Notch4

Summary

Gene Symbol: Notch4
Description: notch 4
Alias: Int-3, Int3, Notch gene homolog 4, neurogenic locus notch homolog protein 4
Species: mouse

Top Publications

  1. ncbi Notch signaling in the mammalian central nervous system: insights from mouse mutants
    Keejung Yoon
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:709-15. 2005
  2. pmc Notch signaling controls liver development by regulating biliary differentiation
    Yiwei Zong
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 136:1727-39. 2009
  3. pmc Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages
    HASINA HAMILTON OUTTZ
    Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    J Immunol 185:4363-73. 2010
  4. ncbi Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation
    Marina A Vorontchikhina
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA
    Gene Expr Patterns 5:701-9. 2005
  5. ncbi Coexpression of Cux-1 and Notch signaling pathway components during kidney development
    Madhulika Sharma
    Department of Anatomy and Cell Biology, and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Dev Dyn 231:828-38. 2004
  6. ncbi Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
    N Villa
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095 1737, USA
    Mech Dev 108:161-4. 2001
  7. ncbi Characterization of Notch receptor expression in the developing mammalian heart and liver
    Kathleen M Loomes
    Division of Gastroenterology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med Genet 112:181-9. 2002
  8. pmc Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease
    Patrick A Murphy
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, University of California, San Francisco, CA, USA
    Lab Invest 89:971-82. 2009
  9. ncbi Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion
    H Uyttendaele
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Biol 196:204-17. 1998
  10. pmc Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    Xiaofeng Zheng
    Departments of Cell and Molecular Biology and Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3368-73. 2008

Scientific Experts

  • Vuk P Jovanovic
  • Madhulika Sharma
  • Jay L Vivian
  • Nurul H Sarkar
  • Doug Miniati
  • Yi Zhang
  • Norio Yamamoto
  • M Kasahara
  • C K Haston
  • K Kusumi
  • Darren B Taichman
  • Lizi Wu
  • Catarina Catela
  • Y Shirayoshi
  • L A Milner
  • Suk Keun Lee
  • T Ito
  • Vincent E Sollars
  • Thomas Gridley
  • Jan Kitajewski
  • Youping Sun
  • R Callahan
  • H Uyttendaele
  • Carrie J Shawber
  • Christina Helbig
  • Preethi Vijayaraj
  • Ryan Humphreys
  • D Gallahan
  • Diana C Chong
  • Matthew R Mysliwiec
  • Brigitte Laforest
  • Yiwei Tony Zhu
  • HASINA HAMILTON OUTTZ
  • Donna Nichol
  • Kristy Red-Horse
  • Monica Corada
  • A Raafat
  • Patrick A Murphy
  • Yiwei Zong
  • Emery H Bresnick
  • David Salomon
  • Yoshiaki Okamura
  • Xiaofeng Zheng
  • Robert Callahan
  • Alex Robert-Moreno
  • J Kitajewski
  • H Scott Baldwin
  • Jing Wu
  • Kyosuke Takeshita
  • John S Lee
  • Freddy Radtke
  • Seungwoon Seo
  • Patricia Hainaud
  • Liam M Casey
  • Christine Carson
  • G H Smith
  • Takeo Kitamoto
  • Timothy R Carlson
  • Marina A Vorontchikhina
  • Srividya Subramanian
  • Jeffrey C Francis
  • Keejung Yoon
  • Linghong Chen
  • Sarah Cormier
  • Michael T Tetzlaff
  • Ryo Sumazaki
  • Roi Gazit
  • Cornelia Leimeister
  • Takamune Takahashi
  • Yuji Seta
  • A J Hayes
  • Kathleen M Loomes
  • Jennifer Brennan
  • Natalia Schröder
  • Steven Goudy
  • Peter Oettgen
  • Koen Wagner
  • Rebecca Gentek
  • Lawrence S Prince
  • Eric Eldering
  • William C Aird
  • Derk Amsen
  • Scott Baldwin
  • Xianghu Qu
  • Kathleen Loomes
  • Meredith Wasserman
  • T Mizutani
  • Katherine Spokes
  • Ingrid A M Derks
  • Maiko Kondo

Detail Information

Publications85

  1. ncbi Notch signaling in the mammalian central nervous system: insights from mouse mutants
    Keejung Yoon
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:709-15. 2005
    ..These mutations have provided critical insight into Notch function in the CNS and have led to the identification of promising new directions that are likely to generate important discoveries in the future...
  2. pmc Notch signaling controls liver development by regulating biliary differentiation
    Yiwei Zong
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 136:1727-39. 2009
    ..These results reconcile previous conflicting reports about the role of Notch during liver development and suggest that Notch acts by coordinating biliary differentiation and morphogenesis...
  3. pmc Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages
    HASINA HAMILTON OUTTZ
    Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    J Immunol 185:4363-73. 2010
    ..had decreased expression of VEGFR-1 compared with macrophages from wild-type mice, whereas VEGFR-1 expression in Notch4(-/-) macrophages was normal...
  4. ncbi Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation
    Marina A Vorontchikhina
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA
    Gene Expr Patterns 5:701-9. 2005
    ..Here, we characterize the expression patterns of Notch1, Notch4, and Jagged1 proteins during the process of folliculogenesis and corpus luteum formation in the mouse ovary, an ..
  5. ncbi Coexpression of Cux-1 and Notch signaling pathway components during kidney development
    Madhulika Sharma
    Department of Anatomy and Cell Biology, and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Dev Dyn 231:828-38. 2004
    ..Taken together, these results suggest that Cux-1 may function in the context of the Notch signaling pathway in multiple tissues during mammalian embryogenesis...
  6. ncbi Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
    N Villa
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095 1737, USA
    Mech Dev 108:161-4. 2001
    ..Surprisingly, directed expression of a constitutively active form of Notch4 within mouse endothelial cells produces a similar vascular embryonic lethality...
  7. ncbi Characterization of Notch receptor expression in the developing mammalian heart and liver
    Kathleen M Loomes
    Division of Gastroenterology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med Genet 112:181-9. 2002
    ..JAG1 is also expressed in cells adjacent to those expressing Notch2, suggesting a possible ligand receptor relationship. The Notch receptors have distinct roles in cell fate determination in different organ systems...
  8. pmc Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease
    Patrick A Murphy
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, University of California, San Francisco, CA, USA
    Lab Invest 89:971-82. 2009
    ..We have previously shown that expression of constitutively-active Notch4 receptor in the endothelium elicits and maintains the hallmarks of BAVM in mice, thus establishing a mouse model ..
  9. ncbi Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion
    H Uyttendaele
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Biol 196:204-17. 1998
    ..The Notch4(int-3) mammary oncoprotein, an activated form of the Notch4 receptor, inhibited the branching morphogenesis ..
  10. pmc Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    Xiaofeng Zheng
    Departments of Cell and Molecular Biology and Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3368-73. 2008
    ..In conclusion, the data reveal posttranslational modification of the activated form of the Notch receptor and an intricate mode of cross-coupling between the Notch and hypoxia signaling pathways...
  11. pmc Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
    Carrie J Shawber
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 117:3369-82. 2007
    ..We found that Notch1 and Notch4 were expressed in normal and tumor lymphatic endothelial cells and that Notch1 was activated in lymphatic ..
  12. pmc Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
    H Uyttendaele
    Department of Pathology and Obstetrics Gynecology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:5643-8. 2001
    ..the role of Notch signaling in embryonic endothelium of the mouse by expressing an activated form of the Notch4 protein in vasculature under the regulation of the Flk1 (VEGFR) locus...
  13. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  14. ncbi Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
    H Uyttendaele
    Department of Pathology in the Center of Reproductive Sciences, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Development 122:2251-9. 1996
    ..We propose to name this gene Notch4 and reserve the int-3 nomenclature for references to the oncogenic form...
  15. ncbi Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Immunol 175:1062-72. 2005
    ..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene...
  16. pmc Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
    Vuk P Jovanovic
    Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
    Reprod Biol Endocrinol 11:43. 2013
    ..We hypothesized that blocking Notch pathways would disrupt follicular maturation in the mouse ovary...
  17. pmc Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis
    Preethi Vijayaraj
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Development 139:3973-85. 2012
    ..We show that Erg is required for the maintenance of the core EnMT regulatory factors that include Snail1 and Snail2 by binding to their promoter and intronic regions...
  18. pmc Notch controls the magnitude of T helper cell responses by promoting cellular longevity
    Christina Helbig
    Department of Cell Biology and Histology, Academic Medical Center, 1105AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:9041-6. 2012
    ..Our findings, therefore, show that Notch controls the magnitude of CD4(+) T-cell responses by promoting cellular longevity...
  19. pmc Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients
    Ryan Humphreys
    Department of Surgery, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 21:1374-83. 2012
    ..Future studies will investigate the mechanism in which Jagged1 acts in a cell autonomous and cell non-autonomous manner...
  20. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
    ..To assess the role of the Notch4 gene, we generated Notch4-deficient mice by gene targeting...
  21. ncbi The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
    Seungwoon Seo
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Dev Biol 294:458-70. 2006
    ..Taken together, our results demonstrate that Foxc transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development...
  22. ncbi Segmental expression of Notch and Hairy genes in nephrogenesis
    Linghong Chen
    Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Physiol Renal Physiol 288:F939-52. 2005
    ..These studies provide the basis for the future development of strategies to examine the role of individual effector molecules in the determination of the differentiation pattern of the nephron...
  23. ncbi Developmental expression of the Notch signaling pathway genes during mouse preimplantation development
    Sarah Cormier
    Unite de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Gene Expr Patterns 4:713-7. 2004
    ..We show that Notch1, 2, Jag1-2, Dll-3, Rbpsuh and Dtx2 transcripts are expressed at all stages. Notch4 and Dll-4 mRNAs are synthesized from the 2-cell through to the hatched blastocyst stage...
  24. ncbi The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions
    Patricia Hainaud
    Institut des Vaisseaux et du Sang, INSERM U689, IFR139, Paris VII Denis Diderot, Hopital Lariboisiere, Paris, France
    Cancer Res 66:8501-10. 2006
    ..In this study, we assessed the expression of DLL4, Notch4, and ephrin B2 in transgenic mice developing hepatocarcinoma characterized by a strong remodeling of the tumor ..
  25. ncbi Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice
    Takeo Kitamoto
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 331:1154-62. 2005
    ..We also surveyed the adult tissues of Notch3-/- mice and found significantly fewer thymocytes in 10-week-old mice. Therefore, the thymus might be a target tissue affected by Notch3 deficiency...
  26. pmc Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development
    Liam M Casey
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1830-44. 2006
    ....
  27. ncbi Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
  28. ncbi Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling
    Youping Sun
    The Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Oncogene 24:5365-74. 2005
    We present evidence that Notch4ICD attenuates TGF-beta signaling. Cells expressing the activated form of the Notch4 receptor (ICD4) were resistant to the growth-inhibitory effects of TGF-beta...
  29. pmc Critical role of endothelial Notch1 signaling in postnatal angiogenesis
    Kyosuke Takeshita
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Boston, MA, USA
    Circ Res 100:70-8. 2007
    ..Of the Notch receptors, only Notch1 and Notch4 are expressed in vascular endothelial cells...
  30. pmc Loss of Gata5 in mice leads to bicuspid aortic valve
    Brigitte Laforest
    Program in Molecular Biology, University of Montreal, Montreal, Quebec, Canada
    J Clin Invest 121:2876-87. 2011
    ..Mice with mutated Gata5 alleles represent unique models to dissect the mechanisms underlying degenerative aortic valve disease and to develop much-needed preventive and therapeutic interventions...
  31. pmc Trp53 regulates Notch 4 signaling through Mdm2
    Youping Sun
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    J Cell Sci 124:1067-76. 2011
    ....
  32. pmc Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression
    Matthew R Mysliwiec
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 286:17193-204. 2011
    ..The identification of Jarid2 as a potential regulator of Notch1 signaling has broad implications for many cellular processes including development, stem cell maintenance, and tumor formation...
  33. pmc Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7
    Donna Nichol
    Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA
    Blood 116:6133-43. 2010
    ..In conclusion, we have uncovered a critical role for Egfl7 in vascular development and have shown that some of these functions are mediated through modulation of Notch signaling...
  34. pmc Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease
    Yi Zhang
    Bone Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 117:299-308. 2011
    ..These results identify Notch as a novel essential regulator of pathogenic CD4(+) T-cell responses during acute GVHD and suggest that Notch signaling in T cells should be investigated as a therapeutic target after allogeneic HSCT...
  35. doi Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008
    ....
  36. ncbi Insertional mutation of int protooncogenes in the mammary tumors of a new strain of mice derived from the wild in China: normal- and tumor-tissue-specific expression of int-3 transcripts
    N H Sarkar
    Department of Immunology and Microbiology, Medical College of Georgia, Augusta 30912
    Virology 203:52-62. 1994
    ..4) a high percentage of the tumors (70%) had insertional mutations in int loci (Wnt-1, 26%; int-2, 13%; and int3, 43%); and (5) unlike Wnt-1 and int-2, a 5...
  37. doi The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    Monica Corada
    IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Dev Cell 18:938-49. 2010
    ..We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification...
  38. doi Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis
    Catarina Catela
    EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo RM, Italy
    Dev Dyn 239:2149-60. 2010
    ..These findings uncover a novel and essential function for SGK1 in cardiovascular development contributing to a better understanding of mammalian angiogenesis...
  39. pmc Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice
    Doug Miniati
    Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, San Francisco, CA 94143 0507, USA
    Am J Physiol Lung Cell Mol Physiol 298:L169-77. 2010
    ..Using a tetracycline-repressible system, we expressed constitutively active Notch4 (Notch4*) specifically in the endothelium of adult mice...
  40. doi Mouse mammary tumor virus derived from wild mice does not target Notch-4 protooncogene for the development of mammary tumors in inbred mice
    Nurul H Sarkar
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Virology 388:121-7. 2009
    ..Our findings may suggest, among other possibilities, the existence of a structural difference(s) between laboratory and wild mice at the Notch-4 locus that regulates the integration of Jyg-MMTV proviral DNA...
  41. pmc Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1
    Alex Robert-Moreno
    Centre Oncologia Molecular, IDIBELL, Gran Via km 2 7 Hospitalet, Barcelona, Spain
    EMBO J 27:1886-95. 2008
    ..Taken together, our results indicate that Jagged1-mediated activation of Notch1 is responsible for regulating GATA2 expression in the AGM, which in turn is essential for definitive haematopoiesis in the mouse...
  42. pmc Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation
    Jing Wu
    Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI 53706, USA
    Mol Cell Biol 27:2411-22. 2007
    The Notch signaling pathway modulates cell fate in diverse contexts, including vascular development. Notch4 is selectively expressed in vascular endothelium and regulates vascular remodeling...
  43. pmc Stepwise arteriovenous fate acquisition during mammalian vasculogenesis
    Diana C Chong
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Dev Dyn 240:2153-65. 2011
    ..Together, our results provide a first spatiotemporal analysis of mammalian AV cell fate establishment and anatomy, as well as a delineation of a molecular toolkit for analysis of arteries and veins during early vessel development...
  44. ncbi Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene
    Lizi Wu
    Department of Medical Oncology, Mayer 540, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Gene 328:153-65. 2004
    ..There seems to be close correlation of the spatial and temporal expression among Maml1, Notch1 and Hes1 in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis...
  45. pmc Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells
    J Robbins
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 66:2594-9. 1992
    ..Activation of expression of a recombinant int-3 genomic DNA fragment encoding the 2.3-kb RNA species in HC11 mouse mammary epithelial cells in vitro induces anchorage-independent growth in soft agar...
  46. pmc Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
    T Mizutani
    Department of Medical Chemistry and Department of Neurosurgery, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 98:9026-31. 2001
    ..These results demonstrate the conserved biochemical mechanism of signal transduction among mammalian Notch family members...
  47. ncbi Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system
    K Kusumi
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 100:141-4. 2001
    ..Transverse sections show that Dll3 is expressed in territories where commissural neurons are formed. We have also looked at neuronal patterning in the mid-hindbrain region in Dll3(pu) mutants...
  48. ncbi Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Development 127:3913-21. 2000
    ..Expression of Notch1, Notch2, Notch3 and Notch4 mRNAs in the mouse lung increased with age, and Notch1 mRNA was expressed in a Hes1-dependent manner...
  49. pmc A novel non-mouse mammary tumor virus activation of the Int-3 gene in a spontaneous mouse mammary tumor
    E C Kordon
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 69:8066-9. 1995
    ..This is the first demonstration that an insertional mutation unrelated to MMTV activates an Int gene commonly associated with mammary tumorigenesis...
  50. ncbi Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
    A K Lewis
    Department of Neuroscience, Genentech, Inc, South, San Francisco, CA 94080, USA
    Mech Dev 78:159-63. 1998
    ..Their expression persists into adult. Notch2, Notch3, Notch4, and Delta1 are excluded from the inner ear epithelia...
  51. ncbi Somatic mutations that contribute to breast cancer
    R Callahan
    Oncogenetics Section, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem Soc Symp 63:211-21. 1998
    ..Using this approach we have identified two genes, designated NOTCH4/INT3 and INT6 respectively...
  52. ncbi Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis
    Y Shirayoshi
    Mammalian Development Laboratory, National Institute of Genetics, Mishima, Japan
    Genes Cells 2:213-24. 1997
    ..However, the exact nature and the in vivo expression pattern of the int-3 proto-oncogene are unknown. The function of gene products in embryogenesis is also not clear...
  53. pmc Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Proc Natl Acad Sci U S A 93:9096-101. 1996
    ..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC...
  54. ncbi Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis
    D Gallahan
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 56:1775-85. 1996
    Insertional mutation of the Int3 gene, a member of the Notch gene family, is frequently associated with primary mouse mammary tumors induced by the mouse mammary tumor virus (MMTV)...
  55. ncbi Clonal variations among multiple primary mammary tumors and within a tumor of individual mice: insertion mutations of int oncogenes
    N H Sarkar
    Department of Medicine, Medical College of Georgia, Augusta 30912 2400, USA
    Virology 212:490-9. 1995
    ....
  56. ncbi Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development
    G H Smith
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892 1750, USA
    Cell Growth Differ 6:563-77. 1995
    b>INT3 is interrupted by retroviral DNA insertion in approximately 18% of primary Czech mouse mammary tumors induced by mouse mammary tumor virus. One consequence of these insertions is the production of a 2...
  57. ncbi Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2
    C Dickson
    Cell 37:529-36. 1984
    ..Since the RNA is not detected in normal mammary tissue, we conclude that MMTV integration activates the expression of a cellular gene within int-2 and that this event may contribute to tumorigenesis...
  58. pmc A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17
    D Gallahan
    J Virol 61:218-20. 1987
    ....
  59. ncbi Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks
    M Prochazka
    Jackson Laboratory, Bar Harbor, ME 04609
    Diabetes 38:1446-55. 1989
    ..abstract truncated at 400 words)..
  60. ncbi Evolutionary analysis of vertebrate Notch genes
    R D Kortschak
    Discipline of Genetics, Department of Molecular Bioscience, Adelaide University, North Terrace, Adelaide 5005, Australia
    Dev Genes Evol 211:350-4. 2001
    ..There is also evidence that the mouse Notch4 gene is the result of a rapid divergence from a Notch3-like gene...
  61. ncbi Notch gene expression during pancreatic organogenesis
    E Lammert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mech Dev 94:199-203. 2000
    ..Notch 3 and Notch 4 are expressed in pancreatic mesenchyme and later in endothelial cells. Together these descriptive data comprise a framework for understanding the cellular basis for Notch function during pancreatic development...
  62. pmc Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
    Michael T Tetzlaff
    Department of Human and Molecular Genetics, Texas Children s Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:3338-45. 2004
    ..These data suggest essential functions for Fbw7 in controlling cyclin E and Notch signaling pathways in the mouse...
  63. ncbi Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions
    Yuji Seta
    Department of Cellular and Structural Biology and the Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Comp Neurol 464:49-61. 2003
    ..Similarly, Notch gene expression in adult taste buds suggests continued roles in cell lineage determination and cell turnover...
  64. ncbi Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
    Cornelia Leimeister
    Theodor Boveri Institute, Biozentrum, Physiological Chemistry I, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany
    Gene Expr Patterns 3:595-8. 2003
    ..Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules...
  65. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..Thus, biliary epithelium has the potential for pancreatic differentiation and Hes1 determines biliary organogenesis by preventing the pancreatic differentiation program, probably by directly repressing transcription of Neurog3...
  66. pmc The distribution of Notch receptors and their ligands during articular cartilage development
    A J Hayes
    Cardiff School of Biosciences, Cardiff University, PO Box 911 Museum Avenue, Cardiff, UK
    J Anat 202:495-502. 2003
    ..Mechanisms by which these processes are controlled are discussed in light of recent advances in the understanding of Notch signalling pathways...
  67. pmc A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development
    Takamune Takahashi
    Nephrology Division and Center for Vascular Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:1817-31. 2003
    ..These findings implicate a member of the receptor tyrosine phosphatase family, CD148, in developmental vascular organization and provide evidence that it regulates endothelial proliferation and endothelium-pericyte interactions...
  68. ncbi Notch1 and Jagged1 expression by the developing pulmonary vasculature
    Darren B Taichman
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Dev Dyn 225:166-75. 2002
    ..These temporal and spatial patterns in Notch1/Jagged1 gene and protein expression suggest multiple potential paths of cell-cell signaling during lung development and vascular morphogenesis...
  69. ncbi Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad
    Jennifer Brennan
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 244:418-28. 2002
    ..This newly formed arterial system establishes a new pattern of blood flow in the XY gonad, which we speculate may have an important role in export of testosterone to masculinize the XY embryo...
  70. ncbi Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
    Roi Gazit
    Cell and Animal Biology, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Development 131:903-13. 2004
    ..However, Math1-null rhombic lip cells presented conspicuous downregulation of Notch4 and Dll1...
  71. ncbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    Q Yang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 294:2155-8. 2001
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  72. ncbi Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25
    Suk Keun Lee
    Department of Oral Pathology, College of Dentistry, Kangnung National University, Kangnung 210 702, South Korea
    Genomics 83:243-53. 2004
    ..These results suggest that Krox-25 plays an important role as a transcription factor for the cytodifferentiation and amelogenesis of enamel epithelium...
  73. pmc Peroxisome-proliferator-activated receptor-binding protein (PBP) is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression
    Yiwei Tony Zhu
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U S A
    Biochem J 425:435-44. 2010
    ..We established a mammary epithelial cell line with a genotype of PBPLoxP/LoxP by expressing an active form of Notch4. Null mutation of PBP caused severe growth inhibition of the Notch4-immortalized mammary cells...
  74. ncbi The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome
    S Miyazaki
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Genomics 27:420-4. 1995
    ....
  75. pmc Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
    D Gallahan
    J Virol 61:66-74. 1987
    ..This region of the cellular genome was designated int-3 since it is unrelated to the int-1 and int-2 loci. The int-3 locus does not appear to correspond to other proto-oncogenes but is well conserved among mammalian species...
  76. pmc Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
    Timothy R Carlson
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery and Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:9884-9. 2005
    ..We expressed a constitutively active Notch4, int3, in the adult mouse endothelium by using the tetracycline-repressible system to suppress int3 during ..
  77. ncbi Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud
    Jeffrey C Francis
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK
    Dev Dyn 234:1006-15. 2005
    ..Regulation of the extent of the AER is achieved by Notch signalling positively regulating apoptosis in the AER. We also demonstrate that Notch1 is not required for proper formation of all the derivatives of the limb mesenchyme...
  78. ncbi Genetic contributions of nonautoimmune SWR mice toward lupus nephritis
    S Xie
    Simmon s Arthritis Research Center and Center for Immunology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    J Immunol 167:7141-9. 2001
    ..In conclusion, lupus in the SNF(1) strain is truly polygenic, with at least four dominant contributions from the SWR strain. The immunological functions and molecular identities of these loci await elucidation...
  79. pmc Coronary arteries form by developmental reprogramming of venous cells
    Kristy Red-Horse
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford, California 94305 5307, USA
    Nature 464:549-53. 2010
    ..Understanding this new reprogramming process and identifying the endogenous signals should suggest more natural ways of engineering coronary bypass grafts and revascularizing the heart...
  80. ncbi Expression of Notch pathway components in fetal and adult mouse small intestine
    Natalia Schröder
    Institut für Molekularbiologie OE5250, Medizinische Hochschule Hannover, Carl Neubergstrasse 1, D 30625 Hannover, Germany
    Gene Expr Patterns 2:247-50. 2002
    ....
  81. ncbi Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes
    Vincent E Sollars
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 17:808-21. 2006
    ..Given the importance of this cell compartment in leukemia progression and the soon to be released genomic sequence of 15 mouse strains, these differences may provide a valuable tool for research into leukemia...
  82. pmc Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis
    A Raafat
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 28:219-30. 2009
    ..b>Notch4 signaling is mediated primarily through the interaction of Int3 with the transcription repressor/activator Rbpj...
  83. ncbi Recombination in the class III region of the mouse major histocompatibility complex
    M Yoshino
    Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
    Immunogenetics 40:280-6. 1994
    ..11 DNA markers; these included Tnx, the gene for an extracellular matrix protein, tenascin X, the Notch-related Int3 gene, and a microsatellite marker, D17Mit13, none of which had previously been mapped precisely...
  84. ncbi Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
    M T Saxena
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Biol Chem 276:40268-73. 2001
    Oncogenic forms of Notch1, Notch2, and Notch4 appear to mimic signaling intermediates of Notch1 and suggest that the role of proteolysis in Notch signaling has been conserved...
  85. ncbi Functional conservation of mouse Notch receptor family members
    H Kato
    Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Sakyo ku, Japan
    FEBS Lett 395:221-4. 1996
    ..mNotch2, mNotch3 and int3 (= mNotch4) were shown to interact with RBP-Jkappa by the GST-fusion pull down assay and dominant negative ..

Research Grants1

  1. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..