Genomes and Genes
Gene Symbol: Nkx1-2
Description: NK1 transcription factor related, locus 2 (Drosophila)
Alias: Nkx-1.1, Nkx-1.2, Sax1, NK1 transcription factor-related protein 2, homeobox protein Nkx1.2E427, homeobox protein SAX-1, spinal cord axial homeobox gene 1
- Expression of the novel murine homeobox gene Sax-1 in the developing nervous systemF R Schubert
Abteilung für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
Mech Dev 51:99-114. 1995..0 pc. Ventral shift and finally loss of the signal in the ventral spinal cord was observed in Danforth's short tail homozygotes...
- Regulation of cell protrusions by small GTPases during fusion of the neural foldsAna Rolo
Newlife Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom
elife 5:e13273. 2016..This study provides evidence for the essential role and molecular regulation of membrane protrusions prior to fusion of a key organ primordium in mammalian development. ..
- Oct4 Is a Key Regulator of Vertebrate Trunk Length DiversityRita Aires
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Dev Cell 38:262-74. 2016....
- Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitorsThomas J Cunningham
Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
Biol Open 5:1821-1833. 2016..These findings provide evidence for early instructive and permissive roles of RA in controlling differentiation of NMPs to neural and mesodermal lineages...
- The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm developmentS J Tang
Department of Genetics, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
Development 125:1877-87. 1998..Similar to BMP4 and ALK3 mutants, the mutant embryos display severe defects in primitive streak and mesoderm formation. These experiments thus define a BMP/Tlx-2 signalling pathway that is required during early mammalian gastrulation...
- The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sitesA C Rovescalli
Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:1982-7. 2000..Nkx-1.2 mRNA was found in embryos in highest abundance in 10-day embryos; the mRNA levels decrease during further development. Nkx-1.2 mRNA also was found in discrete zones of the embryonic mesencephalon and myelencephalon...
- Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cellDana Ann A Tamashiro
Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A Burns School of Medicine, 651 Ilalo Street, Biosciences Building, Room 163A, Honolulu, Hawaii 96813, USA
Differentiation 83:282-92. 2012..These results suggest that Nkx1-2 is a critical component of the gene regulatory network that operates downstream of Wnt/β-catenin signaling to regulate the formation of mesendoderm...
- Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cellsMakiko Iwafuchi-Doi
Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
Development 139:3926-37. 2012..The direct interaction of these factors with enhancers of Otx2, Hesx1 and Sox2 genes was demonstrated. Thus, a combination of regulatory processes that suppresses non-ANP lineages and promotes neural plate development determines the ANP...
- Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafnessAnnalisa Buniello
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
PLoS ONE 8:e56274. 2013..Therefore, we propose that headbobber is a useful model to gain insight into the mechanisms underlying deafness in human 10qter deletion syndrome...
- Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterningA Gavalas
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
Development 124:3693-702. 1997..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres...
- Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factorsY H Kim
Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 273:25875-9. 1998..Thus, HIPKs represent a heretofore undescribed family of co-repressors for homeodomain transcription factors...
- Identification of tooth-specific downstream targets of Runx2J S Gaikwad
Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
Gene 279:91-7. 2001..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development...
- Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulationRuth Simon
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Mol Cell Biol 23:9046-60. 2003..uncharacterized murine homeobox gene, Sax2, that shows high similarity to the Drosophila S59/slouch and murine Sax1 genes...
- Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout miceE Catalani
Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
Neuroscience 138:487-99. 2006..The observations in neurokinin 1 receptor knockout mice may not be applicable to rats or rabbits, and substance P and neurokinin 1 receptor may play different developmental roles in different species...
- Laminar organization of the early developing anterior hypothalamusAurore Caqueret
Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
Dev Biol 298:95-106. 2006..We examined the expression pattern of 10 of the identified genes--Cart, Cbln1, Alcam, Unc-13c, Rgs4, Lnx4, Irx3, Sax1, Ldb2 and Neurod6--by in situ hybridization in E12.5 embryos...
- Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tubeRebecca Lee Yean Wong
Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
Hum Mol Genet 17:587-601. 2008..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...