Nlrc4

Summary

Gene Symbol: Nlrc4
Description: NLR family, CARD domain containing 4
Alias: 9530011P19Rik, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, Card12, IPAF, NLR family CARD domain-containing protein 4, caspase recruitment domain family, member 12, caspase recruitment domain-containing protein 12, ice protease-activating factor
Species: mouse

Top Publications

  1. doi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
  2. pmc NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways
    Stephen B Willingham
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 183:2008-15. 2009
  3. pmc Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
    F A Carvalho
    Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, Georgia, USA
    Mucosal Immunol 5:288-98. 2012
  4. pmc Malarial hemozoin is a Nalp3 inflammasome activating danger signal
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 4:e6510. 2009
  5. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
  6. pmc Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
    Marina Tiemi Shio
    Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000559. 2009
  7. pmc Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious
    Ivonne Ceballos-Olvera
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002452. 2011
  8. pmc Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4
    Anne Fortier
    Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
    Infect Immun 77:4794-805. 2009
  9. doi NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells
    Andreas Kupz
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 13:162-9. 2012
  10. pmc Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis
    Natalie N Whitfield
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 78:423-32. 2010

Research Grants

Scientific Experts

  • Nobuhiko Kayagaki
  • David Brough
  • Mikael E Sellin
  • Ryosuke Uchiyama
  • Craig Roy
  • Jorn Coers
  • Mohamed Lamkanfi
  • UMA NAGARAJAN
  • Edward A Miao
  • Luigi Franchi
  • Richard A Flavell
  • Jurg Tschopp
  • Fayyaz S Sutterwala
  • Gabriel Nunez
  • Thirumala Devi Kanneganti
  • Stephanie C Eisenbarth
  • Dario S Zamboni
  • Christopher L Case
  • Denise M Monack
  • Jenny P Y Ting
  • Irving C Allen
  • Sanjeev Mariathasan
  • Vishva M Dixit
  • Yasunori Ogura
  • Olaf Gross
  • Andrea J McCoy
  • Kim Newton
  • Marcelo S F Pereira
  • Greta Guarda
  • Amir S Yazdi
  • Russell E Vance
  • Takeshi Ichinohe
  • Karla L Lightfield
  • Hanfen Li
  • Anne Fortier
  • Thomas Henry
  • John Bertin
  • Jieling Yang
  • Yue Zhao
  • Yan Qu
  • Till Strowig
  • John Demian Sauer
  • Eric M Kofoed
  • Eran Elinav
  • Chengcheng Jin
  • Jakob von Moltke
  • Bo Hu
  • Toshihiko Suzuki
  • Petr Broz
  • Yuumi Nakamura
  • Claudia Toma
  • Naomi Higa
  • Yukiko Koizumi
  • Jong Hwan Park
  • Fabio Re
  • Yun Gi Kim
  • Aubry Tardivel
  • Catherine Dostert
  • Marina Tiemi Shio
  • Sarah E Warren
  • Stephen B Willingham
  • Shizuo Akira
  • Virginie Petrilli
  • Meron Roose-Girma
  • Ethan P Grant
  • David S Weiss
  • Amal Amer
  • Zehan Hu
  • Marco Túlio R Gomes
  • Taylor S Cohen
  • Dong Jae Kim
  • Andreas Kupz
  • Shanshan Cai
  • Els F Halff
  • Jianjin Shi
  • F A Carvalho
  • Hana Abdalla
  • Feng Shao
  • HILARIO J RAMOS
  • Zhiping Liu
  • Larissa D Cunha
  • Karina R Bortoluci
  • Norver J Trinidad
  • Syed Raza Ali
  • Jeffrey Tomalka
  • Ivonne Ceballos-Olvera
  • Stefan K Drexler
  • Haitao Wen
  • Rongbin Zhou
  • Katherine A Fitzgerald

Detail Information

Publications96

  1. doi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
    ..These data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections...
  2. pmc NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways
    Stephen B Willingham
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 183:2008-15. 2009
    ..These results provide critical in vivo validation that the physiologic role of NLRP3 and ASC is not limited to inflammasome formation...
  3. pmc Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
    F A Carvalho
    Center for Inflammation, Immunity and Infection, Department of Biology, Georgia State University, Atlanta, Georgia, USA
    Mucosal Immunol 5:288-98. 2012
    ..Therefore, we examined the role of the intracellular flagellin receptor, NLRC4, in protecting the gut and/or driving inflammation...
  4. pmc Malarial hemozoin is a Nalp3 inflammasome activating danger signal
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 4:e6510. 2009
    ..Thus, we hypothesized that hemozoin could activate the Nalp3 inflammasome, due to its particulate nature reminiscent of other inflammasome-activating agents...
  5. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
    ..Nlrp3-deficient mice also demonstrated increased susceptibility to infection with C. albicans, which is consistent with a key role for Nlrp3 in innate immune responses to the pathogen C. albicans...
  6. pmc Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
    Marina Tiemi Shio
    Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000559. 2009
    ..and inflammation are dependent on NOD-like receptor containing pyrin domain 3 (NLRP3), ASC and caspase-1, but not NLRC4 (NLR containing CARD domain)...
  7. pmc Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious
    Ivonne Ceballos-Olvera
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002452. 2011
    ..Here we show that the Nod-like receptors (NLR) NLRP3 and NLRC4 differentially regulate pyroptosis and production of IL-1β and IL-18 and are critical for inflammasome-mediated ..
  8. pmc Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4
    Anne Fortier
    Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
    Infect Immun 77:4794-805. 2009
    ..pneumophila. Moreover, macrophages doubly heterozygous (Naip5AJ/WT Irf8R294C/WT or Nlrc4-/+ Irf8R294C/WT) for combined loss-of-function mutations in Irf8 and in either Naip5 or Nlrc4 are highly ..
  9. doi NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells
    Andreas Kupz
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 13:162-9. 2012
    ..We discovered an in vivo link between flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells (DCs) and host protective interferon-γ (IFN-γ) secretion by ..
  10. pmc Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis
    Natalie N Whitfield
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 78:423-32. 2010
    ..Once detected by the NOD-like receptors Naip5 and Ipaf (Nlrc4), flagellin triggers pyroptosis, a proinflammatory cell death. In contrast, motile strains of L. parisiensis and L...
  11. pmc A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans
    Jeffrey Tomalka
    Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, Ohio, United States of America
    PLoS Pathog 7:e1002379. 2011
    ..Here we show that mucosal expression of NLRP3 and NLRC4 is induced by Candida infection, and up-regulation of these molecules is impaired in NLRP3 and NLRC4 deficient ..
  12. doi Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan
    Himanshu Kumar
    Laboratory of Host Defense
    J Immunol 183:8061-7. 2009
    ..Collectively, these findings reveal a critical role for the NLRP3 inflammasome in the regulation of antifungal innate immune responses as well as B cell activation...
  13. pmc Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis
    Tatiana N Silveira
    Department of Cell Biology, University of Sao Paulo, Medical School Ribeirão Preto, SP 14049 900 Brazil
    Infect Immun 78:1403-13. 2010
    ..We found that regardless of Dot/Icm activity, pore formation does not occur in BMMs deficient in caspase-1 and Nlrc4/Ipaf...
  14. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
    ..We show here that NLRC4/Ipaf detects the basal body rod component of the T3SS apparatus (rod protein) from S...
  15. pmc Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
    Sarah Kim
    Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Eur J Immunol 40:1545-51. 2010
    ..monocytogenes. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria...
  16. doi Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo
    Marcelo S F Pereira
    Department of Cell Biology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    J Immunol 187:6447-55. 2011
    Although NLRC4/IPAF activation by flagellin has been extensively investigated, the downstream signaling pathways and the mechanisms responsible for infection clearance remain unclear...
  17. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  18. doi The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    Yue Zhao
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Nature 477:596-600. 2011
    ..The inflammasome assembled by the NOD-like receptor (NLR) protein NLRC4 responds to bacterial flagellin and a conserved type III secretion system (TTSS) rod component...
  19. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
    ..Finally, AIM2-deficient mice displayed increased susceptibility to F. tularensis infection compared with wild-type mice. Their increased bacterial burden in vivo confirmed that AIM2 is essential for an effective innate immune response...
  20. pmc Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
    Jianghong Wu
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Immunol 30:693-702. 2010
    ..Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2, NLRC4, and NLRP3 inflammasomes as well as the adaptor ..
  21. pmc Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
    Eric M Kofoed
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 477:592-5. 2011
    ..The inflammasome that contains the NLRC4 (NLR family, CARD domain containing 4) protein was previously shown to be activated in response to two distinct ..
  22. pmc Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA, USA
    J Exp Med 207:1745-55. 2010
    ..However, the NLRs that respond to microbial pathogens in vivo are poorly defined. We show that the NLRs NLRP3 and NLRC4 both activate caspase-1 in response to Salmonella typhimurium...
  23. pmc NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    Eran Elinav
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 145:745-57. 2011
    ..Altogether, perturbations in this inflammasome pathway, including NLRP6, ASC, caspase-1, and IL-18, may constitute a predisposing or initiating event in some cases of human IBD...
  24. pmc Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    Haitao Wen
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Immunol 12:408-15. 2011
    ..Furthermore, IL-1β affects insulin sensitivity through tumor necrosis factor-independent and dependent pathways. These findings provide insights into the association of inflammation, diet and T2D...
  25. pmc Differential requirements for NAIP5 in activation of the NLRC4 inflammasome
    Karla L Lightfield
    School of Public Health, Division of Immunology and Pathogenesis, University ofCalifornia, Berkeley, California 94720, USA
    Infect Immun 79:1606-14. 2011
    ..The inflammasome containing the nucleotide binding domain-leucine-rich repeat (NBD-LRR) protein NLRC4 (interleukin-converting enzyme protease-activating factor [IPAF]) responds to the cytosolic presence of bacterial ..
  26. pmc Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
    Mohamed Lamkanfi
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    J Immunol 185:4385-92. 2010
    ..HMGB1 secretion from macrophages infected in vitro with Salmonella typhimurium was dependent on caspase 1 and Ipaf. Thus, HMGB1 secretion, which is critical for endotoxemia, occurs downstream of inflammasome assembly and caspase 1 ..
  27. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
    ..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas...
  28. doi A role for mitochondria in NLRP3 inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 469:221-5. 2011
    ..This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases...
  29. doi Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection
    Andrea J McCoy
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    J Immunol 185:7077-84. 2010
    ..the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain and both the NLRP3 and NLRC4 inflammasomes...
  30. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..flagellin was cleared by the cytosolic flagellin-detection pathway through the activation of caspase-1 by the NLRC4 inflammasome; however, this clearance was independent of IL-1β and IL-18...
  31. pmc TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Eur J Immunol 40:3528-34. 2010
    ..induce cytokines and elicit/promote murine antibody responses upon deletion of the flagellin receptors TLR5 and/or NLRC4 (also referred to as IPAF) using a prime/boost regimen...
  32. pmc Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    Bo Hu
    Department of Immunobiology, Section of Comparative Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:21635-40. 2010
    ..We suggest a model in which the NLRC4 inflammasome is central to colonic inflammation-induced tumor formation through regulation of epithelial cell ..
  33. pmc Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
    Fayyaz S Sutterwala
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:3235-45. 2007
    ..We show that infection of macrophages with P. aeruginosa results in activation of caspase-1 in an IPAF-dependent, but flagellin-independent, manner...
  34. pmc Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 202:1043-9. 2005
    ....
  35. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  36. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
    ..b>Ipaf, a cytosolic pattern-recognition receptor in the family of nucleotide-binding oligomerization domain-leucine-rich ..
  37. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
    Macrophages respond to Salmonella typhimurium infection via Ipaf, a NACHT-leucine-rich repeat family member that activates caspase-1 and secretion of interleukin 1beta...
  38. pmc Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
    Maria Lara-Tejero
    Section of Microbial Pathogenesis, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Exp Med 203:1407-12. 2006
    ..We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection...
  39. ncbi Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
    Amal Amer
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:35217-23. 2006
    ..Mouse macrophages lacking the NLR protein Ipaf or its downstream effector caspase-1 are permissive to intracellular Legionella replication...
  40. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
    ..The adaptors ASC, Ipaf and RIP2 have each been proposed to regulate caspase-1 (also called interleukin (IL)-1 converting enzyme), which is ..
  41. ncbi MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3
    Qilin Pan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Leukoc Biol 82:177-83. 2007
    ..Together, our data provide a new understanding of this important pathway of IL-1beta production and allow for further studies of the role of these proteins within the broader context of inflammatory disease...
  42. ncbi Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    Thirumala Devi Kanneganti
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Immunity 26:433-43. 2007
    ..However, unlike Ipaf-dependent caspase-1 activation, stimulation of the pannexin-1-cryopyrin pathway by several intracellular bacteria ..
  43. ncbi The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation
    Mohamed Lamkanfi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    J Immunol 178:8022-7. 2007
    Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease...
  44. ncbi Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    V Petrilli
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, Center of Immunology Lausanne, Epalinges 1066, Switzerland
    Cell Death Differ 14:1583-9. 2007
    ..The inflammasomes harboring the NLR members NALP1, NALP3 and IPAF have been best characterized...
  45. pmc Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
    Christopher L Case
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 110:1851-6. 2013
    ..Legionella activation of caspase-11 induced pyroptosis by a mechanism independent of the NAIP/NLRC4 and caspase-1 axis. Legionella activation of caspase-11 stimulated activation of caspase-1 through NLRP3 and ASC...
  46. ncbi Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 37:3030-9. 2007
    ..Here we report that the Nod-like receptor family member Ipaf is required for optimal bacterial clearance in an in vivo model of P. aeruginosa lung infection...
  47. pmc Pseudomonas aeruginosa activates caspase 1 through Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 105:2562-7. 2008
    ..Macrophages respond to Salmonella typhimurium infection by activating caspase 1 through the NLR Ipaf. This activation is mediated by cytosolic flagellin through the activity of the virulence-associated type III ..
  48. pmc Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    Karla L Lightfield
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Nat Immunol 9:1171-8. 2008
    ..These mice failed to activate the inflammasome in response to the 35 amino acids of flagellin or in response to Legionella pneumophila infection. Our data clarify the molecular basis for the cytosolic response to flagellin...
  49. pmc The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 30:566-75. 2009
    ..These findings reveal a function of the cryopyrin inflammasome in healing responses. Thus, cryopyrin and caspase-1 are central to both innate immunity and to moderating lung pathology in influenza pneumonia...
  50. pmc The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 30:556-65. 2009
    ..Mice lacking Nlrp3, Pycard, or caspase-1, but not Nlrc4, exhibited dramatically increased mortality and a reduced immune response after exposure to the influenza virus...
  51. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
    ..Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(-/-) (Ipaf(-/-)), and caspase-1(-/-) derived macrophages. Particularly, caspase-1 activation is detected during L...
  52. doi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
    ..Thus, our results demonstrate the molecular basis for IL-1beta production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo...
  53. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..pathway involving the host nucleotide-binding domain and leucine-rich repeat-containing protein Ipaf (NLRC4)...
  54. pmc NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Immunol 13:449-56. 2012
    ..infection with pathogenic Salmonella or Pseudomonas, intestinal phagocytes produced mature IL-1β through the NLRC4 inflammasome but did not produce tumor necrosis factor (TNF) or IL-6...
  55. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
  56. pmc NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection
    Shanshan Cai
    Laboratory of Lung Biology, Department of Pathobiological Sciences, Center for Experimental Infectious Disease Research, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 188:5623-35. 2012
    Bacterial flagellin is critical to mediate NLRC4 inflammasome-dependent caspase-1 activation...
  57. doi The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    Daniel A Muruve
    Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nature 452:103-7. 2008
    ..Thus, in addition to viral and bacterial components or danger signals in general, inflammasomes sense potentially dangerous cytoplasmic DNA, strengthening their central role in innate immunity...
  58. doi Phosphorylation of NLRC4 is critical for inflammasome activation
    Yan Qu
    Department of Physiological Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 490:539-42. 2012
    b>NLRC4 is a cytosolic member of the NOD-like receptor family that is expressed in innate immune cells...
  59. pmc Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin
    Els F Halff
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Biol Chem 287:38460-72. 2012
    The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagellin...
  60. pmc Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
    ..This is likely to affect how we design effective, but safe, adjuvants in the future...
  61. pmc Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    Sarah E Warren
    Department of Immunology, University of Washington, Seattle WA 98195, USA
    J Immunol 180:7558-64. 2008
    ..within the cytosolic compartment induces caspase 1 activation through multiple Nod-like receptors, including Ipaf and Nalp3. Flagellin expression by cytosolic L. monocytogenes was detected through Ipaf in a dose-dependent manner...
  62. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  63. pmc The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells
    Dong Jae Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang eup, Cheongwon Gun, Choongbuk, Korea
    Eur J Immunol 43:2650-8. 2013
    ..These studies identify bacterial cag pathogenicity island and the cooperative interaction among host innate receptors TLR2, NOD2, and NLRP3 as important regulators of IL-1β production in H. pylori infected DCs. ..
  64. pmc Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation
    Jieling Yang
    National Institute of Biological Sciences, Beijing 102206, China
    Proc Natl Acad Sci U S A 110:14408-13. 2013
    ..Needle protein activation of human NRL family CARD domain containing 4 (NLRC4) inflammasome requires the sole human neuronal apoptosis inhibitory protein (hNAIP)...
  65. doi Crystal structure of NLRC4 reveals its autoinhibition mechanism
    Zehan Hu
    School of Life Sciences, Tsinghua University, and Tsinghua Peking Center for Life Sciences, Beijing 100084, China
    Science 341:172-5. 2013
    ..Their autoinhibition mechanism remains poorly defined. Here, we report the crystal structure of mouse NLRC4 in a closed form...
  66. pmc Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia
    Taylor S Cohen
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 123:1630-7. 2013
    ..patterns that activate NF-κB signaling in epithelial and immune cells, but also flagella that activate the NLRC4 inflammasome...
  67. doi Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
    Marco Túlio R Gomes
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270 901 Brazil
    J Immunol 190:3629-38. 2013
    ..Therefore, we decided to investigate the function of NLRC4, NLRP3, and AIM2 in sensing Brucella...
  68. pmc IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection
    HILARIO J RAMOS
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Pathog 8:e1003039. 2012
    ....
  69. pmc Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    Hanfen Li
    Department Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 181:17-21. 2008
    ..the NLR (nucleotide-binding domain leucine-rich repeat-containing) protein NLRP3 and its adaptor ASC, but not by NLRC4. Other particulate adjuvants, such as QuilA and chitosan, induce inflammasome activation in a NLRP3-dependent ..
  70. pmc Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis
    Hana Abdalla
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e40722. 2012
    ..Interleukin-1β (IL-1β) is important for host resistance against Mycobacterium tuberculosis (Mtb) infections. The response of the dendritic cell inflammasome during Mtb infections has not been investigated in detail...
  71. pmc Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
    Jakob von Moltke
    Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California at Berkeley, Berkeley, California 94720, USA
    Nature 490:107-11. 2012
    ..delivery of bacterial flagellin, a specific ligand for the NAIP5 (NLR family, apoptosis inhibitory protein 5)/NLRC4 (NLR family, CARD-domain-containing 4) inflammasome...
  72. pmc Role of inflammasomes in host defense against Citrobacter rodentium infection
    Zhiping Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:16955-64. 2012
    ..rodentium has not been characterized. Here, we show that mice lacking the inflammasome components Nlrp3, Nlrc4, and caspase-1 were hypersusceptible to C. rodentium-induced gastrointestinal inflammation...
  73. doi Cutting edge: Necrosis activates the NLRP3 inflammasome
    Hanfen Li
    Department Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 183:1528-32. 2009
    ..Our study identifies a new mechanism through which necrosis generates proinflammatory molecules that contributes to the sterile inflammatory response...
  74. ncbi Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila
    Anne Fortier
    Department of Biochemistry, Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    Cell Microbiol 9:910-23. 2007
    ..pneumophila products by Birc1e/Naip5 in macrophages occurs rapidly following phagocytosis, a process that antagonizes the ability of L. pneumophila to remodel its phagosome into a specialized vacuole with ER characteristics...
  75. ncbi Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways
    Jorn Coers
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell Microbiol 9:2344-57. 2007
    ..growth remains poorly understood, but is known to require the cytosolic microbe sensors Naip5 (Birc1e) and Ipaf. We hypothesized that Naip5 and Ipaf may act in partnership with other antimicrobial signalling pathways in ..
  76. ncbi ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    ..phagocytophilum. The NLR family member IPAF/NLRC4, but not NALP3/NLRP3, was partially required for IFN-gamma production in response to A. phagocytophilum...
  77. pmc The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 38:2085-9. 2008
    ..speck-like protein containing a caspase recruitment domain (Asc) but not the NLR family, CARD domain containing 4 (Nlrc4) protein...
  78. pmc Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
    Avlin B Imaeda
    Section of Digestive Diseases, Yale University, New Haven, Connecticut 06520 8019, USA
    J Clin Invest 119:305-14. 2009
    ..In summary, we have identified a 2-signal requirement (Tlr9 and the Nalp3 inflammasome) for acetaminophen-induced hepatotoxicity and some potential therapeutic approaches...
  79. pmc Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
    Yuumi Nakamura
    Department of Dermatology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    J Exp Med 206:1037-46. 2009
    ..Our findings implicate MCs as IL-1beta producers in the skin and mediators of histamine-independent urticaria through the NLRP3 inflammasome...
  80. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..The current use of nano-TiO(2) may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure...
  81. pmc Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor
    Jurgen Harder
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 183:5823-9. 2009
    ..pyogenes peritoneal infection. These results indicate that caspase-1 activation in response to S. pyogenes infection requires NF-kappaB and the virulence factor streptolysin O, but proceeds independently of P2X7R and TLR signaling...
  82. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
    ..These findings suggest that the inhibition of Nlrp3 inflammasome activity can diminish the acute inflammation and damage associated with tissue injury...
  83. doi Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling
    Claudia Toma
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa
    J Immunol 184:5287-97. 2010
    ..Our results identify the NLRP3 inflammasome as a sensor of Vibrio infections through the action of bacterial cytotoxins and differential activation of innate signaling pathways acting upstream of NF-kappaB...
  84. pmc Influenza virus activates inflammasomes via its intracellular M2 ion channel
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 11:404-10. 2010
    ..Our results show a mechanism by which influenza virus infection activates inflammasomes and identify the sensing of disturbances in intracellular ionic concentrations as a previously unknown pathogen-recognition pathway...
  85. pmc The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    Irving C Allen
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Exp Med 207:1045-56. 2010
    ..domain, leucine-rich-repeat-containing (NLR) component that is involved in colitis and CAC, we assessed Nlrp3 and Nlrc4 deficient mice...
  86. pmc The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    Hua Tang
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:608-17. 2010
    ..Thus, the T(H)2 response to cysteine proteases requires DC-basophil cooperation via ROS-mediated signaling...
  87. pmc NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
    Chengcheng Jin
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:14867-72. 2011
    ..These results demonstrate that the NLRP3 inflammasome mediates the pathological effect of HA crystals in vitro and in vivo and suggest a critical role for the inflammasome in the pathogenesis of OA...
  88. pmc Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA
    MBio 2:. 2011
    ..NLR-mediated activation of caspase-1 by Legionella pneumophila occurs through both an NLRC4/NAIP5-dependent pathway and a pathway requiring the adapter protein Asc...
  89. pmc Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity
    John Demian Sauer
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Proc Natl Acad Sci U S A 108:12419-24. 2011
    ..of Listeria monocytogenes that ectopically expresses Legionella pneumophila flagellin, a potent activator of the Nlrc4 inflammasome. Compared with wild-type L...
  90. pmc The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis
    Marcelo S F Pereira
    Department of Cell Biology, School of Medicine of Ribeirao Preto, Faculdade de Medicina de Ribeirao Preto, Universidade de São Paulo Ribeirão Preto, Sao Paulo, Brazil
    Front Microbiol 2:33. 2011
    The Nlrc4 inflammasome is triggered in response to contamination of the host cell cytoplasm with bacterial flagellin, which induces pyroptosis, a form of cell death that accounts for restriction of bacterial infections...
  91. pmc Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage
    Syed Raza Ali
    Laboratory of Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California, USA
    Immunity 35:34-44. 2011
    ..Prevention of cell death or ATP release through constitutive p38 or AKT activation interfered with inflammasome activation and IL-1β production, thereby compromising antimicrobial immunity...
  92. pmc A novel pathway for inducible nitric-oxide synthase activation through inflammasomes
    Carina L Buzzo
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508 900, Brazil
    J Biol Chem 285:32087-95. 2010
    Innate immune recognition of flagellin is shared by transmembrane TLR5 and cytosolic Nlrc4 (NOD-like receptor family CARD (caspase activation recruitment domain) domain containing 4)/Naip5 (neuronal apoptosis inhibitory protein 5)...
  93. pmc Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes
    R K Subbarao Malireddi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Immunol 185:3127-30. 2010
    ..In this article, we show that activation of the Nlrp3 and Nlrc4 inflammasomes induces processing of full-length PARP1 into a fragment of 89 kDa in a stimulus-dependent manner...
  94. doi Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages
    Andrea J McCoy
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    Eur J Immunol 40:2797-803. 2010
    ..speck-like protein containing a caspase recruitment domain (ASC), but not NLR family, CARD domain containing 4 (NLRC4)...
  95. doi Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF
    Laeticia Kolly
    Service of Rheumatology, Departement de l appareil locomoteur, Centre Hospitalier Universitaire Vaudois and University of Lausanne, University of Lausanne, Lausanne, Switzerland
    J Immunol 183:4003-12. 2009
    ..in human and murine arthritis, we investigated the contribution of the inflammasome components ASC, NALP-3, IPAF, and caspase-1 to inflammatory arthritis...
  96. ncbi Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Immunol 181:3755-9. 2008
    ..We propose that, in addition to TLR stimulators, agonists of the NALP3 inflammasome should also be considered as vaccine adjuvants...

Research Grants1

  1. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
    ..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..