Notch3

Summary

Gene Symbol: Notch3
Description: notch 3
Alias: AW229011, hpbk, neurogenic locus notch homolog protein 3, Notch gene homolog 3
Species: mouse

Top Publications

  1. pmc Notch3 signaling promotes the development of pulmonary arterial hypertension
    Xiaodong Li
    University of California San Diego, La Jolla, CA, USA
    Nat Med 15:1289-97. 2009
  2. pmc YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation
    Thomas Rauen
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Biol Chem 284:26928-40. 2009
  3. ncbi Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression
    Simone Kennard
    Vascular Biology Center and Department of Obstetrics and Gynecology, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    J Biol Chem 283:1324-33. 2008
  4. ncbi Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
    Johan Lundkvist
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genesis 41:13-22. 2005
  5. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
  6. ncbi The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
    C Larsson
    Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden
    Genomics 24:253-8. 1994
  7. ncbi The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
    M Lardelli
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 46:123-36. 1994
  8. pmc Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:E128-35. 2011
  9. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
  10. ncbi Complementary and combinatorial patterns of Notch gene family expression during early mouse development
    R Williams
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 53:357-68. 1995

Research Grants

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. pmc Notch3 signaling promotes the development of pulmonary arterial hypertension
    Xiaodong Li
    University of California San Diego, La Jolla, CA, USA
    Nat Med 15:1289-97. 2009
    ..Here we show that human pulmonary hypertension is characterized by overexpression of NOTCH3 in small pulmonary artery smooth muscle cells and that the severity of disease in humans and rodents correlates ..
  2. pmc YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation
    Thomas Rauen
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Biol Chem 284:26928-40. 2009
    ....
  3. ncbi Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression
    Simone Kennard
    Vascular Biology Center and Department of Obstetrics and Gynecology, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    J Biol Chem 283:1324-33. 2008
    ..Using TGF-beta1 to induce the differentiation of 10T1/2 fibroblasts, we investigated the specific function of Notch3. Overexpression of activated Notch3 caused repression of TGF-beta1-induced smooth muscle-specific genes, whereas ..
  4. ncbi Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
    Johan Lundkvist
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genesis 41:13-22. 2005
    ..We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans...
  5. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    ....
  6. ncbi The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
    C Larsson
    Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden
    Genomics 24:253-8. 1994
    ..2-p13.1, respectively, which are regions of neoplasia-associated translocation...
  7. ncbi The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
    M Lardelli
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 46:123-36. 1994
    ..Considering the predominantly early expression in CNS and its distinct structural features, the Notch 3 gene is likely to contribute significantly to vertebrate Notch function during CNS development...
  8. pmc Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:E128-35. 2011
    ..We determine that CADASIL pathophysiology is associated with hypomorphic Notch 3 function in vascular smooth muscle cells and implicate the accumulation of clusterin and collagen 18 α1/endostatin in brain vessel pathology...
  9. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  10. ncbi Complementary and combinatorial patterns of Notch gene family expression during early mouse development
    R Williams
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 53:357-68. 1995
    ..This expression pattern may be analogous to Notch expression in the peripheral nervous system of Drosophila, suggesting that mammalian Notch genes may also be involved in axonal pathfinding...
  11. ncbi Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nature 383:707-10. 1996
    ..We have previously mapped the mutant gene to chromosome 19. Here we report the characterization of the human Notch3 gene which we mapped to the CADASIL critical region...
  12. ncbi Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
    M Lardelli
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mech Dev 59:177-90. 1996
    ....
  13. ncbi Notch signalling controls pancreatic cell differentiation
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Nature 400:877-81. 1999
    ..A similar phenotype was observed in mice over-expressing neurogenin 3 (ngn 3) or the intracellular form of Notch3 (a repressor of Notch signalling)...
  14. pmc Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice
    D Bellavia
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, Italy
    EMBO J 19:3337-48. 2000
    ..b>Notch3 is expressed in CD4(-)8(-) thymocytes and is down-regulated across the CD4(-)8(-) to CD4(+)8(+) transition, ..
  15. ncbi Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Development 127:3913-21. 2000
    ..Expression of Notch1, Notch2, Notch3 and Notch4 mRNAs in the mouse lung increased with age, and Notch1 mRNA was expressed in a Hes1-dependent manner...
  16. ncbi Defining brain wiring patterns and mechanisms through gene trapping in mice
    P A Leighton
    Howard Hughes Medical Institute and Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Nature 410:174-9. 2001
    ..Studies of two of these mouse lines have identified an in vivo guidance function for a vertebrate transmembrane semaphorin, Sema6A, and have helped re-evaluate that of the Eph receptor EphA4...
  17. ncbi Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice
    G Dirami
    Department of Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Androl 22:944-52. 2001
    ..Key words: Cell fate, delta, jagged, presenilin, spermatogenesis...
  18. ncbi Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL
    Nilima Prakash
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Exp Cell Res 278:31-44. 2002
    ..These data show that Notch 3 expression is conserved between mouse and human and suggest that the mouse is a valid system for analysis of CADASIL...
  19. ncbi Characterization of Notch receptor expression in the developing mammalian heart and liver
    Kathleen M Loomes
    Division of Gastroenterology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med Genet 112:181-9. 2002
    ..In the newborn mouse liver, Notch2 and Notch3 are expressed in opposing cell populations, suggesting they play different roles in cell fate determination during ..
  20. ncbi Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 37:139-43. 2003
    ..To analyze the in vivo role of the Notch3 gene in mice, we created a deletion allele by gene targeting...
  21. ncbi gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 7:731-43. 2004
    ....
  22. pmc Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
    Valérie Domenga
    INSERM E365, Faculté de Médecine Lariboisiere, Paris 75010, France
    Genes Dev 18:2730-5. 2004
    Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle ..
  23. ncbi Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice
    Takeo Kitamoto
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 331:1154-62. 2005
    The Notch3 gene, a member of the Notch gene family, is expressed in a wide variety of tissues during development. We generated and analyzed Notch3-deficient mice to assess the in vivo role of the Notch3 gene...
  24. ncbi Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 286:472-82. 2005
    ..Thus, Notch signaling plays a non-autonomous role in digit septation...
  25. ncbi Notch3 signaling promotes radial glial/progenitor character in the mammalian telencephalon
    Louis Dang
    Institute for Cell Engineering, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Neurosci 28:58-69. 2006
    ..In light of studies suggesting that Notch3 can antagonize Notch1, we tested the effects of activated Notch3 (NICD3) in the mouse telencephalon...
  26. pmc Canonical notch signaling functions as a commitment switch in the epidermal lineage
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 20:3022-35. 2006
    ....
  27. pmc Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing
    Diana Bellavia
    Department of Experimental Medicine, University La Sapienza, Roma, Italy
    EMBO J 26:1670-80. 2007
    Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell ..
  28. ncbi NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    Shuting Bai
    Departments of Pathology and Immunology, Molecular Biology and Pharmacology, and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:6509-18. 2008
    ..Although NOTCH1 and NOTCH3 collaborate in regulating osteoclast formation, NOTCH1 is the dominant paralog...
  29. pmc Linking Notch signaling to ischemic stroke
    Joseph F Arboleda-Velasquez
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:4856-61. 2008
    ....
  30. doi Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells
    Shaobo Jin
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Circ Res 102:1483-91. 2008
    Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunction...
  31. pmc Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity
    Shadmehr Demehri
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e123. 2008
    ..These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations...
  32. doi A deficiency of lunatic fringe is associated with cystic dilation of the rete testis
    K L Hahn
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Reproduction 137:79-93. 2009
    ..Further, the dye studies demonstrated that many lunatic fringe mutant males had partial blocks of the connection between the rete testis and the efferent ducts bilaterally...
  33. pmc Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries
    E J Belin de Chantemèle
    INSERM U 771, Angers, France
    Arterioscler Thromb Vasc Biol 28:2216-24. 2008
    b>Notch3, a member of the evolutionary conserved Notch receptor family, is primarily expressed in vascular smooth muscle cells...
  34. pmc Smooth muscle Notch1 mediates neointimal formation after vascular injury
    Yuxin Li
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 119:2686-92. 2009
    ..However, the pathophysiological role of Notch1 in the postnatal period is not known. We hypothesize that Notch1 signaling in vascular smooth muscle cells (SMCs) may contribute to neointimal formation after vascular injury...
  35. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
    ..A similar defect was observed in Notch2(beta-geo/+)Notch3(beta-geo/beta-geo) compound mutant mice but not in Notch2(beta-geo/+) or Notch3(beta-geo/beta-geo) single mutants...
  36. pmc Notch3 is critical for proper angiogenesis and mural cell investment
    Hua Liu
    National Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
    Circ Res 107:860-70. 2010
    ..Yet, the molecular mechanisms underlying their association have not been fully defined...
  37. doi Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle regeneration
    Takeo Kitamoto
    Department of Bioscience, Kitasato University School of Science, Sagamihara, Kanagawa, Japan
    Stem Cells 28:2205-16. 2010
    ..role in muscle regeneration through promoting proliferation and self-renewal of satellite cells, the function of Notch3 is yet to be elucidated. We analyzed muscle regeneration in Notch3-deficient mutant mice...
  38. pmc Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
    Xuesong Feng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:4191-9. 2010
    ..This new model for a common congenital heart defect provides novel insights into the genetic programs that underlie ductus arteriosus development and closure...
  39. doi Notch3 is essential for regulation of the renal vascular tone
    Nada Boulos
    INSERM UMR702, Paris, France
    Hypertension 57:1176-82. 2011
    The Notch3 receptor participates in the development and maturation of vessels. Mutations of Notch3 in humans are associated with defective regulation of cerebral blood flow...
  40. pmc ΔNp63α promotes cellular quiescence via induction and activation of Notch3
    Sierra Kent
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH, USA
    Cell Cycle 10:3111-8. 2011
    ..Additionally, ΔNp63α and other quiescence-inducing stimuli enhanced expression of Notch3 in HC11s and breast cancer cell lines, and ectopic expression of the Notch3 intracellular domain (N3 (ICD) ) was ..
  41. pmc Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice
    Silvia Fre
    Morphogenesis and Intracellular Signaling, Institut Curie UMR144 CNRS, Paris, France
    PLoS ONE 6:e25785. 2011
    ..This roster of knock-in and reporter mice represents a valuable resource to functionally explore the Notch pathway in vivo in virtually all tissues...
  42. pmc Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate
    T A Mitsiadis
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Cell Biol 130:407-18. 1995
    ..These data suggest that Notch genes may be involved in mediating some of the biological effects of retinoic acid during normal development and after teratogenic exposure...
  43. ncbi Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development
    M P Felli
    Department of Experimental Medicine, University of L Aquila, Aquila 67100, Italy
    Int Immunol 11:1017-25. 1999
    ..Moreover, a differential distribution of Notch3, with respect to Notch1, was observed in distinct age-related thymocyte subsets...
  44. ncbi Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
    Tuija Mustonen
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Dev Biol 248:281-93. 2002
    ..We conclude that Lunatic fringe may play a role in boundary formation of the enamel knot and that Notch-signaling in the dental epithelium is regulated by mesenchymal FGFs and BMP...
  45. ncbi Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
    Ryosuke Tsunematsu
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Biol Chem 279:9417-23. 2004
    ..Expression of Notch1, -2, or -3 or of cyclin E was unaffected in Fbw7(-/-) embryos. Mammalian Fbw7 thus appears to play an indispensable role in negative regulation of the Notch4-Hey1 pathway and is required for vascular development...
  46. pmc RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
    Yufeng Dong
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 137:1461-71. 2010
    ..Finally, Hes1 was identified as an RBPjkappa-dependent Notch target gene important for MPC maintenance and the suppression of in vitro chondrogenesis...
  47. pmc Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease
    Yi Zhang
    Bone Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 117:299-308. 2011
    ..These results identify Notch as a novel essential regulator of pathogenic CD4(+) T-cell responses during acute GVHD and suggest that Notch signaling in T cells should be investigated as a therapeutic target after allogeneic HSCT...
  48. pmc Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells
    Akinobu Matsumoto
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    J Biol Chem 286:13754-64. 2011
    ..The maintenance of neural stem cells was sustained in association with the accumulation of Notch1 and Notch3, as well as up-regulation of Notch target genes in the mutant mice...
  49. doi Extracellular YB-1 blockade in experimental nephritis upregulates Notch-3 receptor expression and signaling
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Nephron Exp Nephrol 118:e100-8. 2011
    ....
  50. pmc Notch controls the magnitude of T helper cell responses by promoting cellular longevity
    Christina Helbig
    Department of Cell Biology and Histology, Academic Medical Center, 1105AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:9041-6. 2012
    ..Our findings, therefore, show that Notch controls the magnitude of CD4(+) T-cell responses by promoting cellular longevity...
  51. pmc Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
    Vuk P Jovanovic
    Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
    Reprod Biol Endocrinol 11:43. 2013
    ..We hypothesized that blocking Notch pathways would disrupt follicular maturation in the mouse ovary...
  52. doi Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism
    Emmanuel Cognat
    From the INSERM, U740 and Univ Paris Diderot, Sorbonne Cité, UMR S740, Paris, France E C, C B M, V D D, S C, C F, M M L, A J and Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB KU Leuven, Leuven, Belgium M D
    Stroke 45:842-9. 2014
    ..the most common heritable small vessel disease of the brain, is caused by dominant mutations in the NOTCH3 receptor that stereotypically lead to age-dependent Notch3ECD deposition in the vessels...
  53. pmc Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling
    Chieko Ishifune
    Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 111:5986-91. 2014
    ..These data indicate that Notch signaling is essential for lineage fixation of intestinal CD11c(+)CX3CR1(+) cells. ..
  54. doi Activity-dependent Notch signalling in the hypothalamic-neurohypophysial system of adult mouse brains
    T Mannari
    Department of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan
    J Neuroendocrinol 26:497-509. 2014
    ..In the present study, we examined the expression of Notch3 and Delta-like ligand 4 (DLL4) in the hypothalamic-neurohypophysial system (HNS) of the adult mouse...
  55. pmc Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors
    Munemasa Mori
    Columbia Center for Human Development, Department of Medicine, Pulmonary Allergy Critical Care, Columbia University Medical Center, New York, NY 10032, USA
    Development 142:258-67. 2015
    ..Here, we show by genetic and pharmacological approaches that endogenous activation of Notch3 signaling selectively controls the pool of undifferentiated progenitors of upper airways available for ..
  56. pmc Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells
    Jeremy T Baeten
    From the Center for Cardiovascular and Pulmonary Research, and The Heart Center at Nationwide Children s Hospital, and the Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205
    J Biol Chem 290:16226-37. 2015
    ..In this study, we identify unique roles for NOTCH2 and NOTCH3 in regulating proliferation and cell survival in cultured VSMCs...
  57. pmc Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice
    Carmen Capone
    Genetics and Pathogenesis of Cerebrovascular Diseases, INSERM, U1161 and Univ Paris Diderot, Sorbonne Paris Cité, UMRS 1161, F 75010, Paris, France
    Ann Neurol 79:387-403. 2016
    CADASIL is a genetic paradigm of cerebral small vessel disease caused by NOTCH3 mutations that stereotypically lead to the extracellular deposition of NOTCH3 ectodomain (Notch3(ECD) ) on the vessels...
  58. ncbi Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
    T A Mitsiadis
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Development 124:1473-83. 1997
    ..This indicates that, at least during tooth development, the expression patterns observed for receptors and ligands in the Notch signaling pathway are generated by different induction mechanisms...
  59. pmc Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    Xiaofeng Zheng
    Departments of Cell and Molecular Biology and Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3368-73. 2008
    ..In conclusion, the data reveal posttranslational modification of the activated form of the Notch receptor and an intricate mode of cross-coupling between the Notch and hypoxia signaling pathways...
  60. pmc Mutation discovery in mice by whole exome sequencing
    Heather Fairfield
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Genome Biol 12:R86. 2011
    ..We found strong candidate mutations for the majority of mutant exomes sequenced, including new models of orofacial clefting, urogenital dysmorphology, kyphosis and autoimmune hepatitis...
  61. doi Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Goedele Wallays
    Vesalius Research Center, Flanders Institute for Biotechnology VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 31:2881-8. 2011
    ..and leukoencephalopathy (CADASIL) is an adult-onset neurovascular disorder caused by stereotyped mutations in the NOTCH3 receptor...
  62. pmc Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients
    Ryan Humphreys
    Department of Surgery, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 21:1374-83. 2012
    ..Future studies will investigate the mechanism in which Jagged1 acts in a cell autonomous and cell non-autonomous manner...
  63. pmc Notch2 and Notch3 function together to regulate vascular smooth muscle development
    Qingqing Wang
    Center for Cardiovascular and Pulmonary Research, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 7:e37365. 2012
    ..Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only mild defects in ..
  64. doi Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury
    Sonja Djudjaj
    Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Pathol 228:286-99. 2012
    ..Thus, specific blockade of this receptor may be suitable as therapeutic option to delay progression of kidney disease...
  65. pmc Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts
    Jeffrey Gagan
    Department of Biochemistry and Molecular Genetics, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Biol Chem 287:40360-70. 2012
    b>Notch3 is expressed in myogenic precursors, but its function is not well known.
  66. ncbi Functional conservation of mouse Notch receptor family members
    H Kato
    Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Sakyo ku, Japan
    FEBS Lett 395:221-4. 1996
    ..These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP-Jkappa...
  67. ncbi Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
    ..1 (a region of conserved synteny to mouse Chromosome 5). In addition, we also found multiple SRPK-related sequences on other human chromosomes, one of which appears to correspond to a SRPK2 pseudogene on human chromosome 8...
  68. ncbi Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
    K Shimizu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655 Japan
    J Biol Chem 274:32961-9. 1999
    ..Finally, solid-phase binding assay showed that Jagged1 binds to Notch1 and Notch3 in addition to Notch2, suggesting that mJagged1 is a ligand for multiple Notch receptors.
  69. ncbi Notch gene expression during pancreatic organogenesis
    E Lammert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mech Dev 94:199-203. 2000
    ..Notch 3 and Notch 4 are expressed in pancreatic mesenchyme and later in endothelial cells. Together these descriptive data comprise a framework for understanding the cellular basis for Notch function during pancreatic development...
  70. ncbi Notch/Delta expression in the developing mouse lung
    L C Post
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mech Dev 98:95-8. 2000
    ..Here, we report the localization of transcripts of several genes encoding members of the Notch/Delta pathway in the early mouse lung. Most genes are expressed in specific populations and so may contribute to cell diversification...
  71. pmc Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
    T Mizutani
    Department of Medical Chemistry and Department of Neurosurgery, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 98:9026-31. 2001
    ..These results demonstrate the conserved biochemical mechanism of signal transduction among mammalian Notch family members...
  72. ncbi Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
    M T Saxena
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Biol Chem 276:40268-73. 2001
    ..Despite a high degree of structural homology and the presenilin-dependent activity of truncated Notch proteins, the extent that this reflects functional redundancy is unknown...
  73. ncbi Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression
    T A Mitsiadis
    Faculté d Odontologie, Universite de la Mediterranee, 13385 cedex 05, Marseille, France
    Mech Dev 109:399-403. 2001
    ..e. neuronal tissues) or to cell proliferation events (i.e. eye, vascular structures, hematopoiesis)...
  74. ncbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    Q Yang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 294:2155-8. 2001
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  75. pmc Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4
    Denis Houzelstein
    Laboratory of Mammalian Development, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Mol Cell Biol 22:3794-802. 2002
    ..Natl. Acad. Sci. USA 95:8538-8543, 1998) and the Brd4 mutant phenotype is discussed in light of this result. Together, our results provide the first genetic evidence for an in vivo role in mammals for a member of the Fsh/Brd family...
  76. ncbi Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
    Cornelia Leimeister
    Theodor Boveri Institute, Biozentrum, Physiological Chemistry I, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany
    Gene Expr Patterns 3:595-8. 2003
    ..Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules...
  77. ncbi Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
    Emanuela Anastasi
    Department of Clinical Sciences, University La Sapienza, Rome, Italy
    J Immunol 171:4504-11. 2003
    ..In this study, we demonstrate that Notch3 expression is a characteristic feature of CD4(+)CD25(+) cells...
  78. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..Thus, biliary epithelium has the potential for pancreatic differentiation and Hes1 determines biliary organogenesis by preventing the pancreatic differentiation program, probably by directly repressing transcription of Neurog3...
  79. pmc Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
    Michael T Tetzlaff
    Department of Human and Molecular Genetics, Texas Children s Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:3338-45. 2004
    ..These data suggest essential functions for Fbw7 in controlling cyclin E and Notch signaling pathways in the mouse...
  80. ncbi Expression of Apc2 during mouse development
    Hiroki Yamanaka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Brain Res Gene Expr Patterns 1:107-14. 2002
    ..During development of cortex, retina and cerebellum, Apc2 is expressed in post-mitotic cells. These findings suggest that Apc2 may contribute to the development of neuronal cells...
  81. ncbi Functional diversity of notch family genes in fetal lung development
    Yanping Kong
    Brigham and Women s Hospital, Dept of Pathology, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1075-83. 2004
    ..Cumulatively, these observations suggest that interactions between distinct Notch family members can have diverse tissue-specific regulatory functions during development, arguing against simple functional redundancy...
  82. ncbi Notch expression in developing olfactory neuroepithelium
    Kiyoshi Doi
    Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kusunoki cho 7 5 1, Chuo Ku, Kobe 650 0017, Japan
    Neuroreport 15:945-7. 2004
    ..During the developmental stage, Notch1 was mainly observed around the basal membrane, while Notch3 was observed in the lower compartment of the olfactory neuroepithelium...
  83. ncbi Developmental expression of the Notch signaling pathway genes during mouse preimplantation development
    Sarah Cormier
    Unite de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Gene Expr Patterns 4:713-7. 2004
    ..Notch4 and Dll-4 mRNAs are synthesized from the 2-cell through to the hatched blastocyst stage. Notch3, Dll-1 and Dtx1exhibit a stage dependent expression as their mRNAs are detected in 2-cell embryos and in hatched ..
  84. ncbi Notch3 signaling initiates choroid plexus tumor formation
    L Dang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 25:487-91. 2006
    b>Notch3 has been studied in the context of brain development, but whether it plays a role in the formation of brain tumors is unclear...
  85. ncbi Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud
    Jeffrey C Francis
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK
    Dev Dyn 234:1006-15. 2005
    ..Regulation of the extent of the AER is achieved by Notch signalling positively regulating apoptosis in the AER. We also demonstrate that Notch1 is not required for proper formation of all the derivatives of the limb mesenchyme...
  86. ncbi Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis
    Claudio Talora
    Dipartimento di Medicina Sperimentale e Patologia, University La Sapienza, Viale Regina Elena 32400161 Roma, Italy
    Blood 107:3313-20. 2006
    ..However, specific target genes and molecular partners are not fully elucidated. We show that Notch3 activation sustains aberrant SCL/Tal1 overexpression and phosphorylation in mature thymocytes...
  87. pmc Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia
    Alessandra Vacca
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, Italy
    EMBO J 25:1000-8. 2006
    ..is required for thymocytes proliferation and leukemogenesis, it is dispensable for thymocyte differentiation in Notch3-transgenic mice...
  88. pmc The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression
    Junling Jia
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:7236-47. 2007
    ..We found that the Notch effector Herp2 is expressed in lens epithelium and directly suppresses p57Kip2 expression, providing a molecular link between Notch signaling and the cell cycle control machinery during lens development...
  89. pmc Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium
    Steve Rodriguez
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 314:40-58. 2008
    ..Surprisingly, expression of Notch3 is also down-regulated...
  90. pmc Notch signaling maintains Leydig progenitor cells in the mouse testis
    Hao Tang
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3745-53. 2008
    ....
  91. pmc Notch signaling in bulge stem cells is not required for selection of hair follicle fate
    Shadmehr Demehri
    Department of Developmental Biology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 136:891-6. 2009
    ..Taken together, our findings yield detailed insight into the function of Notch signaling in hair follicle stem cells and reveal the mechanism of the replacement of Notch-deficient adult hair follicles by epidermal cysts...
  92. pmc Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression
    Hong Soon Kang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 29:6366-79. 2009
    ..In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function...
  93. pmc Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart
    Konrad Urbanek
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:429-41. 2010
    ..Physiological hypertrophy in the developing heart has been considered the product of an increase in volume of preexisting fetal cardiomyocytes in the absence of myocyte formation...
  94. pmc Targeted genome modification in mice using zinc-finger nucleases
    Iara D Carbery
    Sigma Advanced Genetic Engineering Labs, Sigma Aldrich Biotechnology, St Louis, MO 63146, USA
    Genetics 186:451-9. 2010
    ..Three individual genes, multidrug resistant 1a (Mdr1a), jagged 1 (Jag1), and notch homolog 3 (Notch3), were targeted in FVB/N and C57BL/6 mice...
  95. pmc Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
    Robin Jeannet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Blood 116:5443-54. 2010
    ..Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how these receptors contribute to T-cell transformation in ..
  96. pmc Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)- and Th17-type expansion involving Notch3 and Delta-like1
    Z Jiao
    Central Laboratory, Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University Pathogenic Biology Immunology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang Department of Laboratory Medicine, Jiangyin People s Hospital, Jiangyin, China
    Clin Exp Immunol 164:66-71. 2011
    ..The mRNA level of Notch3 was also up-regulated significantly, while the levels of the other three Notch receptors were not increased...
  97. doi Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription
    Alessandro Barbarulo
    Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy
    J Immunol 186:6199-206. 2011
    b>Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression of Foxp3, in cooperation with the pTα/pre-TCR pathway...
  98. pmc Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery
    Shamik Ghosh
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:22678-87. 2011
    b>Notch3 signaling is fundamental for arterial specification of systemic vascular smooth muscle cells (VSMCs). However, the developmental role and signaling properties of the Notch3 receptor in the mouse pulmonary artery remain unknown...
  99. doi Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon
    Shengxi Wu
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556 Japan
    Development 138:2499-509. 2011
    ..IPGNs are maintained in the neocortex and may act as progenitors for adult neurogenesis...
  100. pmc A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    Apostolos Klinakis
    Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Nature 473:230-3. 2011
    ..Our studies identify a novel role for Notch signalling during early haematopoietic stem cell differentiation and suggest that the Notch pathway can play both tumour-promoting and -suppressive roles within the same tissue...
  101. ncbi Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway
    H Nakayama
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Genet 21:21-30. 1997
    ..These data suggest that Notch signaling through activation of HES transcriptional repressors may play a role in murine placental development...

Research Grants2

  1. MOLECULAR CLONING OF A T(15;19) IN LUNG CANCER CELL LINE
    Thao Dang; Fiscal Year: 2005
    ..we demonstrated that the breakpoint on chromosome 19 lies approximately 40 kb upstream from the start site of Notch3, a member of the Notch proto- oncogene family...
  2. Notch3 signaling in small-artery-diseases
    Anne Joutel; Fiscal Year: 2009
    ..We will investigate effect of the archetypal R90C CADASIL mutation on NotchS wildtype activity in vivo using our Notch3R90C mice, NotchS null mice as a "rescue" system and transgenic RBP-JK reporter mice (Aim # 3). ..