Nqo1

Summary

Gene Symbol: Nqo1
Description: NAD(P)H dehydrogenase, quinone 1
Alias: AV001255, Dia4, Dtd, Nmo-1, Nmo1, Nmor1, Ox-1, Ox1, Qr1, NAD(P)H dehydrogenase [quinone] 1, DT-diaphorase, NAD(P)H dehydrogenase (quinone), NAD(P)H menadione oxidoreductase 1, dioxin inducible, NAD(P)H:quinone oxidoreductase 1, azoreductase, diaphorase 4 (NADH/NADPH), menadione reductase, phylloquinone reductase, quinone reductase 1
Species: mouse

Top Publications

  1. pmc Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
    Cell Stress Chaperones 11:356-63. 2006
  2. pmc Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1
    Joshua P Gray
    United States Coast Guard Academy, New London, Connecticut, USA
    Am J Physiol Endocrinol Metab 301:E113-21. 2011
  3. doi Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
    Henna Kaisa Jyrkkänen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, Finland
    Circ Res 103:e1-9. 2008
  4. pmc Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
    Tae Yamamoto
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Biol 28:2758-70. 2008
  5. pmc Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice
    Jung Hwan Hwang
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
    Diabetes 58:965-74. 2009
  6. ncbi NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53
    Xing Gong
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 67:5380-8. 2007
  7. ncbi Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, M D Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    J Biol Chem 281:19798-808. 2006
  8. pmc Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer
    B A Patrick
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncogene 30:1098-107. 2011
  9. ncbi NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps
    Fredrik Gussing
    Department of Molecular Biology, Umea University, Umea, SE901 87, Sweden
    Eur J Neurosci 19:2511-8. 2004
  10. ncbi Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity
    V Radjendirane
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 273:7382-9. 1998

Research Grants

Scientific Experts

  • Yung Hyun Choi
  • Keiji Tabuchi
  • P E Phelps
  • Frank J Gonzalez
  • G S Gerhard
  • Judith Voynow
  • Guo Dong Zhou
  • JANET STRINGER
  • R Ruffoli
  • Alison C Brewer
  • Weisong Zhou
  • Craig D Fisher
  • Anil K Jaiswal
  • Jung Hwan Hwang
  • Karim Iskander
  • Minho Shong
  • Chul Ho Lee
  • Seung Taek Nam
  • Gil Tae Gang
  • A K Jaiswal
  • Yong Hoon Kim
  • Erin N Potts-Kant
  • B A Patrick
  • Christophe Noll
  • Gad Asher
  • Hyo Kyun Chung
  • Jung Ran Noh
  • Masayuki Yamamoto
  • W Michael Foster
  • Delwin J Long
  • Yosef Shaul
  • D J Long
  • Alexandra M Miller
  • Roberto Barrios
  • Amitava Das
  • Young Jung Kim
  • Hozumi Motohashi
  • Peter Tsvetkov
  • Jae Sam Hwang
  • Ho Kim
  • Dae Hong Kim
  • Ju Young Jung
  • Kyoung Shim Kim
  • H J Kim
  • Dennis R Roop
  • Jun Suzuki
  • Brian O Ingram
  • Nicki A Baker
  • Yaarit Adamovich
  • Apparao B Kummarapurugu
  • Andrew J Ghio
  • Bernard M Fischer
  • Emilie E Vomhof-DeKrey
  • Brad A Patrick
  • Junkang Xu
  • Jeongho Kwon
  • Aaron J Huebner
  • Robert D Bongard
  • Marisa L Meyer
  • Nathalie Janel
  • Jean Maurice Delabar
  • Jean Louis Paul
  • Clémentine Ripoll
  • Joshua P Gray
  • Min Chen
  • Xinghua Lin
  • Jin Hyung Cho
  • Jun Shen
  • Sabine Werner
  • Keiko Taguchi
  • Lydia R Maurer
  • Tae Hwan Kwak
  • Amandine Alard
  • Charles A Greer
  • Arie S Mobley
  • Haruki Takeuchi
  • Amos Gaikwad
  • Roberto J Barrios
  • Shengli Shi
  • Takafumi Suzuki
  • Kaoru Terai
  • Henna Kaisa Jyrkkänen
  • Cynthia D Duggan
  • Tobias A Beyer
  • Tae Yamamoto
  • Jonathan M Maher
  • Anbu Karani Adikesavan
  • Korry J Hintze
  • Xing Gong
  • Negar Gharavi

Detail Information

Publications95

  1. pmc Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
    Cell Stress Chaperones 11:356-63. 2006
    ..factor-E2-related factor (Nrf2) induces expression of numerous genes including NAD(P)H:quinone oxidoreductase 1 (Nqo1) during periods of oxidative stress...
  2. pmc Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1
    Joshua P Gray
    United States Coast Guard Academy, New London, Connecticut, USA
    Am J Physiol Endocrinol Metab 301:E113-21. 2011
    ..Overexpression of cytosolic NAD(P)H-quinone oxidoreductase (NQO1) increased PMET activity in the presence of 10 mM glucose while inhibition of NQO1 by its inhibitor dicoumarol ..
  3. doi Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
    Henna Kaisa Jyrkkänen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, Finland
    Circ Res 103:e1-9. 2008
    ..mediating the induction of glutamate-cysteine ligase modifier subunit (GCLM) and NAD(P)H quinone oxidoreductase-1 (NQO1) by oxPAPC in human endothelial cells, whereas the contribution to the induction of heme oxygenase-1 was less ..
  4. pmc Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
    Tae Yamamoto
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Biol 28:2758-70. 2008
    ..These results demonstrate critical roles of the cysteine residues in vivo in maintaining Keap1 function, such that Nrf2 is repressed under quiescent conditions and active in response to oxidants/electrophiles...
  5. pmc Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice
    Jung Hwan Hwang
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
    Diabetes 58:965-74. 2009
    ..We tried to determine whether pharmacological stimulation of NADH oxidation provides therapeutic effects in rodent models of metabolic syndrome...
  6. ncbi NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53
    Xing Gong
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 67:5380-8. 2007
    ..The cytosolic quinone oxidoreductases [NRH:quinone oxidoreductase 2 (NQO2) and NAD(P)H:quinone oxidoreductase 1 (NQO1)] interacted with p53 and protected p53 against 20S proteasomal degradation...
  7. ncbi Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, M D Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    J Biol Chem 281:19798-808. 2006
    The NAD(P)H:quinone oxidoreductase 1 (NQO1) is a phase II enzyme that reduces and detoxifies quinones and their derivatives...
  8. pmc Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer
    B A Patrick
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncogene 30:1098-107. 2011
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme that protects cells against chemical and radiation-induced oxidative stress and skin cancer...
  9. ncbi NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps
    Fredrik Gussing
    Department of Molecular Biology, Umea University, Umea, SE901 87, Sweden
    Eur J Neurosci 19:2511-8. 2004
    ..We here show that mature neurons in one defined zone selectively express NADPH:quinone oxidoreductase (NQO1), an enzyme that catalyses reduction of quinones...
  10. ncbi Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity
    V Radjendirane
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 273:7382-9. 1998
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress...
  11. pmc Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1
    Gad Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:13125-30. 2002
    ..We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induces p53 and p73 proteasomal degradation...
  12. ncbi NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis
    D J Long
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 60:5913-5. 2000
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity...
  13. ncbi Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 65:2054-8. 2005
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic protein that catalyzes metabolic detoxification of quinones and protects cells against redox cycling and oxidative stress...
  14. doi NQO1-Knockout Mice Are Highly Sensitive to Clostridium Difficile Toxin A-Induced Enteritis
    Seung Taek Nam
    Department of Life Science, College of Natural Science, Daejin University, Pocheon 11159, Republic of Korea
    J Microbiol Biotechnol 26:1446-51. 2016
    ..We previously showed that NADH:quinone oxidoreductase 1 (NQO1) KO (knockout) mice spontaneously display weak gut inflammation and a marked loss of colonic epithelial tight ..
  15. doi Age-related hearing loss and expression of antioxidant enzymes in BDF1 mice
    Keiji Tabuchi
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    Acta Otolaryngol 131:1020-4. 2011
    ..Our data suggest that the changes in expression of antioxidant enzymes may cause age-related hearing loss (AHL)...
  16. pmc Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment
    H J Kim
    Center for Metabolic Function Regulation, Department of Microbiology, Wonkwang University School of Medicine, Jeonbuk, Republic of Korea
    Cell Death Dis 5:e1292. 2014
    ..we show that the induction of cellular NAD(+) levels using β-lapachone (β-Lap), whose intracellular target is NQO1, prevents the toxic effects of cisplatin through the regulation of PARP-1 and SIRT1 activity...
  17. pmc NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation
    Apparao B Kummarapurugu
    Division of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 288:4681-91. 2013
    NADPH:quinone oxidoreductase 1 (NQO1) is recognized as a major susceptibility gene for ozone-induced pulmonary toxicity. In the absence of NQO1 as can occur by genetic mutation, the human airway is protected from harmful effects of ozone...
  18. pmc Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells
    Seung Taek Nam
    Department of Life Science, College of Natural Science, Daejin University, Pocheon 487 711, Korea
    BMB Rep 47:494-9. 2014
    NADH:quinone oxidoreductase 1 (NQO1) is known to be involved in the regulation of energy synthesis and metabolism, and the functional studies of NQO1 have largely focused on metabolic disorders...
  19. doi The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction
    Jung Hwan Hwang
    Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, University of Science and Technology, 125 Gwahak ro, Yuseong Gu, Daejeon, 305 806, South Korea
    Arch Toxicol 89:2159-66. 2015
    ..An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine...
  20. pmc Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes
    Nicki A Baker
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, 40536 0200, USA
    J Nutr Biochem 24:2168-74. 2013
    ..were restored by RSV, which resulted in a concentration-dependent increase in NAD(P)H:quinone oxidoreductase 1 (NQO1), the downstream target of Nrf2 signaling...
  21. doi The cytoprotective effects of ethanol extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK pathway
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Korean Medicine, 52 57, Yangjeong ro, Busanjin, Busan 614 052, Republic of Korea
    Gen Physiol Biophys 35:45-53. 2016
    ..Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2-mediated HO-1 and inducing NQO-1 via the activation of MAPK signaling pathways...
  22. doi Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity
    Young Jung Kim
    Department of Veterinary Medicine and Institute of Veterinary Science, Chungnam National University, Daejeon 305 764, Republic of Korea
    Toxicol Lett 243:22-30. 2016
    ..The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of..
  23. doi Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice
    Gil Tae Gang
    Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Free Radic Biol Med 67:139-49. 2014
    ..Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial tubular damage...
  24. doi Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice
    Brian O Ingram
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U S A
    Biochem J 456:47-54. 2013
    b>NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K...
  25. pmc The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1
    Yaarit Adamovich
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 33:2603-13. 2013
    ..We further demonstrate that PGC-1α degradation is inhibited by NQO1, a 20S gatekeeper protein. NQO1 binds and protects PGC-1α from degradation in an NADH-dependent manner...
  26. doi Neural crest-derived horizontal basal cells as tissue stem cells in the adult olfactory epithelium
    Jun Suzuki
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Neurosci Res 75:112-20. 2013
    ..These results suggest that NCDCs contribute greatly to the adult HBC population and that they are important for the maintenance of the OE...
  27. pmc Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero
    Aaron J Huebner
    Department of Dermatology and Charles C Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Denver, CO 80045, USA
    Dev Cell 23:1238-46. 2012
    ..Our findings reveal that the functions of Nrf2 and the composition of amniotic fluid have coevolved to ensure the formation of a functional barrier...
  28. doi Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism
    Christophe Noll
    Univ Paris Diderot CNRS EAC 4413, Unit of Functional and Adaptive Biology BFA, Case 7104, 75205 Paris Cedex 13, France
    Mol Genet Metab 105:484-8. 2012
    ..hydrolase (SAHH) activity, which depends on the activation of NAD(P)H:quinone oxidoreductase-1 (NQO1)...
  29. pmc NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice
    Erin N Potts-Kant
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 52:705-15. 2012
    ..In models of lung injury, the expression of NAD(P)H:quinone oxidoreductase 1 (NQO1) is upregulated in a manner dependent on Nrf2 and human emphysema is associated with reduced levels of NQO1...
  30. pmc Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade
    Jeongho Kwon
    Sungkyunkwan University School of Medicine and Samsung Biomedical Research Institute, Suwon Si, Kyonggi do 440 746, Korea
    EMBO Rep 13:150-6. 2012
    ..p62 enhanced basal Nrf2 activity, conferring a higher steady-state expression of NAD(P)H dehydrogenase, quinone 1 (Nqo1) to maintain mitochondrial membrane potential and, thereby, restrict excess oxidant generation...
  31. pmc Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer
    B A Patrick
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncogene 31:4362-71. 2012
    Previously, we have shown a role of cytosolic NAD(P)H:quinone oxidoreductase 1 (NQO1) in the stabilization of p63 against 20S proteasomal degradation resulting in thinning of the epithelium and chemical-induced skin cancer (Oncogene (2011)..
  32. pmc Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung
    Robert D Bongard
    Medical College of Wisconsin, Zablocki VAMC, Milwaukee, WI 53295, USA
    Am J Physiol Lung Cell Mol Physiol 302:L949-58. 2012
    ..reduction on passage through the rat pulmonary circulation was catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) and mitochondrial complex I, but that NQO1 genotype was not a factor in CoQ(1) reduction on passage through the ..
  33. pmc NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia
    Marisa L Meyer
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 303:L181-8. 2012
    ..reactive oxygen species, and this response is due in part to upregulation of NADPH quinone oxidoreductase 1 (NQO1) activity...
  34. doi NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes
    Emilie E Vomhof-DeKrey
    Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, ND 58203, USA
    Free Radic Biol Med 53:690-700. 2012
    ..One of the major Nrf2-regulated proteins, NAD(P)H:quinone oxidoreductase 1 (NQO1), is implicated in the development of adipose tissue and obesity...
  35. pmc NAD(P)H:quinone oxidoreductase 1 protects bladder epithelium against painful bladder syndrome in mice
    Brad A Patrick
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Free Radic Biol Med 53:1886-93. 2012
    ..Here we demonstrate that NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)) mice developed in our laboratory represent a new animal model of PBS...
  36. pmc NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative disease
    Junkang Xu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:41608-18. 2012
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that protects cells against radiation and chemical-induced oxidative stress. Disruption of NQO1 gene in mice leads to increased susceptibility to myeloproliferative disease...
  37. pmc Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:7915-22. 2008
    NAD(P)H:quinone oxidoreductase 1 null (NQO1(-/-)) mice exposed to 3 Gy of gamma-radiation showed an increase in neutrophils, bone marrow hypercellularity, and enlarged lymph nodes and spleen...
  38. pmc NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans
    Judith A Voynow
    Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 41:107-13. 2009
    One host susceptibility factor for ozone identified in epidemiologic studies is NAD(P)H quinone oxidoreductase 1 (NQO1)...
  39. doi Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1
    Kaoru Terai
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Academic Health Center, Minneapolis, Minnesota, USA
    Anticancer Drugs 20:901-9. 2009
    NAD(P)H:quinone oxidoreductase (NQO1) has been reported to play an important role in cell death caused by beta-lapachone (beta-lap), 3,4-dihydro-22,2-dimethyl-2H-naphthol[1,22b]pyran-5,6-dione...
  40. pmc The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene
    Shengli Shi
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Carcinogenesis 30:1957-61. 2009
    ..These observations demonstrate that Arnt is required for tumor initiation by B[a]P in this system...
  41. pmc NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome
    Amandine Alard
    INSERM U858, Institut de Médecine Moléculaire de Rangueil I2MR, Département Cancer, Equipe 16, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Biol 30:1097-105. 2010
    ..Here, we show that eIF4GI exists in a complex with NAD(P)H quinone-oxydoreductase 1 (NQO1) in cell extracts...
  42. pmc Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance
    Tobias A Beyer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 27:212-23. 2008
    ..These findings may provide the basis for the development of new strategies to improve regeneration in patients with acute or chronic liver damage...
  43. pmc Genetic analysis of cytoprotective functions supported by graded expression of Keap1
    Keiko Taguchi
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Mol Cell Biol 30:3016-26. 2010
    ..These results support our contention that the benefits of Nrf2 activation in acute toxicity are hormetic and that constitutive Nrf2 activation beyond a certain threshold is rather disadvantageous to long-term survival...
  44. doi Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb
    Haruki Takeuchi
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
    Cell 141:1056-67. 2010
    ..Sequential arrival of OSN axons as well as the graded and complementary expression of Nrp2 and Sema3F by OSNs help to form the topographic order along the D-V axis...
  45. pmc Axon fasciculation in the developing olfactory nerve
    Alexandra M Miller
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neural Dev 5:20. 2010
    ..While regional segregation occurs in the mesenchyme, the final convergence of OR-specific subpopulations does not occur until the axons reach the inner nerve layer of the OB...
  46. pmc Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation
    Arie S Mobley
    Department of Neurosurgery and Neurobiology, Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Neurosci 30:16498-508. 2010
    ..These data support the hypothesis that the outgrowth and coalescence of OSN axons is, at least in part, subject to activity-dependent mechanisms mediated via HCN channels...
  47. doi Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity
    Yong Hoon Kim
    Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong Gu, Daejeon, Republic of Korea
    Cardiovasc Res 91:519-27. 2011
    ..Lapachone (βL), a well-known substrate of NAD(P)H:quinone oxidoreductase (NQO1), increases the cellular NAD(+)/NADH ratio via the activation of NQO1...
  48. doi Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice
    Christophe Noll
    Laboratory of Gene Dysregulation and Differentiation, Univ Paris Diderot CNRS EAC 4413, Unit of Functional and Adaptive Biology BFA, 75205 Paris Cedex 13, France
    Food Chem Toxicol 49:1764-9. 2011
    ..present study, we analyzed the effect of PE supplementation on two phase II XME: NAD(P)H:quinone oxidoreductase (Nqo1) and arylamine-N-acetyltransferase (Nat) family...
  49. pmc Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
    Alison C Brewer
    King s College London British Heart Foundation Centre of Research Excellence, Cardiovascular Division, London, UK
    Free Radic Biol Med 51:205-15. 2011
    ..These data therefore demonstrate that Nox4 can activate the Nrf2-regulated pathway, and suggest a potential role for Nox4 in the regulation of GSH redox in cardiomyocytes...
  50. pmc Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase
    Xinghua Lin
    Department of Physiology, Meharry Medical College, Nashville, TN 37208, USA
    Free Radic Biol Med 51:97-106. 2011
    ..NAD(P)H:quinone oxidoreductase-1 (NQO1) is an enzyme that catalyzes BaP-quinone detoxification...
  51. doi Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity
    Min Chen
    Center for Drug Safety Evaluation and Research, State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Pudong, Shanghai 201203, China
    Toxicol Sci 122:288-96. 2011
    ..Here, we showed that NAD(P)H:quinone oxidoreductase 1 (NQO1) was highly expressed in mouse renal tubular epithelial cells...
  52. doi The pattern of glomerular map formation defines responsiveness to aversive odorants in mice
    Jin Hyung Cho
    Centre for Neuronal Survival, Montreal Neurological Institute, and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurosci 31:7920-6. 2011
    ..Furthermore, these mice show decreased avoidance behavior toward the predator odorant trimethyl-thiazoline. Our results indicate that the pattern of glomerular innervation in the OB is critical for innate behavioral responses in mice...
  53. pmc PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression
    Weisong Zhou
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 301:L615-22. 2011
    ..PGI(2) induction of Nqo 1 provides a possible novel mechanism by which this prostanoid protects against bleomycin-induced mortality and identifies a potential therapeutic target for human ALI...
  54. ncbi Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity
    P Joseph
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Pharmacol 60:207-14. 2000
    b>NQO1-/- mice, along with Chinese hamster ovary (CHO) cells, were used to determine the in vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in cellular protection against quinone cytotoxicity, membrane damage, DNA damage, and ..
  55. pmc Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis
    Craig D Fisher
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel, Tucson, AZ 85721, USA
    Arch Toxicol 82:959-64. 2008
    ..and induction of downstream DME targets Cyp1A1, Cyp2B10, Cyp3A11, Cyp4A14 and NAD(P)H:quinone oxidoreductase 1 (Nqo1), respectively...
  56. ncbi Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity
    Delwin J Long
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:46131-9. 2002
    ..The NQO2-null mice are a model for NQO2 deficiency in humans and can be used to determine the role of this enzyme in sensitivities to toxicity and carcinogenesis...
  57. ncbi Evidence for a cell-specific action of Reelin in the spinal cord
    Patricia E Phelps
    Department of Physiological Science, UCLA, Los Angeles, California 90095 1527, USA
    Dev Biol 244:180-98. 2002
    ..These results suggest that Reelin acts in a cell-specific manner on the migration of cholinergic spinal cord neurons...
  58. ncbi Genetic differences in hepatic lipid peroxidation potential and iron levels in mice
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Mech Ageing Dev 123:167-76. 2002
    ..0006. At least two potentially relevant candidate genes reside close to this chromosomal position. Hepatic lipid peroxidation potential appears to be a strain related trait in mice that is amenable to QTL analysis...
  59. ncbi Ultrastructural localization of the NADPH-diaphorase activity in the Leydig cells of aging mice
    R Ruffoli
    Dipartimento di Morfologia Umana e Biologia Applicata, Facolta di Medicina e Chirurgia, Universita degli Studi di Pisa, Via Roma, 55 56126 Pisa, Italy
    Anat Embryol (Berl) 203:383-91. 2001
    ..We conjecture that the impaired steroidogenesis observed in the testis of aging mammals might, at least in part, depend on the increased nitric oxide production in the Leydig cells...
  60. ncbi Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice
    F J Gonzalez
    National Institutes of Health, National Cancer Institute, Building 37 Room 3E 24, Bethesda, MD 20892, USA
    Mutat Res 477:79-87. 2001
    ..Mice lacking expression of microsomal epoxide hydrolase (mEH) and NADPH-quinone oxidoreductase (NQO1) were also made...
  61. ncbi In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue
    A Gaikwad
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:22559-64. 2001
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that utilizes NAD(P)H as an electron donor, catalyzing the two-electron reduction and detoxification of quinones and their derivatives...
  62. ncbi The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons
    R Sakai
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Neuron 28:819-33. 2000
    ..The results indicate that these Shc family members possess both unique and overlapping functions in regulating neural development and suggest physiological roles for ShcB/ShcC in TrkA signaling...
  63. ncbi Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene- and tissue-specific expression
    D J Long
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
    Gene 252:107-17. 2000
    ..Northern analysis of eight mouse tissues indicated wide variations in the expression of the NQO2 and NQO1 genes...
  64. ncbi Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo
    Krisztian J Kapinya
    Department of Experimental Neurology, Medical Faculty Charité, Humboldt University Berlin, Dorotheenstrasse 94, D 10098 Berlin, Germany
    J Neurochem 84:1028-39. 2003
    A direct involvement of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO1) in neuroprotection has not yet been shown...
  65. pmc Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release
    M Faig
    Departments of Biophysics and Biophysical Chemistry and Pharmacology and Molecular Sciences, Johns Hopkins Medical School, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:3177-82. 2000
    NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles...
  66. ncbi Cloning and heterologous expression of NAD(P)H:quinone reductase of Arabidopsis thaliana, a functional homologue of animal DT-diaphorase
    F Sparla
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Via Irnerio 42, I 40126, Bologna, Italy
    FEBS Lett 463:382-6. 1999
    ..Conversely, in spite of the functional homology, sequence similarity between plant NQR and animal DT-diaphorase was limited and essentially confined to the flavin binding site...
  67. ncbi Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor
    J J Reiners
    Institute of Chemical Toxicology, Wayne State University, Detroit, Michigan 48201, USA
    Mol Carcinog 21:135-46. 1998
    ..Analyses of CYP1A1, CYP1B1, cytosolic aldehyde dehydrogenase class 3, and NAD(P)H:menadione oxidoreductase (NMO1) mRNA content by RT-PCR revealed significant increases in all four mRNAs in the normal tissue adjacent to ..
  68. ncbi Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    Pharmacogenetics 4:341-8. 1994
    ..oxidoreductase [also called NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase; azo dye reductase; DT diaphorase; EC 1.6.99.2]...
  69. ncbi Gene targeting of DT-diaphorase in mouse embryonic stem cells: establishment of null mutant and its mitomycin C-resistance
    T Yoshida
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa
    Biochem Biophys Res Commun 214:701-8. 1995
    ..These mutant cell lines seem to be very useful for investigating the functions of DT-diaphorase including the bioactivation and detoxification of quinone species. The generation of a DT-diaphorase-targeted mouse is under investigation...
  70. pmc Mouse liver NAD(P)H:quinone acceptor oxidoreductase: protein sequence analysis by tandem mass spectrometry, cDNA cloning, expression in Escherichia coli, and enzyme activity analysis
    S Chen
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Protein Sci 3:1296-304. 1994
    ..an amino acid sequence similar to those of the rat and human enzymes, the mouse enzyme has a higher NAD(P)H-menadione reductase activity and is less sensitive to flavones and dicoumarol, 2 known inhibitors of the enzyme...
  71. pmc Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion
    D D Petersen
    Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:6699-703. 1989
    The NAD(P)H:menadione oxidoreductase gene (Nmo-1) codes for a quinone reductase (also called DT diaphorase; EC 1.6.99.2) believed to play a central role in protection against oxidative stress...
  72. ncbi Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice
    S Ruppert
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Genes Dev 6:1430-43. 1992
    ..Mechanisms by which this metabolic defect might bring about alterations in gene expression characteristic of the alf/hsdr-1 deletion phenotype are discussed...
  73. ncbi Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin
    A Puga
    Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    FASEB J 6:777-85. 1992
    ..TCDD, mevinolin markedly increases Cyp1a-1 transcription, CYP1A1 mRNA and protein levels and enzyme activity, and NMO1 mRNA concentrations...
  74. ncbi BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2
    Amitava Das
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Free Radic Biol Med 40:1843-56. 2006
    NAD(P)H/NRH:quinone oxidoreductases (NQO1 and NQO2) protect against oxidative stress and neoplasia. Cross-breeding of NQO1-/- with NQO2-/- mice generated double-knockout (DKO) mice...
  75. pmc Foxg1 is required for development of the vertebrate olfactory system
    Cynthia D Duggan
    Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, and Functional Genomics Laboratory, University of California, Berkeley, California 94720 3200, USA
    J Neurosci 28:5229-39. 2008
    ..Therefore, we identified an evolutionarily conserved requirement for Foxg1 in the development of the vertebrate olfactory system...
  76. ncbi Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse
    K Kumaki
    J Biol Chem 252:157-65. 1977
    ..These experimental data might be useful in the protein activator hypothesis of the Britten-Davidson model for gene regulation...
  77. ncbi Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1
    Korry J Hintze
    Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Biol Chem 282:34365-71. 2007
    ....
  78. ncbi Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide
    Negar Gharavi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Sci 96:2795-807. 2007
    ..receptor (AhR)-regulated genes, such as cytochrome P450 1a1 (Cyp1a1) and NADPH: quinone oxidoreductase 1 (Nqo1) gene expression, yet the mechanisms involved remain unknown...
  79. ncbi NQO1 and NQO2 regulation of humoral immunity and autoimmunity
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:30917-24. 2006
    NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze metabolic reduction of quinones and derivatives...
  80. ncbi Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer
    Xiaoqing He
    Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Biol Chem 281:23620-31. 2006
    ..We analyzed the signaling pathway for induction of detoxification gene NAD(P)H-quinone oxidoreductase (Nqo1) by arsenic...
  81. ncbi Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain
    Tetsuya Abe
    Department of Medical Chemistry, Kansai Medical University, Moriguchi 570 8506, Japan
    Eur J Neurosci 22:1445-54. 2005
    ....
  82. ncbi Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Chem Biol Interact 153:147-57. 2005
    Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic reduction of quinones and its derivatives to protect cells against redox cycling and oxidative stress...
  83. ncbi 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1
    Gad Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 17:645-55. 2005
    ..We describe here an alternative pathway for ODC degradation that is regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). We show that NQO1 binds and stabilizes ODC...
  84. ncbi The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity
    Asa Kolterud
    Department of Molecular Biology, Umea University, Umea, SE901 87, Sweden
    Development 131:5319-26. 2004
    ..do not diversify into subpopulations expressing different OR genes and other region-restricted genes such as Nqo1 and Ncam2...
  85. ncbi Effects of NQO1 deficiency on levels of cyclopurines and other oxidative DNA lesions in liver and kidney of young mice
    Guo Dong Zhou
    Department of Environmental and Occupational Health, School of Rural Public Health, Texas A and M University System, Bryan, TX, USA
    Int J Cancer 112:877-83. 2004
    ..We tested the hypothesis that young mice deficient in NAD(P)H:quinone oxidoreductase 1 (NQO1), an antioxidant enzyme catalyzing the detoxification of quinones and their derivatives, show increased formation ..
  86. ncbi The chemical inducibility of mouse cardiac antioxidants and phase 2 enzymes in vivo
    Zhuoxiao Cao
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Biochem Biophys Res Commun 317:1080-8. 2004
    ..GSH peroxidase (GPx), glutathione reductase (GR), GSH S-transferase (GST), and NAD(P)H:quinone oxidoreductase 1 (NQO1), and investigate the inducibility of the above antioxidants/phase 2 enzymes by the chemoprotectant, 1,2-dithiole-3-..
  87. ncbi Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system
    Janet L Stringer
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Comp Neurol 471:289-97. 2004
    NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes a reductive detoxification that is thought to protect cells against the adverse effects of quinones and related compounds. NQO1 activity is present in all tissues...
  88. pmc P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
    Gad Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 100:15065-70. 2003
    ..The ubiquitin-independent pathway is regulated by NAD(P)H: quinone oxidoreductase 1 (NQO1) that stabilizes p53. The NQO1 inhibitor dicoumarol induces ubiquitin-independent p53 degradation...
  89. ncbi Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper
    Hesham M Korashy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8
    Drug Metab Dispos 34:152-65. 2006
    ..Hepa 1c1c7 cells the expression of the phase II xenobiotic metabolizing enzymes NAD(P)H:quinone oxidoreductase 1 (Nqo1) and glutathione S-transferase subunit Ya (Gst ya) genes, yet the mechanisms involved remain unknown...
  90. ncbi Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
    Nobunao Wakabayashi
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Nat Genet 35:238-45. 2003
    ..Breeding to Nrf2-deficient mice reversed the phenotypic Keap1 deficiencies. These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress...
  91. ncbi Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice
    V Vasiliou
    Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Biochem Biophys Res Commun 233:631-6. 1997
    ..are members of the [Ah] battery and induced by ROM-mediated oxidative stress: NAD(P)H:menadione oxidoreductase (Nmo1) and UDP glucuronosyltransferase-1A6 (Ugt1a6)...
  92. ncbi High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q
    J Becker-Follmann
    Institute of Human Genetics, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Mamm Genome 8:172-7. 1997
    ..1-Mmp2-0.2-Ces1,Es1, Es22-1.2-Mt1,D8Mit15-2.2-Got2, D8Mit11-3.7-Es30-0.3-Es2, Es7-0.9-Ctra1,Lcat-0.3-Cdh1, Cadp, Nmor1, D8Mit12-0.2-Mov34-2.5-Hp,Tat-0.2-Zfp4-1.6-Zfp1,+ ++Ctrb-10.9-e...
  93. pmc Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors
    Jun Shen
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:1006-14. 2010
    The cytosolic quinone oxidoreductases NQO1 and NQO2 protect cells against oxidative stress by detoxifying quinones and preventing redox cycling...
  94. ncbi In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity
    Anbu Karani Adikesavan
    Department of Pharmacology, Baylor College of Medicine and Department of Pathology, Methodist Hospital, Houston, TX, USA
    Cancer Res 67:7966-71. 2007
    NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)), NQO1(+/-) along with NRH:quinone oxidoreductase 2(-/-) (NQO2(-/-)), and wild-type (WT) mice were exposed to five once weekly doses of mitomycin C...
  95. ncbi Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia
    Delwin J Long
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cancer Res 62:3030-6. 2002
    NAD(P)H:quinone oxidoreductase1 (NQO1) is a cytosolic protein that reduces and detoxifies quinones and their derivatives, thus protecting cells against redox cycling and oxidative stress...

Research Grants3

  1. REGULATION OF MUCIN GENE EXPRESSION BY ELASTASE
    Judith Voynow; Fiscal Year: 2003
    ..The ultimate goal is to use information from this project to identify new biologic targets for therapeutic interventions to prevent mucus obstruction in chronic inflammatory airway diseases. ..
  2. MUC4 Mucin and Airway Epithelial Regeneration in COPD
    Judith Voynow; Fiscal Year: 2006
    ..Our ultimate goal is to use information from this project to identify new biologic targets for rational therapies to induce normal airway epithelial proliferation and differentiation following injury. ..
  3. Mucin Gene Regulation by Elastase and Oxidants
    Judith Voynow; Fiscal Year: 2008
    ..this application, we present several key observations linking NE with activation of NAD(P)H:quinone oxidoreductase (NQO1) activation, increased generation of reactive oxygen species, and increased mucin MUC5AC mRNA stabilization due to ..