Nr4a2

Summary

Gene Symbol: Nr4a2
Description: nuclear receptor subfamily 4, group A, member 2
Alias: HZF-3, NOT, Nurr1, RNR-1, TINOR, TINUR, nuclear receptor subfamily 4 group A member 2, NUR-related factor 1, nur related protein 1, orphan nuclear receptor NURR1
Species: mouse

Top Publications

  1. doi Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
    Banafsheh Kadkhodaei
    Ludwig Institute for Cancer Research, Stockholm Branch, SE 171 77 Stockholm, Sweden
    J Neurosci 29:15923-32. 2009
  2. pmc A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
    Feng Qiu
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 28:3392-403. 2008
  3. pmc 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth
    Teruo Inamoto
    Department of Urology, The University of Texas M D Anderson Cancer Center, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:3825-33. 2008
  4. pmc Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons
    Olga Baron
    Institute of Neuroanatomy, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 287:19827-40. 2012
  5. pmc The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
    Tiia Ponnio
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:935-45. 2002
  6. ncbi The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation
    Kwang Hoon Song
    Hormone Research Center, Chungnam National University, Gwangju 500 757, Republic of Korea
    Mol Endocrinol 18:1929-40. 2004
  7. ncbi Identification of a new brain-specific transcription factor, NURR1
    S W Law
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Mol Endocrinol 6:2129-35. 1992
  8. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
  9. pmc Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    O Saucedo-Cardenas
    Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:4013-8. 1998
  10. ncbi Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
    S O Castillo
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
    Mol Cell Neurosci 11:36-46. 1998

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. doi Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
    Banafsheh Kadkhodaei
    Ludwig Institute for Cancer Research, Stockholm Branch, SE 171 77 Stockholm, Sweden
    J Neurosci 29:15923-32. 2009
    ..b>Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but ..
  2. pmc A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
    Feng Qiu
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 28:3392-403. 2008
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard ..
  3. pmc 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth
    Teruo Inamoto
    Department of Urology, The University of Texas M D Anderson Cancer Center, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:3825-33. 2008
    b>Nurr1 is an orphan nuclear receptor and a member of the nerve growth factor I-B subfamily of transcription factors with no known endogenous ligand or stimulator...
  4. pmc Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons
    Olga Baron
    Institute of Neuroanatomy, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 287:19827-40. 2012
    ..in mice deficient for Nurr1 or expressing the dominant-negative FGF receptor (FGFR) identified orphan nuclear receptor Nurr1 and FGFR1 as essential factors in development of mesencephalic dopaminergic (mDA) neurons...
  5. pmc The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
    Tiia Ponnio
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:935-45. 2002
    ..The precise role of Nor-1 in mammalian development has not been established...
  6. ncbi The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation
    Kwang Hoon Song
    Hormone Research Center, Chungnam National University, Gwangju 500 757, Republic of Korea
    Mol Endocrinol 18:1929-40. 2004
    ..These results suggest that DAX-1 acts as a novel coregulator of the orphan nuclear receptor Nur77, and that the DAX-1 may play a key role in the regulation of Nur77-mediated steroidogenesis in testicular Leydig cells...
  7. ncbi Identification of a new brain-specific transcription factor, NURR1
    S W Law
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Mol Endocrinol 6:2129-35. 1992
    ..to an additional family member and immediate early gene product, Nur77, and the novel factor is referred to as Nurr1 (Nur-related factor 1)...
  8. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
    ..The orphan nuclear receptor Nurr1 was shown to be expressed in developing dopamine neurons before the appearance of known phenotypic ..
  9. pmc Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    O Saucedo-Cardenas
    Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:4013-8. 1998
    b>Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing and mature dopaminergic neurons...
  10. ncbi Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
    S O Castillo
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
    Mol Cell Neurosci 11:36-46. 1998
    To ascertain the function of an orphan nuclear receptor Nurr1, a transcription factor belonging to a large gene family that includes receptors for steroids, retinoids, and thyroid hormone, we generated Nurr1-null mice by homologous ..
  11. ncbi Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice
    W Le
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
    Exp Neurol 159:451-8. 1999
    b>Nurr1, a member of the nuclear receptor superfamily of transcription factors, has been found to be essential for the development of ventral midbrain dopamine (DA)ergic neurons...
  12. pmc Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation
    M Maira
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    Mol Cell Biol 19:7549-57. 1999
    ..The Nur77 subfamily also includes two related receptors, Nur-related factor 1 (Nurr1) and neuron-derived orphan receptor 1 (NOR-1)...
  13. ncbi Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury
    W Le
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 73:2218-21. 1999
    Mutation in the Nurr1 gene, a member of the nuclear receptor superfamily, causes selective agenesis of dopaminergic neurons in the midbrain of null mice...
  14. ncbi Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
    A Wallen
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, S 171 77, Sweden
    Exp Cell Res 253:737-46. 1999
    The orphan nuclear receptor NURR1 was previously demonstrated to be required for the generation of mesencephalic dopamine (DA) cells...
  15. ncbi A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    M P Smidt
    Section of Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Neurosci 3:337-41. 2000
    ..disruption of this cascade did not block induction of tyrosine hydroxylase (TH), a key enzyme in DA synthesis, or Nurr1, a nuclear hormone receptor, Lmx1b knockout mice failed to induce the mesDA-specific homeodomain gene Ptx3 in TH-..
  16. ncbi Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem
    A Wallén A
    Ludwig Institute for Cancer Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Neurosci 18:649-63. 2001
    The orphan nuclear receptor Nurr1 is essential for development of midbrain dopamine (DA) cells...
  17. ncbi Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors
    Paola Sacchetti
    INSERM Unité 459, faculté de médecine Henri Warembourg, 1 place de Verdun, Lille 59045, France
    J Biol Chem 277:35088-96. 2002
    The nuclear receptor nurr1 is a transcription factor involved in the development and maintenance of neurons synthesizing the neurotransmitter dopamine...
  18. ncbi Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity
    J B Eells
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Dr, MSC 1766, Bethesda, MD 20892 1766, USA
    Behav Brain Res 136:267-75. 2002
    b>Nurr1, an orphan nuclear receptor, is essential for the differentiation of the midbrain dopamine (DA) neurons; however, its function in adult midbrain DA neurons has not been determined...
  19. ncbi Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
    Elisabet Hermanson
    Ludwig Institute for Cancer Research, Stockholm Branch, P O Box 240, S 171 77 Stockholm, Sweden
    Exp Cell Res 288:324-34. 2003
    b>Nurr1, a transcription factor belonging to the nuclear receptor family, is essential for the generation of midbrain dopamine (DA) cells during embryonic development...
  20. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..Wnt-3a promoted the proliferation of precursor cells expressing the orphan nuclear receptor-related factor 1 (Nurr1) but did not increase the number of tyrosine hydroxylase-positive neurons...
  21. ncbi Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 18:1731-8. 2003
    ..b>Nurr1, a member of the nuclear hormone receptor superfamily of transcription factors, is essential for establishing the ..
  22. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..Owing to the developmental failure of mesDA neurons in the lateral field of the midbrain, mesDA neurons are not found in the SNc and the projections to the caudate putamen are selectively lost...
  23. pmc Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation
    Kai Christian Sonntag
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Eur J Neurosci 19:1141-52. 2004
    The nuclear transcription factor Nurr1 is involved in the development and maintenance of the midbrain dopaminergic (DA) neuronal phenotype...
  24. ncbi Age-dependent dopaminergic dysfunction in Nurr1 knockout mice
    Chuantao Jiang
    Parkinson Disease Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Neurol 191:154-62. 2005
    The Nurr1 gene, which codes for a transcriptional factor in the nuclear receptor superfamily, plays an important role in the development of the mesencephalic dopaminergic (DAergic) system...
  25. ncbi The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
    J Jankovic
    Department of Neurology, Parkinson Disease Research Lab, Baylor College of Medicine, Houston, TX 77030, USA
    Prog Neurobiol 77:128-38. 2005
    b>Nurr1, a transcription factor belonging to the orphan nuclear receptor superfamily, is critical in the development and maintenance of the dopaminergic system and as such it may have role in the pathogenesis of Parkinson' disease (PD)...
  26. ncbi A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
    Nilima Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich Neuherberg, Germany
    Development 133:89-98. 2006
    ..They also suggest the Wnt1-controlled signaling pathway as a promising target for new therapeutic strategies in the treatment of Parkinson's disease...
  27. ncbi Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
    E Andersson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Sweden
    Development 133:507-16. 2006
    ..that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors...
  28. ncbi Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
    Julianna Kele
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institutet, Retzius building A1, Stockholm, Sweden
    Development 133:495-505. 2006
    ..Our results demonstrate that Ngn2 is required for the differentiation of Sox2(+) ventricular zone progenitors into Nurr1(+) postmitotic dopaminergic neuron precursors in the intermediate zone, and that it is also likely to be required ..
  29. pmc Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
    Cecile Martinat
    Department of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:2874-9. 2006
    ..development of midbrain DA neurons by expression analyses and loss-of-function knockout mouse studies, including Nurr1, Pitx3, Lmx1b, Engrailed-1, and Engrailed-2...
  30. ncbi Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem
    Elisabet Hermanson
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
    J Neurochem 97:1403-11. 2006
    The orphan nuclear receptor Nurr1 is expressed in the developing and adult central nervous system. Previous studies have shown that Nurr1 is essential for the generation of midbrain dopamine neurons...
  31. ncbi Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus
    Jordi Guimera
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, 35 8006, Ingolstädter Landstrasse, 1, Neuherberg, Germany
    Development 133:3847-57. 2006
    ..Other brain regions, as well as other neural systems, are not affected...
  32. ncbi VIP is a transcriptional target of Nurr1 in dopaminergic cells
    Yu Luo
    Dept of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14624, USA
    Exp Neurol 203:221-32. 2007
    The orphan nuclear receptor Nurr1 is required for the development of the ventral mesencephalic dopaminergic neurons. These are the same neurons that are invariantly lost in patients with Parkinson's disease...
  33. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007
    ..a potent trophic factor for midbrain dopamine (DA) neurons, but its in vivo function and signaling mechanisms are not entirely understood...
  34. ncbi Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice
    Chao Guo
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Development 134:317-25. 2007
    ..By contrast, Otx2 and Pax6 expression was not affected in Lmx1b-/- embryos...
  35. ncbi Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells
    Elin K I Andersson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S 221 84 Lund, Sweden
    Exp Cell Res 313:1172-80. 2007
    ..We over-expressed Ngn2 and Nurr1, two genes present in the ventral midbrain and important for normal development of mesDA neurons, in multi-..
  36. ncbi Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
    Anna L M Ferri
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:2761-9. 2007
    ..Subsequently, Foxa1 and Foxa2 regulate the expression of Nurr1 (Nr4a2) and engrailed 1 in immature neurons and the expression of aromatic l-amino acid decarboxylase and tyrosine ..
  37. ncbi Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells
    Yuichi Ono
    KAN Research Institute Inc, KobeMI R and D Center 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Development 134:3213-25. 2007
    ..the factors that regulate mesDA neuron development, the mechanisms underlying mesDA neuron specification are not fully understood...
  38. doi Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro
    Chang Hwan Park
    Department of Microbiology, College of Medicine, Hanyang University, Sungdong gu, Seoul, Republic of Korea
    FEBS Lett 582:537-42. 2008
    Roles of Nurr1 and neurogenin 2 (Ngn2) have been shown in midbrain dopamine (DA) neuron development. We present here rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in DA neuron differentiation...
  39. pmc Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
    Yoshimitsu Doi
    Departments of Immunology and Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 105:8381-6. 2008
    ..DNA microarray analysis previously showed that NR4A2, an orphan nuclear receptor, is strongly up-regulated in the peripheral blood T cells of MS...
  40. doi Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
    Daniela Omodei
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy
    Development 135:3459-70. 2008
    ..genes Ngn2 and Mash1 is not activated in Sox2+ mesDA progenitors, which largely fail to differentiate into Nurr1+ mesDA precursors...
  41. doi Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex
    Anna Hoerder-Suabedissen
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Cereb Cortex 19:1738-50. 2009
    ..subplate-selective expression of complexin 3, connective tissue growth factor, nuclear receptor-related 1/Nr4a2, and monooxygenase Dbh-like 1 while transmembrane protein 163 also had additional expression in layer 5, and DOPA ..
  42. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
    ..Thus far, specification of the dopaminergic phenotype of mdDA neurons is largely attributed to the orphan nuclear receptor Nurr1. In this study, we provide evidence for extensive interplay between Nurr1 and the homeobox ..
  43. pmc A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California, CA 92093, USA
    Cell 137:47-59. 2009
    b>Nurr1, an orphan nuclear receptor, plays an essential role in the generation and maintenance of dopaminergic neurons in the brain...
  44. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
  45. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
    The orphan nuclear receptor Nurr1 is essential for the development of meso-diencephalic dopamine (mdDA) neurons and is required, together with the homeobox transcription factor Pitx3, for the expression of genes involved in dopamine ..
  46. pmc Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons
    Dong Youn Hwang
    Molecular Neurobiology Laboratory, McLean Hospital and Harvard Medical School, Belmont, MA, USA
    J Neurochem 111:1202-12. 2009
    ..As the two genes have been known to be regulated by Nurr1, another key dopaminergic transcription factor, we propose that Pitx3 and Nurr1 may coordinately regulate mDA ..
  47. doi Delayed dopaminergic neuron differentiation in Lrp6 mutant mice
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Dev Dyn 239:211-21. 2010
    ..A transient 50% reduction in tyrosine hydroxylase-positive DA neurons and in the expression of DA markers such as Nurr1 and Pitx3, as well as a defect in midbrain morphogenesis was detected in the mutant embryos at embryonic day 11.5...
  48. pmc Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    Sangmi Chung
    Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Cell Stem Cell 5:646-58. 2009
    ..We found that the Wnt1-Lmx1a autoregulatory loop directly regulates Otx2 through the beta-catenin complex and Nurr1 and Pitx3 through Lmx1a...
  49. doi Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon
    Tomoya Nakatani
    KAN Research Institute Inc, Kobe MI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Biol 339:101-13. 2010
    ....
  50. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..two mechanisms and how such interactions can be targeted to promote a maximal production of dopamine neurons are not fully understood...
  51. doi Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
    Michela Di Salvio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Nat Neurosci 13:1481-8. 2010
    ..These findings indicate that Otx2 is required to specify neuron subtype identity in VTA and may antagonize vulnerability to the Parkinsonian toxin MPTP...
  52. pmc The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
    Olga Sirin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 12:1213-9. 2010
    ..Here, we demonstrate that Nurr1, a nuclear receptor transcription factor, has such a regulatory role...
  53. pmc The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
    Takashi Sekiya
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Nat Commun 2:269. 2011
    ..Here we show that Foxp3 is one of the direct targets of Nr4a2. Nr4a2 binds to regulatory regions of Foxp3, where it mediates permissive histone modifications...
  54. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
    Development of meso-diencephalic dopamine (mdDA) neurons requires the combined actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription factor Pitx3...
  55. pmc Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
    Emma R Andersson
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Center of Developmental Biology for Regenerative Medicine, and Department of Cell and Molecular Biology, Karolinska Institute, Stockholm 171 77, Sweden
    Proc Natl Acad Sci U S A 110:E602-10. 2013
    ..Analysis of Wnt1(-/-);Wnt5a(-/-) mice revealed a greater loss of Nurr1(+) cells and DA neurons than in single mutants, indicating that Wnt1 and Wnt5a interact genetically and cooperate ..
  56. pmc Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development
    Jasmine Yang
    Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, 70 Ship Street, Providence, RI 02903, USA
    Development 140:1342-52. 2013
    ..between the one-somite and the six- to eight-somite stages and is solely dependent on Wnt1 function in the Mb, but not in the Cb...
  57. ncbi Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine
    Cristina Backman
    Cellular Neurobiology Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21221, USA
    Behav Brain Res 143:95-100. 2003
    Gene targeting experiments, in which both alleles of the Nurr1 gene were deleted, have shown that this molecule plays an essential role in the development of midbrain dopaminergic neurons, as shown by the loss of dopaminergic markers and ..
  58. pmc Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice
    Elise Nsegbe
    Karolinska Institutet, Neonatal Unit, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    J Physiol 556:43-59. 2004
    b>Nurr1, a transcription factor belonging to the family of nuclear receptors, is expressed at high levels immediately after birth...
  59. ncbi Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice
    Syed Z Imam
    South Texas Veteran Health Care System and Department of Medicine of UT Health Science, San Antonio, Texas, USA
    FASEB J 19:1441-50. 2005
    Knocking out of Nurr1 gene, a member of nuclear receptor superfamily, causes selective agenesis of dopaminergic neurons in midbrain...
  60. doi Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons
    Shanzheng Yang
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 1, 17177 Stockholm, Sweden
    Development 140:4554-64. 2013
    ..here that Cxcl12 is expressed in the meninges surrounding the ventral midbrain (VM), whereas CXCR4 is present in NURR1(+) mDA precursors and mDA neurons from E10.5 to E14.5...
  61. pmc Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain
    Navneet A Vasistha
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Cereb Cortex 25:3290-302. 2015
    The individual contribution of different progenitor subtypes towards the mature rodent cerebral cortex is not fully understood...
  62. pmc Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
    Xin Heng
    Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Mol Neurodegener 7:4. 2012
    NURR1 (also named as NR4A2) is a member of the steroid/thyroid hormone receptor family, which can bind to DNA and modulate expression of target genes...
  63. doi miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
    Dehua Yang
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Cell Sci 125:1673-82. 2012
    ..of dopamine neurons by directly regulating the expression of Nurr1 (also known as nuclear receptor subfamily 4 group A member 2; Nr4a2)...
  64. pmc Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain
    Darren J Yip
    Regenerative Medicine Program, Ottawa Hospital Research Institute, and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada
    Dev Cell 22:871-8. 2012
    ..We demonstrate that Snf2l binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2l and Foxg1 function antagonistically to regulate brain size...
  65. doi Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages
    Simon R W Stott
    Developmental Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 33:8022-34. 2013
    ..Further analysis demonstrated that the reduction in the number of TH+ cells in the mutant mice was not due to apoptosis or cell-fate change...
  66. ncbi Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene
    S O Castillo
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
    Genomics 41:250-7. 1997
    We have cloned and characterized the organization of the mouse orphan nuclear receptor Nurr1 gene. The Nurr1 gene is approximately 7 kb long, contains eight exons and seven introns, and mapped to mouse chromosome 2...
  67. ncbi An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochim Biophys Acta 1444:69-79. 1999
    NGFI-B, Nurr1 and NOR-1 constitute a distinct subfamily within the nuclear receptor superfamily...
  68. ncbi Distribution of the orphan nuclear receptor Nurr1 in medaka (Oryzias latipes): cues to the definition of homologous cell groups in the vertebrate brain
    M Kapsimali
    Development, Evolution, and Plasticity of the Nervous System, UPR 2197, Institut de Neurobiologie A Fessard, CNRS, Gif sur Yvette, 91198 France
    J Comp Neurol 431:276-92. 2001
    The orphan nuclear receptor Nurr1 has been extensively studied in mammals and shown to contribute to the differentiation of several cell phenotypes in the nervous and endocrine systems...
  69. pmc Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation
    E H Chartoff
    Graduate Program in Neurobiology and Behavior, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 98:10451-6. 2001
    ..WT mice were unaffected by C/L-DOPA treatments. A D1, but not a D2, receptor antagonist attenuated both the C/L-DOPA-induced stereotypy and the c-fos induction...
  70. ncbi Generation of tyrosine hydroxylase-immunoreactive neurons in ventral mesencephalic tissue of Nurr1 deficient mice
    Nina Tornqvist
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res Dev Brain Res 133:37-47. 2002
    b>Nurr1 is an orphan nuclear receptor belonging to the family of evolutionary conserved steroid/thyroid hormone receptors...
  71. ncbi Murine Lix1, a novel marker for substantia nigra, cortical layer 5, and hindbrain structures
    Carsten Moeller
    Max Planck Institute of Experimental Endocrinology, Hanover 30625, Germany
    Brain Res Gene Expr Patterns 1:199-203. 2002
    ..Limb buds and facial primordia show transient expression. The prominent expression of mLix1 in the developing cerebral cortex and in the substantia nigra pars compacta makes this novel gene a candidate marker for both of these tissues...
  72. ncbi Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts
    Johanna Lammi
    Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland
    Mol Endocrinol 18:1546-57. 2004
    The orphan nuclear receptor Nurr1 is mainly expressed in the central nervous system but is also detected in certain peripheral tissues such as bone...
  73. ncbi Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts
    Flavia Q Pirih
    Division of Diagnostic and Surgical Sciences and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 279:53167-74. 2004
    b>Nurr1, an NGFI-B nuclear orphan receptor, which transactivates promoters through an NGFI-B response element (NBRE), is strongly induced by parathyroid hormone through the cAMP-protein kinase A signaling pathway in osteoblasts...
  74. ncbi The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta
    Sandrine Thuret
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1302-11. 2004
    ..mesencephalic dopaminergic neurons, found in the substantia nigra and in a subregion of the ventral tegmentum but not in the retrorubral field...
  75. pmc MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling
    Joanne Darragh
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 390:749-59. 2005
    ..MSKs were also found to be required for the transcription of two genes related to Nur77, Nurr1 and Nor1, which were also transcribed in a CREB- or ATF1 (activating transcription factor-1)-dependent manner...
  76. ncbi Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
    Lachlan H Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 198:183-98. 2006
    ..The results show that surviving mesDA neurons in VM grafts are derived from early postmitotic, probably Nurr1-expressing precursors before they have acquired their fully differentiated neuronal phenotype...
  77. ncbi Regulation of osteoblast differentiation by Nurr1 in MC3T3-E1 cell line and mouse calvarial osteoblasts
    Mi Kyeong Lee
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biochem 99:986-94. 2006
    The orphan nuclear receptor Nurr1 is primarily expressed in the central nervous system. It has been shown that Nurr1 is necessary for terminal differentiation of dopaminergic (DA) neurons in ventral midbrain...
  78. ncbi Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice
    Jeffrey B Eells
    National Institute for Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 70:186-95. 2006
    The nuclear receptor Nurr1 is essential for the development of midbrain dopamine neurons and appears to be an important regulator of dopamine levels as adult Nurr1-null heterozygous (+/-) mice have reduced mesolimbic/mesocortical ..
  79. ncbi A novel mode of tangential migration of cortical projection neurons
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Plank Institute for Experimental Medicine, 37075 Gottingen, Germany
    Dev Biol 298:299-311. 2006
    ..that these neurons are derived from Emx1+ cortical progenitors and express the transcription factor Satb2 but do not express GABA or Olig1...
  80. doi SOX5 controls the sequential generation of distinct corticofugal neuron subtypes
    Tina Lai
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neuron 57:232-47. 2008
    ..These data indicate that SOX5 controls the timing of critical fate decisions during corticofugal neuron production and thus subtype-specific differentiation and neocortical neuron diversity...
  81. doi FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts
    Johanna Lammi
    Institute of Biomedicine Physiology, Biomedicum Helsinki, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    Mol Cell Endocrinol 295:87-93. 2008
    b>Nurr1, NGFI-B, and Nor1 form the NR4A subfamily of orphan nuclear receptors. The NR4A receptors are immediate early genes that can be rapidly induced in response to a variety of stimuli in many cell types, for example, in osteoblasts...
  82. pmc Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1
    Lily C Chao
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California 90095 1662, USA
    Mol Endocrinol 22:2596-608. 2008
    ..Retroviral transduction of each of the NR4A receptors (Nur77, Nurr1, and NOR1) into either 3T3-L1 or 3T3-F442A preadipocytes potently inhibits adipogenesis...
  83. doi Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons
    Chao Guo
    Institute of Neuroscience, Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 28:14097-106. 2008
    ..We found that mDA neurons revealed by tyrosine hydroxylase (TH), Pitx3, Nurr1, and dopamine transporter were indistinguishable from wild-type controls during embryonic development as well as ..
  84. doi Nurr1 expression and its modulation in microglia
    Xiaolan Fan
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Neuroimmunomodulation 16:162-70. 2009
    b>Nurr1, a transcription factor essential for the differentiation and maturation of central dopaminergic cells, is primarily expressed in neurons of the central nervous system...
  85. doi Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues
    Stephen A Myers
    The University of Queensland, Institute for Molecular Biosciences, QBP, St Lucia, Queensland, 4072, Australia
    Mol Cell Endocrinol 309:101-8. 2009
    ..hormone receptor (NR) 4A subgroup of orphan nuclear receptors includes three members, Nur77 (NR4A1), Nurr1 (NR4A2) and Nor-1 (NR4A3)...
  86. doi Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
    Sebastian Stuebner
    Institute of Developmental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, and Technical University Munich, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Dev Dyn 239:246-60. 2010
    ..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse...
  87. doi Involvement of nuclear factor-kB and Nurr-1 in cytokine-induced transcription of proopiomelanocortin gene in AtT20 corticotroph cells
    Shinobu Takayasu
    Department of Endocrinology and Metabolism, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuroimmunomodulation 17:88-96. 2010
    ..We examined whether transcription factors nuclear factor (NF)-kappaB and Nurr-1 are involved in the cytokine-induced proopiomelanocortin (POMC) gene expression...
  88. doi Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice
    Patricia Rojas
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 88:2284-93. 2010
    The immediate-early gene Nurr1 is a member of the inducible orphan nuclear receptor family...
  89. pmc NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection
    Nikolaos Volakakis
    Ludwig Institute for Cancer Research, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:12317-22. 2010
    ..These data identify NR4A nuclear orphan receptors as essential mediators of neuroprotection after exposure to neuropathological stress...
  90. pmc Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation
    Daren Low
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, Singapore
    Eur J Hum Genet 18:1228-35. 2010
    ..quantitative reverse-transcription PCR, we validated the differential expression of genes (Fgf7, Glra1, Mc1r, Nr4a2, Slc5a7 and Epha6) that show functional relevance to AS phenotype...
  91. pmc Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity
    Shirong Wang
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, Washington 98101, USA
    J Neurosci 30:9224-7. 2010
    ..Here we show that Etv5 expression is not detectable until postnatal stages in the midbrain, well after development of the DA system, and that Etv5 knock-out ..
  92. pmc Identification of NURR1 as a mediator of MIF signaling during chronic arthritis: effects on glucocorticoid-induced MKP1
    Jennifer A Ralph
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, 246 Clayton Rd, Clayton, Melbourne 3168, Australia
    Am J Pathol 177:2366-78. 2010
    ..We investigated NURR1, a GC-responsive transcription factor overexpressed in RA, as a MIF signaling target...
  93. pmc Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity
    Yongsu Jeong
    Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin si, Gyeonggi Do, Republic of Korea
    Development 138:531-41. 2011
    ..In SBE1 mutant mice, Shh transcription was initiated but not maintained in the ventral midline of the rostral midbrain and caudal diencephalon, yet expression in the zli was ..
  94. doi Cross-talk between NR4A orphan nuclear receptors and β-catenin signaling pathway in osteoblasts
    Ann Marie Rajalin
    Institute of Biomedicine Physiology, Biomedicum Helsinki, University of Helsinki, Finland
    Arch Biochem Biophys 509:44-51. 2011
    ..NR4A orphan nuclear receptors (Nurr1, NGFI-B, and Nor1) are expressed in osteoblasts and have been shown to regulate the expression of osteoblastic ..
  95. doi Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation
    Anders Lundequist
    Swedish University of Agricultural Sciences, Dept of Anatomy, Physiology and Biochemistry, BMC, Box 575, 75123 Uppsala, Sweden
    Mol Immunol 48:1753-61. 2011
    ..In response to purified LPS, strong upregulation of Nr4a3, but not of Nr4a1 or Nr4a2 was seen. Nr4a3 expression was also induced after the activation of BMMCs by IgE receptor cross-linking...
  96. doi Relationship between sensorimotor gating deficits and dopaminergic neuroanatomy in Nurr1-deficient mice
    Stéphanie Vuillermot
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Exp Neurol 232:22-32. 2011
    Nurr1 (NR4A2) is an orphan nuclear receptor highly essential for the development and maintenance of dopaminergic neurons...
  97. ncbi NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3
    H W Mages
    Max Planck Society Research Unit for Immunology Rheumatology, Erlangen, Germany
    Mol Endocrinol 8:1583-91. 1994
    ..Sequence comparison revealed that NOT is the human homolog of the murine NURR1 and rat RNR-1. Moreover NOT is closely related to NAK1/TR3, a previously identified human orphan steroid receptor...
  98. ncbi HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures
    S PENA DE ORTIZ
    Department of Environmental Health, University of Cincinnati College of Medicine, OH 45267 0056, USA
    Brain Res Mol Brain Res 38:1-13. 1996
    ..HZF-3 cDNA encodes a 66.6-kDa protein with high homology to the inducible nuclear orphan receptors NURR1/NOT and NGFI-B...
  99. ncbi Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Endocrinol 10:1656-66. 1996
    NGFI-B, Nurr1, and Nor1 are three closely related orphan members of the steroid/thyroid hormone receptor superfamily. These receptors can bind to DNA as monomers and exhibit constitutive transcriptional activity...
  100. ncbi Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1
    O Saucedo-Cardenas
    Baylor College of Medicine, Department of Cell Biology, Houston, TX 77030, USA
    Gene 187:135-9. 1997
    b>NURR1 is an immediate early gene product and a member of the nuclear receptor superfamily of transcription factors. Using the NURR1 cDNA as a probe, we isolated the genomic DNA encoding NURR1 from a mouse 129SvEv genomic library...
  101. ncbi Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice
    K Y Tseng
    Departamento de Fisiologia y Biofisica, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Brain Res Mol Brain Res 80:1-6. 2000
    The orphan nuclear receptor Nurr1 is critical for the survival of mesencephalic dopaminergic precursor neurons. Little is known about the mechanisms that regulate Nurr1 expression in vivo...

Research Grants2

  1. Proteome analysis in mice expressing P301L tau
    Irving Vega; Fiscal Year: 2005
    ..These approaches may contribute to the identification of important biological markers involved at early stages of the development of tauopathy and may bring insights into the molecular mechanism underline tau aggregation ..
  2. Identification of Genes for Alcohol Preference in Noninbred Rats and Mice
    Paula Bice; Fiscal Year: 2009
    ..abstract_text> ..