Neurog3

Summary

Gene Symbol: Neurog3
Description: neurogenin 3
Alias: Atoh5, Math4B, bHLHa7, ngn3, neurogenin-3, NGN-3, Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B), atonal homolog 5, helix-loop-helix protein mATH-4B, protein atonal homolog 5
Species: mouse

Top Publications

  1. ncbi neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    L Sommer
    Division of Biology 216 76, California Institute of Technology, Pasadena, California, 91125, USA
    Mol Cell Neurosci 8:221-41. 1996
  2. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
  3. pmc Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, 465 21st Avenue South, Rm 4128, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:531-40. 2008
  4. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
  5. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
  6. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
  7. ncbi Regulation of the pancreatic pro-endocrine gene neurogenin3
    J C Lee
    Hormone Research Institute, Department of Pediatrics, University of California, San Francisco 94143, USA
    Diabetes 50:928-36. 2001
  8. pmc Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 100:5034-9. 2003
  9. ncbi Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium
    Matthew Bjerknes
    Department of Medicine, Clinical Science Division, Medical Science Building, Rm 6334, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Dev Biol 300:722-35. 2006
  10. pmc Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
    Dev Biol 314:443-56. 2008

Research Grants

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. ncbi neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    L Sommer
    Division of Biology 216 76, California Institute of Technology, Pasadena, California, 91125, USA
    Mol Cell Neurosci 8:221-41. 1996
    ..Cell 87: 43-52, 1996). Here we identify two additional ngn's, ngn2 and ngn3, which together define a novel subfamily of atonal-related mouse genes...
  2. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
    ..Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development...
  3. pmc Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, 465 21st Avenue South, Rm 4128, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:531-40. 2008
    High levels of Ngn3 expression in pancreatic progenitor cells are both necessary and sufficient to initiate endocrine differentiation...
  4. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    ..One such transcription factor, Arx, exhibits Ngn3-dependent expression throughout endocrine pancreas development in alpha, beta-precursor, and delta cells...
  5. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
    ..This role of Pax4 appears to be accomplished via its genetic interaction with another homeobox gene, Nkx2.2...
  6. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
    ..During embryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of the beta-cells and other islet cell types from pancreatic endoderm, ..
  7. ncbi Regulation of the pancreatic pro-endocrine gene neurogenin3
    J C Lee
    Hormone Research Institute, Department of Pediatrics, University of California, San Francisco 94143, USA
    Diabetes 50:928-36. 2001
    Neurogenin3 (ngn3), a basic helix-loop-helix (bHLH) transcription factor, functions as a pro-endocrine factor in the developing pancreas: by itself, it is sufficient to force undifferentiated pancreatic epithelial cells to become islet ..
  8. pmc Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 100:5034-9. 2003
    ..intestinal epithelial cells in vitro and in vivo, a process mediated by up-regulation of the Notch-related gene ngn3 and its downstream targets, which are involved in pancreatic endocrine differentiation...
  9. ncbi Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium
    Matthew Bjerknes
    Department of Medicine, Clinical Science Division, Medical Science Building, Rm 6334, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Dev Biol 300:722-35. 2006
    ..Because Neurogenin 3 (Neurog3) null mice lack enteroendocrine cells, Neurog3-expressing progenitors derived from the common ..
  10. pmc Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
    Dev Biol 314:443-56. 2008
    ..Thus, Pax6 acts upstream of MafB, which in turn may trigger the expression of insulin and regulate the PDX-1 and MafA expression required for beta-cell maturation...
  11. pmc Notch signaling controls multiple steps of pancreatic differentiation
    L Charles Murtaugh
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14920-5. 2003
    ..Furthermore, endocrine differentiation is associated with escape from this activity, because Ngn3-expressing endocrine precursors are susceptible to Notch inhibition, whereas fully differentiated endocrine cells ..
  12. doi Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells
    Margareta H Lejonklou
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Pancreas 38:259-66. 2009
    ....
  13. pmc Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  14. pmc Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
    Kelli L VanDussen
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 346:215-23. 2010
    ..Thus, Math1 is a key effector directing multipotential precursors to adopt secretory and not absorptive cell fate...
  15. pmc Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
    P Jacquemin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 1200 Brussels, Belgium
    Mol Cell Biol 20:4445-54. 2000
    ..The expression of neurogenin 3 (Ngn-3), a transcription factor that is essential for determination of endocrine cell precursors, was almost ..
  16. ncbi Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
    Miguel A Maestro
    Endocrinology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hum Mol Genet 12:3307-14. 2003
    During pancreatic organogenesis endocrine cells arise from non self-renewing progenitors that express Ngn3. The precursors that give rise to Ngn3+ cells are presumably located within duct-like structures...
  17. pmc Gata6 is an important regulator of mouse pancreas development
    Kimberly Decker
    Program in Molecular Biology, Department of Biochemistry and Molecular Genetics, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
    Dev Biol 298:415-29. 2006
    ..Conversely, the majority of transgenic Gata4-Engrailed embryos do not have a pancreatic phenotype. This study suggests that Gata6 is an important regulator of pancreas specification...
  18. pmc Sox9 coordinates a transcriptional network in pancreatic progenitor cells
    F C Lynn
    Diabetes Center, Hormone Research Institute, and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:10500-5. 2007
    ..These studies indicate that Sox9 plays a dual role in pancreatic progenitor cells: both maintaining a stable transcriptional network and supporting the programs by which these cells differentiate into distinct lineages...
  19. pmc Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    ..Thus, the regulation of Pdx1 expression by Foxa1 and Foxa2 is a key early event controlling the expansion and differentiation of the pancreatic primordia...
  20. ncbi NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas
    Korinna D Henseleit
    Department of Developmental and Cell Biology, University of California at Irvine, 4203 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3139-49. 2005
    ..We demonstrate that expression of Myt1 depends on overall Nkx6 gene dose, and therefore identify Myt1 as a possible downstream target of Nkx6 genes in the endocrine differentiation pathway...
  21. ncbi Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3
    Catherine S Lee
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 611 B, Philadelphia, 19104, USA
    Diabetes 55:269-72. 2006
    ..Neurogenin-3 (Ngn3) is a bHLH transcription factor that responds to Notch signaling and whose expression marks endocrine progenitors...
  22. ncbi MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells
    Isabella Artner
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Diabetes 55:297-304. 2006
    ..These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation...
  23. ncbi Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors
    Ioannis Serafimidis
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Stem Cells 26:3-16. 2008
    ..The transcription factor Ngn3 is required for the specification of the endocrine lineage, but its direct targets and the scope of biological ..
  24. doi Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    Xiaobo Xu
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090 Brussels, Belgium
    Cell 132:197-207. 2008
    ..Guided by the expression of Neurogenin 3 (Ngn3), the earliest islet cell-specific transcription factor in embryonic development, we show that beta cell ..
  25. pmc Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse
    Kirstine Juhl
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2755-61. 2008
    ..A further objective was to identify endocrine cell biomarkers, targets of diabetic autoimmunity, and regulatory pathways underlying islet responses to physiological and pathological stimuli...
  26. ncbi Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation
    J Jensen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 49:163-76. 2000
    ..this study, we have identified a subset of the PDX1+ epithelial cells that are marked by expression of Neurogenin3 (Ngn3)...
  27. pmc Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
    Marjorie Jenny
    INSERM U381, 3 avenue Moliere, 67200, Strasbourg, France
    EMBO J 21:6338-47. 2002
    ..We have shown previously that the basic helix- loop-helix (bHLH) transcription factor neurogenin3 (ngn3) is required for the specification of the endocrine lineage in uncommitted progenitors in the developing pancreas...
  28. ncbi Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord
    Jeffrey Lee
    IGBMC, Universite Louis Pasteur, 1 rue Laurent Fries, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Dev Biol 253:84-98. 2003
    ..As assessed by reverse transcription-polymerase chain reaction (RT-PCR), Neurogenin3 (Ngn3) was transiently expressed in bipotential glial cells fated to become either oligodendrocytes or astrocytes...
  29. ncbi Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
    Jacob Hald
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, DK 2820 Gentofte, Denmark
    Dev Biol 260:426-37. 2003
    ....
  30. pmc Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
    C Haumaitre
    Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:1490-5. 2005
    ..This study provides further insights into early molecular events controlling pancreas development and may contribute to the development of cell-replacement strategies for diabetes...
  31. pmc Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion
    Khoi Chu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Diabetes 54:1064-73. 2005
    ..These results suggest for the first time an important role for NNAT in insulin secretion and for proper beta-cell function...
  32. ncbi The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice
    Andreas Petri
    Department of Molecular Genetics, Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Mol Endocrinol 37:301-16. 2006
    ..regulating pancreatic endocrine development and function, pancreatic gene expression was compared between Ngn3-deficient mice and littermate controls on embryonic days 13 and 15...
  33. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  34. ncbi Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    Kerstin A Johansson
    Swiss Institute for Experimental Cancer Research, 155 ch des Boveresses, 1066 Epalinges, Switzerland
    Dev Cell 12:457-65. 2007
    ..of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protein under the control of the pdx1 promoter and backcrossed the transgene into the ngn3(-/-) background, ..
  35. ncbi MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  36. pmc Chronology of islet differentiation revealed by temporal cell labeling
    Takeshi Miyatsuka
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Diabetes 58:1863-8. 2009
    b>Neurogenin 3 plays a pivotal role in pancreatic endocrine differentiation...
  37. pmc The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:1888-98. 2009
    ..endocrine progenitors and a marked reduction in levels of mRNA encoding the proendocrine transcription factor neurogenin 3 (Ngn3)...
  38. pmc Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3
    Keith R Anderson
    Department of Biochemistry, University of Colorado Health Science Center, Denver, Colorado 80045, USA
    J Biol Chem 284:31236-48. 2009
    ..both proteins influence beta cell development directly downstream of the endocrine progenitor factor, neurogenin3 (Ngn3), a connection between the two proteins in the regulation of beta cell fate and function has yet to be established...
  39. pmc Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Rm 4128, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Dev Biol 339:26-37. 2010
    The basic helix-loop-helix transcription factor Neurog3 (Neurogenin3 or Ngn3) actively drives endodermal progenitor cells towards endocrine islet cell differentiation during embryogenesis...
  40. doi Neurogenin 3 cellular and subcellular localization in the developing and adult hippocampus
    Julia Simon-Areces
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    J Comp Neurol 518:1814-24. 2010
    b>Neurogenin 3 (Ngn3), a proneural gene controlled by the Notch receptor, is implicated in the control of dendrite morphology and synaptic plasticity of cultured hippocampal neurons...
  41. pmc Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
    Georg Mellitzer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    J Clin Invest 120:1708-21. 2010
    ..homeostasis, we generated mice with intestinal-specific ablation of the proendocrine transcription factor neurogenin 3 (referred to herein as Ngn3Deltaint mice)...
  42. pmc Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program
    Joris van Arensbergen
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona 08036, Spain
    Genome Res 20:722-32. 2010
    ..These findings reveal a dynamic regulation of Polycomb repression programs that shape the identity of differentiated beta-cells...
  43. doi Notch/neurogenin 3 signalling is involved in the neuritogenic actions of oestradiol in developing hippocampal neurones
    I Ruiz-Palmero
    Instituto Cajal, CSIC, Madrid, Spain
    J Neuroendocrinol 23:355-64. 2011
    ..Recent studies have shown that the Notch-regulated transcription factor neurogenin 3 controls neuritogenesis...
  44. pmc Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression
    Teresa L Mastracci
    Department of Genetics and Development, Russ Berrie Medical Pavilion, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
    Dev Biol 359:1-11. 2011
    ..of Arx in specific pancreatic cell populations established that the functions of Arx are necessary in the Neurog3+ endocrine progenitors. Together, these experiments identify novel genetic interactions between Nkx2...
  45. doi Comparison of murine embryonic pancreatic development in vitro and in vivo
    Fengxia Ma
    State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China
    Pancreas 40:1012-7. 2011
    ..The purpose of the present study was to compare the development of murine embryonic pancreas in vitro and in vivo...
  46. pmc Arx is required for normal enteroendocrine cell development in mice and humans
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, USA
    Dev Biol 365:175-88. 2012
    ..Arx expression is detected in a subset of Neurogenin3 (Ngn3)-positive endocrine progenitors and is also found in a subset of hormone-producing cells...
  47. pmc The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation
    David E Metzger
    Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1056 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 139:1447-56. 2012
    Pancreatic β-cells arise from Ngn3(+) endocrine progenitors within the trunk epithelium of the embryonic pancreas...
  48. pmc Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis
    Shouhong Xuan
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3516-28. 2012
    ..subsequent failure to induce the differentiation of progenitor cells expressing carboxypeptidase A1 (CPA1) and neurogenin 3 (NEUROG3)...
  49. ncbi Notch signalling controls pancreatic cell differentiation
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Nature 400:877-81. 1999
    ..A similar phenotype was observed in mice over-expressing neurogenin 3 (ngn 3) or the intracellular form of Notch3 (a repressor of Notch signalling)...
  50. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..neurogenin3 (ngn3) is a member of a family of basic helix-loop-helix transcription factors that is involved in the determination of ..
  51. pmc Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3
    H P Huang
    Department of Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 20:3292-307. 2000
    ..We demonstrated that the expression of neurogenin 3 (ngn3), an islet- and neuron-specific basic-helix-loop-helix transcription factor, partially overlaps that of ..
  52. ncbi Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    V M Schwitzgebel
    Hormone Research Institute, Department of Pediatrics, and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Development 127:3533-42. 2000
    ....
  53. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    ..Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation...
  54. ncbi Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas
    Lars Selander
    Department of Molecular Biology, Umeå Center for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    Mech Dev 113:189-92. 2002
    ..The data presented demonstrate that nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas...
  55. ncbi Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    Guoqiang Gu
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 129:2447-57. 2002
    ..We have employed an inducible Cre-ER(TM)-LoxP system to indelibly mark the progeny of cells expressing either Ngn3 or Pdx1 at different stages of development...
  56. pmc Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
    Catherine S Lee
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Genes Dev 16:1488-97. 2002
    ..targeting in mouse embryonic stem cells to derive an EGFP-marked null allele of the bHLH transcription factor, neurogenin 3 (ngn3)...
  57. ncbi Pancreatic cell lineage analyses in mice
    Pedro L Herrera
    Department of Morphology, University of Geneva Medical School, Switzerland
    Endocrine 19:267-78. 2002
    ..ii) p48 is involved in the exocrine and endocrine pancreatic lineages, (iii) islet endocrine cells derive from ngn3-expressing progenitor cells, and (iv) insulin cells do not derive from glucagon- expressing progenitors...
  58. ncbi Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    J Biol Chem 278:38254-9. 2003
    ..These data demonstrate how Neurogenin3 and HNF1alpha activate the pax4 gene during the cascade of gene expression events that control pancreatic endocrine cell development...
  59. ncbi Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
    Alan Hart
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Dev Dyn 228:185-93. 2003
    ..for maintaining cells in the progenitor state, in part by blocking the expression of the pro-endocrine gene neurogenin 3 (ngn3), and hence endocrine cell differentiation...
  60. ncbi Gene regulatory factors in pancreatic development
    Jan Jensen
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Dev Dyn 229:176-200. 2004
    ..Developmental Dynamics 229:176-200, 2004...
  61. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  62. ncbi Genetic determinants of pancreatic epsilon-cell development
    R Scott Heller
    Hagedorn Research Institute, Department of Developmental Biology, DK 2820 Gentofte, Denmark
    Dev Biol 286:217-24. 2005
    ....
  63. pmc IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas
    Georg Mellitzer
    INSERM U682, Development and Physiopathology of the Intestine and Pancreas, Universite Louis Pasteur, Strasbourg, France
    EMBO J 25:1344-52. 2006
    b>Neurogenin 3 (Ngn3) is key for endocrine cell specification in the embryonic pancreas and induction of a neuroendocrine cell differentiation program by misexpression in adult pancreatic duct cells...
  64. pmc Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
    Gamze Kilic
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 235:1659-67. 2006
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses...
  65. ncbi Notch and NGF/p75NTR control dendrite morphology and the balance of excitatory/inhibitory synaptic input to hippocampal neurones through Neurogenin 3
    Patricia Salama-Cohen
    Instituto Cajal de Neurobiologia, CSIC, Madrid, Spain
    J Neurochem 97:1269-78. 2006
    ..Here, we show that Neurogenin 3 is a proneural gene that is negatively regulated by Homologue of enhancer of split 1/5...
  66. ncbi p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors
    Senta Georgia
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Dev Biol 298:22-31. 2006
    ....
  67. ncbi The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3
    Yanwen Xu
    Vanderbilt University, Department of Cell and Developmental Biology, Nashville, TN 37232, USA
    Dev Biol 297:340-9. 2006
    ..Furthermore, ectopic Mfng expression induces the expression of basic helix-loop-helix gene, Ngn3, and two zinc finger genes, cMyt1 and cMyt3...
  68. ncbi Islet cell differentiation in liver by combinatorial expression of transcription factors neurogenin-3, BETA2, and RIPE3b1
    Young Duk Song
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Galter Pavillion, Suite 3 150, 251 E Huron Street, Chicago, IL 60611 2908, USA
    Biochem Biophys Res Commun 354:334-9. 2007
    ..tri-cistronic constructs were generated in hybrid adenovirus/adeno-associated virus (Ad/AAV) vectors containing neurogenin 3 (NGN3), BETA2 (NeuroD), and RIPE3b1 (MafA), each of which plays a role in islet cell differentiation...
  69. ncbi The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
    Shelley B Nelson
    Department of Developmental and Cell Biology, University of California at Irvine, 4203 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:2491-500. 2007
    ..Pdx1(+) pancreatic progenitors, whereas no rescue was observed upon expression in committed Ngn3(+) (Neurog3(+)) endocrine progenitors...
  70. pmc Recovery from diabetes in mice by beta cell regeneration
    Tomer Nir
    Department of Cellular Biochemistry and Human Genetics, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Clin Invest 117:2553-61. 2007
    ..These results suggest that regenerative therapy for type 1 diabetes may be achieved if autoimmunity is halted using regeneration-compatible drugs...
  71. ncbi Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade
    Rosa Gasa
    Diabetes and Obesity Laboratory, IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    Differentiation 76:381-91. 2008
    The related basic helix-loop-helix transcription factors neurogenin3 (Neurog3) and neurogenic differentiation 1 (NeuroD1) regulate pancreatic islet cell formation...
  72. pmc Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Room 4128, Nashville, TN 37232, USA
    Mech Dev 124:898-910. 2007
    ..The consequences of Myt1 inactivation in the developing pancreas could be masked by activation of its paralogs, Myt1l and Myt3. These findings suggest Myt1 is involved in proper endocrine differentiation and function...
  73. ncbi Defining pancreatic endocrine precursors and their descendants
    Peter White
    University of Pennsylvania, Medical School, Department of Genetics, Institute for Diabetes, Obesity and Metabolism, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 57:654-68. 2008
    ..Efforts to differentiate insulin-producing beta-cells from progenitor or stem cells require knowledge of the transcriptional programs that regulate the development of the endocrine pancreas...
  74. pmc Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells
    Jared S Burlison
    Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0225, USA
    Dev Biol 316:74-86. 2008
    ..We also found that Ptf1a is neither required for specification of Ngn3-positive endocrine progenitors nor differentiation of mature beta-cells...
  75. doi Neurogenin 2 has an essential role in development of the dentate gyrus
    Christophe Galichet
    Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
    Development 135:2031-41. 2008
    ..These data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis...
  76. doi Signals from the neural crest regulate beta-cell mass in the pancreas
    Nada Nekrep
    Diabetes Center, Hormone Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 135:2151-60. 2008
    ..2 form a non-cell-autonomous feedback loop that links the neural crest with the pancreatic epithelium, regulates the size of the beta-cell population, and thereby impacts insulin-secretory capacity and energy homeostasis...
  77. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD...
  78. pmc Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:9715-20. 2009
    Neurog3 (Neurogenin 3 or Ngn3) is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors...
  79. pmc Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window
    Corentin Cras-Méneur
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 23:2088-101. 2009
    ..this pathway by targeted deletion of presenilin1 and presenilin2, the catalytic core of gamma-secretase, in Ngn3- or Pax6-expressing endocrine progenitors...
  80. pmc Pancreatic neurogenin 3-expressing cells are unipotent islet precursors
    Renaud Desgraz
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Development 136:3567-74. 2009
    Pancreatic islet endocrine cells arise during development from precursors expressing neurogenin 3 (Ngn3)...
  81. pmc Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development
    Josselin Soyer
    Institute of Genetics and Molecular and Cell Biology IGBMC, INSERM U 964, CNRS UMR7104, University of Strasbourg, Illkirch, France
    Development 137:203-12. 2010
    The transcription factor neurogenin 3 (Neurog3 or Ngn3) controls islet cell fate specification in multipotent pancreatic progenitor cells in the mouse embryo...
  82. doi Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus
    Michelle Pelling
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Dev Biol 349:406-16. 2011
    ..We demonstrate here that Ngn3, another basic helix-loop-helix transcription factor, is expressed in mitotic progenitors in the arcuate and ..
  83. pmc Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a
    Takeshi Miyatsuka
    Diabetes Center, Hormone Research Institute and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:185-90. 2011
    ..Because transient expression of Neurogenin3 (Neurog3) in progenitor cells in the developing pancreas initiates their differentiation to mature islet cells, we ..
  84. pmc Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    Janel L Kopp
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 138:653-65. 2011
    ..pancreatic injury by partial duct ligation (PDL) has been suggested to induce β-cell regeneration from a transient Ngn3(+) endocrine progenitor cell population...
  85. pmc Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons
    Julia Simon-Areces
    Laboratory of Neuroactive Steroids, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    PLoS ONE 6:e21825. 2011
    ..However, little is known about the molecular mechanisms involved in these actions of Ngn3. We have used a microarray analysis to identify Ngn3 regulated genes related with cytoskeleton dynamics...
  86. pmc Context-specific α- to-β-cell reprogramming by forced Pdx1 expression
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 25:1680-5. 2011
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation...
  87. pmc Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development
    Anthony Beucher
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de Recherche Scientifique UMR 7104, Universite de Strasbourg, 67404 Illkirch, France
    Dev Biol 361:277-85. 2012
    During mouse pancreas development, the transient expression of Neurogenin3 (Neurog3) in uncommitted pancreas progenitors is required to determine endocrine destiny...
  88. ncbi Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 398:622-7. 1999
    ..Thus, Nkx2.2 has an essential role in interpreting graded Shh signals and selecting neuronal identity...
  89. ncbi A novel zebrafish bHLH gene, neurogenin3, is expressed in the hypothalamus
    X Wang
    Department of Biological Sciences, National University of Singapore, Singapore 119260, Singapore
    Gene 275:47-55. 2001
    ..Here we describe a zebrafish cDNA (neurogenin3 or ngn3) encoding a novel member of the Neurogenin family closest to mouse Ngn3 and human NGN3...
  90. ncbi Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis
    R Jason Kirby
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 277:4104-9. 2002
    ..The mechanism appears to be mediated through CEL hydrolysis of ceramide generated during the lipid absorption process...
  91. ncbi Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development
    H Li
    Umeå Center for Molecular Medicine, Umea University, Umea, SE 901 87, Sweden
    Dev Biol 240:247-53. 2001
    ..Thus, a total loss of Hlxb9 expression results in a block of the initiation of the dorsal pancreatic program, while a temporally extended expression of Hlxb9 results in a complete impairment of pancreatic development...
  92. ncbi Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    Seung K Kim
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Nat Genet 30:430-5. 2002
    ..In these embryos, expression of Isl1 and Atoh5, essential regulators of pancreatic morphogenesis and differentiation, was severely reduced...
  93. ncbi Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve
    Oliver Pabst
    Department of Cell and Molecular Biology, Institute of Biochemistry and Biotechnology, Technical University of Braunschweig, 38106 Braunschweig, Germany
    Development 130:1193-202. 2003
    ..Like other Nkx genes expressed in the CNS, Nkx2.9 seems to be involved in converting positional information into cell fate decisions...
  94. ncbi Single-cell transcript analysis of pancreas development
    Ming Ko Chiang
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 4:383-93. 2003
    ..This form of single-cell transcriptional analysis can be applied to any developmental process or tissue to characterize distinct cell types...
  95. ncbi FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
    Gitte Anker Norgaard
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dev Biol 264:323-38. 2003
    ..These data suggest that FGF10 signaling serves to integrate cell growth and terminal differentiation at the level of Notch activation, revealing a novel second role of this key signaling system during pancreatic development...
  96. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..1), which represses positive basic helix-loop-helix genes such as Neurog3 (ref. 3). Expression of Hes1 is controlled by the evolutionarily conserved Notch pathway...
  97. ncbi Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas
    Farzad Esni
    Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St Osler 603, Baltimore, MD 21287, USA
    Mech Dev 121:15-25. 2004
    ..Within developing pancreatic epithelium, nestin is co-expressed with pdx1 and p48, but not ngn3. Epithelial nestin expression is extinguished upon differentiation of endocrine and exocrine cell types, and no ..
  98. ncbi Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    Roque Bort
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Aveue, Philadelphia, PA 19111, USA
    Development 131:797-806. 2004
    ..Other endodermal transcription factors may also function morphogenetically rather than by directly regulating tissue-specific programs...
  99. ncbi Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
    Farzad Esni
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Development 131:4213-24. 2004
    ..These results define a normal inhibitory role for Notch in the regulation of exocrine pancreatic differentiation...
  100. pmc Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
    Dan Ma
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    J Clin Invest 114:339-48. 2004
    ..Expression of human ZAC and HYMAI in these transgenic mice thus recapitulates key features of TNDM and implicates impaired development of the endocrine pancreas and beta cell function in disease pathogenesis...
  101. ncbi Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice
    Georg Mellitzer
    Institut National de la Santé et de la Recherche Médicale Unité 381, 3 avenue Moliere, 67200 Strasbourg, France
    Mol Endocrinol 18:2765-76. 2004
    The basic helix-loop-helix transcription factor Neurogenin 3 (NGN3) controls endocrine cell fate specification in uncommitted pancreatic progenitor cells. Ngn3-deficient mice do not develop any islet cells and are diabetic...

Research Grants1

  1. GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 2005
    ..In Aim 3 we will determine the role of alternate RNA processing the insulin receptor in modulating both GK gene transcription and subcellular localization in the pancreatic beta cell. ..