Nkx1-2

Summary

Gene Symbol: Nkx1-2
Description: NK1 transcription factor related, locus 2 (Drosophila)
Alias: Nkx-1.1, Nkx-1.2, Sax1, NK1 transcription factor-related protein 2, homeobox protein Nkx1.2E427, homeobox protein SAX-1, spinal cord axial homeobox gene 1
Species: mouse

Top Publications

  1. ncbi Expression of the novel murine homeobox gene Sax-1 in the developing nervous system
    F R Schubert
    Abteilung für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 51:99-114. 1995
  2. pmc Regulation of cell protrusions by small GTPases during fusion of the neural folds
    Ana Rolo
    Newlife Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom
    elife 5:e13273. 2016
  3. doi Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
    Rita Aires
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Dev Cell 38:262-74. 2016
  4. pmc Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors
    Thomas J Cunningham
    Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
    Biol Open 5:1821-1833. 2016
  5. ncbi The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
    S J Tang
    Department of Genetics, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
    Development 125:1877-87. 1998
  6. pmc The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites
    A C Rovescalli
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1982-7. 2000
  7. pmc Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell
    Dana Ann A Tamashiro
    Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A Burns School of Medicine, 651 Ilalo Street, Biosciences Building, Room 163A, Honolulu, Hawaii 96813, USA
    Differentiation 83:282-92. 2012
  8. doi Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells
    Makiko Iwafuchi-Doi
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 139:3926-37. 2012
  9. pmc Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness
    Annalisa Buniello
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e56274. 2013
  10. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997

Scientific Experts

  • Rebecca Lee Yean Wong
  • Thomas J Cunningham
  • Rita Aires
  • Ana Rolo
  • Annalisa Buniello
  • Dana Ann A Tamashiro
  • Makiko Iwafuchi-Doi
  • Aurore Caqueret
  • E Catalani
  • Gregg Duester
  • Hannah E J Armer
  • Arnon D Jurberg
  • Dawn Savery
  • Moises Mallo
  • Nicholas D E Greene
  • Matteo A Molè
  • Andrew J Copp
  • Peter M G Munro
  • Alexandre Colas
  • Sarah Escuin
  • Ruth Simon
  • Francisca Leal
  • Martin J Cohn
  • Ana Novoa
  • Sandra C de Castro
  • Richard J Smith
  • Karen P Steel
  • Eva Bober
  • Rachel E Hardisty-Hughes
  • Johanna C Pass
  • Yusuke Marikawa
  • Hitoshi Niwa
  • Paul J Tesar
  • Hisato Kondoh
  • Kazuhiro Murakami
  • Isao Matsuo
  • Jun Aruga
  • Kazunari Matsuda
  • Vernadeth B Alarcon
  • J S Gaikwad
  • A C Rovescalli
  • G Casini
  • M Dal Monte
  • S J Tang
  • S Fineschi
  • Jacques L Michaud
  • L Bosco
  • Y H Kim
  • Francine Boucher
  • P Bagnoli
  • C Gangitano
  • M Lucattelli
  • A Gavalas
  • Thomas Lufkin
  • R N D'Souza
  • A Cavender
  • J Ferrante
  • F R Schubert
  • M Nirenberg
  • C A Kozak
  • M Cinquanta
  • M L Breitman
  • M A Conti
  • Y Kim
  • C Y Choi
  • J L Wrana
  • R R McInnes
  • Z Lu
  • S J Lee
  • P A Hoodless
  • M Buchwald
  • F M Rijli
  • P Chambon
  • M Davenne
  • A Lumsden
  • A Fainsod
  • Y Gruenbaum
  • P Gruss

Detail Information

Publications16

  1. ncbi Expression of the novel murine homeobox gene Sax-1 in the developing nervous system
    F R Schubert
    Abteilung für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 51:99-114. 1995
    ..0 pc. Ventral shift and finally loss of the signal in the ventral spinal cord was observed in Danforth's short tail homozygotes...
  2. pmc Regulation of cell protrusions by small GTPases during fusion of the neural folds
    Ana Rolo
    Newlife Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom
    elife 5:e13273. 2016
    ..This study provides evidence for the essential role and molecular regulation of membrane protrusions prior to fusion of a key organ primordium in mammalian development. ..
  3. doi Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
    Rita Aires
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Dev Cell 38:262-74. 2016
    ....
  4. pmc Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors
    Thomas J Cunningham
    Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
    Biol Open 5:1821-1833. 2016
    ..These findings provide evidence for early instructive and permissive roles of RA in controlling differentiation of NMPs to neural and mesodermal lineages...
  5. ncbi The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
    S J Tang
    Department of Genetics, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
    Development 125:1877-87. 1998
    ..Similar to BMP4 and ALK3 mutants, the mutant embryos display severe defects in primitive streak and mesoderm formation. These experiments thus define a BMP/Tlx-2 signalling pathway that is required during early mammalian gastrulation...
  6. pmc The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites
    A C Rovescalli
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1982-7. 2000
    ..Nkx-1.2 mRNA was found in embryos in highest abundance in 10-day embryos; the mRNA levels decrease during further development. Nkx-1.2 mRNA also was found in discrete zones of the embryonic mesencephalon and myelencephalon...
  7. pmc Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell
    Dana Ann A Tamashiro
    Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A Burns School of Medicine, 651 Ilalo Street, Biosciences Building, Room 163A, Honolulu, Hawaii 96813, USA
    Differentiation 83:282-92. 2012
    ..These results suggest that Nkx1-2 is a critical component of the gene regulatory network that operates downstream of Wnt/β-catenin signaling to regulate the formation of mesendoderm...
  8. doi Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells
    Makiko Iwafuchi-Doi
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 139:3926-37. 2012
    ..The direct interaction of these factors with enhancers of Otx2, Hesx1 and Sox2 genes was demonstrated. Thus, a combination of regulatory processes that suppresses non-ANP lineages and promotes neural plate development determines the ANP...
  9. pmc Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness
    Annalisa Buniello
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e56274. 2013
    ..Therefore, we propose that headbobber is a useful model to gain insight into the mechanisms underlying deafness in human 10qter deletion syndrome...
  10. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997
    ..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres...
  11. ncbi Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
    Y H Kim
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:25875-9. 1998
    ..Thus, HIPKs represent a heretofore undescribed family of co-repressors for homeodomain transcription factors...
  12. ncbi Identification of tooth-specific downstream targets of Runx2
    J S Gaikwad
    Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
    Gene 279:91-7. 2001
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development...
  13. pmc Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
    ..uncharacterized murine homeobox gene, Sax2, that shows high similarity to the Drosophila S59/slouch and murine Sax1 genes...
  14. ncbi Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice
    E Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
    Neuroscience 138:487-99. 2006
    ..The observations in neurokinin 1 receptor knockout mice may not be applicable to rats or rabbits, and substance P and neurokinin 1 receptor may play different developmental roles in different species...
  15. ncbi Laminar organization of the early developing anterior hypothalamus
    Aurore Caqueret
    Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Dev Biol 298:95-106. 2006
    ..We examined the expression pattern of 10 of the identified genes--Cart, Cbln1, Alcam, Unc-13c, Rgs4, Lnx4, Irx3, Sax1, Ldb2 and Neurod6--by in situ hybridization in E12.5 embryos...
  16. ncbi Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
    Rebecca Lee Yean Wong
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 17:587-601. 2008
    ..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...