Genomes and Genes
Nogo 66 receptor
Gene Symbol: Nogo 66 receptor
Description: reticulon 4 receptor
Alias: NOGOR, NgR, NgR1, reticulon-4 receptor, Nogo-66 receptor, nogo receptor, nogo receptor; Nogo-66 receptor, nogo66 receptor-1
- Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migrationChiara Rolando
Department of Neuroscience, University of Turin, I 10126 Turin, Italy
J Neurosci 32:17788-99. 2012..In the mouse brain, we found that the plasticity inhibitors Nogo-A and Nogo receptor 1 (NgR1) are differentially expressed in the SVZ-OB system, in which Nogo-A identifies immature neuroblasts ..
- Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavageGino B Ferraro
Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
J Biol Chem 286:31418-24. 2011Nogo-66 receptor 1 (NgR1) is a glycosylphosphatidylinositol-anchored receptor for myelin-associated inhibitors that restricts plasticity and axonal regrowth in the CNS...
- Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibitionKarthik Venkatesh
Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Cell Biol 177:393-9. 2007Neuronal Nogo66 receptor-1 (NgR1) binds the myelin inhibitors NogoA, OMgp, and myelin-associated glycoprotein (MAG) and has been proposed to function as the ligand-binding component of a receptor complex that also includes Lingo-1, p75(..
- Nogo receptor 1 regulates formation of lasting memoriesAlexandra Karlén
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:20476-81. 2009..We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for ..
- Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticityStephen J Raiker
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:12432-45. 2010..Nogo and OMgp complex with the neuronal cell surface receptors Nogo receptor-1 (NgR1) and paired Ig-like receptor-B (PirB) to regulate neuronal morphology...
- Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptorLei Zhang
Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Neurosci 29:6348-52. 2009..We hypothesize that BLyS may be a negative regulator for neuronal functions. Here Nogo-66 receptor (NgR) is identified as a high affinity receptor for BLyS, which inhibits dorsal root ganglion outgrowth in culture...
- Nogo receptor is involved in the adhesion of dendritic cells to myelinClaire L McDonald
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
J Neuroinflammation 8:113. 2011Nogo-66 receptor NgR1 and its structural homologue NgR2 are binding proteins for a number of myelin-associated inhibitory factors...
- Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5Verena Wörter
Innsbruck Medical University, Biocenter, Division of Neurobiochemistry, Innsbruck, Austria
PLoS ONE 4:e5218. 2009..Two members of the Nogo-receptor (NgR) family, NgR1 and NgR2, have been identified as neuronal binding proteins of MAG...
- Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitisKarin Steinbach
Institute for Neuroimmunology and Clinical MS Research, Hamburg, Germany
PLoS ONE 6:e26341. 2011..b>NgR1 and NgR2 were identified as interaction partners for the myelin proteins Nogo-A, MAG and OMgp and are probably ..
- Recovery from chronic spinal cord contusion after Nogo receptor interventionXingxing Wang
Cellular Neuroscience, Neurodegeneration, and Repair Program, and Department of Neurology, Yale School of Medicine, New Haven, CT 06536 0812, USA
Ann Neurol 70:805-21. 2011..shortly after central nervous system injury, including blockade of myelin-derived inhibitors with soluble Nogo receptor (NgR1, RTN4R) decoy protein...
- The nogo receptor family restricts synapse number in the developing hippocampusZachary P Wills
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 73:466-81. 2012..Here we demonstrate that glycosylphosphatidylinositol-anchored cell-surface receptors of the Nogo Receptor family (NgR1, NgR2, and NgR3) restrict excitatory synapse formation...
- Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 micePaschalis Theotokis
B Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, Thessaloniki, Macedonia, Greece
J Neuropathol Exp Neurol 71:907-20. 2012..The results indicate that Nogo-A and Nogo receptor are actively regulated in EAE lesions; this may indicate a specific time window for localized axonal ..
- Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strengthHakjoo Lee
Department of Biomedical Genetics, Center for Neural Development and Disease, Interdepartmental Graduate Program for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 28:2753-65. 2008..Members of the Nogo-66 receptor family have been implicated in regulating neuronal morphology. Nogo-66 receptor 1 (NgR1) supports binding of the myelin inhibitors Nogo-A, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte ..
- Anatomical plasticity of adult brain is titrated by Nogo Receptor 1Feras V Akbik
Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT 06536, USA
Neuron 77:859-66. 2013..examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1)...
- A role for Nogo receptor in macrophage clearance from injured peripheral nerveElizabeth J Fry
Center for Research in Neuroscience, The McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada
Neuron 53:649-62. 2007..Increasing numbers of macrophages in crushed rat sciatic nerves express NgR1 and NgR2 on the cell surface in the first week after injury...
- The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growthWilliam B J Cafferty
Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 26:12242-50. 2006The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies...
- Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivoBinhai Zheng
Department of Biological Sciences, Program in Neurosciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 102:1205-10. 2005..Neuronal Nogo receptor (NgR) binds to each of the three inhibitors and has been proposed to mediate their inhibitory signals by ..
- Identification of a receptor mediating Nogo-66 inhibition of axonal regenerationA E Fournier
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 409:341-6. 2001..Nogo-66 receptor expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and its receptor provides the potential for enhanced recovery after human CNS injury...
- Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptorBetty P Liu
Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Science 297:1190-3. 2002..The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor ..
- Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteinsWilliam A Barton
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
EMBO J 22:3291-302. 2003..that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR)...
- Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systemsJuha Lauren
Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Helsinki, Finland
Mol Cell Neurosci 24:581-94. 2003..Currently only the Nogo receptor (NgR), in complex with p75(NTR) neurotrophin receptor is known to be involved in this inhibitory signalling in ..
- Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesionsAna Mingorance
Development and Regeneration of the CNS, Barcelona Science Park IRBB, University of Barcelona, E 08028 Barcelona, Spain
Mol Cell Neurosci 26:34-49. 2004..Here we study the onset and maturation of Nogo-A and Nogo receptor in the entorhino-hippocampal formation of developing and adult mice...
- Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injuryJi Eun Kim
Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
Neuron 44:439-51. 2004..All three of these proteins bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro...
- Experience-driven plasticity of visual cortex limited by myelin and Nogo receptorAaron W McGee
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 309:2222-6. 2005..We find that mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity...
- Plasticity of binocularity and visual acuity are differentially limited by nogo receptorCéleste Élise Stephany
Developmental Neuroscience Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California 90027
J Neurosci 34:11631-40. 2014..the plasticity of binocularity and acuity are separable and differentially regulated by the neuronal nogo receptor 1 (NgR1)...
- Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonistsGareth Williams
Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
J Biol Chem 283:16641-52. 2008..In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is mediated by the sialic acid moiety ..
- Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contactXingxing Wang
Departments of Neurology and Neurosurgery and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 22:5505-15. 2002..An interaction of Nogo on the oligodendrocyte surface with Nogo-66 Receptor (NgR) on axons has been suggested to play an important role in limiting axonal growth...
- Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injuryChad S Siegel
Department of Neurology and
J Neurosci 35:1443-57. 2015..the pathways driving spontaneous functional recovery in wild-type and plasticity-sensitized mice lacking Nogo receptor 1...
- Nogo Receptor 1 Limits Ocular Dominance Plasticity but not Turnover of Axonal Boutons in a Model of AmblyopiaMichael G Frantz
Developmental Neuroscience Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
Cereb Cortex 26:1975-85. 2016..alter the dynamics of intracortical axonal boutons in visual cortex of either adult wild-type (WT) mice or adult NgR1 mutant (ngr1-/-) mice that retain critical period visual plasticity...
- LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligandYuji Kurihara
Molecular Medical Bioscience Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, Suehiro cho 1 7 29, Tsurumi ward, Yokohama 230 0045, Japan
Mol Cell Neurosci 61:211-8. 2014..MAG), oligodendrocyte myelin glycoprotein (OMgp), and B lymphocyte stimulator (BLyS) commonly bind to Nogo receptor-1 (NgR1), leading to enormous restriction of functional recovery after damage to the adult central nervous ..
- Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growthNaoki Nakaya
Section of Molecular Mechanisms of Glaucoma, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 0606, USA
J Biol Chem 287:37171-84. 2012..this study, we identified Olfm1 as a molecule promoting axon growth through interaction with the Nogo A receptor (NgR1) complex...
- NogoR1 and PirB signaling stimulates neural stem cell survival and proliferationSrinivas Ramasamy
Institute of Medical Biology, 8A Biomedical Grove, 05 37 Immunos, Singapore
Stem Cells 32:1636-48. 2014..In NSCs, NogoR1 functions through Rho whereas PirB uses Shp1/2 signaling pathways to control NSC behavior. Taken together, this work suggests that Nogo signaling is an important pathway for survival of NSCs...
- Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injuryJing Tong
Department of Neurosurgery and Center for Translational Neuromedicine, University of Rochester, Rochester, New York Department of Neurosurgery, Fourth Affiliated Hospital of Hebei Medical University, Hebei, China Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, China and Department of Neurosurgery, Baylor Scott and White Health, Temple, Texas
Neurosurgery 75:51-60. 2014Neuronal Nogo-66 receptor 1 (NgR1) has attracted attention as a converging point for mediating the effects of myelin-associate inhibitory ligands in the central nervous system, establishing the growth-restrictive environment, and limiting ..
- Myocilin is involved in NgR1/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerveHeung Sun Kwon
Retinal Ganglion Cell Biology Section, Laboratory of Retinal Cell and Molecular Biology and Histology Core, National Eye Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, and Neuro Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892
J Neurosci 34:5539-51. 2014..Myocilin stimulation of oligodendrocyte differentiation occurs through the NgR1/Lingo-1 receptor complex. Myocilin physically interacts with Lingo-1 and may be considered as a Lingo-1 ligand...
- The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory ActivationYinquan Fang
From the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tongjiaxiang Street, Nanjing 210009, China
J Biol Chem 290:28901-14. 2015..Our previous study has confirmed that Nogo receptor (NgR), an axon outgrowth inhibition receptor, is also expressed on microglia and regulates cell adhesion and ..
- Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- MiceKathren L Fink
Department of Neurology and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520
J Neurosci 35:15403-18. 2015..Using crym-GFP, we reevaluated the CST in mice lacking nogo receptor 1 (NgR1), a protein implicated in limiting neural repair...
- Agenesis of the corpus callosum in Nogo receptor deficient miceSeung Wan Yoo
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205
J Comp Neurol 525:291-301. 2017..Imbalance of these cues results in CC agenesis or dysgenesis. Nogo receptors (NgR1, NgR2, and NgR3) are growth cone directive molecules known for inhibiting axon regeneration after injury...
- Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approachesRuby Hsu
Department of Neuroscience, Columbia University, New York, New York, United States of America
PLoS ONE 2:e1234. 2007b>NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.
- Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathwaysXingxing Wang
Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT, USA
Exp Neurol 237:55-69. 2012..of either astrocyte-derived chondroitin sulfate proteoglycans (CSPGs) or oligodendrocyte-derived NogoReceptor (NgR1) ligands reduces extrinsic inhibition of axonal growth, though combined blockade of these distinct pathways has not ..
- NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycansTravis L Dickendesher
Neuroscience Program, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Nat Neurosci 15:703-12. 2012..The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition...
- Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in miceJing Tong
Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurotrauma 30:247-58. 2013..glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1)...
- The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1Yuji Kurihara
Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Fuku ura 3 9, Kanazawa Ward, Yokohama 236 0004, Japan
Biochem Biophys Res Commun 418:390-5. 2012Myelin-derived axon growth inhibitors, such as Nogo, bind to Nogo receptor-1 (NgR1) and thereby limit the action of axonal regeneration after injury in the adult central nervous system...
- NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performanceMarcel M van Gaalen
Neuroscience Research, GPRD, Abbott, 67061 Ludwigshafen, Germany
Neurosci Lett 510:58-61. 2012The Nogo-66 receptor (NgR1) is part of a co-receptor complex on neurons that transmits a signal for inhibition of neurite outgrowth...
- Critical period for acoustic preference in miceEun Jin Yang
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 109:17213-20. 2012..Instead, exposing adult mice treated acutely with valproic acid or carrying a targeted deletion of the Nogo receptor (NgR(-/-)) unmasked a strong plasticity of preference consistent with a reopening of the critical period as ..
- Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophreniaLaurie R Earls
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Neurosci 32:14132-44. 2012..We conclude that miRNA-dependent SERCA2 dysregulation is a pathogenic event in 22q11DS and schizophrenia...
- Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse modelsM Kvajo
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Neuroscience 211:136-64. 2012..Finally, we discuss emerging mouse models, such as second-generation pathophysiology models based on innovative approaches that are facilitated by the information gathered from the current genetic mouse models...
- Nogo receptor antagonizes p75NTR-dependent motor neuron deathLuc Dupuis
Institut National de la Sante et de la Recherche Medicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F 67085 France
Proc Natl Acad Sci U S A 105:740-5. 2008The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system...
- Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formationVincent Pernet
Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
J Neurosci 28:7435-44. 2008..The common binding protein for Nogo-A and MAG, NgR1, was exclusively upregulated in MAG(-/-) animals, whereas the level of Lingo-1, a coreceptor, remained unchanged...
- Localization of Nogo and its receptor in the optic pathway of mouse embryosJun Wang
Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong Special Administrative Region, China
J Neurosci Res 86:1721-33. 2008..In vitro studies showed that the Nogo receptor (NgR) was expressed on the neurites and growth cones from both the ventral temporal and dorsal nasal quadrant ..
- Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regenerationCherry Ee Lin Ng
NCA Lab, Institute of Molecular and Cell Biology, Singapore, Republic of Singapore
J Neurosci Res 67:559-65. 2002..The 66-amino acid extracellular domain of Nogo (Nogo-66) interacts with a high-affinity receptor (NgR), a glycosylphosphatidylinositol (GPI)-linked protein with multiple leucine-rich repeats...
- Toward simpler and faster genome-wide mutagenesis in miceSen Wu
Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
Nat Genet 39:922-30. 2007....
- Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque depositionJames H Park
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 26:1386-95. 2006..A Nogo to Nogo-66 receptor (NgR) pathway contributes to determining the ability of adult CNS axons to extend after traumatic injuries...
- Regeneration of lesioned entorhino-hippocampal axons in vitro by combined degradation of inhibitory proteoglycans and blockade of Nogo-66/NgR signalingAna Mingorance
Development and Regeneration of the CNS, Department of Cell Biology, IRB PCB, University of Barcelona, Barcelona, Spain
FASEB J 20:491-3. 2006..For example, NEP1-40 is a synthetic peptide that promotes axonal regeneration by blocking Nogo-66/NgR interaction and chondroitinase ABC (ChABC), which degrades CS, thereby also promoting axon regrowth...
- Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents?Felicia Yu Hsuan Teng
Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, Singapore
J Neurochem 94:865-74. 2005IN-1, the monoclonal antibody against the exon 3-encoded N-terminal domain of Nogo-A, and the Nogo-66 receptor (NgR) antagonist NEP1-40 have both shown efficacy in promoting regeneration in animal spinal cord injury models, the latter ..
- Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injuryShuxin Li
Department of Neurology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06510, USA
Mol Cell Neurosci 29:26-39. 2005..after spinal injury is thought to be limited in part by myelin-derived proteins that act via the Nogo-66 Receptor (NgR)...
- Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injuryShuxin Li
Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 23:4219-27. 2003..oligodendrocyte-myelin glycoprotein, and myelin-associated glycoprotein, all bind to an axonal Nogo-66 receptor (NgR) and at least partially account for this lack of CNS repair...
- Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humansAnna Josephson
Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Comp Neurol 453:292-304. 2002....
- Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosisYvonne S Yang
Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
J Neurosci 29:13850-9. 2009..Our results provide a novel intracellular role for reticulon proteins and support the hypothesis that modulation of PDI function is a potential therapeutic approach to ALS...
- Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genesT M Maynard
Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
Mol Cell Neurosci 39:439-51. 2008..Our results suggest that altered dosage of one, or several 22q11 mitochondrial genes, particularly during early post-natal cortical development, may disrupt neuronal metabolism or synaptic signaling...
- Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growthStephane Budel
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06536, USA
J Neurosci 28:13161-72. 2008..Neuronal cultures demonstrate that four different schizophrenia-derived NgR1 variants fail to transduce myelin signals into axon inhibition, and function as dominant negatives to disrupt ..
- Axonal protective effects of the myelin-associated glycoproteinThien Nguyen
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neurosci 29:630-7. 2009..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss...
- Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model miceKazunori Miyazaki
Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Neurol Res 31:316-21. 2009Detailed assessment of Nogo-A and its receptor NgR in the spinal cord of amyotrophic lateral sclerosis (ALS) models or patients has not been reported previously, and we examined the expression and distribution patterns of Nogo-A and NgR ..
- Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cellsYuan Gao
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People s Republic of China
Stem Cells Dev 19:53-60. 2010..However, its expression regulation largely remains unknown. In this study we show that Nogo receptor (NgR) participates in the regulation of Nanog expression via Stat3 pathway...
- Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formationYasufumi Sato
Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
Science 333:769-73. 2011..We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein...
- Axonal regeneration of optic nerve after crush in Nogo66 receptor knockout miceYing Su
Department of Ophthalmology, First Clinical College of Harbin Medical University, Harbin 150001, China
Neurosci Lett 460:223-6. 2009..myelin-associated glycoprotein (MAG) and Omgp, exert their effects on neuron regeneration through the Nogo receptor (NgR)...
- Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in miceNoah L Lazar
Department of Psychology, University of Western Ontario, London, ON, Canada
Behav Brain Res 224:73-9. 2011..Given the mild effect of the R189H mutation of Rtn4r on behavioural phenotypes relevant to schizophrenia, our results do not support missense mutation of RTN4R as a strong risk factor in the pathogenesis of schizophrenia...
- A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1Eric A Huebner
Department of Neurology and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06536, USA
J Biol Chem 286:18026-36. 2011..Three regions of Nogo-A (Nogo-A-24, Nogo-66, and Nogo-C39) interact with the neuronal Nogo-66 receptor 1 (NgR1)...
- An age-related sprouting transcriptome provides molecular control of axonal sprouting after strokeSonglin Li
Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
Nat Neurosci 13:1496-504. 2010..This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery...
- Localization of an axon growth inhibitory molecule Nogo and its receptor in the spinal cord of mouse embryosJun Wang
Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University, Beijing, China
Brain Res 1306:8-17. 2010The localization of an axon growth inhibitory molecule Nogo and its receptor (NgR) was investigated in the mouse spinal cord during prenatal development of the commissural pathway...
- Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injuryNoam Y Harel
Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
J Neurotrauma 27:2055-66. 2010..Genetically, we reduced myelin-mediated inhibition of neural plasticity through Nogo66-receptor (NgR) gene deletion. Behaviorally, we utilized a novel multimodal exercise training paradigm...
- Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous systemMarija M Petrinovic
Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Development 137:2539-50. 2010..The same effects are seen with antibodies against the Nogo receptor complex components NgR and Lingo1, or by blocking the downstream effector Rho kinase (ROCK)...
- Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surfaceSheeja V Vasudevan
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 107:6847-51. 2010..With these data we predict that residues (28-58) are available to bind the Nogo receptor, which is entirely consistent with functional assays...
- Nogo-a regulates neural precursor migration in the embryonic mouse cortexCarole Mathis
Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
Cereb Cortex 20:2380-90. 2010..In vitro analysis showed that Nogo-A and its receptor components NgR, Lingo-1, TROY, and p75 are expressed in cells emigrating from embryonic forebrain-derived neurospheres...
- Axonal regeneration after optic nerve crush in Nogo-A/B/C knockout miceYing Su
Department of Ophthalmology, First Clinical College of Harbin Medical University, Harbin, China
Mol Vis 14:268-73. 2008..The axonal regeneration of retinal ganglion cells (RGCs) after optic nerve (ON) crush was investigated both in vivo and in vitro on Nogo-A/B/C knockout mice...