Nlrp3

Summary

Gene Symbol: Nlrp3
Description: NLR family, pyrin domain containing 3
Alias: AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1, NACHT, LRR and PYD domains-containing protein 3, NACHT/LRR/pyrin domain-containing protein 3, PYRIN-containing APAF1-like protein 1, cold autoinflammatory syndrome 1 homolog, cold autoinflammatory syndrome 1 protein homolog, cryopyrin, mast cell maturation inducible protein 1, mast cell maturation-associated-inducible protein 1
Species: mouse

Top Publications

  1. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  2. pmc Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Science 320:674-7. 2008
  3. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
  4. pmc Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
  5. doi Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 11:136-40. 2010
  6. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
  7. pmc The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 30:556-65. 2009
  8. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
  9. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
  10. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..ASC also interacts with the adaptor cryopyrin (also known as NALP3 or CIAS1)...
  2. pmc Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Science 320:674-7. 2008
    ..Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion...
  3. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
    ..Here we show that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1beta and IL-18...
  4. pmc Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
    ..that aluminium adjuvants activate an intracellular innate immune response system called the Nalp3 (also known as cryopyrin, CIAS1 or NLRP3) inflammasome...
  5. doi Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 11:136-40. 2010
    The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome activity is associated with several inflammatory diseases, yet little is known about the signaling pathways that lead to its activation...
  6. pmc Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:897-904. 2010
    ..polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β...
  7. pmc The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 30:556-65. 2009
    ..As a test of the physiologic role of the NLR molecule NLRP3 during RNA viral infection, we explored the in vivo role of NLRP3 inflammasome components during influenza virus ..
  8. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..Here, we show that nano-TiO(2) and nano-SiO(2), but not nano-ZnO, activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome, leading to IL-1β release and in addition, induce the regulated release of IL-1α...
  9. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..response and subsequent development of pulmonary fibrosis after inhalation of silica is dependent on the Nalp3 inflammasome...
  10. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..Although NLRP3 was required for inflammasome activation in certain cell types, CD4 and CD8 T cell responses, as well as mucosal ..
  11. pmc The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen 6525 GA, The Netherlands
    Cell Metab 12:593-605. 2010
    ..In addition, differentiation of preadipocytes isolated from caspase-1(-/-) or NLRP3(-/-) mice resulted in more metabolically active fat cells...
  12. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..Activation of caspase-1 in macrophages occurred independently of Nalp3 and proteasome activity, suggesting that a previously uncharacterized mechanism for caspase-1 activation through ..
  13. doi The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18
    SUSHMITA JHA
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Neurosci 30:15811-20. 2010
    ..Nucleotide-binding domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) is a key component of the inflammasome complex, which also includes ASC (apoptotic speck-containing protein with ..
  14. doi Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity
    Stephen J Lalor
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Immunol 186:5738-48. 2011
    ..Conversely, gain-of-function mutations in the NLRP3 inflammasome complex are associated with enhanced IL-1β and IL-18 production and Th17 responses...
  15. pmc Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
    Antonia Fettelschoss
    Department of Dermatology, Zurich University Hospital, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:18055-60. 2011
    ..We further demonstrate that IL-1β directly binds IL-1α, thus identifying IL-1β as a shuttle for another proinflammatory cytokine. These results have direct impact on selective treatment modalities of inflammatory diseases...
  16. pmc Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA, USA
    J Exp Med 207:1745-55. 2010
    ..However, the NLRs that respond to microbial pathogens in vivo are poorly defined. We show that the NLRs NLRP3 and NLRC4 both activate caspase-1 in response to Salmonella typhimurium...
  17. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
    ..This paper addressed the role of NLRP3 (NALP3), its adaptor protein PYCARD (ASC), and caspase-1 during infection with Mycobacterium tuberculosis (Mtb)...
  18. pmc The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
    Jayant V Rajan
    Institute for Systems Biology, 1441 34th Avenue N, Seattle, WA 98104, USA
    J Virol 85:4167-72. 2011
    ..Several different inflammasome complexes have been identified, but the NLRP3 inflammasome is particularly notable because of its central role in diseases of inflammation...
  19. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    ..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion...
  20. ncbi Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    Fayyaz S Sutterwala
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:317-27. 2006
    Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome...
  21. pmc NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways
    Stephen B Willingham
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 183:2008-15. 2009
    ..The regulation of these responses is studied in the context of the inflammasome components NLRP3 and ASC, which are important for caspase-1 activation and IL-1beta release...
  22. pmc Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    Bo Hu
    Department of Immunobiology, Section of Comparative Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:21635-40. 2010
    ..We suggest a model in which the NLRC4 inflammasome is central to colonic inflammation-induced tumor formation through regulation of epithelial cell response to injury...
  23. pmc Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
    Rendong Fang
    Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Immunol 187:4890-9. 2011
    ..receptors such as nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2), is essentially required for the induction of caspase-1 activation by S...
  24. doi The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils
    Arun K Mankan
    Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Eur J Immunol 42:710-5. 2012
    ..Here, we identify the expression of the components of the NLRP3 inflammasome complex in neutrophils and show that the NLRP3 inflammasome pathway is indeed operational in ..
  25. doi Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    James E Vince
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:215-27. 2012
    ..After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1β that was mediated not only by the NLRP3-caspase-1 inflammasome, but also by caspase-8 in a caspase-1-independent manner...
  26. pmc Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
    Brian D Gulbransen
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:600-4. 2012
    ..Targeting Panx1 represents a new neuroprotective strategy to ameliorate the progression of IBD-associated dysmotility...
  27. pmc Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    Sarah E Warren
    Department of Immunology, University of Washington, Seattle WA 98195, USA
    J Immunol 180:7558-64. 2008
    ..the cytosolic compartment induces caspase 1 activation through multiple Nod-like receptors, including Ipaf and Nalp3. Flagellin expression by cytosolic L. monocytogenes was detected through Ipaf in a dose-dependent manner...
  28. pmc Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
    Susannah D Brydges
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:875-87. 2009
    ..Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS)...
  29. ncbi Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 37:3030-9. 2007
    ..These results provide new insight into the interaction of P. aeruginosa with host macrophages and suggest that distinct regions of flagellin are sensed by Ipaf and TLR5...
  30. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
    ..Finally, AIM2-deficient mice displayed increased susceptibility to F. tularensis infection compared with wild-type mice. Their increased bacterial burden in vivo confirmed that AIM2 is essential for an effective innate immune response...
  31. doi Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome
    Ramanjaneyulu Allam
    Medizinische Poliklinik, Universitat Munchen, Munich, Germany
    J Immunol 186:2714-8. 2011
    ..All four antibiotics required the NLRP3 inflammasome, the adaptor ASC, and caspase-1 activation to secrete IL-1β, a process that depended on potassium ..
  32. pmc Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e21477. 2011
    ..In vitro investigation reveals that CP-induced IL-1β secretion by macrophages requires TLR2/MyD88 and NLRP3/ASC/Caspase-1 signaling...
  33. pmc P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1
    Yan Qu
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 182:5052-62. 2009
    ..regulatory proteins, ASC (apoptosis-associated speck-like protein containing a caspase-recruitment domain) and NLRP3 (NLR family, pyrin domain containing 3), which are essential for caspase-1 activation, were also required for the ..
  34. pmc A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome
    Raúl Muñoz-Planillo
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 183:3942-8. 2009
    The mechanism by which bacterial pathogens activate caspase-1 via Nlrp3 remains poorly understood...
  35. doi Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production
    Yu Hu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, China
    J Immunol 185:7699-705. 2010
    The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is critical for caspase-1 activation and the proteolytic processing of pro-IL-1β. However, the mechanism that regulates NLRP3 inflammasome activation remains unclear...
  36. pmc Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice
    Jae Jin Chae
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:755-68. 2011
    ..was completely ablated by crossing with IL-1 receptor-deficient or adaptor molecule ASC-deficient mice, but not NLRP3-deficient mice...
  37. pmc NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
    Chengcheng Jin
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:14867-72. 2011
    ..shape can stimulate robust secretion of proinflammatory cytokines IL-1β and IL-18 from murine macrophages in a NLRP3 inflammasome-dependent manner...
  38. pmc Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages
    Nadia M Luheshi
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 42:716-25. 2012
    ..Endogenous danger-associated molecular patterns (DAMPs) released from necrotic cells activate caspase-1 through an NLRP3-inflammasome...
  39. pmc Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection
    Uma M Nagarajan
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Immunol 188:2866-75. 2012
    ..muridarum. To investigate the role of inflammasome components during in vivo genital infection, mice lacking NLRP3, NLRC4, and ASC were tested and found to display no reduction in oviduct pathology compared with control mice...
  40. pmc Critical role for calcium mobilization in activation of the NLRP3 inflammasome
    Tomohiko Murakami
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:11282-7. 2012
    The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome mediates production of inflammatory mediators, such as IL-1β and IL-18, and as such is implicated in a variety of ..
  41. pmc Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
    Maria Lara-Tejero
    Section of Microbial Pathogenesis, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Exp Med 203:1407-12. 2006
    ..We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection...
  42. pmc Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
    Marina Tiemi Shio
    Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000559. 2009
    ..we showed that Hz-induced IL-1beta and inflammation are dependent on NOD-like receptor containing pyrin domain 3 (NLRP3), ASC and caspase-1, but not NLRC4 (NLR containing CARD domain)...
  43. pmc A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
    Ying Zheng
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 7:e1002026. 2011
    ..K+ efflux, NLRP3 and ASC were important for secretion of IL-1β in response to Y...
  44. ncbi ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    ..phagocytophilum. The NLR family member IPAF/NLRC4, but not NALP3/NLRP3, was partially required for IFN-gamma production in response to A. phagocytophilum...
  45. doi Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3
    Karolin Meixenberger
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 184:922-30. 2010
    Different NOD-like receptors, including NLRP1, NLRP3, and NLRC4, as well as the recently identified HIN-200 protein, AIM2, form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta...
  46. pmc Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion
    Takahiro Shimada
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cell Host Microbe 7:38-49. 2010
    ..cell wall component peptidoglycan (PGN) must be particulate and internalized via phagocytosis to activate NLRP3 inflammasomes and IL-1beta secretion. In the context of S...
  47. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
    ..TLR2 was required for induction of pro-IL-1beta, whereas the NLRP3/ASC was required for caspase-1 activation and pro-IL-1beta cleavage to produce mature IL-1beta...
  48. pmc Activation of the NLRP3 inflammasome by intracellular poly I:C
    Jayant V Rajan
    Institute for Systems Biology, Seattle, WA 98103, USA
    FEBS Lett 584:4627-32. 2010
    ..We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification...
  49. pmc The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
    Geun Shik Lee
    Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 492:123-7. 2012
    Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS)...
  50. ncbi Induction of PYPAF1 during in vitro maturation of mouse mast cells
    Rei Kikuchi-Yanoshita
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555
    J Biochem 134:699-709. 2003
    ..MMIG-1 shows >85% sequence similarity to human cryopyrin/PYPAF1, a causal gene for familial cold urticaria and Muckle-Wells syndrome...
  51. pmc Structural, expression, and evolutionary analysis of mouse CIAS1
    Justin P Anderson
    Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Gene 338:25-34. 2004
    ..CIAS1 codes for the protein Cryopyrin, which appears to play a role in innate immune function by regulating the production of proinflammatory ..
  52. ncbi Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    Thirumala Devi Kanneganti
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Nature 440:233-6. 2006
    ..b>Cryopyrin (also called Nalp3), the product of CIAS1, is a member of the NOD-LRR protein family that has been linked to the ..
  53. ncbi Caspase-1 inflammasomes in infection and inflammation
    Mohamed Lamkanfi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Leukoc Biol 82:220-5. 2007
    ..b>Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA,..
  54. ncbi Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
    Noemi Marina-Garcia
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 180:4050-7. 2008
    ..Caspase-1 activation induced by MDP and ATP required pannexin-1 and Cryopyrin but was independent of Nod2...
  55. ncbi Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Immunol 181:3755-9. 2008
    ..the release of IL-1beta from macrophages and dendritic cells and that this is abrogated in cells lacking various NALP3 inflammasome components...
  56. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Toll-like receptor 9 (TLR9) and NLRP3 inflammasome were shown to be the principal specific sensors of viral double-stranded DNA...
  57. doi Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
    Hendrik Poeck
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 11:63-9. 2010
    ..inflammasome activation by a mechanism independent of MAVS, CARD9 and the Nod-like receptor protein NLRP3. Our results identify the CARD9-Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory ..
  58. ncbi Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
    Amal Amer
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:35217-23. 2006
    ..These results reveal that Ipaf restricts Legionella replication through the regulation of phagosome maturation, providing a novel function for NLR proteins in host defense against an intracellular bacterium...
  59. ncbi Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    Thirumala Devi Kanneganti
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:36560-8. 2006
    ..to caspase-1 activation that is induced by double-stranded RNA (dsRNA) and viral infection that is mediated by Cryopyrin/Nalp3...
  60. ncbi MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3
    Qilin Pan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Leukoc Biol 82:177-83. 2007
    ..Nod2 also plays a role in some autoinflammatory diseases. Cold-induced autoinflammatory syndrome 1 (CIAS1)/NACHT domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NALP3) has been suggested to be ..
  61. ncbi Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    Thirumala Devi Kanneganti
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Immunity 26:433-43. 2007
    b>Cryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine triphosphate (ATP). However, the events linking bacterial products and ATP to cryopyrin remain unclear...
  62. ncbi Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    V Petrilli
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, Center of Immunology Lausanne, Epalinges 1066, Switzerland
    Cell Death Differ 14:1583-9. 2007
    ..The inflammasomes harboring the NLR members NALP1, NALP3 and IPAF have been best characterized...
  63. doi The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    Daniel A Muruve
    Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nature 452:103-7. 2008
    ..that internalized adenoviral DNA induces maturation of pro-interleukin-1beta in macrophages, which is dependent on NALP3 and ASC, components of the innate cytosolic molecular complex termed the inflammasome...
  64. pmc Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    Hanfen Li
    Department Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 181:17-21. 2008
    ..IL-18, and IL-33 is mediated by the NLR (nucleotide-binding domain leucine-rich repeat-containing) protein NLRP3 and its adaptor ASC, but not by NLRC4...
  65. pmc The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    Annett Halle
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:857-65. 2008
    ..Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in the release of IL-1 beta...
  66. pmc The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 38:2085-9. 2008
    ..of IL-1beta triggered by alum is abrogated in macrophages deficient in the NLR family, pyrin domain containing 3 (Nlrp3) protein and the apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) but not the ..
  67. doi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
    ..Nlrp3 (also known as NALP3) was identified as the critical NOD-like receptor family member that transduces the fungal recognition signal to ..
  68. pmc The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 30:566-75. 2009
    ..Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome resulting in caspase-1 activation...
  69. pmc Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
    Yuumi Nakamura
    Department of Dermatology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    J Exp Med 206:1037-46. 2009
    Urticarial rash observed in cryopyrin-associated periodic syndrome (CAPS) caused by nucleotide-binding oligomerization domain-leucine-rich repeats containing pyrin domain 3 (NLRP3) mutations is effectively suppressed by anti-interleukin (..
  70. pmc Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
    Joseph A Duncan
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 182:6460-9. 2009
    ..We demonstrate that NLRP3 (cryopyrin, NALP3) is the primary NLR required for IL-1beta/IL-18 secretion in response to N. gonorrhoeae in monocytes...
  71. pmc A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
    Guangxun Meng
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:860-74. 2009
    Missense mutations of the gene encoding NLRP3 are associated with autoinflammatory disorders characterized with excessive production of interleukin-1beta (IL-1beta)...
  72. pmc Malarial hemozoin is a Nalp3 inflammasome activating danger signal
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 4:e6510. 2009
    ..include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome...
  73. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
    ..In this study we show that infection with Candida albicans is sensed by the Nlrp3 inflammasome, resulting in the subsequent release of IL-1beta. The ability of C...
  74. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
    ..CD4 and CD8 T cell responses, Ab responses and the Th2 bias were also not impacted by the absence of caspase-1 or NLRP3. These data suggest that activation of the inflammasome and the type 2 innate response orchestrated by macrophages ..
  75. doi Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    Francois Ghiringhelli
    Institut National de la Sante et de la Recherche Medicale, U805, Villejuif, France
    Nat Med 15:1170-8. 2009
    ..P2X(7) purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1beta (IL-..
  76. pmc Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid
    Jason W Griffith
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA
    J Immunol 183:5208-20. 2009
    ..components ICE (IL-1beta-converting enzyme), ASC (apoptosis-associated, speck-like protein containing CARD), and NALP3. Of note, inflammasome activation by sHz is reduced by allopurinol, which is an inhibitor of uric acid synthesis...
  77. pmc Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells
    Robin R Craven
    Department of Medicine Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e7446. 2009
    ..the Nucleotide-binding domain and leucine-rich repeat containing gene family, pyrin domain containing 3 protein (NLRP3)-inflammasome, a host inflammatory signaling complex involved in responses to pathogens and endogenous danger ..
  78. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
    ..Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome resulting in the subsequent release of the proinflammatory cytokine IL-1beta...
  79. pmc Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome
    Thornik Reimer
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 40:764-9. 2010
    ..Using the P. berghei ANKA infection model of mice, we investigated a potential involvement of Nlrp3 and the inflammasome in the pathogenesis of cerebral malaria...
  80. doi Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan
    Himanshu Kumar
    Laboratory of Host Defense
    J Immunol 183:8061-7. 2009
    ..promoted the production of the proinflammatory cytokine IL-1beta by dendritic cells and macrophages through the NLRP3 inflammasome...
  81. pmc The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 32:379-91. 2010
    Decreased expression of the Nlrp3 protein is associated with susceptibility to Crohn's disease. However, the role of Nlrp3 in colitis has not been characterized...
  82. pmc Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
    Sarah Kim
    Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Eur J Immunol 40:1545-51. 2010
    ..monocytogenes infection are only poorly defined. Here, we demonstrate that L. monocytogenes activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, L...
  83. pmc Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    J Immunol 184:4610-4. 2010
    ..We found that CD4(+) T cells deficient in ASC exhibited impaired survival; accordingly, ASC(-/-) mice had fewer myelin oligodendrocyte glycoprotein-specific T cells in the draining lymph nodes and CNS...
  84. pmc Influenza virus activates inflammasomes via its intracellular M2 ion channel
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 11:404-10. 2010
    ..virus that causes severe illness in humans and animals, stimulates the inflammasome through the Nod-like receptor NLRP3. However, the mechanism by which influenza virus activates the NLRP3 inflammasome is unknown...
  85. doi Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
    Christian Bauer
    Medizinische Klinik Innenstadt, University of Munich, Ziemssenstr 1, D 80336 Munich, Germany
    Gut 59:1192-9. 2010
    ..and crystalline substances, both cytokines are processed via the caspase-1-activating multiprotein complex, the NLRP3 inflammasome...
  86. pmc Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
    Jianghong Wu
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Immunol 30:693-702. 2010
    ..Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2, NLRC4, and NLRP3 inflammasomes as well as the adaptor protein ..
  87. doi Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes
    Kohsuke Tsuchiya
    Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 185:1186-95. 2010
    ..monocytogenes. Secretion of IL-1beta and IL-18 from Nod-like receptor family, pyrin domain containing 3 (NLRP3) and Nod-like receptor family, caspase-activating and recruitment domain containing 4 (NLRC4) knockout macrophages ..
  88. doi NALP3 is not necessary for early protection against experimental tuberculosis
    Kerstin Walter
    Division of Molecular Inflammation Medicine, Research Center Borstel, Borstel, Germany
    Immunobiology 215:804-11. 2010
    ..Here, we analyzed the relevance of NALP3, one component of the danger-signaling inflammasome, for (i) Mtb-induced cytokine secretion in vitro and in vivo, (..
  89. pmc The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
    Akosua Vilaysane
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Am Soc Nephrol 21:1732-44. 2010
    ..IL-1β, and IL-18 after unilateral ureteral obstruction (UUO) in mice, which suggested activation of the Nlrp3 inflammasome during renal injury...
  90. pmc Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
    Mohamed Lamkanfi
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    J Immunol 185:4385-92. 2010
    ..components apoptotic speck protein containing a caspase activation and recruitment domain (ASC), caspase 1 and Nalp3, whereas HMGB1 secretion from macrophages infected in vitro with Salmonella typhimurium was dependent on caspase 1 ..
  91. pmc Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity
    Janelle C Arthur
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 185:4515-9. 2010
    ..Both DCs and neutrophils fail to respond to chemokines in vitro. These findings indicate that NLRP12 is important in maintaining neutrophils and peripheral DCs in a migration-competent state...
  92. doi Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection
    Andrea J McCoy
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    J Immunol 185:7077-84. 2010
    ..requires the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain and both the NLRP3 and NLRC4 inflammasomes...
  93. doi Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice
    Ping Zhu
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hum Gene Ther 22:853-64. 2011
    ..Studies have indicated that NALP3 (NACHT domain, leucine-rich repeat [LRR] domain, and pyrin domain [PYD]-containing protein-3) inflammasome is ..
  94. doi Differential expression of NLRP3 among hematopoietic cells
    Greta Guarda
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    J Immunol 186:2529-34. 2011
    Although the importance of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in health and disease is well appreciated, a precise characterization of NLRP3 expression is yet undetermined...
  95. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Type I IFN signaling, via the STAT1 transcription factor, repressed the activity of the NLRP1 and NLRP3 inflammasomes, thereby suppressing caspase-1-dependent IL-1β maturation...
  96. doi NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant
    A G Besnard
    Université d Orléans and CNRS, Molecular Immunology and Embryology IEM, Orleans, France
    Allergy 66:1047-57. 2011
    ..Using an adjuvant-free model of allergic lung inflammation induced by ovalbumin (OVA), we investigated the role of NLRP3 inflammasome and related it to IL-1R1 signaling pathway.
  97. doi Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    Etsushi Kuroda
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Immunity 34:514-26. 2011
    ..Macrophages deficient in the inflammasome components caspase 1, NALP3, and ASC revealed that PGE₂ production was independent of the NALP3 inflammasome...
  98. pmc Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
    Leif E Sander
    Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 474:385-9. 2011
    ..Detection of vita-PAMPs triggers a state of alert not warranted for dead bacteria. Vaccine formulations that incorporate vita-PAMPs could thus combine the superior protection of live vaccines with the safety of dead vaccines...
  99. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011
    ..As the NLRP3 inflammasome and caspase-1 were shown to contribute to postischemic and postobstructive tubulointerstitial ..
  100. pmc Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious
    Ivonne Ceballos-Olvera
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002452. 2011
    ..Here we show that the Nod-like receptors (NLR) NLRP3 and NLRC4 differentially regulate pyroptosis and production of IL-1β and IL-18 and are critical for inflammasome-..
  101. pmc Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    Jorge Henao-Mejia
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 482:179-85. 2012
    ..Here, we show that the NLRP6 and NLRP3 inflammasomes and the effector protein IL-18 negatively regulate NAFLD/NASH progression, as well as multiple ..

Research Grants6

  1. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  3. Innate Immune Detection of Intracellular Pathogens
    RUSSELL VANCE; Fiscal Year: 2005
    ....
  4. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  5. Innate immune resistance to intracellular bacterial pathogens
    RUSSELL VANCE; Fiscal Year: 2007
    ..Such knowledge should contribute to rational approaches to designing novel antibacterial therapies. [unreadable] [unreadable] [unreadable]..
  6. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
    ..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..