Notch3

Summary

Gene Symbol: Notch3
Description: notch 3
Alias: AW229011, hpbk, Notch gene homolog 3, neurogenic locus notch homolog protein 3
Species: mouse

Top Publications

  1. pmc Notch3 signaling promotes the development of pulmonary arterial hypertension
    Xiaodong Li
    University of California San Diego, La Jolla, CA, USA
    Nat Med 15:1289-97. 2009
  2. pmc Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
    Valérie Domenga
    INSERM E365, Faculté de Médecine Lariboisiere, Paris 75010, France
    Genes Dev 18:2730-5. 2004
  3. ncbi Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nature 383:707-10. 1996
  4. pmc YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation
    Thomas Rauen
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Biol Chem 284:26928-40. 2009
  5. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
  6. pmc Notch3 is critical for proper angiogenesis and mural cell investment
    Hua Liu
    National Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
    Circ Res 107:860-70. 2010
  7. ncbi Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression
    Simone Kennard
    Vascular Biology Center and Department of Obstetrics and Gynecology, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    J Biol Chem 283:1324-33. 2008
  8. pmc Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries
    E J Belin de Chantemèle
    INSERM U 771, Angers, France
    Arterioscler Thromb Vasc Biol 28:2216-24. 2008
  9. pmc Smooth muscle Notch1 mediates neointimal formation after vascular injury
    Yuxin Li
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 119:2686-92. 2009
  10. doi Notch3 is essential for regulation of the renal vascular tone
    Nada Boulos
    INSERM UMR702, Paris, France
    Hypertension 57:1176-82. 2011

Research Grants

Scientific Experts

  • Mitsuru Morimoto
  • Vuk P Jovanovic
  • Thao P Dang
  • Muriel Davisson
  • Anne Joutel
  • Yi Zhang
  • Norio Yamamoto
  • Hiroki Yamanaka
  • L A Milner
  • T Ito
  • K Kusumi
  • Shadmehr Demehri
  • Yuzo Kadokawa
  • Z Jiao
  • Darren B Taichman
  • Annika E Wallberg
  • Denis Houzelstein
  • Lizi Wu
  • Tino D Piscione
  • Thomas Gridley
  • Joseph F Arboleda-Velasquez
  • Urban Lendahl
  • Sonja Djudjaj
  • Isabella Screpanti
  • Luigi Frati
  • Alberto Gulino
  • Simone Kennard
  • T A Mitsiadis
  • Alessandra Vacca
  • Diana Bellavia
  • D Bellavia
  • Brenda Lilly
  • Hua Liu
  • Yonghua Pan
  • Freddy Radtke
  • Hannu Kalimo
  • U Lendahl
  • Antonio F Campese
  • Claudio Talora
  • Raphael Kopan
  • Heather A Mason
  • M P Felli
  • Keejung Yoon
  • Qingqing Wang
  • Ryan Humphreys
  • Jeffrey Gagan
  • Dominique Guerrot
  • Christos Chatziantoniou
  • Jean Claude Dussaule
  • Apostolos Klinakis
  • Paolo E Forni
  • Shengxi Wu
  • Goedele Wallays
  • Shamik Ghosh
  • Heather Fairfield
  • Alessandro Barbarulo
  • Nada Boulos
  • Peter R Mertens
  • Ute Raffetseder
  • Luke T Krebs
  • Konrad Urbanek
  • Keli Xu
  • Robin Jeannet
  • Iara D Carbery
  • M Lardelli
  • Cenk Ayata
  • Michael A Moskowitz
  • Angeliki Louvi
  • Saara Tikka
  • Spyros Artavanis-Tsakonas
  • Yiwei Zong
  • Hong Soon Kang
  • Paola Grazioli
  • K L Hahn
  • Xiaodong Li
  • Thomas Rauen
  • Yuxin Li
  • Achim Gossler
  • A F Campese
  • A Gulino
  • Giuseppina Di Mario
  • I Screpanti
  • Maria Pia Felli
  • James K Liao
  • Xiaofeng Zheng
  • Steve Rodriguez
  • Maciej Jurynczyk
  • Shaobo Jin
  • Shuting Bai
  • E J Belin de Chantemèle

Detail Information

Publications107 found, 100 shown here

  1. pmc Notch3 signaling promotes the development of pulmonary arterial hypertension
    Xiaodong Li
    University of California San Diego, La Jolla, CA, USA
    Nat Med 15:1289-97. 2009
    ..Here we show that human pulmonary hypertension is characterized by overexpression of NOTCH3 in small pulmonary artery smooth muscle cells and that the severity of disease in humans and rodents correlates ..
  2. pmc Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
    Valérie Domenga
    INSERM E365, Faculté de Médecine Lariboisiere, Paris 75010, France
    Genes Dev 18:2730-5. 2004
    Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle ..
  3. ncbi Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nature 383:707-10. 1996
    ..We have previously mapped the mutant gene to chromosome 19. Here we report the characterization of the human Notch3 gene which we mapped to the CADASIL critical region...
  4. pmc YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation
    Thomas Rauen
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Biol Chem 284:26928-40. 2009
    ....
  5. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
    ..A similar defect was observed in Notch2(beta-geo/+)Notch3(beta-geo/beta-geo) compound mutant mice but not in Notch2(beta-geo/+) or Notch3(beta-geo/beta-geo) single mutants...
  6. pmc Notch3 is critical for proper angiogenesis and mural cell investment
    Hua Liu
    National Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
    Circ Res 107:860-70. 2010
    ..Yet, the molecular mechanisms underlying their association have not been fully defined...
  7. ncbi Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression
    Simone Kennard
    Vascular Biology Center and Department of Obstetrics and Gynecology, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    J Biol Chem 283:1324-33. 2008
    ..Using TGF-beta1 to induce the differentiation of 10T1/2 fibroblasts, we investigated the specific function of Notch3. Overexpression of activated Notch3 caused repression of TGF-beta1-induced smooth muscle-specific genes, whereas ..
  8. pmc Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries
    E J Belin de Chantemèle
    INSERM U 771, Angers, France
    Arterioscler Thromb Vasc Biol 28:2216-24. 2008
    b>Notch3, a member of the evolutionary conserved Notch receptor family, is primarily expressed in vascular smooth muscle cells...
  9. pmc Smooth muscle Notch1 mediates neointimal formation after vascular injury
    Yuxin Li
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 119:2686-92. 2009
    ..However, the pathophysiological role of Notch1 in the postnatal period is not known. We hypothesize that Notch1 signaling in vascular smooth muscle cells (SMCs) may contribute to neointimal formation after vascular injury...
  10. doi Notch3 is essential for regulation of the renal vascular tone
    Nada Boulos
    INSERM UMR702, Paris, France
    Hypertension 57:1176-82. 2011
    The Notch3 receptor participates in the development and maturation of vessels. Mutations of Notch3 in humans are associated with defective regulation of cerebral blood flow...
  11. ncbi Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
    Johan Lundkvist
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genesis 41:13-22. 2005
    ..We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans...
  12. pmc Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate
    T A Mitsiadis
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Cell Biol 130:407-18. 1995
    ..These data suggest that Notch genes may be involved in mediating some of the biological effects of retinoic acid during normal development and after teratogenic exposure...
  13. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    ....
  14. pmc Linking Notch signaling to ischemic stroke
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:4856-61. 2008
    ....
  15. ncbi Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 37:139-43. 2003
    ..To analyze the in vivo role of the Notch3 gene in mice, we created a deletion allele by gene targeting...
  16. ncbi Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL
    Nilima Prakash
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Exp Cell Res 278:31-44. 2002
    ..These data show that Notch 3 expression is conserved between mouse and human and suggest that the mouse is a valid system for analysis of CADASIL...
  17. doi Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells
    Shaobo Jin
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Circ Res 102:1483-91. 2008
    Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunction...
  18. pmc Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity
    Shadmehr Demehri
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e123. 2008
    ..These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations...
  19. pmc Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:E128-35. 2011
    ..We determine that CADASIL pathophysiology is associated with hypomorphic Notch 3 function in vascular smooth muscle cells and implicate the accumulation of clusterin and collagen 18 α1/endostatin in brain vessel pathology...
  20. ncbi Characterization of Notch receptor expression in the developing mammalian heart and liver
    Kathleen M Loomes
    Division of Gastroenterology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med Genet 112:181-9. 2002
    ..In the newborn mouse liver, Notch2 and Notch3 are expressed in opposing cell populations, suggesting they play different roles in cell fate determination during ..
  21. ncbi Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
    M Lardelli
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 59:177-90. 1996
    ....
  22. ncbi The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
    M Lardelli
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 46:123-36. 1994
    ..Considering the predominantly early expression in CNS and its distinct structural features, the Notch 3 gene is likely to contribute significantly to vertebrate Notch function during CNS development...
  23. ncbi Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Development 127:3913-21. 2000
    ..Expression of Notch1, Notch2, Notch3 and Notch4 mRNAs in the mouse lung increased with age, and Notch1 mRNA was expressed in a Hes1-dependent manner...
  24. ncbi Defining brain wiring patterns and mechanisms through gene trapping in mice
    P A Leighton
    Howard Hughes Medical Institute and Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Nature 410:174-9. 2001
    ..Studies of two of these mouse lines have identified an in vivo guidance function for a vertebrate transmembrane semaphorin, Sema6A, and have helped re-evaluate that of the Eph receptor EphA4...
  25. ncbi Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development
    M P Felli
    Department of Experimental Medicine, University of L Aquila, Aquila 67100, Italy
    Int Immunol 11:1017-25. 1999
    ..Moreover, a differential distribution of Notch3, with respect to Notch1, was observed in distinct age-related thymocyte subsets...
  26. ncbi The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
    C Larsson
    Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden
    Genomics 24:253-8. 1994
    ..2-p13.1, respectively, which are regions of neoplasia-associated translocation...
  27. pmc Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing
    Diana Bellavia
    Department of Experimental Medicine, University La Sapienza, Roma, Italy
    EMBO J 26:1670-80. 2007
    Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell ..
  28. pmc Canonical notch signaling functions as a commitment switch in the epidermal lineage
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 20:3022-35. 2006
    ....
  29. ncbi Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice
    Takeo Kitamoto
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 331:1154-62. 2005
    The Notch3 gene, a member of the Notch gene family, is expressed in a wide variety of tissues during development. We generated and analyzed Notch3-deficient mice to assess the in vivo role of the Notch3 gene...
  30. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  31. ncbi gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 7:731-43. 2004
    ....
  32. pmc Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice
    D Bellavia
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, Italy
    EMBO J 19:3337-48. 2000
    ..b>Notch3 is expressed in CD4(-)8(-) thymocytes and is down-regulated across the CD4(-)8(-) to CD4(+)8(+) transition, ..
  33. ncbi Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 286:472-82. 2005
    ..Thus, Notch signaling plays a non-autonomous role in digit septation...
  34. ncbi NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    Shuting Bai
    Departments of Pathology and Immunology, Molecular Biology and Pharmacology, and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:6509-18. 2008
    ..Although NOTCH1 and NOTCH3 collaborate in regulating osteoclast formation, NOTCH1 is the dominant paralog...
  35. doi Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Goedele Wallays
    Vesalius Research Center, Flanders Institute for Biotechnology VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 31:2881-8. 2011
    ..and leukoencephalopathy (CADASIL) is an adult-onset neurovascular disorder caused by stereotyped mutations in the NOTCH3 receptor...
  36. ncbi Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
    T A Mitsiadis
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Development 124:1473-83. 1997
    ..This indicates that, at least during tooth development, the expression patterns observed for receptors and ligands in the Notch signaling pathway are generated by different induction mechanisms...
  37. pmc Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts
    Jeffrey Gagan
    Department of Biochemistry and Molecular Genetics, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Biol Chem 287:40360-70. 2012
    b>Notch3 is expressed in myogenic precursors, but its function is not well known.
  38. doi Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury
    Sonja Djudjaj
    Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Pathol 228:286-99. 2012
    ..Thus, specific blockade of this receptor may be suitable as therapeutic option to delay progression of kidney disease...
  39. pmc Notch2 and Notch3 function together to regulate vascular smooth muscle development
    Qingqing Wang
    Center for Cardiovascular and Pulmonary Research, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 7:e37365. 2012
    ..Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only mild defects in ..
  40. pmc Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    Xiaofeng Zheng
    Departments of Cell and Molecular Biology and Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3368-73. 2008
    ..In conclusion, the data reveal posttranslational modification of the activated form of the Notch receptor and an intricate mode of cross-coupling between the Notch and hypoxia signaling pathways...
  41. pmc Mutation discovery in mice by whole exome sequencing
    Heather Fairfield
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Genome Biol 12:R86. 2011
    ..We found strong candidate mutations for the majority of mutant exomes sequenced, including new models of orofacial clefting, urogenital dysmorphology, kyphosis and autoimmune hepatitis...
  42. pmc Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients
    Ryan Humphreys
    Department of Surgery, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 21:1374-83. 2012
    ..Future studies will investigate the mechanism in which Jagged1 acts in a cell autonomous and cell non-autonomous manner...
  43. ncbi Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis
    Claudio Talora
    Dipartimento di Medicina Sperimentale e Patologia, University La Sapienza, Viale Regina Elena 32400161 Roma, Italy
    Blood 107:3313-20. 2006
    ..However, specific target genes and molecular partners are not fully elucidated. We show that Notch3 activation sustains aberrant SCL/Tal1 overexpression and phosphorylation in mature thymocytes...
  44. pmc Notch signaling in bulge stem cells is not required for selection of hair follicle fate
    Shadmehr Demehri
    Department of Developmental Biology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 136:891-6. 2009
    ..Taken together, our findings yield detailed insight into the function of Notch signaling in hair follicle stem cells and reveal the mechanism of the replacement of Notch-deficient adult hair follicles by epidermal cysts...
  45. pmc Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia
    Alessandra Vacca
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, Italy
    EMBO J 25:1000-8. 2006
    ..is required for thymocytes proliferation and leukemogenesis, it is dispensable for thymocyte differentiation in Notch3-transgenic mice...
  46. ncbi Notch3 signaling initiates choroid plexus tumor formation
    L Dang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 25:487-91. 2006
    b>Notch3 has been studied in the context of brain development, but whether it plays a role in the formation of brain tumors is unclear...
  47. pmc Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
    Robin Jeannet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Blood 116:5443-54. 2010
    ..Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how these receptors contribute to T-cell transformation in ..
  48. ncbi Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
    ..1 (a region of conserved synteny to mouse Chromosome 5). In addition, we also found multiple SRPK-related sequences on other human chromosomes, one of which appears to correspond to a SRPK2 pseudogene on human chromosome 8...
  49. ncbi Notch3 signaling promotes radial glial/progenitor character in the mammalian telencephalon
    Louis Dang
    Institute for Cell Engineering, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Neurosci 28:58-69. 2006
    ..In light of studies suggesting that Notch3 can antagonize Notch1, we tested the effects of activated Notch3 (NICD3) in the mouse telencephalon...
  50. pmc Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression
    Hong Soon Kang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 29:6366-79. 2009
    ..In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function...
  51. ncbi Functional conservation of mouse Notch receptor family members
    H Kato
    Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Sakyo ku, Japan
    FEBS Lett 395:221-4. 1996
    ..These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP-Jkappa...
  52. pmc Targeted genome modification in mice using zinc-finger nucleases
    Iara D Carbery
    Sigma Advanced Genetic Engineering Labs, Sigma Aldrich Biotechnology, St Louis, MO 63146, USA
    Genetics 186:451-9. 2010
    ..Three individual genes, multidrug resistant 1a (Mdr1a), jagged 1 (Jag1), and notch homolog 3 (Notch3), were targeted in FVB/N and C57BL/6 mice...
  53. pmc Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart
    Konrad Urbanek
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:429-41. 2010
    ..Physiological hypertrophy in the developing heart has been considered the product of an increase in volume of preexisting fetal cardiomyocytes in the absence of myocyte formation...
  54. pmc Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium
    Steve Rodriguez
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 314:40-58. 2008
    ..Surprisingly, expression of Notch3 is also down-regulated...
  55. pmc The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression
    Junling Jia
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:7236-47. 2007
    ..We found that the Notch effector Herp2 is expressed in lens epithelium and directly suppresses p57Kip2 expression, providing a molecular link between Notch signaling and the cell cycle control machinery during lens development...
  56. ncbi Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
    K Shimizu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655 Japan
    J Biol Chem 274:32961-9. 1999
    ..Finally, solid-phase binding assay showed that Jagged1 binds to Notch1 and Notch3 in addition to Notch2, suggesting that mJagged1 is a ligand for multiple Notch receptors.
  57. pmc Notch signaling maintains Leydig progenitor cells in the mouse testis
    Hao Tang
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3745-53. 2008
    ....
  58. ncbi Expression of Apc2 during mouse development
    Hiroki Yamanaka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Brain Res Gene Expr Patterns 1:107-14. 2002
    ..During development of cortex, retina and cerebellum, Apc2 is expressed in post-mitotic cells. These findings suggest that Apc2 may contribute to the development of neuronal cells...
  59. ncbi Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
    Emanuela Anastasi
    Department of Clinical Sciences, University La Sapienza, Rome, Italy
    J Immunol 171:4504-11. 2003
    ..In this study, we demonstrate that Notch3 expression is a characteristic feature of CD4(+)CD25(+) cells...
  60. ncbi Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
    Cornelia Leimeister
    Theodor Boveri Institute, Biozentrum, Physiological Chemistry I, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany
    Gene Expr Patterns 3:595-8. 2003
    ..Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules...
  61. doi Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription
    Alessandro Barbarulo
    Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy
    J Immunol 186:6199-206. 2011
    b>Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression of Foxp3, in cooperation with the pTα/pre-TCR pathway...
  62. ncbi Notch gene expression during pancreatic organogenesis
    E Lammert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mech Dev 94:199-203. 2000
    ..Notch 3 and Notch 4 are expressed in pancreatic mesenchyme and later in endothelial cells. Together these descriptive data comprise a framework for understanding the cellular basis for Notch function during pancreatic development...
  63. pmc Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4
    Denis Houzelstein
    Laboratory of Mammalian Development, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Mol Cell Biol 22:3794-802. 2002
    ..Natl. Acad. Sci. USA 95:8538-8543, 1998) and the Brd4 mutant phenotype is discussed in light of this result. Together, our results provide the first genetic evidence for an in vivo role in mammals for a member of the Fsh/Brd family...
  64. ncbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    Q Yang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 294:2155-8. 2001
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  65. ncbi Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression
    T A Mitsiadis
    Faculté d Odontologie, Universite de la Mediterranee, 13385 cedex 05, Marseille, France
    Mech Dev 109:399-403. 2001
    ..e. neuronal tissues) or to cell proliferation events (i.e. eye, vascular structures, hematopoiesis)...
  66. ncbi Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice
    G Dirami
    Department of Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Androl 22:944-52. 2001
    ..Key words: Cell fate, delta, jagged, presenilin, spermatogenesis...
  67. ncbi Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
    M T Saxena
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Biol Chem 276:40268-73. 2001
    ..Despite a high degree of structural homology and the presenilin-dependent activity of truncated Notch proteins, the extent that this reflects functional redundancy is unknown...
  68. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..Thus, biliary epithelium has the potential for pancreatic differentiation and Hes1 determines biliary organogenesis by preventing the pancreatic differentiation program, probably by directly repressing transcription of Neurog3...
  69. pmc A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    Apostolos Klinakis
    Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Nature 473:230-3. 2011
    ..Our studies identify a novel role for Notch signalling during early haematopoietic stem cell differentiation and suggest that the Notch pathway can play both tumour-promoting and -suppressive roles within the same tissue...
  70. doi Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon
    Shengxi Wu
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556 Japan
    Development 138:2499-509. 2011
    ..IPGNs are maintained in the neocortex and may act as progenitors for adult neurogenesis...
  71. pmc Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)- and Th17-type expansion involving Notch3 and Delta-like1
    Z Jiao
    Central Laboratory, Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University Pathogenic Biology Immunology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang Department of Laboratory Medicine, Jiangyin People s Hospital, Jiangyin, China
    Clin Exp Immunol 164:66-71. 2011
    ..The mRNA level of Notch3 was also up-regulated significantly, while the levels of the other three Notch receptors were not increased...
  72. ncbi Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud
    Jeffrey C Francis
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK
    Dev Dyn 234:1006-15. 2005
    ..Regulation of the extent of the AER is achieved by Notch signalling positively regulating apoptosis in the AER. We also demonstrate that Notch1 is not required for proper formation of all the derivatives of the limb mesenchyme...
  73. ncbi Notch/Delta expression in the developing mouse lung
    L C Post
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mech Dev 98:95-8. 2000
    ..Here, we report the localization of transcripts of several genes encoding members of the Notch/Delta pathway in the early mouse lung. Most genes are expressed in specific populations and so may contribute to cell diversification...
  74. ncbi Developmental expression of the Notch signaling pathway genes during mouse preimplantation development
    Sarah Cormier
    Unite de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Gene Expr Patterns 4:713-7. 2004
    ..Notch4 and Dll-4 mRNAs are synthesized from the 2-cell through to the hatched blastocyst stage. Notch3, Dll-1 and Dtx1exhibit a stage dependent expression as their mRNAs are detected in 2-cell embryos and in hatched ..
  75. pmc Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery
    Shamik Ghosh
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:22678-87. 2011
    b>Notch3 signaling is fundamental for arterial specification of systemic vascular smooth muscle cells (VSMCs). However, the developmental role and signaling properties of the Notch3 receptor in the mouse pulmonary artery remain unknown...
  76. ncbi Notch expression in developing olfactory neuroepithelium
    Kiyoshi Doi
    Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kusunoki cho 7 5 1, Chuo Ku, Kobe 650 0017, Japan
    Neuroreport 15:945-7. 2004
    ..During the developmental stage, Notch1 was mainly observed around the basal membrane, while Notch3 was observed in the lower compartment of the olfactory neuroepithelium...
  77. ncbi Functional diversity of notch family genes in fetal lung development
    Yanping Kong
    Brigham and Women s Hospital, Dept of Pathology, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1075-83. 2004
    ..Cumulatively, these observations suggest that interactions between distinct Notch family members can have diverse tissue-specific regulatory functions during development, arguing against simple functional redundancy...
  78. pmc Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
    Michael T Tetzlaff
    Department of Human and Molecular Genetics, Texas Children s Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:3338-45. 2004
    ..These data suggest essential functions for Fbw7 in controlling cyclin E and Notch signaling pathways in the mouse...
  79. pmc Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
    T Mizutani
    Department of Medical Chemistry and Department of Neurosurgery, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 98:9026-31. 2001
    ..These results demonstrate the conserved biochemical mechanism of signal transduction among mammalian Notch family members...
  80. pmc p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
    Annika E Wallberg
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 22:7812-9. 2002
    ....
  81. pmc Notch signaling controls liver development by regulating biliary differentiation
    Yiwei Zong
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 136:1727-39. 2009
    ..These results reconcile previous conflicting reports about the role of Notch during liver development and suggest that Notch acts by coordinating biliary differentiation and morphogenesis...
  82. ncbi Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway
    H Nakayama
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Genet 21:21-30. 1997
    ..These data suggest that Notch signaling through activation of HES transcriptional repressors may play a role in murine placental development...
  83. ncbi Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
    A K Lewis
    Department of Neuroscience, Genentech, Inc, South, San Francisco, CA 94080, USA
    Mech Dev 78:159-63. 1998
    ..Their expression persists into adult. Notch2, Notch3, Notch4, and Delta1 are excluded from the inner ear epithelia...
  84. ncbi Segmental expression of Notch and Hairy genes in nephrogenesis
    Linghong Chen
    Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Physiol Renal Physiol 288:F939-52. 2005
    ..These studies provide the basis for the future development of strategies to examine the role of individual effector molecules in the determination of the differentiation pattern of the nephron...
  85. ncbi Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis
    Tino D Piscione
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, Ont, Canada M5G 1X8
    Gene Expr Patterns 4:707-11. 2004
    ..Consequently, the differential, spatial regulation of Hes1 and Hes5 gene expression by the Notch signaling pathway in developing nephrons may be a mechanism for patterning cell fate decisions during nephron morphogenesis...
  86. ncbi Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene
    Lizi Wu
    Department of Medical Oncology, Mayer 540, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Gene 328:153-65. 2004
    ..There seems to be close correlation of the spatial and temporal expression among Maml1, Notch1 and Hes1 in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis...
  87. ncbi Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
    Roi Gazit
    Cell and Animal Biology, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Development 131:903-13. 2004
    ..Taken together, our data demonstrate that CGC differentiation, but not specification, depends on Math1, which acts by regulating the level of multiple components of the Notch signaling pathway...
  88. ncbi Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression
    L T Raetzman
    Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Dev Biol 265:329-40. 2004
    ..Notch2, Notch3, and Dll1 are initially expressed by most cells within the pituitary primordium and become restricted to a subset ..
  89. ncbi Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
    C Leimeister
    Institute of Physiological Chemistry I, Theodor Boveri Institute Biocenter, University of Wuerzburg, Am Hubland, D 97074, Wuerzburg, Germany
    Mech Dev 98:175-8. 2000
    ..Furthermore, HeyL expression in vascular smooth muscle cells and in the thymus strikingly overlaps with that of Notch3, mutations of which underlie the CADASIL vascular disorder.
  90. ncbi Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions
    Yuji Seta
    Department of Cellular and Structural Biology and the Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Comp Neurol 464:49-61. 2003
    ..Similarly, Notch gene expression in adult taste buds suggests continued roles in cell lineage determination and cell turnover...
  91. ncbi Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice
    Thao P Dang
    Division of Hematology and Medical Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
    Oncogene 22:1988-97. 2003
    b>Notch3 is a transmembrane receptor and a member of the Notch signaling pathway essential for cellular differentiation in a variety of developing tissues in both invertebrates and vertebrates...
  92. ncbi Chimeric analysis of Notch2 function: a role for Notch2 in the development of the roof plate of the mouse brain
    Yuzo Kadokawa
    Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Dev Dyn 225:126-34. 2002
    ..These results indicate that Notch2 plays an important role in development of the roof plate of the diencephalon and mesencephalon, and suggest that cellular rearrangement is involved in this process...
  93. ncbi CADASIL mutations impair Notch3 glycosylation by Fringe
    Joseph F Arboleda-Velasquez
    Neurology Department, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:1631-9. 2005
    Mutations in the NOTCH3 gene trigger adult-onset stroke and vascular dementia in patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)...
  94. ncbi Notch signaling in the mammalian central nervous system: insights from mouse mutants
    Keejung Yoon
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:709-15. 2005
    ..These mutations have provided critical insight into Notch function in the CNS and have led to the identification of promising new directions that are likely to generate important discoveries in the future...
  95. ncbi Loss of notch activity in the developing central nervous system leads to increased cell death
    Heather A Mason
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Dev Neurosci 28:49-57. 2006
    ..of cells in the nervous system, we have produced single and compound Notch conditional mutants in which Notch1 and Notch3 are removed at different times during brain development and in different populations of cells...
  96. doi A deficiency of lunatic fringe is associated with cystic dilation of the rete testis
    K L Hahn
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Reproduction 137:79-93. 2009
    ..Further, the dye studies demonstrated that many lunatic fringe mutant males had partial blocks of the connection between the rete testis and the efferent ducts bilaterally...
  97. doi Notch3: from subtle structural differences to functional diversity
    D Bellavia
    Laboratory of Molecular Pathology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    Oncogene 27:5092-8. 2008
    The Notch3 gene was identified, at the beginning of 90s, as the third mammalian Notch and was initially reported as being expressed in proliferating neuroepithelium...
  98. ncbi Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation
    T A Mitsiadis
    Faculté d Odontologie, Universite de la Mediterranee, Marseille Cedex 20, 13916, France
    Dev Biol 204:420-31. 1998
    ..The expression pattern of Delta1 in ameloblasts and odontoblasts is complementary to Notch1, Notch2, and Notch3 expression in adjacent epithelial and mesenchymal cells...
  99. pmc Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 19:1028-33. 2005
    ..in radial glia, and that BLBP expression is significantly reduced in the forebrains of mice lacking the Notch1 and Notch3 receptors...
  100. ncbi Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis
    Maciej Jurynczyk
    Department of Neurology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
    J Immunol 180:2634-40. 2008
    ..Specific induction of Notch1 and Notch3 transcripts were noted in PLP-reactive T cells upon Ag stimulation...
  101. ncbi Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk
    Nathalie Clement
    UMR 7079 de Physiologie et Physiopathologie, Universite Pierre et Marie Curie, CNRS, 7 quai Saint Bernard 75252 Paris, France
    J Cell Sci 120:3352-61. 2007
    ..Activation of the Notch pathway by the notch ligand Delta1, as well as overexpression of the active form of Notch3, prevents this phenomenon [initiated by interleukin 1beta (IL-1beta)], whereas inhibiting the Notch pathway ..

Research Grants2

  1. MOLECULAR CLONING OF A T(15;19) IN LUNG CANCER CELL LINE
    Thao Dang; Fiscal Year: 2005
    ..we demonstrated that the breakpoint on chromosome 19 lies approximately 40 kb upstream from the start site of Notch3, a member of the Notch proto- oncogene family...
  2. Notch3 signaling in small-artery-diseases
    Anne Joutel; Fiscal Year: 2009
    ..We will investigate effect of the archetypal R90C CADASIL mutation on NotchS wildtype activity in vivo using our Notch3R90C mice, NotchS null mice as a "rescue" system and transgenic RBP-JK reporter mice (Aim # 3). ..