Nkx2-1

Summary

Gene Symbol: Nkx2-1
Description: NK2 homeobox 1
Alias: AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1, homeobox protein Nkx-2.1, thyroid nuclear factor 1, thyroid transcription factor 1, thyroid-specific enhancer-binding protein, tinman
Species: mouse

Top Publications

  1. ncbi The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary
    S Kimura
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 10:60-9. 1996
  2. ncbi Origins of cortical interneuron subtypes
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:2612-22. 2004
  3. ncbi Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
  4. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
  5. doi NKX2.1 specifies cortical interneuron fate by activating Lhx6
    Tonggong Du
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 135:1559-67. 2008
  6. pmc Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    Yan Geng
    Model Animal Research Center, Nanjing University, Nanjing 210061, China
    Proc Natl Acad Sci U S A 108:7058-63. 2011
  7. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
  8. ncbi Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation
    Susan E Wert
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Dev Biol 242:75-87. 2002
  9. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
  10. ncbi A mouse model for hereditary thyroid dysgenesis and cleft palate
    M De Felice
    Stazione Zoologica Anton Dohrn, Napoli, Italy
    Nat Genet 19:395-8. 1998

Research Grants

  1. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  2. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
  3. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  5. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  6. Role of NFI in type II Cell Function
    CINDY BACHURSKI; Fiscal Year: 2006
  7. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
  8. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications166 found, 100 shown here

  1. ncbi The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary
    S Kimura
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 10:60-9. 1996
    ..These results establish that the expression of T/EBP, a transcription factor known to control thyroid-specific gene transcription, is also essential for organogenesis of the thyroid, lung, ventral forebrain, and pituitary...
  2. ncbi Origins of cortical interneuron subtypes
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:2612-22. 2004
    ..By establishing spatial differences in the origins of interneuron subtypes, these studies lay the groundwork for elucidating the molecular bases for their distinct differentiation pathways...
  3. ncbi Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
    ..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
  4. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In addition, the transcription of several mesenchymally expressed downstream targets of Shh is abolished. These results highlight the importance of epithelially derived Shh in regulating branching morphogenesis of the lung...
  5. doi NKX2.1 specifies cortical interneuron fate by activating Lhx6
    Tonggong Du
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 135:1559-67. 2008
    ..1. The slice transfection and transplantation methods employed here are beginning to uncover embryonic mechanisms for specifying neuronal fates that only become definable postnatally...
  6. pmc Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    Yan Geng
    Model Animal Research Center, Nanjing University, Nanjing 210061, China
    Proc Natl Acad Sci U S A 108:7058-63. 2011
    ..Therefore, we provide in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling...
  7. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..These results demonstrate a critical role for Nkx2.1 in morphogenesis of the anterior foregut and the lung as well as in differentiation of pulmonary epithelial cells...
  8. ncbi Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation
    Susan E Wert
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Dev Biol 242:75-87. 2002
    ..Increased expression of TTF-1 altered alveolarization and caused chronic pulmonary inflammation, demonstrating that precise regulation of TTF-1 is critical for homeostasis in the postnatal lung...
  9. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
    ..Thus, our results indicate that FGF10 plays a pivotal role in maintaining epithelial progenitor cell proliferation as well as coordinating alveolar smooth muscle cell formation and vascular development...
  10. ncbi A mouse model for hereditary thyroid dysgenesis and cleft palate
    M De Felice
    Stazione Zoologica Anton Dohrn, Napoli, Italy
    Nat Genet 19:395-8. 1998
    ..Thus, mutation of Titf2-/- results in neonatal hypothyroidism that shows similarity to thyroid dysgenesis in humans...
  11. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
  12. pmc Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development
    Margarita García-López
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 506:46-74. 2008
    ..Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala...
  13. ncbi Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1
    Jose G Pichel
    Group of Growth Factors in Vertebrate Development, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mech Dev 120:349-61. 2003
    ..LIF and IGF-I, thus, have cooperative and distinct tissue functions during development. Their essential role in bone ossification apparently involves Sp3, and in lung maturation Sp3 together with TTF-1...
  14. doi The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors
    Nicolas Jonckheere
    INSERM, U837, Jean Pierre Aubert Research Center, Lille, France
    FEBS J 278:282-94. 2011
    ..The characterization of the structural and functional features of the Muc5b mucin gene will provide us with a strong base to develop studies in murine models aimed at the identification of its biological role in lung pathophysiology...
  15. pmc Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation
    Yutaka Maeda
    Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 184:421-9. 2011
    ..Elucidation of the molecular mechanisms regulating mucous metaplasia and hypersecretion provides the scientific basis for diagnostic and therapeutic opportunities to improve the care of chronic pulmonary diseases...
  16. ncbi Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung
    L Zhou
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Histochem Cytochem 44:1183-93. 1996
    ..The early expression of TTF-1 and HNF-3beta, preceding and overlapping that of pro-SP-B, mature SP-B, pro-SP-C, and CCSP, supports a regulatory role for TTF-1 and HNF-3beta in lung-specific gene expression...
  17. doi Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 327:106-20. 2009
    ..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis...
  18. ncbi Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1
    M D Bruno
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039
    J Biol Chem 270:6531-6. 1995
    ..TTF-1 interacts with complex protein/DNA binding sites located in the 5'-flanking region of the murine SP-A gene enhancing lung epithelial cell-specific expression in vitro...
  19. ncbi Distinct cortical migrations from the medial and lateral ganglionic eminences
    S A Anderson
    Nina Ireland Laboratory of Developmental Neuroscience, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Development 128:353-63. 2001
    ..In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons...
  20. ncbi Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning
    Joshua G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 130:4895-906. 2003
    ..1 dependent specification of oligodendrocytes. Therefore, both integrative and antagonistic interactions between homeodomain-containing transcription factors contribute to the patterning of the telencephalon...
  21. ncbi Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression
    Zhan Yin
    Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Am J Physiol Lung Cell Mol Physiol 291:L191-9. 2006
    ..Thus Hop represents a novel regulator of pulmonary maturation that is induced by glucocorticoids to mediate functionally important HDAC-dependent negative feedback regulation...
  22. pmc Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
    Oleg V Lagutin
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Genes Dev 17:368-79. 2003
    ..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate...
  23. ncbi Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor
    Lars C Moeller
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Endocrinol 17:2295-302. 2003
    Humans expressing one allele of the thyroid transcription factor 1 (TTF1) gene have neurological symptoms and increased serum TSH with variable degrees of hypothyroidism...
  24. ncbi Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells
    Vrushank Dave
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:34578-88. 2004
    ..Components of the calcineurin/NFAT pathway were identified in respiratory epithelial cells of the lung that potentially augment rapid assembly of a multiprotein transcription complex on Sftpd promoter inducing SP-D expression...
  25. pmc Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis
    Yina Li
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB3, Nashville, TN 37232, USA
    Dev Biol 322:145-55. 2008
    ..Our finding sheds light on human tracheal malformations by providing a novel mouse model implicating Bmp signaling, non-canonical Erk activation and cellular proliferation...
  26. pmc Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene
    YuXia Cao
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:2152-64. 2010
    ..b>Thyroid transcription factor 1 (Nkx2-1) regulates Sftpb gene expression in various species...
  27. pmc Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors
    Jean Bosco Tagne
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e29907. 2012
    ....
  28. pmc Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma
    Eric L Snyder
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Mol Cell 50:185-99. 2013
    ..These observations suggest that loss of both active and latent differentiation programs is required for tumors to reach a primitive, poorly differentiated state...
  29. pmc Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland
    M P Postiglione
    Laboratory of Biochemistry and Molecular Biology, Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 99:15462-7. 2002
    ..Furthermore, our data indicate that in embryonic life TSH does not play an equivalent role in controlling gland growth as in the adult thyroid...
  30. ncbi The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation
    Henrik Fagman
    Institute of Anatomy and Cell Biology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Dev Dyn 235:444-55. 2006
    ..Thyroid precursor cells expressing Titf1/Nkx2...
  31. ncbi Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles
    Y Ohkubo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, P O Box 0984, San Francisco, CA 94143 0984, USA
    Neuroscience 111:1-17. 2002
    ....
  32. ncbi Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
    Elaine E Storm
    Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
    Development 133:1831-44. 2006
    ..These data suggest that Fgf8 functions to coordinate multiple patterning centers, and that modifications in the relative strength of FGF signaling can have profound effects on the relative size and nature of telencephalic subdivisions...
  33. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
  34. pmc Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 276:403-15. 2004
    ..In conclusion, FGFR2, but not FGFR1, appears crucial for ureteric bud branching morphogenesis and stromal mesenchyme patterning...
  35. pmc Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity
    S Guazzi
    European Molecular Biology Laboratory EMBL, Heidelberg, FRG
    EMBO J 9:3631-9. 1990
    ....
  36. pmc CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression
    Takeshi Tomita
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 283:25617-27. 2008
    ....
  37. pmc TTF-1 regulates α5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium
    Paul R Reynolds
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Respir Res 11:175. 2010
    ..5 is a structural subunit detected in many non-neuronal tissues; however, its function during pulmonary development is unknown...
  38. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  39. ncbi Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos
    B Yuan
    Department of Pediatrics, Women s and Children s Hospital, USC School of Medicine, Los Angeles, California 90033, USA
    Dev Dyn 217:180-90. 2000
    ..1 independent, while distal lung morphogenesis appears to be strictly dependent on the wild-type activity of Nkx2.1...
  40. ncbi Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    H L Park
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology and Physiology and Neuroscience, New York University Medical School, New York, NY 10016, USA
    Development 127:1593-605. 2000
    ..Furthermore, Gli1 and Gli2, but not Gli1 and Gli3, have extensive overlapping functions that are likely downstream of SHH signaling...
  41. ncbi GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression
    Cong Liu
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:4519-25. 2002
    ..GATA-6 influenced the activity of the sp-C promoter, binding and acting synergistically with TTF-1...
  42. ncbi beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  43. ncbi Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    ..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
  44. pmc Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid
    Takashi Kusakabe
    Laboratory of Metabolism, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 20:1796-809. 2006
    ..Taken together, these results suggest that T/ebp/Nkx2.1 is required for maintenance of the normal architecture and function of differentiated thyroids...
  45. ncbi Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult
    Milutin Milenkovic
    IRIBHM, Erasme University Hospital, Free University of Brussels, Route de Lennik, 808, 1070 Brussels, Belgium
    J Endocrinol 192:615-26. 2007
    ..It is not always correlated with the overall thyroid H(2)O(2) accumulation, highlighting the importance of additional regulatory mechanisms which control either the production or H(2)O(2) degradation...
  46. ncbi Longitudinal organization of the anterior neural plate and neural tube
    K Shimamura
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Development 121:3923-33. 1995
    ....
  47. ncbi Inductive interactions direct early regionalization of the mouse forebrain
    K Shimamura
    Department of Psychiatry and Langley Porter Psychiatric Institute, University of California at San Francisco, 94143 0984, USA
    Development 124:2709-18. 1997
    ....
  48. ncbi Follicular cells of the thyroid gland require Pax8 gene function
    A Mansouri
    MPI of Biophysical Chemistry, Dept of Molecular Cell Biology, Gottingen, Germany
    Nat Genet 19:87-90. 1998
    ..We present evidence that Pax8 is necessary for providing cues for the differentiation of competent endoderm primordia into thyroxin-producing follicular cells...
  49. ncbi Sonic hedgehog is essential to foregut development
    Y Litingtung
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Nat Genet 20:58-61. 1998
    ..These results indicate that Shh is required for the growth and differentiation of the oesophagus, trachea and lung, and suggest that mutations in SHH and its signalling components may be involved in foregut defects in humans...
  50. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
  51. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
    ..In the basal telencephalon, these DLX-positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb...
  52. ncbi NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos
    O Pabst
    Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D 38106 Braunschweig, Germany
    Dev Genes Evol 210:47-50. 2000
    ..We found that expression of NKX2.1, NKX2.2, and NKX2.9 in neural domains requires Shh signaling, whereas NKX2.3, NKX2.5 and NKX2.6 expression in endoderm and mesoderm is independent of Shh...
  53. ncbi Origin and molecular specification of striatal interneurons
    O Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Neurosci 20:6063-76. 2000
    ..Finally, we hypothesize that, within the MGE, radially migrating cells generally become projection neurons, whereas tangentially migrating cells mainly form interneurons of the striatum and cerebral cortex...
  54. ncbi The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development
    R Keijzer
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Development 128:503-11. 2001
    ..Taken together, these data demonstrate that GATA6 is not essential for endoderm specification, but is required for normal branching morphogenesis and late epithelial cell differentiation...
  55. ncbi Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain
    S Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 128:527-40. 2001
    ..Furthermore, it appears that a Shh-independent pathway for generating oligodendrocytes exists...
  56. ncbi Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
    N Tekki-Kessaris
    Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6AE, UK
    Development 128:2545-54. 2001
    ..Overall, the data are consistent with the idea that OLPs in the telencephalon, possibly even some of those in the cortex, develop under the influence of SHH in the ventral forebrain...
  57. pmc Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
    Heiko Krude
    Department of Pediatric Endocrinology, Otto Heubner Center for Pediatrics, Berlin, Germany
    J Clin Invest 109:475-80. 2002
    ..Moreover, the association of symptoms in the patients with NKX2-1 mutations points to an important role of human NKX2-1 in the development and function of thyroid, basal ganglia, and lung, as already described for rodents...
  58. ncbi Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling
    Murielle Rallu
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York 10016, USA
    Development 129:4963-74. 2002
    ..In addition these results support the idea that, in addition to hedgehog signaling, a Shh-independent pathways must act during development to pattern the telencephalon...
  59. ncbi The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 5:1279-87. 2002
    ..Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE...
  60. ncbi Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 251:320-32. 2002
    ..Together, our data reveal that GLI3 limits Fgf8-expression domains in multiple tissues, through a mechanism that may include the induction or maintenance of apoptosis...
  61. ncbi Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis
    Paul R Reynolds
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 227:227-37. 2003
    ..TTF-1 regulates expression of MK in the lung. The temporal/spatial distribution of midkine is consistent with a potential role in paracrine signaling during lung morphogenesis...
  62. ncbi TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
    Mario DeFelice
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    J Biol Chem 278:35574-83. 2003
    ..In contrast to Titf1 null mutant mice, which lack peripheral lung tissues, bronchiolar and peripheral acinar components of the lung ..
  63. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain...
  64. ncbi Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
    Robert Machold
    Developmental Genetics Program and Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Neuron 39:937-50. 2003
    ..These results suggest that hedgehog signaling is required to maintain progenitor cells in the postnatal telencephalon...
  65. pmc Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse
    Henrik Fagman
    Institute of Anatomy and Cell Biology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Pathol 164:1865-72. 2004
    ..This study provides clues to the molecular mechanisms that might be dysregulated in thyroid hemiagenesis and development of ectopic thyroid tissue outside the thyroglossal duct...
  66. ncbi The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons
    Tetsuji Mori
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
    Eur J Neurosci 19:3129-41. 2004
    ..Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs...
  67. ncbi Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Dev Biol 273:402-15. 2004
    ..the lung field to maintain lung cell identity in the endoderm; RAR antagonism disrupts expression of thyroid transcription factor 1 (Ttf1), an early marker of the respiratory region in the endoderm, and surfactant protein C (Sp-C) ..
  68. ncbi Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB
    Lawrence S Prince
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Am J Physiol Lung Cell Mol Physiol 287:L999-1006. 2004
    ..These data implicate an important signaling mechanism in chorioamnionitis and suggest the TLR4/NF-kappaB pathway can influence lung development...
  69. ncbi An integrated regulatory network controlling survival and migration in thyroid organogenesis
    Rosanna Parlato
    Stazione Zoologica Anton Dohrn, Naples, Italy
    Dev Biol 276:464-75. 2004
    ..The experiments reported here analyze the expression of the transcription factors Titf1, Hhex, Pax8, and Foxe1 in the thyroid primordium of null mutants of each of them...
  70. ncbi Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development
    Paul R Reynolds
    Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    J Biol Chem 280:32548-54. 2005
    ..A model is also supported whereby alpha(7) is induced by the essential pulmonary transcription factor TTF-1 and suppressed by Egr-1 during pulmonary development...
  71. ncbi A mouse model demonstrates a multigenic origin of congenital hypothyroidism
    Elena Amendola
    Stazione Zoologica A Dohrn, Laboratorio di Genetica Animale at CEINGE, Naples, Italy
    Endocrinology 146:5038-47. 2005
    ..5% of cases, it can be a consequence of mutations in genes encoding the TSH receptor or the transcription factors TITF1, FOXE1, or PAX8...
  72. ncbi Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 132:4987-98. 2005
    ..These results combine in vitro and ex vivo analyses to link embryonic abnormalities in Shh signaling to postnatal alterations in cortical interneuron composition...
  73. pmc Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid
    Takashi Kusakabe
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 235:1300-9. 2006
    ..1 expression. These results demonstrate that T/ebp/Nkx2.1 plays a role in the survival of UBB cells, their dissemination into the thyroid diverticulum, and the formation of UBB-derived vesicular structure...
  74. ncbi Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos
    Nuria Moreno-Barriuso
    Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    Dev Dyn 235:2040-50. 2006
    ..The differentiation of type I cells barely occurred and capillaries remained in the abundant mesenchyme. These results indicate that LIF collaborates with IGF-I in lung alveolar epithelium and vascular maturation...
  75. ncbi FGF signalling generates ventral telencephalic cells independently of SHH
    Grigoriy Gutin
    Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Development 133:2937-46. 2006
    ..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types...
  76. ncbi Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Differentiation 74:422-37. 2006
    ..Future research must determine how Noggin/Bmp antagonism fits into the network of other factors known to regulate tracheal and esophagus development, both in mouse or humans...
  77. ncbi Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system
    Rosalind S E Carney
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 26:11562-74. 2006
    ..We further demonstrate that the generation of the LCS is dependent on the homeodomain-containing gene Gsh2, revealing a novel requirement for Gsh2 in telencephalic development...
  78. ncbi GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo
    Yuzhen Zhang
    Department of Medicine and University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 134:189-98. 2007
    ..However, the relevance of this synergy has not been demonstrated in vivo. We show that Gata6-Titf1 (Gata6-Nkx2...
  79. pmc Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells
    Parviz Minoo
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:2155-65. 2007
    ..These findings suggest a novel mode of selective gene regulation by proximo-distal gradient distribution of and functional interactions between forkhead and homeodomain transcription factors...
  80. ncbi Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia
    Yina Li
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Dyn 236:746-54. 2007
    ..Notably, ablating Bmp7 function in Nog(-/-) embryos rescued EA/TEF and notochord branching defects, establishing a critical role of Noggin-mediated Bmp7 antagonism in EA/TEF pathogenesis...
  81. pmc The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
    Benjamin L Allen
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 21:1244-57. 2007
    ....
  82. pmc Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:2521-31. 2007
    ..By contrast, Nkx2.1 (Titf1) is expressed ventrally, in the future trachea...
  83. ncbi Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors
    Goichi Miyoshi
    Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:7786-98. 2007
    ..We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation...
  84. ncbi Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex
    Matthew Fogarty
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6AE, United Kingdom
    J Neurosci 27:10935-46. 2007
    ....
  85. ncbi Fate mapping Nkx2.1-lineage cells in the mouse telencephalon
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 506:16-29. 2008
    ..1-expressing regions. In this paper, we present fate-mapping data on Nkx2.1-lineage neurons throughout the telencephalon, including the cerebral cortex, amygdala, olfactory bulb, striatum, globus pallidus, septum, and nucleus basalis...
  86. ncbi NF-kB induces lung maturation during mouse lung morphogenesis
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Dev Dyn 237:328-38. 2008
    ..These findings are consistent with a model whereby NF-kB may induce maturation of lung development through decreased apoptosis of epithelial cells...
  87. doi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
    ..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
  88. pmc The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
    Simon J B Butt
    Smilow Neuroscience Program and the Department of Cell Biology, New York University, New York, NY 10016, USA
    Neuron 59:722-32. 2008
    ..Our strategy reveals a causal link between the embryonic genetic specification by Nkx2-1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system...
  89. pmc Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Neuron 59:733-45. 2008
    ..Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells...
  90. doi FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Dev Dyn 238:503-13. 2009
    ..Thus, the separation, migration, and survival of the pharyngeal organs were impaired in the FRS2alpha(2F/2F) mutants...
  91. pmc Early thyroid development requires a Tbx1-Fgf8 pathway
    Gabriella Lania
    Telethon Institute of Genetics and Medicine, and University Federico II, Naples, Italy
    Dev Biol 328:109-17. 2009
    ..Thus, we have established that a Tbx1->Fgf8 pathway in the pharyngeal mesoderm is a key size regulator of mammalian thyroid...
  92. pmc Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
    Caterina Tiozzo
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine
    Am J Respir Crit Care Med 180:701-12. 2009
    ..In mouse, Pten expression is ubiquitous and begins as early as 7 days of gestation. Pten(-/-) mouse embryos die early during gestation indicating a critical role for Pten in embryonic development...
  93. doi The embryonic preoptic area is a novel source of cortical GABAergic interneurons
    Diego M Gelman
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 29:9380-9. 2009
    ....
  94. doi Patterning of ventral telencephalon requires positive function of Gli transcription factors
    Weiying Yu
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 334:264-75. 2009
    ..Together, these studies unravel a role for Gli transcription factors in mediating Shh signaling to control specification, differentiation and positioning of ventral telencephalic neurons...
  95. pmc Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 17:290-8. 2009
    ..Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut...
  96. pmc Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice
    Cindy L Yee
    Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, Genetics and Development, San Francisco, California 94158 2611, USA
    J Comp Neurol 517:37-50. 2009
    ..These results have implications for the genetic control of arcuate development and function and for the utility of the Nkx2.1-Cre and Dlx5/6i-Cre mouse lines to alter gene expression in the developing arcuate...
  97. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm...
  98. doi Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage
    Jinhyung Park
    Department of Surgery, Hospital for Sick Children, Toronto, Canada
    Dev Dyn 239:514-26. 2010
    ..These results indicate that Shh signalling is a critical determinant in tracheal cartilage development...
  99. doi Origin and molecular specification of globus pallidus neurons
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Sant Joan d Alacant, Spain
    J Neurosci 30:2824-34. 2010
    ....
  100. pmc Boc modifies the holoprosencephaly spectrum of Cdo mutant mice
    Wei Zhang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dis Model Mech 4:368-80. 2011
    ....
  101. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011
    ....

Research Grants8

  1. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  2. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
    ..1. ..
  3. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  5. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  6. Role of NFI in type II Cell Function
    CINDY BACHURSKI; Fiscal Year: 2006
    ..b>Thyroid transcription factor 1 (TTF1) and GATA6 have been implicated in differentiation of the distal pulmonary epithelium and we ..
  7. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  8. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..