Nos2

Summary

Gene Symbol: Nos2
Description: nitric oxide synthase 2, inducible
Alias: MAC-NOS, NOS-II, Nos-2, Nos2a, i-NOS, iNOS, nitric oxide synthase, inducible, NOS type II, inducible NO synthase, inducible NOS, inducible nitric oxide synthase, macrophage NOS, nitric oxide synthase 2, inducible, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Species: mouse

Top Publications

  1. ncbi Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene
    J E Fenyk-Melody
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Immunol 160:2940-6. 1998
  2. ncbi Nitric oxide synthases: roles, tolls, and controls
    C Nathan
    Beatrice and Samuel Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, New York 10021
    Cell 78:915-8. 1994
  3. ncbi IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2
    M van Den Broek
    Institute for Experimental Immunology, Zurich, Switzerland
    J Immunol 164:371-8. 2000
  4. ncbi Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    Bo Huang
    Departments of Gene and Cell Medicine and General Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Res 66:1123-31. 2006
  5. ncbi NOS2 regulation of NF-kappaB by S-nitrosylation of p65
    Zachary T Kelleher
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:30667-72. 2007
  6. pmc Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages
    L Moreno
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 160:1997-2007. 2010
  7. pmc Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression
    Muhannad Shweash
    Division of Physiology and Pharmacology, Strathclyde Institute for Pharmacy and Biomedical Sciences, 27 Taylor Street, Glasgow G4 0NR, UK
    Mol Immunol 48:1800-8. 2011
  8. ncbi Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice
    H Mashimo
    Department of Veteran Affairs Medical Center, West Roxbury 02132, Massachusetts, USA
    Am J Physiol 277:G745-50. 1999
  9. pmc Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 194:1207-18. 2001
  10. ncbi Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Synapse 34:305-12. 1999

Detail Information

Publications181 found, 100 shown here

  1. ncbi Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene
    J E Fenyk-Melody
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Immunol 160:2940-6. 1998
    ..to be a prominent mediator of inflammation based in part on the correlative expression of the inducible nitric oxide synthase (iNOS) gene in various pathologies...
  2. ncbi Nitric oxide synthases: roles, tolls, and controls
    C Nathan
    Beatrice and Samuel Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, New York 10021
    Cell 78:915-8. 1994
  3. ncbi IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2
    M van Den Broek
    Institute for Experimental Immunology, Zurich, Switzerland
    J Immunol 164:371-8. 2000
    ..Thus, our results identify a new role for IL-12 in defense beyond the induction of IFN-gamma and show that IL-4 and IL-10 modulate host protective responses to VV...
  4. ncbi Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    Bo Huang
    Departments of Gene and Cell Medicine and General Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Res 66:1123-31. 2006
    ..Our data provide evidence that Gr-1(+)CD115(+) MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses...
  5. ncbi NOS2 regulation of NF-kappaB by S-nitrosylation of p65
    Zachary T Kelleher
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:30667-72. 2007
    Signal transduction in the NF-kappaB transcription factor pathway is inhibited by inducible nitric oxide synthase (NOS2) activity, although the molecular mechanism(s) are incompletely understood...
  6. pmc Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages
    L Moreno
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 160:1997-2007. 2010
    ..Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products activate NOD1. Activation of NOD1 by the specific agonist FK565 results in a profound vascular dysfunction and experimental shock in vivo...
  7. pmc Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression
    Muhannad Shweash
    Division of Physiology and Pharmacology, Strathclyde Institute for Pharmacy and Biomedical Sciences, 27 Taylor Street, Glasgow G4 0NR, UK
    Mol Immunol 48:1800-8. 2011
    ..MAP kinase signalling in mouse bone marrow macrophages and subsequent expression of the disease regulatory proteins iNOS and COX-2 were studied...
  8. ncbi Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice
    H Mashimo
    Department of Veteran Affairs Medical Center, West Roxbury 02132, Massachusetts, USA
    Am J Physiol 277:G745-50. 1999
    ..depends on its enzymatic sources, namely neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS), each having distinct tissue localization...
  9. pmc Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 194:1207-18. 2001
    ..We have investigated the role of three key RONS-metabolizing enzymes (inducible nitric oxide synthase [iNOS], superoxide dismutase [SOD], nicotinamide adenine dinucleotide phosphate [NADPH] oxidase) in a ..
  10. ncbi Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Synapse 34:305-12. 1999
    ..in the dopaminergic neurotoxicity, the present study was undertaken to investigate whether the inducible nitric oxide synthase (iNOS) isoform is also associated with METH- and MPTP-induced neurotoxicity...
  11. pmc Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro
    A Vazquez-Torres
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Exp Med 192:227-36. 2000
    The contribution of the NADPH phagocyte oxidase (phox) and inducible nitric oxide (NO) synthase (iNOS) to the antimicrobial activity of macrophages for Salmonella typhimurium was studied by using peritoneal phagocytes from C57BL/6, ..
  12. ncbi Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
    L Zheng
    Department of Medicine, 448B Biomedical Research Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Diabetologia 50:1987-96. 2007
    ..of the production of several components of the inflammatory response in the retina, including inducible nitric oxide synthase (iNOS)...
  13. pmc The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis
    Sindhu Saraswathy
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 51:3680-6. 2010
    ..Methods. TLR4(-/-), iNOS(-/-), TNF-alpha(-/-), MyD88(-/-), wild-type (WT) control (C57BL/6), and nude mice (B6...
  14. pmc Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice
    Yu Jin Jung
    The Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 196:991-8. 2002
    ..cytokines, to upregulate the antimycobacterial function of macrophages of which the synthesis of inducible nitric oxide synthase (NOS)2 is an essential event...
  15. ncbi Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Mol Immunol 45:2106-15. 2008
    ..LPS (1 microg/mL) maximally induced inducible nitric oxide synthase (iNOS) and HO-1 mRNAs in wild-type (WT) macrophages at 6h and 12h after treatment, respectively, and ..
  16. pmc Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy
    S Armando Villalta
    Molecular, Cellular and Integrative Physiology Program, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 1606, USA
    Hum Mol Genet 18:482-96. 2009
    ..Genetic ablation of the iNOS gene in mdx mice also significantly reduces muscle membrane lysis in 4-week-old mdx mice in vivo...
  17. pmc Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment
    Mahtab Moayeri
    Laboratory of Bacterial Diseases, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001222. 2010
    ..These data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1β in countering anthrax infection...
  18. ncbi Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
    C R Lyons
    Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, Massachusetts
    J Biol Chem 267:6370-4. 1992
    ..from L-arginine and molecular oxygen. We report the cloning of a cDNA encoding the inducible nitric oxide synthase from a murine macrophage cell line, RAW264.7, exposed to interferon-gamma and lipopolysaccharide...
  19. ncbi Altered immune responses in mice lacking inducible nitric oxide synthase
    X Q Wei
    Department of Immunology, University of Glasgow, UK
    Nature 375:408-11. 1995
    ..It is generated from L-arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated by several immunological stimuli, leading to the production of large quantities of NO ..
  20. ncbi Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis
    U C Sahrbacher
    Departement of Internal Medicine, University Hospital Zurich, Switzerland
    Eur J Immunol 28:1332-8. 1998
    Nitric oxide (NO) generated by the inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE)...
  21. pmc Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA
    J Exp Med 202:1163-9. 2005
    Brains from subjects who have Alzheimer's disease (AD) express inducible nitric oxide synthase (iNOS). We tested the hypothesis that iNOS contributes to AD pathogenesis...
  22. pmc Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide
    Edward Chiang
    Division of Biological Sciences and University of California San Diego Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 176:5720-4. 2006
    ..ASK1 kinase activity proved essential for IRF3-mediated ISG induction by LPS. Thus, our results presented here suggest a novel role for ROS and ASK1 in the innate immune response as signaling intermediates in the IRF3 activation pathway...
  23. ncbi MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge
    Leif D Nelin
    Center for Perinatal Research, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Physiol Cell Physiol 293:C632-40. 2007
    L-Arginine (L-arg) is metabolized to nitric oxide (NO) by inducible NO synthase (iNOS) or to urea and L-ornithine (L-orn) by arginase...
  24. ncbi Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362
    K Xie
    Department of Cell Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 55:3123-31. 1995
    The purpose of this study was to determine whether the activation of inducible nitric oxide synthase (iNOS) can serve as a target for immunotherapeutic agents for treatment of murine reticulum cell sarcoma metastases...
  25. ncbi Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondii
    I A Khan
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 161:2994-3000. 1998
    ..gondii is unknown. Mice with a targeted disruption of inducible NO synthase (iNOS) were immunized with an avirulent temperature-sensitive strain of this parasite (ts-4)...
  26. ncbi Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase
    Guntram Thoeni
    Biocenter, Division of Biological Chemistry, Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria
    J Immunol 174:7584-91. 2005
    ..Experiments with cells from inducible NOS (iNOS) knockout mice and with N(6)-(1-iminoethyl)-L-lysine, a specific inhibitor of iNOS, ruled out ..
  27. ncbi Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4
    Bo Holmqvist
    Department of Pathology, Inst Medical Sciences, Lund University, Lund, Sweden
    J Mol Histol 36:499-516. 2005
    ..nitric oxide (NO)-producing NO synthase (NOS) isoforms, endothelial NOS (eNOS) and neuronal NOS (nNOS) and inducible NOS (iNOS) in kidneys from wild-type mice (WT) and immune deficient Toll-like receptor 4 (TLR4) mutant mice, ..
  28. pmc Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury
    Marion Hölscher
    Department of Cardiovascular Physiology, Universitatsmedizin Gottingen, Georg August University Gottingen, Gottingen, Germany
    J Biol Chem 286:11185-94. 2011
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction...
  29. pmc Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases
    Kazuya Kuboyama
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, University of Kyushu, Fukuoka, Japan
    Mol Pain 7:50. 2011
    ..pain using mice lacking a single NO synthase (NOS) gene among the three isoforms: neuronal (nNOS), inducible (iNOS) and endothelial (eNOS)...
  30. pmc Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera
    Eun Jung Park
    College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA
    Nutr Cancer 63:971-82. 2011
    ..4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate (RBITC), which was found to suppress inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264...
  31. pmc Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation
    Mariam Malik
    Laboratory of Cancer Biology and Genetics and Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:6130-5. 2012
    ..Here we demonstrate that CLIC4 is induced concurrently with inducible nitric oxide synthase (iNOS) and S-nitrosylated in proinflammatory peritoneal macrophages...
  32. doi Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway
    Seo Yoon Chang
    Department of Physiology, College of Medicine, The Catholic University, 505 Banpo Dong, Socho gu, Seoul 137 701, Korea
    J Cell Biochem 114:844-53. 2013
    ..the mechanism by which exendin-4 (EX-4), a potent GLP-1 receptor agonist, inhibits lipopolysaccharide (LPS)-induced iNOS expression in Raw264.7 macrophage cells...
  33. ncbi Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis
    Jinkyung Ko
    Laboratory of Cellular and Molecular Immunology, Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 168:2433-40. 2002
    ....
  34. ncbi Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences
    Nicholas J Kenyon
    Pulmonary and Critical Care Medicine, School of Medicine, University of California, Davis, CA 95616 8723, USA
    Toxicol Appl Pharmacol 191:2-11. 2003
    ..aerosol of a different strain of mice, C57BL/6, and compared this response to an otherwise isogenic C57BL strain (iNOS(-/-)) in which the gene for inducible nitric oxide synthetase (iNOS) had been knocked out...
  35. pmc Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism
    F L A C Mestriner
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 104:19595-600. 2007
    ..The inhibitory activity was blocked by 50 mg/kg aminoguanidine, s.c., and was not demonstrable in inducible nitric oxide synthase (iNOS) knockout mice...
  36. doi Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin
    Thomas J Calvert
    The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Am J Physiol Heart Circ Physiol 294:H1621-9. 2008
    ..to low-dose LPS with a fall in blood pressure due to augmented expression of inducible nitric oxide (NO) synthase (iNOS)...
  37. pmc IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1
    Malabendu Jana
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Glia 57:1553-65. 2009
    Earlier we have demonstrated that IL-12 p40 homodimer (p40(2)) induces the expression of inducible nitric oxide synthase (iNOS) in microglia...
  38. doi Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β
    Eun Jin Chang
    College of Pharmacy, Seoul National University, Seoul, South Korea
    Mol Carcinog 50:310-7. 2011
    ..NF-κB), which is known to regulate expression of various pro-inflammatory genes including inducible nitric oxide synthase (iNOS)...
  39. ncbi Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
    M U Shiloh
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York 10021, USA
    Immunity 10:29-38. 1999
    ..of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2)...
  40. ncbi Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase
    S R Kleeberger
    Department of Environmental Health Sciences, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 280:L326-33. 2001
    We tested the hypotheses that 1) inducible nitric oxide synthase (iNOS) mediates ozone (O3)-induced lung hyperpermeability and 2) mRNA levels of the gene for iNOS (Nos2) are modulated by Toll-like receptor 4 (Tlr4) during O3 exposure...
  41. ncbi Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with alpha-actinin 4
    Sharon Daniliuc
    Immunology Research Unit and Ischemia Shock Research Laboratory, Carmel Medical Center, Rappaport Family Institute for Research in the Medical Sciences, and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Immunol 171:3225-32. 2003
    Nitric oxide, produced in macrophages by the high output isoform inducible NO synthase (iNOS), is associated with cytotoxic effects and modulation of Th1 inflammatory/immune responses...
  42. ncbi A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice
    Masaki Fujimoto
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 6604, Charlestown, MA 02129, USA
    Diabetes 54:1340-8. 2005
    ..b>Inducible nitric oxide synthase (iNOS) has been implicated in many human diseases associated with inflammation...
  43. ncbi Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice
    Marco A Carvalho-Filho
    Departamento de Clinica Medica, Universidade Estadual de Campinas, UNICAMP, 13081 970, Campinas SP, Brazil
    Am J Physiol Endocrinol Metab 291:E476-82. 2006
    We have previously demonstrated that the insulin resistance associated with inducible nitric oxide synthase (iNOS) induction in two different models of obesity, diet-induced obesity and the ob/ob mice, is mediated by S-nitrosation of ..
  44. pmc The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally admi
    J B Weinberg
    Department of Medicine, Veterans Administration Medical Center, Durham, North Carolina 27705
    J Exp Med 179:651-60. 1994
    ..nitric oxide synthase activity, and certain tissues from MRL-lpr/lpr mice had increased expression of inducible nitric oxide synthase (NOS) mRNA and increased amounts of material immunoreactive for inducible NOS...
  45. ncbi Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase
    S M Hollenberg
    Sections of Critical Care and Cardiology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Circ Res 86:774-8. 2000
    ..To evaluate the significance of cytokine-inducible nitric oxide synthase (iNOS) in the pathogenesis of sepsis, we used a clinically relevant mouse model of sepsis and ..
  46. ncbi Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice
    S D Chauhan
    Clinical Pharmacology, Barts and The London, Queen Mary s School of Medicine, London EC1M 6BQ, UK
    FASEB J 17:773-5. 2003
    ..inflammation-induced endothelial dysfunction may be related to the expression and activity of inducible nitric oxide synthase (iNOS)...
  47. ncbi Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity
    Brian T Noronha
    Cardiovascular Division, King s College London, UK
    Diabetes 54:1082-9. 2005
    Previous studies have suggested an involvement of inducible nitric oxide synthase (iNOS) in obesity, but the relation, if any, between this and mechanisms underlying endothelial dysfunction in obesity is unknown...
  48. ncbi Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    Sangwon F Kim
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 310:1966-70. 2005
    Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity...
  49. pmc NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease
    C A Colton
    Division of Neurology, and Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:12867-72. 2006
    ....
  50. pmc Lymphocyte development requires S-nitrosoglutathione reductase
    Zhiyong Yang
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 185:6664-9. 2010
    ..in S-nitrosylation and apoptosis in GSNOR-deficient mice are largely abolished by genetic deletion of inducible NO synthase. Furthermore, the protection of lymphocyte development by GSNOR is apparently intrinsic to hematopoietic ..
  51. ncbi Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
    Q W Xie
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021
    Science 256:225-8. 1992
    ..The macrophage enzyme is immunologically induced at the transcriptional level and closely resembles the enzyme in cytokine-treated tumor cells and inflammatory neutrophils...
  52. pmc Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-alpha and IL-1-beta
    F Q Cunha
    Wellcome Research Laboratories, Beckenham, Kent, U K
    Immunology 81:211-5. 1994
    ..In addition, NO synthase activity is differentially expressed in various organs and this may not always require TNF-alpha and IL-1 beta...
  53. ncbi Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection
    T M Doherty
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 158:4822-31. 1997
    ..In contrast, knockout mice lacking the genes for the TNF-alpha p55/p75 receptors or inducible nitric oxide synthase not only developed comparable bacterial loads to wild-type animals, they also failed to display the ..
  54. ncbi Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomy
    C Teuscher
    Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign 61802, USA
    J Immunol 163:2262-6. 1999
    ..Similarly, cDNA sequence polymorphisms in Nos2, Scya3, Scya4, Scya5, Scya6, Scya7, Scya9, Scya10, and Scya11 were excluded as candidates for eae7...
  55. ncbi Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice
    T Zhao
    Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Circulation 102:902-7. 2000
    ..We determined the role of inducible nitric oxide synthase (iNOS) in mediating adenosine-induced late cardioprotection using pharmacological inhibitors and iNOS ..
  56. pmc Ubiquitination of inducible nitric oxide synthase is required for its degradation
    Pawel J Kolodziejski
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:12315-20. 2002
    b>Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators. We have previously shown that iNOS is degraded through the 26S proteasome...
  57. ncbi Cardiovascular and renal control in NOS-deficient mouse models
    Pablo A Ortiz
    Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Regul Integr Comp Physiol 284:R628-38. 2003
    ..Endogenous NO is produced by three different NO synthase (NOS) isoforms: endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS)...
  58. ncbi Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes
    Gary Wright
    Laboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:20235-9. 2003
    ..These results point to a key role for the PHD pathway in the phenotypic changes that are observed in a hypoxic myocyte and may suggest a strategy to pharmacologically induce protection in heart...
  59. ncbi Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase
    Lesley G Ellies
    Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Int J Cancer 106:1-7. 2003
    ..have used the polyomavirus middle T antigen (PyV-mT) targeted to the mouse mammary gland and bred into an inducible NO synthase (iNOS)-deficient C57Bl/6 strain to examine a role for nitric oxide in modulating tumors that develop in ..
  60. ncbi Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase
    F Tao
    Department of Anesthesiology and Critical Care Medicine, Blalock 1415, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 4965, USA
    Neuroscience 120:847-54. 2003
    To date, the exact role of inducible nitric oxide synthase (iNOS) in inflammatory pain remains controversial...
  61. ncbi Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and p
    Kristen M Clements
    Imperial College London, London, UK
    Arthritis Rheum 48:3452-63. 2003
    ..the medial collateral ligament and partial medial meniscectomy in mice in which genes encoding either interleukin-1beta (IL-1beta), IL-1beta-converting enzyme (ICE), stromelysin 1, or inducible nitric oxide synthase (iNOS) were deleted.
  62. ncbi TGFbeta inhibits IL-1 -induced iNOS expression and NO production in immortalized chondrocytes
    K Vuolteenaho
    The Immunopharmacological Research Group Medical School, University of Tampere and Research Unit, Tampere University Hospital, 33014 Tampere, Finland
    Inflamm Res 54:420-7. 2005
    ..IL-1 and TNFalpha enhance nitric oxide (NO) production in OA cartilage through the inducible nitric oxide synthase (iNOS) pathway and NO mediates many of the destructive effects of these cytokines...
  63. ncbi The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages
    Daniela De Stefano
    Dipartimento di Farmacologia Sperimentale, via D Montesano 49, University of Naples Federico II, 80131 Naples, Italy
    J Mol Med (Berl) 84:65-74. 2006
    ..signal transducer and activator of transcription-1alpha (STAT-1alpha) on the synergistic induction of inducible nitric oxide synthase (iNOS) gene expression by gliadin (G) in association with interferon-gamma (IFN-gamma) in RAW 264...
  64. ncbi Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts
    Carlos Zaragoza
    Fundación Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    J Cell Sci 119:1896-902. 2006
    ..we detected increased matrix metalloproteinase (MMP)-13 mRNA, protein and activity, as well as increased inducible NO synthase (iNOS) and NO production during the differentiation of MC3T3-E1 osteoblasts...
  65. ncbi Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
    ..injection of complete Freund's adjuvant (CFA) in wild-type (WT) mice and in mice lacking either inducible (iNOS), endothelial (eNOS) or neuronal NOS (nNOS)...
  66. ncbi Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
    Hiroyuki Tezuka
    Department of Immunology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Nature 448:929-33. 2007
    ..Here we show that IgA class-switch recombination (CSR) is impaired in inducible-nitric-oxide-synthase-deficient (iNOS-/-; gene also called Nos2) mice...
  67. doi Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible nitric oxide synthase in endothelial cells
    Tongzheng Liu
    Division of Pharmacology, The Ohio State University College of Pharmacy, 500 West Twelfth Ave, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 295:C819-27. 2008
    ..the level or activity of several transcription factors that can induce the inducible nitric oxide (NO) synthase (iNOS). PIN1 can also regulate mRNA and protein turnover...
  68. doi Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia
    A S Naura
    Louisiana State University Health Sciences Center, Dept of Pharmacology and Experimental Therapeutics, 1901 Perdido St, New Orleans, LA 70112, USA
    Eur Respir J 33:252-62. 2009
    b>Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease...
  69. pmc Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme
    C J Lowenstein
    Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 89:6711-5. 1992
    ..A neuronal form of NO synthase (NOS) has been previously cloned. We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity to the neuronal enzyme...
  70. ncbi Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages
    F Y Liew
    Wellcome Research Laboratories, Beckenham, GB
    Eur J Immunol 21:3009-14. 1991
    ..S, C57BL and C3H mice produced significantly higher levels of NO than the macrophages from the susceptible BALB.b and DBA/2 mice...
  71. pmc Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death
    V E Laubach
    Division of Experimental Therapy, Burroughs Wellcome Co, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 92:10688-92. 1995
    Nitric oxide produced by cytokine-inducible nitric oxide synthase (iNOS) is thought to be important in the pathogenesis of septic shock...
  72. ncbi Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    J D MacMicking
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, New York 10021, USA
    Cell 81:641-50. 1995
    Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that iNOS defends the host against infectious agents and tumor cells at the risk of contributing to tissue damage and shock...
  73. ncbi Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide
    R B Lorsbach
    Wilkinson Laboratory, Cancer Center, University of Kansas Medical Center, Kansas City 66160 7184
    J Biol Chem 268:1908-13. 1993
    ....
  74. pmc Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
    Q W Xie
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York 10021
    J Exp Med 177:1779-84. 1993
    b>Inducible nitric oxide synthase (iNOS) can be expressed by many types of mammalian cells in response to diverse signals acting synergistically, including cytokines and microbial products...
  75. ncbi Molecular cloning and expression of an avian macrophage nitric-oxide synthase cDNA and the analysis of the genomic 5'-flanking region
    A W Lin
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:11911-9. 1996
    ..This is in contrast to the two distinct sites identified in the mouse macrophage NOS promoter. Transcription factor binding sites such as NF-kappaB, PEA1, PEA3, and C/EBP were identified...
  76. pmc Elevated blood pressures in mice lacking endothelial nitric oxide synthase
    E G Shesely
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill 27599, USA
    Proc Natl Acad Sci U S A 93:13176-81. 1996
    ..Comparisons between the current eNOS mutant mice and previously generated inducible nitric oxide synthase mutants showed that homozygous mutants for the latter differ in having unaltered blood pressures and ..
  77. pmc Identification of nitric oxide synthase as a protective locus against tuberculosis
    J D MacMicking
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:5243-8. 1997
    ..Several such pathways may function as activators of a common protective gene: inducible nitric oxide synthase (NOS2)...
  78. pmc Nitric oxide synthases: which, where, how, and why?
    T Michel
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 100:2146-52. 1997
  79. pmc Cellular and molecular mechanisms of endothelial cell dysfunction
    D G Harrison
    Emory University, Department of Internal Medicine and the Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 100:2153-7. 1997
  80. pmc Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer
    K Yamasaki
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 101:967-71. 1998
    Most evidence indicates that nitric oxide plays a role in normal wound repair; however, involvement of inducible nitric oxide synthase (iNOS) has not been established...
  81. ncbi Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production
    F P Huang
    Department of Immunology, University of Glasgow, Western Infirmary, United Kingdom
    J Immunol 160:4143-7. 1998
    ..Thus, Fas expression is essential for resistance against leishmaniasis, and Fas-mediated apoptosis may form an integral part of the Th1-mediated microbicidal function...
  82. ncbi IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis
    C J Hertz
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin, 53706, USA
    Cell Immunol 192:24-32. 1999
    ..of inducible NO production in infection, we monitored survival, parasitemia, and Th cell cytokine production in iNOS KO mice...
  83. ncbi Requirement for type 2 NO synthase for IL-12 signaling in innate immunity
    A Diefenbach
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
    Science 284:951-5. 1999
    Interleukin-12 (IL-12) and type 2 NO synthase (NOS2) are crucial for defense against bacterial and parasitic pathogens, but their relationship in innate immunity is unknown...
  84. ncbi Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice
    D J Lefer
    Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport, Louisiana 71130, USA
    Am J Physiol 276:H1943-50. 1999
    ..25 U/ml) superfusion in the mesentery of wild-type, inducible NOS (iNOS)-deficient (-/-), neuronal NOS (nNOS) -/-, and endothelial cell NOS (ecNOS) -/- mice to further our ..
  85. ncbi Effects of nitric oxide on the induction and differentiation of Th1 cells
    W Niedbala
    Department of Immunology, University of Glasgow, Glasgow, GB
    Eur J Immunol 29:2498-505. 1999
    We have previously shown that mice lacking inducible NO synthase are markedly more susceptible to Leishmania major infection but developed a significantly enhanced Th1 cell response compared with wild-type mice...
  86. ncbi Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
    G T Liberatore
    Department of Neurology, Columbia University, New York, New York 10032, USA
    Nat Med 5:1403-9. 1999
    ..a robust gliosis in the substantia nigra pars compacta associated with significant upregulation of inducible nitric oxide synthase (iNOS). These changes preceded or paralleled MPTP-induced dopaminergic neurodegeneration...
  87. ncbi The role of nitric oxide in innate immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Immunol Rev 173:17-26. 2000
    Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L-arginine, and thereby contributes to the control of ..
  88. pmc Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Exp Med 192:237-48. 2000
    The roles of the NADPH phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS) in host resistance to virulent Salmonella typhimurium were investigated in gp91phox(-/)-, iNOS(-/)-, and congenic wild-type mice...
  89. pmc Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice
    L B Adams
    National Hansen s Disease Programs, Laboratory Research Branch at Louisiana State University, Baton Rouge, Louisiana 70894, USA
    Infect Immun 68:5462-5. 2000
    ..This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.
  90. ncbi Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice
    P A Detmers
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Immunol 165:3430-5. 2000
    b>Inducible NO synthase (iNOS) present in human atherosclerotic plaques could contribute to the inflammatory process of plaque development...
  91. ncbi Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice
    K Yogo
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 20:E96-E100. 2000
    ..of the left common carotid artery was performed in control, endothelial NOS (eNOS) knockout (eNOS-KO), and inducible NOS (iNOS) knockout (iNOS-KO) mice...
  92. ncbi Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury
    H Kobayashi
    Department of Medicine, Kitasato University School of Medicine, Kanagawa, Japan
    Am J Respir Cell Mol Biol 24:390-7. 2001
    The objective of this study was to determine whether endogenous nitric oxide (NO), specifically the inducible NO synthase isoform (iNOS: NOS II), reduces or amplifies lung injury in mice breathing at a high oxygen tension...
  93. ncbi Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity
    S L Michael
    Department of Pharmacology and Toxicology, College of Medicine, Little Rock, Arkansas 72205, USA
    Nitric Oxide 5:432-41. 2001
    ..This manuscript examines APAP (300 mg/kg) hepatotoxicity in mice lacking inducible nitric oxide synthase activity (NOS2 null or knockout mice; C57BL/6-Nos2(tm1Lau)) and in the wildtype mice...
  94. ncbi Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    M Perreault
    Department of Anatomy and Physiology, Lipid Research Unit and Research Center on Energy Metabolism, Laval University Hospital Research Center, Ste Foy, Quebec, Canada
    Nat Med 7:1138-43. 2001
    b>Inducible nitric oxide synthase (iNOS) is induced by inflammatory cytokines in skeletal muscle and fat. It has been proposed that chronic iNOS induction may cause muscle insulin resistance...
  95. ncbi Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse
    D J Scott
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds, England, UK
    Gastroenterology 121:889-99. 2001
    The role of the inducible isoform of nitric oxide synthase (Nos2 or iNOS) in intestinal tumorigenesis is unclear...
  96. pmc The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice
    C A Scanga
    Departments of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Infect Immun 69:7711-7. 2001
    ..function via the production of nitric oxide by the inducible isoform of the enzyme nitric oxide synthase (NOS2)...
  97. ncbi Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism
    M Hesse
    Schistosomiasis Immunology and Pathology Unit and Max Planck Institut für Immunbiologie, Freiburg, Germany
    J Immunol 167:6533-44. 2001
    ....
  98. ncbi Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyte
    Yang Wang
    Experimental Research Laboratory, Division of Cardiology, Louisville, KY 40292, USA
    J Mol Cell Cardiol 34:5-15. 2002
    ..afforded by the late phase of ischemic preconditioning (PC) is mediated by upregulation of inducible nitric oxide synthase (iNOS)...
  99. ncbi Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury
    Martina Dörger
    Institute for Surgical Research, University of Munich, Munich, Germany
    Free Radic Biol Med 33:491-501. 2002
    ..By comparing the responses of inducible nitric oxide synthase (iNOS) knockout and wild-type mice we investigated the consequences of iNOS expression for the ..
  100. ncbi Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes
    Lichao Chen
    Department of VCAPP, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 973:214-22. 2003
    ..In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period...
  101. ncbi Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice
    Matthew J DiMagno
    Department of Internal Medicine, The University of Michigan Medical School, 1500 E Medical Center Dr, 3912 Taubman Center, Ann Arbor, MI 48109 0362, USA
    Am J Physiol Gastrointest Liver Physiol 286:G428-36. 2004
    ..NOS inhibitors lack specificity and three NOS isoforms exist: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS)...

Research Grants40

  1. Nitric Oxide Defense Against Porphyromonas gingivalis
    Robert Gyurko; Fiscal Year: 2006
    ..periodontal bone loss in normal mice and in mutant mice which do not produce NO in response to bacteria (iNOS KO mice). We found that iNOS KO mice are resistant to P. gingivalis induced bone loss...
  2. In vivo study of diabetic hyperglycemia and inflammation
    Robert Gyurko; Fiscal Year: 2009
    ..Moreover, findings on novel lipid inhibitors of inflammation will be important in evaluating the therapeutic potential of these compounds in resolving inflammation in periodontal and other inflammations. ..
  3. Regulation of neuronal NO by apolipoprotein E
    Carol Colton; Fiscal Year: 2006
    ....
  4. Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2008
    ..One of several mechanisms by which NF-kappaB may initiate tumor formation is through induction of the inducible nitric oxide synthase (iNOS) leading to production of NO, a molecule important in the suppression of T cell immunity and ..
  5. Immune Responsiveness, APOE/Gender in Neurodegeneration
    Carol Colton; Fiscal Year: 2008
    ..Thus, we will examine the role of hormones in the regulation of microglial and peritoneal macrophage immune activation in mice expressing only human apoE3 protein or expressing only human apoE4 protein. ..
  6. Regulation of Microglial Activation
    Carol Colton; Fiscal Year: 2003
    ..Our preliminary data demonstrate that regulating the level of substrate for iNOS by altering the cellular uptake of arginine via CAT transporters is one such point...
  7. Role of SV40 in Salivary Gland Tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2003
    ..Analysis of molecular changes occurring during salivary gland tumorigenesis may lead to the development of therapeutic agents for the treatment of malignant disease. ..
  8. ADHESION MOLECULES IN NO MODULATED TUMORIGENESIS
    LESLEY ELLIES; Fiscal Year: 2004
    ..the MMTV/PyV middle T antigen gene which have been crossed with mice deficient in the inducible nitric oxide gene, NOS2 or the L-arginine transporter, CAT2 will be utilized in these studies...
  9. Experimental Uveal Melanoma and Ocular Immune Privilege
    KYLE MCKENNA; Fiscal Year: 2007
    ..abstract_text> ..
  10. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006
    ....
  11. GENE KNOCK-OUT MICE AS MODELS FOR THE LEPROSY SPECTRUM
    Linda Adams; Fiscal Year: 2006
    ..leprae in targeted gene KO mice an ideal model for analyzing the principal redundant and compensatory mechanisms of CMI in host resistance to infection in general and to intracellular mycobacterial pathogens in particular. ..
  12. Effects of BMPRII Mutations in Pulmonary Hypertension
    Karen Fagan; Fiscal Year: 2006
    ..We will have also tested the role of four pulmonary cell types, smooth muscle, endothelium, airway epithelium and macrophages in the link between BMPR2 and pulmonary hypertension. ..
  13. 2006 Grover Conference on the Pulmonary Circulation - Rho Family GTPases
    Karen Fagan; Fiscal Year: 2006
    ..The ranch is an intimate setting that encourages interaction between scientists and clinicians. We are requesting funding to support travel and lodging for invited speakers. [unreadable] [unreadable] [unreadable] [unreadable]..
  14. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 2007
    ..abstract_text> ..
  15. Study of Intrinsic Bladder Activity by Optical Imaging
    Anthony Kanai; Fiscal Year: 2007
    ..To study the neural-chemical control of spontaneous detrusor activity; and III.) To determine the origin of detrusor overactivity in partially obstructed bladders. ..
  16. Genetics of Pulmonary Hypertension in Mice
    Karen Fagan; Fiscal Year: 2006
    ..abstract_text> ..
  17. Proteomics of Oxidant-Induced Mitochondrial Damage in an Animal Model of NASH
    Shannon Bailey; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  18. NOS2 and arginase in visceral leishmaniasis
    Peter Melby; Fiscal Year: 2009
    ..in the hamster model of VL, a Type 1 T cell response is mounted, but is ineffective and accompanied by undetectable NOS2 expression...
  19. Salt Absorption by the THAL: Role of NKCC2 trafficking
    Pablo A Ortiz; Fiscal Year: 2010
    ..Data from this proposal will increase our understanding of how salt absorption by the THAL is regulated in normal and salt-sensitive animals, and will identify new targets for the development of diuretics. ..
  20. Cellular Immunity to Chlamydua at the Epithelial Interface
    RAYMOND MORRIS JOHNSON; Fiscal Year: 2010
    ..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..
  21. Testing therapeutic pathways in genetic glaucoma
    RICHARD LIBBY; Fiscal Year: 2004
    ..These experiments will provide insight into pathways responsible for pressure induced RGC degeneration. Additionally these experiments will provide insight into the location of neuronal insults in glaucoma. ..
  22. EXTRACELLULAR SUPEROXIDE DISMUTASE AND ATHEROSCLEROSIS
    David Harrison; Fiscal Year: 2001
    ....
  23. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..Improved understanding of these endogenous vasoregulatory substances, their interactions with one another, and the effect of modest hypoxia in vivo are the major goals of this proposal and may lead to new therapeutic options. ..
  24. Chronic Alcohol and Liver Oxidative Stress
    Shannon Bailey; Fiscal Year: 2003
    ..This investigation should thus provide information on ethanol-elicited alterations that contribute to oxidative damage in the liver. ..
  25. MOLECULAR TOOLS TO DEVELOP HAMSTER MODELS OF DISEASE
    Peter Melby; Fiscal Year: 2003
    ..This work will have particular relevance to research traditionally funded through a number of NIH institutes including the NCI, NIAID, NHLBI, NIA, NIAMS, and NIDR. ..
  26. VACCINATION OF DOGS TO REDUCE TRANSMISSION OF LEISHMANIA
    Peter Melby; Fiscal Year: 2003
    ..Successful vaccination of dogs in an endemic could reduce both enzootic (among the canine reservoir) and zoonotic (from the canine reservoir to humans) transmission. ..
  27. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
    ..The results will be important for immunodeficient humans chronically infected with the parasite. ..
  28. LETHAL OROESOPHAGEAL CANDIDIASIS: IMMUNOTHERAPY
    Edward Balish; Fiscal Year: 2004
    ..Restoration and enhancement of immune function may be critical for the effectiveness of anti-Candida vaccines that are now under development. ..
  29. MOLECULAR CONTROL OF CELL MIGRATION IN THE SPINAL CORD
    JOSEPH YIP; Fiscal Year: 2004
    ..Results will provide important insights on the molecular and cellular basis of Reelin function, and may reveal significant information about the mechanisms responsible for devastating diseases caused by abnormal migration. ..
  30. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  31. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  32. Immunobiology of Chlamydia
    Raymond Johnson; Fiscal Year: 2004
    ..3) To determine the effect of adoptive transfer of mucosal CD8 and CD4 T lymphocytes on the natural course of MoPn genital tract infections. ..
  33. Redox Modification of Thiols in Alcohol Hepatotoxicity
    Shannon Bailey; Fiscal Year: 2008
    ..New information on the molecular targets of SAM will also be achieved, which will enable the design of effective therapeutic strategies to treat liver diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  34. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  35. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  36. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  37. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  38. CYTOKINE DYSFUNCTION AND LUNG 5LO METABOLISM IN AIDS
    Michael Coffey; Fiscal Year: 2002
    ..This proposal will further enhance our ability to correct this defect and help boost AM, PBM, and PMN defenses against opportunistic infections in the lung in HIV disease. ..
  39. Nitric Oxide Regulation of Compensatory Lung Growth
    VICTOR LAUBACH; Fiscal Year: 2005
    ..To test this hypothesis, knockout mice deficient in endothelial NO synthase (eNOS), inducible NOS (iNOS), and both eNOS/iNOS will be used to study NO-mediated mechanisms of post-pneumonectomy CLG...