Nfatc1

Summary

Gene Symbol: Nfatc1
Description: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Alias: 2210017P03Rik, AI449492, AV076380, NF-ATc, NFAT2, NFATc, Nfatcb, nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFAT transcription complex cytosolic component, transcription factor NF-ATc
Species: mouse

Top Publications

  1. ncbi Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp
    X Li
    Howard Hughes Medical Institute, Stanford University Medical Center, CA 94305 5428
    Cytogenet Cell Genet 68:185-91. 1995
  2. ncbi The transcription factor NFAT4 is involved in the generation and survival of T cells
    M Oukka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 9:295-304. 1998
  3. ncbi NF-ATc isoforms are differentially expressed and regulated in murine T and mast cells
    M A Sherman
    Department of Experimental Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 162:2820-8. 1999
  4. ncbi The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells
    Jennifer L Brogdon
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:3825-32. 2002
  5. ncbi Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor
    Kabsun Kim
    Research Institute of Medical Sciences and Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak Dong 5, Dong Ku, Gwangju, Korea
    J Immunol 178:5588-94. 2007
  6. ncbi MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:15921-9. 2007
  7. ncbi Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis
    Yoonji Kim
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8549
    J Biol Chem 280:32905-13. 2005
  8. doi Novel extraneural role of neurite outgrowth inhibitor A: modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1
    Youngkyun Lee
    Department of Cell and Developmental Biology, School of Dentistry, Seoul National University, Seoul, Korea
    J Bone Miner Res 27:1043-54. 2012
  9. pmc Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype
    Richard W Tsika
    Department of Biochemistry, School of Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 283:36154-67. 2008
  10. doi Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression
    Abu Shadat Mohammod Noman
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Immunol Lett 131:166-9. 2010

Research Grants

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp
    X Li
    Howard Hughes Medical Institute, Stanford University Medical Center, CA 94305 5428
    Cytogenet Cell Genet 68:185-91. 1995
    ..capable of functioning as the pre-existing (p) and cytosolic (c) component of the NFAT transcription complex, NFATc of human and NFATp of murine origin (Northrop et al., 1994; McCaffrey et al., 1993b)...
  2. ncbi The transcription factor NFAT4 is involved in the generation and survival of T cells
    M Oukka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 9:295-304. 1998
    ..Here we report that NFAT4, in contrast to NFATp and NFATc, is preferentially expressed in DP thymocytes...
  3. ncbi NF-ATc isoforms are differentially expressed and regulated in murine T and mast cells
    M A Sherman
    Department of Experimental Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 162:2820-8. 1999
    ..These results demonstrate another level of regulation within the NF-AT family that can contribute to cell type-specific gene expression...
  4. ncbi The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells
    Jennifer L Brogdon
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:3825-32. 2002
    ..Furthermore, the strength of the TCR signal differentially affects the balance of NFATp and NFATc DNA binding activity, thereby regulating IL-4 transcription...
  5. ncbi Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor
    Kabsun Kim
    Research Institute of Medical Sciences and Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak Dong 5, Dong Ku, Gwangju, Korea
    J Immunol 178:5588-94. 2007
    ..monocyte/macrophage lineage cells attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis...
  6. ncbi MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:15921-9. 2007
    Transcription factors NFATc1, PU.1, and MITF collaborate to regulate specific genes in response to colony-stimulating factor-1 (CSF-1) and receptor activator of NF-kappaB ligand (RANKL) signaling during osteoclast differentiation...
  7. ncbi Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis
    Yoonji Kim
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8549
    J Biol Chem 280:32905-13. 2005
    ..signals required for RANKL-mediated activation of calcium signaling, which leads to the activation of NFATc1. However, it remains unknown whether the expression of immunoreceptors are under the control of NFATc1...
  8. doi Novel extraneural role of neurite outgrowth inhibitor A: modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1
    Youngkyun Lee
    Department of Cell and Developmental Biology, School of Dentistry, Seoul National University, Seoul, Korea
    J Bone Miner Res 27:1043-54. 2012
    ..RANKL stimulation of mouse bone marrow macrophages (BMMs) in a nuclear factor of activated T cell cytoplasmic 1 (NFATc1)-dependent manner...
  9. pmc Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype
    Richard W Tsika
    Department of Biochemistry, School of Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 283:36154-67. 2008
    ..overexpression resulted in an unexpected activation of GSK-3alpha/beta and decreased nuclear beta-catenin and NFATc1/c3 protein...
  10. doi Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression
    Abu Shadat Mohammod Noman
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Immunol Lett 131:166-9. 2010
    ..The expression of nuclear factor of activated T cell 1 (NFATc1) as the terminal transcription factor of osteoclast formation was prevented by RIZ1 siRNA...
  11. ncbi Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos: a possible mechanism for downregulation of osteoclastogenesis
    Saad Gad Kamel Mohamed
    Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 329:839-45. 2005
    ..Recently NFATc1, a transcription factor, has been shown to play critical roles in osteoclastogenesis...
  12. pmc Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling
    Askar Akimzhanov
    Institute of Pathology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Am J Pathol 172:215-24. 2008
    The nuclear factor of activated T cell 1 (Nfatc1) locus is a common insertion site for murine tumorigenic retroviruses, suggesting a role of transcription factor NFATc1 in lymphomagenesis...
  13. pmc NFATc1 regulates PD-1 expression upon T cell activation
    Kenneth J Oestreich
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 181:4832-9. 2008
    ..Furthermore, analysis of this region by chromatin immunoprecipitation assay revealed NFATc1 binding associated with gene activation in EL4 and primary CD8 T cells...
  14. ncbi NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity
    S N Ho
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305, USA
    J Biol Chem 270:19898-907. 1995
    ..the NFAT transcription complex as a result of the calcium-dependent nuclear translocation of cytosolic subunits, NFATc, and the Ras/protein kinase C-dependent induction of a nuclear subunit, NFATn...
  15. ncbi Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc
    S Pan
    Department of Molecular and Developmental Biology, University of Tokyo, Japan
    Biochem Biophys Res Commun 240:314-23. 1997
    ..Here we describe cloning and characterization of full-length cDNA encoding murine (m) NFATc which predicts that the protein has all the conserved structural motifs of NFAT family members, including the rel ..
  16. ncbi The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
    H Yoshida
    The Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Immunity 8:115-24. 1998
    ..These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response...
  17. ncbi Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
    A M Ranger
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 8:125-34. 1998
    ..Our data demonstrate that NF-ATc is essential for the optimal generation and function of mature T and B lineage cells, with an especially profound effect on IL-4-driven responses...
  18. ncbi Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
    J L de la Pompa
    The Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 392:182-6. 1998
    ....
  19. ncbi The transcription factor NF-ATc is essential for cardiac valve formation
    A M Ranger
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 392:186-90. 1998
    ..Our results indicate that NF-ATc may play a critical role in signal-transduction processes required for normal cardiac valve formation...
  20. ncbi Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart
    R Y Kim
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 235:449-66. 2001
    ..5 and 15.5 dpc due to cardiac insufficiency. These data provide the first genetic evidence that BMPs are involved in the formation of the cardiac cushions...
  21. ncbi Regulation of the murine Nfatc1 gene by NFATc2
    Bin Zhou
    Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 277:10704-11. 2002
    NFAT proteins play a key role in the inducible expression of cytokine genes in T lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the peripheral immune system...
  22. pmc Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription
    Hiromichi Wada
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Cell Biol 156:983-91. 2002
    ..Using immunoprecipitation Western blotting, we showed that NFATc1 interacted with GATA-6. Consistent with this, NFATc1 further potentiated GATA-6-activated Sm-MHC transcription...
  23. ncbi Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis
    Sergei Chuvpilo
    Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, D97080 Wuerzburg, Germany
    Immunity 16:881-95. 2002
    ..In these cells, the short isoform A of NFATc1 is induced to high levels due to the autoregulation of the NFATc1 promoter P1 by NFATs...
  24. pmc Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
    Benjamin J Wilkins
    Division of Molecular Cardiovascular Biology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati Ohio 45229 3039, USA
    Mol Cell Biol 22:7603-13. 2002
    ..NFATc3-null mice also demonstrated attenuated pressure overload- and angiotensin II-induced cardiac hypertrophy. These results provide genetic evidence that calcineurin-regulated responses require NFAT effectors in vivo...
  25. pmc Nf1 has an essential role in endothelial cells
    Aaron D Gitler
    Department of Medicine, Cardiology Division, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 33:75-9. 2003
    ..level of ras signaling in Nf1(-/-) endothelial cells and greater nuclear localization of the transcription factor Nfatc1. Inactivation of Nf1 in the neural crest does not cause cardiac defects but results in tumors of neural-crest ..
  26. ncbi Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    Hiroshi Takayanagi
    Department of Immunology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    Dev Cell 3:889-901. 2002
    ..We show here that RANKL selectively induces NFATc1 expression via these two pathways...
  27. ncbi Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness
    M Benjamin Hock
    Department of Pathology and Graduate Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:26695-703. 2003
    ..both conventional and novel protein kinase C (PKC) family members regulate endogenous mast cell NFAT activity, and NFAT2 TA. Overexpression of dominant active PKC (which has been implicated in immune receptor signaling) induces NFAT2...
  28. pmc Normal B-1a cell development requires B cell-intrinsic NFATc1 activity
    Robert Berland
    Department of Pathology and Graduate Program in Immunology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 100:13459-64. 2003
    ..Here we show that the B-1a compartment is normal in mice lacking NFATc2 but essentially absent in mice lacking NFATc1. Loss of NFATc1 affects both peritoneal and splenic B-1a cells...
  29. ncbi Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice
    Joe V Chakkalakal
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Hum Mol Genet 13:379-88. 2004
    ..Muscles from mdx/CnA* displayed increased nuclear localization of NFATc1 and a fiber type shift towards a slower phenotype...
  30. ncbi DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice
    Alexander W Lange
    Division of Molecular Cardiovascular Biology, Children s Medical Center Cincinnati ML 7020, Cincinnati, OH 45229, USA
    Dev Biol 266:346-60. 2004
    ..DSCR1(e4)/lacZ expression in the developing valve endocardium colocalizes with NFATc1 and, endocardial DSCR1(e4)/lacZ, is notably reduced or absent in NFATc1(-/-) embryos...
  31. ncbi Calcineurin B1 is essential for positive but not negative selection during thymocyte development
    Joel R Neilson
    Department of Microbiology and Immunology, Beckman Center, Room B211, Stanford, CA 94305, USA
    Immunity 20:255-66. 2004
    ....
  32. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..In Sox9-null mutants, endocardial cushions are markedly hypoplastic. In these mutants, Nfatc1 is ectopically expressed and no longer restricted to endothelial cells...
  33. ncbi Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes
    Teruhisa Kawamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ Res 94:1492-9. 2004
    ..We show here that p300 markedly potentiates the binding of NFATc1 to the bcl-2 NFAT element by interacting with NFATc1 in an E1A-dependent manner...
  34. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
    ..constructs of the cathepsin K gene promoter indicates that limited sets of the transcription factors such as NFATc1, PU...
  35. ncbi A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
    ..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis...
  36. ncbi Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway
    Sanjeev Puri
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Biol Chem 279:55455-64. 2004
    ....
  37. ncbi Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart
    Bin Zhou
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 132:1137-46. 2005
    b>Nfatc1 is an endocardial transcription factor required for development of cardiac valves...
  38. ncbi NFAT and Osterix cooperatively regulate bone formation
    Takako Koga
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Nat Med 11:880-5. 2005
    ..Among NFAT proteins, NFATc1 is crucial for the differentiation of bone-resorbing osteoclasts...
  39. ncbi Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis
    Kabsun Kim
    Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, 501 746, Korea
    J Biol Chem 280:35209-16. 2005
    ..During osteoclast differentiation, NFATc1 is further activated via calcium signaling when costimulatory receptors expressed on osteoclast precursors, such ..
  40. pmc Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    Masataka Asagiri
    Department of Cell Signaling, Tokyo Medical and Dental University, Japan
    J Exp Med 202:1261-9. 2005
    b>NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system...
  41. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
  42. ncbi NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
    ..lie within the critical region of human chromosome 21 and act synergistically to prevent nuclear occupancy of NFATc transcription factors, which are regulators of vertebrate development...
  43. ncbi NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K
    Alexander W Lange
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center ML 7020, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 292:407-17. 2006
    b>NFATc1 is necessary for remodeling endocardial cushions into mature heart valve leaflets and is also an essential effector of receptor activator of NFkappaB ligand (RANKL) signaling required for transcriptional activation of bone matrix ..
  44. ncbi Calcineurin/NFAT signaling in osteoblasts regulates bone mass
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Dev Cell 10:771-82. 2006
    ..Here, we show that mice expressing a constitutively nuclear NFATc1 variant (NFATc1(nuc)) in osteoblasts develop high bone mass...
  45. ncbi Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway
    Joachim D Meissner
    Department of Physiology, Hannover Medical School, Hannover, Germany
    J Cell Physiol 211:138-48. 2007
    ..Transient transfection assays demonstrated that the calcineurin/NFATc1 signaling pathway is essential for MyHCbeta promoter activation during transformation of C2C12 myotubes but is not ..
  46. ncbi Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
    Kojiro Sato
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Japan
    Nat Med 12:1410-6. 2006
    ..reduced CREB phosphorylation and downregulated the expression of c-Fos, which is required for the induction of NFATc1 (the master transcription factor for osteoclastogenesis) that is activated by receptor activator of NF-kappaB ..
  47. ncbi NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
    ..Osteoclast formation induced by these cytokines requires NF-kappaB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors...
  48. pmc NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP)
    Kabsun Kim
    National Research Laboratory for Regulation of Bone Metabolism and Disease, Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju 501 746, Korea
    Mol Endocrinol 22:176-85. 2008
    b>NFATc1 has been characterized as a master regulator of nuclear factor kappaB ligand-induced osteoclast differentiation...
  49. pmc NFATc1 balances quiescence and proliferation of skin stem cells
    Valerie Horsley
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 132:299-310. 2008
    ..How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP ..
  50. pmc Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    BMC Dev Biol 8:75. 2008
    ....
  51. pmc Alternative splicing and expression of human and mouse NFAT genes
    Hanna Vihma
    Department of Gene Technology, Tallinn University of Technology, Tallinn 19086, Estonia
    Genomics 92:279-91. 2008
    Four members of the nuclear factor of activated T cells (NFAT) family (NFATC1, NFATC2, NFATC3, and NFATC4) are Ca(2+)-regulated transcription factors that regulate several processes in vertebrates, including the development and function ..
  52. pmc Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter
    Stefan Klein-Hessling
    Department of Molecular Pathology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 283:31030-7. 2008
    ..protein-protein interactions involving the C-terminal Zn(2+)-finger of GATA-3 and the C-terminal region of the NFATc1 DNA binding domain...
  53. pmc Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis
    Jue Zhang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 W Holcombe Boulevard, Houston, TX 77030, USA
    Development 135:3611-22. 2008
    ..These results provide new insight into the signaling molecules downstream of FGF receptor tyrosine kinases in cardiac progenitors...
  54. pmc NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism
    Antonios O Aliprantis
    Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 118:3775-89. 2008
    ..disease, we generated a conditional knockout of the transcription factor nuclear factor of activated T cells c1 (Nfatc1)...
  55. pmc Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase
    Arnab Nayak
    Departments of Molecular Pathology and Neurology, Julius Maximilians University, 97080 Wuerzburg and Institute of Immunology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Biol Chem 284:10935-46. 2009
    ..In peripheral T-cells NFATc1 and -c2 are predominantly expressed...
  56. pmc NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation
    Min Kyung Choo
    Department of Pathology, University of Alabama at Birmingham, 813 Shelby Biomedical Research Building, 1825 University Boulevard, Birmingham, AL 35294, USA
    Bone 45:579-89. 2009
    ..To investigate the mechanism by which NFATc1 regulates osteoblast differentiation, we established an osteoblast cell line that overexpresses a constitutively ..
  57. pmc Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression
    Tingfang Yi
    Department of Molecular and Cellular Medicine, Texas A and M University Health Science Center, Institute of BioScience and Technology, Center for Cancer and Stem Cell Biology, Houston, Texas 77030, USA
    J Biol Chem 285:17811-20. 2010
    ..Using chromatin immunoprecipitation and luciferase assays, we demonstrate that Gpr54 regulates NFAT2- and Sp1-mediated Bmp7 transcription...
  58. pmc Calcineurin regulates innate antifungal immunity in neutrophils
    Matthew B Greenblatt
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 207:923-31. 2010
    ....
  59. pmc Activation of NFAT signaling in podocytes causes glomerulosclerosis
    Yinqiu Wang
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 21:1657-66. 2010
    ..Here, we generated mice that allow conditional induction of NFATc1. Mice with NFAT activation in nascent podocytes in utero developed proteinuria and glomerulosclerosis postnatally, ..
  60. pmc Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)
    Martin Vaeth
    Department of Molecular Pathology, Institute of Pathology, University of Wurzburg, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 108:2480-5. 2011
    ..High levels of ICER suppressed the induction of nuclear factor of activated T cell c1 (Nfatc1) gene in T cells whose inducible Nfatc1 P1 promoter bears two highly conserved cAMP-responsive elements to which ..
  61. pmc NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network
    Sankar Bhattacharyya
    Department of Molecular Pathology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Exp Med 208:823-39. 2011
    By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B cells upon B cell ..
  62. pmc Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation
    Bingruo Wu
    Department of Genetics, Albert Einstein College of Medicine of Yeshiva University, Price Center 420, 1301 Morris Park Ave, Bronx, NY 10461, USA
    Circ Res 109:183-92. 2011
    ..b>Nfatc1 (nuclear factor of activated T cells, cytoplasmic 1) is highly expressed in valve endocardial cells and is ..
  63. ncbi [Effect of the costimulatory molecules OX40-OX40 ligand interaction on the expression of NFATc1 in leukocytes of apolipoprotein E-deficient mice]
    Liang Jie Xu
    Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
    Zhonghua Xin Xue Guan Bing Za Zhi 39:526-30. 2011
    To investigate the effect of OX40/OX40L interaction on the nuclear factor of activated T cells c1 (NFATc1) in ApoE-/- mice.
  64. pmc Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells
    Martin Vaeth
    Department of Molecular Pathology, Institute of Pathology, Julius Maximilians University Würzburg, 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 109:16258-63. 2012
    ..This is specific for iTreg development, because frequency of nTreg remained unaltered in mice lacking NFAT1, NFAT2, or NFAT4 alone or in combination...
  65. pmc Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling
    Bingruo Wu
    Departments of Genetics, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 151:1083-96. 2012
    ..This information may help develop better cell therapies for coronary artery disease...
  66. doi An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development
    Amiya K Patra
    Department of Molecular Pathology, Institute of Pathology, University of Wurzburg, Wurzburg, Germany
    Nat Immunol 14:127-35. 2013
    ..Here we found that IL-7-Jak3 signals activated the transcription factor NFATc1 in DN thymocytes by phosphorylating Tyr371 in the regulatory region of NFATc1...
  67. doi NFATc1 induction in peripheral T and B lymphocytes
    Matthias Hock
    Department of Molecular Pathology, Institute of Pathology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Immunol 190:2345-53. 2013
    ..We have reported previously that the short isoform NFATc1/αA whose generation is induced by immune receptor stimulation supports the proliferation and inhibits the ..
  68. pmc The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
    Alexander Zaslavsky
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 121:3205-15. 2013
    ..b>NFATc1 and c2 isoforms are expressed in megakaryocytes...
  69. ncbi NFATc1 and NFATc2 together control both T and B cell activation and differentiation
    S L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Immunity 14:13-20. 2001
    ..To investigate further the two most prominent NFAT family members, NFATc1 and NFATc2, we generated mice bearing lymphoid systems devoid of both...
  70. ncbi Selective role of NFATc3 in positive selection of thymocytes
    Kirsten Canté-Barrett
    Departments of Developmental Biology and Pathology, Howard Hughes Medical Institute, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    J Immunol 179:103-10. 2007
    ..Expression of a nuclear (and constitutively active) NFATc1 even at subphysiological levels can rescue the transition of double-negative to double-positive thymocytes in RAG-..
  71. ncbi A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 179:1096-103. 2007
    T cell activation and differentiation is accompanied and mediated by transcriptional reprogramming. The NFATc1 transcription factor is strongly induced upon T cell activation and controls numerous genes involved in the T cell effector ..
  72. ncbi Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator
    Norihiro Ishida
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
    J Biol Chem 277:41147-56. 2002
    ..Among a group of 106 early inducible genes (within 2-5 h after RANKL stimulation), four genes including NFAT2 were identified as genes whose enhanced expressions were fairly correlated with an efficient induction of matured ..
  73. pmc Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival
    Li Chen
    Department of Stem Cell Engineering, Basic Research Laboratories, Texas Heart Institute, Houston, Texas, United States of America
    PLoS ONE 7:e31005. 2012
    ..The regulation of Hey2 expression by Ezh2 may be independent of Notch signaling activity. Our work defines an indispensible role of the chromatin remodeling factor Ezh2 in normal cardiovascular development...
  74. pmc Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein
    Yukiko Kuroda
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
    Mol Cell Biol 32:2954-63. 2012
    ..Activation of the transcription factor NFATc1 (nuclear factor of activated T cells c1) by the receptor activator of NF-κB ligand (RANKL) is critical for ..
  75. ncbi Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    Bin Wang
    Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 131:4477-87. 2004
    ..5 and are similar to those observed in other mouse models of congenital heart disease, including Sox4 and Nfatc1 null embryos...
  76. ncbi SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:693-706. 2004
    ..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation...
  77. pmc RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis
    Jin Gohda
    Division of Cellular and Molecular Biology, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Shirokane dai, Minato ku, Tokyo, Japan
    EMBO J 24:790-9. 2005
    ..we found that h40/mRK with a single TRAF6-binding site efficiently induced Ca2+ oscillation and expression of NFATc1, a master switch in osteoclastogenesis, whereas CD40 carrying a single TRAF6-binding site did not...
  78. ncbi A strategy for probing the function of noncoding RNAs finds a repressor of NFAT
    A T Willingham
    Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 309:1570-3. 2005
    ....
  79. pmc Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation
    Hyeonju Yeo
    Department of Pathology, University of Alabama at Birmingham, 813 Shelby Biomedical Research Building, 1825 University Boulevard, Birmingham, AL 35294, USA
    Bone 40:1502-16. 2007
    ..of varying concentrations of CsA on bone formation and osteoblast differentiation and elucidate the role of NFATc1 in this response. We show that low concentrations of CsA (<1 microM in vitro and 35...
  80. ncbi Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts
    Véronique Lejard
    INSERM U652 and Paris Descartes University, 75006 Paris, France
    J Biol Chem 282:17665-75. 2007
    ..Analysis of TSE1 showed that it contains a consensus binding site for NFATc transcription factors...
  81. pmc Mechanism of nuclear factor of activated T-cells mediated FasL expression in corticosterone -treated mouse Leydig tumor cells
    Wei Ran Chai
    Department of Biochemistry and Molecular Biology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    BMC Cell Biol 9:31. 2008
    ..It is not clear yet how NFAT is involved in CORT-induced up-regulation of FasL. The aim of the present study is to investigate the molecular mechanisms of NFAT-mediated FasL expression in CORT-treated Leydig cells...
  82. doi Calcineurin/NFAT pathway: a novel regulator of parturition
    Chisa Tabata
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan
    Am J Reprod Immunol 62:44-50. 2009
    ..However, we found OTR-deficient (OTRKO) mice are fertile and deliver at term without birth defects, thus alternative pathways inducing parturition can be hypothesized...
  83. doi Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation
    Insun Song
    National Research Laboratory for Regulation of Bone Metabolism and Disease, Medical Research Center for Gene Regulation, Brain Korea 21, Chonnam National University Medical School, 5 Hak dong, Dong Ku, Gwangju 501 746, Republic of Korea
    FEBS Lett 583:2435-40. 2009
    b>NFATc1 is a master regulator of RANKL-induced osteoclast differentiation and herein we investigate the regulatory mechanism of NFATc1 in osteoclast activation...
  84. pmc Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis
    Youngkyun Lee
    Department of Cell and Developmental Biology, BK21 Program and DRI, Seoul National University, 28 Yeongon dong, Chongno Gu, Seoul 110 749, Korea
    J Biol Chem 284:33343-51. 2009
    ..Whereas DYRK1A phosphorylated and inhibited the osteoclastogenic transcription factor NFATc1, forced expression of NFATc1 induced DYRK1A expression, suggesting a negative feedback loop...
  85. pmc Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc
    Philip Sohn
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham AL, USA
    BMC Dev Biol 10:29. 2010
    ..We also compared expression profiles in tissues from wild type and Tgfbr2 mutant mice as well as in sclerotome cultures treated with TGF-beta or BMP4...
  86. pmc Calcium/NFAT signalling promotes early nephrogenesis
    S F Burn
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Dev Biol 352:288-98. 2011
    ..We propose that the non-canonical Calcium/NFAT Wnt signalling pathway plays an important role in early mammalian renal development and is required for complete MET during nephrogenesis, potentially acting downstream of Wnt4...
  87. pmc Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
    Karen M Osorio
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 193:235-50. 2011
    ..Thus, a master regulator of hematopoiesis also controls HFSC emergence and maintenance via modulation of bidirectional cross talking between nascent stem cells and their niche...
  88. ncbi Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells
    Georges Nemer
    Laboratoire de developpement et differenciation cardiaques, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Quebec H2W 1R7
    Development 129:4045-55. 2002
    ..This, in turn, suggests that the GATA5 pathway may be relevant to early stages of valvuloseptal development, defects of which account for the majority of human birth malformations...
  89. pmc Regulation of mature T lymphocyte proliferation and differentiation by Par-4
    Maria Jose Lafuente
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:4689-98. 2003
    ..Consistent with previous data from knock outs of different JNKs, NFATc1 activation and IL-4 secretion were augmented in the Par-4-deficient CD4+ T cells, suggesting that the loss of Par-..
  90. pmc Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt
    Ingrid Remy
    Departement de Biochimie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Mol Cell Biol 24:1493-504. 2004
    ..The wide distribution of Ft1 in adult tissues suggests that it could be a general regulator of PKB activity in the control of differentiation, proliferation, and apoptosis in many cell types...
  91. ncbi Role of NFAT proteins in IL13 gene transcription in mast cells
    Silvia Monticelli
    Department of Pathology, Harvard Medical School, and CBR Institute for Biomedical Research, Boston, MA 02115, USA
    J Biol Chem 279:36210-8. 2004
    ..We show that NFAT1 is the major NFAT protein involved in regulating IL13 transcription in mast cells. Although NFAT2 is correctly expressed and regulated in mast cells, it does not contribute to IL13 gene transcription as shown by ..
  92. ncbi Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis
    Paula Elyse Schauwecker
    Department of Cell and Neurobiology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9112, USA
    J Comp Neurol 477:96-107. 2004
    ..Reduced KA-induced cell death susceptibility was observed in a congenic strain in which the highly susceptible FVB/N strain carried putative resistance alleles from the C57BL/6 strain on Chr 18...
  93. ncbi Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms
    Jana Barlic
    Molecular Signaling Section, Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:48520-34. 2004
    ..Furthermore, chromatin immunoprecipitation revealed that IL-15 promoted specific recruitment of NFAT1 but not NFAT2 to the CX3CR1 promoter, whereas IL-2 had the converse effect...
  94. ncbi Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy
    Aniko Vegvari
    Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 175:2475-83. 2005
    ..Thus, this animal model of experimentally induced spondylitis might facilitate the identification of spondylitis-susceptibility genes in humans...
  95. ncbi CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration
    Norihiro Ishida
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    J Bone Miner Res 21:48-57. 2006
    We found that a chemokine receptor gene, CCR1, acts downstream of NFAT2 in RANKL-stimulated RAW264 and bone marrow cells. The upstream regulatory region of CCR1 showed RANKL-dependent and CsA-suppressible promoter activity...
  96. ncbi Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts
    Lanying Song
    Division of Genetic and Translational Medicine, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Biol 301:276-86. 2007
    ..Taken together, our study supports the notion that Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis...
  97. ncbi Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway
    Hao Huang
    BK21 Program, Seoul National University, Seoul 110 749, Republic of Korea
    Biochem Biophys Res Commun 351:99-105. 2006
    ..forms of p38 upstream kinases MKK3 and MKK6 elicited similar reduction in RANKL-stimulated elevation of c-Fos and NFATc1. Interestingly, overexpression of c-Fos restored RANKL-induced osteoclast differentiation from and NFATc1 ..
  98. pmc Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis
    Yuanyi Feng
    Division of Genetics and Department of Cardiology, Children s Hospital Boston, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:19836-41. 2006
    ..Essential roles for FLNA in intercellular junctions provide a mechanism for the diverse developmental defects seen in patients with FLNA mutations...
  99. pmc Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres
    Tiansheng Shen
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201 1503, USA
    J Physiol 579:535-51. 2007
    ..from our laboratory have characterized the stimulation pattern-dependent nuclear import and resting shuttling of NFATc1-green fluorescent protein (GFP) in flexor digitorum brevis (FDB) muscle fibres from adult mouse...
  100. ncbi RANKL-stimulated TNFalpha production in osteoclast precursor cells promotes osteoclastogenesis by modulating RANK signaling pathways
    Akihiro Nakao
    Section of Cellular Physiology, Department of Physiological Science and Molecular Biology, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka 814 0193, Japan
    Biochem Biophys Res Commun 357:945-50. 2007
    ..Furthermore, TNFalpha production in pOCs was stimulated by RANKL. Endogenous TNFalpha in pOCs induced c-Fos and NFATc1. Expression rates of NFATc1 and c-Fos were significantly decreased in TNFalpha- and TNFRI-deficient pOCs during ..
  101. ncbi RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway
    Kaori Iwai
    Department of Clinical Research, National Hospital Organization, Osaka, Japan
    J Bone Miner Res 22:1612-20. 2007
    ..RGS18 acts through an external acidosis-sensing osteoclastogenic mechanism through the OGR1/NFAT pathway...

Research Grants4

  1. Doppler characterization of embryonic mouse circulation
    Colin Phoon; Fiscal Year: 2005
    ..abstract_text> ..
  2. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  3. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
    ..abstract_text> ..
  4. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..