Nr1h3

Summary

Gene Symbol: Nr1h3
Description: nuclear receptor subfamily 1, group H, member 3
Alias: AU018371, LXR, RLD1, Unr1, oxysterols receptor LXR-alpha, LXR alpha, liver X receptor alpha, ubiquitously-expressed nuclear receptor 1
Species: mouse

Top Publications

  1. ncbi BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
    Peter A Edwards
    Departments of Biological Chemistry and Medicine, CHS 33 257, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Lipid Res 43:2-12. 2002
  2. ncbi LXR-dependent gene expression is important for macrophage survival and the innate immune response
    Sean B Joseph
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 119:299-309. 2004
  3. pmc Liver X receptors as integrators of metabolic and inflammatory signaling
    Noam Zelcer
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, California 90055 1662, USA
    J Clin Invest 116:607-14. 2006
  4. pmc Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile
    Huaixin Dang
    Department of Physiology and Pathophysiology, Health Science Center, Institute of Cardiovascular Research, Peking University, Beijing, China
    J Biol Chem 284:6218-26. 2009
  5. pmc LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner
    Aurélia Ouvrier
    Universite Blaise Pascal, Unité Mixte de Recherche GReD Centre National de la Recherche Scientifique 6247, INSERM U931, 63177 Aubiere, Cedex, France
    J Lipid Res 50:1766-75. 2009
  6. ncbi Liver X receptor-alpha gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 22 Showa machi Maebashi, Gunma, Japan 371 8511
    Endocrinology 148:4667-75. 2007
  7. pmc Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
    Cynthia Hong
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Lipid Res 52:531-9. 2011
  8. ncbi Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor
    Torsten Plosch
    Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 126:290-300. 2004
  9. ncbi Phospholipid transfer protein is regulated by liver X receptors in vivo
    Guoqing Cao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:39561-5. 2002
  10. ncbi LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function
    Isabelle Gerin
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 280:23024-31. 2005

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
    Peter A Edwards
    Departments of Biological Chemistry and Medicine, CHS 33 257, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Lipid Res 43:2-12. 2002
    ..During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRalpha, NR1H3, and LXRbeta, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) ..
  2. ncbi LXR-dependent gene expression is important for macrophage survival and the innate immune response
    Sean B Joseph
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 119:299-309. 2004
    ..We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses...
  3. pmc Liver X receptors as integrators of metabolic and inflammatory signaling
    Noam Zelcer
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, California 90055 1662, USA
    J Clin Invest 116:607-14. 2006
    ..Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis ..
  4. pmc Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile
    Huaixin Dang
    Department of Physiology and Pathophysiology, Health Science Center, Institute of Cardiovascular Research, Peking University, Beijing, China
    J Biol Chem 284:6218-26. 2009
    ..Paradoxically, an improved hepatic lipid profile by LXR was observed in mice fed a Western high fat (HF) diet...
  5. pmc LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner
    Aurélia Ouvrier
    Universite Blaise Pascal, Unité Mixte de Recherche GReD Centre National de la Recherche Scientifique 6247, INSERM U931, 63177 Aubiere, Cedex, France
    J Lipid Res 50:1766-75. 2009
    ..LXRs), the nuclear receptors for oxysterols, are of major importance in intracellular cholesterol homeostasis, and LXR(-/-)-deficient male mice have already been shown to have reduced fertility at an age of 5 months and complete ..
  6. ncbi Liver X receptor-alpha gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 22 Showa machi Maebashi, Gunma, Japan 371 8511
    Endocrinology 148:4667-75. 2007
    ..In the current study, we demonstrated that thyroid hormone (T(3)) up-regulated mouse LXR-alpha, but not LXR-beta, mRNA expression in the liver and that cholesterol administration did not affect the LXR-..
  7. pmc Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
    Cynthia Hong
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Lipid Res 52:531-9. 2011
    ..One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects...
  8. ncbi Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor
    Torsten Plosch
    Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 126:290-300. 2004
    ..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen...
  9. ncbi Phospholipid transfer protein is regulated by liver X receptors in vivo
    Guoqing Cao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:39561-5. 2002
    Liver X receptors (LXR) belong to the nuclear receptor superfamily that can regulate important lipid metabolic pathways...
  10. ncbi LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function
    Isabelle Gerin
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 280:23024-31. 2005
    Liver X receptors (LXR) alpha and beta are nuclear oxysterol receptors with established roles in cholesterol, lipid, and carbohydrate metabolism...
  11. ncbi Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
    J M Lehmann
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 272:3137-40. 1997
    ..In addition, we have identified an LXR response element in the promoter region of the rat cholesterol 7alpha-hydroxylase gene...
  12. ncbi Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    D J Peet
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 93:693-704. 1998
    We demonstrate that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in excess of that which they synthesize de novo...
  13. ncbi Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Science 289:1524-9. 2000
    ..Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine...
  14. pmc Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 14:2819-30. 2000
    ..In this report, we describe a novel LXR target, the sterol regulatory element-binding protein-1c gene (SREBP-1c), which encodes a membrane-bound ..
  15. pmc LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    B A Laffitte
    Howard Hughes Medical Institute, Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:507-12. 2001
    ..We show that LXR/RXR heterodimers regulate apoE transcription directly, through interaction with a conserved LXR response element ..
  16. pmc Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    S Alberti
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Clin Invest 107:565-73. 2001
    ..We have generated mouse lines with targeted disruptions of each of these LXR receptors and have compared their responses to dietary cholesterol...
  17. ncbi Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages
    K D Whitney
    GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:43509-15. 2001
    The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol...
  18. ncbi Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis
    Kari Anne Risan Tobin
    Institute for Nutrition Research and Institute of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 277:10691-7. 2002
    The nuclear receptor liver X receptor (LXR) alpha, an important regulator of cholesterol and bile acid metabolism, was analyzed after insulin stimulation in liver in vitro and in vivo...
  19. ncbi Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    Joyce J Repa
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 277:18793-800. 2002
    ..Here we demonstrate that the ABCG5 and ABCG8 genes are direct targets of the oxysterol receptors liver X receptor (LXR) alpha and LXRbeta...
  20. ncbi Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system
    Karl D Whitney
    GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 16:1378-85. 2002
    The nuclear oxysterol receptors liver X receptor-alpha [LXRalpha (NR1H3)] and LXRbeta (NR1H2) coordinately regulate genes involved in cholesterol homeostasis...
  21. ncbi Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
    Aldo Grefhorst
    Laboratory of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Hanzeplein 1, 9713 RB Groningen, The Netherlands
    J Biol Chem 277:34182-90. 2002
    The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid metabolism; activation of LXR induces transcription of lipogenic genes...
  22. ncbi Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    Torsten Plosch
    Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, Department of Pediatrics, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Biol Chem 277:33870-7. 2002
    ..Expression of the Abca1 gene is under control of the liver X receptor (LXR)...
  23. pmc Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism
    Sarah E Ross
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 22:5989-99. 2002
    ..we used the microarray data to identify potentially important adipocyte genes and chose one of these, the liver X receptor alpha (LXR alpha), for further analyses...
  24. ncbi Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors
    George E O Muscat
    X Ceptor Therapeutics, Inc, 4757 Nexus Centre Drive, San Diego, CA 92121, USA
    J Biol Chem 277:40722-8. 2002
    ..Furthermore we show that treatment of muscle cells in vitro with synthetic agonists of LXR increases the efflux of intracellular cholesterol to extracellular acceptors such as high density lipoprotein, thus ..
  25. pmc Identification of macrophage liver X receptors as inhibitors of atherosclerosis
    Rajendra K Tangirala
    X Ceptor Therapeutics, 4757 Nexus Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:11896-901. 2002
    Recent studies have identified the liver X receptors (LXR alpha and LXR beta) as important regulators of cholesterol metabolism and transport...
  26. ncbi Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
    Liver X receptor (LXR) alpha and LXRbeta are nuclear oxysterol receptors whose biological function has so far been elucidated only with respect to cholesterol and lipid metabolism...
  27. ncbi Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    Sean B Joseph
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Nat Med 9:213-9. 2003
    ..Transcriptional profiling of lipopolysaccharide (LPS)-induced macrophages reveals reciprocal LXR-dependent regulation of genes involved in lipid metabolism and the innate immune response...
  28. ncbi Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages
    Antonio Castrillo
    Howard Hughes Medical Institute, University of California, Los Angeles 90095, USA
    J Biol Chem 278:10443-9. 2003
    ..Treatment of murine peritoneal macrophages with the synthetic LXR agonists GW3965 or T1317 reduces MMP-9 mRNA expression and blunts its induction by pro-inflammatory stimuli ..
  29. ncbi On the role of liver X receptors in lipid accumulation in adipocytes
    Lene K Juvet
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    Mol Endocrinol 17:172-82. 2003
    ..We have studied the role of LXR in fat cells and demonstrate that LXR is regulated during adipogenesis and augments fat accumulation in mature ..
  30. ncbi Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
    Liqing Yu
    McDermott Center for Human Growth and Development, Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    J Biol Chem 278:15565-70. 2003
    Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the trafficking of sterols between tissues...
  31. ncbi Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling
    Tomohiro Ide
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Mol Endocrinol 17:1255-67. 2003
    ..fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis...
  32. ncbi Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions
    J M Frenoux
    Epididyme et Maturation des Gamètes, CNRS UMR 6547 GEEM, Universite Blaise Pascal, 24, avenue des Landais, 63177 Aubiere, France
    J Mol Endocrinol 33:361-75. 2004
    In this study we looked at the epididymides and spermatozoa of mice knocked-out for nuclear oxysterol receptors (LXR)...
  33. ncbi Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells
    Alexander M Efanov
    Lilly Research Laboratories, Essener Strasse 93, D 22419 Hamburg, Germany
    Diabetes 53:S75-8. 2004
    ..Culture of pancreatic islets or insulin-secreting MIN6 cells with a LXR specific agonist T0901317 caused an increase in glucose-dependent insulin secretion and islet insulin content...
  34. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ..In addition, combined activation of LXR and RXR protected macrophages from apoptosis caused by infection with Bacillus anthracis, Escherichia coli, and ..
  35. ncbi The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis
    Kirsten M Robertson
    Karolinska Institutet, Department of Biosciences at Novum, Huddinge 14157, Sweden
    Endocrinology 146:2519-30. 2005
    The liver X receptor (LXR)alpha and -beta has been found to play a central role in maintaining cellular cholesterol homeostasis...
  36. ncbi LXRs regulate the balance between fat storage and oxidation
    Nada Y Kalaany
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell Metab 1:231-44. 2005
    ..Here we show that LXR null mice are defective in hepatic lipid metabolism and are resistant to obesity when challenged with a diet ..
  37. ncbi Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha
    Tonghuan Hu
    Lilly Research Laboratories, Department of Cardiovascular Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 146:5380-7. 2005
    ..In this study we provide evidence that the liver X receptor (LXR) regulates the expression of the genetic program for peroxisomal beta-oxidation in liver...
  38. ncbi Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    J Biol Chem 281:295-302. 2006
    ..reduced hepatic cholesterol content in MUT animals are likely because of cross-talk between TR-beta and liver X receptor alpha (LXR-alpha), which both bind to a direct repeat + 4 (DR+4) element in the CYP7A1 promoter...
  39. pmc Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    Kiki Chu
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Mol Cell Biol 26:6786-98. 2006
    ..In this study, we investigated the regulation of mouse SCD1 by liver X receptor (LXR) and its role in plasma lipoprotein metabolism upon LXR activation...
  40. ncbi Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus
    Kevin Mouzat
    UMR CNRS 6547, LXRs, Oxysterols, and Steroidogenic Tissues, and Research Center for Human Nutrition, 63177 Aubiere, France
    J Biol Chem 282:4693-701. 2007
    ..Upon treatment with an LXR agonist that mimics activation by oxysterols, expression of these target genes was increased in wild-type mice, ..
  41. ncbi Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility
    David H Volle
    Physiologie Comparée et Endocrinologie Moléculaire, Unite Mixte de Recherche, Centre National de la Recherche Scientifique CNRS 6547, 63177 Aubiere Cedex, France
    Mol Endocrinol 21:1014-27. 2007
    Oxysterol nuclear receptors liver X receptor (LXR)alpha and LXRbeta are known to regulate lipid homeostasis in cells exposed to high amounts of cholesterol and/or fatty acids...
  42. ncbi Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells
    Sung Sik Choe
    Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Sillim dong, Kwanak gu, Seoul, Korea
    Diabetes 56:1534-43. 2007
    Liver X receptor (LXR)alpha and LXRbeta play important roles in fatty acid metabolism and cholesterol homeostasis...
  43. pmc Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE
    Michelle N Bradley
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California 90095 1662, USA
    J Clin Invest 117:2337-46. 2007
    ..However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain unclear...
  44. ncbi SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    Xiaoling Li
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 28:91-106. 2007
    ..Here we show that SIRT1 is a positive regulator of liver X receptor (LXR) proteins, nuclear receptors that function as cholesterol sensors and regulate whole-body cholesterol and lipid ..
  45. pmc Androgen deprivation by activating the liver X receptor
    Jung Hoon Lee
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Endocrinology 149:3778-88. 2008
    ..Genetic or pharmacological activation of the liver X receptor (LXR) in vivo lowered androgenic activity by inducing the hydroxysteroid sulfotransferase 2A1, an enzyme essential for ..
  46. pmc LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    Steven J Bensinger
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90049, USA
    Cell 134:97-111. 2008
    ..that cellular cholesterol levels in dividing T cells are maintained in part through reciprocal regulation of the LXR and SREBP transcriptional programs...
  47. doi Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
    Z X Meng
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Clinical Diabetes Centre of Jiangsu Province, Nanjing Medical University, Nanjing, People s Republic of China
    Diabetologia 52:125-35. 2009
    ..However, the roles of LXRs in pancreatic beta cells have not been fully established. The aim of this study was to investigate the effects of LXRs on pancreatic beta cell proliferation...
  48. pmc The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
    Inna Astapova
    Division of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19544-9. 2008
    ..Interestingly, NCoR recruitment to LXR is also impaired in this model, leading to activation of LXR-target genes, further demonstrating that NCoR ..
  49. pmc Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice
    Hyun Jin Kim
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum S 14186, Sweden
    Proc Natl Acad Sci U S A 106:558-63. 2009
    With specific liver X receptor alpha and beta (LXRalpha and LXRbeta) antibodies, we found that LXRalpha is strongly expressed in the luminal and basal cells of prostatic epithelium...
  50. doi Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c
    Yan Qin
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    Biochim Biophys Acta 1791:140-7. 2009
    ..We demonstrate that Liver X Receptor alpha (LXRalpha) and sterol regulatory binding protein-1c (SREBP-1c) regulate hepatic Elovl5 expression...
  51. pmc Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
    Hannelie Korf
    Laboratory of Mycobacterial Immunology, Scientific Institute of Public Health, Brussels, Belgium
    J Clin Invest 119:1626-37. 2009
    ..Upon intratracheal infection with M. tuberculosis, LXRs and LXR target genes were induced in CD11c+ lung and alveolar cells...
  52. pmc Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    Noelia A-Gonzalez
    Immune Signaling Laboratory, Department of Biochemistry and Molecular Biology, School of Medicine, University of Las Palmas, ULPGC, 35016 Las Palmas, Spain
    Immunity 31:245-58. 2009
    ..We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance...
  53. pmc Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    Ebru Erbay
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 15:1383-91. 2009
    ....
  54. doi Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
    Eduardo J Villablanca
    Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
    Nat Med 16:98-105. 2010
    ..was also observed in chimeric mice transplanted with bone marrow from mice lacking the gene encoding LXR-alpha (Nr1h3(-/-) mice) Thus, we show a new mechanism of tumor immunoescape involving products of cholesterol metabolism...
  55. pmc Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
    Eric D Bischoff
    Exelixis, Inc, San Diego, CA, USA
    J Lipid Res 51:900-6. 2010
    ..activity of LXRalpha and LXRbeta and determine the ability of each subtype to mediate the biological response to LXR agonists...
  56. pmc LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
    Rucha Patel
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 121:431-41. 2011
    ..Here, we show LXRβ is required to mediate many of the negative side effects of glucocorticoids...
  57. pmc Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
    Guoliang Cui
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of CAS, Chinese Academy of Sciences, Shanghai, China
    J Clin Invest 121:658-70. 2011
    ..We report here that ectopic expression of liver X receptor (LXR) inhibits Th17 polarization of mouse CD4+ T cells, while LXR deficiency promotes Th17 differentiation in vitro...
  58. doi Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
    Marion Korach-Andre
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institutet, Lipid Laboratory, Huddinge, Sweden
    Am J Physiol Endocrinol Metab 301:E210-22. 2011
    ..Recently, LXRs have been proposed as a glucose sensor affecting LXR-dependent gene expression...
  59. pmc Coordinate regulation of neutrophil homeostasis by liver X receptors in mice
    Cynthia Hong
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    J Clin Invest 122:337-47. 2012
    ..Using gain- and loss-of-function models, we found that LXR signaling regulated the efficient clearance of senescent neutrophils by peripheral tissue APCs in a Mer-dependent ..
  60. pmc Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites
    Michael Boergesen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    Mol Cell Biol 32:852-67. 2012
    ..RXR agonist-induced hypertriglyceridemia and hepatic steatosis in mice are dependent on LXRs and correlate with an LXR-dependent hepatic induction of lipogenic genes...
  61. doi Lxrα regulates the androgen response in prostate epithelium
    Emilie Viennois
    Department of Génétique Reproduction et Développement, Clermont Universite, F 63000 Clermont Ferrand, France
    Endocrinology 153:3211-23. 2012
    ..We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of ..
  62. doi MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7
    Dongsheng Sun
    Department of Geriatrics, Zhejiang Provincial People s Hospital, Hangzhou, PR China
    FEBS Lett 586:1472-9. 2012
    ..regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled...
  63. doi A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα
    Simon Ducheix
    INRA, UMR1331, Toxalim, Research Centre in Food Toxicology, Universite de Toulouse, Toulouse, France
    Biochimie 95:556-67. 2013
    ..As expected, T0901317 and fenofibrate induce expression of genes involved LXR-dependent and PPARα-dependent lipogenic responses...
  64. doi Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
    Amena Archer
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institute, S 141 83 Huddinge, Sweden
    Mol Endocrinol 26:1980-90. 2012
    ..We hypothesized that the LXR transcription factors could influence Fgf21 expression, which is induced in response to fasting...
  65. ncbi Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 310:589-93. 2003
    The nuclear receptors liver X receptors (LXR) alpha and beta are important regulators of genes involved in lipid, cholesterol, and carbohydrate metabolism and are highly expressed in mature adipocyte tissue...
  66. ncbi Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue
    Stine Marie Ulven
    Department of Nutrition, University of Oslo, N 0316 Oslo, Norway
    J Lipid Res 45:2052-62. 2004
    ..LXRalpha gene is highly induced in vivo and in vitro in mouse and human adipocytes in the presence of the synthetic LXR agonist T0901317...
  67. ncbi Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice
    Torsten Plosch
    Center for Liver, Digestive, and Metabolic Diseases, Laboratory of Pediatrics, Univ Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 291:G414-23. 2006
    ..Treatment with the liver X receptor (LXR) agonist T0901317 increased the maximal sterol excretion capacity in wild-type mice (fourfold), concomitant with ..
  68. pmc Liver X receptors regulate adrenal cholesterol balance
    Carolyn L Cummins
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    J Clin Invest 116:1902-12. 2006
    ..in all aspects of cholesterol utilization, including the steroidogenic acute regulatory protein, StAR, a novel LXR target. Under chronic dietary stress, adrenal glands from Lxralphabeta-/- mice accumulated free cholesterol...
  69. pmc LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    Noam Zelcer
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 325:100-4. 2009
    ..Here we show that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeostasis, not only through promotion of cholesterol efflux but also through ..
  70. doi Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines
    Z X Meng
    Department of Biochemistry and Molecular Biology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, People s Republic of China
    Diabetologia 55:1733-44. 2012
    Liver X receptors (LXR) are important transcriptional regulators of lipid and glucose metabolism. Our previous report demonstrated that LXR activation inhibited pancreatic beta cell proliferation through cell cycle arrest...
  71. doi Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages
    Kirsten M Robertson Remen
    Dept of Biosciences and Nutrition at NOVUM, Huddinge, Sweden
    J Leukoc Biol 93:71-82. 2013
    ..The LXRα and -β are important modulators of inflammatory signaling and can potently inhibit RANKL-induced osteoclast ..
  72. pmc Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance
    Simon W Beaven
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Cell Metab 18:106-17. 2013
    ..We show that LXRs modulate key aspects of the metabolic syndrome in mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese but show reduced hepatic steatosis and improved insulin sensitivity ..
  73. ncbi The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism
    Jack Phan
    Department of Medicine, UCLA and the Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 277:469-77. 2002
    ..including cholesterol 7alpha-hydroxylase and sterol-27-hydroxylase, and the oxysterol nuclear receptor liver X receptor alpha. Expression levels for several other genes involved in bile acid metabolism were subsequently found to ..
  74. ncbi Genetic analysis of intestinal cholesterol absorption in inbred mice
    M Schwarz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    J Lipid Res 42:1801-11. 2001
    ....
  75. ncbi Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis
    Laszlo G Komuves
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 118:25-34. 2002
    ..The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation...
  76. ncbi Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Diabetes 51:2426-33. 2002
    ..Liver X receptor (LXR)-alpha and -beta are nuclear oxysterol receptors whose key role in lipid metabolic regulation has recently been ..
  77. ncbi Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:953-67. 2003
    ....
  78. ncbi Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:33904-11. 2003
    ..b>Liver X receptor alpha (LXR alpha) agonists and a high carbohydrate fat-free diet induced SCD4 expression, but unlike SCD1, SCD4 ..
  79. ncbi Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha
    Knut Tomas Dalen
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 278:48283-91. 2003
    ..The expression of GLUT4 in WAT is induced by a potent LXR agonist in wild type, LXR alpha-/-, and LXR beta-/- mice but not in LXR alpha-/-beta-/- mice, demonstrating that both LXRs are able to mediate ..
  80. ncbi Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue
    L Lundholm
    Department of Biosciences at Novum, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    J Mol Endocrinol 32:879-92. 2004
    ..17beta-Estradiol was shown to decrease mRNA expression of liver X receptor (LXR) alpha after 10 h of treatment compared with the vehicle control...
  81. ncbi Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein
    Kotoka Nakamura
    Department of Biological Chemistry and Medicine, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 279:45980-9. 2004
    ..The relatively high levels of expression in neuronal tissues and the eye suggest that ABCG1-dependent cholesterol efflux may be critical for normal neuronal function in addition to its role in macrophages...
  82. ncbi Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development
    Geoffroy Marceau
    ARDEMO, Universite d Auvergne, Clermont Ferrand, France
    Anat Rec A Discov Mol Cell Evol Biol 283:175-81. 2005
    ..Lxralpha showed a higher accumulation in the mouse yolk sac. In situ hybridization pointed a specific expression of lxralpha in the human amniotic membranes...
  83. ncbi Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
    ..These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis...
  84. ncbi Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype
    Erik G Lund
    Department of Cardiovascular Diseases, Merck Research Laboratories, Merck and Co, Inc, RY80W 250, P O Box 2000, Rahway, NJ 07065, United States
    Biochem Pharmacol 71:453-63. 2006
    Liver X receptor (LXR) alpha and LXRbeta are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription of genes that control cholesterol efflux and fatty acid biosynthesis...
  85. pmc The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 349:846-54. 2006
    ..Here, we examine the effect of LXR and PPARalpha ligands on MPO expression...
  86. pmc Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
    Noam Zelcer
    Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:10601-6. 2007
    ..We show here that endogenous LXR signaling impacts the development of AD-related pathology...
  87. doi Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor
    Yasutomi Kamei
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Endocrinology 149:2293-305. 2008
    ..These findings provide in vivo and in vitro evidence that RXR/LXR up-regulates SREBP1c gene expression and that FOXO1 antagonizes this effect of RXR/LXR in skeletal muscle.
  88. pmc ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
    Pierre Damien Denechaud
    Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    J Clin Invest 118:956-64. 2008
    ..Using an LXR agonist in wild-type mice, we found that LXR stimulation did not promote ChREBP phosphorylation or nuclear ..
  89. doi OSBP negatively regulates ABCA1 protein stability
    Kristin Bowden
    Department of Pediatrics and Biochemistry and Molecular Biology, Atlantic Research Centre, Dalhousie University, Halifax, NS, Canada
    J Biol Chem 283:18210-7. 2008
    Oxysterol binding to liver X receptors (LXR) increases the transcription of genes involved in cholesterol efflux and disposal, such as ABCA1 (ATP-binding cassette transporter A1)...
  90. pmc Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow
    Chaitra Marathe
    Howard Hughes Medical Institute, Molecular Biology Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:214-24. 2009
    Macrophage lipid metabolism and inflammatory responses are both regulated by the nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic disease progression suggest that PPAR and LXR signaling may alter ..
  91. doi Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Leipzig, Germany
    Arterioscler Thromb Vasc Biol 28:2009-15. 2008
    Background- The nuclear liver X receptor-alpha (LXR-alpha) has been implicated in the regulation of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis susceptibility...
  92. doi Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes
    N Kumar
    Division of Translational Biology, Endocrine Biology Program, The Hamner Institutes for Health Sciences, Six Davis Drive, Research Triangle Park, NC 27709, USA
    Int J Obes (Lond) 33:519-24. 2009
    ..Here, we investigated the role of LXRs to regulate the expression of the nuclear receptor NOR-1 (neuron-derived orphan receptor-1) in adipocytes...
  93. pmc Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling
    Sijie Wu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 435, 1675 University Boulevard, Birmingham, AL 35242, USA
    Cardiovasc Res 84:119-26. 2009
    ..Several members of nuclear receptor superfamily, including liver X receptors (LXRalpha and LXRbeta), have been shown to suppress inflammatory responses, but little is known about their effects in cardiomyocytes...
  94. doi Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice
    Marion Korach-Andre
    Dept of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Am J Physiol Endocrinol Metab 298:E167-78. 2010
    ..We conclude that selective LXRbeta agonists would be novel pharmaceuticals in the treatment of T2D...
  95. pmc REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis
    Gwendal Le Martelot
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, Geneva, Switzerland
    PLoS Biol 7:e1000181. 2009
    ..Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols...
  96. doi LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux
    N P Hessvik
    Dept of Pharmaceutical Biosciences, Univ of Oslo, Norway
    Am J Physiol Endocrinol Metab 298:E602-13. 2010
    ..The present study showed that treatment with the LXR agonist T0901317 increased lipogenesis and apoA1-dependent cholesterol efflux in LXRalpha KO and WT myotubes but ..
  97. doi Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lab Invest 90:630-6. 2010
    Liver X receptor (LXR)-alpha is a pivotal player in reverse cholesterol metabolism. Recently, LXR-alpha was implicated as an immediate regulator of renin expression in a cAMP-responsive manner...
  98. doi Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis
    Giuseppe Lo Sasso
    Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy
    Cell Metab 12:187-93. 2010
    ..Systemic LXR activation via synthetic ligands induces RCT but also causes increased hepatic fatty acid synthesis and steatosis, ..
  99. pmc Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production
    Sinnie Sin Man Ng
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    FEBS Lett 585:1331-7. 2011
    ..These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels...
  100. ncbi Accumulation of foam cells in liver X receptor-deficient mice
    Gertrud U Schuster
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    Circulation 106:1147-53. 2002
    ..The present study aimed to elucidate the physiological relevance of both LXRs with regard to lipid metabolism and macrophage cholesterol efflux...
  101. ncbi Regulation of the angiopoietin-like protein 3 gene by LXR
    Rebecca Kaplan
    Department of Atherosclerosis, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Lipid Res 44:136-43. 2003
    ..In this study, we show that the Angptl3 gene is a direct target of the liver X receptor (LXR). Mice fed a high cholesterol diet exhibited a significant increase in Angptl3 expression in the liver...

Research Grants10

  1. Phase II UDP-glucuronosyltransferases by PXR
    Wen Xie; Fiscal Year: 2007
    ..These include bilirubin and hormonal homeostasis, drug metabolism, and chemical carcinogenesis. ..
  2. PXR Controlled Bile Acid Detoxification in Colon Cancer
    Wen Xie; Fiscal Year: 2008
    ..It is anticipated that the development of selective PXR agonists may represent a novel strategy to eliminate toxic bile acids and to prevent colon cancer. ..
  3. The Hepatoprotective Role of the Orphan Nuclear Receptor LXR
    Wen Xie; Fiscal Year: 2010
    ..Promoter analysis suggested that SULT2A9, GST M1, and MRP2 are transcriptional targets of LXR. We also showed that the VP-LXR1 transgenic mice were more resistant to APAP hepatotoxicity...
  4. Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
    Wen Xie; Fiscal Year: 2011
    ..The most notable is the induction of the Phase II sulfotransferases (SULTs) in the VP-LXRa mice and LXR agonist-treated wild type mice...
  5. THE ROLE OF PLASMA SPHINGOMYELIN IN ATHEROSCLEROSIS
    Xian Cheng Jiang; Fiscal Year: 2004
    ..If the enrichment of SM in plasma has pro-atherogenic activity, as anticipated, then the inhibition of SPT, the key enzyme for SM biosynthesis, could be an important treatment for atherosclerosis. ..
  6. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2006
    ..These studies will reveal if MPO-generated oxidants promote atherosclerosis in mouse models, thereby humanizing existing mouse models, and enabling investigations of the role of MPO-mediated oxidation in atherosclerosis. ..
  7. Recombinant Listeria monocytogenes expressing ALS3: a vaccine against candidiasis
    Kevin Bruhn; Fiscal Year: 2008
    ..Successful completion of these studies will enable development of the vaccine in a future Phase II proposal. [unreadable] [unreadable] [unreadable]..
  8. Identification of Genes Activated by Bile Acids
    Peter Edwards; Fiscal Year: 2009
    ..In addition, these studies will elucidate the role of FXR in glucose, steroid and drug metabolism and in resistance to endotoxin. ..
  9. The Role of Plasma Phospholipid Transfer Protein in Atherosclerosis
    Xian Cheng Jiang; Fiscal Year: 2010
    ....
  10. The effect of macrophage sphingomyelin synthase (SMS) on atherosclerosis
    Xian Cheng Jiang; Fiscal Year: 2010
    ....