Nogo 66 receptor

Summary

Gene Symbol: Nogo 66 receptor
Description: reticulon 4 receptor
Alias: NOGOR, NgR, NgR1, reticulon-4 receptor, Nogo-66 receptor, nogo receptor, nogo receptor; Nogo-66 receptor, nogo66 receptor-1
Species: mouse

Top Publications

  1. doi Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration
    Chiara Rolando
    Department of Neuroscience, University of Turin, I 10126 Turin, Italy
    J Neurosci 32:17788-99. 2012
  2. pmc Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage
    Gino B Ferraro
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 286:31418-24. 2011
  3. pmc Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition
    Karthik Venkatesh
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Cell Biol 177:393-9. 2007
  4. pmc Nogo receptor 1 regulates formation of lasting memories
    Alexandra Karlén
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:20476-81. 2009
  5. pmc Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity
    Stephen J Raiker
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:12432-45. 2010
  6. doi Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor
    Lei Zhang
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Neurosci 29:6348-52. 2009
  7. pmc Nogo receptor is involved in the adhesion of dendritic cells to myelin
    Claire L McDonald
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neuroinflammation 8:113. 2011
  8. pmc Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5
    Verena Wörter
    Innsbruck Medical University, Biocenter, Division of Neurobiochemistry, Innsbruck, Austria
    PLoS ONE 4:e5218. 2009
  9. pmc Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis
    Karin Steinbach
    Institute for Neuroimmunology and Clinical MS Research, Hamburg, Germany
    PLoS ONE 6:e26341. 2011
  10. pmc Recovery from chronic spinal cord contusion after Nogo receptor intervention
    Xingxing Wang
    Cellular Neuroscience, Neurodegeneration, and Repair Program, and Department of Neurology, Yale School of Medicine, New Haven, CT 06536 0812, USA
    Ann Neurol 70:805-21. 2011

Scientific Experts

  • Juha Lauren
  • Noam Y Harel
  • THIEN T NGUYEN
  • Vincent Pernet
  • A Josephson
  • Noah L Lazar
  • Marija M Petrinovic
  • Stephen M Strittmatter
  • William B J Cafferty
  • Roman J Giger
  • Aaron W McGee
  • Yuji Kurihara
  • Xingxing Wang
  • Jing Tong
  • Stephen J Raiker
  • Ji Eun Kim
  • Jun Wang
  • Kathren L Fink
  • Ying Su
  • Martin E Schwab
  • Betty P Liu
  • Naoki Nakaya
  • Masumi Iketani
  • Kohtaro Takei
  • Yoshio Goshima
  • Larry I Benowitz
  • Yasufumi Sato
  • James H Park
  • Claire L McDonald
  • Karin Steinbach
  • Rudiger Schweigreiter
  • Ana Mingorance
  • Shuxin Li
  • Hakjoo Lee
  • Seung Wan Yoo
  • Michael G Frantz
  • Karthik Venkatesh
  • Binhai Zheng
  • Stephane Budel
  • Yinquan Fang
  • Chad S Siegel
  • Hilary M Dorton
  • Heung Sun Kwon
  • Céleste Élise Stephany
  • Srinivas Ramasamy
  • Xiaowei Wang
  • Weimin Liu
  • Jason H Huang
  • Feras V Akbik
  • Stanislav I Tomarev
  • Kuniyuki Nishiyama
  • Hiromu Ito
  • Laurie R Earls
  • Marcel M van Gaalen
  • Eun Jin Yang
  • M Kvajo
  • Chiara Rolando
  • Paschalis Theotokis
  • Zachary P Wills
  • Travis L Dickendesher
  • Fumio Nakamura
  • Omar Hasan
  • Yuko Arie
  • Gino B Ferraro
  • Roland Martin
  • Markus Reindl
  • Katherine T Baldwin
  • Eric A Huebner
  • Bor Luen Tang
  • Carole Mathis
  • Andrew Wood
  • Yuan Gao
  • Songlin Li
  • Christine E Bandtlow
  • Sheeja V Vasudevan
  • Alexandra Karlén
  • Sun On Chan
  • Peter Shrager
  • Kazunori Miyazaki
  • Yvonne S Yang
  • Lei Zhang
  • Verena Wörter
  • Hao Cui
  • Feng Wang
  • Shang Ha Pan
  • Yan Teng
  • Shi Guang Zhao
  • T M Maynard
  • Gareth Williams
  • Luc Dupuis

Detail Information

Publications74

  1. doi Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration
    Chiara Rolando
    Department of Neuroscience, University of Turin, I 10126 Turin, Italy
    J Neurosci 32:17788-99. 2012
    ..In the mouse brain, we found that the plasticity inhibitors Nogo-A and Nogo receptor 1 (NgR1) are differentially expressed in the SVZ-OB system, in which Nogo-A identifies immature neuroblasts ..
  2. pmc Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage
    Gino B Ferraro
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 286:31418-24. 2011
    Nogo-66 receptor 1 (NgR1) is a glycosylphosphatidylinositol-anchored receptor for myelin-associated inhibitors that restricts plasticity and axonal regrowth in the CNS...
  3. pmc Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition
    Karthik Venkatesh
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Cell Biol 177:393-9. 2007
    Neuronal Nogo66 receptor-1 (NgR1) binds the myelin inhibitors NogoA, OMgp, and myelin-associated glycoprotein (MAG) and has been proposed to function as the ligand-binding component of a receptor complex that also includes Lingo-1, p75(..
  4. pmc Nogo receptor 1 regulates formation of lasting memories
    Alexandra Karlén
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:20476-81. 2009
    ..We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for ..
  5. pmc Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity
    Stephen J Raiker
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:12432-45. 2010
    ..Nogo and OMgp complex with the neuronal cell surface receptors Nogo receptor-1 (NgR1) and paired Ig-like receptor-B (PirB) to regulate neuronal morphology...
  6. doi Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor
    Lei Zhang
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Neurosci 29:6348-52. 2009
    ..We hypothesize that BLyS may be a negative regulator for neuronal functions. Here Nogo-66 receptor (NgR) is identified as a high affinity receptor for BLyS, which inhibits dorsal root ganglion outgrowth in culture...
  7. pmc Nogo receptor is involved in the adhesion of dendritic cells to myelin
    Claire L McDonald
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neuroinflammation 8:113. 2011
    Nogo-66 receptor NgR1 and its structural homologue NgR2 are binding proteins for a number of myelin-associated inhibitory factors...
  8. pmc Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5
    Verena Wörter
    Innsbruck Medical University, Biocenter, Division of Neurobiochemistry, Innsbruck, Austria
    PLoS ONE 4:e5218. 2009
    ..Two members of the Nogo-receptor (NgR) family, NgR1 and NgR2, have been identified as neuronal binding proteins of MAG...
  9. pmc Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis
    Karin Steinbach
    Institute for Neuroimmunology and Clinical MS Research, Hamburg, Germany
    PLoS ONE 6:e26341. 2011
    ..b>NgR1 and NgR2 were identified as interaction partners for the myelin proteins Nogo-A, MAG and OMgp and are probably ..
  10. pmc Recovery from chronic spinal cord contusion after Nogo receptor intervention
    Xingxing Wang
    Cellular Neuroscience, Neurodegeneration, and Repair Program, and Department of Neurology, Yale School of Medicine, New Haven, CT 06536 0812, USA
    Ann Neurol 70:805-21. 2011
    ..shortly after central nervous system injury, including blockade of myelin-derived inhibitors with soluble Nogo receptor (NgR1, RTN4R) decoy protein...
  11. pmc The nogo receptor family restricts synapse number in the developing hippocampus
    Zachary P Wills
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:466-81. 2012
    ..Here we demonstrate that glycosylphosphatidylinositol-anchored cell-surface receptors of the Nogo Receptor family (NgR1, NgR2, and NgR3) restrict excitatory synapse formation...
  12. ncbi Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 mice
    Paschalis Theotokis
    B Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, Thessaloniki, Macedonia, Greece
    J Neuropathol Exp Neurol 71:907-20. 2012
    ..The results indicate that Nogo-A and Nogo receptor are actively regulated in EAE lesions; this may indicate a specific time window for localized axonal ..
  13. doi Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength
    Hakjoo Lee
    Department of Biomedical Genetics, Center for Neural Development and Disease, Interdepartmental Graduate Program for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:2753-65. 2008
    ..Members of the Nogo-66 receptor family have been implicated in regulating neuronal morphology. Nogo-66 receptor 1 (NgR1) supports binding of the myelin inhibitors Nogo-A, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte ..
  14. pmc Anatomical plasticity of adult brain is titrated by Nogo Receptor 1
    Feras V Akbik
    Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT 06536, USA
    Neuron 77:859-66. 2013
    ..examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1)...
  15. ncbi A role for Nogo receptor in macrophage clearance from injured peripheral nerve
    Elizabeth J Fry
    Center for Research in Neuroscience, The McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada
    Neuron 53:649-62. 2007
    ..Increasing numbers of macrophages in crushed rat sciatic nerves express NgR1 and NgR2 on the cell surface in the first week after injury...
  16. pmc The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth
    William B J Cafferty
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:12242-50. 2006
    The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies...
  17. pmc Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo
    Binhai Zheng
    Department of Biological Sciences, Program in Neurosciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:1205-10. 2005
    ..Neuronal Nogo receptor (NgR) binds to each of the three inhibitors and has been proposed to mediate their inhibitory signals by ..
  18. ncbi Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
    A E Fournier
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 409:341-6. 2001
    ..Nogo-66 receptor expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and its receptor provides the potential for enhanced recovery after human CNS injury...
  19. ncbi Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor
    Betty P Liu
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 297:1190-3. 2002
    ..The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor ..
  20. pmc Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins
    William A Barton
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    EMBO J 22:3291-302. 2003
    ..that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR)...
  21. ncbi Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems
    Juha Lauren
    Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Helsinki, Finland
    Mol Cell Neurosci 24:581-94. 2003
    ..Currently only the Nogo receptor (NgR), in complex with p75(NTR) neurotrophin receptor is known to be involved in this inhibitory signalling in ..
  22. ncbi Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
    Ana Mingorance
    Development and Regeneration of the CNS, Barcelona Science Park IRBB, University of Barcelona, E 08028 Barcelona, Spain
    Mol Cell Neurosci 26:34-49. 2004
    ..Here we study the onset and maturation of Nogo-A and Nogo receptor in the entorhino-hippocampal formation of developing and adult mice...
  23. ncbi Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury
    Ji Eun Kim
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 44:439-51. 2004
    ..All three of these proteins bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro...
  24. pmc Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor
    Aaron W McGee
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 309:2222-6. 2005
    ..We find that mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity...
  25. pmc Plasticity of binocularity and visual acuity are differentially limited by nogo receptor
    Céleste Élise Stephany
    Developmental Neuroscience Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California 90027
    J Neurosci 34:11631-40. 2014
    ..the plasticity of binocularity and acuity are separable and differentially regulated by the neuronal nogo receptor 1 (NgR1)...
  26. doi Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists
    Gareth Williams
    Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Biol Chem 283:16641-52. 2008
    ..In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is mediated by the sialic acid moiety ..
  27. ncbi Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact
    Xingxing Wang
    Departments of Neurology and Neurosurgery and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:5505-15. 2002
    ..An interaction of Nogo on the oligodendrocyte surface with Nogo-66 Receptor (NgR) on axons has been suggested to play an important role in limiting axonal growth...
  28. pmc Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury
    Chad S Siegel
    Department of Neurology and
    J Neurosci 35:1443-57. 2015
    ..the pathways driving spontaneous functional recovery in wild-type and plasticity-sensitized mice lacking Nogo receptor 1...
  29. pmc Nogo Receptor 1 Limits Ocular Dominance Plasticity but not Turnover of Axonal Boutons in a Model of Amblyopia
    Michael G Frantz
    Developmental Neuroscience Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Cereb Cortex 26:1975-85. 2016
    ..alter the dynamics of intracortical axonal boutons in visual cortex of either adult wild-type (WT) mice or adult NgR1 mutant (ngr1-/-) mice that retain critical period visual plasticity...
  30. doi LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand
    Yuji Kurihara
    Molecular Medical Bioscience Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, Suehiro cho 1 7 29, Tsurumi ward, Yokohama 230 0045, Japan
    Mol Cell Neurosci 61:211-8. 2014
    ..MAG), oligodendrocyte myelin glycoprotein (OMgp), and B lymphocyte stimulator (BLyS) commonly bind to Nogo receptor-1 (NgR1), leading to enormous restriction of functional recovery after damage to the adult central nervous ..
  31. pmc Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth
    Naoki Nakaya
    Section of Molecular Mechanisms of Glaucoma, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 0606, USA
    J Biol Chem 287:37171-84. 2012
    ..this study, we identified Olfm1 as a molecule promoting axon growth through interaction with the Nogo A receptor (NgR1) complex...
  32. doi NogoR1 and PirB signaling stimulates neural stem cell survival and proliferation
    Srinivas Ramasamy
    Institute of Medical Biology, 8A Biomedical Grove, 05 37 Immunos, Singapore
    Stem Cells 32:1636-48. 2014
    ..In NSCs, NogoR1 functions through Rho whereas PirB uses Shp1/2 signaling pathways to control NSC behavior. Taken together, this work suggests that Nogo signaling is an important pathway for survival of NSCs...
  33. pmc Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injury
    Jing Tong
    Department of Neurosurgery and Center for Translational Neuromedicine, University of Rochester, Rochester, New York Department of Neurosurgery, Fourth Affiliated Hospital of Hebei Medical University, Hebei, China Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, China and Department of Neurosurgery, Baylor Scott and White Health, Temple, Texas
    Neurosurgery 75:51-60. 2014
    Neuronal Nogo-66 receptor 1 (NgR1) has attracted attention as a converging point for mediating the effects of myelin-associate inhibitory ligands in the central nervous system, establishing the growth-restrictive environment, and limiting ..
  34. pmc Myocilin is involved in NgR1/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerve
    Heung Sun Kwon
    Retinal Ganglion Cell Biology Section, Laboratory of Retinal Cell and Molecular Biology and Histology Core, National Eye Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, and Neuro Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892
    J Neurosci 34:5539-51. 2014
    ..Myocilin stimulation of oligodendrocyte differentiation occurs through the NgR1/Lingo-1 receptor complex. Myocilin physically interacts with Lingo-1 and may be considered as a Lingo-1 ligand...
  35. pmc The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation
    Yinquan Fang
    From the Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tongjiaxiang Street, Nanjing 210009, China
    J Biol Chem 290:28901-14. 2015
    ..Our previous study has confirmed that Nogo receptor (NgR), an axon outgrowth inhibition receptor, is also expressed on microglia and regulates cell adhesion and ..
  36. pmc Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice
    Kathren L Fink
    Department of Neurology and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520
    J Neurosci 35:15403-18. 2015
    ..Using crym-GFP, we reevaluated the CST in mice lacking nogo receptor 1 (NgR1), a protein implicated in limiting neural repair...
  37. pmc Agenesis of the corpus callosum in Nogo receptor deficient mice
    Seung Wan Yoo
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205
    J Comp Neurol 525:291-301. 2017
    ..Imbalance of these cues results in CC agenesis or dysgenesis. Nogo receptors (NgR1, NgR2, and NgR3) are growth cone directive molecules known for inhibiting axon regeneration after injury...
  38. pmc Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches
    Ruby Hsu
    Department of Neuroscience, Columbia University, New York, New York, United States of America
    PLoS ONE 2:e1234. 2007
    b>NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.
  39. pmc Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways
    Xingxing Wang
    Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT, USA
    Exp Neurol 237:55-69. 2012
    ..of either astrocyte-derived chondroitin sulfate proteoglycans (CSPGs) or oligodendrocyte-derived NogoReceptor (NgR1) ligands reduces extrinsic inhibition of axonal growth, though combined blockade of these distinct pathways has not ..
  40. pmc NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
    Travis L Dickendesher
    Neuroscience Program, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Nat Neurosci 15:703-12. 2012
    ..The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition...
  41. pmc Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in mice
    Jing Tong
    Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurotrauma 30:247-58. 2013
    ..glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1)...
  42. doi The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1
    Yuji Kurihara
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Fuku ura 3 9, Kanazawa Ward, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 418:390-5. 2012
    Myelin-derived axon growth inhibitors, such as Nogo, bind to Nogo receptor-1 (NgR1) and thereby limit the action of axonal regeneration after injury in the adult central nervous system...
  43. doi NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance
    Marcel M van Gaalen
    Neuroscience Research, GPRD, Abbott, 67061 Ludwigshafen, Germany
    Neurosci Lett 510:58-61. 2012
    The Nogo-66 receptor (NgR1) is part of a co-receptor complex on neurons that transmits a signal for inhibition of neurite outgrowth...
  44. pmc Critical period for acoustic preference in mice
    Eun Jin Yang
    Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:17213-20. 2012
    ..Instead, exposing adult mice treated acutely with valproic acid or carrying a targeted deletion of the Nogo receptor (NgR(-/-)) unmasked a strong plasticity of preference consistent with a reopening of the critical period as ..
  45. pmc Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia
    Laurie R Earls
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosci 32:14132-44. 2012
    ..We conclude that miRNA-dependent SERCA2 dysregulation is a pathogenic event in 22q11DS and schizophrenia...
  46. pmc Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models
    M Kvajo
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Neuroscience 211:136-64. 2012
    ..Finally, we discuss emerging mouse models, such as second-generation pathophysiology models based on innovative approaches that are facilitated by the information gathered from the current genetic mouse models...
  47. pmc Nogo receptor antagonizes p75NTR-dependent motor neuron death
    Luc Dupuis
    Institut National de la Sante et de la Recherche Medicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F 67085 France
    Proc Natl Acad Sci U S A 105:740-5. 2008
    The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system...
  48. doi Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation
    Vincent Pernet
    Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:7435-44. 2008
    ..The common binding protein for Nogo-A and MAG, NgR1, was exclusively upregulated in MAG(-/-) animals, whereas the level of Lingo-1, a coreceptor, remained unchanged...
  49. doi Localization of Nogo and its receptor in the optic pathway of mouse embryos
    Jun Wang
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong Special Administrative Region, China
    J Neurosci Res 86:1721-33. 2008
    ..In vitro studies showed that the Nogo receptor (NgR) was expressed on the neurites and growth cones from both the ventral temporal and dorsal nasal quadrant ..
  50. ncbi Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration
    Cherry Ee Lin Ng
    NCA Lab, Institute of Molecular and Cell Biology, Singapore, Republic of Singapore
    J Neurosci Res 67:559-65. 2002
    ..The 66-amino acid extracellular domain of Nogo (Nogo-66) interacts with a high-affinity receptor (NgR), a glycosylphosphatidylinositol (GPI)-linked protein with multiple leucine-rich repeats...
  51. ncbi Toward simpler and faster genome-wide mutagenesis in mice
    Sen Wu
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Nat Genet 39:922-30. 2007
    ....
  52. pmc Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition
    James H Park
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:1386-95. 2006
    ..A Nogo to Nogo-66 receptor (NgR) pathway contributes to determining the ability of adult CNS axons to extend after traumatic injuries...
  53. ncbi Regeneration of lesioned entorhino-hippocampal axons in vitro by combined degradation of inhibitory proteoglycans and blockade of Nogo-66/NgR signaling
    Ana Mingorance
    Development and Regeneration of the CNS, Department of Cell Biology, IRB PCB, University of Barcelona, Barcelona, Spain
    FASEB J 20:491-3. 2006
    ..For example, NEP1-40 is a synthetic peptide that promotes axonal regeneration by blocking Nogo-66/NgR interaction and chondroitinase ABC (ChABC), which degrades CS, thereby also promoting axon regrowth...
  54. ncbi Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents?
    Felicia Yu Hsuan Teng
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, Singapore
    J Neurochem 94:865-74. 2005
    IN-1, the monoclonal antibody against the exon 3-encoded N-terminal domain of Nogo-A, and the Nogo-66 receptor (NgR) antagonist NEP1-40 have both shown efficacy in promoting regeneration in animal spinal cord injury models, the latter ..
  55. pmc Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury
    Shuxin Li
    Department of Neurology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06510, USA
    Mol Cell Neurosci 29:26-39. 2005
    ..after spinal injury is thought to be limited in part by myelin-derived proteins that act via the Nogo-66 Receptor (NgR)...
  56. ncbi Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury
    Shuxin Li
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 23:4219-27. 2003
    ..oligodendrocyte-myelin glycoprotein, and myelin-associated glycoprotein, all bind to an axonal Nogo-66 receptor (NgR) and at least partially account for this lack of CNS repair...
  57. ncbi Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans
    Anna Josephson
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Comp Neurol 453:292-304. 2002
    ....
  58. pmc Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci 29:13850-9. 2009
    ..Our results provide a novel intracellular role for reticulon proteins and support the hypothesis that modulation of PDI function is a potential therapeutic approach to ALS...
  59. pmc Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes
    T M Maynard
    Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Mol Cell Neurosci 39:439-51. 2008
    ..Our results suggest that altered dosage of one, or several 22q11 mitochondrial genes, particularly during early post-natal cortical development, may disrupt neuronal metabolism or synaptic signaling...
  60. pmc Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth
    Stephane Budel
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Neurosci 28:13161-72. 2008
    ..Neuronal cultures demonstrate that four different schizophrenia-derived NgR1 variants fail to transduce myelin signals into axon inhibition, and function as dominant negatives to disrupt ..
  61. pmc Axonal protective effects of the myelin-associated glycoprotein
    Thien Nguyen
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci 29:630-7. 2009
    ..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss...
  62. doi Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice
    Kazunori Miyazaki
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 31:316-21. 2009
    Detailed assessment of Nogo-A and its receptor NgR in the spinal cord of amyotrophic lateral sclerosis (ALS) models or patients has not been reported previously, and we examined the expression and distribution patterns of Nogo-A and NgR ..
  63. doi Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells
    Yuan Gao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People s Republic of China
    Stem Cells Dev 19:53-60. 2010
    ..However, its expression regulation largely remains unknown. In this study we show that Nogo receptor (NgR) participates in the regulation of Nanog expression via Stat3 pathway...
  64. pmc Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation
    Yasufumi Sato
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Science 333:769-73. 2011
    ..We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein...
  65. doi Axonal regeneration of optic nerve after crush in Nogo66 receptor knockout mice
    Ying Su
    Department of Ophthalmology, First Clinical College of Harbin Medical University, Harbin 150001, China
    Neurosci Lett 460:223-6. 2009
    ..myelin-associated glycoprotein (MAG) and Omgp, exert their effects on neuron regeneration through the Nogo receptor (NgR)...
  66. doi Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice
    Noah L Lazar
    Department of Psychology, University of Western Ontario, London, ON, Canada
    Behav Brain Res 224:73-9. 2011
    ..Given the mild effect of the R189H mutation of Rtn4r on behavioural phenotypes relevant to schizophrenia, our results do not support missense mutation of RTN4R as a strong risk factor in the pathogenesis of schizophrenia...
  67. pmc A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1
    Eric A Huebner
    Department of Neurology and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 286:18026-36. 2011
    ..Three regions of Nogo-A (Nogo-A-24, Nogo-66, and Nogo-C39) interact with the neuronal Nogo-66 receptor 1 (NgR1)...
  68. pmc An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
    Songlin Li
    Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Nat Neurosci 13:1496-504. 2010
    ..This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery...
  69. doi Localization of an axon growth inhibitory molecule Nogo and its receptor in the spinal cord of mouse embryos
    Jun Wang
    Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University, Beijing, China
    Brain Res 1306:8-17. 2010
    The localization of an axon growth inhibitory molecule Nogo and its receptor (NgR) was investigated in the mouse spinal cord during prenatal development of the commissural pathway...
  70. pmc Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury
    Noam Y Harel
    Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Neurotrauma 27:2055-66. 2010
    ..Genetically, we reduced myelin-mediated inhibition of neural plasticity through Nogo66-receptor (NgR) gene deletion. Behaviorally, we utilized a novel multimodal exercise training paradigm...
  71. doi Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system
    Marija M Petrinovic
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 137:2539-50. 2010
    ..The same effects are seen with antibodies against the Nogo receptor complex components NgR and Lingo1, or by blocking the downstream effector Rho kinase (ROCK)...
  72. pmc Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface
    Sheeja V Vasudevan
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:6847-51. 2010
    ..With these data we predict that residues (28-58) are available to bind the Nogo receptor, which is entirely consistent with functional assays...
  73. pmc Nogo-a regulates neural precursor migration in the embryonic mouse cortex
    Carole Mathis
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    Cereb Cortex 20:2380-90. 2010
    ..In vitro analysis showed that Nogo-A and its receptor components NgR, Lingo-1, TROY, and p75 are expressed in cells emigrating from embryonic forebrain-derived neurospheres...
  74. pmc Axonal regeneration after optic nerve crush in Nogo-A/B/C knockout mice
    Ying Su
    Department of Ophthalmology, First Clinical College of Harbin Medical University, Harbin, China
    Mol Vis 14:268-73. 2008
    ..The axonal regeneration of retinal ganglion cells (RGCs) after optic nerve (ON) crush was investigated both in vivo and in vitro on Nogo-A/B/C knockout mice...