Nodal

Summary

Gene Symbol: Nodal
Description: nodal
Alias: Tg.413d, nodal
Species: mouse

Top Publications

  1. doi Inhibition of Nodal suppresses angiogenesis and growth of human gliomas
    Dueng Yuan Hueng
    Department of Neurological Surgery, Tri Service General Hospital, National Defense Medical Center, 325, Sec 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, ROC
    J Neurooncol 104:21-31. 2011
  2. ncbi The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants
    J A Belo
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Mech Dev 72:15-25. 1998
  3. pmc Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
    Shannon E Powers
    Department of Biochemistry and Molecular Genetics, and Center for Cell Signaling, University of Virginia, Box 800577, HSC, Charlottesville VA 22908, USA
    Development 137:249-59. 2010
  4. ncbi The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
    N S Murcia
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 127:2347-55. 2000
  5. ncbi Axis development and early asymmetry in mammals
    R S Beddington
    Division of Mammalian Development, MRC National Institute for Medical Research, The Ridgeway, London, United Kingdom
    Cell 96:195-209. 1999
  6. ncbi A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
    F L Conlon
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
    Development 120:1919-28. 1994
  7. ncbi Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation
    X Zhou
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Nature 361:543-7. 1993
  8. pmc Wnt3a links left-right determination with segmentation and anteroposterior axis elongation
    Masa aki Nakaya
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH Frederick, MD 21702, USA
    Development 132:5425-36. 2005
  9. ncbi Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo
    Ana Teresa Tavares
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Development 134:2051-60. 2007
  10. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. doi Inhibition of Nodal suppresses angiogenesis and growth of human gliomas
    Dueng Yuan Hueng
    Department of Neurological Surgery, Tri Service General Hospital, National Defense Medical Center, 325, Sec 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, ROC
    J Neurooncol 104:21-31. 2011
    ..We previously reported that expression levels of Nodal, a member of transforming growth factor-β super family, correlate with the malignant invasive behavior of human ..
  2. ncbi The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants
    J A Belo
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Mech Dev 72:15-25. 1998
    ..The role of Gsc-1 during gastrulation and axial development is discussed in relation to possible compensatory interactions with other genes such as HNF-3beta and the recently identified Gsc-2 and Gsc-3 genes...
  3. pmc Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
    Shannon E Powers
    Department of Biochemistry and Molecular Genetics, and Center for Cell Signaling, University of Virginia, Box 800577, HSC, Charlottesville VA 22908, USA
    Development 137:249-59. 2010
    ..TGIF1 are associated with holoprosencephaly, but it is unclear whether this is a result of deregulation of TGFbeta/Nodal signaling, or of effects on other pathways...
  4. ncbi The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
    N S Murcia
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 127:2347-55. 2000
    ..At mid-gestation the direction of heart looping is randomized, and at earlier stages in development lefty-2 and nodal, which are normally expressed asymmetrically, exhibit symmetrical expression in the mutant embryos...
  5. ncbi Axis development and early asymmetry in mammals
    R S Beddington
    Division of Mammalian Development, MRC National Institute for Medical Research, The Ridgeway, London, United Kingdom
    Cell 96:195-209. 1999
  6. ncbi A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
    F L Conlon
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
    Development 120:1919-28. 1994
    The 413.d insertional mutation arrests mouse development shortly after gastrulation. nodal, a novel TGF beta-related gene, is closely associated with the locus...
  7. ncbi Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation
    X Zhou
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Nature 361:543-7. 1993
    ..Our findings suggest that this gene, named nodal, encodes a signalling molecule essential for mesoderm formation and subsequent organization of axial structures in ..
  8. pmc Wnt3a links left-right determination with segmentation and anteroposterior axis elongation
    Masa aki Nakaya
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH Frederick, MD 21702, USA
    Development 132:5425-36. 2005
    ..Wnt3a activates the Delta/Notch pathway to regulate perinodal expression of the left determinant Nodal, while simultaneously controlling the segmentation clock and the molecular oscillations of the Wnt/beta-catenin ..
  9. ncbi Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo
    Ana Teresa Tavares
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Development 134:2051-60. 2007
    The TGF-beta-related molecule Nodal plays an essential and conserved role in left-right patterning of the vertebrate embryo...
  10. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007
    ..Unexpectedly, co-expression with Nodal - another TGF-beta superfamily ligand involved in mesoderm formation - could also expose the activities of native ..
  11. ncbi Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
    C M Jones
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Development 121:3651-62. 1995
    Mouse embryos homozygous for a null mutation in nodal arrest development at early gastrulation and contain little or no embryonic mesoderm...
  12. ncbi Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus
    L A Lowe
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 381:158-61. 1996
    ..chick embryo revealed L-R asymmetric expression of several previously cloned genes, including Cnr-1 (for chicken nodal-related-1), and indicated how this L-R molecular asymmetry might be important for subsequent visceral ..
  13. ncbi nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
    I Varlet
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 124:1033-44. 1997
    Mouse nodal, a member of the TGFbeta family of secreted growth factors is essential for gastrulation. We recently generated a nodal(lacZ) reporter allele by homologous recombination in ES cells...
  14. ncbi lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
    C Meno
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan
    Cell 94:287-97. 1998
    lefty-1, lefty-2, and nodal are expressed on the left side of developing mouse embryos and are implicated in left-right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene...
  15. pmc Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer
    H Adachi
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565, Japan
    Genes Dev 13:1589-600. 1999
    The nodal gene is expressed on the left side of developing mouse embryos and is implicated in left/right (L-R) axis formation. The transcriptional regulatory regions of nodal have now been investigated by transgenic analysis...
  16. pmc Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1
    T Tsukui
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
    Proc Natl Acad Sci U S A 96:11376-81. 1999
    ..Thus, the roles of Shh and RA in left-right specification indeed are conserved among vertebrates, and the Shh and RA pathways converge in the control of Lefty-1...
  17. ncbi Nodal signalling in vertebrate development
    A F Schier
    Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Nature 403:385-9. 2000
    ..Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor beta-related signal, is responsible for many of the events that configure the ..
  18. ncbi Regulation of left-right patterning in mice by growth/differentiation factor-1
    C T Rankin
    Department of Molecular Biology and Genetics, Baltimore, Maryland, USA
    Nat Genet 24:262-5. 2000
    ..the expression of Ebaf (formerly lefty-1) in the left side of the floor plate and Leftb (formerly lefty-2), nodal and Pitx2 in the left lateral plate mesoderm was absent, suggesting that Gdf1 acts upstream of these genes either ..
  19. ncbi The cerberus-related gene, Cerr1, is not essential for mouse head formation
    W Shawlot
    Genesis 26:253-8. 2000
    ..These findings suggest that establishment of anterior identity in the mouse may involve the action of multiple functionally redundant factors...
  20. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..The transforming growth factor-beta family member Nodal is known to be required for formation of the anterior-posterior axis...
  21. pmc Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells
    Caterina Bianco
    Tumor Growth Factor Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:2586-97. 2002
    ..Recently, EGF-CFC proteins were implicated as essential signaling cofactors for Nodal, a transforming growth factor beta family member whose expression has previously been defined as embryo specific...
  22. ncbi Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks
    Aitana Perea-Gomez
    IGBMC CNRS INSERM, Universite Louis Pasteur, 67404 Illkirch Cedex, CU de, Strasbourg, France
    Dev Cell 3:745-56. 2002
    ..extraembryonic, cells but is rescued in Cerberus-like(-/-); Lefty1(-/-) embryos after removal of one copy of the Nodal gene...
  23. ncbi Extraembryonic proteases regulate Nodal signalling during gastrulation
    Séverine Beck
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 4:981-5. 2002
    ..This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral ..
  24. pmc The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
    Sara Marques
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Genes Dev 18:2342-7. 2004
    ..left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM)...
  25. ncbi Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
    Chiharu Kimura-Yoshida
    Vertebrate Body Plan Group, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minami cho, Chuou ku Kobe, Hyogo 650 0047, Japan
    Dev Cell 9:639-50. 2005
    ..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
  26. ncbi Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
    Anne Camus
    Laboratoire de Développement des Vertébrés, Institut Jacques Monod UMR 7592 CNRS, Universités Paris 6 et 7, 2 place Jussieu, 75251 Paris, France
    Dev Biol 295:743-55. 2006
    After implantation, mouse embryos deficient for the activity of the transforming growth factor-beta member Nodal fail to form both the mesoderm and the definitive endoderm...
  27. pmc Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
    Marie Hélène Blanchet
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Epalinges, Switzerland
    EMBO J 27:2580-91. 2008
    The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described...
  28. ncbi A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration
    F L Conlon
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Development 111:969-81. 1991
    ..These results indicate that the homozygous mutant cells can be effectively 'rescued' by the presence of wild-type cells in a carrier embryo...
  29. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    ..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
  30. ncbi Relationship between asymmetric nodal expression and the direction of embryonic turning
    J Collignon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 381:155-8. 1996
    ..One such family member, nodal, is required for formation of the primitive streak during mouse gastrulation...
  31. pmc The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    C Sirard
    Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 12:107-19. 1998
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
  32. ncbi Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    M Nomura
    Cardiovascular Research Center, Massachusetts General Hospital East, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Nature 393:786-90. 1998
    ..In Xenopus, Smad2 can induce dorsal mesoderm, mimicking Vg-1, activin and nodal. Here we investigate the function of Smad2 in mammalian development by generating two independent Smad2 mutant ..
  33. ncbi The role of the brachyury gene in heart development and left-right specification in the mouse
    T King
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, UK
    Mech Dev 79:29-37. 1998
    ..Three TGF-beta related genes, lefty-1, lefty-2 and nodal, are expressed asymmetrically in mouse embryos, and are implicated in the development of situs...
  34. pmc Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements
    D P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, Massachusetts 02138, USA
    Genes Dev 13:1575-88. 1999
    The TGFbeta-related molecule Nodal is required for establishment of the anterior-posterior (A-P) and left-right (L-R) body axes of the vertebrate embryo...
  35. ncbi Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH
    E N Meyers
    Department of Anatomy and Program in Developmental Biology, School of Medicine, and Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Science 285:403-6. 1999
    ..In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right...
  36. ncbi Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
    C Meno
    Division of Molecular Biology, Osaka University, Japan
    Mol Cell 4:287-98. 1999
    ..expanded primitive streak and form excess mesoderm, a phenotype opposite to that of mutants for the TGF beta gene nodal. Analogously, overexpression of Antivin or Lefty2 in zebrafish embryos blocks head and trunk mesoderm formation, a ..
  37. ncbi Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
    Y Saijoh
    Division of Molecular Biology, Osaka University, Japan
    Mol Cell 5:35-47. 2000
    The left-right (L-R) asymmetric expression of lefty2 and nodal is controlled by a left side-specific enhancer (ASE)...
  38. pmc SPC4/PACE4 regulates a TGFbeta signaling network during axis formation
    D B Constam
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 USA
    Genes Dev 14:1146-55. 2000
    ..specification of anteroposterior (A/P) and left-right (L/R) axes depends on TGFbeta-related signals, including Nodal, Lefty, and BMPs...
  39. ncbi Genetic dissection of nodal function in patterning the mouse embryo
    L A Lowe
    Experimental Immunology Branch, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Development 128:1831-43. 2001
    Loss-of-function analysis has shown that the transforming growth factor-like signaling molecule nodal is essential for mouse mesoderm development...
  40. pmc The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
    M Yamamoto
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
    Genes Dev 15:1242-56. 2001
    FoxH1 (FAST) is a transcription factor that mediates signaling by transforming growth factor-beta, Activin, and Nodal. The role of FoxH1 in development has now been investigated by the generation and analysis of FoxH1-deficient (FoxH1(-/-..
  41. pmc FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
    P A Hoodless
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Genes Dev 15:1257-71. 2001
    ..Activin/nodal signaling through the Smad2 pathway has been implicated in AVE formation and in morphogenesis of the primitive ..
  42. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 105:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis.[Dedicated to Rosa Beddington, a pioneer in mammalian embryology]...
  43. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis...
  44. ncbi Establishment of vertebrate left-right asymmetry
    Hiroshi Hamada
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, and CREST, Japan
    Nat Rev Genet 3:103-13. 2002
    ..Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating ..
  45. pmc Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
    Yu Ting Yan
    Center for Advanced Biotechnology and Medicine and Department of Pediatric, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 22:4439-49. 2002
    ..that has been implicated in the signaling pathway for the transforming growth factor beta (TGF beta) ligand Nodal. Although recent findings in frog and fish embryos have suggested that EGF-CFC proteins function as coreceptors ..
  46. ncbi The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
    Dominic P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
    Development 129:3455-68. 2002
    The TGFbeta-related growth factor Nodal governs anteroposterior (AP) and left-right (LR) axis formation in the vertebrate embryo...
  47. ncbi Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
    Adam H Hart
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, VIC 3050, Australia
    Development 129:3597-608. 2002
    ..Mixl1 is therefore required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis...
  48. pmc Nodal activity in the node governs left-right asymmetry
    Jane Brennan
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2339-44. 2002
    b>Nodal is expressed at the lateral edges of the mouse node, but its function in this "organizer" tissue remains unknown due to the early lethality of Nodal mutant embryos...
  49. ncbi Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
    Yong Ma
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 111:63-75. 2002
    ..This activity is disrupted by alteration of residues functionally conserved in Patched and in a related family of bacterial transmembrane transporters, thus suggesting similar mechanisms of action for all of these proteins...
  50. ncbi Left-right patterning of the mouse lateral plate requires nodal produced in the node
    Yukio Saijoh
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Osaka 565 0871, Suita, Japan
    Dev Biol 256:160-72. 2003
    ..Mice homozygous for a hypomorphic Nodal allele (Nodal(neo)) were generated and found to exhibit L-R defects, including right isomerism...
  51. pmc Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos
    Angel Raya
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 17:1213-8. 2003
    Left-sided expression of Nodal in the lateral plate mesoderm is a conserved feature necessary for the establishment of normal left-right asymmetry during vertebrate embryogenesis...
  52. pmc Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 17:1207-12. 2003
    ..plays a primary role in the establishment of left-right asymmetry in mice by directly regulating expression of the Nodal gene...
  53. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  54. ncbi Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
    Masamichi Yamamoto
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 428:387-92. 2004
    ..Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE...
  55. ncbi Two modes by which Lefty proteins inhibit nodal signaling
    Canhe Chen
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Curr Biol 14:618-24. 2004
    ..Transforming Growth Factor-beta (TGFbeta) proteins act as extracellular antagonists of the signaling pathway for Nodal, a TGFbeta-related ligand essential for mesendoderm formation and left-right patterning...
  56. ncbi Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    Cindy C Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 273:149-59. 2004
    The TGFbeta family member Nodal has been shown to be involved in a variety of processes in development, including early axis formation...
  57. pmc ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse
    Henrik Jörnvall
    Department of Neuroscience, Karolinska Institute, Retzius vag 8, S 17177 Stockholm, Sweden
    Mol Cell Biol 24:9383-9. 2004
    ..development depend upon selected members of the transforming growth factor beta superfamily, particularly Nodal and Nodal-related ligands...
  58. ncbi Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Science 308:563-6. 2005
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos...
  59. ncbi Overexpression of Nodal promotes differentiation of mouse embryonic stem cells into mesoderm and endoderm at the expense of neuroectoderm formation
    Kristina C Pfendler
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA 94143, USA
    Stem Cells Dev 14:162-72. 2005
    ..of ES cells into the embryonic germ layers is the transforming growth factor-beta (TGF-beta) growth factor, Nodal. Nodal null mouse mutants lack mesoderm, and injection of Nodal mRNA into nonmammalian embryos induces mesodermal ..
  60. pmc Cilia and Hedgehog responsiveness in the mouse
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:11325-30. 2005
    ....
  61. ncbi Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia
    Christina Karcher
    Institut für Zoologie 220, Universitat Hohenheim, Garbenstr 30, D 70593 Stuttgart, Germany
    Differentiation 73:425-32. 2005
    ..placement of thoracic and abdominal organs in the vertebrates is controlled by the left-asymmetric activity of the Nodal signaling cascade during embryogenesis...
  62. ncbi The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo
    Canhe Chen
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 133:319-29. 2006
    ..member Gdf3 (growth-differentiation factor 3), a close relative of Xenopus Vg1, resembles the Tgfbeta ligand Nodal in both its signaling activity and its role in AVE formation in vivo...
  63. ncbi The mouse embryo autonomously acquires anterior-posterior polarity at implantation
    Katsuyoshi Takaoka
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Cell 10:451-9. 2006
    ..Here we report an asymmetry in the mouse embryo at an unexpectedly early stage. The gene for Lefty1, a Nodal antagonist that influences the direction of DVE migration, was found to be asymmetrically expressed in the ..
  64. ncbi The left-right axis in the mouse: from origin to morphology
    Hidetaka Shiratori
    Developmental Genetics Group, Graduate School for Frontier Biosciences, Osaka University, Japan Science and Technology Corporation
    Development 133:2095-104. 2006
    ..Although a leftward flow of extra-embryonic fluid in the node cavity (nodal flow) is likely to be the symmetry-breaking event, at least in the mouse embryo, it is not yet known how this flow ..
  65. pmc Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:10300-4. 2006
    ....
  66. ncbi Disruption of early proximodistal patterning and AVE formation in Apc mutants
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Development 133:3379-87. 2006
    ..Both Nodal and Wnt signaling pathways are involved in these events...
  67. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..Furin and PACE4 pattern the primitive ectoderm and visceral endoderm, presumably by activating the TGFss-related Nodal precursor...
  68. ncbi Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryo
    Martin Blum
    Institute of Zoology, University of Hohenheim, D 70593 Stuttgart, Germany
    Differentiation 75:133-46. 2007
    ..Expression of Nodal, a gene intricately involved in the determination of vertebrate laterality, delineates the wide plate-like ..
  69. ncbi Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells
    Masanori Takenaga
    Department of Gastroenterological Surgery, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Cell Sci 120:2078-90. 2007
    b>Nodal signaling induces the formation of the endoderm and mesoderm during gastrulation. Nodal expression persists until the definitive endoderm progenitor has completely formed, and disappears thereafter...
  70. ncbi Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo
    Shinya Oki
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST Yamada oka, Suita, Osaka 565 0871, Japan
    Development 134:3893-904. 2007
    ..in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM)...
  71. ncbi Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms
    Yojiro Yamanaka
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 13:884-96. 2007
    ..Therefore, we propose three distinct regions within the mouse notochord, each with unique morphogenetic origins...
  72. ncbi Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal
    Jonathan A Kelber
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 283:4490-500. 2008
    ..Cripto is required for signaling by certain transforming growth factor-beta superfamily members, such as Nodal, but also antagonizes others, such as activin...
  73. doi BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment
    Naoki Mine
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:2425-34. 2008
    In mouse, left-right (L-R) patterning depends on asymmetric expression of Nodal around the node, leading to Nodal expression specifically in the left lateral plate mesoderm (LPM)...
  74. pmc Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling
    Anna Katerina Hadjantonakis
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS ONE 3:e2511. 2008
    ..Here we describe a novel role for the T-box transcription factor gene Tbx6 in left/right body axis determination in the mouse...
  75. pmc Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo
    María J García-García
    Molecular Biology and Genetics Department, Cornell University, Ithaca, NY 14853, USA
    Development 135:3053-62. 2008
    ....
  76. pmc GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses
    Ariel J Levine
    Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY, USA
    Dev Biol 325:43-8. 2009
    ..TGF-beta superfamily, there are approximately forty ligands divided into two major branches: the TGF-beta/Activin/Nodal ligands and the BMP/GDF ligands...
  77. doi Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow
    Charlotte Maisonneuve
    Ecole Polytechnique Federale de Lausanne, Station 19, Lausanne, Switzerland
    Development 136:3019-30. 2009
    ..These results suggest a model whereby BicC links the orientation of cilia with PCP, possibly by regulating RNA silencing in P-bodies...
  78. doi Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos
    Shinya Oki
    Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Development 136:3917-25. 2009
    ..In the node of wild-type embryos, the expression of Nodal and Cerl2 (Dand5), which encodes an inhibitor of Nodal, is asymmetric, with the level of Nodal expression being ..
  79. pmc Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells
    Katherine E Galvin
    Department of Pathology and Laboratory Medicine and Division of Cancer and Developmental Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 285:19747-56. 2010
    ..bone morphogenic proteins (BMPs) maintain pluripotency of undifferentiated mouse ES cells, the role of autocrine Nodal signaling is less clear...
  80. doi Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes
    Øyvind Dahle
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Sci Signal 3:ra48. 2010
    ..Here, we show that a key function of the developmentally essential Nodal-Smads2/3 (Smad2 and Smad3) signaling pathway is to recruit the histone demethylase Jmjd3 to target genes, thereby ..
  81. pmc Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse
    Isabelle Migeotte
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 8:e1000442. 2010
    ..The anterior visceral endoderm (AVE) is a cluster of extra-embryonic cells that secretes inhibitors of the Wnt and Nodal pathways to inhibit posterior development...
  82. doi Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo
    Céline Granier
    Universite Paris Diderot, CNRS, Institut Jacques Monod, UMR 7592, Development and Neurobiology programme, F 75013 Paris, France
    Dev Biol 349:350-62. 2011
    b>Nodal, a secreted factor known for its conserved functions in cell-fate specification and the establishment of embryonic axes, is also required in mammals to maintain the pluripotency of the epiblast, the tissue that gives rise to all ..
  83. pmc Nodal expression in the uterus of the mouse is regulated by the embryo and correlates with implantation
    Craig B Park
    Division of Experimental Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Biol Reprod 84:1103-10. 2011
    b>Nodal, a transforming growth factor beta (TGFB) superfamily member, plays a critical role during early embryonic development...
  84. pmc Nodal dependent differential localisation of dishevelled-2 demarcates regions of differing cell behaviour in the visceral endoderm
    Georgios Trichas
    Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, United Kingdom
    PLoS Biol 9:e1001019. 2011
    ..In Nodal null embryos, membrane localisation of Dvl2 is reduced, while in mutants for the Nodal inhibitor Lefty1, Dvl2 is ..
  85. pmc Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos
    Aiko Kawasumi
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 353:321-30. 2011
    ..Dissection of ANE revealed that it is activated in the perinodal cells on the left side by Nodal signaling, suggesting that Nodal activity in the node is asymmetric at a time when Nodal expression is symmetric...
  86. doi Nodal signaling regulates the entry into meiosis in fetal germ cells
    Benoit Souquet
    Commissariat à l Energie Atomique CEA Direction des Science du Vivant DSV, institut de radiobiologie cellulaire et moléculaire IRCM, Service Cellules Souches et Radiation SCSR, Laboratoire de Développement des Gonades LDG, Universite Paris Diderot, Sorbonne Paris Cité, France
    Endocrinology 153:2466-73. 2012
    ..We investigated the involvement of the TGF-β family members in fetal germ cell meiosis initiation. Nodal, a member of the TGF-β family, and its target genes are precociously expressed in embryonic gonads and show ..
  87. doi Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia
    Christine E Larkins
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    Dev Biol 367:15-24. 2012
    ..This flow is followed by asymmetric expression of Nodal and its inhibitor Cerl2 in the node...
  88. ncbi The ion channel polycystin-2 is required for left-right axis determination in mice
    Petra Pennekamp
    Universitatsklinikum Munster, Institut fur Humangenetik, Vesaliusweg 12 14, Germany
    Curr Biol 12:938-43. 2002
    Generation of laterality depends on a pathway which involves the asymmetrically expressed genes nodal, Ebaf, Leftb, and Pitx2. In mouse, node monocilia are required upstream of the nodal cascade...
  89. ncbi Node and midline defects are associated with left-right development in Delta1 mutant embryos
    Gerhard K H Przemeck
    GSF, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    Development 130:3-13. 2003
    ..Based on expression analysis in wild-type and mutant embryos, we suggest a model, in which Notch signalling is required for the proper differentiation of node cells and node morphology...
  90. pmc Cell fate decisions within the mouse organizer are governed by graded Nodal signals
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 17:1646-62. 2003
    ..Previous studies suggest that signaling pathways activated by Nodal, bone morphogenetic protein (BMP), and Wnt ligands coordinately regulate patterning of the streak and the ..
  91. pmc Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover
    Konstantinos J Mavrakis
    Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    PLoS Biol 5:e67. 2007
    ..We have shown that Arkadia, a nuclear RING-domain E3 ubiquitin ligase, is essential for a subset of Nodal functions in the embryo, but the molecular mechanism of its action in embryonic cells had not been addressed...
  92. pmc The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development
    N Gotoh
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Biol 25:4105-16. 2005
    ..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis...
  93. pmc Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
    Genes Dev 23:1689-98. 2009
    ..show that mice lacking all three CYP26 genes manifest duplication of the body axis as a result of expansion of the Nodal expression domain throughout the epiblast...
  94. ncbi Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles
    S Cereghini
    Unité de Génétique de la Différenciation, UA 1149 du CNRS, Institut Pasteur, Paris, France
    Development 116:783-97. 1992
    ..Our results also provide evidence of a posttranscriptional level of control of vHNF1 and HNF1 gene expression during development, in addition to the spatial restriction in transcription...
  95. ncbi Mapping in the region of Danforth's short tail and the localization of tail length modifiers
    J B Alfred
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Genome Res 7:108-17. 1997
    ..This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.
  96. ncbi X-linked situs abnormalities result from mutations in ZIC3
    M Gebbia
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Nat Genet 17:305-8. 1997
    ..ZIC3, which has not been previously implicated in vertebrate LR-axis development, is the first gene unequivocally associated with human situs abnormalities...
  97. ncbi No turning, a mouse mutation causing left-right and axial patterning defects
    P G Melloy
    Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Dev Biol 193:77-89. 1998
    ..Interestingly, in nt embryos, the direction of heart looping was randomized. Nodal and lefty, two genes that are normally expressed only in the left lateral plate mesoderm, show expression in the ..
  98. ncbi Molecular mechanisms of vertebrate left-right development
    A F Ramsdell
    Trends Genet 14:459-65. 1998
    ....
  99. ncbi The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives
    C Tomihara-Newberger
    Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, New York, 10021, USA
    Dev Biol 204:34-54. 1998
    ....
  100. ncbi The SIL gene is required for mouse embryonic axial development and left-right specification
    S Izraeli
    Genetics Department, Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20889 5105, USA
    Nature 399:691-4. 1999
    ..indicates that the consequences of abnormal midline development for left-right patterning depend on the time of onset, duration and severity of disruption of the normal asymmetric patterns of expression of nodal, lefty-2 and Pitx2.
  101. ncbi The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
    J Song
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Dev Biol 213:157-69. 1999
    ..Interestingly, we observed similar gastrulation defects in ActRIIA(-/-)nodal(+/-) double mutants, which, if they developed beyond the gastrulation stage, displayed rostral head defects and ..