Nefm

Summary

Gene Symbol: Nefm
Description: neurofilament, medium polypeptide
Alias: NF-M, NF160, NF165, Nef3, Nfm, neurofilament medium polypeptide, 160 kDa neurofilament protein, neurofilament 3, medium, neurofilament protein M, neurofilament triplet M protein, neurofilament-M
Species: mouse

Top Publications

  1. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
  2. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
  3. ncbi Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
  4. ncbi Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors
    N G Fedtsova
    Department of Psychiatry, University of California, San Diego, USA
    Mech Dev 53:291-304. 1995
  5. pmc Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons
    P C Wong
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 130:1413-22. 1995
  6. ncbi Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization
    Ok jin Kim
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Neurosci 22:5920-30. 2002
  7. ncbi Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 7:2071-84. 1993
  8. ncbi Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons
    R O'CONNOR
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143, USA
    Neuron 24:165-78. 1999
  9. pmc Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
  10. ncbi Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
    Radwan Abu-Issa
    Department of Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 129:4613-25. 2002

Research Grants

Detail Information

Publications153 found, 100 shown here

  1. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    ....
  2. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
    ..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
  3. ncbi Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
    ..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections...
  4. ncbi Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors
    N G Fedtsova
    Department of Psychiatry, University of California, San Diego, USA
    Mech Dev 53:291-304. 1995
    ..Restriction of Brn-3.0 expression to post-mitotic CNS neurons demonstrates that Brn-3.0 is not required for neurogenesis or patterning of the neuroepithelium in the CNS, but suggests a role in specification of mature neuronal phenotypes...
  5. pmc Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons
    P C Wong
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 130:1413-22. 1995
    ..Increase in NF-M did not result in an overt phenotype or neuronal loss, although filamentous swellings in perikarya and proximal axons of motor neurons were frequently found...
  6. ncbi Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization
    Ok jin Kim
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Neurosci 22:5920-30. 2002
    ..These results suggest that NF-M interacts with the D(1) receptor in vivo and may modify its expression and regulation...
  7. ncbi Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 7:2071-84. 1993
    ..These data demonstrate that Krox20 plays an essential role during development of the hindbrain and associated cranial sensory ganglia in mice...
  8. ncbi Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons
    R O'CONNOR
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143, USA
    Neuron 24:165-78. 1999
    ....
  9. pmc Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system...
  10. ncbi Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
    Radwan Abu-Issa
    Department of Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 129:4613-25. 2002
    ..This study defines the cardiovascular defects present in Fgf8 mutants and supports a role for Fgf8 in development of all the pharyngeal arches and in NCC survival...
  11. ncbi Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth
    Syann Lee
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
    Hum Mol Genet 14:627-37. 2005
    ..We further suggest that loss of necdin contributes to the neurological phenotype of PWS, and raise the possibility that co-deletion of necdin and the related protein Magel2 may explain the lack of single gene mutations in PWS...
  12. ncbi Axonal atrophy in aging is associated with a decline in neurofilament gene expression
    I M Parhad
    Department of Pathology, University of Calgary, Alberta, Canada
    J Neurosci Res 41:355-66. 1995
    ..Although the mechanisms leading to the decrease in Nf gene expression with aging are not known, a decrease in the availability of growth factors, or the neuron's ability to respond to them, may play a role in this process...
  13. ncbi Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column
    D Kostic
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 46:231-47. 1994
    ..The analysis of double, triple and even quadruple mutants should determine the ways in which these Hox genes interact in order to specify the multitude of tissues in a restricted region of the developing mouse embryo...
  14. ncbi Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process
    H Saegusa
    Kanagawa Academy of Science and Technology in Meiji Institute of Health Science, Japan
    Dev Biol 174:55-64. 1996
    ..Although Hoxc-4 is expressed abundantly in the central nervous system, no obvious defects were observed. These results suggest that Hoxc-4 is required for specifying cervical and thoracic vertebral identity...
  15. pmc Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC
    E J Huang
    Program in Neuroscience, Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723, USA
    Development 126:2191-203. 1999
    ..Therefore, our data provide evidence that NT-3 supports the survival of TrkA-, TrkB- and TrkC-expressing neurons in the trigeminal ganglion by activating directly each of these receptors in vivo...
  16. ncbi The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4
    I Pata
    Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    Development 126:5523-31. 1999
    ..These findings demonstrate that GATA2 and GATA3 lie downstream of Hoxb1 and provide the first example of Hox pathway transcription factors within a defined population of vertebrate motor neurons...
  17. ncbi Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons
    F Helmbacher
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 127:3313-24. 2000
    ..Our data therefore suggest that the level of EphA4 protein in growing limb motor axons is involved in the selection of dorsal versus ventral trajectories, thus contributing to the topographic organisation of motor projections...
  18. ncbi Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6
    Georges Nemer
    Laboratoire de developpement et differenciation cardiaques, Institut de recherches cliniques de Montreal IRCM, Canada
    Dev Biol 254:131-48. 2003
    ..They also raise the possibility that part of the early defects in GATA-4 and/or GATA-6 null embryos may be due to impaired BMP-4 signaling...
  19. pmc Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality
    M Parrish
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Cell Biol 24:7102-12. 2004
    ..These studies indicate that Sall3 is required for the development of nerves that are derived from the hindbrain and for the formation of adjacent branchial arch derivatives...
  20. pmc Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin
    Silvia Pagliardini
    Department of Physiology, Centre of Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Am J Pathol 167:175-91. 2005
    ....
  21. ncbi A genetic screen for mutations that affect cranial nerve development in the mouse
    Lynn Mar
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    J Neurosci 25:11787-95. 2005
    ....
  22. pmc Epibranchial ganglia orchestrate the development of the cranial neurogenic crest
    Eva Coppola
    Institut de Biologie de l Ecole Normale Supérieure, Centre National de la Recherche Scientifique UMR8197, Institut National de la Santé et de la Recherche Médicale U1024, 75005 Paris, France
    Proc Natl Acad Sci U S A 107:2066-71. 2010
    ....
  23. doi β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart
    Youngsin Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 240:271-7. 2011
    ..These data are the first to identify cell adhesion and signaling pathways regulated by αvβ8 integrin and Band 4.1B as essential for normal formation and function of the heart during embryogenesis...
  24. pmc Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
    P H Tu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    J Cell Biol 129:1629-40. 1995
    ..system (CNS) and peripheral nervous system (PNS) neurons, are heteropolymers formed from the high (NFH), middle (NFM), and low (NFL) molecular weight NF subunits...
  25. ncbi Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
    E Y Lee
    Center for Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245
    Genes Dev 8:2008-21. 1994
    ..Taken together, these results suggest that the p110RB protein not only regulates progression through the cell cycle but is also important for cell survival and differentiation...
  26. ncbi Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
    J M Goddard
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
    Development 122:3217-28. 1996
    ..These animals should therefore provide a useful animal model for these human diseases...
  27. pmc Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors
    I Farinas
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:1065-78. 1996
    ..Although deficits occur before final target innervation, we show that NT-3 is expressed at all stages in regions accessible to these neurons or their axons and is only restricted to final targets after innervation...
  28. ncbi lunatic fringe is an essential mediator of somite segmentation and patterning
    Y A Evrard
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nature 394:377-81. 1998
    ....
  29. ncbi LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
    K Sharma
    Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Cell 95:817-28. 1998
    ..Thus, Lhx3 and Lhx4 act in a binary fashion during a brief period in development to specify the trajectory of motor axons from the neural tube...
  30. ncbi Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, CU de Strasbourg, France
    Development 126:5051-9. 1999
    ....
  31. ncbi Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb
    A Kania
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 102:161-73. 2000
    ..Thus, LIM homeodomain proteins act within motor neurons and cells that guide motor axons to establish the fidelity of a binary choice in axonal trajectory...
  32. ncbi Notch1 is required for neuronal and glial differentiation in the cerebellum
    Simone Lütolf
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    Development 129:373-85. 2002
    ..We have also analyzed the effects of Notch1 ablation on gliogenesis in vivo. Our results show that Notch1 is required for both neuron and glia formation and modulates the onset of neurogenesis within the cerebellar neuroepithelium...
  33. ncbi GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
    Georg Haase
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, Marseille, France
    Neuron 35:893-905. 2002
    ..Thus, GDNF acts as a peripheral signal to induce PEA3 expression in specific motor neuron pools thereby regulating both cell body position and muscle innervation...
  34. ncbi The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 130:2525-34. 2003
    ..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm...
  35. ncbi Neuromuscular synapses mediate motor axon branching and motoneuron survival during the embryonic period of programmed cell death
    Glen B Banks
    School of Biomedical Sciences, Department of Physiology and Pharmacology and SRC for Bio informatics and Applied Genomics, University of Queensland, 4072, St Lucia, Queensland, Australia
    Dev Biol 257:71-84. 2003
    ..Thus, agrin-induced synaptic specializations are required for skeletal muscle to effectively control motoneuron numbers during embryonic development...
  36. ncbi Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina
    Jimmy de Melo
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Comp Neurol 461:187-204. 2003
    ....
  37. ncbi Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism
    Weichun Lin
    The Salk Institute, La Jolla, California 92037, USA
    Neuron 46:569-79. 2005
    ..Genetic elimination of Cdk5 or blocking ACh production prevents the dispersion of AChR clusters in agrin mutants. Therefore, we propose that ACh negatively regulates neuromuscular synapse formation through a Cdk5-dependent mechanism...
  38. pmc Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis
    Angelo Iulianella
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Development 135:729-41. 2008
    ..Thus our work defines novel roles for Cux2 as a transcription factor that integrates cell-cycle progression with neural progenitor development during spinal cord neurogenesis...
  39. pmc Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice
    Yoshiaki Kubota
    Department of Cell Differentiation, Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    J Clin Invest 118:2393-403. 2008
    ....
  40. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993
    ..We conclude that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development...
  41. ncbi Notch1 is essential for postimplantation development in mice
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:707-19. 1994
    ..These results demonstrate that the Notch1 gene plays a vital role during early postimplantation development in mice...
  42. ncbi Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    S L Pfaff
    Howard Hughes Medical Institute, Department of Biochemistry and Molecule Biophysics, Columbia University, New York, New York 10032, USA
    Cell 84:309-20. 1996
    ..These results show that ISL1 is required for the generation of motor neurons and suggest that motor neuron generation is required for the subsequent differentiation of certain interneurons...
  43. ncbi Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Dev Biol 192:274-88. 1997
    ..This suggests that the identity of the specific Hox genes that are functional in a given region may not be as critical as the total number of Hox genes operating in that region...
  44. ncbi Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:813-24. 1998
    ..These observations define a novel genetic pathway for inductive communication between cephalic neural crest cells and their environmental counterparts...
  45. pmc Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo
    I Farinas
    Department of Physiology, University of California, San Francisco 94143, USA
    Neuron 21:325-34. 1998
    ..Results also indicate that survival of cells expressing both receptors can be maintained by activation of either one alone. NT-3 can thus activate more than one Trk receptor in vivo, which when coexpressed are functionally redundant...
  46. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  47. pmc Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice
    W Lin
    The Salk Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:1299-304. 2000
    ..The postsynaptic defect features an impairment of junctional folds at the neuromuscular synapse in the mutants. These results demonstrate that erbB2 is essential for in vivo development of the NMJ...
  48. ncbi p75 is important for axon growth and schwann cell migration during development
    C A Bentley
    The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 20:7706-15. 2000
    ..These results provide evidence that p75 is important in the developing embryo for regulating axon growth and arborization and for Schwann cell migration...
  49. ncbi Roles of Meltrin beta /ADAM19 in the processing of neuregulin
    K Shirakabe
    Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 276:9352-8. 2001
    ..Furthermore, the effects of the secretory pathway inhibitors suggested that meltrin beta participates in the intracellular processing of NRGs rather than the cleavage on the cell surface...
  50. ncbi Hoxa3 regulates integration of glossopharyngeal nerve precursor cells
    N Watari
    Department of Cell and Developmental Biology, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Dev Biol 240:15-31. 2001
    ..In summary, the Hoxa3 gene has crucial roles in ensuring the correct axon projection pattern of all three components of the IXth nerve, i.e., motor neurons and sensory neurons of the proximal and distal ganglia...
  51. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  52. ncbi Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice
    Eugene P Brandon
    Laboratory of Genetics and Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:539-49. 2003
    ..These results indicate that ChAT is uniquely essential for the patterning and formation of mammalian neuromuscular synapses...
  53. ncbi Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression
    David Andrieu
    Neurogenèse et Morphogenèse dans le Développement et chez l Adulte, CNRS UMR 6156, Institut de Biologie du Développement de Marseille IBDM, Case 907, Campus de Luminy, 13288 Cedex 9, Marseille, France
    Gene Expr Patterns 3:761-5. 2003
    ..Furthermore, they are also consistent with the putative role of Necdin in signaling events promoted by p75NTR during mouse nervous system development...
  54. pmc NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth
    Michael L Garcia
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Cell Biol 163:1011-20. 2003
    ..This has revealed that the tail domain of NF-M, with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons...
  55. pmc Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Genes Dev 18:937-51. 2004
    ..Further, our analysis of Shh-Fox gene regulatory interactions leads us to propose that Fox genes mediate the action of Shh in facial development...
  56. ncbi Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives
    Takashi Inoue
    Laboratory for Developmental Neurobiology and Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Dev Biol 270:146-62. 2004
    ..Based on both their similar expression pattern in mouse embryos and the malformations observed in Zic5-deficient mutant mice, human ZIC5 might be involved in the deletion syndrome...
  57. ncbi Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development
    Daniel G M Molin
    Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, 2300 RC Leiden, The Netherlands
    Circ Res 95:1109-17. 2004
    ..We hypothesize that disturbed maturation of the fourth pharyngeal arch artery, and especially abrogated vascular innervation, will result in fourth arch interruptions...
  58. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
    ..Herein, we propose a model whereby early-born RGCs are Dlx1 and Dlx2 independent, but Dlx function is necessary for terminal differentiation of late-born RGC progenitors...
  59. ncbi Protocadherin Celsr3 is crucial in axonal tract development
    Fadel Tissir
    Developmental Neurobiology Unit, University of Louvain Medical School, 73, Avenue Mounier, Box DENE7382, B 1200 Brussels, Belgium
    Nat Neurosci 8:451-7. 2005
    ..Celsr3 and Fzd3 are expressed together during brain development and may act in synergy. Thus, a genetic pathway analogous to the one that controls PCP is key in the development of the axonal blueprint...
  60. ncbi Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance
    Fumikazu Suto
    Division of Developmental Genetics, National Institute of Genetics, Mishima 411 8540, Japan
    J Neurosci 25:3628-37. 2005
    ..Our results imply that plexin-A4 mediates multiple semaphorin signals and regulates axon guidance in vivo...
  61. pmc Vax genes ventralize the embryonic eye
    Stina H Mui
    Molecular Neurobiology Laboratory, The Salk Institute La Jolla, California 92037, USA
    Genes Dev 19:1249-59. 2005
    ....
  62. pmc Multiple requirements for Hes 1 during early eye formation
    Hae Young Lee
    Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Dev Biol 284:464-78. 2005
    ..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
  63. pmc Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice
    Amy K Y Fu
    Department of Biochemistry, Biotechnology Research Institute, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Proc Natl Acad Sci U S A 102:15224-9. 2005
    ..Taken together, our findings reveal the essential role of Cdk5 in regulating the development of motor axons and neuromuscular synapses in vivo...
  64. ncbi Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
    Mamoru Ishii
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Development 132:4937-50. 2005
    ..This increase in apoptosis may contribute to the mispatterning of the cranial ganglia and the hypoplasia of the first arch...
  65. ncbi Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling
    Yanshu Wang
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:355-64. 2006
    ..This work demonstrates the usefulness of muDTI and genetically directed neuronal labeling for the analysis of nervous system defects in the mouse...
  66. ncbi The muscle protein Dok-7 is essential for neuromuscular synaptogenesis
    Kumiko Okada
    Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Science 312:1802-5. 2006
    ..Mice lacking Dok-7 formed neither acetylcholine receptor clusters nor neuromuscular synapses. Thus, Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK...
  67. ncbi Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 26:10006-19. 2006
    ....
  68. ncbi LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction
    Scott D Weatherbee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Development 133:4993-5000. 2006
    ..The identification of Lrp4 as a crucial factor for NMJ formation may have implications for human neuromuscular diseases such as myasthenia syndromes...
  69. ncbi LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
    Anthony P Barnes
    Neuroscience Center, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 129:549-63. 2007
    ..Thus, we provide evidence in vivo and in vitro for a multikinase pathway that links extracellular signals to the intracellular machinery required for axon specification...
  70. pmc Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
    Victor Luria
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Neural Dev 2:13. 2007
    ..The cellular logic that guides motor axon trajectory choices into non-limb tissues such as the ventral flank remains unclear...
  71. pmc Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development
    Sophie Chauvet
    Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Neuron 56:807-22. 2007
    ..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits...
  72. doi Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton
    Emily T Shifley
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    Development 135:899-908. 2008
    ....
  73. pmc Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning
    Yun Liu
    Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9111, USA
    Development 135:1957-67. 2008
    ..These results demonstrate that the gamma-subunit is required for the formation of pre-patterned AChR clusters, which in turn play an essential role in determining the subsequent pattern of neuromuscular synaptogenesis...
  74. pmc Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
    Shingo Kariya
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Hum Mol Genet 17:2552-69. 2008
    ..We suggest that SMA might best be described as a NMJ synaptopathy and that one promising means of treating it could involve maintaining function at the NMJ...
  75. pmc Fibulin-1 is required for morphogenesis of neural crest-derived structures
    Marion A Cooley
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Dev Biol 319:336-45. 2008
    ....
  76. doi Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb
    Victor Luria
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 60:1039-53. 2008
    ..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program...
  77. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..How cyclin D1 influences RPC behavior, especially during the embryonic period, is unclear...
  78. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate...
  79. doi Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance
    Alexander Jaworski
    Division of Research, Genentech Inc, South San Francisco, California 94080, USA
    J Neurosci 30:9445-53. 2010
    ..In contrast, Robo1 prevents axonal stalling after crossing. Our results reveal specialized and complementary actions of Robo1 and Robo2 in commissural axon guidance and suggest the existence of an as yet unidentified Slit receptor...
  80. doi Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg
    Dev Biol 359:230-41. 2011
    ..Thus, initial hypoglossal nerve assembly and fasciculation, but not later guidance decisions depend on Npn-1 expression and axon-Schwann cell interactions...
  81. pmc Dystroglycan organizes axon guidance cue localization and axonal pathfinding
    Kevin M Wright
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 76:931-44. 2012
    ..These findings establish a novel role for glycosylated dystroglycan as a key determinant of axon guidance cue distribution and function in the mammalian nervous system...
  82. ncbi Notch1 is required for the coordinate segmentation of somites
    R A Conlon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 121:1533-45. 1995
    ..However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur...
  83. ncbi Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein
    J Eyer
    Department of Neurology and Neurosurgery, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Neuron 12:389-405. 1994
    ..We conclude that an organized neurofilament cytoskeleton is required by axons to achieve large calibers but is not essential for neuronal function or extended survival...
  84. ncbi Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation
    M Burmeister
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Nat Genet 12:376-84. 1996
    ..off..
  85. pmc Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization
    Y Qiu
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 11:1925-37. 1997
    ..Furthermore, mCOUP-TFI possesses vital physiological functions that are distinct from mCOUP-TFII despite of their high degree of homology and extensive overlapping expression patterns...
  86. pmc Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content
    G A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York 10029, USA
    J Cell Biol 141:727-39. 1998
    ..These studies suggest that the NF-M subunit is a major regulator of the level of NF-L and that its presence is required to achieve maximal axonal diameter in all size classes of myelinated axons...
  87. ncbi Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain
    B Kablar
    Institute for Molecular Biology and Biotechnology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    Dev Biol 208:93-109. 1999
    ..The epaxial and cutaneous component of dorsal ramus failed to form in the absence of the myotome. Therefore, we conclude that nervous development is more intimately coupled to skeletal myogenesis than has previously been understood...
  88. ncbi Dlx5 regulates regional development of the branchial arches and sensory capsules
    M J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology, Oral Biology and Biomedical Sciences, University of California at San Fran
    Development 126:3831-46. 1999
    ....
  89. ncbi The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton
    G M Wahba
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, California 90024, USA
    Dev Biol 231:87-102. 2001
    ..Animals carrying fewer mutant alleles show similar, but less extreme phenotypes. These observations suggest that Hoxa10 and Hoxd10 coordinately regulate skeletal development and innervation of the hindlimb...
  90. ncbi Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
    X Yang
    Molecular Neurobiology Program, Skirball Institute, New York University Medical School, New York, NY 10011, USA
    Neuron 30:399-410. 2001
    ..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation...
  91. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    ..Our data show that Fgf8 is part of a complex gene regulatory network that is essential for cell survival in the mes/met...
  92. ncbi Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm
    Scott E Williams
    Departments of Pathology, Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Neuron 39:919-35. 2003
    ..EphB1 null mice exhibit a dramatically reduced ipsilateral projection, suggesting that this receptor contributes to the formation of the ipsilateral retinal projection, most likely through its repulsive interaction with ephrin-B2...
  93. pmc The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate
    Mala V Rao
    Nathan Kline Institute, NYU School of Medicine, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    J Cell Biol 163:1021-31. 2003
    ....
  94. ncbi Essential roles of Meltrin beta (ADAM19) in heart development
    Kazuto Kurohara
    Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Dev Biol 267:14-28. 2004
    ..These results suggest the necessity of proteolytic regulation of ErbB ligands by Meltrin beta for proper heart development...
  95. ncbi Suppression of neural fate and control of inner ear morphogenesis by Tbx1
    Steven Raft
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 131:1801-12. 2004
    ..We propose that Tbx1 acts in the manner of a selector gene to control neural and sensory organ fate specification in the otocyst...
  96. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
    ..Furthermore, our data link, for the first time, the function of the secondary heart field to congenital heart disease...
  97. pmc Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type
    Gary T Philips
    Biology Department, University of Nevada, Biology 200, 1664 N Virginia Street, Reno, NV 89557, USA
    Dev Biol 279:308-21. 2005
    ..Subsequently, precocious neurons adopted a generic rather than a specific retinal neuron fate. Thus, Pax6 regulates the timing of retinal neurogenesis and couples it with specific neuron differentiation programs...
  98. ncbi Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9, Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Gene Expr Patterns 5:517-23. 2005
    ..The intensely overlapping localization of betaIII-tubulin and MUK/DLK/ZPK indicated that this protein kinase is tightly associated with the microtubules of neurons...
  99. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  100. ncbi Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein
    E Levy
    Eur J Biochem 166:71-7. 1987
    ..Consistent with this notion, we show that the genes encoding NF-M and NF-L are linked...
  101. ncbi The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons
    C Fode
    IGBMC, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Neuron 20:483-94. 1998
    ..Interestingly, the homeobox gene Phox2a is activated independently of ngn2 in epibranchial placodes, suggesting that neuronal fate and neuronal subtype identity may be specified independently in cranial sensory ganglia...

Research Grants7

  1. TRANSCRIPTION FACTORS REGULATING PALATOGENESIS
    Douglas Darling; Fiscal Year: 2002
    ..Subsequent work will investigate the molecular mechanism(s) of Zfhep action during craniofacial development. ..
  2. Identifying Periodontal Antigens By Protein Microarray
    Douglas Darling; Fiscal Year: 2006
    ..The R21 Exploratory Grant is an appropriate mechanism since proteomics have not been used for periodontal disease, and bacterial genomic expression libraries and antigen microarrays need to be developed. [unreadable] [unreadable]..
  3. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Douglas Darling; Fiscal Year: 2007
    ..This will lead to a better understanding of the formation of saliva and provide the basis for efficient delivery of therapeutic proteins from salivary glands. ..
  4. Molecular Regulation of TIMP-2 in Neuron Cell Cycle
    DIANE JAWORSKI; Fiscal Year: 2007
    ..abstract_text> ..
  5. Molecular Mechanisms of Thalamocortical Development
    NOELLE DWYER; Fiscal Year: 2008
    ..Combining the expertise in mouse genetics with the previous training in mouse neuroanatomy and nematode genetics will significantly add to the Candidate's potential to make a strong impact on the field. ..
  6. Ocular defects caused by TCF8/Zfhx1a mutations
    Douglas Darling; Fiscal Year: 2008
    ..This directly relates to the National Eye Institute program's goal to investigate the development of the visual system. [unreadable] [unreadable] [unreadable]..