Nox1

Summary

Gene Symbol: Nox1
Description: NADPH oxidase 1
Alias: GP91-2, MOX1, NOH-1, NOH1, NOX1a, NOX1alpha, Nox-1, NADPH oxidase 1, GP91 phox homolog, NADH/NADPH mitogenic oxidase subunit p65-mox, NADPH oxidase 1 alpha
Species: mouse

Top Publications

  1. ncbi Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
    Botond Banfi
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, Switzerland
    J Biol Chem 278:3510-3. 2003
  2. ncbi Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
    Mieko Nakayama
    Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 332:927-33. 2005
  3. ncbi Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice
    Kuniharu Matsuno
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Circulation 112:2677-85. 2005
  4. ncbi Decreased blood pressure in NOX1-deficient mice
    Gaetan Gavazzi
    Department of Rehabilitation and Geriatrics, Geneva Medical Faculty, 1211 Geneva 4, Switzerland
    FEBS Lett 580:497-504. 2006
  5. pmc The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
    Du Chu Wu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:12132-7. 2006
  6. pmc The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1
    Davide Gianni
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 19:2984-94. 2008
  7. pmc Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy
    Donald J McCrann
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Blood 114:1243-9. 2009
  8. pmc NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice
    Stephanie Carnesecchi
    Department of Pediatrics and Department of Pathology and Immunology, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Am J Respir Crit Care Med 180:972-81. 2009
  9. pmc A differential role for endocytosis in receptor-mediated activation of Nox1
    Francis J Miller
    Department of Medicine, University of Iowa, Iowa City, USA
    Antioxid Redox Signal 12:583-93. 2010
  10. pmc Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition
    KangAe Lee
    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:4097-108. 2012

Research Grants

Scientific Experts

  • Kimiharu Ambe
  • Katrin Schröder
  • Hyehun Choi
  • Norbert Weissmann
  • Li Qian
  • Sha Li
  • Sabrina Bréchard
  • A A Azenabor
  • Stephanie Carnesecchi
  • Silvia S Barbieri
  • Francis Miller
  • S C Frasch
  • Christoph Kleinschnitz
  • Michael Joseph Coffey
  • Timo Kahles
  • Botond Banfi
  • Kuniharu Matsuno
  • Chihiro Yabe-Nishimura
  • Karl Heinz Krause
  • Masato Katsuyama
  • Masakazu Ibi
  • Kazumi Iwata
  • Bojana Stanic
  • J David Lambeth
  • Masayoshi Kato
  • Misaki Matsumoto
  • Christine Deffert
  • Cedric Szyndralewiez
  • Tohru Kamata
  • Melissa J Grimm
  • Bruce A Davidson
  • Jia Zhang
  • Gaetan Gavazzi
  • Dammanahalli K Jagadeesha
  • Rhian M Touyz
  • Aurélia Lelli
  • Patrick Page
  • Suk Hwan Baek
  • Kathy K Griendling
  • Anna E Dikalova
  • Cyril Cheret
  • Olivier Basset
  • Qiang Li
  • Hiroaki Matsubara
  • Eric Ogier-Denis
  • Seo Hyun Choi
  • Louise Tzung Harn Hsieh
  • Ankur Datta
  • Ming Zhan
  • Jennifer L Wilkinson-Berka
  • Jennifer Streeter
  • Mi Wang
  • Robert S Esworthy
  • Hesham M Ismail
  • Zhiping Yang
  • Mark E Cooper
  • Giovanna Leoni
  • Hong Xia Wang
  • Deborah E Citrin
  • Timothy S Blackwell
  • Jie Jiang
  • Rheinallt M Jones
  • Xin Ling Fang
  • Brahm H Segal
  • Stavros Selemidis
  • Ashfaqul Alam
  • Paul R Knight
  • Andrew S Neish
  • Ryo Kodama
  • Wenhao Cui
  • Chao Fan Liang
  • Mona Sedeek
  • Kanako Ikami
  • R Robert Vethanayagam
  • Yugen Zhang
  • Samantha M Yeligar
  • KangAe Lee
  • J Y Youn
  • Ning Li
  • Jessica R Weaver
  • Freddy Heitz
  • Gabor Csanyi
  • Seheli Kajla
  • Hyung Kyoung Lee
  • Maysam Takapoo
  • Ramesh C Bhalla
  • Monisha Dhiman
  • Junling Yang
  • Dai Shiba
  • Natalia A Kaniuk

Detail Information

Publications111 found, 100 shown here

  1. ncbi Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
    Botond Banfi
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, Switzerland
    J Biol Chem 278:3510-3. 2003
    b>NOX1, an NADPH oxidase expressed predominantly in colon epithelium, shows a high degree of similarity to the phagocyte NADPH oxidase. However, superoxide generation by NOX1 has been difficult to demonstrate...
  2. ncbi Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
    Mieko Nakayama
    Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 332:927-33. 2005
    ..Angiotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes. This mechanism may be a novel therapeutic target for preventing beta-cell damage...
  3. ncbi Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice
    Kuniharu Matsuno
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Circulation 112:2677-85. 2005
    ..NADPH oxidase is a major source of superoxide generated in vascular tissues. Although Nox1 has been identified in vascular smooth muscle cells as a new homolog of gp91phox (Nox2), a catalytic subunit of ..
  4. ncbi Decreased blood pressure in NOX1-deficient mice
    Gaetan Gavazzi
    Department of Rehabilitation and Geriatrics, Geneva Medical Faculty, 1211 Geneva 4, Switzerland
    FEBS Lett 580:497-504. 2006
    To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure...
  5. pmc The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
    Du Chu Wu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:12132-7. 2006
    ..These findings suggest a non-cell-autonomous mechanism through which inflammation could hasten motor neuron death and contribute to the selective motor neuronal degeneration in ALS...
  6. pmc The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1
    Davide Gianni
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 19:2984-94. 2008
    ..To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood...
  7. pmc Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy
    Donald J McCrann
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Blood 114:1243-9. 2009
    ..mouse MKs isolated from thrombopoietin (TPO)-treated bone marrow (BM) cultures indicated high expression of Nox1, a weak expression of Nox4, and no significant expression of Nox2...
  8. pmc NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice
    Stephanie Carnesecchi
    Department of Pediatrics and Department of Pathology and Immunology, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Am J Respir Crit Care Med 180:972-81. 2009
    ..ROS are produced by mitochondrial chain transport, but also by NADPH oxidase (NOX) family members. Although NOX1 and NOX2 are expressed in the lungs, their precise function has not been determined until now.
  9. pmc A differential role for endocytosis in receptor-mediated activation of Nox1
    Francis J Miller
    Department of Medicine, University of Iowa, Iowa City, USA
    Antioxid Redox Signal 12:583-93. 2010
    ..study was to test the hypothesis that endocytosis is necessary for generation of reactive oxygen species (ROS) by Nox1 and for redox-dependent signaling in smooth muscle cells (SMCs)...
  10. pmc Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition
    KangAe Lee
    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:4097-108. 2012
    ..In contrast, soft microenvironments inhibit the membrane localization of Rac1b and subsequent redox changes. These results reveal a novel mechanotransduction pathway in the regulation of epithelial plasticity via EMT...
  11. pmc A model of interaction between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and apocynin analogues by docking method
    Jie Jiang
    College of Pharmacy, Jinan University, Guangzhou 510632, China
    Int J Mol Sci 14:807-17. 2013
    ..The key interactions might be valuable to discover and screen apocynin analogues as potent inhibitors of NADPH oxidase...
  12. pmc NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of acute respiratory distress syndrome
    Stephanie Carnesecchi
    Department of Pediatrics Geneva, Switzerland Department of Pathology and Immunology, Medical School, University of Geneva Switzerland
    Int J Clin Exp Pathol 7:537-51. 2014
    ..contribute to alveolar cell death in acute respiratory distress syndrome (ARDS) and we previously demonstrated that NOX1-derived ROS contributed to hyperoxia-induced alveolar cell death in mice...
  13. ncbi Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 27:1736-43. 2007
    ..Basic fibroblast growth factor (bFGF) stimulates vascular smooth muscle cell (SMC) migration. We determined whether bFGF increases SMC reactive oxygen-species (ROS) and studied the role of ROS for SMC migration...
  14. ncbi H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1
    Young Mi Go
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5837-45. 2004
    The gp91phox homologue Nox1 produces H2O2, which induces cell growth, transformation, and tumorigenicity...
  15. ncbi Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability
    Camille Taillé
    INSERM, Unité 408, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Biol Chem 279:28681-8. 2004
    ..This study provides a new mechanism to explain HO-1 anti-oxidant properties...
  16. pmc Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation
    Moo Yeol Lee
    Emory University, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 29:480-7. 2009
    ..Here, the role of the vascular smooth muscle cell (VSMC) Nox1 in neointima formation was studied using genetically modified animal models.
  17. doi Glycogen synthase kinase 3beta and beta-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages
    Jin Sik Kim
    Department of Biochemistry and Molecular Biology, Yeungnam University, Daegu, Korea
    FEBS J 277:2830-7. 2010
    ..In the vascular system, the major source of reactive oxygen species is the NADPH oxidase (Nox) family. Nox1 is induced by lipopolysaccharide (LPS) in macrophages, but the expression mechanism is not fully understood...
  18. doi Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
    Mona Sedeek
    Kidney Research Center, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Clin Sci (Lond) 124:191-202. 2013
    ..In the present study, we tested the hypothesis that GKT136901, a Nox1/4 inhibitor, prevents the development of nephropathy in db/db (diabetic) mice...
  19. pmc NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion
    Ning Li
    Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland
    Diabetes 61:2842-50. 2012
    ..Results also show reciprocal inhibition between the cAMP/PKA pathway and ROS...
  20. doi Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4
    Chao Fan Liang
    Department of Pharmacology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Arterioscler Thromb Vasc Biol 33:777-84. 2013
    ..To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function...
  21. pmc NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy
    Jennifer L Wilkinson-Berka
    1 Department of Immunology, Monash University, Melbourne, Australia
    Antioxid Redox Signal 20:2726-40. 2014
    ..Our major aim was to determine the contribution of NOX isoforms (1, 2, and 4) to a rodent model of retinopathy of prematurity...
  22. pmc Urotensin II inhibits skeletal muscle glucose transport signaling pathways via the NADPH oxidase pathway
    Hong Xia Wang
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
    PLoS ONE 8:e76796. 2013
    ..Our data imply a role for UII at the molecular level in glucose homeostasis, and possibly in skeletal muscle insulin resistance in T2DM. ..
  23. pmc Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species
    Rheinallt M Jones
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    EMBO J 32:3017-28. 2013
    ..Here, we report that commensal bacteria, particularly members of the genus Lactobacillus, can stimulate NADPH oxidase 1 (Nox1)-dependent ROS generation and consequent cellular proliferation in intestinal stem cells upon initial ..
  24. doi Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling
    Kazumi Iwata
    From the Departments of Pharmacology K Iwata, K Ikami, K M, M I, M M, W C, J Z, K Z, C Y N, Anatomy and Developmental Biology D S, T Yokoyama, and Radioisotope Center M K, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Regenerative Medicine and Stem Cell Biology, University of Tsukuba, Tsukuba, Japan T Yamashita, O O Department of Biomedical Engineering, Sapporo Medical University School of Medicine, Sapporo, Japan N T, Y K
    Arterioscler Thromb Vasc Biol 34:110-9. 2014
    ..Because the PAH-like phenotype was demonstrated in mice deficient in Nox1 gene (Nox1(-/Y)) raised under normoxia, the aim of this study was to clarify how the lack of NOX1/NADPH oxidase ..
  25. pmc Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2
    Robert S Esworthy
    Department of Radiation Biology and Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 68:315-25. 2014
    ..To test whether NADPH oxidase 1 (Nox1) contributes to colitis, we generated B6 triple-KO (TKO) mice to study their phenotype...
  26. doi Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: role of NADPH oxidase
    Mi Wang
    Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan 430030, China
    Free Radic Biol Med 71:109-20. 2014
    ..Both Nox4 and Nox1 siRNA prevented SEA-induced upregulation of CB1, α-SMA, collagen I, and TIMP-1 by inhibition of O2(-) production, ..
  27. pmc Phosphorylation of Nox1 regulates association with NoxA1 activation domain
    Jennifer Streeter
    From the Departments of Internal Medicine B M S, S J, B S, W H T, F J M, Microbiology J C D H, Anatomy and Cell Biology J S, Biochemistry L G, and Protein Crystallography Facility L G, University of Iowa, Iowa City and Veterans Affair Medical Center, Iowa City, IA F J M
    Circ Res 115:911-8. 2014
    Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease...
  28. pmc Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target
    Zhiping Yang
    Department of Environmental Health, Harvard School of Public Health, Boston, United States
    elife 3:. 2014
    ..The data identify a novel mechanism for host defense via NOS3 and suggest a potential therapeutic strategy to reduce secondary bacterial pneumonia after influenza. ..
  29. pmc Diapocynin, a dimer of the NADPH oxidase inhibitor apocynin, reduces ROS production and prevents force loss in eccentrically contracting dystrophic muscle
    Hesham M Ismail
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland
    PLoS ONE 9:e110708. 2014
    ..These findings support the central role played by NOX-ROS in the pathogenic cascade leading to muscular dystrophy and suggest diapocynin as an effective NOX inhibitor that might be helpful for future therapeutic approaches. ..
  30. pmc Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent
    Ankur Datta
    Department of Pediatrics, Northwestern University, Chicago, Illinois
    Am J Physiol Lung Cell Mol Physiol 309:L369-77. 2015
    ..In addition, early, but not late, postnatal hyperoxia resulted in induction of NOX1 expression that was mitochondrial ROS dependent...
  31. doi NOX1 mediates chemoresistance via HIF1α/MDR1 pathway in gallbladder cancer
    Ming Zhan
    Department of Biliary Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Biochem Biophys Res Commun 468:79-85. 2015
    b>NADPH oxidase 1 (NOX1) plays a key role in tumorigenesis and metastasis through generating reactive oxygen species (ROS), an important intracellular signaling molecule...
  32. doi Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis
    Louise Tzung Harn Hsieh
    Pharmazentrum Frankfurt, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    Matrix Biol 49:61-81. 2016
    ..In primary murine macrophages, biglycan triggered NOX1/4-mediated ROS generation, thereby enhancing IL-1β expression...
  33. pmc The ROS-generating oxidase Nox1 is required for epithelial restitution following colitis
    Masayoshi Kato
    Department of Molecular Biology and Biochemistry, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Exp Anim 65:197-205. 2016
    ..Our study using experimental colitis in mice showed that repair of the mucosal layer did not occur in Nox1-deficient mice following dextran sulfate sodium-induced colitis...
  34. pmc Effects of NOX1 on fibroblastic changes of endothelial cells in radiation‑induced pulmonary fibrosis
    Seo Hyun Choi
    Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul 139 706, Republic of Korea
    Mol Med Rep 13:4135-42. 2016
    ..or without pre‑treatment with VAS2870, a novel NADPH oxidase (NOX) inhibitor, or small hairpin (sh)RNA against NOX1, ‑2 or ‑4...
  35. pmc Role of type II pneumocyte senescence in radiation-induced lung fibrosis
    Deborah E Citrin
    Affiliations of authors Radiation Oncology Branch DEC, US, JAH, WS, SZ, HA, Ay, EJC and Radiation Biology Branch AS, AT, Center for Cancer Research, National Institutes of Health, Bethesda, MD
    J Natl Cancer Inst 105:1474-84. 2013
    ..Radiation is a commonly delivered therapeutic modality for cancer. The causes underlying the chronic, progressive nature of radiation injury in the lung are poorly understood...
  36. ncbi NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes
    Miklos Geiszt
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:299-306. 2003
    ..We studied the expression and function of a recently described source of ROS, NAD(P)H oxidase 1 or Nox1, which has been associated with cell proliferation...
  37. pmc NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells
    Benoit Schneider
    Différenciation cellulaire et Prions, Centre National de la Recherche Scientifique Unité Propre de Recherche 1983, Institut Andre Lwoff, 7 rue Guy Moquet, BP8, 94 801 Villejuif Cedex, France
    Proc Natl Acad Sci U S A 100:13326-31. 2003
    ..These data argue for an ubiquitous function of PrPC in cell-redox homeostasis through ROS production...
  38. pmc IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes
    Urmila Maitra
    Departments of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Biol Chem 284:35403-11. 2009
    ..Taken together, our study reveals IRAK-1 as a novel component involved in the generation of ROS induced by LPS...
  39. doi Calcium-independent phospholipase A2beta-Akt signaling is involved in lipopolysaccharide-induced NADPH oxidase 1 expression and foam cell formation
    Sun Hye Lee
    Aging Associated Vascular Disease Research Center, Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, South Korea
    J Immunol 183:7497-504. 2009
    ..This study reveals the control mechanism of the gene for NADPH oxidase 1 (Nox1), which produces ROS in the formation of foam cells by stimulating TLR4...
  40. doi Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
    S Ben Mkaddem
    INSERM, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris, France
    Cell Death Differ 17:1474-85. 2010
    ....
  41. pmc NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon
    Nicolas Coant
    INSERM, U773, Centre de Recherche Bichat Beaujon, CRB3, BP 416, 16 rue Henri Huchard, Paris 75018, France
    Mol Cell Biol 30:2636-50. 2010
    ..Here we show that NADPH oxidase 1 (NOX1), a reactive oxygen species (ROS)-producing oxidase that is highly expressed in colonic epithelial ..
  42. pmc Genetic interleukin-10 deficiency causes vascular remodeling via the upregulation of Nox1
    Jagadeesha K Dammanahalli
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Hypertens 29:2116-25. 2011
    Interleukin (IL)-10 is an anti-inflammatory cytokine. Nox1 is a mitogenic oxidase (p65-mox). The objective of this study was to test a hypothesis that IL-10 deficiency would cause vascular remodeling via the upregulation of Nox1.
  43. pmc NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease
    Monisha Dhiman
    Department of Microbiology and Immunology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Pathol 225:583-96. 2011
    ..cruzi infection, and bystander effects of heart-infiltrating phagocytes and CD8(+) T cells resulting in cardiac remodelling in chagasic mice...
  44. pmc Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration
    Dammanahalli K Jagadeesha
    Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242, USA
    Cardiovasc Res 93:406-13. 2012
    ..The goal of this study was to define the signalling pathway by which Nox1 NAPDH oxidase mediates SMC migration.
  45. doi RGS2 is a negative regulator of STAT3-mediated Nox1 expression
    Hyung Kyoung Lee
    Department of Biochemistry and Molecular Biology, Aging Associated Vascular Disease Research Center, College of Medicine, Yeungnam University, Nam Gu, Daegu, South Korea
    Cell Signal 24:803-9. 2012
    b>NADPH oxidase 1 (Nox1) is essential for reactive oxygen species production in the innate immune responses mediated by toll-like receptor (TLR), but the mechanism regulating its expression remains uncertain...
  46. doi Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance
    Masakazu Ibi
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Neurosci 31:18094-103. 2011
    ..Here, we report a novel role for the superoxide-generating enzyme NOX1/NADPH oxidase in the regulation of analgesia and acute analgesic tolerance...
  47. doi A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling
    Seheli Kajla
    Department of Molecular Biology and Biochemistry, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    FASEB J 26:2049-59. 2012
    ..Our principal aim in this study was to investigate whether superoxide-generating NADPH oxidase1 (Nox1) is involved in NRX-regulated Wnt signaling in intestinal and colon epithelial cells...
  48. pmc Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases
    Samantha M Yeligar
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University, Atlanta, GA 30322, USA
    J Immunol 188:3648-57. 2012
    ..Therefore, we hypothesized that chronic alcohol consumption increases AM oxidant stress through modulation of Nox1, Nox2, and Nox4 expression...
  49. doi Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction
    Jessica R Weaver
    Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23501, United States
    Mol Cell Endocrinol 358:88-95. 2012
    ..Inhibitors of NADPH oxidase, apocynin and diphenyleneiodonium, and a dual selective NOX1/4 inhibitor, blocked ROS generation (p<0.01) and induction of MCP-1 (p<0...
  50. pmc The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes
    J Y Youn
    Division of Molecular Medicine, Cardiovascular Research Laboratories, Departments of Anesthesiology and Medicine, David Geffen School of Medicine, University of California Los Angeles, 650 Charles E Young Drive, Los Angeles, CA 90095, USA
    Diabetologia 55:2069-79. 2012
    ..The aim of the present study was to test the hypothesis that one or more NOX isoform(s) mediate(s) diabetic uncoupling of eNOS, which has been shown to occur in patients with diabetes to contribute to endothelial dysfunction...
  51. doi NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis
    Kuniharu Matsuno
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Free Radic Biol Med 53:1718-28. 2012
    The functional significance of NOX1/NADPH oxidase in the heart has not been explored due to its low expression relative to other NOX homologs identified so far...
  52. pmc Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1
    Gabor Csanyi
    Vascular Medicine Institute, Department of Pharmacology and Chemical Biology, University of Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 32:2966-73. 2012
    ..This study was designed to test the hypothesis that TSP1 stimulates reactive oxygen species production in vascular smooth muscle cells and induces vascular dysfunction by promoting oxidative stress...
  53. doi ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence
    Ryo Kodama
    Department of Molecular Biology and Biochemistry, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, 390 8621, Japan
    Genes Cells 18:32-41. 2013
    ..show that through the Ras/MEK pathway, Ras oncogene up-regulated the expression of superoxide-generating oxidases, Nox1 in rat REF52 cells and Nox4 in primary human lung TIG-3 cells, leading to an increase in intracellular level of ROS...
  54. pmc Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
    Giovanna Leoni
    Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Invest 123:443-54. 2013
    ..A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1. We show that epithelial cell migration was regulated by this signaling cascade through oxidative inactivation of ..
  55. pmc NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury
    Bruce A Davidson
    Department of Anesthesiology, University at Buffalo School of Medicine, Buffalo, NY 14214, USA
    J Immunol 190:1714-24. 2013
    ..These results also point to Nrf2 as a therapeutic target to limit ALI by attenuating neutrophil-induced cellular injury...
  56. pmc The anorexigenic effect of serotonin is mediated by the generation of NADPH oxidase-dependent ROS
    Xin Ling Fang
    College of Animal Science, South China Agricultural University, Guangzhou 510642, China
    PLoS ONE 8:e53142. 2013
    ..Our study demonstrates for the first time that the anorexigenic effect of 5-HT is mediated by the generation of ROS in the hypothalamus through an NADPH oxidase-dependent pathway...
  57. pmc Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice
    Melissa J Grimm
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 190:4175-84. 2013
    ..Taken together, our studies identify a central role for monocyte/macrophage NADPH oxidase in controlling fungal infection and in limiting acute lung inflammation...
  58. pmc Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress
    Stavros Selemidis
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 8:e60792. 2013
    ..In addition, lung epithelial and endothelial cells express the Nox1 isoform of NADPH oxidase, placing this enzyme at key sites to regulate influenza A virus-induced lung inflammation...
  59. doi The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex
    Aurélia Lelli
    University Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, Paris, 75651, France
    Glia 61:1542-55. 2013
    ..Nox2 therefore modulates the migration of microglia and their development. ..
  60. ncbi Elicitation of reactive oxygen species in Chlamydia pneumoniae-stimulated macrophages: a Ca2+-dependent process involving simultaneous activation of NADPH oxidase and cytochrome oxidase genes
    Anthony A Azenabor
    Department of Health Sciences, Enderis Hall, University of Wisconsin, Milwaukee, WI 53211, USA
    Med Microbiol Immunol 194:91-103. 2005
    ..The data reported here imply that macrophages infected with C. pneumoniae produce ROS through membrane-associated NADPH oxidase with oxidative phosphorylation levels depending on Ca2+ influx signals...
  61. pmc Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections
    Robert E Brennan
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    Infect Immun 72:6666-75. 2004
    ..burnetii infection compared to wild-type mice. Together, these results strongly support a role for both RNI and ROI in the host control of C. burnetii infection...
  62. ncbi NADPH oxidase restrains the matrix metalloproteinase activity of macrophages
    Sean Y Kassim
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:30201-5. 2005
    ..These findings indicate that reactive intermediates provide a physiological mechanism to protect tissues from excessive macrophage-mediated damage during inflammation...
  63. ncbi Expression and modulation of an NADPH oxidase in mammalian astrocytes
    Andrey Y Abramov
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:9176-84. 2005
    ..The astrocytic NADPH oxidase is likely to play important roles in CNS physiology and pathology...
  64. ncbi NAD(P)H oxidase contributes to the progression of remote hepatic parenchymal injury and endothelial dysfunction, but not microvascular perfusion deficits
    Robert B Dorman
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W Markham Street 638, Little Rock, AR 72205 7199, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1025-32. 2006
    ..The data also suggest that Nox enzymes, not XO, are involved in the progression of compromised hepatic parenchymal and endothelial integrity during a systemic inflammatory response...
  65. pmc Novel transcripts of Nox1 are regulated by alternative promoters and expressed under phenotypic modulation of vascular smooth muscle cells
    Noriaki Arakawa
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem J 398:303-10. 2006
    ..In vascular smooth muscle cells (VSMC), expression of NOX1 (NADPH oxidase 1), a catalytic subunit of NADPH oxidase, is low and is induced upon stimulation by vasoactive factors, while ..
  66. pmc Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
    Chris D Ellson
    Inositide Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    J Exp Med 203:1927-37. 2006
    ..aureus translated into a severe, CGD-like defect in the killing of this organism both in vitro and in vivo, defining p40(phox) as an essential component in bacterial killing...
  67. ncbi Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells
    Priya Ranjan
    Department of Pathology and Vermont Cancer Center, University of Vermont College of Medicine, Burlington, 05405, USA
    Antioxid Redox Signal 8:1447-59. 2006
    ..In mouse lung epithelial cells that express Nox1, Nox2, Nox4, p22(phox), p47(phox), p67(phox), and Noxo1, overexpression of Nox1 delayed cell cycle withdrawal by ..
  68. ncbi In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection
    Robert J Snelgrove
    Kennedy Institute of Rheumatology, Imperial College London, Hammersmith, London, United Kingdom
    J Immunol 177:5509-16. 2006
    ..These findings are in sharp contrast to the protective potential of ROS against other fungal pathogens, and highlight the pivotal role that ROS can fulfill in shaping the profile of the host's immune response...
  69. pmc Expression of Nox1 in 3T3 cells increases cellular acid production but not proton conductance
    Vincent Gaggioli
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Arch Biochem Biophys 459:189-96. 2007
    The role of the NADPH oxidase homolog 1 (Nox1) in plasma membrane H(+) conductance and cellular H(+) production was investigated in 3T3 cells stably expressing Nox1 (Nox1 3T3) compared to vector-expressing control cells (mock 3T3)...
  70. ncbi Stimulation of ES-cell-derived cardiomyogenesis and neonatal cardiac cell proliferation by reactive oxygen species and NADPH oxidase
    Martina Buggisch
    Department of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany
    J Cell Sci 120:885-94. 2007
    ..Our data suggest that proliferation of neonatal and ES-cell-derived cardiac cells involves ROS-mediated signalling cascades and point towards an involvement of NADPH oxidase in cardiovascular differentiation of ES cells...
  71. ncbi Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Glia 55:758-71. 2007
    ..Cultured rat astrocytes express mRNAs encoding for the regulatory subunit p47(phox), NOX1, 2, and 4, and the dual oxidases (DUOX)1 and 2, but not NOX3...
  72. ncbi NOX1 deficiency protects from aortic dissection in response to angiotensin II
    Gaetan Gavazzi
    Department of Geriatrics, University Hospital of Grenoble, Grenoble, France
    Hypertension 50:189-96. 2007
    ..in mice deficient in the superoxide-generating reduced nicotinamide-adenine dinucleotide phosphate oxidase NOX1. Seven days of treatment with the hypertensive agent angiotensin II (3 mg/kg per day) led to aortic dissection in ..
  73. ncbi Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal
    Cleber E Teixeira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Sao Paulo, Brazil
    J Pharmacol Exp Ther 322:1093-102. 2007
    ....
  74. ncbi Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
    Srinivasa R Datla
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Victoria, Australia
    Hypertension 50:636-42. 2007
    ..Thus, systemic expression of HO-1 suppresses NADPH oxidase activity by mechanisms at least partly mediated by the bile pigment bilirubin, thereby reducing oxidative stress...
  75. ncbi NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis
    Michael J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    J Leukoc Biol 82:1585-91. 2007
    ..In view of the antimicrobial actions of LT, a reduction in LT synthetic capacity by AM from NADPH oxidase KO mice may contribute to the susceptibility of these animals to infection...
  76. ncbi NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J W Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Stroke 38:3000-6. 2007
    ..We hypothesized that NADPH oxidases mediate blood-brain barrier (BBB) disruption and contribute to tissue damage in ischemia/reperfusion...
  77. doi Regulation of TGFbeta1-mediated collagen formation by LOX-1: studies based on forced overexpression of TGFbeta1 in wild-type and lox-1 knock-out mouse cardiac fibroblasts
    Changping Hu
    Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    J Biol Chem 283:10226-31. 2008
    ..Further, the activation of MAPK pathway appears to be downstream of TGFbeta(1)-reactive oxygen species-LOX-1 cascade...
  78. doi Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension
    Alvaro Yogi
    Kidney Research Centre, Ontario Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Hypertension 51:500-6. 2008
    ..Here we sought to determine whether a gp91phox homologue, Nox1, may be important in blood pressure elevation and activation of redox-sensitive pathways in a model in which the ..
  79. doi Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain
    Masakazu Ibi
    Department of Pharmacology and Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Neurosci 28:9486-94. 2008
    ..In mice lacking Nox1 (Nox1(-/Y)), a catalytic subunit of NADPH oxidase, thermal and mechanical hyperalgesia was significantly attenuated,..
  80. doi Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase
    Cyril Cheret
    INSERM, Unité Mixte de Recherche UMR 711, Institut Fédératif de Recherche 70, 75013 Paris, France
    J Neurosci 28:12039-51. 2008
    ..Here we show that microglia also express Nox1 and other components of nonphagocyte NADPH oxidases, including p22(phox), NOXO1, NOXA1, and Rac1/2...
  81. ncbi Alveolar macrophages from septic mice promote polymorphonuclear leukocyte transendothelial migration via an endothelial cell Src kinase/NADPH oxidase pathway
    Zhanfei Wang
    Critical Illness Research, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    J Immunol 181:8735-44. 2008
    ..Collectively, our findings indicate that the PMN transendothelial migration induced by septic AMphi is dependent on the generation of superoxide in endothelial cells via the Src kinase/NADPH oxidase signaling pathway...
  82. doi NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle
    Olivier Basset
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    Antioxid Redox Signal 11:2371-84. 2009
    The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood...
  83. doi Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues
    Hideyuki Sasaki
    Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Free Radic Biol Med 47:189-99. 2009
    ..RANKL reciprocally increased Nox1 mRNA levels and newly induced Nox4 transcript expression...
  84. doi Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemia
    Huaqing Zhu
    Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada
    J Mol Cell Cardiol 47:264-74. 2009
    ..The sex difference in TNF-alpha expression is estrogen-dependent and mediated via Rac1 dependent NADPH oxidase/ERK1/2 and p38 MAPK pathway in LPS-stimulated hearts...
  85. doi Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke
    Katherine A Jackman
    Department of Pharmacology, Monash University, Clayton, Melbourne, Victoria 3800, Australia
    Brain Res 1286:215-20. 2009
    ..Mice genetically targeted for the superoxide-forming vascular NADPH oxidase subunit, NOX1, have a blunted hypertensive response to Ang II...
  86. doi NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Circ Res 105:537-44. 2009
    ..The role of hypoxia and reactive oxygen species (ROS) in mobilization and function of these cells is incompletely understood...
  87. doi Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: studies in PON2-deficient mice
    Edna Meilin
    The Lipid Research Laboratory, Technion, The Rappaport Family Institute for Research in the Medical Science, Rambam Medical Center, Haifa, Israel
    Atherosclerosis 208:390-5. 2010
    ..The present study investigates the role of paraoxonase 2 (PON2) in the attenuation of macrophage triglycerides (TG) biosynthesis, and oxidative stress, under diabetic conditions...
  88. pmc Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase
    Meng Xiang
    Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 44:333-40. 2011
    ..Oxidant signaling by neutrophil NADPH oxidase is an important determinant of activation of endothelial NADPH oxidase after HS...
  89. pmc NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis
    Aleksandr E Vendrov
    Department of Medicine, McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Biol Chem 285:26545-57. 2010
    ..GKT136901, a specific inhibitor of Nox1- and Nox4-containing NADPH oxidase activity, attenuated ROS generation and atherosclerosis and decreased CD44 and ..
  90. doi NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice
    Timo Kahles
    Department ofNeurology, University Hospital, Goethe University Frankfurt, Frankfurt Main, Germany
    Neurobiol Dis 40:185-92. 2010
    ..In contrast, only little is known about the contribution of the Nox1 homologue in this context...
  91. pmc Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance
    Tim Doyle
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Neurosci Lett 483:85-9. 2010
    ..These results continue to support the critical role of these reactive oxygen and nitrogen species in pain while advancing our knowledge of their biomolecular sources...
  92. pmc Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling
    Anna E Dikalova
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 299:H673-9. 2010
    ..oxidase (Nox) 1 upregulation in vascular smooth muscle and endothelial function, transgenic mice overexpressing Nox1 in smooth muscle cells (Tg(SMCnox1)) were subjected to angiotensin II (ANG II)-induced hypertension...
  93. ncbi Quantification of transforming growth factor beta 1 levels in metastatic axillary lymph node tissue extracts from breast cancer patients: a new specimen source
    Vesna Ivanović
    Laboratory for Radiobiology and Molecular Genetics, Institute of Nuclear Sciences Vinia, Serbia
    Anal Quant Cytol Histol 31:288-95. 2009
    ....
  94. pmc An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation
    Bojana Stanic
    Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Arterioscler Thromb Vasc Biol 30:2234-41. 2010
    ..To examine the effect of an oxidized extracellular oxidation-reduction (redox) state (E(h)) on the expression of NADPH oxidases in vascular cells...
  95. pmc Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
    Christoph Kleinschnitz
    Neurologische Klinik und Poliklinik, Universitat Wurzburg, Wurzburg, Germany
    PLoS Biol 8:. 2010
    ..Mice deficient in NOX4 (Nox4(-/-)) of either sex, but not those deficient for NOX1 or NOX2, were largely protected from oxidative stress, blood-brain-barrier leakage, and neuronal apoptosis, after ..
  96. doi Citrobacter rodentium infection induces MyD88-dependent formation of ubiquitinated protein aggregates in the intestinal epithelium
    Natalia A Kaniuk
    Cell Biology Program, Hospital for Sick Children, Toronto, Ont, Canada
    J Innate Immun 3:83-98. 2011
    ..Aggregate formation correlated with MyD88-dependent induction of NADPH oxidase 1, implicating reactive oxygen species in their formation...
  97. doi Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species
    Noriaki Kamio
    Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    Free Radic Res 45:336-41. 2011
    ..Interestingly, transfection with the DGKα-specific small interfering RNA attenuated the expression level of Nox1 mRNA in gAd-treated RAW 264 cells. In addition, the DGKα knockdown with siRNA suppressed gAd-induced NO release.
  98. pmc Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4
    Netanya Y Spencer
    Department of Anatomy and Cell Biology, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:8977-87. 2011
    ..Using electron paramagnetic resonance, we investigated whether several NADPH oxidases (NOX1, 2, and 4) and known activators of NOX (Rac1, Rac2, p22(phox), and p47(phox)) contribute to nuclear O(2)(·-) ..
  99. pmc Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
    Sarah Garrido-Urbani
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e14665. 2011
    ..We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired angiogenesis...
  100. pmc Role for Nox1 NADPH oxidase in atherosclerosis
    Andrea L Sheehan
    Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, United States
    Atherosclerosis 216:321-6. 2011
    Examine the contribution of Nox1 NADPH oxidase to atherogenesis.
  101. doi Angiotensin II plays a critical role in diabetic pulmonary fibrosis most likely via activation of NADPH oxidase-mediated nitrosative damage
    Junling Yang
    Department of Pulmonary Medicine, Second Hospital of Jilin University, Changchun, China
    Am J Physiol Endocrinol Metab 301:E132-44. 2011
    ..These results suggest that Ang II plays a critical role in diabetic lung fibrosis, which is most likely caused by NOX activation-mediated nitrosative damage...

Research Grants2

  1. CYTOKINE DYSFUNCTION AND LUNG 5LO METABOLISM IN AIDS
    Michael Coffey; Fiscal Year: 2002
    ..This proposal will further enhance our ability to correct this defect and help boost AM, PBM, and PMN defenses against opportunistic infections in the lung in HIV disease. ..
  2. Glutathione Peroxidase & Redox State in Atherosclerosis
    Francis Miller; Fiscal Year: 2009
    ..of reduction in GPx-1 activity on smooth muscle cells are mediated by expression of the NADPH oxidase subunits Nox1 and Nox4...