Ntf3

Summary

Gene Symbol: Ntf3
Description: neurotrophin 3
Alias: AI316846, AI835689, HDNF, NGF-2, Nt3, Ntf-3, neurotrophin-3, nerve growth factor 2, neurotrophic factor
Species: mouse

Top Publications

  1. ncbi NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
    P C Maisonpierre
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Neuron 5:501-9. 1990
  2. ncbi Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
    P Ernfors
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 77:503-12. 1994
  3. ncbi Complementary roles of BDNF and NT-3 in vestibular and auditory development
    P Ernfors
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Neuron 14:1153-64. 1995
  4. pmc Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons
    L Tessarollo
    Molecular Embryology Section, Frederick Cancer Research and Development Center, MD 21702
    Proc Natl Acad Sci U S A 91:11844-8. 1994
  5. ncbi Role of neurotrophins in mouse neuronal development
    R Klein
    European Molecular Biology Laboratory, Differentiation Programme, Heidelberg, Germany
    FASEB J 8:738-44. 1994
  6. ncbi Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
    I Farinas
    Department of Physiology, University of California School of Medicine, San Francisco 94143 0724
    Nature 369:658-61. 1994
  7. ncbi Dependence of developing group Ia afferents on neurotrophin-3
    J Kucera
    Department of Neurology, Boston University Medical Center, Massachusetts 02118 2394, USA
    J Comp Neurol 363:307-20. 1995
  8. ncbi Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia
    F A White
    Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 16:4662-72. 1996
  9. ncbi Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation
    M S Airaksinen
    Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg Martinsried, Republic of Germany
    Neuron 16:287-95. 1996
  10. pmc Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors
    I Farinas
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:1065-78. 1996

Research Grants

Scientific Experts

Detail Information

Publications112 found, 100 shown here

  1. ncbi NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
    P C Maisonpierre
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Neuron 5:501-9. 1990
    To obtain insight into the site and stage specificity of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) action in vivo, we compared the expression patterns of the genes for these three ..
  2. ncbi Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
    P Ernfors
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 77:503-12. 1994
    ..Importantly, the number of muscle spindles in heterozygous mutant mice was half of that in control mice, indicating that NT-3 is present at limiting concentrations in the embryo...
  3. ncbi Complementary roles of BDNF and NT-3 in vestibular and auditory development
    P Ernfors
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Neuron 14:1153-64. 1995
    ..These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems...
  4. pmc Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons
    L Tessarollo
    Molecular Embryology Section, Frederick Cancer Research and Development Center, MD 21702
    Proc Natl Acad Sci U S A 91:11844-8. 1994
    b>Neurotrophin 3 (NT-3) is one of four related polypeptide growth factors that share structural and functional homology to nerve growth factor (NGF)...
  5. ncbi Role of neurotrophins in mouse neuronal development
    R Klein
    European Molecular Biology Laboratory, Differentiation Programme, Heidelberg, Germany
    FASEB J 8:738-44. 1994
    ..Mice deficient for brain-derived neurotrophic factor (BDNF) and its receptor, encoded by the trkB gene, display loss of sensory neurons responsive to tactile ..
  6. ncbi Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
    I Farinas
    Department of Physiology, University of California School of Medicine, San Francisco 94143 0724
    Nature 369:658-61. 1994
    ..16). In particular, neurotrophin-3 is essential for survival of sympathetic and sensory neurons that later become dependent on nerve growth factor or brain-derived neurotrophic factor.
  7. ncbi Dependence of developing group Ia afferents on neurotrophin-3
    J Kucera
    Department of Neurology, Boston University Medical Center, Massachusetts 02118 2394, USA
    J Comp Neurol 363:307-20. 1995
    ..Thus, developing Ia neurons may be dependent on NT-3 intrinsic to the DRGs before they reach a stage of potential dependence on NT-3 retrogradely derived from skeletal muscles or spinal motor neurons...
  8. ncbi Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia
    F A White
    Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 16:4662-72. 1996
    ..We suggest that the discrepancy in cell loss between NT-3(-/-) and trkC(-/-) mutants is attributable to the ability of NT-3 to support DRG neurons via TrkA in the artificial situation where TrkC is absent...
  9. ncbi Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation
    M S Airaksinen
    Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg Martinsried, Republic of Germany
    Neuron 16:287-95. 1996
    ..Thus, NT-3 is essential for the maintenance of specific cutaneous afferents known to subserve fine tactile discrimination in humans...
  10. pmc Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors
    I Farinas
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:1065-78. 1996
    ..Although deficits occur before final target innervation, we show that NT-3 is expressed at all stages in regions accessible to these neurons or their axons and is only restricted to final targets after innervation...
  11. ncbi Functional roles of neurotrophin 3 in the developing and mature sympathetic nervous system
    X F Zhou
    Department of Human Physiology, Flinders University of South Australia, Adelaide, Australia
    Mol Neurobiol 13:185-97. 1996
    ..Thus, in addition to its role in the differentiation of sympathetic neurons, NT3, like NGF, is also an effector tissue-derived neurotrophic factor for these neurons in maturity.
  12. ncbi Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system
    T Ringstedt
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Development 124:2603-13. 1997
    The role of neurotrophin-3 (NT3) during sensory neuron development was investigated in transgenic mice overexpressing NT3 under the control of the promoter and enhancer regions of the nestin gene, an intermediate filament gene widely ..
  13. pmc Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurosci 17:6213-25. 1997
    Essential functions of neurotrophin 3 (NT-3) in regulating afferent and efferent innervation of the cochlea have been characterized by comparison of normal and NT-3 mutant mice...
  14. ncbi Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR
    B T Fundin
    Department of Anatomy, Uppsala University, Sweden
    Dev Biol 190:94-116. 1997
    ..in mystacial pads from mice with homozygous null mutations for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), the three tyrosine kinase receptors (trkA, trkB, trkC)..
  15. ncbi Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Doktorsringen 12A, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurosci 17:8667-75. 1997
    The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4) are crucial target-derived factors controlling the survival of peripheral sensory neurons during the ..
  16. ncbi Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice
    D J Liebl
    Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
    J Neurosci 17:9113-21. 1997
    ..We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes...
  17. pmc Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
    L Tessarollo
    Neural Development Group, ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 94:14776-81. 1997
    ..The similarities in cardiac defects observed in the trkC and NT-3 null mutant mice indicate that the trkC receptor mediates most NT-3 effects on the cardiac neural crest...
  18. ncbi Neurotrophins support the development of diverse sensory axon morphologies
    S I Lentz
    Center for the Study of Nervous System Injury, Department of Neurology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 19:1038-48. 1999
    ..Furthermore, neurotrophins support the appearance of distinct axonal morphologies that characterize different sensory neuron subpopulations...
  19. ncbi Neurotrophin-3 is required for proper cerebellar development
    B Bates
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 2:115-7. 1999
  20. pmc Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC
    E J Huang
    Program in Neuroscience, Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723, USA
    Development 126:2191-203. 1999
    ..Therefore, our data provide evidence that NT-3 supports the survival of TrkA-, TrkB- and TrkC-expressing neurons in the trigeminal ganglion by activating directly each of these receptors in vivo...
  21. ncbi NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
    N Francis
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    Dev Biol 210:411-27. 1999
    ..blood vessels, including those along which sympathetic axons grow, suggesting it may act as a retrograde neurotrophic factor, similar to nerve growth factor...
  22. ncbi Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye
    J L Bennett
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    Invest Ophthalmol Vis Sci 40:2996-3005. 1999
    The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are hypothesized to play an important role in vertebrate eye development because of their patterned expression in the developing and adult neuroretina, ..
  23. ncbi Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons
    R O'CONNOR
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143, USA
    Neuron 24:165-78. 1999
    ..that Maxillary Factor activity is composed of two neurotrophins, neurotrophin-3 (NT-3) and Brain-Derived Neurotrophic Factor (BDNF), which are produced by both target epithelium and pathway mesenchyme and which are therefore more ..
  24. pmc NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development
    W Y Kim
    Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Development 128:417-26. 2001
    ....
  25. ncbi Postnatal regulation of limb proprioception by muscle-derived neurotrophin-3
    M D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Comp Neurol 432:244-58. 2001
    ..However, our results also show that NT-3 may be therapeutic for proprioceptive axons immediately after nerve injury by delaying axon degeneration...
  26. ncbi Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons
    A Chalazonitis
    Department of Anatomy and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 21:5620-36. 2001
    ..A neuropoietic cytokine (CNTF) interacted with NT-3 in vitro, and if applied sequentially, compensated for NT-3 withdrawal. These observations indicate that NT-3 is required for the normal development of the ENS...
  27. ncbi Reduction of NT-3 or TrkC results in fewer putative vagal mechanoreceptors in the mouse esophagus
    Marion Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Auton Neurosci 108:22-31. 2003
    ..This concurs with their proposed function as vagal mechanosensors crucial for reflex peristalsis...
  28. ncbi The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival
    Tetsushi Sadakata
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 24:43-52. 2004
    ..CAPS2 antibody from mouse cerebella contained significant amounts of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and chromogranin B but not marker proteins for synaptic vesicle synaptophysin and synaptotagmin...
  29. pmc NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea
    Lino Tessarollo
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21701, USA
    J Neurosci 24:2575-84. 2004
    ..Our data provide genetic evidence that neurotrophins in the ear exert both survival and axon guidance roles...
  30. ncbi A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling
    Rejji Kuruvilla
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 118:243-55. 2004
    ....
  31. ncbi Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear
    Konstantina Stankovic
    Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:8651-61. 2004
    ..Quantitative RT-PCR analysis of neurotrophic factor expression shows a specific downregulation in expression of neurotrophin-3 (NT3) in the transgenic cochleas ..
  32. pmc A chemoattractant role for NT-3 in proprioceptive axon guidance
    Bariş Genç
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, USA
    PLoS Biol 2:e403. 2004
    ..Our results show that survival factor NT-3 acts as a short-distance axon guidance molecule for muscle sensory afferents as they approach their proper targets...
  33. pmc Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo
    Anna Stenqvist
    Unit of Molecular Neurobiology, MBB, Karolinska Institutet, Stockholm, Sweden
    EMBO Rep 6:973-8. 2005
    ..is dispensable, whereas TrkC is required for the neuronal rescue by the NT 3 allele in the brain-derived neurotrophic factor- and NT 3-dependent cochleovestibular system...
  34. pmc A disorganized innervation of the inner ear persists in the absence of ErbB2
    Jacqueline K Morris
    Department of Biology and Geology, Baldwin Wallace College, Berea, OH 44017, USA
    Brain Res 1091:186-99. 2006
    ..Reduction of overshooting afferents may be enhanced by a reduction of the neurotrophin Ntf3 transcript to about 25% of wild type...
  35. pmc Prenatal exposure to elevated NT3 disrupts synaptic selectivity in the spinal cord
    Zhi Wang
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurosci 27:3686-94. 2007
    ..In this study, we report that embryonic overexpression of neurotrophin-3 (NT3) in muscles disrupts the development of these specific Ia-MN connections, using transgenic (mlc/NT3) mice that ..
  36. ncbi Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors
    Sabrina L McIlwrath
    Department of Neurobiology, School of Medicine, University of Pittsburgh, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Eur J Neurosci 26:1801-12. 2007
    Constitutive overexpression of neurotrophin-3 (NT3) in murine skin results in an increased number of sensory neurons within the dorsal root ganglia, an increase of myelinated axons in cutaneous nerves, hyperinnervation of the skin, and ..
  37. doi Interactive roles of fibroblast growth factor 2 and neurotrophin 3 in the sequence of migration, process outgrowth, and axonal differentiation of mouse cochlear ganglion cells
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    J Neurosci Res 86:2376-91. 2008
    ..We used immunohistochemistry to locate neurotrophin 3 (NT3) and its high-affinity receptor (TrkC) in the auditory system, along with FGF2 and its R1 receptor, at ..
  38. pmc Regulation of neonatal development of retinal ganglion cell dendrites by neurotrophin-3 overexpression
    Xiaorong Liu
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Comp Neurol 514:449-58. 2009
    ..Recently, brain-derived neurotrophic factor (BDNF) has been shown to regulate this laminar refinement, and to enhance the development of dendritic ..
  39. pmc Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract
    Edward A Fox
    Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
    Cell Tissue Res 340:267-86. 2010
    ....
  40. doi Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10
    Ingrid Breuskin
    GIGA Neurosciences, University of Liege, Liege, Belgium
    J Neurochem 114:1827-39. 2010
    ..Moreover, brain-derived neurotrophic factor expression is increased in the hair cells of Sox10-deficient mice, a compensatory mechanism that may ..
  41. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
    ..This pattern of innervation by sensory neurons is maintained at least until P14, but fibers target the few Myo7a positive cells found in later stages...
  42. pmc Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons
    Jacob Tauris
    Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Eur J Neurosci 33:622-31. 2011
    ..The NTs brain-derived nerve growth factor (BDNF) and NT3 provide essential trophic support to auditory neurons...
  43. pmc Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation
    K M Albers
    Department of Pathology, University of Kentucky Medical Center, Lexington 40536, USA
    J Cell Biol 134:487-97. 1996
    ..These results indicate that in vivo overexpression of NT-3 by the epidermis enhances the number of sensory and sympathetic neurons and the development of selected sensory endings of the skin...
  44. pmc Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression
    I Farinas
    Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0724, USA
    J Neurosci 21:6170-80. 2001
    ..development of the deficit in the NT-3 mutant to the spatial-temporal expression patterns of brain-derived neurotrophic factor (BDNF) and NT-3, using lacZ reporters in each gene and with expression of the specific neurotrophin ..
  45. ncbi Excess target-derived neurotrophin-3 alters the segmental innervation of the skin
    A M Ritter
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA
    Eur J Neurosci 14:411-8. 2001
    ..boundaries were mapped in adult mice, it was found that those in nerve growth factor and brain-derived neurotrophic factor overexpressers were indistinguishable from wild-type animals but that overlap between adjacent segments was ..
  46. ncbi Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons
    Hsiao Huei Chen
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:3512-9. 2002
    ..Muscle spindles in Egr3-/- mice do not express NT3. Intramuscular injections of NT3 to Egr3-/- mice during the postnatal period restored sensory-motor connections...
  47. ncbi Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents
    Tushar D Patel
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 38:403-16. 2003
    To study the role of NT3 in directing axonal projections of proprioceptive dorsal root ganglion (DRG) neurons, NT3(-/-) mice were crossed with mice carrying a targeted deletion of the proapoptotic gene Bax...
  48. ncbi NT3 expressed in skin causes enhancement of SA1 sensory neurons that leads to postnatal enhancement of Merkel cells
    Robin F Krimm
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Comp Neurol 471:352-60. 2004
    To determine the role of NT3 in the postnatal maturation of Merkel cell (MC) sensory neurite complexes (touch domes), we examined the development of their neural and end-organ components in wild-type and transgenic mice that overexpress ..
  49. ncbi Neurotrophin-3 regulates mast cell functions in neonatal mouse skin
    Martin Metz
    Department of Dermatology, University Hospital Mainz, Mainz, Germany
    Exp Dermatol 13:273-81. 2004
    ..Our data suggest a role for NT-3 in the maturation of MCs, such as a TrkC-mediated stimulation of the differentiation of pre-existing, less mature MCs and/or by enhancing the migration of circulating MC precursors into the skin...
  50. ncbi Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3
    D E Wright
    Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 19:503-17. 1997
    ..The level of NT-3 in developing muscles may be the principal factor determining the number of proprioceptive neurons in dorsal root ganglions and spindles in skeletal muscles of adults...
  51. ncbi Formation of supernumerary muscle spindles at the expense of Golgi tendon organs in ER81-deficient mice
    J Kucera
    Department of Neurology, Boston University, 80 East Concord Street, Boston, MA 02118, USA
    Dev Dyn 223:389-401. 2002
    ..Segmental differences in muscle spindle and GTO dependence on ER81 suggest that more than one ETS transcription factor may participate in the regulation of limb proprioceptive system assembly in the mouse...
  52. ncbi The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
    D Soppet
    Molecular Embryology Section, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Cell 65:895-903. 1991
    ..Thus, the trk family of receptors are likely to be important signal transducers of NGF-related trophic signals in the formation and maintenance of neuronal circuits...
  53. ncbi BDNF is required for the normal development of taste neurons in vivo
    C Zhang
    Department of Biology, University of Michigan, Ann Arbor, 48109 1048, USA
    Neuroreport 8:1013-7. 1997
    ..mice corresponding to the three neurotrophin ligands for tyrosine kinase receptor B (TrkB): brain-derived neurotrophic factor (BDNF), neurotrophin (NT)3, NT4...
  54. ncbi Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:7326-36. 2003
    The temporally specific nature of neurotrophic factor-induced responses is a general feature of mammalian nervous system development, the mechanisms of which remain to be elucidated...
  55. ncbi Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis
    Geraldine Liot
    Universite de Caen, CNRS UMR 6551, Centre Cyceron, IFR 47, 14074 Caen Cedex, France
    Exp Neurol 187:38-46. 2004
    ..Altogether, our data demonstrate that NT-3 displayed an anti-apoptotic effect on cultured cortical neurons through a mechanism involving the recruitment of the PI-3 kinase/Akt signaling pathway...
  56. ncbi Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells
    Adele G Woolley
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Glia 56:306-17. 2008
    ..Finally, we observed significant reduction in width of the Schwann cell periaxonal collar in NT-3 mutant animals suggesting that loss of NT-3 and resulting reduction in MAG levels may alter signaling at the axon-glial interface...
  57. pmc Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice
    Ashley L Stewart
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Australia
    BMC Dev Biol 8:73. 2008
    ....
  58. pmc Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets
    Joriene C de Nooij
    Department of Neuroscience, Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA
    Neuron 77:1055-68. 2013
    ..The level of NT3 expression in individual muscles correlates with Etv1-dependence and the loss of pSNs triggered by Etv1 ..
  59. pmc The cellular and molecular basis of direction selectivity of Aδ-LTMRs
    Michael Rutlin
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 159:1640-51. 2014
    ..The neurotrophic factor BDNF is synthesized in epithelial cells on the caudal, but not rostral, side of hair follicles, in close ..
  60. ncbi Conserved linkage of neurotrophin-3 and von Willebrand factor on mouse chromosome 6
    L L Barrow
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618
    Mamm Genome 4:343-5. 1993
  61. ncbi Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development
    M J Donovan
    Department of Pathology, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 14:210-3. 1996
    b>Neurotrophin 3 (Nt3) is one of five neurotrophin growth factors which shape the development of the nervous system by regulating neuronal survival and differentiation...
  62. ncbi Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine
    M Reeben
    Department of Neurology, University of Kuopio, Finland
    J Neurosci Res 45:542-8. 1996
    ..Northern blot analysis indicated that mRNA levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) were significantly elevated about 1...
  63. ncbi Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR
    F L Rice
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Dev Biol 198:57-81. 1998
    ..newborn to 4-week-old mice that had homozygous functional deletions of the genes for NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), tyrosine kinase (trk) A, trkB, trkC, or p75...
  64. ncbi TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections
    A Martinez
    Department of Animal and Plant Cell Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7336-50. 1998
    ..The data also suggest that the genes encoding for synaptic proteins may be targets of TrkB and TrkC signaling pathways...
  65. ncbi Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Neuron 21:1003-15. 1998
    ..Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3...
  66. ncbi Brain-derived neurotrophic factor levels in the nervous system of wild-type and neurotrophin gene mutant mice
    R Kolbeck
    Max Planck Institute of Neurobiology, Martinsried, Germany
    J Neurochem 72:1930-8. 1999
    Although brain-derived neurotrophic factor is the most abundant and widely distributed neurotrophin in the nervous system, reproducible determinations of its levels have been hampered by difficulties in raising suitable monoclonal ..
  67. ncbi Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells
    M A Kahn
    Department of Neurobiology, UCLA School of Medicine, USA
    Glia 26:153-65. 1999
    ..These data will support an in vivo NT-3-dependent mechanism for the normal development of CNS glial cells...
  68. pmc Neuronal NT-3 is not required for synaptic transmission or long-term potentiation in area CA1 of the adult rat hippocampus
    L Ma
    University of Texas, Southwestern Medical Center, Center for Developmental Biology, Dallas 75235 9133, USA
    Learn Mem 6:267-75. 1999
    ..These results suggest that neuronal NT-3 does not play an essential role in normal synaptic transmission and some forms of plasticity in the mouse hippocampus...
  69. pmc Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo
    K M Giehl
    University of Saarland, Department of Anatomy, 66421 Homburg Saar, Germany
    J Neurosci 21:3492-502. 2001
    ..The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) promote neuronal survival via tyrosine kinase (Trk) receptors, whereas ..
  70. ncbi Muscle-derived neurotrophin-3 reduces injury-induced proprioceptive degeneration in neonatal mice
    D E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurobiol 50:198-208. 2002
    ..Our results demonstrate that in addition to its early actions on sensory neuron generation and naturally occurring cell death, NT-3 has important neuroprotective effects on muscle afferents during postnatal development...
  71. pmc Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC
    Katharine M Cronk
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Development 129:3739-50. 2002
    ..at least one kinase-lacking trkC isoform is transiently expressed on all the follicle cells, while neurotrophin 3 is transiently expressed only in the cells at the middle third of the follicle where the Merkel endings and ..
  72. ncbi FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
  73. ncbi BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development
    Karin Agerman
    Unit of Molecular Neurobiology, MBB, Karolinska Institutet, 171 77 Stockholm, Sweden
    Development 130:1479-91. 2003
    ..However, despite overlapping expression of TrkB and TrkC in many sensory ganglia, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) null mutant mice display selective losses in neuronal subpopulations...
  74. ncbi Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy)
    Kenzo Uchida
    Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Shimoaizuki 23, Matsuoka, 910 1193 Fukui, Japan
    Acta Neuropathol 106:29-36. 2003
    ..and immunoblot analyses were performed for the expression levels of endogenous brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, and their receptors, trkB and trkC in 24 tip-toe walking Yoshimura mice (twy/..
  75. ncbi Neurotrophin-3 signaling in mammalian Merkel cell development
    Viktor Szeder
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 228:623-9. 2003
    ..These results show that NT-3 signaling is not required for the differentiation of Merkel cells, but that it is essential for their postnatal survival...
  76. ncbi Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium
    P Jeanette Simpson
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 24:858-74. 2003
    ..These effects of NT-3 serve to maintain homeostasis between neuronal populations within the olfactory epithelium...
  77. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
  78. ncbi Support of trigeminal sensory neurons by nonneuronal p75 neurotrophin receptors
    Lixin Fan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 3124 Natural Science Building, 830 N University Ave, Ann Arbor, MI 48109 1048, USA
    Brain Res Dev Brain Res 150:23-39. 2004
    ....
  79. ncbi Pacinian corpuscle development involves multiple Trk signaling pathways
    J Sedy
    Institute of Anatomy, Charles University, First Faculty of Medicine, U nemocnice 3, 128 00 Prague, Czech Republic
    Dev Dyn 231:551-63. 2004
    ..Pacinian corpuscles was explored in neonatal mutant mice lacking nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) or neurotrophin-4 (NT4), or their cognate Trk receptors...
  80. ncbi Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development
    Rick A Friedman
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, CA 90057, USA
    Mech Dev 122:625-34. 2005
    ..We discuss a potential mechanism for the absence of neural precursors in the Eya1-/- inner ears and the primary and secondary mechanisms for the loss of cochleovestibular ganglion cells in the Eya1bor/bor hypomorphic mutant...
  81. ncbi Neurotrophin-3 null mutant mice display a postnatal motor neuropathy
    Adele G Woolley
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Eur J Neurosci 21:2100-10. 2005
    ..We discuss whether the neural degeneration is secondary to the disturbance of Schwann cell function, or due directly to a loss of neurotrophin-3 based support of the motoneuron...
  82. ncbi The role of neurotrophins in the maintenance of the spinal cord motor neurons and the dorsal root ganglia proprioceptive sensory neurons
    Heather E Stephens
    Dalhousie University, Department of Anatomy and Neurobiology, 5850 College Street, Halifax, NS, Canada B3H 5X1
    Int J Dev Neurosci 23:613-20. 2005
    ....
  83. ncbi Lingual deficits in neurotrophin double knockout mice
    Irina V Nosrat
    Laboratory of Oral Neurobiology, Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    J Neurocytol 33:607-15. 2004
    Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae...
  84. ncbi The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis
    Hui Li Li
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience PKU, Ministry of Education and Department of Neurobiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    FEBS Lett 580:1723-8. 2006
    ..Thus maintenance of high NDAP levels may cause apoptosis. The different regulations of NDAP expression by neurotrophins indicate that the expression of NDAP might be a checkpoint for apoptosis during neuronal development...
  85. pmc Sox2 is required for development of taste bud sensory cells
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 20:2654-9. 2006
    ....
  86. ncbi Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation
    Chun Hong Qiu
    Department of Integrative Physiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 148:1745-53. 2007
    ....
  87. doi The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
    Glial cell line-derived neurotrophic factor (GDNF) regulates multiple aspects of spinal motoneuron (MN) development, including gene expression, target selection, survival, and synapse elimination, and mice lacking either GDNF or its ..
  88. pmc Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn
    G Pollonini
    Department of Neuroscience, Box 1065, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 156:99-106. 2008
    ..These results suggest that a dysregulation in the expression of neurotrophins as well as proteins involved in synaptic development and plasticity may play a potential role in the neural pathology of DS in humans...
  89. doi Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    J Comp Neurol 511:92-108. 2008
    ..The expression of Kirrel3 was observed in TrkC-positive nerve fibers around neurotrophin 3 (NT3)-positive intrafusal muscle fibers of muscle spindles at E17.5...
  90. pmc Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations
    Matthew M Lavail
    Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Comp Neurol 511:724-35. 2008
    ..Thus, specificity of the neuroprotective effect of NT-3 is clearly demonstrated, and different molecular mechanisms are inferred to mediate the protective effect in light-induced and inherited RDs...
  91. pmc Non-centered spike-triggered covariance analysis reveals neurotrophin-3 as a developmental regulator of receptive field properties of ON-OFF retinal ganglion cells
    Donald R Cantrell
    Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois, USA
    PLoS Comput Biol 6:e1000967. 2010
    ..In summary, our study introduces STC-NC analysis which successfully identifies subtype RGCs and demonstrates how RF development relates to a neurotrophic driver in the retina...
  92. pmc Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats
    Michiko Hamatake
    Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480 0392, Japan
    J Biol Chem 286:21478-87. 2011
    In adult rat brains, brain-derived neurotrophic factor (BDNF) rhythmically oscillates according to the light-dark cycle and exhibits unique functions in particular brain regions. However, little is known of this subject in juvenile rats...
  93. doi Partial rescue of NT-3 null mutant phenotype by a PDGF-β regulated transgene
    Jarosław J Barski
    Center for Experimental Medicine, Medical University of Silesia, ul Medyków 4, 40 752 Katowice, Poland
    Neurosci Lett 501:179-84. 2011
    ..Mice carrying one or two PDGF-NT3 transgenes on a background null for wildtype NT-3 were generated by crossing with an NT-3 null strain...
  94. ncbi SCNN1, an epithelial cell sodium channel gene in the conserved linkage group on mouse chromosome 6 and human chromosome 12
    M H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618
    Genomics 24:185-6. 1994
    ..The observed order of mouse genes was centromere-Raf1-(2.1 +/- 2.1)-Scnn1, Vwf-(1.9 +/- 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf...
  95. ncbi Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses
    M Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    J Neurosci 18:8730-9. 1998
    ..Because NT-3 expression is reduced after focal seizures, impaired short-term facilitation may represent a protective response that limits the propagation of epileptiform activity from the entorhinal cortex to the hippocampus...
  96. ncbi Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    Lab Invest 79:557-72. 1999
    ..However, it is as yet unknown whether other members of the NGF family of neurotrophins, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), also modulate keratinocyte proliferation in situ...
  97. pmc Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice
    D J Liebl
    Center for Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9133, USA
    Proc Natl Acad Sci U S A 97:2297-302. 2000
    ..of neurons that differentiate primarily into proprioceptors whereas nerve growth factor and brain-derived neurotrophic factor (BDNF) support subpopulations that transmit nociception and mechanoreception, respectively...
  98. ncbi Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrus
    F Asztely
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    Eur J Neurosci 12:662-9. 2000
    ..Our data suggest that BDNF and NT-3 differentially regulate the synaptic impact of different afferent inputs onto single target neurons in the CNS...
  99. ncbi Formation of a full complement of cranial proprioceptors requires multiple neurotrophins
    G Fan
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, USA
    Dev Dyn 218:359-70. 2000
    ..cranial proprioceptive neurons of the trigeminal mesencephalic nucleus (TMN) require NT3, brain-derived neurotrophic factor (BDNF) or neurotrophin-4 (NT4) for their development...
  100. ncbi Expression of neurotrophins and their receptors in peripheral lung cells of mice
    Shiori Hikawa
    Department of Medicine, Kitasato University School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa 228 8555, Japan
    Histochem Cell Biol 118:51-8. 2002
    ..Recent reports indicated that neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5)] have numerous effects on non-neural cells, ..
  101. ncbi Distribution of neurotrophin receptors in the mouse neuromuscular system
    Philip W Sheard
    Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Int J Dev Biol 46:569-75. 2002
    ..We believe this result indicates that the neurotrophic relationship between alpha motoneurons and their target cells is not a simple one of neurotrophin supply by skeletal muscle cells and its uptake at the neuromuscular junction...

Research Grants9

  1. NEUROTROPHIN 3 IN NEURONAL INJURY AND DISEASE
    Douglas Wright; Fiscal Year: 2002
    ..Results from these studies will define new biological actions of NT-3 and reveal how manipulation of the trophic support of neurons may be useful to treat pathologic neural conditions. ..
  2. NEUROTROPHINS IN NEURONAL SURVIVAL AND DIFFERENTIATION
    Xin Liu; Fiscal Year: 2004
    ..are a four-member family of structurally related proteins; Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4)...
  3. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
  4. Regulatory Molecules in Enteric Nervous System
    ALCMENE CHALAZONITIS; Fiscal Year: 2006
    ....
  5. Antigen Identification in Occult Chorioretinopathies
    Jeffrey Bennett; Fiscal Year: 2006
    ....
  6. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
    ..that innervate the gastrointestinal (Gl) tract in mice with a mutation in either the brain-derived neurotrophic factor (BDNF) gene or the neurotrophin-3 (NT-3) gene...
  8. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  9. DEVELOPMENT OF EFFERENT NERVE FIBERS IN THE COCHLEA
    HANNA SOBKOWICZ; Fiscal Year: 2001
    ..plans to identify ultrastructurally the morphological and immunochemical character of vesiculated endings that express GAP-43 in the inner spiral bundle, the only neuronal pathway that contains this growth protein in the adult cochlea. ..