Nppc

Summary

Gene Symbol: Nppc
Description: natriuretic peptide type C
Alias: CNP, lbab, C-type natriuretic peptide, natriuretic peptide precursor C, natriuretic peptide precursor type C
Species: mouse

Top Publications

  1. ncbi Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice
    Martin Steinmetz
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Regul Pept 119:31-7. 2004
  2. ncbi C-type natriuretic peptide inhibits growth factor-dependent DNA synthesis in smooth muscle cells
    J G Porter
    Scios Nova, Mountain View, California 94043
    Am J Physiol 263:C1001-6. 1992
  3. ncbi Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
    Takashi Miyazawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 143:3604-10. 2002
  4. ncbi Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice
    Yasato Komatsu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Japan
    J Bone Miner Metab 20:331-6. 2002
  5. ncbi CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Renal Physiol 284:F653-62. 2003
  6. ncbi C-type natriuretic peptide in growth: a new paradigm
    Robert C Olney
    Division of Pediatric Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Growth Horm IGF Res 16:S6-14. 2006
  7. pmc Dwarfism and early death in mice lacking C-type natriuretic peptide
    H Chusho
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:4016-21. 2001
  8. doi Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide
    Eri Kondo
    Departments of Diabetes, Endocrinology, and Nutrition E K, A Y, T F, Y Y, Y U S, N K, M M, N I and Maxillofacial Surgery Kazum N and Medical Innovation Center Kazuw N, Kyoto University Graduate School of Medicine, 606 8507 Kyoto, Japan Health Care Service Center H A, Kyoto Institute of Technology, Matsugasaki Hashikami Cho, 606 8585 Kyoto, Japan and Department of Nephrology M K, Graduate School of Medical Science, Kumamoto University, 860 8556 Kumamoto City, Japan
    Endocrinology 156:2518-29. 2015
  9. doi Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex
    Samantha Richard
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, and Departments of Obstetrics and Gynecology, and Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Biol Reprod 90:137. 2014
  10. pmc Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis
    Hulya Bukulmez
    MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio
    Arthritis Rheumatol 66:78-89. 2014

Research Grants

Scientific Experts

  • Takehito Tsuji
  • I Kishimoto
  • Yukari Ochi
  • Barbara Lewko
  • Robert Olney
  • M Steinmetz
  • Rachel A Heimeier
  • Yan Jiao
  • Pierre Moffatt
  • Andrea R Yoder
  • Chizuru Sogawa
  • Akihiro Yasoda
  • M C Hart
  • Hanga Agoston
  • Kazuwa Nakao
  • Eri Kondo
  • Naohisa Tamura
  • Toshihito Fujii
  • Masako Miura
  • Hiroshi Arai
  • Masashi Mukoyama
  • Megumi Inuzuka
  • Hannes Schmidt
  • Yasato Komatsu
  • Samantha Richard
  • Hulya Bukulmez
  • Arief Thong
  • Yui Yamashita
  • Gohar Ter-Avetisyan
  • Nobuko Yamada-Goto
  • Lipin Loo
  • Tetsuo Kunieda
  • Yorino Sato
  • Chiyo Kiyosu
  • Fritz G Rathjen
  • Goro Katsuura
  • Naotestu Kanamoto
  • Meijia Zhang
  • Tetsuro Yoshioka
  • Takei Kake
  • Zhen Zhao
  • Takashi Miyazawa
  • Anita Woods
  • Y Ogawa
  • John S Lee
  • Jun Su
  • E Dicicco-Bloom
  • N Tamura
  • Kameswaran Surendran
  • Karim Sabrane
  • Yoriko Ueda-Sakane
  • Kazumasa Nakao
  • H Itoh
  • K Nakao
  • Nobuya Inagaki
  • Naotetsu Kanamoto
  • Hideki Chusho
  • Jay M Baltz
  • Yoshihiro Ogawa
  • Angelika Stammler
  • Ralf Middendorff
  • Adriana Ortiz-Lopez
  • Fozia Khan
  • Shunichi Murakami
  • Andrea Mietens
  • Cynthia F Bartels
  • Tariq M Haqqi
  • Caroline Feuerstacke
  • A Inoue
  • Matthew L Warman
  • Abdus Sattar
  • Dieter Muller
  • Hiroyuki Ariyasu
  • Noriko Satoh-Asahara
  • Kiminori Hosoda
  • Toru Kusakabe
  • Ken Ebihara
  • Yuriy M Usachev
  • Kaoru Yamada
  • Leonid P Shutov
  • Aaron D Mickle
  • Ramón A Lorca
  • Aaron J W Hsueh
  • Yuan Cheng
  • F Sugiyama
  • Shimpei Kajita
  • Seido Takae
  • Kazuhiro Kawamura
  • H Chusho
  • Andrew J Shepherd

Detail Information

Publications58

  1. ncbi Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice
    Martin Steinmetz
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Regul Pept 119:31-7. 2004
    This study aimed to characterize the vasorelaxing effects of ANP, BNP and CNP in isolated renal resistance arteries (RRA) from wild-type mice and mice with either systemic (GC-A -/-) or smooth muscle-restricted deletion of GC-A (SMC GC-A ..
  2. ncbi C-type natriuretic peptide inhibits growth factor-dependent DNA synthesis in smooth muscle cells
    J G Porter
    Scios Nova, Mountain View, California 94043
    Am J Physiol 263:C1001-6. 1992
    We have examined the ability of C-type natriuretic peptide (CNP) to interact with guanylate cyclase-coupled natriuretic peptide receptors by measuring its ability to stimulate intracellular guanosine 3',5'-cyclic monophosphate (cGMP) ..
  3. ncbi Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
    Takashi Miyazawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 143:3604-10. 2002
    ..However, given that Prkg2(-/-) mice differ from CNP-deficient mice (Nppc(-/-) mice) in the growth plate histology, which downstream mediator(s) of cGMP play key roles in the process is ..
  4. ncbi Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice
    Yasato Komatsu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Japan
    J Bone Miner Metab 20:331-6. 2002
  5. ncbi CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Renal Physiol 284:F653-62. 2003
    ..CNP inhibits fibroblast activation in vitro and fibrosis in vivo, but endogenous CNP gene (Nppc) expression during tissue fibrosis has not been reported...
  6. ncbi C-type natriuretic peptide in growth: a new paradigm
    Robert C Olney
    Division of Pediatric Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Growth Horm IGF Res 16:S6-14. 2006
    C-type natriuretic peptide (CNP), acting through its receptor, natriuretic peptide receptor-B (NPR-B), plays a critical role in linear growth...
  7. pmc Dwarfism and early death in mice lacking C-type natriuretic peptide
    H Chusho
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:4016-21. 2001
    ..To investigate the physiological significance of CNP in vivo, we generated mice with targeted disruption of CNP (Nppc(-/-) mice). The Nppc(-/-) mice show severe dwarfism as a result of impaired endochondral ossification...
  8. doi Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide
    Eri Kondo
    Departments of Diabetes, Endocrinology, and Nutrition E K, A Y, T F, Y Y, Y U S, N K, M M, N I and Maxillofacial Surgery Kazum N and Medical Innovation Center Kazuw N, Kyoto University Graduate School of Medicine, 606 8507 Kyoto, Japan Health Care Service Center H A, Kyoto Institute of Technology, Matsugasaki Hashikami Cho, 606 8585 Kyoto, Japan and Department of Nephrology M K, Graduate School of Medical Science, Kumamoto University, 860 8556 Kumamoto City, Japan
    Endocrinology 156:2518-29. 2015
    Recent studies have revealed that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. Nevertheless, the effect of CNP on bone turnover has not yet been well studied...
  9. doi Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex
    Samantha Richard
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, and Departments of Obstetrics and Gynecology, and Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Biol Reprod 90:137. 2014
    ..found that cGMP production in cumulus cells depends on NPR2 guanylate cyclase activated by its ligand natriuretic peptide precursor C (NPPC)...
  10. pmc Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis
    Hulya Bukulmez
    MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio
    Arthritis Rheumatol 66:78-89. 2014
    The C-type natriuretic peptide (CNP) signaling pathway is a major contributor to postnatal skeletal growth in humans...
  11. doi Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling
    Gohar Ter-Avetisyan
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Neurosci 34:737-47. 2014
    ..Previously, we have identified a cGMP signaling pathway composed of the ligand C-type natriuretic peptide (CNP), its receptor, the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), and the cGMP-dependent kinase Iα (cGKI..
  12. doi Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells--its relevance for CNP degradation
    Arief Thong
    Institute of Anatomy and Cell Biology, Justus Liebig University Giessen, 35385 Giessen, Germany
    Mol Cell Endocrinol 382:234-43. 2014
    ..C-type natriuretic peptide (CNP) is present in high levels in epididymis and seminal plasma...
  13. doi NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary
    Chiyo Kiyosu
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Reproduction 144:187-93. 2012
    ..Here we report the defects observed in oocytes and follicles of mice homozygous for Nppc(lbab) or Npr2(cn), mutant alleles of Nppc or Npr2 respectively to clarify the exact consequences of lack of NPPC/NPR2 ..
  14. doi Skeletal analysis of the long bone abnormality (lbab/lbab) mouse, a novel chondrodysplastic C-type natriuretic peptide mutant
    Eri Kondo
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Calcif Tissue Int 90:307-18. 2012
    ..Recent studies revealed that the phenotype is caused by a spontaneous mutation in the Nppc gene, which encodes mouse C-type natriuretic peptide (CNP)...
  15. pmc C-type natriuretic peptide stimulates ovarian follicle development
    Yorino Sato
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Mol Endocrinol 26:1158-66. 2012
    C-type natriuretic peptide (CNP) encoded by the NPPC (Natriuretic Peptide Precursor C) gene expressed in ovarian granulosa cells inhibits oocyte maturation by activating the natriuretic peptide receptor (NPR)B (NPRB) in cumulus cells...
  16. doi C-type natriuretic peptide specifically acts on the pylorus and large intestine in mouse gastrointestinal tract
    Chizuru Sogawa
    Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Am J Pathol 182:172-9. 2013
    C-type natriuretic peptide (CNP) exerts its main biological effects by binding to natriuretic peptide receptor B (NPR-B), a membrane-bound guanylyl cyclase receptor that produces cyclic guanosine monophosphate (cGMP)...
  17. pmc Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice
    Nobuko Yamada-Goto
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Diabetes 62:1500-4. 2013
    C-type natriuretic peptide (CNP) and its receptor are abundantly distributed in the brain, especially in the arcuate nucleus (ARC) of the hypothalamus associated with regulating energy homeostasis...
  18. pmc The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel
    Lipin Loo
    Department of Pharmacology, Roy J and Lucile A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 32:11942-55. 2012
    ..NPR-C can be coimmunoprecipitated with Gα(i), and C-type natriuretic peptide (CNP) treatment induced translocation of protein kinase Cε (PKCε) to the plasma membrane of these neurons, which was ..
  19. doi CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles
    Takehito Tsuji
    Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan
    Mol Reprod Dev 79:795-802. 2012
    ..In this study, we examined the expression of Nppc and Npr2, respectively encoding CNP and NPR2, in the ovaries of immature mice...
  20. ncbi C-type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis
    Anita Woods
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Endocrinology 148:5030-41. 2007
    C-type natriuretic peptide (CNP) has recently been identified as a key anabolic regulator of endochondral bone growth, but the cellular and molecular mechanisms involved are incompletely understood...
  21. pmc Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes
    Hanga Agoston
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    BMC Musculoskelet Disord 7:87. 2006
    ..In contrast, recent studies have shown that C-type Natriuretic Peptide (CNP) is an important anabolic regulator of cartilage growth, and loss-of-function mutations in the human CNP receptor ..
  22. ncbi Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth
    Pierre Moffatt
    Shriners Hospital for Children, and Department of Human Genetics, McGill University, Montreal, Quebec H3A 2T5, Canada
    J Biol Chem 282:36454-62. 2007
    ....
  23. pmc Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab -/- mice
    Andrea R Yoder
    Department of Pharmacology, University of Minnesota, Twin Cities, 321 Church St SE, Minneapolis, MN 55455, USA
    Peptides 29:1575-81. 2008
    ..The mutant, called long bone abnormality (lbab), contains a single point mutation that converts an arginine to a glycine in a conserved coding region of the CNP ..
  24. doi C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones
    I Kishimoto
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    J Neuroendocrinol 20:1213-23. 2008
    ..In the present study, we examined the role of C-type natriuretic peptide (CNP), which increases intracellular cGMP upon binding to its receptor, guanylyl cyclase (GC)-B, in the peripheral ..
  25. doi Hypomorphic mutation in mouse Nppc gene causes retarded bone growth due to impaired endochondral ossification
    Takehito Tsuji
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Biochem Biophys Res Commun 376:186-90. 2008
    Long bone abnormality (lbab/lbab) is a spontaneous mutant mouse characterized by dwarfism with shorter long bones...
  26. pmc Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias
    Akihiro Yasoda
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 150:3138-44. 2009
    ..We previously demonstrated that C-type natriuretic peptide (CNP), a member of the natriuretic peptide family, is a potent stimulator of endochondral bone growth...
  27. pmc Regulation of axonal development by natriuretic peptide hormones
    Zhen Zhao
    Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, Neuroscience Graduate Program, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 106:18016-21. 2009
    ..First, the C-type NP (CNP) is expressed in a restricted area of the dorsal spinal cord and provides a cue that is necessary for bifurcation ..
  28. pmc C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons
    Hannes Schmidt
    Department of Developmental Neurobiology, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Proc Natl Acad Sci U S A 106:16847-52. 2009
    ..Here we show that the secreted molecule C-type natriuretic peptide (CNP) induces a cGMP signaling cascade via its receptor particulate guanylyl cyclase Npr2 which is essential for sensory ..
  29. doi Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice
    Takei Kake
    Pharmaceutical Research Department I, Research Division, Chugai Pharmaceutical Company, Shizuoka, Japan
    Am J Physiol Endocrinol Metab 297:E1339-48. 2009
    C-type natriuretic peptide (CNP) plays a critical role in endochondral ossification through guanylyl cyclase-B (GC-B), a natriuretic peptide receptor subtype...
  30. doi C-type natriuretic peptide as a new regulator of food intake and energy expenditure
    Megumi Inuzuka
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 151:3633-42. 2010
    ..we analyzed food intake and energy expenditure of CNP-null mice with chondrocyte-targeted CNP expression (CNP-Tg/Nppc(-/-) mice), in which marked skeletal dysplasia was rescued, to investigate the significance of CNP under minimal ..
  31. doi Circulating C-type natriuretic peptide (CNP) rescues chondrodysplastic CNP knockout mice from their impaired skeletal growth and early death
    Toshihito Fujii
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocrinology 151:4381-8. 2010
    ..mice with an increased circulating CNP under the control of human serum amyloid P component promoter (SAP-Nppc-Tg mice). SAP-Nppc-Tg mice developed prominent overgrowth of bones formed through endochondral ossification...
  32. pmc Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes
    Meijia Zhang
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, People s Republic of China
    Science 330:366-9. 2010
    ..We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC ..
  33. ncbi Identification of a novel osteoblastic gene, inducible by C-type natriuretic peptide, whose transcript might function in mineralization as a noncoding RNA
    A Inoue
    Research Center for Experimental Biology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Calcif Tissue Int 70:111-6. 2002
    We reported previously that C-type natriuretic peptide (CNP) promotes the differentiation and mineralization of osteoblast-like cells...
  34. pmc Expression and differential regulation of natriuretic peptides in mouse macrophages
    A M Vollmar
    Institute of Pharmacology, Toxicology and Pharmacy, University of Munich, Germany
    J Clin Invest 95:2442-50. 1995
    The coexpression of the natriuretic peptides ANP, BNP and CNP as well as their differential regulation in mouse macrophages was demonstrated by quantitative PCR, HPLC analysis, and specific radioimmunoassays...
  35. ncbi Structure, expression, and genomic mapping of the mouse natriuretic peptide type-B gene
    M E Steinhelper
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis
    Circ Res 72:984-92. 1993
    ..This physical linkage between the two natriuretic peptide genes expressed in cardiac tissue may be important for their transcriptional regulation...
  36. pmc Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene
    Y Ogawa
    Department of Medicine, Kyoto University School of Medicine, Japan
    J Clin Invest 93:1911-21. 1994
    ..The present study demonstrates that these mice provide a useful model system with which to assess the roles of BNP in cardiovascular regulation and suggests the potential usefulness of BNP as a long-term therapeutic agent...
  37. ncbi The sites of gene expression of atrial, brain, and C-type natriuretic peptides in mouse fetal development: temporal changes in embryos and placenta
    V A Cameron
    Department of Endocrinology, Christchurch School of Medicine, Christchurch, New Zealand
    Endocrinology 137:817-24. 1996
    Atrial (ANP), brain (BNP), and C-type natriuretic peptide (CNP) belong to a family of hormones important in blood pressure and sodium homeostasis...
  38. ncbi Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)
    Y Ogawa
    Department of Medicine, Kyoto University, Faculty of Medicine, Japan
    Genomics 24:383-7. 1994
    ..chain reaction-analyzed microsatellite length polymorphisms among recombinant inbred strains of mice, the CNP gene (Nppc) was assigned to mouse chromosome 1...
  39. ncbi Isolation, mapping, and regulated expression of the gene encoding mouse C-type natriuretic peptide
    H Huang
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    Am J Physiol 271:H1565-75. 1996
    ..The mouse CNP gene (Nppc) comprised at least two exons and one intron and included several cis-regulatory elements in the 5'-flanking ..
  40. ncbi Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes
    M C Hart
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genomics 39:264-70. 1997
    ..One mouse mutation, de, maps in the vicinity of the alpha 1 gene. No known mouse mutations map to regions near the alpha 2 or alpha 3 genes...
  41. ncbi Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1
    M Heesen
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunogenetics 47:364-70. 1998
    ..Mouse RDC1 is linked to and lies between the genes for the mouse CXC chemokine receptors CXCR2 and CXCR4. The combined data of chromosomal location and sequence similarity suggest that RDC1 is an orphan CXC chemokine receptor...
  42. pmc A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice
    Yan Jiao
    Departments of Orthopaedic Surgery Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    BMC Genet 8:16. 2007
    The long bone abnormality (lbab) mouse is a new autosomal recessive mutant characterized by overall smaller body size with proportionate dwarfing of all organs and shorter long bones...
  43. ncbi The mouse alanine:glyoxylate aminotransferase gene (Agxt1): cloning, expression, and mapping to chromosome 1
    X M Li
    Department of Pediatrics, UCSF School of Medicine, San Francisco, California 94143, USA
    Somat Cell Mol Genet 25:67-77. 1999
    ..At the genomic level, mouse Agxt1 contains 11 exons, spanning 11 Kb, and it maps to the central portion of chromosome 1, a region of known synteny with human distal 2q, where AGXT has been previously mapped (2q36-37)...
  44. ncbi Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor
    Karim Sabrane
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, D 48149 Munster, Germany
    J Biol Chem 278:17963-8. 2003
    ..Increased vasodilating responsiveness to endothelial NO contributes to compensate for the missing vasodilating effect of ANP in SMC GC-A KO mice...
  45. ncbi Regulation of the guanylyl cyclase-B receptor by alternative splicing
    Naohisa Tamura
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 278:48880-9. 2003
    Guanylyl cyclase-B (GC-B) is a single transmembrane receptor that binds C-type natriuretic peptide (CNP)...
  46. ncbi Renal C-type natriuretic peptide and natriuretic peptide receptor B mRNA expression are affected by water deprivation in the Spinifex Hopping mouse
    Rachel A Heimeier
    School of Biological and Chemical Sciences, Deakin University, Geelong, VIC 3217, Australia
    Comp Biochem Physiol A Mol Integr Physiol 136:565-75. 2003
    This study investigated the effect of water deprivation on the expression of C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) mRNA, and the ability of NPR-B to generate cGMP in the Spinifex Hopping mouse, ..
  47. ncbi Embryonic expression and multifunctional actions of the natriuretic peptides and receptors in the developing nervous system
    E Dicicco-Bloom
    Department of Neuroscience and Cell Biology, University of Medicine, Piscataway, NJ 08854, USA
    Dev Biol 271:161-75. 2004
    ..of gene expression for the natriuretic peptides [ANP, brain natriuretic peptide (BNP), type-C natriuretic peptide (CNP)] and their receptors (NPR-A, NPR-B, NPR-C) at several early stages in the embryonic mouse nervous system by in ..
  48. ncbi C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stress
    Barbara Lewko
    Department of Immunopathology, Medical University of Gdansk, Gdansk, Poland
    Kidney Int 66:1001-8. 2004
    ..We investigated whether mechanical stress and high ambient glucose influence cGMP generation in podocytes stimulated with NPs. Additionally, the C-type natriuretic peptide (CNP) system has been characterized in these cells.
  49. ncbi Functional effects of C-type natriuretic peptide and nitric oxide are attenuated in hypertrophic myocytes from pressure-overloaded mouse hearts
    Jun Su
    Heart and Brain Circulation Laboratory, Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    Am J Physiol Heart Circ Physiol 288:H1367-73. 2005
    ..the hypothesis that the negative functional effects caused by nitric oxide (NO) or C-type natriuretic peptide (CNP) through cGMP would be blunted in hypertrophied cardiac myocytes...
  50. ncbi Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci
    F Sugiyama
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 71:70-7. 2001
    ....
  51. ncbi The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone
    C E Seidman
    Science 225:324-6. 1984
    ..Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved...
  52. ncbi Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus
    J J Mullins
    Hypertension 9:518-21. 1987
    ..We have, therefore, begun studying this mutation to determine whether a defect in ANF expression is the underlying cause of the phenotype. Thus far, we have found no major DNA rearrangement close to the Anf gene...
  53. ncbi Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor
    E R Levin
    Department of Medicine, University of California, Irvine 92717
    Am J Physiol 261:R453-7. 1991
    ..The inhibitory effects are not the result of inhibiting the proliferative effects of an endogenous growth factor and are cAMP independent...
  54. ncbi The POU factor Oct-6 and Schwann cell differentiation
    M Jaegle
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 273:507-10. 1996
    ..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally...
  55. ncbi Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes
    N Tamura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    J Mol Cell Cardiol 28:1811-5. 1996
    ..In humans, the BNP gene was located upstream of the ANP gene, approximately 8 kb apart. The present study provides the direct evidence that the ANP and BNP genes are organized in tandem in the mouse and human genomes...
  56. ncbi Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...

Research Grants1

  1. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2002
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..