Myl9

Summary

Gene Symbol: Myl9
Description: myosin, light polypeptide 9, regulatory
Alias: AI327049, MLC20, Mylc2c, RLC-C, myosin regulatory light polypeptide 9, myosin light chain, regulatory C, myosin regulatory light chain 2, smooth muscle isoform, myosin regulatory light chain 9
Species: mouse

Top Publications

  1. pmc Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor
    Zekuan Lu
    From the Group of Cell Motility and Muscle Contraction, National Laboratory of Integrated Management of Insect Pests and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101 and
    J Biol Chem 289:18535-48. 2014
  2. pmc Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains
    Joaquim Grego-Bessa
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Development 142:1305-14. 2015
  3. doi Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice
    Qiu Xia Liang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    Biol Reprod 92:97. 2015
  4. pmc Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex
    Oriana S Fisher
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Commun 6:7937. 2015
  5. pmc Pdx1 regulates pancreas tubulogenesis and E-cadherin expression
    Leilani Marty-Santos
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 143:101-12. 2016
  6. ncbi Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis
    S W Kubalak
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    J Biol Chem 269:16961-70. 1994
  7. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997
  8. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
  9. ncbi Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
    D Srivastava
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Nat Genet 16:154-60. 1997
  10. pmc Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel
    B Vannier
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:2060-4. 1999

Scientific Experts

  • Xuefei Ma
  • D Srivastava
  • Leilani Marty-Santos
  • Joaquim Grego-Bessa
  • Qiu Xia Liang
  • Oriana S Fisher
  • Zekuan Lu
  • Inju Park
  • Xiao Sheng Jiang
  • Eloi Montanez
  • Aram F Hezel
  • Yoshihiko Shimizu
  • Ondine Cleaver
  • Dou Liu
  • Heide Schatten
  • Qing Yuan Sun
  • Zhen Bo Wang
  • Shu Tao Qi
  • Angeliki Louvi
  • Rong Wei
  • Bing Su
  • Kathryn V Anderson
  • Zhong Wei Wang
  • Hanqiang Deng
  • Jeffrey Hildebrand
  • Benjamin E Turk
  • Fan Zhang
  • Meng Wen Hu
  • Ya Zhang
  • Titus J Boggon
  • Qing Hua Zhang
  • Min Sheng Zhu
  • Yong Deng
  • Jie Zhang
  • Hai Man Zhang
  • Yujie Sun
  • Xiang Dong Li
  • Hao Ding
  • Huan Hong Ji
  • Dan Luo
  • Woo Jin Park
  • Do Han Kim
  • Boyeon Lee
  • Zee Yong Park
  • Heejin Choi
  • Chunghee Cho
  • Cecil Han
  • Jihye Kim
  • Ekaterina Lifirsu
  • Dongwook Kim
  • Jun Tae Kwon
  • Sora Jin
  • Alfred L Yergey
  • Christopher A Wassif
  • Zheng Li
  • Lynne A Holtzclaw
  • Li Song
  • Forbes D Porter
  • Peter S Backlund
  • Reinhard Fassler
  • Haiyan Chu
  • Sara A Wickström
  • Johannes Altstätter
  • Avital Swisa
  • Yuval Dor
  • Sushma Gurumurthy
  • Zvi Granot
  • Gerald Bailey
  • Ronald A Depinho
  • B Vannier
  • Gerry C Chu
  • Nabeel Bardeesy
  • Makoto M Taketo
  • Shuh Narumiya
  • Fumio Matsumura
  • Dean Thumkeo
  • Hiroko Oshima
  • Masanobu Oshima
  • Jeongsin Keel
  • Toshimasa Ishizaki
  • Yoichi Noda
  • C T Kuo
  • J D Molkentin
  • M Jiang
  • L Birnbaumer
  • N Qin
  • X Zhu
  • M Peyton
  • G Boulay
  • D Brown

Detail Information

Publications16

  1. pmc Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor
    Zekuan Lu
    From the Group of Cell Motility and Muscle Contraction, National Laboratory of Integrated Management of Insect Pests and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101 and
    J Biol Chem 289:18535-48. 2014
    ..Based on the above results, we concluded that Myo19 is a high-duty ratio molecular motor moving to the plus-end of the actin filament. ..
  2. pmc Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains
    Joaquim Grego-Bessa
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Development 142:1305-14. 2015
    ..The basal accumulation of F-actin is associated with the assembly of ectopic basal tight junctions and focal disruptions of the basement membrane, which eventually lead to a breakdown of epithelial organization...
  3. doi Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice
    Qiu Xia Liang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    Biol Reprod 92:97. 2015
    ..Our findings provide evidence that MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation. ..
  4. pmc Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex
    Oriana S Fisher
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Commun 6:7937. 2015
    ..We conclude that CCM2:MEKK3-mediated regulation of Rho signalling is required for maintenance of neurovascular integrity, unravelling a mechanism by which CCM2 loss leads to disease. ..
  5. pmc Pdx1 regulates pancreas tubulogenesis and E-cadherin expression
    Leilani Marty-Santos
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 143:101-12. 2016
    ..These findings demonstrate a novel link between regulators of epithelial architecture, specification of pancreatic cell fate and organogenesis. ..
  6. ncbi Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis
    S W Kubalak
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    J Biol Chem 269:16961-70. 1994
    ..The region-specific expression of the MLC-2a and MLC-2v genes in their respective chambers during early cardiogenesis provides genetic markers for chamber specification (atrial and ventricular) in both the in vitro and in vivo context...
  7. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997
    ..However, they define a critical role for GATA4 in regulating the rostral-to-caudal and lateral-to-ventral folding of the embryo that is needed for normal cardiac morphogenesis...
  8. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  9. ncbi Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
    D Srivastava
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Nat Genet 16:154-60. 1997
    ....
  10. pmc Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel
    B Vannier
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:2060-4. 1999
    ..e., classical CCE. The findings support the general hypothesis that Trp proteins are subunits of store- and receptor-operated Ca2+ channels...
  11. pmc ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    Yoshihiko Shimizu
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 168:941-53. 2005
    ..These results suggest that ROCK-I regulates closure of the eyelids and ventral body wall through organization of actomyosin bundles...
  12. pmc Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Mol Biol Cell 18:2305-12. 2007
    ..These studies show that the scaffolding properties of NM II-B play an important role in cell adhesion, thereby preventing hydrocephalus during mouse brain development...
  13. pmc Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    Aram F Hezel
    MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 28:2414-25. 2008
    ..These genetic studies provide in vivo evidence of a key role for LKB1 in the establishment of epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for the suppression of neoplasia...
  14. pmc Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 28:3132-44. 2009
    ..Our findings show that alpha-pv represents an essential adhesion checkpoint that controls RhoA/ROCK-mediated contractility in vSMCs...
  15. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention...
  16. doi Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity
    Inju Park
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    Biochem J 434:171-80. 2011
    ..highly conserved non-muscle RLCs of the mouse: MYL (myosin light chain) 12A (referred to as MYL12A), MYL12B and MYL9 (MYL12A/12B/9)...