Genomes and Genes
Gene Symbol: Nefh
Description: neurofilament, heavy polypeptide
Alias: NF-H, NF200, Nfh, mKIAA0845, neurofilament heavy polypeptide, 200 kDa neurofilament protein, neurofilament 200kDa, neurofilament triplet H protein
Publications125 found, 100 shown here
- Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALSChristian S Lobsiger
Ludwig Institute for Cancer Research and Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 102:10351-6. 2005....
- Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanismsBalazs Hegedus
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Cell Stem Cell 1:443-57. 2007..Together, these findings demonstrate that neurofibromin is required for normal glial and neuronal development involving separable Ras-dependent and cAMP-dependent mechanisms...
- Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivityCeng Luo
Pharmacology Institute, University of Heidelberg, Heidelberg, Germany
PLoS Biol 10:e1001283. 2012....
- Involvement of Wnt-1 in the formation of the mes/metencephalic boundaryL Bally-Cuif
INSERM U106, Hopital de la Salpetriere, Paris, France
Mech Dev 53:23-34. 1995....
- Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephalyD Hartmann
Anatomisches Institut der CAU Kiel, Otto Hahn Platz 8, D 24 118, Kiel, Germany
Curr Biol 9:719-27. 1999..Physiologically, the presenilins are involved in the Notch and Wnt-beta-catenin signaling pathways...
- Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1M D Nguyen
Centre for Research in Neurosciences, McGill University, The Montreal General Hospital Research Institute, Montreal, PQ H3G 1A4, Canada
Proc Natl Acad Sci U S A 97:12306-11. 2000..These results do not support the current view that high NF content and large caliber of axons may account for the selective vulnerability of motor neurons in ALS caused by mutant SOD1...
- Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels Roberto Buccafusca
Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
Mol Genet Metab 95:81-95. 2008..In conclusion, in neonatal brain tissue, Mrps6 gene expression may not be contingent on function of its embedded Slc5a3 gene, while inositide deficiency may not be the mechanism of lethal apnea in null Slc5a3 mice...
- Cloning and developmental expression of the murine neurofilament gene familyJ P Julien
Brain Res 387:243-50. 1986..The NF-L and NF-M mRNAs are detected early in the embryonal brain, with a progressive increase in their levels during development, while the NF-H mRNA is barely detectable at embryonal stages and accumulates later in the postnatal brain...
- The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding itJ F Lees
Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892
EMBO J 7:1947-55. 1988..The human NF-H gene has three introns, two of which interrupt the protein-coding sequence at identical points to introns in the genes for the two smaller NF proteins, NF-M and NF-L.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosisJ F Collard
Centre for Research in Neurosciences, McGill University, Montreal General Hospital Research Institute, Canada
Nature 375:61-4. 1995....
- Axonal atrophy in aging is associated with a decline in neurofilament gene expressionI M Parhad
Department of Pathology, University of Calgary, Alberta, Canada
J Neurosci Res 41:355-66. 1995..Although the mechanisms leading to the decrease in Nf gene expression with aging are not known, a decrease in the availability of growth factors, or the neuron's ability to respond to them, may play a role in this process...
- Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosisD A Figlewicz
Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada
Hum Mol Genet 3:1757-61. 1994..The C-terminal region of the human neurofilament heavy subunit (NEFH) contains a unique functional domain consisting of 43 repeat motifs of the amino acids Lys-Ser-Pro (KSP)...
- Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosisF Cote
Centre for Research in Neurosciences McGill University, Canada
Cell 73:35-46. 1993....
- Defective neuromuscular synaptogenesis in agrin-deficient mutant miceM Gautam
Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
Cell 85:525-35. 1996....
- Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transportJ R Marszalek
Division of Cellular and Molecular Medicine, University of California at San Diego, La Jolla 92093, USA
J Cell Biol 135:711-24. 1996....
- Developmental expression of BPAG1-n: insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum miceJ Dowling
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, Chicago, Illinois 60637, USA
Dev Biol 187:131-42. 1997..Collectively, our findings suggest a mechanism for the BPAG1 null phenotype and indicate that different neurons respond differently to the absence of BPAG1-n, a cytoskeletal linker protein...
- Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylationM V Rao
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA
J Cell Biol 143:171-81. 1998....
- Requirement of heavy neurofilament subunit in the development of axons with large calibersG A Elder
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Cell Biol 143:195-205. 1998..These results demonstrate directly that unlike losing the NF-L or NF-M subunits, loss of NF-H has only a slight effect on NF number in axons. Yet NF-H plays a major role in the development of large diameter axons...
- Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunitsH Jacomy
Montreal General Hospital Research Institute, Quebec, Canada
J Neurochem 73:972-84. 1999..The combined results demonstrate a requirement of the high-molecular-weight subunits for the assembly of type IV intermediate filament proteins and for the efficient translocation of NF-L proteins into the axonal compartment...
- Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transportMala V Rao
Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY 10962, USA
J Cell Biol 158:681-93. 2002..Most surprisingly, at least in optic nerve axons, loss of the NF-H tail does not affect the rate of transport of neurofilament subunits...
- Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament densityMala V Rao
Center for Dementia Research, Nathan Kline Institute, NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
J Cell Biol 159:279-90. 2002....
- NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthMichael L Garcia
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
J Cell Biol 163:1011-20. 2003..This has revealed that the tail domain of NF-M, with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons...
- Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNSAidong Yuan
Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
J Neurosci 26:10006-19. 2006....
- The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypesThomas W Gould
Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
J Neurosci 28:2131-46. 2008..Therefore, although GDNF influences several aspects of MN development, the survival-promoting effects of GDNF during programmed cell death are mostly confined to spindle-innervating MNs...
- Merkel cells are essential for light-touch responsesStephen M Maricich
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Science 324:1580-2. 2009..Merkel cells are, therefore, required for the proper encoding of Merkel receptor responses, suggesting that these cells form an indispensible part of the somatosensory system...
- Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasisAlexandra Van Keymeulen
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels B 1070, Belgium
J Cell Biol 187:91-100. 2009..Our study demonstrates that MCs arise from the epidermis by an Atoh1-dependent mechanism and opens new avenues for study of MC functions in sensory perception, neuroendocrine signaling, and MC carcinoma...
- Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signalingSteeve Bourane
INSERM U 583, F34091 Montpellier, France
Neuron 64:857-70. 2009..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs...
- Gata3 is a critical regulator of cochlear wiringJessica M Appler
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 33:3679-91. 2013..As the first auditory-specific regulator of SGN development, Gata3 provides a useful molecular entry point for efforts to engineer SGNs for the restoration of hearing...
- Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunitsP H Tu
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
J Cell Biol 129:1629-40. 1995..central nervous system (CNS) and peripheral nervous system (PNS) neurons, are heteropolymers formed from the high (NFH), middle (NFM), and low (NFL) molecular weight NF subunits...
- Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion proteinJ Eyer
Department of Neurology and Neurosurgery, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
Neuron 12:389-405. 1994..mice expressing a fusion protein in which the carboxyl terminus of the high molecular weight neurofilament protein (NFH) was replaced by beta-galactosidase. The transgene, regulated by NFH sequences, was expressed in projection neurons...
- Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerveElli Chatzopoulou
Institut National de la Sante et de la Recherche Medicale, Unité 711, Universite Pierre et Marie Curie, Faculte de Medecine, Hopital de la Salpetriere, Institut Fédératif de Recherche 70, F 75013 Paris, France
J Neurosci 28:7624-36. 2008..Therefore, TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve...
- Sequence and structure of the mouse gene coding for the largest neurofilament subunitJ P Julien
Institut du Cancer de Montreal, Centre Hospitalier Notre Dame, Canada
Gene 68:307-14. 1988..The nfh gene shares two common intron positions with the nfl and nfm genes, but has an additional intron that occurs at a ..
- Expanding roles for alpha 4 integrin and its ligands in developmentA M Sheppard
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
Cell Adhes Commun 2:27-43. 1994..Finally, based on their patterns of expression, we conclude that VCAM-1 only participates in a subset of interactions involving alpha 4 integrins, whereas FN appears to be the more general ligand...
- Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrileQ Zhu
Centre for Research in Neuroscience, McGill University, The Montreal General Hospital Research Institute, Montreal, Quebec, Canada H3G 1A4
J Cell Biol 143:183-93. 1998..These results indicate that the NF-H subunit is a key mediator of IDPN-induced axonopathy...
- Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubulesG A Elder
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurosci Res 57:23-32. 1999..Thus in vivo rodent neurofilaments are obligate heteropolymers requiring NF-L plus either NF-M or NF-H to form a filamentous network...
- Negative regulatory regions are present upstream in the three mouse neurofilament genesP S Shneidman
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia 19104 6079
Brain Res Mol Brain Res 13:127-38. 1992..The role of the negative elements in regulating NF expression remains unclear...
- Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10R S Yeung
Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
Proc Natl Acad Sci U S A 90:8038-42. 1993..Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC...
- 43K protein and acetylcholine receptors colocalize during the initial stages of neuromuscular synapse formation in vivoP G Noakes
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
Dev Biol 155:275-80. 1993..The precise colocalization of 43K and AChRs persisted through development. These results are consistent with 43K being involved in the nerve-induced clustering of AChRs during synapse formation...
- Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube developmentM Lardelli
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
Mech Dev 59:177-90. 1996....
- Distribution of neuronal intermediate filament proteins in the developing mouse olfactory systemC L Chien
Department of Anatomy, College of Medicine, National Taiwan University, Taipei, Republic of China
J Neurosci Res 54:353-63. 1998..Our results suggest that alpha-internexin may play a functional role in the neuronal cytoarchitecture of developing olfactory system, and can be a neuronal marker for detecting postmitotic migrating neurons in the adult olfactory bulb...
- Cytoskeletal abnormalities in amyotrophic lateral sclerosis: beneficial or detrimental effects?J P Julien
Centre for Research in Neurosciences, McGill University, The Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
J Neurol Sci 180:7-14. 2000..These results together with the detection of peripherin inclusions at early stage of disease in mice expressing mutant SOD1 suggest that IF inclusions containing peripherin may play a contributory role in ALS pathogenesis...
- Postnatal regulation of limb proprioception by muscle-derived neurotrophin-3M D Taylor
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Comp Neurol 432:244-58. 2001..However, our results also show that NT-3 may be therapeutic for proprioceptive axons immediately after nerve injury by delaying axon degeneration...
- High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenalTakafumi Wataya
Institute of Pathology and Departments of Physiology and Biophysics, and Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 277:4644-8. 2002..Immunoblots of axonal proteins showed that HNE adducts are only detected in neurofilament heavy subunit (NFH) and, to a lesser extent, neurofilament medium subunit (NFM), both lysine-rich proteins, consistent with the ..
- Math3 and NeuroD regulate amacrine cell fate specification in the retinaTomoyuki Inoue
Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
Development 129:831-42. 2002....
- Frizzled-3 is required for the development of major fiber tracts in the rostral CNSYanshu Wang
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 22:8563-73. 2002..In contrast, there is little cell death, as assayed by terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, in the cortex. These data provide the first link between Frizzled signaling and axonal development...
- Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null miceAnna Corradi
San Raffaele Scientific Institute, Milan, Italy
Development 130:401-10. 2003..Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development...
- Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteinsJean Martin Beaulieu
Centre for Research in Neurosciences, McGill University, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
J Neurochem 85:248-56. 2003..These findings illustrate the importance of IF protein stoichiometry in formation, localization and toxicity of neuronal inclusion bodies...
- A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3Wenlin Yuan
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:5217-22. 2003..This study establishes the first genetic model for CDH and identifies a previously unsuspected role for Slit3 in regulating the development of the diaphragm...
- Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neuronsShannon D Shields
Departments of Anatomy and Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
Pain 131:8-20. 2007..To date we have not detected a differential phenotype suggestive of a functional contribution of AQP1 to nociceptive processing...
- Divergent roles of ApoER2 and Vldlr in the migration of cortical neuronsIris Hack
Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
Development 134:3883-91. 2007..We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons...
- Patterned neuropathologic events occurring in hyh congenital hydrocephalic mutant micePatricia Páez
Departamento de Biologia Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Malaga, Malaga, Spain
J Neuropathol Exp Neurol 66:1082-92. 2007..All evidence collected on hydrocephalic hyh mutant mice indicates that a primary alteration in the neuroepithelium/ependyma cell lineage triggers both hydrocephalus and abnormalities in telencephalic development...
- Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in miceJan C Holstege
Department of Neuroscience, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Proc Natl Acad Sci U S A 105:6338-43. 2008..The data therefore suggest that a lower number of neurons in the upper spinal laminae and neuronal disorganization in the dorsal horn underlie the sensory defects including the excessive grooming of the Hoxb8 mutant...
- Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cellsSophie Grimal
INSERM U583, Institut des Neurosciences de Montpellier, Université Montpellier II Hôpital Saint Eloi, 80 rue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5
Glia 58:1977-87. 2010....
- Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neuronsDaniel J Cavanaugh
Departments of Anatomy, University of California, San Francisco, California 94158, USA
J Neurosci 31:10119-27. 2011....
- Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in miceAkinobu Matsumoto
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka, Fukuoka 812 8582, Japan
Mol Cell Biol 31:4176-92. 2011..Our results thus implicate p57 in cell cycle arrest in the subcommissural organ and Pax2-positive interneuron precursors, with the lack of p57 resulting in induction of p53-dependent apoptosis due to hyperactivation of E2F1...
- Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touchHind Abdo
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Eur J Neurosci 34:1529-41. 2011..These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin...
- Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptorSeung Hyun Woo
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Development 139:740-8. 2012..The molecular basis for piloneural development, maintenance and function is poorly understood. Here, we show that Nefh-expressing glutamatergic neurons represent a major population of longitudinal and circumferential sensory afferents ..
- A novel function for the survival motoneuron protein as a translational regulatorGabriel Sanchez
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5
Hum Mol Genet 22:668-84. 2013..Importantly, an SMA-causing mutation in the Tudor domain of SMN completely abolished translational repression, a strong indication for the functional significance of this novel SMN activity in the pathology...
- Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7Chai An Mao
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Development 140:541-51. 2013..The results indicate that Atoh7 and Neurod1 activate distinct sets of genes in vivo, despite their common DNA-binding element...
- Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptorsMichael S Fleming
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
elife 4:e06828. 2015..Taken together, our results suggest that trans and cis RET signaling could function in the same developmental process and that the availability of both forms of activation likely enhances but not diversifies outcomes of RET signaling. ..
- Schwann cell myelination requires integration of laminin activitiesKaren K McKee
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Cell Sci 125:4609-19. 2012....
- WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersJesse Rinehart
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 286:30171-80. 2011..These findings suggest a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling...
- Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathwayThomas M Coate
Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 73:49-63. 2012..These results indicate a model whereby Pou3f4 in the otic mesenchyme establishes an Eph/ephrin-mediated fasciculation signal that promotes inner radial bundle formation...
- Distribution of protocadherin 9 protein in the developing mouse nervous systemH Asahina
Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Okoh cho, Nankoku City, Kochi 783 8505, Japan
Neuroscience 225:88-104. 2012..In the dorsal root ganglion, only certain subsets of neurons showed Pcdh9 immunoreactivity. These results suggest that Pcdh9 might be involved in formation of specific neural circuits during neural development...
- NCAM in the organ of Corti of the developing mouseD S Whitlon
Department of Neurology, University of Wisconsin, Madison
J Neurocytol 19:970-7. 1990..NCAM is also present along the growth path of the nerve fibres. These studies suggest that NCAM is properly positioned in the cochlea for possible roles in axon guidance and nerve-target interactions...
- Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cellsD Balomenos
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 155:3308-12. 1995..These findings may have important implications for TCR selection and specificity, age-related repertoire changes, and autoimmune disease pathogenesis...
- Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous systemJ Dahlstrand
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
Brain Res Dev Brain Res 84:109-29. 1995....
- Amyotrophic lateral sclerosis: recent insights from genetics and transgenic miceR H Brown
Cecil B Day Laboratory for Neuromuscular Research Neurology Service, Massachusetts General Hospital, Boston 02114
Cell 80:687-92. 1995
- Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbsT Kitsukawa
Department of Molecular Biology, School of Science, Nagoya University, Japan
Development 121:4309-18. 1995..Correct spatiotemporal expression of neuropilin seems to be essential for normal development of the cardiovascular system, nervous system and limbs...
- POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cellsL Gan
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Proc Natl Acad Sci U S A 93:3920-5. 1996..In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types...
- Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cellsC W Lo
Biology Department, University of Pennsylvania, Philadelphia, USA
Dev Genet 20:119-32. 1997..1995], a region of the heart in which neural crest cells are required for normal development...
- Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in transfected cellsN P Bajaj
Department of Neurology, Institute of Psychiatry, London, England, U K
J Neurochem 69:737-43. 1997..Using the transfected fragments, we also map the epitopes for several commonly utilised NF-H monoclonal antibodies and describe the effects that phosphorylation by cdk-5 and GSK-3alpha have on their reactivities...
- The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neuronsC L Leung
Departments of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York 10032, USA
J Cell Biol 144:435-46. 1999..Since peripherin and BPAG1-n also display similar expression patterns in the nervous system, we suggest that peripherin is the specific interaction partner of BPAG1-n in vivo...
- The cytoskeleton of the myenteric neurons during murine embryonic lifeM S Faussone-Pellegrini
Department of Human Anatomy and Histology, University of Florence, Italy
Anat Embryol (Berl) 199:459-69. 1999....
- Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transportM Setou
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Science 288:1796-802. 2000..This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis...
- An amphioxus Emx homeobox gene reveals duplication during vertebrate evolutionN A Williams
School of Animal and Microbial Sciences, University of Reading, Reading, England
Mol Biol Evol 17:1520-8. 2000..Finally, our molecular phylogenetic analysis strongly supports the presence of a single Emx gene in the ancestor of chordates and gene duplication along the vertebrate lineage...
- The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neuronsR Sakai
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
Neuron 28:819-33. 2000..The results indicate that these Shc family members possess both unique and overlapping functions in regulating neural development and suggest physiological roles for ShcB/ShcC in TrkA signaling...
- Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilamentsT Ishihara
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 21:6026-35. 2001..tau (T44) Tg mice overexpressing the smallest human tau isoform with knock-out mice devoid of NFL (NFL-/-) or NFH (NFH-/-). Depletion of NF subunit proteins from the T44 mice (i.e...
- Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual systemAndrew S Plump
Department of Anatomy, Howard Hughes Medical Institute, CA, USA
Neuron 33:219-32. 2002..Our results indicate that Slit proteins repel retinal axons in vivo and cooperate to establish a corridor through which the axons are channeled, thereby helping define the site in the ventral diencephalon where the optic chiasm forms...
- Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkCKatharine M Cronk
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Development 129:3739-50. 2002..Therefore, truncated trkC plays a more important role in the development of this innervation than kinase forms of trkA or trkC or of NT3, the only known ligand for trkC receptors...
- Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferaseThomas Misgeld
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 36:635-48. 2002..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
- BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system developmentKarin Agerman
Unit of Molecular Neurobiology, MBB, Karolinska Institutet, 171 77 Stockholm, Sweden
Development 130:1479-91. 2003....
- Neuromuscular synapses mediate motor axon branching and motoneuron survival during the embryonic period of programmed cell deathGlen B Banks
School of Biomedical Sciences, Department of Physiology and Pharmacology and SRC for Bio informatics and Applied Genomics, University of Queensland, 4072, St Lucia, Queensland, Australia
Dev Biol 257:71-84. 2003..Thus, agrin-induced synaptic specializations are required for skeletal muscle to effectively control motoneuron numbers during embryonic development...
- Schwann cells synthesize alpha7beta1 integrin which is dispensable for peripheral nerve development and myelinationS C Previtali
Neuropathology Unit, San Raffaele Scientific Institute, Milan, Italy
Mol Cell Neurosci 23:210-8. 2003..Nonetheless, these data taken together with the previous demonstration of impaired axonal regrowth in alpha7-null mice suggest a possible Schwann cell-autonomous role for alpha7 in nerve regeneration...
- Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn miceRobert W Burgess
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Mol Cell Biol 24:1096-105. 2004..elegans, we propose that Phr1 plays a conserved role in synaptic development and is a candidate gene for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing...
- The toppler mouse: a novel mutant exhibiting loss of Purkinje cellsCynthia S Duchala
Department of Neurosciences, The Lerner Research Institute, NC30, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Comp Neurol 476:113-29. 2004..Given the changes in both Purkinje cells and glia in toppler cerebellum, this may be a very useful model in which to investigate the developmental interaction of Purkinje cells and Bergmann glia...
- The invulnerability of adult neurons: a critical role for p73Gregory S Walsh
Developmental Biology and Cancer Research, Hospital for Sick Children, Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
J Neurosci 24:9638-47. 2004..Thus, one way adult neurons become invulnerable is to enhance endogenous survival pathways, and one critical component of these survival pathways is p73...
- Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesisLing Pan
Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
Development 132:703-12. 2005..These results indicate that Brn3 factors are functionally equal and that their unique roles in neurogenesis are determined by the distinctive Brn3 spatiotemporal expression patterns...
- Phosphorylation of c-Jun in avian and mammalian motoneurons in vivo during programmed cell death: an early reversible event in the apoptotic cascadeWoong Sun
Department of Anatomy, College of Medicine, Brain Korea 21, Korea University, Sungbuk Gu, Seoul, Korea 136 705
J Neurosci 25:5595-603. 2005..Together, c-Jun phosphorylation appears to be required for the initiation of an early and reversible event in the intracellular PCD cascade in vivo after loss of survival-promoting signals such as neurotrophic factors...
- Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellumMikio Hoshino
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Neuron 47:201-13. 2005..Our results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum...
- Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficitsDiane M Jaworski
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, 05405, USA
J Neurobiol 66:82-94. 2006..The tissue specificity of the nerve branching phenotype suggests the involvement of different MMPs and/or extracellular matrix molecules underlying the TIMP-2(-/-) motor phenotype...
- The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: inhibition by phosphorylation of the high molecular weight subunitCheolwha Jung
Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts, Lowell, One University Avenue, Lowell, MA 01854, USA
Brain Res Mol Brain Res 141:151-5. 2005..They further indicate that phosphorylation of NF-H dissociates NFs from kinesin and provides a mechanism by which NF-H phosphorylation can contribute to the slowing of NF axonal transport...
- Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of miceWenxue Tang
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 26:1991-9. 2006..Our findings demonstrated the requirement of Cx29 for normal cochlear functions and suggest that Cx29 is a new candidate gene for studying the auditory neuropathy...
- FAK is required for axonal sorting by Schwann cellsMatthew Grove
Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, Scotland, UK
J Cell Biol 176:277-82. 2007..These findings demonstrate the vital relationship between axon defasciculation and Schwann cell number and show the importance of FAK in regulating cell proliferation in the developing nervous system...
- Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitorsMladen Roko Rasin
Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Nat Neurosci 10:819-27. 2007..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex...
- Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafishFrancois Gros-Louis
Department of Medicine, Center for Excellence in Neuromics, CHUM Research Center, University of Montreal, Montreal, QC, Canada
Hum Mol Genet 17:2691-702. 2008..Thus, we speculate that the newly identified Als2 mRNA species prevent the Als2 KO mice from developing severe neurodegenerative disease and might also regulate the severity of the motor neurons phenotype observed in ALS2 patients...
- The EGFR is required for proper innervation to the skinAdel Maklad
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
J Invest Dermatol 129:690-8. 2009..These data demonstrate that EGFR is required for proper cutaneous innervation during development and suggest that it limits axonal outgrowth and branching in a DRG-autonomous manner...
- Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortexAlessandro Sessa
Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Neuron 60:56-69. 2008..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
- RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genesGee Y Ching
Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Neurochem 109:1610-23. 2009..Thus, REST regulates expression of these neuronal genes, partly by a HDAC-dependent epigenetic mechanism...
- Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulationSerge A van de Pavert
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Nat Immunol 10:1193-9. 2009..Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons...
- Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brainDmitry Goryunov
Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, NY, NY 10032, USA
Mol Cell Neurosci 44:1-14. 2010..Embryonic neurons showed a defect in traversing the cortical plate. Our data suggest a critical role for MACF1 in neuronal migration that is dependent on its ability to interact with both microfilaments and microtubules...
- Molecular Regulation of TIMP-2 in Neuron Cell CycleDIANE JAWORSKI; Fiscal Year: 2007..abstract_text> ..