Nptx2

Summary

Gene Symbol: Nptx2
Description: neuronal pentraxin 2
Alias: Narp, np2, neuronal pentraxin-2, NP-II, neuro activity regulated petaxin, neuronal pentraxin II
Species: mouse

Top Publications

  1. ncbi Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity
    C C Tsui
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 16:2463-78. 1996
  2. pmc Neuronal pentraxins mediate synaptic refinement in the developing visual system
    Lisa Bjartmar
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 26:6269-81. 2006
  3. ncbi Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment
    Gek Ming Sia
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 55:87-102. 2007
  4. pmc Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons
    Kenneth A Pelkey
    Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892, USA Electronic address
    Neuron 85:1257-72. 2015
  5. doi Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia
    Fanny Charbonnier-Beaupel
    Sorbonne Universités, UPMC Univ Paris 06, Paris, France, INSERM, UMR S 1127, ICM, Pitie Salpetriere Hospital, 75013 Paris, France, CNRS, UMR 7225, 75013 Paris, France, Assistance Publique Hopitaux de Paris, Department of Pharmacy, Pitie Salpetriere Hospital, 75013 Paris, France
    J Neurosci 35:96-111. 2015
  6. pmc Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury
    M Miskimon
    Department of Neuroscience, Johns Hopkins University, United States
    J Neuroimmunol 274:86-95. 2014
  7. pmc Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia
    Ashley M Blouin
    Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine, Baltimore, MD 21205, USA Electronic address
    Behav Brain Res 257:178-81. 2013
  8. pmc Obligatory role for the immediate early gene NARP in critical period plasticity
    Yu Gu
    Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA
    Neuron 79:335-46. 2013
  9. pmc Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion
    Bin Xu
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 152:262-75. 2013
  10. pmc Neuronal pentraxins mediate silent synapse conversion in the developing visual system
    Selina M Koch
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:5404-14. 2010

Research Grants

  1. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002

Scientific Experts

  • Alexander W Johnson
  • Kenneth A Pelkey
  • Irving Reti
  • Hans S Crombag
  • Michael C Chang
  • Paul F Worley
  • Fanny Charbonnier-Beaupel
  • M Miskimon
  • Bin Xu
  • Ashley M Blouin
  • Yu Gu
  • Desheng Xu
  • Selina M Koch
  • Paul Worley
  • Erik M Ullian
  • Gek Ming Sia
  • Cheng Xu
  • Bhaskar Saha
  • Richard Cho
  • Lisa Bjartmar
  • P F Worley
  • Matthew During
  • Chuansong Wang
  • Marion Malerbi
  • Jean Antoine Girault
  • Denis Herve
  • Khadija Tahiri
  • Cristina Alcacer
  • Jean Christophe Corvol
  • Wassila Carpentier
  • X Dong
  • S Han
  • R S Petralia
  • J M Baraban
  • M Ringkamp
  • M A Wilson
  • J J Lee
  • Bo Tao
  • Maria Karayiorgou
  • Kimberly L Stark
  • Elizabeth M Quinlan
  • Jongah J Lee
  • Alfredo Kirkwood
  • Joseph A Gogos
  • ShiYong Huang
  • Jay M Baraban
  • Pei Ken Hsu
  • Dani R Smith
  • Joo Min Park
  • David J Linden
  • Heidi L Grabenstatter
  • Thomas P Sutula
  • L L Kirkpatrick
  • Chris J McBain
  • Jean Claude Beique
  • Richard L Huganir
  • Padmanabhan Hari
  • Gavin Rumbaugh
  • Chen Ming Fan
  • Dhananjay Huilgol
  • Shubha Tole
  • Robert C Malenka
  • Ben A Barres
  • David Stellwagen
  • Xiaoqin Liu
  • Andrew D Huberman
  • Weifeng Xu
  • Jennifer Prezioso
  • Caleb C Stokes
  • Sherry Ball
  • Masaru Nakamoto
  • RENE C RENTERIA
  • David Copenhagen
  • Mark S Perin
  • Michael W Susman
  • Barbara Chapman
  • Neal S Peachey
  • C C Tsui
  • D C Dodds
  • M S Perin
  • M M Matzuk
  • C Barnes
  • N A Jenkins
  • N G Copeland
  • D J Gilbert

Detail Information

Publications18

  1. ncbi Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity
    C C Tsui
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 16:2463-78. 1996
    ..We have termed this gene and the encoded protein Narp (from neuronal activity-regulated pentraxin)...
  2. pmc Neuronal pentraxins mediate synaptic refinement in the developing visual system
    Lisa Bjartmar
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 26:6269-81. 2006
    ..Retinas from mice lacking NP1 and NP2 had cholinergically driven waves of activity that occurred at a frequency similar to that of wild-type mice, but ..
  3. ncbi Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment
    Gek Ming Sia
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 55:87-102. 2007
    ..Our results indicate that NP1 and NPR secreted from presynaptic neurons bind to the GluR4 NTD and are critical trans-synaptic factors for GluR4 recruitment to synapses...
  4. pmc Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons
    Kenneth A Pelkey
    Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892, USA Electronic address
    Neuron 85:1257-72. 2015
    ..upregulate GluA4 during the second postnatal week coincident with increases in the AMPAR clustering proteins NPTX2 and NPTXR...
  5. doi Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia
    Fanny Charbonnier-Beaupel
    Sorbonne Universités, UPMC Univ Paris 06, Paris, France, INSERM, UMR S 1127, ICM, Pitie Salpetriere Hospital, 75013 Paris, France, CNRS, UMR 7225, 75013 Paris, France, Assistance Publique Hopitaux de Paris, Department of Pharmacy, Pitie Salpetriere Hospital, 75013 Paris, France
    J Neurosci 35:96-111. 2015
    ..The intersection list identified five genes: FosB, Th, Nptx2, Nedd4l, and Ccrn4l. Nptx2 encodes neuronal pentraxin II (or neuronal activity-regulated pentraxin, Narp), which is involved in the clustering of glutamate ..
  6. pmc Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury
    M Miskimon
    Department of Neuroscience, Johns Hopkins University, United States
    J Neuroimmunol 274:86-95. 2014
    Neuronal activity regulated pentraxin (Narp) is a secreted protein implicated in regulating synaptic plasticity via its association with the extracellular surface of AMPA receptors...
  7. pmc Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia
    Ashley M Blouin
    Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine, Baltimore, MD 21205, USA Electronic address
    Behav Brain Res 257:178-81. 2013
    b>Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus...
  8. pmc Obligatory role for the immediate early gene NARP in critical period plasticity
    Yu Gu
    Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA
    Neuron 79:335-46. 2013
    The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding protein that is specifically enriched at excitatory synapses onto fast-spiking ..
  9. pmc Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion
    Bin Xu
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 152:262-75. 2013
    ..Reduction of miR-185 also has milder age- and region-specific effects on the expression of some Golgi-related genes. Our findings illuminate the contribution of microRNAs in psychiatric disorders and cognitive dysfunction...
  10. pmc Neuronal pentraxins mediate silent synapse conversion in the developing visual system
    Selina M Koch
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:5404-14. 2010
    ..Here we report that the loss of NP1 and NP2 (NP1/2) leads to a dramatic and specific reduction in AMPAR-mediated transmission at developing visual system ..
  11. pmc Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performance
    Alexander W Johnson
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Learn Mem 17:620-6. 2010
    Neuronal activity regulated pentraxin (Narp) is a secreted protein that regulates α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPAR) aggregation and synaptogenesis...
  12. pmc Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
    Michael C Chang
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:1090-7. 2010
    ..The immediate-early gene Narp (neuronal activity-regulated pentraxin) encodes a secreted synaptic protein that can bind to and induce clustering ..
  13. pmc Narp deletion blocks extinction of morphine place preference conditioning
    Hans S Crombag
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 34:857-66. 2009
    ..As Narp is secreted at synaptic sites and binds to the extracellular surface of AMPA receptors, it has been implicated in ..
  14. pmc Activity-dependent secretion of neuronal activity regulated pentraxin from vasopressin neurons into the systemic circulation
    I M Reti
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Neuroscience 151:352-60. 2008
    Neuronal activity regulated pentraxin (Narp) is a secreted, synaptic protein that has been implicated in modulating synaptic transmission. However, it is unclear how Narp secretion is regulated...
  15. pmc A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value
    Alexander W Johnson
    Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 27:13430-5. 2007
    Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which clusters AMPA receptors and regulates excitatory synaptogenesis. Although Narp is selectively enriched in brain, its role in behavior is not known...
  16. ncbi Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1
    Cheng Xu
    Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Mol Endocrinol 21:1234-45. 2007
    ..Together, our results uncover a transcriptional regulation of neuronal migration cues initiated by Sim1 that contribute to the organization of the PVN and SON...
  17. pmc Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract
    Bhaskar Saha
    Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai 400 005, India
    J Neurosci 27:2290-7. 2007
    ..In addition, the expression of Sema6A is aberrantly upregulated. Together, these findings reveal a dual role for Lhx2, in the OB as well as in the lateral telencephalon, for establishing the LOT projection...
  18. ncbi Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2
    L L Kirkpatrick
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 275:17786-92. 2000
    Neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR) are members of a new family of proteins identified through interaction with a presynaptic snake venom toxin taipoxin...

Research Grants1

  1. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
    ..However the molecular mechanisms mediating these changes are unclear. Recent studies have identified Narp as an immediate early gene involved in clustering AMPA receptor subunits at synaptic sites...