Nfkb1

Summary

Gene Symbol: Nfkb1
Description: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Alias: NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105, nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, NF kappaB1, NF-kappa-B1 p84/NF-kappa-B1 p98, NF-kappaB p50, nuclear factor kappaB p50, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105, p50 subunit of NF kappaB
Species: mouse

Top Publications

  1. ncbi B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching
    C M Snapper
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 156:183-91. 1996
  2. ncbi Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
    Reinout Schauvliege
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 277:41624-30. 2002
  3. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
  4. ncbi Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
    Takayoshi Suganami
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Arterioscler Thromb Vasc Biol 27:84-91. 2007
  5. ncbi A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    J Das
    Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, 333 Cedar Street, LCI 105, New Haven, CT 06520, USA
    Nat Immunol 2:45-50. 2001
  6. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
  7. pmc NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    Shanjin Cao
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 281:26041-50. 2006
  8. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
  9. ncbi TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
    C D Dumitru
    Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Cell 103:1071-83. 2000
  10. pmc Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury
    Fiona Oakley
    Liver Group, Southampton General Hospital, Southampton SO16 6YD UK
    Am J Pathol 166:695-708. 2005

Detail Information

Publications201 found, 100 shown here

  1. ncbi B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching
    C M Snapper
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 156:183-91. 1996
    ..understand the role of NF-kappaB in normal B cell physiology, we used a purified population of resting B cells from p50/NF-kappa B knockout (p50-/-) mice to determine their ability to proliferate, secrete Ig, express germ-line CHRNA, ..
  2. ncbi Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
    Reinout Schauvliege
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 277:41624-30. 2002
    ..In the case of interferon-gamma stimulation, signal transducer and activator of transcription 1 binding to the caspase-11 promoter could be shown to be required for caspase-11 expression...
  3. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    Homodimers of the NF-kappa B p50 subunit are transcriptionally repressive in cells, whereas they can promote transcription in vitro, suggesting that their endogenous effects are mediated by association with other factors...
  4. ncbi Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
    Takayoshi Suganami
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Arterioscler Thromb Vasc Biol 27:84-91. 2007
    ....
  5. ncbi A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    J Das
    Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, 333 Cedar Street, LCI 105, New Haven, CT 06520, USA
    Nat Immunol 2:45-50. 2001
    ..Mice that lack the p50 subunit of nuclear factor kappa B (NF-kappa B) are unable to mount airway eosinophilic inflammation...
  6. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
    ..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression...
  7. pmc NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    Shanjin Cao
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 281:26041-50. 2006
    ..We identified a role for a single NF-kappaB family member, NF-kappaB1 (p50), in promoting the transcription of IL-10...
  8. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
    ..These results have implications for the treatment of inflammatory and proliferative diseases...
  9. ncbi TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
    C D Dumitru
    Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Cell 103:1071-83. 2000
    ..Subcellular fractionation of LPS-stimulated macrophages revealed that LPS signals transduced by Tpl2 specifically promote the transport of TNF-alpha mRNA from the nucleus to the cytoplasm...
  10. pmc Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury
    Fiona Oakley
    Liver Group, Southampton General Hospital, Southampton SO16 6YD UK
    Am J Pathol 166:695-708. 2005
    In this study we addressed the role of the nuclear factor (NF)-kappaB1/p50 subunit in chronic injury of the liver by determining the inflammatory and fibrotic responses of nfkappab1-null mice in an experimental model that mimics chronic ..
  11. pmc Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia
    Guang Yang
    Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Clin Invest 114:669-78. 2004
    ..Furthermore, neonatal p50-null mutant (p50(-/-)) mice showed increased lung DNA degradation and decreased survival in hyperoxia compared with ..
  12. doi Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ
    Eve Draper
    Immunomodulation Research Group, School of Biotechnology, Dublin City University, Dublin 9, Ireland
    J Nutr Biochem 22:784-90. 2011
    ..Thus n-3 PUFA activate PPARγ and interact with NF-κB in DC. However, the anti-inflammatory effects of EPA and DHA on DCs are independent of PPARγ...
  13. pmc The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
    Christine S Cheng
    Signaling Systems Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Sci Signal 4:ra11. 2011
    ..Combining top-down and bottom-up systems biology approaches, we have identified the NF-κB p50 homodimer as a regulator of IRF responses...
  14. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  15. doi Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice
    Suzanne Denis-Donini
    Department of Biology, Section of Zoology and Cytology, University of Milan and Neuroscience Institute, National Research Council, Milan 20100, Italy
    J Neurosci 28:3911-9. 2008
    ..We have studied hippocampal neurogenesis in NF-kappaB p50-deficient mice...
  16. ncbi NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase
    Michael R Waterfield
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mol Cell 11:685-94. 2003
    ..Here we demonstrate another function of NF-kappaB, in which the nfkappab1 gene product p105 regulates MAP kinase signaling triggered by the bacterial component lipopolysaccharide...
  17. ncbi Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning
    C A Kassed
    Department of Pharmacology and Therapeutics, University of South Florida, Tampa 33612, USA
    Exp Neurol 176:277-88. 2002
    ..by the limbic-specific neurotoxicant trimethyltin (TMT) as a model in which to examine activation of the NF-kappaB p50 subunit before, during, and after neuronal degeneration...
  18. pmc Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity
    Andrew H Coles
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 107:11423-8. 2010
    ....
  19. pmc Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice
    Yanhua Liang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    J Invest Dermatol 131:141-9. 2011
    ..These results indicate that absence of SHARPIN causes IHES with eosinophilic dermatitis by NF-κB activation, and bortezomib may be an effective treatment for skin problems of IHES...
  20. pmc Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells
    Young Jung Lee
    College of Pharmacy, Chungbuk National University, 12 Gaesin Dong, Heungduk gu, Cheongju, Chungbuk 361 763, Korea
    J Neuroinflammation 8:132. 2011
    ....
  21. pmc Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
    Manabu Minami
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 283:9692-703. 2008
    ..that PGE(2) pretreatment selectively inhibits lipopolysaccharide (LPS)-induced nuclear factor kappaB1 (NF-kappaB1) p105 phosphorylation and degradation in mouse bone marrow-derived macrophages through EP4-dependent mechanisms...
  22. pmc Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase
    Sanjukta Ghosh
    Department of Microbiology, Bose Institute, Calcutta 700 054, India
    Infect Immun 70:6828-38. 2002
    ..Hence, the induction of ceramide synthesis in host macrophages appears to be instrumental and one of the turning points leading to silencing of the macrophage antileishmanial responses...
  23. ncbi Gliotoxin reduces the severity of trinitrobenzene sulfonic acid-induced colitis in mice: evidence of the connection between heme oxygenase-1 and the nuclear factor-kappaB pathway in vitro and in vivo
    Chang Duk Jun
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Inflamm Bowel Dis 12:619-29. 2006
    ..In this report, the authors investigated the mechanism whereby gliotoxin has anti-inflammatory properties in vitro and in trinitrobenzene sulfonic acid-induced colitis...
  24. pmc Induction of epidermal growth factor receptor expression by Epstein-Barr virus latent membrane protein 1 C-terminal-activating region 1 is mediated by NF-kappaB p50 homodimer/Bcl-3 complexes
    Natalie J Thornburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 81:12954-61. 2007
    ..Treatment with p105/p50 siRNA effectively reduced p105/p50 levels but unexpectedly increased Bcl-3 expression and levels of p50/Bcl-3 ..
  25. pmc X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression
    Jason R Neil
    Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Biol Chem 284:21209-17. 2009
    ..Collectively our findings have defined a novel role for xIAP in mediating oncogenic signaling by TGF-beta in breast cancer cells...
  26. doi NF-kappaB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells
    Paola Bendinelli
    Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, University of Milan, Milan, Italy
    Mol Cancer Res 7:1328-41. 2009
    ..and the enhanced c-Jun expression played a functional role in exacerbating the invasiveness of 1833 cells after p50/p65 transfection and of 4T1 cells exposed to transforming growth factor-beta1...
  27. pmc MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling
    Rebecca T Marquez
    University of Iowa School of Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 298:G535-41. 2010
    ..In conclusion, miR-21 expression was upregulated during early stages of liver regeneration. Targeting of Peli1 by miR-21 could potentially provide the basis for a negative feedback cycle regulating NF-kappaB signaling...
  28. pmc Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons
    Amit K Mitra
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Physiol Cell Physiol 299:C561-9. 2010
    ..a cell neuronal model. These data imply a positive feedback mechanism that may impact neuronal discharge sensitivity in response to ANG II...
  29. pmc Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Clin Invest 117:889-901. 2007
    ..Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD...
  30. ncbi Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis
    T S Finco
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Immunity 3:263-72. 1995
  31. ncbi The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4
    Wei Dong
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    J Biol Chem 281:26029-40. 2006
    ..We show that BCL10 oligomerization is a prerequisite for BCL10 function in LPS signaling to NF-kappaB and that IRAK-1 dimerization is an important event in this process...
  32. pmc Toll-like receptor 2-dependent NF-kappaB activation is involved in nontypeable Haemophilus influenzae-induced monocyte chemotactic protein 1 up-regulation in the spiral ligament fibrocytes of the inner ear
    Sung K Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Infect Immun 75:3361-72. 2007
    ..These results may provide us with new therapeutic strategies for prevention of inner ear dysfunction secondary to chronic middle ear inflammation...
  33. ncbi Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:7332-9. 2006
    ..The defect in response to IL-10-Ig appeared to be primarily the result of the absence of the p50/p105 subunit, because the ability of IL-10-Ig to inhibit colitis was also compromised in p50(-/-); RAG-2(-/-) (p50/RAG) ..
  34. ncbi Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 376:167-70. 1995
    NF-kappa B, which consists of two polypeptides, p50 (M(r) 50K) and p65/RelA (M(r) 65K), is thought to be a key regulator of genes involved in responses to infection, inflammation and stress...
  35. pmc Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities
    R J Grumont
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Proc Natl Acad Sci U S A 91:4367-71. 1994
    The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70 I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105...
  36. ncbi NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety
    Cheryl A Kassed
    Section on Functional Neuroanatomy, National Institute of Mental Health, NIH, DHHS, Bldg 36, Rm 2D15, Bethesda, MD 20892 4070, USA
    Behav Brain Res 154:577-84. 2004
    ..Recently, it has been found to be active in neurons, and mice lacking NF-kappaB subunits p50 or p65 show deficits in specific cognitive tasks...
  37. ncbi Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 176:1244-51. 2006
    ..species that induces lower bowel inflammation in susceptible mouse strains, including those lacking the p50/p105 subunit of NF-kappaB. H...
  38. ncbi NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
    ..Osteoclast formation induced by these cytokines requires NF-kappaB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors...
  39. doi Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages
    Yuejuan Zheng
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
    J Immunol 184:6447-56. 2010
    ..Therefore, Gab1 is needed for full activation of TLR3/4- and RIG-I-triggered innate responses by promoting activation of PI3K/Akt, MAPKs, and NF-kappaB pathways...
  40. pmc Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans
    Mathieu Ferron
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    Cell Metab 14:466-77. 2011
    ..This study defined Inpp4b as a major modulator of the osteoclast differentiation and as a gene linked to variability of bone mineral density in mice and humans...
  41. doi Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells
    Dilan Dissanayake
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    Nat Med 17:1663-7. 2011
    ..These findings provide a new perspective on functional DC maturation and a potential mechanism that may account for pathologic T cell activation...
  42. pmc Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins
    M Takeuchi
    Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Proc Natl Acad Sci U S A 92:3561-5. 1995
    ..These findings establish that, as with other endothelial cell adhesion molecules, transcriptional induction of MAdCAM-1 by TNF-alpha requires activated NF-kappa B proteins...
  43. ncbi p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Jan Bohuslav
    Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143 1234, USA
    J Biol Chem 279:26115-25. 2004
    ..These findings highlight a rather unusual pathway of NF-kappaB activation, which is utilized by the p53 tumor suppressor...
  44. ncbi De novo ICAM-1 synthesis in the mouse lung: model of assessment of protein expression in lungs
    Stephen M Vogel
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 291:L496-501. 2006
    ..Moreover, the general method presented herein has potential value in assessing mechanisms of gene and protein expression in the isolated-perfused mouse lung model...
  45. ncbi Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice
    Hong Liang Li
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Hypertension 49:1399-408. 2007
    ..In conclusion, our results suggest that MR-1 plays an aggravative role in the development of cardiac hypertrophy via activation of the nuclear factor kappaB signaling pathway...
  46. pmc Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism
    Zhenqiang Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 283:9917-24. 2008
    ..TNF could induce c-Fos expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss...
  47. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
    ..Collectively, our results suggest that while TRAF6 autoubiquitination may serve as a marker of activation, it is unlikely to underpin RING finger-dependent TRAF6 function...
  48. pmc Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation
    Vanesa Esteban
    Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
    PLoS ONE 4:e5406. 2009
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney...
  49. pmc Epstein-Barr virus latent membrane protein 1 modulates distinctive NF- kappaB pathways through C-terminus-activating region 1 to regulate epidermal growth factor receptor expression
    Che Pei Kung
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 84:6605-14. 2010
    ..EGFR) is highly induced by LMP1-CTAR1 in epithelial cells through activation of a novel NF-kappaB form containing p50 homodimers and Bcl-3...
  50. pmc Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation
    Sangwoon Chung
    Dept of Environmental Medicine, Univ of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 299:L192-203. 2010
    ....
  51. doi Vitamin D3 upregulated protein 1 suppresses TNF-α-induced NF-κB activation in hepatocarcinogenesis
    Hyo Jung Kwon
    Bio Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, South Korea
    J Immunol 185:3980-9. 2010
    ..These results indicate that VDUP1 negatively regulates hepatocarcinogenesis by suppressing TNF-α-induced NF-κB activation...
  52. pmc Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway
    Genevieve S Griffiths
    The Center for Cardiovascular Research and Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    J Biol Chem 286:14713-23. 2011
    ..Thus, we have elucidated an integrin-controlled pathway in which Bit-1 is, in part, responsible for the survival effects of cell-ECM interactions...
  53. doi Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β
    Eun Jin Chang
    College of Pharmacy, Seoul National University, Seoul, South Korea
    Mol Carcinog 50:310-7. 2011
    ..mouse skin with UVB (5 kJ/m(2) ) resulted in increased degradation of IκBα, nuclear translocation of p65 and p50, and the DNA binding of NF-κB...
  54. pmc p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6
    Bernat Baeza-Raja
    Center for Genomic Regulation, Program on Differentiation and Cancer, E 08003 Barcelona, Spain
    Mol Biol Cell 15:2013-26. 2004
    ..This study provides the first evidence of a crosstalk between p38 MAPK and NF-kappaB signaling pathways during myogenesis, with IL-6 being one of the effectors of this promyogenic mechanism...
  55. ncbi Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy
    Natsumi Kawamura
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Higashi ku, Fukuoka, Japan
    Cardiovasc Res 66:520-9. 2005
    ..In the present study, we assessed the hypothesis that cardiotoxic effects of proinflammatory cytokines are mediated by the activation of NF-kappaB...
  56. ncbi AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis
    Z Han
    Division of Rheumatology, UCSD School of Medicine, La Jolla, CA 92093 0656, USA
    Autoimmunity 28:197-208. 1998
    ..To determine the expression and regulation of nuclear transcription factors AP-1 and NF-kappaB in rheumatoid arthritis and in collagen-induced arthritis in mice...
  57. ncbi Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65
    ALISON M O'MAHONY
    Gladstone Institute for Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141, USA
    J Biol Chem 279:18137-45. 2004
    ..IKK2 plays a dominant role in signaling for IkappaBalpha degradation, whereas IKK1 appears to play an important role in enhancing the transcriptional activity of NF-kappaB by promoting RelA/p65 phosphorylation...
  58. pmc NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes
    Huating Wang
    Human Cancer Genetics Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 27:4374-87. 2007
    ..NF-kappaB regulation of YY1 occurred at the transcriptional level, mediated by direct binding of the p50/p65 heterodimer complex to the YY1 promoter...
  59. ncbi Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen
    F Weih
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Oncogene 9:3289-97. 1994
    ..and spleen extracts when compared to RelA, in both tissues the predominant kappa B-binding activity consists of p50/RelB and p52/RelB heterodimers and only very little binding of RelA-containing complexes to kappa B sites was ..
  60. pmc Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB
    R J Grumont
    Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Exp Med 191:1281-92. 2000
    ..This cross-regulation between two different signaling pathways represents a novel mechanism that Rel/nuclear factor kappaB can repress the transcription of IFN-regulated genes in a cell type-specific manner...
  61. ncbi Effect of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) on hepatocyte proliferation and apoptosis in mice deficient in the p50 subunit of the transcription factor NF-kappaB
    Zijing Lu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington 40536, USA
    Toxicol Sci 81:35-42. 2004
    ..and apoptosis after PCB administration was analyzed in wild-type mice and in mice deficient in the NF-kappaB p50 subunit (p50-/-). In a 2-day study, mice received a single intraperitoneal (ip) injection of corn oil or PCB-153...
  62. ncbi Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction
    Shunichi Kawano
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 291:H1337-44. 2006
    ..Knockout mice with targeted disruption of the p50 subunit of NF-kappaB (KO) were used to block the activation of NF-kappaB...
  63. ncbi Involvement of toll-like receptor 4 in the inflammatory reaction induced by hydroxyapatite particles
    Alexia Grandjean-Laquerriere
    INSERM, ERM 0203, IFR 53, 1 rue du Maréchal Juin, BP 138, 51095 Reims, Cedex, France
    Biomaterials 28:400-4. 2007
    ..All these results open future therapies to reduce the inflammatory response induced by HA biomaterials...
  64. pmc Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 283:10550-8. 2008
    ..Because CGN is a commonly used food additive in the Western diet, clarification of its effects and mechanisms of action are vital to issues of food safety...
  65. pmc RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B
    R P Ryseck
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Mol Cell Biol 12:674-84. 1992
    ..RelB does not bind with high affinity to NF-kappa B sites, but heterodimers between RelB and p50-NF-kappa B do bind to different NF-kappa B-binding sites with a similar affinity to that shown by p50-NF-kappa B ..
  66. ncbi Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal
    S Ghosh
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142
    Cell 62:1019-29. 1990
    The DNA binding subunit of the transcription factor NF-kappa B, p50, has been cloned. p50 appears to be synthesized as a larger protein that is then processed to its functional size...
  67. pmc Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50
    H Ishikawa
    Department of Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    J Exp Med 187:985-96. 1998
    ..p)50 molecule, a subunit of nuclear factor (NF)-kappaB, is produced after proteolytic processing of the p105 precursor (NF-kappaB1)...
  68. pmc Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis
    I K Campbell
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, and Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Clin Invest 105:1799-806. 2000
    ..To assess this, mice with null mutations in c-rel or nfkb1 were used to examine directly the roles of c-Rel and p50 in models of acute and chronic inflammatory arthritis...
  69. pmc The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
    Thomas Pohl
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 99:4514-9. 2002
    ..Embryonic development and the maturation of hemopoietic progenitors were unaffected in nfkb1(-/-)c-rel(-/-) mice...
  70. ncbi Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes
    Jan Schulze-Luehrmann
    Department of Molecular Pathology, Institute of Pathology, D 97080 Wuerzburg, Germany
    Blood 100:954-60. 2002
    ..These findings suggest that by inhibiting the antiapoptotic action of NF-kappaB and inducing the proapoptotic activity of JNK, OHPK1 supports apoptosis in T cells...
  71. ncbi RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100
    Emmanuel Derudder
    Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Institut Andre Lwoff, 7 rue Guy Moquet, 94801 Villejuif, France
    J Biol Chem 278:23278-84. 2003
    ..We demonstrate that LTbetaR ligation induces not only RelA/p50 dimers but also RelB/p50 dimers, whereas TNF-alpha induces only RelA/p50 dimers...
  72. ncbi Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 278:45145-53. 2003
    ..Furthermore, PARP-1 interacted directly with p300 and enhanced the interaction of NF-kappaB1/p50 to p300...
  73. pmc Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Exp Med 198:1265-76. 2003
    ..Thus, IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of IL-12 p35 transcription in synergy with LPS-mediated events...
  74. ncbi Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia
    David Martin-Oliva
    University Hospital, San Cecilio, Granada
    Oncogene 23:5275-83. 2004
    ....
  75. pmc Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
    Brian Zarnegar
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8108-13. 2004
    ..Here, we have compared the contribution of the type 1 (p50-dependent) and type 2 (p52-dependent) NF-kappaB activation pathways to cell survival, proliferation, homotypic ..
  76. pmc The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms
    Raffi Gugasyan
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:5733-45. 2004
    ....
  77. ncbi Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
    Nature 430:218-22. 2004
    ..Endogenous IkappaBzeta specifically associates with the p50 subunit of NF-kappaB, and is recruited to the NF-kappaB binding site of the IL-6 promoter on stimulation...
  78. ncbi IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS
    Jutta I Kollet
    Department of Oral Biology and the Nebraska Center for Virology, University of Nebraska Medical Center, Lincoln, NE 68583 0740, USA
    Mol Immunol 43:623-33. 2006
    LPS and IFN-gamma, which activate NF-kappaB cRel/p50 and IFN regulatory factor-1 (IRF-1), respectively, costimulate expression of the IL-12 p35 subunit in macrophages...
  79. ncbi Momordin I, an inhibitor of AP-1, suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival
    Yun Ha Hwang
    Department of Chemistry NS60, Seoul National University, Shinlim Dong san 56 1, Seoul 151 747, Republic of Korea
    Biochem Biophys Res Commun 337:815-23. 2005
    ..In conclusion, the present results demonstrate for the first time that momordin I is a potent inhibitor of osteoclast differentiation via the reduction of NF-kappaB and AP-1, and also suppresses osteoclast function and survival...
  80. pmc Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta
    Niki L Reynaert
    Department of Pathology and Chemistry, University of Vermont, Burlington, 05405, USA
    Proc Natl Acad Sci U S A 103:13086-91. 2006
    ..Collectively, these findings demonstrate the physiological relevance of the S-glutathionylation-GRX redox module in controlling the magnitude of activation of the NF-kappaB pathway...
  81. pmc Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 18:930-42. 2007
    ..We speculate that AEBP1 may serve as a potential therapeutic target for the treatment of various chronic inflammatory diseases and cancer...
  82. ncbi A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity
    Zhimin Peng
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 282:21487-96. 2007
    ....
  83. ncbi Structure of NF-kappa B p50 homodimer bound to a kappa B site
    G Ghosh
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06510
    Nature 373:303-10. 1995
    The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region folds into two distinct domains, similar to those in the immunoglobulin superfamily...
  84. ncbi Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 9:2736-46. 1995
    ..NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities...
  85. ncbi NF-kappa B: ten years after
    P A Baeuerle
    Tularik Inc, South San Francisco, California 94080, USA
    Cell 87:13-20. 1996
  86. pmc Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
    M Wu
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    EMBO J 15:4682-90. 1996
    ....
  87. ncbi Hyperoxia activates NF-kappaB and increases TNF-alpha and IFN-gamma gene expression in mouse pulmonary lymphocytes
    L M Shea
    Pediatric Critical Care, The Children s Hospital, Denver, CO 80218, USA
    J Immunol 157:3902-8. 1996
    ....
  88. ncbi Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent
    F Weih
    Department of Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA
    J Immunol 157:3974-9. 1996
    ..We also generated mutant mice deficient in both RelB and the p50 subunit of NF-kappaB (p50(kappaO), multiple defects in B cell function)...
  89. ncbi Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
    V Iotsova
    Department of Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    Nat Med 3:1285-9. 1997
    The nfkb1 and nfkb2 genes encode closely related products regulating immune and inflammatory responses. Their role during development and differentiation remains unclear...
  90. ncbi Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
    F E Chen
    Department of Biology, University of California, San Diego, La Jolla 92093 0359, USA
    Nature 391:410-3. 1998
    The NF-kappaB p50/p65 heterodimer is the classical member of the Rel family of transcription factors which regulate diverse cellular functions such as immune response, cell growth, and development...
  91. pmc B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
    R J Grumont
    The Walter and Eliza Hall Institute of Medical Research, Post Office The Royal Melbourne Hospital, Victoria 3050, Australia
    J Exp Med 187:663-74. 1998
    ..Consistent with an increased rate of mature B cell turnover in naive nfkb1-/- mice, the level of apoptosis in cultures of quiescent nfkb1-/-, but not c-rel-/-, B cells is higher...
  92. ncbi NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    S Ghosh
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 16:225-60. 1998
    ..In this review, we discuss some of these recent findings and their implications for the study of NF-kappa B...
  93. pmc Regulation of an essential innate immune response by the p50 subunit of NF-kappaB
    J Bohuslav
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 102:1645-52. 1998
    ..deletions of the proteins of NF-kappaB complex, we provide data demonstrating that increased expression of the p50 subunit of NF-kappaB directly results in the downregulation of LPS-induced TNF production...
  94. ncbi The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation
    T Huxford
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0359, USA
    Cell 95:759-70. 1998
    ..The 2.3 A crystal structure of IkappaBalpha in complex with the NF-kappaB p50/p65 heterodimer reveals mechanisms of these inhibitory activities...
  95. pmc Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
    B N Cronstein
    New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:6377-81. 1999
    ..in the generic murine air-pouch model by using wild-type mice and mice rendered deficient in either COX-2 or p105, the precursor of p50, one of the components of the multimeric transcription factor NFkappaB...
  96. pmc Nuclear factor kappa B is required for the development of marginal zone B lymphocytes
    A Cariappa
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 192:1175-82. 2000
    ..Reconstitution of B cells in Rag-2(-/-) mice with a mixture of p50(-/-)/p65(-/-) fetal liver cells and Rag-2(-/-) bone marrow cells revealed that the generation of marginal zone B ..
  97. pmc NF-kappaB: a key role in inflammatory diseases
    P P Tak
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Invest 107:7-11. 2001
  98. ncbi The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site
    Benjamin Berkowitz
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA
    J Biol Chem 277:24694-700. 2002
    We have determined the x-ray crystal structure of the transcription factor NF-kappaB p50.p65 heterodimer complexed to kappaB DNA from the cytokine interferon beta enhancer (IFNbeta-kappaB)...
  99. ncbi Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3
    Stephan Paxian
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    Gastroenterology 122:1853-68. 2002
    ..Targeted disruption of these genes showed essential roles in lymphoid organ development and organization...
  100. ncbi Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein
    Sung Hee Baek
    Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA
    Cell 110:55-67. 2002
    ....
  101. ncbi The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation
    Alexander Hoffmann
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 298:1241-5. 2002
    ..Bimodal signal-processing characteristics with respect to stimulus duration are revealed by the model and are shown to generate specificity in gene expression...

Research Grants18

  1. Dietary Antioxidants, NF-KappaBeta, and Carcinogenesis
    HOWARD GLAUERT; Fiscal Year: 2002
    ..The development of a knockout mouse model that is deficient in the p50 subunit of NF-kB will allow the investigators to answer this question...
  2. Epithelial Dysfunction in Early IPF
    TIMOTHY BLACKWELL; Fiscal Year: 2009
    ..By elucidating the critical components of early stage disease, our study will define novel targets for future therapeutic interventions. ..
  3. REGULATION OF EBV TRANSCRIPTION IN BURKITT'S LYMPHOMA
    SAMUEL SPECK; Fiscal Year: 2009
    ....
  4. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  5. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  6. Prevention of Cigarette Smoke-Induced Lung Cancer by Dietary Selenium
    HOWARD GLAUERT; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
    ..abstract_text> ..
  8. Subversion of innate immune responses by Brucella
    Sankar Ghosh; Fiscal Year: 2006
    ..We are therefore proposing to characterize the role of TIRB in Brucella infection and we believe that our studies will help in the future development of therapeutic strategies, including vaccination, against human infection by Brucella. ..
  9. VIRAL TRANSCRIPTION IN EBV TRANSFORMED B CELLS
    SAMUEL SPECK; Fiscal Year: 2006
    ..Aim 4. Analysis of Wp methylation during the establishment and maintenance of immortalizing latency in B cells - role of methylation in regulating Wp activity in lymphoblastoid cell lines. ..
  10. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  11. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  12. NF-kappaB: Biology and Pathology
    Sankar Ghosh; Fiscal Year: 2004
    ..Students will greatly benefit from exposure to many different biological processes, diseases and scientific approaches. ..
  13. MOLECULAR REGULATION OF LUNG INFLAMMATION BY NF-KB
    TIMOTHY BLACKWELL; Fiscal Year: 2006
    ..abstract_text> ..
  14. ROLE OF NF-KB IN TGF-B1 INDUCED APOPTOSIS OF HEPATOCYTES
    Marcello Arsura; Fiscal Year: 2005
    ..Furthermore, these findings will provide important insights into the role of NF- kappaB/Rel factors in the control of apoptosis of normal and transformed hepatocytes of potential clinical relevance. ..
  15. Fibroblast Specific Protein 1 in Pulmonary Fibrosis
    TIMOTHY BLACKWELL; Fiscal Year: 2004
    ..abstract_text> ..
  16. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  17. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..