Nlrp1a

Summary

Gene Symbol: Nlrp1a
Description: NLR family, pyrin domain containing 1A
Alias: CARD7, DEFCAP, Gm14, Gm15, NAC, Nalp1, Nalp1a, Nlrp1, PP1044, NACHT, LRR and PYD domains-containing protein 1a, NACHT, LRR and PYD containing protein 1, NACHT, leucine rich repeat and PYD containing 1, NACHT/LRR/pyrin domain-containing protein 1, NLR family, pyrin domain containing 1, NLR family, pyrin domain containing 1A, CAST/EiJ strain specific, NLR family, pyrin domain containing 1A, PWK/PhJ strain specific, NLR family, pyrin domain containing 1A, WSB/EiJ strain specific, OTTMUSCASG00059399, OTTMUSPWKG00059389, OTTMUSWSBG00059289, caspase recruitment domain protein, caspase recruitment domain-containing protein 7, death effector filament-forming Ced-4-like apoptosis protein, nucleotide-binding domain and caspase recruitment domain
Species: mouse

Top Publications

  1. pmc NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Immunity 37:1009-23. 2012
  2. pmc NLRP1 is an inflammasome sensor for Toxoplasma gondii
    Sarah E Ewald
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, California, USA
    Infect Immun 82:460-8. 2014
  3. pmc Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
    Thomas Brickler
    The Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Duck Pond Drive, Blacksburg, VA 24061, USA
    Mediators Inflamm 2016:6373506. 2016
  4. doi IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome
    Andrew J Murphy
    Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia Department of Immunology, Monash University, Melbourne 3004, Australia
    Cell Metab 23:155-64. 2016
  5. doi Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice
    Wen Hu
    Department of Pharmacology, Key Laboratory of Anti inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China
    Brain Behav Immun 52:58-70. 2016
  6. pmc The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis
    Tere M Williams
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061
    J Immunol 194:3369-80. 2015
  7. pmc The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes
    Nolan K Maier
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 194:2776-85. 2015
  8. pmc Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma
    Wei Chi
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China and
    Proc Natl Acad Sci U S A 111:11181-6. 2014
  9. pmc A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage
    Pierre Cavailles
    UMR 5163, Centre National de la Recherche Scientifique CNRS, Grenoble, France Université Grenoble 1, Grenoble, France
    PLoS Pathog 10:e1004005. 2014
  10. pmc Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes
    Nolan K Maier
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:763-70. 2014

Research Grants

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008

Scientific Experts

  • Inka Sastalla
  • HOLLY LALLMAN ROSENZWEIG
  • Li Chung Hsu
  • Nolan K Maier
  • Tere M Williams
  • Seth L Masters
  • Thomas Brickler
  • Andrew J Murphy
  • Wen Hu
  • Irving C Allen
  • Daniel E Rothschild
  • Mahtab Moayeri
  • Stephen H Leppla
  • Sarah E Ewald
  • Pierre Cavailles
  • Ben A Croker
  • Donald Metcalf
  • Wei Chi
  • Benjamin T Kile
  • Motti Gerlic
  • D Yang Wei Fann
  • Martina Kovarova
  • Kathleen M Averette
  • Greta Guarda
  • Jurg Tschopp
  • Eric D Boyden
  • Fabio Martinon
  • Dake Huang
  • Lachlan W Whitehead
  • Yuchan Wang
  • Ajithkumar Vasanthakumar
  • Michael J Kraakman
  • Sheryl Coutermarsh-Ott
  • Weiping Li
  • Armand Meza
  • Leonard C Harrison
  • Man K S Lee
  • Yaodong Zhang
  • Michelle H Theus
  • Louise Cengia
  • Axel Kallies
  • Weizu Li
  • Ladina Dirago
  • John M Wentworth
  • James E Vince
  • Mark A Febbraio
  • Rachael M Lane
  • Wenning Wu
  • Kate E Lawlor
  • Christian Stehlik
  • Kisha Gresham
  • Dragana Dragoljevic
  • Hélène L Kammoun
  • Yanyan Yin
  • Thomas E Cecere
  • Bettina Heid
  • Alysha E Simmons
  • Sheryl L Coutermarsh-Ott
  • Dylan K McDaniel
  • Rachel A Leeth
  • Olivier Bastien
  • Delphine Jublot
  • Corinne Loeuillet
  • John C Boothroyd
  • Hong Ouyang
  • Frances Wu
  • Cordelia Bisanz
  • Xuejiao Yang
  • Robert N Weinreb
  • Bastien Touquet
  • Joseph Chavarría-Smith
  • Devorah Crown
  • Yingting Zhu
  • Fei Li
  • Marie France Cesbron-Delauw
  • Yehong Zhuo
  • Jie Liu
  • Gilbert J Fournié
  • Pierre Flori
  • Ludovic Pilloux
  • Kang Zhang
  • Jian Ge
  • Céline Massera
  • Olivier Papapietro
  • Dominique Lagrange
  • Delphine Aldebert
  • Yandong Wang
  • Hongrui Chen
  • Sara Cristinelli
  • Jie Zhu

Detail Information

Publications23

  1. pmc NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Immunity 37:1009-23. 2012
    ..The NLRP1a inflammasome is expressed in hematopoietic progenitor cells and its activation triggers their pyroptotic death...
  2. pmc NLRP1 is an inflammasome sensor for Toxoplasma gondii
    Sarah E Ewald
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, California, USA
    Infect Immun 82:460-8. 2014
    ..Interleukin 1β (IL-1β) secretion by macrophage requires the effector caspases 1 and 11, the adapter ASC, and NLRP1, the sensor previously described to initiate the inflammasome response to Bacillus anthracis lethal factor...
  3. pmc Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
    Thomas Brickler
    The Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Duck Pond Drive, Blacksburg, VA 24061, USA
    Mediators Inflamm 2016:6373506. 2016
    ..IL-1β, IL-18, and IL-6 expression, contusion volume, hippocampal cell death, and motor behavior recovery in Nlrp1(-/-), Asc(-/-), and wild type mice after moderate controlled cortical impact (CCI) injury...
  4. doi IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome
    Andrew J Murphy
    Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia Department of Immunology, Monash University, Melbourne 3004, Australia
    Cell Metab 23:155-64. 2016
    ..We found that mice lacking the NLRP1 inflammasome phenocopy mice lacking IL-18, with spontaneous obesity due to intrinsic lipid accumulation...
  5. doi Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice
    Wen Hu
    Department of Pharmacology, Key Laboratory of Anti inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China
    Brain Behav Immun 52:58-70. 2016
    ..These results suggest that chronic GCs exposure may increase brain inflammation via NLRP-1 inflammasome activation and induce neurodegeneration...
  6. pmc The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis
    Tere M Williams
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061
    J Immunol 194:3369-80. 2015
    ..These data revealed that NLRP1, an inflammasome forming NLR, was significantly dysregulated in IBD and colon cancer...
  7. pmc The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes
    Nolan K Maier
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 194:2776-85. 2015
    ..Furthermore, in a murine anthrax infection model, 15d-PGJ2 reversed anthrax lethal toxin-mediated NLRP1-dependent resistance...
  8. pmc Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma
    Wei Chi
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China and
    Proc Natl Acad Sci U S A 111:11181-6. 2014
    ..and RGC death via a caspase-1-dependent pathway involving Nod-like receptor family, pyrin domain containing 1 (NLRP1)/NLRP3 inflammasomes and a caspase-1-independent pathway...
  9. pmc A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage
    Pierre Cavailles
    UMR 5163, Centre National de la Recherche Scientifique CNRS, Grenoble, France Université Grenoble 1, Grenoble, France
    PLoS Pathog 10:e1004005. 2014
    ..a distribution gradient that peaks at the bottom border of Toxo1, and highlighting the NOD-like receptor, Nlrp1a, as a major candidate...
  10. pmc Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes
    Nolan K Maier
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:763-70. 2014
    ..We discovered that arsenicals, including arsenic trioxide and sodium arsenite, inhibited activation of the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes by their respective activating signals, anthrax lethal toxin, nigericin, and ..
  11. pmc Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
    D Yang Wei Fann
    School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia
    Cell Death Dis 4:e790. 2013
    ..The objective of this study is to investigate dynamic responses of the NLRP1 and NLRP3 inflammasomes in stroke and to determine whether the NLRP1 and NLRP3 inflammasomes can be targeted with ..
  12. pmc Transcriptional analysis of the three Nlrp1 paralogs in mice
    Inka Sastalla
    Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Bethesda, MD 20892 3202, USA
    BMC Genomics 14:188. 2013
    ..to LT has been genetically linked to Nlrp1b, mice harbor two additional Nlrp1 paralogs in their genomes (Nlrp1a and Nlrp1c). However, little is known about their expression profile and sequence in different mouse strains...
  13. pmc NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice
    Martina Kovarova
    Pulmonary Division, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 189:2006-16. 2012
    ..Using a mouse line lacking expression of NLRP1, we show that assembly of this inflammasome in cells is triggered by a toxin from anthrax and that it initiates ..
  14. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    ..MDP challenge induces the association of NOD2 with another NLR protein, NALP1, and gel filtration analysis revealed the formation of a complex consisting of NOD2, NALP1, and caspase-1...
  15. pmc Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling
    H L Rosenzweig
    Department of Ophthalmology, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Mail Stop L467 IM, Portland, OR 97239, USA
    J Leukoc Biol 84:529-36. 2008
    ..This report reveals a new in vivo function of NOD2 within the eye yet importantly, distinguishes NOD2-dependent from NALP3-dependent inflammation, as ocular inflammation in mice occurred independently of IL-1beta...
  16. pmc Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent
    Kathleen M Averette
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e7913. 2009
    ..These data reveal a role for lysosomal membrane permeabilization in the cellular response to bacterial pathogens and demonstrate a shared requirement for cytosolic relocalization of cathepsins in pyroptosis and pyronecrosis...
  17. doi T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 460:269-73. 2009
    ..Inflammasome inhibition is observed for all tested NLRP1 (commonly called NALP1) and NLRP3 (NALP3 or cryopyrin) activators, whereas NLRC4 (IPAF) inflammasome function and ..
  18. ncbi NLRs join TLRs as innate sensors of pathogens
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Trends Immunol 26:447-54. 2005
    ....
  19. ncbi CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways
    Christian Stehlik
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:31941-9. 2003
    ..we detected specific binding of this CARD6-encoding protein to Nod1 (CARD4), Cardiak (Rip2/Rick), NAC (NALP1/DEFCAP/CARD7), and TUCAN (CARD8/Cardinal/NDPP/Dakar), caspase recruitment domain (CARD)-containing proteins implicated in ..
  20. ncbi Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    Eric D Boyden
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:240-4. 2006
    ....

Research Grants1

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..