Nr1h2

Summary

Gene Symbol: Nr1h2
Description: nuclear receptor subfamily 1, group H, member 2
Alias: AI194859, LXR, LXRB, LXRBSV, LXRbeta, NER1, OR-1, RIP15, Unr, Unr2, oxysterols receptor LXR-beta, LXR beta, liver X receptor beta, retinoid X receptor-interacting protein No.15, ubiquitously-expressed nuclear receptor 2
Species: mouse

Top Publications

  1. ncbi Cholesterol-sensing receptors, liver X receptor alpha and beta, have novel and distinct roles in osteoclast differentiation and activation
    Kirsten M Robertson
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Bone Miner Res 21:1276-87. 2006
  2. ncbi Laminar shear stress regulates liver X receptor in vascular endothelial cells
    Minjia Zhu
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing, China 100083
    Arterioscler Thromb Vasc Biol 28:527-33. 2008
  3. pmc Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons
    Xiaotang Fan
    Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:13445-50. 2008
  4. ncbi Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Science 289:1524-9. 2000
  5. pmc Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 14:2819-30. 2000
  6. pmc LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    B A Laffitte
    Howard Hughes Medical Institute, Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:507-12. 2001
  7. pmc Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    S Alberti
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Clin Invest 107:565-73. 2001
  8. pmc Identification of macrophage liver X receptors as inhibitors of atherosclerosis
    Rajendra K Tangirala
    X Ceptor Therapeutics, 4757 Nexus Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:11896-901. 2002
  9. ncbi Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    Sean B Joseph
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Nat Med 9:213-9. 2003
  10. ncbi Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling
    Tomohiro Ide
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Mol Endocrinol 17:1255-67. 2003

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi Cholesterol-sensing receptors, liver X receptor alpha and beta, have novel and distinct roles in osteoclast differentiation and activation
    Kirsten M Robertson
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Bone Miner Res 21:1276-87. 2006
    ..However, our studies using the LXRalpha-/-, LXRbeta-/-, and LXRalpha-/-beta-/- mice show that both LXRalpha and beta are also important for bone turnover, mainly by ..
  2. ncbi Laminar shear stress regulates liver X receptor in vascular endothelial cells
    Minjia Zhu
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing, China 100083
    Arterioscler Thromb Vasc Biol 28:527-33. 2008
    The liver X receptors (LXRs) regulate a set of genes involved in lipid metabolism and reverse cholesterol transport. We investigated the mechanism by which shear stress regulates LXR in vascular endothelial cells (ECs).
  3. pmc Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons
    Xiaotang Fan
    Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:13445-50. 2008
    ..Here, we have examined the expression pattern of LXRbeta protein in the cerebral cortex and looked for defects in cortical development in LXRbeta knockout (LXRbeta(-/-)) ..
  4. ncbi Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Science 289:1524-9. 2000
    ..Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine...
  5. pmc Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 14:2819-30. 2000
    ..In this report, we describe a novel LXR target, the sterol regulatory element-binding protein-1c gene (SREBP-1c), which encodes a membrane-bound ..
  6. pmc LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    B A Laffitte
    Howard Hughes Medical Institute, Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:507-12. 2001
    ..We demonstrate here that the nuclear receptors LXRalpha and LXRbeta and their oxysterol ligands are key regulators of apoE expression in both macrophages and adipose tissue...
  7. pmc Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    S Alberti
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Clin Invest 107:565-73. 2001
    The nuclear oxysterol-receptor paralogues LXRalpha and LXRbeta share a high degree of amino acid identity and bind endogenous oxysterol ligands with similar affinities...
  8. pmc Identification of macrophage liver X receptors as inhibitors of atherosclerosis
    Rajendra K Tangirala
    X Ceptor Therapeutics, 4757 Nexus Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:11896-901. 2002
    Recent studies have identified the liver X receptors (LXR alpha and LXR beta) as important regulators of cholesterol metabolism and transport...
  9. ncbi Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    Sean B Joseph
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Nat Med 9:213-9. 2003
    ..Transcriptional profiling of lipopolysaccharide (LPS)-induced macrophages reveals reciprocal LXR-dependent regulation of genes involved in lipid metabolism and the innate immune response...
  10. ncbi Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling
    Tomohiro Ide
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Mol Endocrinol 17:1255-67. 2003
    ..fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis...
  11. ncbi LXR-dependent gene expression is important for macrophage survival and the innate immune response
    Sean B Joseph
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 119:299-309. 2004
    ..We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses...
  12. ncbi Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions
    J M Frenoux
    Epididyme et Maturation des Gamètes, CNRS UMR 6547 GEEM, Universite Blaise Pascal, 24, avenue des Landais, 63177 Aubiere, France
    J Mol Endocrinol 33:361-75. 2004
    ..In agreement with the observed caput defect in transgenic animals in which both LXRalpha and LXRbeta isoforms were disrupted, we have shown here that both receptors are expressed in caput and cauda epididymides ..
  13. ncbi Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells
    Alexander M Efanov
    Lilly Research Laboratories, Essener Strasse 93, D 22419 Hamburg, Germany
    Diabetes 53:S75-8. 2004
    ..Culture of pancreatic islets or insulin-secreting MIN6 cells with a LXR specific agonist T0901317 caused an increase in glucose-dependent insulin secretion and islet insulin content...
  14. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ..In addition, combined activation of LXR and RXR protected macrophages from apoptosis caused by infection with Bacillus anthracis, Escherichia coli, and ..
  15. ncbi The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis
    Kirsten M Robertson
    Karolinska Institutet, Department of Biosciences at Novum, Huddinge 14157, Sweden
    Endocrinology 146:2519-30. 2005
    ..In the absence of LXRbeta, excessive cholesterol accumulated in the Sertoli cells from 2...
  16. ncbi LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function
    Isabelle Gerin
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 280:23024-31. 2005
    ..We demonstrate here that although LXRalpha and LXRbeta are not required for adipocyte development per se, LXRbeta is required for the increase in adipocyte size that ..
  17. ncbi LXRs regulate the balance between fat storage and oxidation
    Nada Y Kalaany
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell Metab 1:231-44. 2005
    ..Here we show that LXR null mice are defective in hepatic lipid metabolism and are resistant to obesity when challenged with a diet ..
  18. pmc Liver X receptors as integrators of metabolic and inflammatory signaling
    Noam Zelcer
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, California 90055 1662, USA
    J Clin Invest 116:607-14. 2006
    ..Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis ..
  19. ncbi Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels
    Heike Zitzer
    Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
    Endocrinology 147:3898-905. 2006
    Liver X receptors (LXRalpha and LXRbeta) regulate glucose and lipid metabolism. Pancreatic beta-cells and INS-1E insulinoma cells express only the LXRbeta isoform...
  20. ncbi Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus
    Kevin Mouzat
    UMR CNRS 6547, LXRs, Oxysterols, and Steroidogenic Tissues, and Research Center for Human Nutrition, 63177 Aubiere, France
    J Biol Chem 282:4693-701. 2007
    ..Here we show that nuclear receptor for oxysterols LXRbeta prevents accumulation of cholesteryl esters in mouse myometrium by controlling expression of genes involved in ..
  21. ncbi Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility
    David H Volle
    Physiologie Comparée et Endocrinologie Moléculaire, Unite Mixte de Recherche, Centre National de la Recherche Scientifique CNRS 6547, 63177 Aubiere Cedex, France
    Mol Endocrinol 21:1014-27. 2007
    Oxysterol nuclear receptors liver X receptor (LXR)alpha and LXRbeta are known to regulate lipid homeostasis in cells exposed to high amounts of cholesterol and/or fatty acids...
  22. ncbi Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells
    Sung Sik Choe
    Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Sillim dong, Kwanak gu, Seoul, Korea
    Diabetes 56:1534-43. 2007
    Liver X receptor (LXR)alpha and LXRbeta play important roles in fatty acid metabolism and cholesterol homeostasis...
  23. pmc Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE
    Michelle N Bradley
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California 90095 1662, USA
    J Clin Invest 117:2337-46. 2007
    ..The phenotype of these mice suggests that the level of LXR pathway activation in macrophages achieved by LXRbeta and endogenous ligand is unable to maintain homeostasis in the setting of hypercholesterolemia...
  24. pmc Androgen deprivation by activating the liver X receptor
    Jung Hoon Lee
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Endocrinology 149:3778-88. 2008
    ..Genetic or pharmacological activation of the liver X receptor (LXR) in vivo lowered androgenic activity by inducing the hydroxysteroid sulfotransferase 2A1, an enzyme essential for ..
  25. pmc LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    Steven J Bensinger
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90049, USA
    Cell 134:97-111. 2008
    ..Ligation of LXR during T cell activation inhibits mitogen-driven expansion, whereas loss of LXRbeta confers a proliferative advantage...
  26. pmc Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression
    Chiara Gabbi
    Department of Biosciences and Nutrition, Clinical Research Center, Karolinska Institutet, Novum, S 141 86, Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:15052-7. 2008
    ..In LXRbeta(-/-) mice on a normal diet, there is a reduction in size of perigonadal fat pad and, on high-fat diet there is ..
  27. doi Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
    Z X Meng
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Clinical Diabetes Centre of Jiangsu Province, Nanjing Medical University, Nanjing, People s Republic of China
    Diabetologia 52:125-35. 2009
    ..However, the roles of LXRs in pancreatic beta cells have not been fully established. The aim of this study was to investigate the effects of LXRs on pancreatic beta cell proliferation...
  28. pmc Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice
    Hyun Jin Kim
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum S 14186, Sweden
    Proc Natl Acad Sci U S A 106:558-63. 2009
    With specific liver X receptor alpha and beta (LXRalpha and LXRbeta) antibodies, we found that LXRalpha is strongly expressed in the luminal and basal cells of prostatic epithelium...
  29. doi Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c
    Yan Qin
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    Biochim Biophys Acta 1791:140-7. 2009
    ..LXRalpha and LXRbeta play different roles in maintenance of basal expression of Elovl5...
  30. pmc LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner
    Aurélia Ouvrier
    Universite Blaise Pascal, Unité Mixte de Recherche GReD Centre National de la Recherche Scientifique 6247, INSERM U931, 63177 Aubiere, Cedex, France
    J Lipid Res 50:1766-75. 2009
    ..LXRs), the nuclear receptors for oxysterols, are of major importance in intracellular cholesterol homeostasis, and LXR(-/-)-deficient male mice have already been shown to have reduced fertility at an age of 5 months and complete ..
  31. pmc Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
    Jihong Xu
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Leukoc Biol 86:401-9. 2009
    ..Previously, we and others demonstrated that LXR agonists suppressed the activation of primary glial cells and blocked the development of EAE...
  32. pmc Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
    Hannelie Korf
    Laboratory of Mycobacterial Immunology, Scientific Institute of Public Health, Brussels, Belgium
    J Clin Invest 119:1626-37. 2009
    ..Furthermore, mice deficient in both LXR isoforms, LXRalpha and LXRbeta (Lxra-/-Lxrb-/- mice), were more susceptible to infection, developing higher bacterial burdens and an increase in ..
  33. pmc LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    Noam Zelcer
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 325:100-4. 2009
    ..Here we show that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeostasis, not only through promotion of cholesterol efflux but also through ..
  34. pmc Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    Noelia A-Gonzalez
    Immune Signaling Laboratory, Department of Biochemistry and Molecular Biology, School of Medicine, University of Las Palmas, ULPGC, 35016 Las Palmas, Spain
    Immunity 31:245-58. 2009
    ..We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance...
  35. pmc Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
    Eric D Bischoff
    Exelixis, Inc, San Diego, CA, USA
    J Lipid Res 51:900-6. 2010
    The liver X receptors LXRalpha and LXRbeta play critical roles in maintaining lipid homeostasis by functioning as transcription factors that regulate genetic networks controlling the transport, catabolism, and excretion of cholesterol...
  36. pmc LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
    Rucha Patel
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 121:431-41. 2011
    ..Here, we show LXRβ is required to mediate many of the negative side effects of glucocorticoids...
  37. pmc Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
    Cynthia Hong
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Lipid Res 52:531-9. 2011
    ..One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects...
  38. pmc Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
    Guoliang Cui
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of CAS, Chinese Academy of Sciences, Shanghai, China
    J Clin Invest 121:658-70. 2011
    ..We report here that ectopic expression of liver X receptor (LXR) inhibits Th17 polarization of mouse CD4+ T cells, while LXR deficiency promotes Th17 differentiation in vitro...
  39. pmc Coordinate regulation of neutrophil homeostasis by liver X receptors in mice
    Cynthia Hong
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    J Clin Invest 122:337-47. 2012
    ..Using gain- and loss-of-function models, we found that LXR signaling regulated the efficient clearance of senescent neutrophils by peripheral tissue APCs in a Mer-dependent ..
  40. doi Lxrα regulates the androgen response in prostate epithelium
    Emilie Viennois
    Department of Génétique Reproduction et Développement, Clermont Universite, F 63000 Clermont Ferrand, France
    Endocrinology 153:3211-23. 2012
    ..We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of ..
  41. ncbi Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 310:589-93. 2003
    ..In this study we show that LXRalpha and LXRbeta are more expressed in brown adipose tissue and subcutaneous white adipose tissue than visceral (gonadal) adipose ..
  42. pmc Liver X receptors regulate adrenal cholesterol balance
    Carolyn L Cummins
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    J Clin Invest 116:1902-12. 2006
    ..Here, we show the role of the liver X receptors (LXRalpha and LXRbeta) in preventing accumulation of free cholesterol in mouse adrenal glands by controlling expression of genes ..
  43. pmc Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells
    Bénédicte Mascrez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO Rep 5:285-90. 2004
    ..homeostasis in SCs does not require PPARalpha and beta, but depends upon the TIF2 coactivator and RXRbeta/LXRbeta heterodimers, in which RXRbeta AF-2 is transcriptionally active...
  44. ncbi Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
    Taira Wada
    Center for Pharmacogenetics, 633 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pharmacol 73:891-9. 2008
    ..The mutual suppression between RORalpha and LXR was supported by the in vivo observation that loss of RORalpha increased the expression of selected LXR target ..
  45. pmc Differential anti-atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317
    Dacheng Peng
    Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Atherosclerosis 203:59-66. 2009
    ..In this study, we administered orally the LXR agonist T0901317 to male LDLR-/- mice fed a Western diet...
  46. doi Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis
    Darren L Asquith
    Glasgow Biomedical Research Center, Division of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow, UK
    Arthritis Rheum 60:2655-65. 2009
    ..This study was therefore undertaken to explore the biologic mechanisms of LXRs in vivo and in vitro in an experimental inflammatory arthritis model...
  47. pmc Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis
    Balachandar Nedumaran
    Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500 757, Korea
    J Biol Chem 285:9221-32. 2010
    ..Overall, this study suggests that DAX-1, a novel corepressor of LXRalpha, functions as a negative regulator of lipogenic enzyme gene expression in liver...
  48. pmc Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation
    Krisztina Köröskényi
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen H 4012, Hungary
    J Immunol 186:7144-55. 2011
    ..Altogether, our data indicate that adenosine is one of the soluble mediators released by macrophages that mediate engulfment-dependent apoptotic cell suppression of inflammation...
  49. pmc Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex
    Xin Jie Tan
    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 109:7493-8. 2012
    ..Recent studies have implicated liver X receptor β (LXRβ) in key neurodevelopmental processes and neurodegenerative diseases...
  50. doi A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα
    Simon Ducheix
    INRA, UMR1331, Toxalim, Research Centre in Food Toxicology, Universite de Toulouse, Toulouse, France
    Biochimie 95:556-67. 2013
    ..As expected, T0901317 and fenofibrate induce expression of genes involved LXR-dependent and PPARα-dependent lipogenic responses...
  51. doi Oxysterol-induced soluble endoglin release and its involvement in hypertension
    Ana C Valbuena-Diez
    Centro de Investigaciones Biologicas, C Ramiro de Maeztu 9, Madrid 28040, Spain
    Circulation 126:2612-24. 2012
    ..Here, we investigated the effects of hypoxia and the downstream pathways in the release of sEng...
  52. pmc Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes
    Cédric Rébé
    Centre de Recherche Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 866, Universite de Bourgogne, Dijon, France
    PLoS ONE 7:e48738. 2012
    Liver X receptor (LXR) α and LXR β (NR1H3 and NR1H2) are oxysterol-activated nuclear receptors involved in the control of major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation and innate immunity...
  53. doi Identification of interferon-γ as a new molecular target of liver X receptor
    Qixue Wang
    College of Life Sciences, Nankai University, Tianjin 300071, China
    Biochem J 459:345-54. 2014
    b>LXR (liver X receptor) is a ligand-activated transcription factor and plays an important role in regulation of lipid homoeostasis and inflammation...
  54. pmc Cholestenoic acids regulate motor neuron survival via liver X receptors
    Spyridon Theofilopoulos
    J Clin Invest 124:4829-42. 2014
    ..While 3β,7α-dihydroxycholest-5-en-26-oic acid (3β,7α-diHCA) promoted motor neuron survival in an LXR-dependent manner, 3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) promoted maturation of precursors into ..
  55. doi Enolase is regulated by Liver X Receptors
    Hugues de Boussac
    Université Clermont Auvergne, Universite Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F63000 Clermont Ferrand, France CNRS, UMR 6293, GReD, F 63177 Aubiere, France INSERM, UMR 1103, GReD, F 63177 Aubiere, France Centre de Recherche en Nutrition Humaine d Auvergne, F 63000 Clermont Ferrand, France
    Steroids 99:266-71. 2015
    ..Here, we describe that J774 macrophages treated with LXR agonists exhibit reduced Enolase transcript and protein abundance...
  56. pmc Liver X receptor agonist modulation of cholesterol efflux in mice with intestine-specific deletion of microsomal triglyceride transfer protein
    Yan Xie
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 32:1624-31. 2012
    ..of intestinal Niemann-Pick C1-like 1 and ATP-binding cassette protein A1 are required for liver X receptor (LXR) agonist-mediated increases in high-density lipoprotein biogenesis...
  57. pmc Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition
    Hiroyuki Mori
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
    J Clin Invest 122:2405-16. 2012
    ..Thus, our findings support a model of adipogenesis in which SFRP5 inhibits WNT signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity...
  58. pmc Myelin-derived lipids modulate macrophage activity by liver X receptor activation
    Jeroen F J Bogie
    Hasselt University Transnational University Limburg, Biomedical Research Institute, School of Life Sciences, Diepenbeek, Belgium
    PLoS ONE 7:e44998. 2012
    ..Our data show that myelin modulates the phenotype of macrophages by nuclear receptor activation, which may subsequently affect lesion progression in demyelinating diseases such as multiple sclerosis...
  59. doi Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages
    Kirsten M Robertson Remen
    Dept of Biosciences and Nutrition at NOVUM, Huddinge, Sweden
    J Leukoc Biol 93:71-82. 2013
    ..The LXRα and -β are important modulators of inflammatory signaling and can potently inhibit RANKL-induced osteoclast ..
  60. pmc Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance
    Simon W Beaven
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Cell Metab 18:106-17. 2013
    ..We show that LXRs modulate key aspects of the metabolic syndrome in mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese but show reduced hepatic steatosis and improved insulin sensitivity ..
  61. ncbi Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors
    W Seol
    Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Mol Endocrinol 9:72-85. 1995
    ..Of four additional RXR-interacting proteins (RIPs) selected for further study two, RIP14 and RIP15, are previously unidentified orphan members of the nuclear receptor superfamily...
  62. ncbi Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis
    Kari Anne Risan Tobin
    Institute for Nutrition Research and Institute of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 277:10691-7. 2002
    ..Furthermore, deletion of both the LXRalpha and LXRbeta genes (double knockout) in mice markedly suppressed insulin-mediated induction of an entire class of enzymes ..
  63. ncbi BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
    Peter A Edwards
    Departments of Biological Chemistry and Medicine, CHS 33 257, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Lipid Res 43:2-12. 2002
    ..three years there have been a plethora of publications on the liver X-activated receptors (LXRalpha, NR1H3, and LXRbeta, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role ..
  64. ncbi Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis
    Laszlo G Komuves
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 118:25-34. 2002
    ..The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation...
  65. ncbi Accumulation of foam cells in liver X receptor-deficient mice
    Gertrud U Schuster
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    Circulation 106:1147-53. 2002
    ..The present study aimed to elucidate the physiological relevance of both LXRs with regard to lipid metabolism and macrophage cholesterol efflux...
  66. pmc Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus
    Oreda Boussadia
    Nucleis, Parc Technologique des Capucins, 49033 Angers, France
    J Virol 77:3353-9. 2003
    ..b>Unr, a cytoplasmic RNA-binding protein that contains five cold-shock domains and is encoded by the gene upstream of N-..
  67. ncbi The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
    Mathias Farnegardh
    Karo Bio AB, Novum, Karolinska Institute, Huddinge University Hosptial, Sweden
    J Biol Chem 278:38821-8. 2003
    The structures of the liver X receptor LXRbeta (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 A, respectively...
  68. ncbi Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha
    Knut Tomas Dalen
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 278:48283-91. 2003
    ..The expression of GLUT4 in WAT is induced by a potent LXR agonist in wild type, LXR alpha-/-, and LXR beta-/- mice but not in LXR alpha-/-beta-/- mice, demonstrating that both LXRs are able to mediate ligand activated ..
  69. ncbi Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors
    Robert Walczak
    Howard Hughes Medical Institute, University of California, Los Angeles, California 90095 1662, USA
    J Biol Chem 279:9905-11. 2004
    ..Both LXRalpha and LXRbeta transactivated the VEGF promoter in transient transfection assays...
  70. ncbi Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes
    David H Volle
    Physiologie Comparée et Endocrinologie Moléculaire, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 6547 Université Blaise Pascal, 24 avenue des Landais, 63177 Aubiere Cedex, France
    Mol Endocrinol 18:888-98. 2004
    ..AKR1-B7 (aldo-keto reductase 1-B7) is expressed in LXR target tissues such as intestine, and because of its known role in detoxifying lipid peroxides, we investigated ..
  71. ncbi Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue
    Stine Marie Ulven
    Department of Nutrition, University of Oslo, N 0316 Oslo, Norway
    J Lipid Res 45:2052-62. 2004
    ..Using different LXR-deficient mice, we demonstrate that the basal expression level of LXRalpha is increased in LXRbeta(-/-) mice, whereas the basal expression level of LXRbeta is unchanged in LXRalpha(-/-) mice...
  72. ncbi Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development
    Geoffroy Marceau
    ARDEMO, Universite d Auvergne, Clermont Ferrand, France
    Anat Rec A Discov Mol Cell Evol Biol 283:175-81. 2005
    Ontogenesis and localization expression of genes encoding for the nuclear receptors for oxysterols (lxralpha and lxrbeta) were investigated in human and mouse placenta during gestation...
  73. ncbi Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype
    Erik G Lund
    Department of Cardiovascular Diseases, Merck Research Laboratories, Merck and Co, Inc, RY80W 250, P O Box 2000, Rahway, NJ 07065, United States
    Biochem Pharmacol 71:453-63. 2006
    Liver X receptor (LXR) alpha and LXRbeta are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription of genes that control cholesterol efflux and fatty acid biosynthesis...
  74. ncbi Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting
    Elaine M Quinet
    Department of Cardiovascular Metabolic Diseases, Wyeth Research, 500 Arcola Road, RN2229, Collegeville, PA 19426, USA
    Mol Pharmacol 70:1340-9. 2006
    The nuclear receptors liver X receptor (LXR) LXRalpha and LXRbeta are differentially expressed ligand-activated transcription factors that induce genes controlling cholesterol homeostasis and lipogenesis...
  75. pmc Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma
    Serena Ghisletti
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 25:57-70. 2007
    ..These studies define parallel but functionally distinct pathways that are utilized by PPARgamma and LXRs to differentially regulate complex programs of gene expression that control immunity and homeostasis...
  76. pmc Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
    Noam Zelcer
    Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:10601-6. 2007
    ..Genetic loss of either Lxralpha or Lxrbeta in APP/PS1 transgenic mice results in increased amyloid plaque load...
  77. ncbi Genetic variations and treatments that affect the lifespan of the NPC1 mouse
    Benny Liu
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75390 9151, USA
    J Lipid Res 49:663-9. 2008
    ..by many factors, including differences in strain background, other inactivating gene mutations (Siat9 and lxrbeta), and administration of agents such as LXR agonists and, particularly, cyclodextrin...
  78. pmc ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
    Pierre Damien Denechaud
    Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    J Clin Invest 118:956-64. 2008
    ..Using an LXR agonist in wild-type mice, we found that LXR stimulation did not promote ChREBP phosphorylation or nuclear ..
  79. pmc Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow
    Chaitra Marathe
    Howard Hughes Medical Institute, Molecular Biology Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:214-24. 2009
    Macrophage lipid metabolism and inflammatory responses are both regulated by the nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic disease progression suggest that PPAR and LXR signaling may alter ..
  80. pmc Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation
    Shuang Chen
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
    J Immunol 181:7186-93. 2008
    ..In some experiments, the synthetic LXR agonist GW3965 was added to macrophages infected with C. pneumoniae in the presence of oxidized LDL...
  81. doi Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes
    N Kumar
    Division of Translational Biology, Endocrine Biology Program, The Hamner Institutes for Health Sciences, Six Davis Drive, Research Triangle Park, NC 27709, USA
    Int J Obes (Lond) 33:519-24. 2009
    ..Here, we investigated the role of LXRs to regulate the expression of the nuclear receptor NOR-1 (neuron-derived orphan receptor-1) in adipocytes...
  82. pmc Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice
    Kevin Mouzat
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique 6247, Clermont Universite, Centre de Recherche en Nutrition Humaine d Auvergne, 63177 Aubiere Cedex, France
    Endocrinology 150:3369-75. 2009
    ..Here we show that liver X receptor (LXR)-alpha and LXR-beta deficient mice present many clinical and biological signs of ovarian hyperstimulation syndrome: ..
  83. doi Liver X receptors control IgE expression in B cells
    Guido Heine
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 182:5276-82. 2009
    ..In this study, we show constitutive expression of the nuclear liver X receptor (LXR)alpha and LXRbeta in peripheral human B cells...
  84. pmc Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling
    Sijie Wu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 435, 1675 University Boulevard, Birmingham, AL 35242, USA
    Cardiovasc Res 84:119-26. 2009
    ..Several members of nuclear receptor superfamily, including liver X receptors (LXRalpha and LXRbeta), have been shown to suppress inflammatory responses, but little is known about their effects in cardiomyocytes.
  85. pmc Negative regulation of Hedgehog signaling by liver X receptors
    Woo Kyun Kim
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Mol Endocrinol 23:1532-43. 2009
    ..Activation of LXR by specific pharmacological ligands, TO901317 and GW3965, inhibited the responses of pluripotent bone marrow ..
  86. doi Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice
    Marion Korach-Andre
    Dept of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Am J Physiol Endocrinol Metab 298:E167-78. 2010
    The two liver X receptors (LXRs), LXRalpha and LXRbeta, are transcriptional regulators of cholesterol, lipid, and glucose metabolism and are both activated by oxysterols...
  87. pmc REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis
    Gwendal Le Martelot
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, Geneva, Switzerland
    PLoS Biol 7:e1000181. 2009
    ..Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols...
  88. doi A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 390:1260-5. 2009
    We report the isolation and functional characterization of a novel transcriptional co-activator, termed LXRBSV. LXRBSV is an alternative splicing variant of liver X receptor (LXR)-beta LXRBSV has an intronic sequence between exons 2 and 3 ..
  89. doi LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux
    N P Hessvik
    Dept of Pharmaceutical Biosciences, Univ of Oslo, Norway
    Am J Physiol Endocrinol Metab 298:E602-13. 2010
    ..However, their role in skeletal muscle is poorly studied and the functional role of each of the LXRalpha and LXRbeta subtypes in skeletal muscle is at present unknown...
  90. pmc LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model
    Ning Li
    Pfizer BioTherapeutics Research, Cambridge, MA 02140, USA
    Proc Natl Acad Sci U S A 107:3734-9. 2010
    ..receptor family transcription factors Liver X Receptors (LXRalpha and -beta) are expressed in cartilage, with LXRbeta being the predominant isoform...
  91. pmc ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
    James J Donkin
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 285:34144-54. 2010
    ..Agonists of liver X receptors (LXR), including GW3965, induce transcription of several genes including ABCA1 and apoE, and reduce Aβ levels and ..
  92. pmc Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity
    Marion Korach-Andre
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, 14183 Huddinge, Sweden
    Proc Natl Acad Sci U S A 108:403-8. 2011
    ..The role of LXRs in the regulation of energy homeostasis remains unclear, however. Female WT, LXRαβ(-/-), LXRα(-/-), and LXRβ(-/-) mice were fed with either a normal diet (ND) or a high-carbohydrate diet (HCD) ..
  93. doi Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
    Marion Korach-Andre
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institutet, Lipid Laboratory, Huddinge, Sweden
    Am J Physiol Endocrinol Metab 301:E210-22. 2011
    ..Recently, LXRs have been proposed as a glucose sensor affecting LXR-dependent gene expression...
  94. ncbi Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2
    S K Lee
    Center for Ligand and Transcription, Department of Biology, Chonnam National University, Kwangju 500 757, Korea
    Mol Endocrinol 15:241-54. 2001
    ..From these results, we concluded that ASC-2 directly binds to nuclear receptors and recruits CBP to mediate the nuclear receptor transactivation in vivo...
  95. ncbi Expression of the liver X receptor alpha and beta in embryonic and adult mice
    Jean Sebastien Annicotte
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, Illkirch, France
    Anat Rec A Discov Mol Cell Evol Biol 277:312-6. 2004
    ..LXRalpha and LXRbeta are detected in the liver starting at 11.5 days postcoitum...
  96. pmc Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    Mitsuhiro Watanabe
    Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    J Clin Invest 113:1408-18. 2004
    ..expression by either natural or synthetic farnesoid X receptor (FXR) agonists on both SHP and LXR alpha and LXR beta. These results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should ..
  97. ncbi Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    J Mol Endocrinol 33:609-22. 2004
    The liver X receptors alpha and beta (LXRalpha and LXRbeta ) are members of the nuclear receptor superfamily of proteins which are highly expressed in metabolically active tissues...
  98. pmc Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice
    Sandra Andersson
    Department of Medical Nutrition, Karolinska Institute, Novum, 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 102:3857-62. 2005
    ..Because the LXRs are important for cholesterol and lipid metabolism, we speculate that absence of LXRbeta leads to pathological accumulation of sterols and lipids that may themselves be neurotoxic or may modulate ..
  99. pmc Liver X receptors alpha and beta regulate renin expression in vivo
    Fulvio Morello
    Duke University Medical Center, Durham, NC 27710, USA
    J Clin Invest 115:1913-22. 2005
    ..In the present study, we investigated the role of liver X receptor alpha (LXR(alpha)) and LXR(beta) in the regulation of renin...
  100. ncbi Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
    E Rigamonti
    UR 545 INSERM, Institut Pasteur de Lille and Université de Lille 2, France
    Circ Res 97:682-9. 2005
    ..Here we investigated the influence of LXR activation on intracellular cholesterol trafficking in primary human macrophages...
  101. ncbi Improved metabolic control by depletion of Liver X Receptors in mice
    Gertrud U Schuster
    Department of Biosciences and Nutrition, Karolinska University Hospital, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Biochem Biophys Res Commun 348:176-82. 2006
    Liver X Receptors (LXRs) coordinate the regulation of lipid and carbohydrate metabolism and insulin signaling. LXR-ligands lower plasma glucose in hyperglycemic rodents and have consequently been proposed as anti-diabetic agents...

Research Grants7

  1. Phase II UDP-glucuronosyltransferases by PXR
    Wen Xie; Fiscal Year: 2007
    ..These include bilirubin and hormonal homeostasis, drug metabolism, and chemical carcinogenesis. ..
  2. PXR Controlled Bile Acid Detoxification in Colon Cancer
    Wen Xie; Fiscal Year: 2008
    ..It is anticipated that the development of selective PXR agonists may represent a novel strategy to eliminate toxic bile acids and to prevent colon cancer. ..
  3. The Hepatoprotective Role of the Orphan Nuclear Receptor LXR
    Wen Xie; Fiscal Year: 2010
    ..Promoter analysis suggested that SULT2A9, GST M1, and MRP2 are transcriptional targets of LXR. We also showed that the VP-LXR1 transgenic mice were more resistant to APAP hepatotoxicity...
  4. Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
    Wen Xie; Fiscal Year: 2011
    ..The most notable is the induction of the Phase II sulfotransferases (SULTs) in the VP-LXRa mice and LXR agonist-treated wild type mice...
  5. Function and Signaling Mechanisms of Leptin Receptors
    Joyce Repa; Fiscal Year: 2005
    ..A better understanding of the signal transduction pathway used by leptin may reveal novel strategies to enhance or inhibit leptin's biological activities for therapeutic purposes. ..
  6. Recombinant Listeria monocytogenes expressing ALS3: a vaccine against candidiasis
    Kevin Bruhn; Fiscal Year: 2008
    ..Successful completion of these studies will enable development of the vaccine in a future Phase II proposal. [unreadable] [unreadable] [unreadable]..
  7. Identification of Genes Activated by Bile Acids
    Peter Edwards; Fiscal Year: 2009
    ..In addition, these studies will elucidate the role of FXR in glucose, steroid and drug metabolism and in resistance to endotoxin. ..