Avenue Hippocrate, box 7529, 1200 Brussels, Belgium
    Diabetologia 46:378-85. 2003
    ....
  52. pmc Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium
    Judith Magenheim
    Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Dev Biol 359:26-36. 2011
    ..These results uncover a novel layer of regulation coordinating pancreas morphogenesis and endocrine/exocrine differentiation, and suggest ways to enhance the yield of beta cells from stem cells...
  53. ncbi Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes
    Andrea Jochheim
    Hannover Medical School, Center of Internal Medicine, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
    Int J Dev Biol 48:23-9. 2004
    ..With sophisticated differentiation protocols, hepatic gene expression can be induced in a proportion of ES cells with gene expression patterns similar to early fetal liver...
  54. ncbi Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
    Hideyuki Yoshitomi
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Development 131:807-17. 2004
    ..Additionally, we find that endothelial cells are necessary for the induction of both the insulin and glucagon genes...
  55. ncbi Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci
    N V Popova
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, VC 15, New York, NY 10032, USA
    Curr Top Microbiol Immunol 280:111-37. 2004
    ....
  56. ncbi Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200, Brussels, Belgium
    Gene Expr Patterns 3:639-44. 2003
    ..The human genome contains three Onecut paralogues, Hnf6 (also called Oc1), Oc2 and Oc3...
  57. ncbi The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver
    Caroline Bouzin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    J Immunol 171:1297-303. 2003
    ..Hemopoietic cells from hnf6(-/-) fetal liver could reconstitute the lymphoid system when injected into scid mice...
  58. ncbi The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors
    Laura Wilding
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA
    Diabetes Metab Res Rev 20:114-23. 2004
    ..Here, we provide speculation as to the role of pdx1 and HNF6 in these different stages of pancreatic endocrine cell development...
  59. ncbi Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis
    Natalia V Popova
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Carcinogenesis 24:417-25. 2003
    ....
  60. pmc Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding
    Francisco M Rausa
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell Biol 23:437-49. 2003
    ..This is the first reported example of a liver-enriched transcription factor (HNF-6) functioning as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2...
  61. ncbi Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm
    Zoe Burke
    Department of Genetics, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mech Dev 118:147-55. 2002
    ..This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm...
  62. ncbi Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6
    V J Lannoy
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Diabetologia 45:1136-41. 2002
    ..of the ONECUT family of transcription factors, are present in the hepatic promoter of the glucokinase gene and hnf6 knockout mice are diabetic [corrected]...
  63. ncbi Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction
    Ai Xuan L Holterman
    Department of Surgery, Division of Pediatric Surgery, University of Illinois at Chicago, 60607 7170, USA
    Hepatology 35:1392-9. 2002
    b>Hepatocyte nuclear factor 6 (HNF-6) is a member of the one cut family of transcription factors and potentially regulates expression of numerous target genes important for hepatocyte function...
  64. ncbi Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development
    Vladimir V Kalinichenko
    Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 277:12369-74. 2002
    ....
  65. ncbi Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage
    V W Keng
    Graduate School of Bioagricultural Sciences, Chikusa ku, Nagoya, 464 8601, Japan
    Biochem Biophys Res Commun 276:1155-61. 2000
    ..Expression of transcription factors involved in hepatocyte differentiation, hepatocyte nuclear factor (Hnf)3beta, Hnf6, Hnf4alpha and Hnf1alpha, were restricted to the capsule and internal matrix-like structure in the mutant liver and ..
  66. ncbi The Drosophila homolog of Onecut homeodomain proteins is a neural-specific transcriptional activator with a potential role in regulating neural differentiation
    D N Nguyen
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Mech Dev 97:57-72. 2000
    ..In support of this notion, overexpression of a putative dominant negative form of D-Onecut during eye development does not affect early cell fate specification, but severely affects photoreceptor differentiation...
  67. pmc Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Genes Dev 13:495-504. 1999
    ..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo...
  68. ncbi In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryos
    F M Rausa
    Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, 60612 7334, USA
    Methods 16:29-41. 1998
    ..We discuss these expression patterns with respect to specification of hepatocytes and differentiation of the endocrine and exocrine pancreas...
  69. pmc Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter
    M Rastegar
    Hormone and Metabolic Research Unit, Louvain University Medical School and Christian de Duve Institute of Cellular Pathology ICP, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Biochem J 334:565-9. 1998
    b>Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a family of tissue-specific transcription factors characterized by a bipartite DNA-binding domain consisting of a single cut domain and a novel type of homeodomain...
  70. pmc Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development
    Jean Bernard Beaudry
    box 7529, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Mol Cell Biol 26:6037-46. 2006
    ..In this context we investigate here the role of the LETF hepatocyte nuclear factor 6 (HNF-6; also called Onecut-1) during hepatocyte differentiation...
  71. pmc The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis
    Michael P Hunter
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Dev Biol 308:355-67. 2007
    ..led to embryonic lethality and resulted in a small and cystic liver with loss of Hnf4alpha and Hnf6 expression in early hepatoblasts...
  72. ncbi A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
    Aurélie V Poll
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Diabetes 55:61-9. 2006
    ..Hepatocyte nuclear factor-6 (HNF6) is a key player in this network, because it controls the initiation of the expression of pancreatic and duodenal ..
  73. pmc Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2
    Nir E Rubins
    Department of Genetics, University of Pennsylvania, Philadelphia, 19104, USA
    Mol Cell Biol 25:7069-77. 2005
    A complex network of hepatocyte nuclear transcription factors, including HNF6 and Foxa2, regulates the expression of liver-specific genes. The current model, based on in vitro studies, suggests that HNF6 and Foxa2 interact physically...
  74. pmc Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice
    Minhua Wang
    RUSH Univ Medical Center, Depts of Pediatrics and Surgery, 1725 W Harrison St, Suite 718, Chicago, IL, USA
    Am J Physiol Gastrointest Liver Physiol 295:G357-66. 2008
    ..This was associated with enhanced serum albumin levels. In conclusion, the GH/HNF-6 axis is a potential in vivo mechanism underlying GH diverse function in the liver to modulate the liver repair response to BDL...
  75. pmc Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells
    Graham P Hayhurst
    Unité de Génétique de la Différenciation, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
    J Hepatol 49:384-95. 2008
    ..To specify roles of HNF 4 alpha in mouse liver development, we have analyzed the ex vivo morphogenetic potential of HNF4 alpha-null embryonic hepatic cells...
  76. pmc Transcriptional dynamics of endodermal organ formation
    Richard I Sherwood
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Dev Dyn 238:29-42. 2009
    ..These results contribute to understanding the mechanism of endodermal organogenesis and should assist efforts to replicate this process using pluripotent stem cells...
  77. doi Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
    Tsunekazu Oikawa
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 136:1000-11. 2009
    ..The expression and functional roles of Sall4 during liver development have not been elucidated. We here provide their first description in hepatoblasts...
  78. pmc Plasticity and expanding complexity of the hepatic transcription factor network during liver development
    Irene Kyrmizi
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, 711 10 Herakleion, Crete, Greece
    Genes Dev 20:2293-305. 2006
    ..The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes...
  79. pmc Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression
    Dmitriy Malin
    The University of Chicago, Division of the Biological Sciences, Department of Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Mol Cell Biol 27:2486-98. 2007
    ..Foxf1 plays an essential role in mesenchyme migration by transcriptionally regulating Itgbeta3...
  80. pmc Dynamic signaling network for the specification of embryonic pancreas and liver progenitors
    Ewa Wandzioch
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 324:1707-10. 2009
    ..These findings may enhance progenitor cell specification from stem cells for biomedical purposes and can help explain incomplete programming in stem cell differentiation protocols...
  81. pmc Sox17 regulates organ lineage segregation of ventral foregut progenitor cells
    Jason R Spence
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Cell 17:62-74. 2009
    ..Restricting SOX17+ biliary progenitor cells to the ventral region of the gut requires the notch effector Hes1. Our results highlight the role of Sox17 and Hes1 in patterning and morphogenetic segregation of ventral foregut lineages...
  82. ncbi Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator
    Francisco M Rausa
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607, USA
    J Biol Chem 279:43070-6. 2004
    We previously demonstrated that the formation of complexes between the DNA binding domains of the hepatocyte nuclear factor 6 (HNF6) and Forkhead Box a2 (Foxa2) transcription factors resulted in synergistic transcriptional activation of ..
  83. pmc Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression
    Hong Soon Kang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 29:6366-79. 2009
    ..In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function...
  84. doi MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2
    Alexandru Simion
    Universite Catholique de Louvain, de Duve Institute, 75 Avenue Hippocrate 7529, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 391:293-8. 2010
    ..These results indicate that the expression of regulators of liver and pancreas development is modulated by microRNAs. They also suggest a developmental role for miR-495 and miR-218...
  85. doi Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis
    Mami Uemura
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 391:357-63. 2010
    ..Our findings show that Sox17 functions cell-autonomously to specify gallbladder/bile-duct in the mouse embryo...
  86. doi Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney
    Tomonori Kanazawa
    Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Dev Dyn 239:1145-54. 2010
    ..These results suggest the possibility that Hnf4alpha plays an important role in the regulation of the cell survival at the CM stage in nephrogenesis...
  87. ncbi Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver
    Nadege Briancon
    Unité de Génétique de la Différenciation, URA 2578 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris Cedex 15 75724, France
    J Biol Chem 279:33398-408. 2004
    ..site associated with P2 activity that is still retained in adult liver, contains functional HNF1 and HNF6 binding sites and confers full promoter activity in transient transfections...
  88. pmc Notch signaling controls liver development by regulating biliary differentiation
    Yiwei Zong
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 136:1727-39. 2009
    ..These results reconcile previous conflicting reports about the role of Notch during liver development and suggest that Notch acts by coordinating biliary differentiation and morphogenesis...
  89. ncbi An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Dev Biol 290:189-99. 2006
    ..in the dorsal pancreatic bud and appears genetically redundant with a role for the transcription factor gene HNF6 in promoting the induction of Pdx-1-positive dorsal endoderm...
  90. ncbi GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development
    Erin B Harmon
    Department of Developmental Biology, Stanford University, Stanford, CA 94305 5329, USA
    Development 131:6163-74. 2004
    ..Thus, our studies reveal mechanisms by which GDF11 regulates the production and maturation of islet progenitor cells in pancreas development...
  91. ncbi The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ....
  92. ncbi Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression
    Harufumi Yamasaki
    Department of Biology, Faculty of Science, Shizuoka University, 836 Oya, Surugaku, Shizuoka City, Shizuoka 422 8529, Japan
    Development 133:4233-43. 2006
    ..cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6. In the knockout mouse liver at midgestation stages, pseudoglandular structures were abundantly induced in the ..

Research Grants7

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. Molecular response of bile duct cell to bile duct injury
    Ai Xuan Holterman; Fiscal Year: 2005
    ..Bile duct specific target gene mRNA and protein expression will be assessed and the effect on the development of biliary fibrosis will be determined. ..
  3. Foxm1b and HNF-6 regulation of liver injury response
    Ai Xuan Holterman; Fiscal Year: 2006
    ..The potential of salvaging failed liver, improving the quality of life or extending survival of patients with liver insufficiency using these therapeutic strategies is far reaching. ..
  4. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  5. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  7. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..