Nod2

Summary

Gene Symbol: Nod2
Description: nucleotide-binding oligomerization domain containing 2
Alias: ACUG, BLAU, Card15, F830032C23Rik, IBD1, Nlrc2, nucleotide-binding oligomerization domain-containing protein 2, caspase recruitment domain family, member 15, caspase recruitment domain-containing protein 15
Species: mouse

Top Publications

  1. ncbi Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria
    Constance A M Finney
    Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Trop Med Hyg 80:718-22. 2009
  2. pmc NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:12873-8. 2009
  3. pmc Critical role of NOD2 in regulating the immune response to Staphylococcus aureus
    Hitesh S Deshmukh
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Infect Immun 77:1376-82. 2009
  4. pmc Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    Immunity 34:75-84. 2011
  5. ncbi Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes
    Thorsten Stroh
    Department of Medicine I, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 181:3620-7. 2008
  6. pmc NOD2 mediates inflammatory responses of primary murine glia to Streptococcus pneumoniae
    Xinjie Liu
    Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    Glia 58:839-47. 2010
  7. pmc Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model
    Kaoru Geddes
    Department of Immunology, University of Toronto, Toronto, Ontario M6G 2T6, Canada
    Infect Immun 78:5107-15. 2010
  8. pmc Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1739-45. 2009
  9. doi Immunohistochemical detection of NOD1 and NOD2 in the healthy murine and canine eye
    Emma Scurrell
    Department of Pathology and Infectious Diseases, The Royal Veterinary College, Hawkshead Lane, Herts, UK
    Vet Ophthalmol 12:269-75. 2009
  10. pmc Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    Amlan Biswas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14739-44. 2010

Research Grants

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
  2. Bacterial infection induces cytokine production
    Ian Marriott; Fiscal Year: 2003
  3. Osteoblast-derived inflammatory mediators in infection
    Ian Marriott; Fiscal Year: 2004
  4. RIP2 kinase's function in Innate Immunity
    Derek Abbott; Fiscal Year: 2007

Scientific Experts

  • HOLLY LALLMAN ROSENZWEIG
  • Aitak Farzi
  • Nobuhiko Kayagaki
  • Catherine Werts
  • Emma Scurrell
  • Li Chung Hsu
  • Leo A B Joosten
  • Sandip K Datta
  • Taku Fujimura
  • Sylvie Legrand-Poels
  • Louise Hjerrild Zeuthen
  • Jill A Poole
  • Marcelo Paez-Pereda
  • Ian Marriott
  • Chung Hang Leung
  • Derek Abbott
  • Gabriel Nunez
  • Yun Gi Kim
  • Stephen E Girardin
  • Dana J Philpott
  • Koichi S Kobayashi
  • Peter J Murray
  • Thirumahal Selvanantham
  • Lionel Le Bourhis
  • Luigi Franchi
  • Tomohiro Watanabe
  • Jong Hwan Park
  • Joao G Magalhaes
  • Leonardo H Travassos
  • Yasunori Ogura
  • Frederick Barreau
  • Richard A Flavell
  • Jean Pierre Hugot
  • Lars Eckmann
  • Shizuo Akira
  • Christine McDonald
  • Justine T Tigno-Aranjuez
  • Naohiro Inohara
  • Xinjie Liu
  • Amlan Biswas
  • Kaoru Geddes
  • Vinita S Chauhan
  • Michael H Shaw
  • Noemi Marina-Garcia
  • Philip Rosenstiel
  • Ulrich Meinzer
  • Dominique Berrebi
  • Thirumala Devi Kanneganti
  • Gerben Ferwerda
  • Mathias Chamaillard
  • Atsushi Kitani
  • Warren Strober
  • Kimberly M Davis
  • Mizuho Hasegawa
  • Stefan Schreiber
  • Jörg H Fritz
  • Francois Coulombe
  • Ghislaine Sterkers
  • Joao Gamelas Magalhaes
  • Thecla Lesuffleur
  • Maziar Divangahi
  • Stephane Bonacorsi
  • Monique Dussaillant
  • Yibin Yang
  • Marco Giovannini
  • Fabrice Chareyre
  • Mathilde Body-Malapel
  • Michael Karin
  • Ivan J Fuss
  • Vincent Ollendorff
  • Partho Chattoraj
  • Aurélie Couturier-Maillard
  • Balamayooran Theivanthiran
  • Ida H Hiemstra
  • Jonathan D Schertzer
  • Bráulia C Caetano
  • Patrick J Shaw
  • Kushagra Bansal
  • Wen Hsiang Tsai
  • Guillaume Dalmasso
  • Jill M Marinis
  • Jinghua Wang
  • Michela Manni
  • Nobuhiko Kamada
  • Dario S Zamboni
  • Jeffrey N Weiser
  • Tak W Mak
  • William R Berrington
  • Thornik Reimer
  • Claudia Toma

Detail Information

Publications119 found, 100 shown here

  1. ncbi Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria
    Constance A M Finney
    Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Trop Med Hyg 80:718-22. 2009
    ..We therefore demonstrate for the first time that Nod proteins are activated in response to parasites, and they play a role in regulating host inflammatory responses during malaria infection...
  2. pmc NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:12873-8. 2009
    ..aureus in vitro, but the physiological significance of these observations is not well defined. Here we show that NOD2-deficient mice exhibit a delayed but ultimately exacerbated ulcerative response and impaired bacterial clearance ..
  3. pmc Critical role of NOD2 in regulating the immune response to Staphylococcus aureus
    Hitesh S Deshmukh
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Infect Immun 77:1376-82. 2009
    b>NOD2 (the nucleotide-binding oligomerization domain containing protein 2) is known to be involved in host recognition of bacteria, although its role in the host response to Staphylococcus aureus infection is unknown...
  4. pmc Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    Immunity 34:75-84. 2011
    ..Here we report that the progression of EAE was dependent on the intracellular PGN sensors NOD1 and NOD2 and their common downstream adaptor molecule, receptor interacting protein 2 (RIP2; also known as RIPK2 and RICK)...
  5. ncbi Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes
    Thorsten Stroh
    Department of Medicine I, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 181:3620-7. 2008
    ..Thus, our results further strengthen the allocation of the mesenteric fat and especially of preadipocytes to the innate immune system...
  6. pmc NOD2 mediates inflammatory responses of primary murine glia to Streptococcus pneumoniae
    Xinjie Liu
    Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    Glia 58:839-47. 2010
    ..demonstrated that microglia and astrocytes constitutively express nucleotide-binding oligomerization domain-2 (NOD2), a member of the novel nucleotide-binding domain leucine-rich repeat region-containing family of proteins (NLR) ..
  7. pmc Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model
    Kaoru Geddes
    Department of Immunology, University of Toronto, Toronto, Ontario M6G 2T6, Canada
    Infect Immun 78:5107-15. 2010
    The pattern recognition molecules Nod1 and Nod2 play important roles in intestinal homeostasis; however, how these proteins impact on the development of inflammation during bacterial colitis has not been examined...
  8. pmc Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1739-45. 2009
    ..Notably, NOD2 is linked to eye inflammation because mutations in NOD2 cause a granulomatous type of uveitis called Blau syndrome...
  9. doi Immunohistochemical detection of NOD1 and NOD2 in the healthy murine and canine eye
    Emma Scurrell
    Department of Pathology and Infectious Diseases, The Royal Veterinary College, Hawkshead Lane, Herts, UK
    Vet Ophthalmol 12:269-75. 2009
    The innate immune system provides the immediate defense against pathogens. NOD1 and NOD2 proteins are intracytoplasmic signaling receptors of the innate immune system and recognize conserved microbial molecular structures...
  10. pmc Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    Amlan Biswas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14739-44. 2010
    Mutations in the NOD2 gene are strong genetic risk factors for ileal Crohn's disease. However, the mechanism by which these mutations predispose to intestinal inflammation remains a subject of controversy...
  11. pmc Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains
    Derek W Abbott
    Department of Pathology, Case Western Reserve University School of Medicine, Room 5123 Wolstein Research Building, Cleveland, OH 44106, and Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mol Cell Biol 27:6012-25. 2007
    ..inflammatory disorder in which this process may be faulty as the major Crohn's disease-associated protein, NOD2 (nucleotide oligomerization domain 2), regulates the formation of K63-linked polyubiquitin chains on the I kappa ..
  12. ncbi NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity
    Maziar Divangahi
    Department of Medicine, McGill University Health Centre, Montreal, Canada
    J Immunol 181:7157-65. 2008
    NOD2/CARD15 mediates innate immune responses to mycobacterial infection. However, its role in the regulation of adaptive immunity has remained unknown...
  13. pmc NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction
    Zhiqiong Yang
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Gastroenterology 133:1510-21. 2007
    Mutations in the CARD15 gene encoding NOD2 are susceptibility factors in Crohn's disease. We explored the mechanism of this susceptibility using mice that over express NOD2.
  14. pmc NOD2 contributes to the inflammatory responses of primary murine microglia and astrocytes to Staphylococcus aureus
    Xinjie Liu
    Department of Pediatrics, Qilu Hospital, Shandong University, 107, Wen Hua Xi Road, Jinan, Shandong, 250012, PR China
    Neurosci Lett 474:93-8. 2010
    We have recently demonstrated that microglia and astrocytes express nucleotide-binding oligomerization domain-2 (NOD2), a novel cytosolic pattern recognition receptor for bacterial motifs, and we have shown that this intracellular ..
  15. pmc The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes
    Jennifer C Miller
    Department of Pathology, University of Utah, Salt Lake City, Utah 84112, USA
    Infect Immun 78:3144-53. 2010
    ..burgdorferi-stimulated BMDMs occurs independently of the adapter TRIF and of the cytoplasmic sensor NOD2. In contrast, B...
  16. doi Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
    Ronan Kapetanovic
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    Microbes Infect 12:759-67. 2010
    ..In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed...
  17. ncbi Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts
    Shuhua Yang
    Department of Oral and Maxillofacial Surgery, Matsumoto Dental University, Shiojiri, Nagano, Japan
    J Immunol 175:1956-64. 2005
    ..Osteoblasts expressed mRNA of nucleotide-binding oligomerization domain 2 (Nod2), an intracellular sensor of MDP, in response to LPS, IL-1alpha, or TNF-alpha but not 1alpha,25(OH)2D3...
  18. ncbi NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2
    Yibin Yang
    Department of Pathology, Case Western University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 282:36223-9. 2007
    ..We find Rip2 required for Nod2-mediated NF-kappaB activation and to a lesser extent mitogen-activated protein kinase activation...
  19. pmc Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice
    Su Wol Chung
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:239-47. 2008
    ..These data advocate HO-1-derived CO as an important mediator of the host defense response to sepsis and suggest CO administration as a possible treatment for the disease...
  20. ncbi Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
    Noemi Marina-Garcia
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 180:4050-7. 2008
    Muramyl dipeptide (MDP), the microbial activator of nucleotide-binding oligomerization domain 2 (Nod2), induces NF-kappaB and MAPK activation, leading to the production of multiple anti-bacterial and proinflammatory molecules...
  21. pmc T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Immunol 10:1267-74. 2009
    b>Nod2 belongs to the nucleotide-binding oligomerization domain receptor (NLR) family of proteins, which function as intracellular pathogen sensors in innate immune cells...
  22. ncbi Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
    J Biol Chem 278:8869-72. 2003
    b>Nod2 activates the NF-kappaB pathway following intracellular stimulation by bacterial products...
  23. ncbi Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease
    Yasunori Ogura
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Genomics 81:369-77. 2003
    Genetic variation in human Nod2 has been associated with susceptibility to Crohn's disease. The mouse Nod2 locus is located at chromosome 8 and composed of 12 exons, 11 of which encode the Nod2 protein...
  24. ncbi Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene
    Y Iwanaga
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Inflamm Res 52:272-6. 2003
    Mutations in the human NOD2/CARD15 gene have been associated with Crohn's disease and Blau syndrome...
  25. pmc Role of nod2 in the response of macrophages to toll-like receptor agonists
    Anne Laure Pauleau
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 23:7531-9. 2003
    Nod2 (CARD15) is a macrophage-specific protein containing two CARD domains, a large nucleotide binding domain and leucine-rich repeats...
  26. ncbi NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Immunol 5:800-8. 2004
    The mechanism by which mutations in CARD15, which encodes nucleotide-binding oligomerization domain 2 (NOD2), cause Crohn disease is poorly understood...
  27. ncbi IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism
    Silvia Stockinger
    Max F Perutz Laboratories, University Department at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Austria
    J Immunol 173:7416-25. 2004
    ..Expression of Nod2, a candidate receptor for intracellular bacteria, increased during infection, but the protein was not required for ..
  28. ncbi The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO
    Derek W Abbott
    Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Curr Biol 14:2217-27. 2004
    ..The function of the Crohn's disease protein, NOD2, highlights the biphasic nature of the pathology of Crohn's disease...
  29. ncbi Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    Koichi S Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 307:731-4. 2005
    The gene encoding the Nod2 protein is frequently mutated in Crohn's disease (CD) patients, although the physiological function of Nod2 in the intestine remains elusive...
  30. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    Variants of NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP), increase susceptibility to Crohn's disease (CD)...
  31. pmc Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge
    Ian Marriott
    Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Infect Immun 73:2967-73. 2005
    ..we demonstrate that murine osteoblasts express the novel intracellular pattern recognition receptors Nod1 and Nod2. Levels of mRNA encoding Nod molecules and protein expression are significantly and differentially increased from ..
  32. ncbi NLRs join TLRs as innate sensors of pathogens
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Trends Immunol 26:447-54. 2005
    ....
  33. ncbi Functional expression of NOD2, a novel pattern recognition receptor for bacterial motifs, in primary murine astrocytes
    David Sterka
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 53:322-30. 2006
    ..We show that isolated cultures of murine astrocytes constitutively express robust levels of NOD2, a molecule that can recognize a minimal peptidoglycan motif...
  34. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  35. ncbi IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2
    Sabine Tötemeyer
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    J Immunol 176:4804-10. 2006
    ..This study also shows that the effect of IFN-gamma in restoring inflammatory responses to gram-negative bacteria or bacterial products in mice with defective TLR4 signaling is likely to be due to a response to peptidoglycan, not LPS...
  36. ncbi Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC, Room 5W3940, 10 Center Drive, Bethesda, Maryland 20892, USA
    Immunity 25:473-85. 2006
    ..conditions leading to the development of colitis in mice with nucleotide binding oligomerization domain 2 (NOD2) deficiency, a susceptibility factor in Crohn's disease...
  37. ncbi RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs
    Jong Hwan Park
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 178:2380-6. 2007
    RICK is a kinase that has been implicated in Nod1 and Nod2 signaling. In addition, RICK has been proposed to mediate TLR signaling in that its absence confers reduced responses to certain bacterial products such as LPS...
  38. pmc Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system
    Anat A Herskovits
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS Pathog 3:e51. 2007
    ..bacterial ligands in the phago-lysosome and was largely dependent on nucleotide-binding oligomerization domain 2 (NOD2), a cytosolic receptor known to respond to bacterial peptidoglycan fragments...
  39. ncbi MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3
    Qilin Pan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Leukoc Biol 82:177-83. 2007
    ..b>Nod2 also plays a role in some autoinflammatory diseases...
  40. ncbi Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    Thirumala Devi Kanneganti
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Immunity 26:433-43. 2007
    ..These results provide evidence for cytosolic delivery and sensing of bacterial molecules as a unifying model for caspase-1 activation and position pannexin-1 as a mechanistic link between bacterial stimuli and the cryopyrin inflammasome...
  41. pmc CARD15/NOD2 is required for Peyer's patches homeostasis in mice
    Frederick Barreau
    U843, INSERM, Paris, France UMR S843, Universite Paris Diderot, Paris, France
    PLoS ONE 2:e523. 2007
    b>CARD15/NOD2 mutations are associated with susceptibility to Crohn's Disease (CD) and Graft Versus Host Disease (GVHD)...
  42. ncbi Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2
    Gerben Ferwerda
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 82:1011-8. 2007
    ..mutations in the intracellular pathogen recognition receptor (PRR) nucleotide-binding oligomerization domain 2 (NOD2). The aim of this study is to investigate the PRR involved in the recognition of M. paratuberculosis...
  43. ncbi Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway
    Catherine Werts
    Unité de Recherche Réponses Précoces aux Parasites et Immunopathologie, Institut Pasteur, Paris, France
    Eur J Immunol 37:2499-508. 2007
    The Nod-like receptor proteins Nod1 and Nod2 participate in innate immune responses against bacteria through intracellular detection of peptidoglycan, a component of bacterial cell wall...
  44. pmc Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis
    Sheetal Gandotra
    Department of Microbiology and Immunology, Weill Cornell Medical College, Box 62, 1300 York Avenue, New York, NY 10021, USA
    Infect Immun 75:5127-34. 2007
    ..b>NOD2 has recently been shown to be important for host cell cytokine responses to Mycobacterium tuberculosis, to ..
  45. ncbi Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 38:184-91. 2008
    ..Mutations in the nucleotide oligomerization domain 2 (NOD2) gene are associated with an increased risk of Crohn's disease...
  46. doi Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3
    Johann Röhrl
    Institute of Immunology University of Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 283:5414-9. 2008
    ..expression of mBD14 seems to be regulated by activation of the intracellular pattern recognition receptor NOD2/CARD15 as revealed by reporter gene analysis...
  47. pmc Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:545-59. 2008
    The mechanisms underlying the susceptibility of individuals with caspase recruitment domain 15 (CARD15) mutations and corresponding abnormalities of nucleotide-binding oligomerization domain 2 (NOD2) protein to Crohn disease are still ..
  48. doi NOD2: a potential target for regulating liver injury
    Mathilde Body-Malapel
    INSERM U795, Lille, France
    Lab Invest 88:318-27. 2008
    The recent discovery of bacterial receptors such as NOD2 that contribute to crosstalk between innate and adaptive immune systems in the digestive tract constitutes an important challenge in our understanding of liver injury mechanisms...
  49. doi The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    Yun Gi Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 28:246-57. 2008
    The cytosolic sensors Nod1 and Nod2 and Toll-like receptors (TLRs) activate defense signaling pathways in response to microbial stimuli...
  50. pmc NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 49:1518-24. 2008
    ..Specific mutations in the human NOD2 gene cause Blau syndrome, an autosomal dominant form of uveitis, arthritis, and dermatitis...
  51. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    b>NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that was suggested to promote secretion of the proinflammatory cytokine IL-1beta...
  52. pmc NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 57:414-23. 2009
    ..demonstrated that microglia and astrocytes constitutively express nucleotide-binding oligomerization domain-2 (NOD2), a member of the novel nucleotide-binding domain leucine-rich repeat region containing a family of proteins (NLR) ..
  53. doi Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    Djahida Bouskra
    Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961
    Nature 456:507-10. 2008
    ..Our results demonstrate that intestinal bacterial commensals and the immune system communicate through an innate detection system to generate adaptive lymphoid tissues and maintain intestinal homeostasis...
  54. ncbi Nod2-dependent Th2 polarization of antigen-specific immunity
    Joao Gamelas Magalhaes
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 181:7925-35. 2008
    ..Here, we examined the unfolding of the adaptive immune response induced by Nod2 in vivo upon activation by its specific ligand, muramyl dipeptide, a component of peptidoglycan...
  55. pmc Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    Shipra Vaishnava
    The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:20858-63. 2008
    ..Our findings establish that gut epithelia actively sense enteric bacteria and play an essential role in maintaining host-microbial homeostasis at the mucosal interface...
  56. pmc Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis
    H L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97219, USA
    J Leukoc Biol 85:711-8. 2009
    In addition to its role in innate immunity, nucleotide oligomerization domain 2 (NOD2) has been shown to play a suppressive role in models of colitis...
  57. pmc PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation
    Sukumar Saha
    Indiana University School of Medicine Northwest, Gary, IN 46408, USA
    Cell Host Microbe 5:137-50. 2009
    ..We demonstrate that PGLYRP-2 and Nod2 are both required for arthritis in this model...
  58. pmc Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide
    Francois Coulombe
    Department of Medicine, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    J Exp Med 206:1709-16. 2009
    Peptidoglycan-derived muramyl dipeptide (MDP) activates innate immunity via the host sensor NOD2. Although MDP is N-acetylated in most bacteria, mycobacteria and related Actinomycetes convert their MDP to an N-glycolylated form through ..
  59. pmc Nod2 is required for the regulation of commensal microbiota in the intestine
    Tanja Petnicki-Ocwieja
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:15813-8. 2009
    Mutations in the Nod2 gene are among the strongest genetic risk factors in the pathogenesis of ileal Crohn's disease, but the exact contributions of Nod2 to intestinal mucosal homeostasis are not understood...
  60. doi Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    Leonardo H Travassos
    Department of Immunology, University of Toronto, Toronto, Canada
    Nat Immunol 11:55-62. 2010
    ..Here we demonstrated that the intracellular sensors Nod1 and Nod2 are critical for the autophagic response to invasive bacteria...
  61. pmc Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
    Thomas B Clarke
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 16:228-31. 2010
    ..meso-diaminopimelic acid (mesoDAP)-containing peptidoglycan found predominantly in Gram-negative bacteria), but not Nod2 (which detects peptidoglycan found in Gram-positive and Gram-negative bacteria) or Toll-like receptor 4 (Tlr4, ..
  62. doi The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila
    Mariana S Frutuoso
    Department of Cell Biology, University of Sao Paulo, School of Medicine of Ribeirao Preto, FMRP USP, Ribeirao Preto, SP 14049 900, Brazil
    Microbes Infect 12:819-27. 2010
    ..By using mice deficient for Nod1, Nod2, and Rip2, we found that these receptors accounted for NE recruitment to the lungs of infected mice...
  63. doi Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells
    Cristina Conforti-Andreoni
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Biopolis, Singapore
    J Leukoc Biol 88:1207-16. 2010
    ..study, we employed microarrays to investigate in DCs the regulation of gene transcription mediated by activation of NOD2 and NLRP3 pathways using MDP and MSU...
  64. pmc Staphylococcal peptidoglycan co-localizes with Nod2 and TLR2 and activates innate immune response via both receptors in primary murine keratinocytes
    Maria Anna Müller-Anstett
    Microbial Genetics, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e13153. 2010
    In mammalian host cells staphylococcal peptidoglycan (PGN) is recognized by Nod2. Whether PGN is also recognized by TLR2 is disputed...
  65. pmc NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila
    William R Berrington
    University of Washington School of Medicine, Seattle, WA 98195 6523, USA
    Eur J Immunol 40:3519-27. 2010
    The role of nucleotide-binding oligomerization domain-1 (NOD1) and nucleotide-binding oligomerization domain-2 (NOD2), cytoplasmic receptors which detect bacterial cell wall molecules, in pulmonary innate immune responses is poorly ..
  66. pmc Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses
    Justine T Tigno-Aranjuez
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genes Dev 24:2666-77. 2010
    Upon intracellular bacterial exposure, the Crohn's disease and sarcoidosis susceptibility protein NOD2 (nucleotide oligomerization domain protein 2) binds to the protein kinase RIP2 (receptor-interacting protein 2) to coordinate NF-κB (..
  67. doi Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages
    Wen Hsiang Tsai
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Microbiol 13:717-30. 2011
    b>NOD2 of the NLRs and TLR4 of the TLRs are major pattern-recognition receptors, which sense different microbial pathogens and have important roles in innate immunity...
  68. pmc Muramyl dipeptide induces Th17 polarization through activation of endothelial cells
    Michela Manni
    Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA
    J Immunol 186:3356-63. 2011
    ..These results are important for the understanding of Th17-related disorders of the skin such as psoriasis...
  69. pmc The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes
    Yun Gi Kim
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 34:769-80. 2011
    The intracellular sensor Nod2 is activated in response to bacteria, and the impairment of this response is linked to Crohn's disease. However, the function of Nod2 in host defense remains poorly understood...
  70. pmc Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections
    Yun Gi Kim
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Host Microbe 9:496-507. 2011
    ..show that the TLR3/MDA5 agonist poly I:C or viral infection dramatically augments signaling via the NLRs Nod1 and Nod2 and enhances the production of proinflammatory cytokines...
  71. pmc NOD1 activators link innate immunity to insulin resistance
    Jonathan D Schertzer
    Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Diabetes 60:2206-15. 2011
    ....
  72. pmc Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice
    Kimberly M Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    J Clin Invest 121:3666-76. 2011
    ..in mice lacking digestion of peptidoglycan by lysozyme (LysM) and cytosolic sensing of the products of digestion by Nod2. Ex vivo macrophages produced CCL2 following bacterial uptake, digestion by LysM, and sensing of peptidoglycan by ..
  73. pmc Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation
    Joao G Magalhaes
    Department of Immunology, University of Toronto, Toronto, ON, Canada M5A 2N4
    Proc Natl Acad Sci U S A 108:14896-901. 2011
    ..immunization with antigen plus either nucleotide-binding oligomerization domain-containing proteins 1 (Nod1) or 2 (Nod2) agonists drives Th2 induction to understand how these pattern-recognition receptors mediate the development of ..
  74. pmc Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii
    Bráulia C Caetano
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Eur J Immunol 41:3627-31. 2011
    b>Nod2 belongs to the nucleotide-binding domain leucine-rich repeat family of proteins and senses bacterial cell wall components to initiate innate immune responses against various pathogens...
  75. pmc NOD2 signaling contributes to host defense in the lungs against Escherichia coli infection
    Balamayooran Theivanthiran
    Laboratory of Lung Biology, Department of Pathobiological Sciences and Center for Experimental Infectious Disease Research, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 80:2558-69. 2012
    ..that RIP2 is important for host defense in the lungs against Escherichia coli, the individual roles of NOD1 and NOD2 in pulmonary defense have not been addressed...
  76. doi Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses
    Ida H Hiemstra
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    Mol Immunol 52:264-72. 2012
    ..shRNA knock-down studies showed that MDP recognition by Nod2 mediated the enhancement of TLR responses...
  77. pmc NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
    Aurélie Couturier-Maillard
    University Lille Nord de France, Lille, France
    J Clin Invest 123:700-11. 2013
    ..Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice...
  78. pmc TLR2 and Nod2 mediate resistance or susceptibility to fatal intracellular Ehrlichia infection in murine models of ehrlichiosis
    Partho Chattoraj
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e58514. 2013
    ..cytokines and chemokines, which was associated with increased expression levels of Toll-like receptor-2 (TLR2), Nod2, MyD88, nuclear factor-kappa B (NF-kB), Caspase 4, NLRP1, NLRP12, Pycard, and IL-1β, suggesting enhanced TLR ..
  79. doi Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection
    Thirumahal Selvanantham
    Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Immunol 191:5646-54. 2013
    ..We show that the cytosolic peptidoglycan-sensing receptors Nod1 and Nod2 are necessary for optimal IFN-γ production by iNKT cells, as well as NK cells...
  80. pmc Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice
    Ulrich Meinzer
    INSERM, U843, Universite Paris 7, Hopital Robert Debre, Paris, France
    PLoS ONE 3:e2769. 2008
    Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo...
  81. pmc Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection
    Lionel Le Bourhis
    University of Toronto, Department of Immunology, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 77:4480-6. 2009
    ..Nod1 and Nod2 are intracellular PRMs that detect peptidoglycan motifs from the cell walls of bacteria once they gain access to ..
  82. doi Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches
    Frederick Barreau
    INSERM, U843, Paris, France
    Gut 59:207-17. 2010
    Nucleotide oligomerisation domain 2 (NOD2) mutations are associated with susceptibility to Crohn's disease and graft-versus-host disease, two human disorders related with dysfunctions of Peyer's patches (PPs)...
  83. pmc Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling
    H L Rosenzweig
    Department of Ophthalmology, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Mail Stop L467 IM, Portland, OR 97239, USA
    J Leukoc Biol 84:529-36. 2008
    Nucleotide-binding and oligomerization domain 2 (NOD2) belongs to the emerging Nod-like receptor (NLR) family considered important in innate immunity...
  84. pmc A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling
    Justine T Tigno-Aranjuez
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 33:146-58. 2013
    Dysregulation of NOD2 signaling is implicated in the pathology of various inflammatory diseases, including Crohn's disease, asthma, and sarcoidosis, making signaling proteins downstream of NOD2 potential therapeutic targets...
  85. ncbi The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    Yen Michael S Hsu
    Department of Molecular and Cellular Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Immunol 8:198-205. 2007
    ..In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK...
  86. pmc TAK1 is a central mediator of NOD2 signaling in epidermal cells
    Jae Young Kim
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Biol Chem 283:137-44. 2008
    ..is a peptidoglycan moiety derived from commensal and pathogenic bacteria, and a ligand of its intracellular sensor NOD2. Mutations in NOD2 are highly associated with Crohn disease, which is characterized by dysregulated inflammation in ..
  87. pmc Toll-like receptor 2 and nucleotide-binding oligomerization domain-2 play divergent roles in the recognition of gut-derived lactobacilli and bifidobacteria in dendritic cells
    Louise Hjerrild Zeuthen
    BioCentrum DTU, Nutritional Immunology Group, Center for Biological Sequence Analysis, Technical University of Denmark, Kgs Lyngby, Denmark
    Immunology 124:489-502. 2008
    ..we reveal divergent roles played by Toll-like receptor-2 (TLR2) and nucleotide-binding oligomerization domain-2 (NOD2) in dendritic cell (DC) recognition of LAB...
  88. pmc Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival
    Sheena M Cruickshank
    the Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    World J Gastroenterol 14:5834-41. 2008
    To investigate the function of NOD2 in colonic epithelial cells (CEC).
  89. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  90. pmc The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Pathog 5:e1000379. 2009
    ..Both Nod1(-/-) and Nod2(-/-) mice also showed delayed bacterial clearance, suggesting that C...
  91. pmc Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure
    Crystal L Loving
    Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic and Allergenic Products, CBER, FDA, Bethesda, Maryland, USA
    Infect Immun 77:4529-37. 2009
    ..Nod1 and Nod2, members of the NLR family, are capable of detecting bacterial peptidoglycan motifs in the host cytosol for ..
  92. doi Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo
    Jumpei Asano
    Department of Immunology, Akita University Graduate School of Medicine, Akita, Japan
    J Immunol 184:736-45. 2010
    ..In this study, we demonstrate that injecting ligands for Nod1 and Nod2 along with Ag into wild-type mice significantly enhanced the cross-priming of Ag-specific CD8+ T cells by CD8alpha+ ..
  93. pmc Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan
    Holly L Rosenzweig
    Oregon Health and Science University, Portland, OR 97239, USA
    Arthritis Rheum 62:1051-9. 2010
    Blau syndrome is an autoinflammatory disease resulting from mutations in the NOD2 gene, wherein granulomatous arthritis, uveitis, and dermatitis develop...
  94. doi Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling
    Claudia Toma
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa
    J Immunol 184:5287-97. 2010
    ..Our results identify the NLRP3 inflammasome as a sensor of Vibrio infections through the action of bacterial cytotoxins and differential activation of innate signaling pathways acting upstream of NF-kappaB...
  95. pmc Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium
    Ward M Richardson
    Division of Pediatric Surgery, Department of Surgery, Children s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 139:904-17, 917.e1-6. 2010
    ..Nucleotide-binding oligomerization domain-2 (NOD2) is an immune receptor that regulates other branches of the immune system, although its effects on TLR4 in ..
  96. pmc A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses
    Jill M Marinis
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 286:1938-50. 2011
    The Crohn's disease and early onset sarcoidosis susceptibility protein, NOD2, coordinates innate immune signaling pathways...
  97. pmc Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation
    Kushagra Bansal
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 286:5823-35. 2011
    Intracellular pathogen sensor, NOD2, has been implicated in regulation of wide range of anti-inflammatory responses critical during development of a diverse array of inflammatory diseases; however, underlying molecular details are still ..
  98. pmc Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling
    Jinghua Wang
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:10225-32. 2011
    ..pneumoniae or stimulated with Toll-like receptor (TLR) and Nod2 ligands. We found that a significant increase in IL-23 protein production was observed in S...
  99. doi Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen
    Mizuho Hasegawa
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 186:4872-80. 2011
    ..Nod1(-/-), but not Nod2(-/-), mice exhibited increased lethality in response to C...
  100. pmc Organic dust augments nucleotide-binding oligomerization domain expression via an NF-{kappa}B pathway to negatively regulate inflammatory responses
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division Dept of Medicine, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 301:L296-306. 2011
    Nucleotide-binding oligomerization domain 2 (NOD2) is involved in innate immune responses to peptidoglycan degradation products...
  101. pmc The PepT1-NOD2 signaling pathway aggravates induced colitis in mice
    Guillaume Dalmasso
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 141:1334-45. 2011
    ..the contribution of PepT1 to intestinal inflammation in mouse models of colitis and the involvement of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway in the pathogenic activity of colonic epithelial hPepT1.

Research Grants4

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Mutations in Nod2 result in Blau syndrome and predispose to Crohn's disease, both of which are autoimmune diseases characterized by uveitis...
  2. Bacterial infection induces cytokine production
    Ian Marriott; Fiscal Year: 2003
    ..abstract_text> ..
  3. Osteoblast-derived inflammatory mediators in infection
    Ian Marriott; Fiscal Year: 2004
    ..aureus by the production of this pivotal inflammatory molecule, thereby expanding the recognized role of these cells to include being key components in host responses during bone infection. ..
  4. RIP2 kinase's function in Innate Immunity
    Derek Abbott; Fiscal Year: 2007
    ..This grant application aims to define the preferred peptide phosphorylation sites of RIP2, to map the phosphorylation site of TRAF6 and to identify the physiologic significance of RIP2's phosphorylation of TRAF6. ..