Ocln

Summary

Gene Symbol: Ocln
Description: occludin
Alias: AI503564, Ocl, occludin
Species: mouse

Top Publications

  1. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
  2. ncbi Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin
    A Schmidt
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Biochem Biophys Res Commun 288:1194-9. 2001
  3. pmc Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice
    G Kostka
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Mol Cell Biol 21:7025-34. 2001
  4. ncbi Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1
    Olga V Volpert
    Department of Urology and RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Cell 2:473-83. 2002
  5. pmc The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
    Martin J Barron
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Hum Mol Genet 17:3509-20. 2008
  6. pmc Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues
    Y Ando-Akatsuka
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 133:43-7. 1996
  7. pmc Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
    M Saitou
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 141:397-408. 1998
  8. ncbi Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Invest Dermatol 110:862-6. 1998
  9. pmc A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    M Furuse
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 143:391-401. 1998
  10. pmc Complex phenotype of mice lacking occludin, a component of tight junction strands
    M Saitou
    Department of Cell Biology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 11:4131-42. 2000

Research Grants

Scientific Experts

  • Ahmed H K El-Hashash
  • Shin ichiro Kitajiri
  • Joyce Lloyd
  • Richard Daneman
  • Christina M Van Itallie
  • Daniel J Dumont
  • Mikio Furuse
  • Matthew Campbell
  • Jörg Dieter Schulzke
  • B Sheth
  • Kazumasa Morita
  • Alexander M Simon
  • PAUL R BRAKEMAN
  • Scott J Parkinson
  • Makoto Osanai
  • S Citi
  • D G Cyr
  • Masanori Takehashi
  • Mito Kanatsu-Shinohara
  • Abdul Soofi
  • Svetlana M Stamatovic
  • Amanda M Marchiando
  • Shoichiro Tsukita
  • Ingolf E Blasig
  • Francisco Barrionuevo
  • Masaki Hata
  • Myung Chan Gye
  • Junichi Ikenouchi
  • Akiko Iizuka-Kogo
  • Takashi Shinohara
  • Xuwen Liu
  • Noriyuki Nishimura
  • Caroline M Weight
  • Jimmi Cording
  • Oh oka Kyoko
  • Liwei Xie
  • Zlatko Kopecki
  • Eileen L Whiteman
  • Tia DiTommaso
  • Su Ren Chen
  • Jasmin Kranz
  • Sebastian Seidl
  • Gregory R Dressler
  • G Youssef
  • Samriddha Ray
  • Kai M Schmidt-Ott
  • Hartwig Wolburg
  • Karen L Edelblum
  • Li Chin Yao
  • Kozo Nakai
  • Jerrold R Turner
  • M Saitou
  • Nina Kirschner
  • Sandra Ciesek
  • Jorge Ivan Alvarez
  • Rana Al-Sadi
  • Christina M Van Itallie
  • Carla Danussi
  • Le Shen
  • Christopher R Weber
  • Seiji Takashima
  • J D Growney
  • Linlin Su
  • Isabelle Plante
  • Gwang Jin Kim
  • Max Werth
  • Masatomo Kusaka
  • Harold Kim
  • Ken Kobayashi
  • Mary C O'Driscoll
  • Harry Scherthan
  • Florian Guillou
  • Ina Georg
  • Gerd Scherer
  • Preethi Vijayaraj
  • Setsuko Sahara
  • Azeb Tadesse Argaw
  • Magali Saint-Geniez
  • Eniko Kokai
  • Neal E Beeman
  • Juliane K Walter
  • Larissa Lozovatsky
  • Feng Chen
  • Takao Senda
  • Tatsuya Katsuno
  • Carien M Niessen
  • Masaru Yamamoto
  • Martin J Barron
  • Zhihui Zhong
  • Momina Mirza

Detail Information

Publications109 found, 100 shown here

  1. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
    ..We have used in vivo imaging and transgenic mice expressing fluorescent-tagged occludin and ZO-1 fusion proteins to link occludin endocytosis to TNF-induced tight junction regulation...
  2. ncbi Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin
    A Schmidt
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Biochem Biophys Res Commun 288:1194-9. 2001
    ..spectroscopy was applied to study in real time, the interaction between the tight junction proteins ZO-1 and occludin. To imitate the morphology of tight junctions, a cytosolic tail of mouse occludin was immobilised at the sensor ..
  3. pmc Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice
    G Kostka
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Mol Cell Biol 21:7025-34. 2001
    ..The data indicate a strong but restricted abnormality in some endothelial compartments which, together with some kidney and lung defects, may be responsible for early death...
  4. ncbi Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1
    Olga V Volpert
    Department of Urology and RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Cell 2:473-83. 2002
    ..This decrease was completely reversed by a TSP-1 neutralizing antibody. We conclude that TSP-1 is a major target for Id1 effects on angiogenesis...
  5. pmc The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
    Martin J Barron
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Hum Mol Genet 17:3509-20. 2008
    ..Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization...
  6. pmc Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues
    Y Ando-Akatsuka
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 133:43-7. 1996
    b>Occludin has been identified from chick liver as a novel integral membrane protein localizing at tight junctions (Furuse, M., T. Hirase, M. Itoh, A. Nagafuchi, S. Yonemura, Sa. Tsukita, and Sh. Tsukita. 1993. J. Cell Biol. 123:1777-1788)...
  7. pmc Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
    M Saitou
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 141:397-408. 1998
    b>Occludin is the only known integral membrane protein of tight junctions (TJs), and is now believed to be directly involved in the barrier and fence functions of TJs...
  8. ncbi Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Invest Dermatol 110:862-6. 1998
    b>Occludin is an integral membrane protein that is concentrated at tight junctions (zonulae occludentes) in simple epithelial cells...
  9. pmc A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    M Furuse
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 143:391-401. 1998
    Three integral membrane proteins, clau- din-1, -2, and occludin, are known to be components of tight junction (TJ) strands. To examine their ability to form TJ strands, their cDNAs were introduced into mouse L fibroblasts lacking TJs...
  10. pmc Complex phenotype of mice lacking occludin, a component of tight junction strands
    M Saitou
    Department of Cell Biology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 11:4131-42. 2000
    b>Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the generation and analysis of mice carrying a null mutation in the occludin gene...
  11. ncbi The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch
    Andreas Traweger
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    J Biol Chem 277:10201-8. 2002
    ..Recent evidence confirms the notion that occludin, a four-pass integral plasma-membrane protein, is a functional component of the paracellular barrier...
  12. ncbi Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 116:1959-67. 2003
    ..Claudins and occludin are integral membrane proteins localized at tight junctions, which are responsible for establishing and ..
  13. ncbi Rab13 mediates the continuous endocytic recycling of occludin to the cell surface
    Shinya Morimoto
    Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Biol Chem 280:2220-8. 2005
    ..b>Occludin and claudins are integral membrane proteins comprising TJ strands and are thought to be responsible for ..
  14. ncbi Epithelial transport and barrier function in occludin-deficient mice
    J D Schulzke
    Department of Gastroenterology, Campus Benjamin Franklin, Charité Universitary Medicine Berlin, Germany
    Biochim Biophys Acta 1669:34-42. 2005
    This study aimed at functional characterization of the tight junction protein occludin using the occludin-deficient mouse model.
  15. pmc Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 171:939-45. 2005
    ..These findings indicate the critical function of tricellulin for formation of the epithelial barrier...
  16. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
  17. pmc Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells
    Svetlana M Stamatovic
    Departments of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:19053-66. 2009
    ..It investigates the potential role of selective internalization of TJ transmembrane proteins (occludin and claudin-5) in increased permeability of the brain endothelial barrier in vitro...
  18. doi CD44 regulates tight-junction assembly and barrier function
    Nina Kirschner
    Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Invest Dermatol 131:932-43. 2011
    ..Taken together, the results reveal an important function for CD44 in the assembly and function of TJs, suggesting their involvement in the skin barrier phenotype of CD44 KO mice...
  19. ncbi MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis
    Lin Zhang
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Mol Vis 9:584-93. 2003
    ..To study the in vivo role of MEK kinase 1 (MEKK1) in corneal development...
  20. ncbi The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1
    Sebastian L Müller
    Forschungsinstitut fur Molekulare Pharmakologie, 13125 Berlin, Charite Campus Mitte, 10117 Berlin, Germany, and Charité Campus Benjamin Franklin, 12203 Berlin, Germany
    J Biol Chem 280:3747-56. 2005
    ..of interaction between junction organizing zona occludence protein 1 (ZO-1) and the tight junction protein occludin or the adherens junction protein alpha-catenin are unknown...
  21. ncbi Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions
    Raphaël Etournay
    INSERM UMRS 587, Unité de Génétique des Déficits Sensoriels, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    J Cell Sci 120:2838-50. 2007
    ....
  22. ncbi Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 310:140-51. 2005
    ..b>Occludin was the first integral membrane protein to be discovered, but it is not indispensable for the formation of TJ ..
  23. ncbi Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase
    Svetlana M Stamatovic
    Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Sci 116:4615-28. 2003
    ..of actin cytoskeleton (stress fiber formation) and redistribution of tight junction proteins, ZO-1, ZO-2 occludin and claudin-5, from the Triton X-100-soluble to the Triton X-100-insoluble fractions...
  24. ncbi Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine
    Hiroki Fujita
    Dept of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    J Histochem Cytochem 54:933-44. 2006
    ..This manuscript contains online supplemental material available at http://www.jhc.org. Please visit this article online to view these materials...
  25. ncbi The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4
    Zhengquan Yu
    Departments of Medicine and Biological Chemistry, University of California, Irvine, CA 92697 4030, USA
    Dev Biol 299:122-36. 2006
    ..These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation...
  26. ncbi Distinct subdomain organization and molecular composition of a tight junction with adherens junction features
    Fabio D Nunes
    Laboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 119:4819-27. 2006
    ....
  27. doi Dicer is required for Sertoli cell function and survival
    Gwang Jin Kim
    Institute of Human Genetics, University of Freiburg, Germany
    Int J Dev Biol 54:867-75. 2010
    ..Taken together, the results of this study show that Dicer is required for Sertoli cell function and survival and for spermatogenesis in mice...
  28. pmc Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier
    Linlin Su
    Center for Biomedical Research, Population Council, New York, NY 10065, USA
    Exp Cell Res 316:2945-60. 2010
    ..Testosterone and TGF-β3 also induced the association between internalized occludin (a BTB integral membrane protein) and clathrin, as well as early endosome antigen-1 (EEA-1)...
  29. pmc Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1054-64. 2011
    ..The expression of occludin is markedly decreased in intestinal permeability disorders, including in Crohn's disease, ulcerative colitis, and ..
  30. pmc Dynamic migration of γδ intraepithelial lymphocytes requires occludin
    Karen L Edelblum
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:7097-102. 2012
    ..As a result, each γδ IEL contacts multiple epithelial cells. Occludin is concentrated at sites of γδ IEL/epithelial interaction, where it forms a ring surrounding the γδ IEL...
  31. pmc Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition
    G Youssef
    Livingstone Skin Research Centre for Children, UCL Institute of Child Health, London WC1N 1EH, UK
    Dev Biol 380:274-85. 2013
    ..This was accompanied by a change of Claudin-1 localisation to the cell surface and interaction between Occludin and Claudin-1 which are thought to be required for tight junction formation...
  32. pmc Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5
    Sebastian Seidl
    The Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway
    PLoS ONE 8:e62756. 2013
    ..Thus, much effort has been made during the last decades to characterize the functions of aPKCs using gene targeting approaches and depletion studies. However, little is known about the specific roles of each isoform in mouse development...
  33. pmc beta-Catenin protects the epidermis from mechanical stresses
    Samriddha Ray
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 202:45-52. 2013
    ..These data demonstrate that a complete understanding of the functions of cell adhesion proteins must take into account their roles in response to mechanical stresses. ..
  34. pmc Crumbs3 is essential for proper epithelial development and viability
    Eileen L Whiteman
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Mol Cell Biol 34:43-56. 2014
    ..Taken together, our data indicate that Crumbs3 is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. ..
  35. doi Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering
    Zlatko Kopecki
    Centre for Regenerative Medicine, Mawson Institute, University of South Australia, Adelaide, Australia Women s and Children s Health Research Institute, Adelaide, Australia
    J Pathol 232:541-52. 2014
    ..These results therefore demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of EB patients...
  36. pmc Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis
    Oh oka Kyoko
    Department of Immunology, University of Yamanashi Faculty of Medicine, Yamanashi, Japan
    PLoS ONE 9:e98016. 2014
    ..Because intestinal permeability depends on tight junction (TJ) that regulates the epithelial paracellular pathway, this study investigated whether the circadian clock regulates the expression levels of TJ proteins in the intestine...
  37. pmc Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation
    Liwei Xie
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Mol Cell Biol 34:3013-23. 2014
    ..Hypoxic induction of CAV1 in the colon was essential for intestinal barrier integrity by regulating occludin expression...
  38. pmc Keratin 76 is required for tight junction function and maintenance of the skin barrier
    Tia DiTommaso
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    PLoS Genet 10:e1004706. 2014
    ....
  39. doi Redox Regulation of Cell Contacts by Tricellulin and Occludin: Redox-Sensitive Cysteine Sites in Tricellulin Regulate Both Tri- and Bicellular Junctions in Tissue Barriers as Shown in Hypoxia and Ischemia
    Jimmi Cording
    1 Leibniz Institut für Molekulare Pharmakologie, Berlin, Germany
    Antioxid Redox Signal 23:1035-49. 2015
    ..TJ-associated marvel proteins (TAMPs; tricellulin, occludin, marvelD3) are thought to be relevant to regulation...
  40. doi Elucidating pathways of Toxoplasma gondii invasion in the gastrointestinal tract: involvement of the tight junction protein occludin
    Caroline M Weight
    Gut Health and Food Safety Institute Strategic Programme, Norwich Research Park, Norwich, NR4 7UA, UK Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UA, UK
    Microbes Infect 17:698-709. 2015
    ..During invasion, T. gondii co-localized with occludin. Reducing the levels of endogenous cellular occludin with specific small interfering RNAs significantly reduced ..
  41. pmc Occludin S490 Phosphorylation Regulates Vascular Endothelial Growth Factor-Induced Retinal Neovascularization
    Xuwen Liu
    Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, Michigan
    Am J Pathol 186:2486-99. 2016
    b>Occludin is a transmembrane tight junction protein that contributes to diverse cellular functions, including control of barrier properties, cell migration, and proliferation...
  42. doi Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
    Isabelle Plante
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Biol Reprod 82:837-47. 2010
    ..localization of Cx26 (Gjb2), Cx30 (Gjb6), Cx32 (Gjb1), E-cadherin, P-cadherin, beta-catenin, claudin-1, and occludin were all unaffected by the decreased levels of Cx43 at parturition, suggesting no cross-talk to other connexins ..
  43. pmc Brain penetration of the OAB drug trospium chloride is not increased in aged mice
    Jasmin Kranz
    Institute of Pharmacology and Toxicology, Justus Liebig University of Giessen, Frankfurter Str 107, 35392, Giessen, Germany
    World J Urol 31:219-24. 2013
    ....
  44. doi The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    Jorge Ivan Alvarez
    Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Science 334:1727-31. 2011
    ..Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis...
  45. pmc Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys
    Abdul Soofi
    Dept of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 365:241-50. 2012
    ..These experiments provide new insight into the role of Pax2 protein levels in determining correct renal architecture and cell fate. These new Pax2 alleles are valuable genetic reagents for in vivo studies of urogenital development...
  46. pmc Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation
    Li Chin Yao
    Department of Anatomy, Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Am J Pathol 180:2561-75. 2012
    ..These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells...
  47. doi Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies
    Kozo Nakai
    Department of Dermatology, Faculty of Medicine, Kagawa University, Japan
    Am J Pathol 181:969-77. 2012
    ..Herein, we report the decreased expression of epidermal growth factor receptor (EGFR), E-cadherin, occludin, and SIRT1 in the skin of Flg(ft) mice, compared with those in C57BL/6J mice...
  48. doi The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2
    Su Ren Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Biol Reprod 88:56. 2013
    ..Compared with control testes, the expression of CAMs (such as E-cadherin, N-cadherin, claudin11, occludin, beta-catenin, and ZO-1) was not obviously altered in Wt1(-/flox); Amh-Cre testes...
  49. ncbi Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin
    M Ohsugi
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Dev Biol 185:261-71. 1997
    ..against alpha-, beta-, or gamma-(plakoglobin)-catenin and junctional and cytoskeletal proteins including ZO-1 and occludin (tight junctions), desmoglein1 (desmosomes), connexin43 (gap junctions), and EndoA (cytokeratin intermediate ..
  50. ncbi Tight junction proteins
    S Citi
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1448:1-11. 1998
  51. ncbi Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:5981-6. 1999
    ..Consistently, occludin as well as alpha catenin directly bound to N-ZO-2 as well as the NH2-terminal dlg-like portion of ZO-1 (N-ZO-1) ..
  52. ncbi Cellular immunolocalization of occludin during embryonic and postnatal development of the mouse testis and epididymis
    D G Cyr
    Centre de Recherche en Santé Humaine, Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Pointe Claire, Canada
    Endocrinology 140:3815-25. 1999
    ..In the present study, occludin, a constituent integral membrane protein of tight junctions, was localized by immunofluorescent confocal ..
  53. ncbi Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures
    J D Growney
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Genomics 64:62-81. 2000
    ..Several, but not all, of these Naip loci are contained within the Lgn1 critical interval. We present a model for the origins of the mouse and human repetitive arrays from a common ancestral haplotype...
  54. ncbi Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Mech Dev 97:93-104. 2000
    ..However, following assembly of the TJ transmembrane protein, occludin, from the early 32-cell stage when blastocoel formation begins, ZO-1alpha- and other TJ proteins (ZO-1alpha+ ..
  55. ncbi The murine gene, Traube, is essential for the growth of preimplantation embryos
    T Thomas
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Dev Biol 227:324-42. 2000
    ..This paucity of ribosomes together with the localization of TRB to the nucleoli, the site of ribosome synthesis, suggests that TRB is involved in the synthesis of ribosomes...
  56. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ....
  57. ncbi Protein kinase C regulates the phosphorylation and cellular localization of occludin
    A Y Andreeva
    Forschungsinstitut fur Molekulare Pharmakologie, 13125 Berlin Buch and Charité, Humboldt Universitat Berlin, 13092 Berlin, Germany
    J Biol Chem 276:38480-6. 2001
    b>Occludin is an integral membrane phosphoprotein specifically associated with tight junctions, contributing to the structure and function of this intercellular seal...
  58. ncbi Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, 85724, USA
    Dev Biol 251:206-20. 2002
    ..These results provide evidence of a critical role for endothelial gap junction-mediated communication in the development and/or functional maintenance of segments of the mouse vasculature...
  59. ncbi Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development
    F J Unda
    Departamento de Biologia Celular y Ciencias Morfologicas, Facultad de Medicina y Odontologia, Universidad del Pais Vasco Euskal Herriko Unibertsitatea, Leioa, Vizcaya, Spain
    Histol Histopathol 18:27-38. 2003
    ..we have studied the distribution pattern of the tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin in the developing mouse tooth as a model...
  60. ncbi Role of connexin37 and connexin40 in vascular development
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Cell Commun Adhes 10:379-85. 2003
    ..In addition, Cx37 and Cx40 appear to be mutually dependent on each other for normal expression in vascular endothelium...
  61. ncbi Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland
    Atsushi Hashizume
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    Dev Dyn 231:425-31. 2004
    ..These results will provide a valuable resource for further investigation of tubulogenesis and physiological regulation of claudin-based tight junctions...
  62. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  63. ncbi Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys
    Hiroshi Ohta
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 68:149-55. 2006
    ..chain reaction for the claudins examined, including claudins 1-4, 8, 10, 11, and 16, and the TJ proteins occludin and ZO-1...
  64. ncbi The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis
    Elisabeth Raschperger
    Ludwig Institute for Cancer Research, Nobels v 3, SE 171 77 Stockholm, Sweden
    Exp Cell Res 312:1566-80. 2006
    ..the body cavities in adult mice, where it specifically co-localizes with the tight junction components ZO-1 and occludin. Notably, CAR could not be detected in endothelial cells of the vasculature, including brain capillaries...
  65. pmc Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells
    Mito Kanatsu-Shinohara
    Department of Molecular Genetics, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan tshinoha2virus kyoto u ac jp
    Proc Natl Acad Sci U S A 103:8018-23. 2006
    ..Using this strategy, the efficiency of homologous recombination for the occludin gene locus was 1.7% using a nonisogenic DNA construct...
  66. ncbi Involvement of MAPKs in endostatin-mediated regulation of blood-retinal barrier function
    Matthew Campbell
    UCD School of Biomolecular Biomedical Sciences, Conway Institute, University College Dublin, Dublin, Ireland
    Curr Eye Res 31:1033-45. 2006
    ..Moreover, it was hypothesized that endostatin-induced occludin upregulation regulated VEGF165-mediated increases in endothelial cell permeability and involved activation of the ..
  67. ncbi Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 98:1027-34. 2007
    We have previously demonstrated that epigenetic silencing of occludin, a tight junction-associated membrane protein, results in the acquisition of apoptotic resistance to various apoptogenic stimuli, causally contributing to the enhanced ..
  68. ncbi Coxsackievirus and adenovirus receptor is up-regulated in migratory germ cells during passage of the blood-testis barrier
    Momina Mirza
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Institutet, Box 240, SE 17177, Stockholm, Sweden
    Endocrinology 148:5459-69. 2007
    ..Finally, an intermediate compartment occupied by CAR-positive, migrating germ cells and flanked by two occludin-containing junctions is identified...
  69. ncbi Production of knockout mice by gene targeting in multipotent germline stem cells
    Masanori Takehashi
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Dev Biol 312:344-52. 2007
    ..Spermatozoa that were deficient in the occludin gene could be recovered from animals that were chimeric with mGS cells that underwent homologous recombination...
  70. pmc Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells
    Masaru Yamamoto
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Am J Pathol 172:521-33. 2008
    ..Posttranslational modifications of essential endothelial TJ proteins, occludin and claudin-5, contribute and possibly disrupt BBB integrity...
  71. pmc ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
    Zhihui Zhong
    Center for Neurodegenerative and Vascular Brain Disorders and Department of Neurosurgery, University of Rochester Medical Center, Kornberg Medical Research Bldg, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Nat Neurosci 11:420-2. 2008
    ..disrupted the blood-spinal cord barrier in mice by reducing the levels of the tight junction proteins ZO-1, occludin and claudin-5 between endothelial cells...
  72. doi Cell-surface biotinylation to study endocytosis and recycling of occludin
    Noriyuki Nishimura
    Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Methods Mol Biol 440:89-96. 2008
    ..b>Occludin and claudins are distinct transmembrane proteins localized to the TJs...
  73. doi Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 327:301-12. 2009
    ..This study shows that testis cord differentiation is independent of Sox9, and that concerted Sox9 and Sox8 function in post E14.0 Sertoli cells is essential for the maintenance of testicular function...
  74. pmc Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    Richard Daneman
    Stanford University School of Medicine, Department of Developmental Biology, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:641-6. 2009
    ..Taken together these experiments reveal an essential role for Wnt/beta-catenin signaling in driving CNS-specific angiogenesis and provide molecular evidence that angiogenesis and BBB formation are in part linked...
  75. doi Myc regulates embryonic vascular permeability and remodeling
    Eniko Kokai
    Institute of Physiological Chemistry, Ulm University, Ulm, Germany
    Circ Res 104:1151-9. 2009
    ..Thus, the net outcome of an excess of vascular endothelial growth factor-A and angiopoietin-2 in the face of an elevated cellular turnover appears to be a defect in vascular integrity...
  76. pmc CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity
    Larissa Lozovatsky
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Biol Cell 20:4489-99. 2009
    ..Thus, CASK expression and the appropriate localization of DLG1 are not essential for either epithelial polarity or intestinal homeostasis in vivo...
  77. pmc Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure
    Feng Chen
    Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA
    Hepatology 50:1914-23. 2009
    ..Endogenous overexpression of MMP-9 in brain ECs resulted in significant degradation of the TJ proteins occludin and claudin-5...
  78. pmc Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor
    Preethi Vijayaraj
    Abteilung für Zellbiochemie, Institut für Biochemie und Molekularbiologie and 2 Bonner Forum Biomedizin, Universitat Bonn, 53115 Bonn, Germany
    J Cell Biol 187:175-84. 2009
    ..Our findings demonstrate a novel keratin function upstream of mTOR signaling via GLUT localization and have implications for pathomechanisms and therapy approaches for keratin disorders and the analysis of other gene families...
  79. pmc An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
    Magali Saint-Geniez
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:18751-6. 2009
    ..These changes are reminiscent of geographic atrophy (GA) and point to a role for RPE-derived VEGF in the maintenance of the choriocapillaris...
  80. pmc Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature
    Harold Kim
    Sunnybrook Research Institute University of Toronto 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada
    BMC Dev Biol 10:72. 2010
    ..While the in vitro data suggest that gene reprogramming occurs upon Prox1 expression, it is not clear if this is a direct result of Prox1 in vascular endothelial cells in vivo...
  81. doi Differential expression patterns of the tight junction-associated proteins occludin and claudins in secretory and mature ameloblasts in mouse incisor
    Masaki Hata
    Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8525, Japan
    Med Mol Morphol 43:102-6. 2010
    ..primarily as a barrier against paracellular transport between epithelial cells and are composed mainly of occludin (OLD) and claudins (CLDs). The CLD family consists of 24 members that show tissue- or cell-specific expression...
  82. pmc Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria
    Mary C O'Driscoll
    University of Manchester, Manchester Academic Health Science Centre, Central Manchester Foundation Trust University Hospitals, UK
    Am J Hum Genet 87:354-64. 2010
    ..The OCLN gene encodes occludin, an integral component of tight junctions...
  83. pmc Pericytes are required for blood-brain barrier integrity during embryogenesis
    Richard Daneman
    UCSF Department of Anatomy, 513 Parnassus Avenue, HSW1301, San Francisco, California 94143 0452, USA
    Nature 468:562-6. 2010
    ..These data indicate that pericyte-endothelial cell interactions are critical to regulate the BBB during development, and disruption of these interactions may lead to BBB dysfunction and neuroinflammation during CNS injury and disease...
  84. doi Cellular and subcellular localization of aquaporins 1, 3, 8, and 9 in amniotic membranes during pregnancy in mice
    Ken Kobayashi
    Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku ku, Tokyo, 160 8582, Japan
    Cell Tissue Res 342:307-16. 2010
    ....
  85. doi Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads
    Masatomo Kusaka
    Division for Sex Differentiation, Center for Transgenic Animals and Plants, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    Endocrinology 151:5893-904. 2010
    ..Our results strongly suggest that Emx2 is required for regulation of tight junction assembly and allowing migration of the gonadal epithelia to the mesenchyme, which are possibly mediated by suppression of Egfr expression...
  86. doi The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
    Max Werth
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 137:3835-45. 2010
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation...
  87. pmc Claudin-2 forms homodimers and is a component of a high molecular weight protein complex
    Christina M Van Itallie
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:3442-50. 2011
    ..identified a relatively discrete high molecular weight complex containing at least claudin-1, claudin-2, and occludin; the difference in the protein complex sizes between cultured cells and tissues may reflect differences in tight ..
  88. doi Expression of coxsackievirus and adenovirus receptor isoforms in developing mouse bladder uroepithelium
    Myung Chan Gye
    Department of Life Science, Hanyang University College of Natural Sciences, Seoul Korea
    Urology 77:1009.e9-1009.e18. 2011
    ..In the present study, we examined the developmental changes in the expression of coxsackievirus and adenovirus receptor (CAR) isoforms in mouse bladder uroepithelium...
  89. pmc Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles
    Sandra Ciesek
    Medizinische Hochschule Hannover, Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol 85:7613-21. 2011
    ..The tight junction component occludin (OCLN) is essential for HCV entry into host cells, and the differences between human and murine OCLN are thought ..
  90. pmc EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation
    Carla Danussi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, National Cancer Institute, 33081 Aviano, Italy
    J Cell Biol 195:131-45. 2011
    ..In addition, EMILIN1 is identified as a novel ligand for keratinocyte α9β1 integrin, suggesting prospective roles for this receptor-ligand pair in skin homeostasis...
  91. doi Rac mediates mouse spermatogonial stem cell homing to germline niches by regulating transmigration through the blood-testis barrier
    Seiji Takashima
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cell Stem Cell 9:463-75. 2011
    ..Short hairpin RNA (shRNA) -mediated suppression of claudin3, which was downregulated by Rac inhibition, reduced the SSC homing efficiency. Thus, Rac1 is a critical regulator of SSC homing and proliferation...
  92. ncbi Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
    E Parmantier
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Neuron 23:713-24. 1999
    ..They also show that Schwann cell-derived signals can act as important regulators of nerve development...
  93. pmc Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 147:185-94. 1999
    ..e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands...
  94. ncbi Post-translational control of occludin membrane assembly in mouse trophectoderm: a mechanism to regulate timing of tight junction biogenesis and blastocyst formation
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Development 127:831-40. 2000
    ..mechanisms regulating the timing of blastocyst formation, we have examined the dynamics of expression of occludin, an integral membrane protein of the TJ...
  95. pmc High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis
    J D Growney
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115, USA
    Genome Res 10:1158-71. 2000
    ..Our genetic map suggests the presence of two hotspots of recombination within the Naip array, indicating that the 3' portion of Naip may be involved in the genomic instability at this locus...
  96. ncbi Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Invest Dermatol 118:1073-9. 2002
    b>Occludin and claudins are tetraspan-transmembrane proteins in tight junctions. Maculae occludentes, which are less-developed tight junctions, occur in the granular cell layer of the epidermis...
  97. ncbi Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse
    Kyoji Takekuni
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 278:5497-500. 2003
    ..These results indicate that nectin-1 and -3 are involved in the localization of PAR-3 at AJs in the neuroepithelial cells of the embryonic telencephalon...
  98. pmc Identification of PKCzetaII: an endogenous inhibitor of cell polarity
    Scott J Parkinson
    Protein Phosphorylation Laboratory, Cancer Research UK, London Research Institute, London, UK
    EMBO J 23:77-88. 2004
    ..The data demonstrate a regulatory role for PKCzetaII in the maintenance of cell transformation and the development of cell polarity...
  99. ncbi Role of occludin, a tight junction protein, in blastocoel formation, and in the paracellular permeability and differentiation of trophectoderm in preimplantation mouse embryos
    Jinmee Kim
    Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133 791, Korea
    Mol Cells 17:248-54. 2004
    ..We examined the effect of occludin antibody on blastocoel formation, blastocyst permeability, and expression of H19 and Oct-4, markers of TE ..
  100. pmc Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier
    Heping Xu
    Department of Ophthalmology, School of Medicine, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 46:2487-94. 2005
    ..The mechanisms by which leukocytes transmigrate the blood-retina barrier (BRB) without affecting endothelial permeability are controversial...
  101. ncbi Abnormal development of urogenital organs in Dlgh1-deficient mice
    Akiko Iizuka-Kogo
    Department of Anatomy I, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Development 134:1799-807. 2007
    ..Our findings might contribute to a better understanding of such abnormalities...

Research Grants3

  1. REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENES
    Joyce Lloyd; Fiscal Year: 2003
    ..These results will predict the proteins involved in early beta-globin gene suppression. ..
  2. Role of KLF2 in erythropoiesis and globin expression
    Joyce A Lloyd; Fiscal Year: 2010
    ..Our long-term goal is to use KLF2 in strategies to increase embryonic/fetal beta-globin, to treat patients with beta-hemoglobinopathies. ..
  3. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..