Myh8

Summary

Gene Symbol: Myh8
Description: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Alias: 4832426G23Rik, AI327267, MHCp, MyHC-pn, Myhs-p, Myhsp, myosin-8, Beta-MHC antisense, myHC-perinatal, myosin heavy chain 8, myosin heavy chain, skeletal muscle, perinatal
Species: mouse

Top Publications

  1. ncbi Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro
    A Weydert
    Cell 49:121-9. 1987
  2. pmc Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation
    Ke He
    From the Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China
    J Biol Chem 292:351-360. 2017
  3. doi Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1
    Harika Nagandla
    Department of Biology and Biochemistry, University of Houston, Houston, TX, USA
    Dev Biol 410:86-97. 2016
  4. doi The FgfrL1 receptor is required for development of slow muscle fibers
    Ruth Amann
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 394:228-41. 2014
  5. doi A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
    Nissrine Daou
    Centre d Etude de la Sensori Motricité, UMR 8194 CNRS, Universite Paris Descartes, Centre Universitaire des Saints Peres, 45 Rue des Saints Peres, F 75270 Paris Cedex 06, France
    Development 140:4914-25. 2013
  6. pmc Calpain-6 deficiency promotes skeletal muscle development and regeneration
    Kazuo Tonami
    Calpain Project, Department of Advanced Science for Biomolecules, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya Ku, Tokyo, Japan
    PLoS Genet 9:e1003668. 2013
  7. pmc During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
    Shenhav Cohen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:1083-95. 2009
  8. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
  9. doi DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death
    Anne T Bertrand
    INSERM, UMRS_974, Paris F 75013, France
    Hum Mol Genet 21:1037-48. 2012
  10. doi Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics
    Annalisa Lamberti
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S Pansini 5, I 80131 Naples, Italy
    Biochimie 93:1738-46. 2011

Scientific Experts

  • Ke He
  • Harika Nagandla
  • Ruth Amann
  • Nissrine Daou
  • Kazuo Tonami
  • Paul Delgado-Olguín
  • Anne T Bertrand
  • Annalisa Lamberti
  • Shenhav Cohen
  • Briana K Dennehey
  • Nobuko Hagiwara
  • Junjie Gu
  • Sheng Li
  • Ping Hu
  • Hongye Wang
  • Ying Jin
  • Jing Hu
  • Hongyao Yu
  • Fan Tang
  • Laixiang Ge
  • Lina Wang
  • Robert J Schwartz
  • Haley O Tucker
  • Tara L Rasmussen
  • M David Stewart
  • Suhujey Lopez
  • Wei Yu
  • A Usami
  • Stefan Wyder
  • Beat Trueb
  • Anne M Slavotinek
  • Frederic Charbonnier
  • J L Vivian
  • Suzie Lefebvre
  • Yasuko Ono
  • Tomokazu Amano
  • Yumiko Kawamura
  • Sylvie Lecolle
  • Anne Sophie Armand
  • Takahiro Sato
  • Hiroyuki Sorimachi
  • Shoji Hata
  • Christophe Chanoine
  • Koichi Ojima
  • Hiroki Kurihara
  • Yukiko Kurihara
  • Bruno Della Gaspera
  • Alexander Tarakhovsky
  • Catherine Massart
  • Lucie Carrier
  • Aurélie Papadopoulos
  • J G Seidman
  • Marie Elodie Cattin
  • Marie Malissen
  • Chris Ottolenghi
  • Sophia Maron
  • Yu Huang
  • Danos Christodoulou
  • Benoit G Bruneau
  • Gisele Bonne
  • Christine E Seidman
  • Xue Li
  • Laure Renou
  • Valérie Decostre
  • Saskia Schlossarek
  • Takuro Arimura
  • Emmanuelle Lacene
  • Maud Beuvin
  • Ferdinando Papale
  • Carmen Sanges
  • Antimo Di Maro
  • Michele Caraglia
  • Paolo Arcari
  • Angela Chambery
  • Nunzia Migliaccio
  • Alberto Abbruzzese
  • Francesco Rosso
  • Augusto Parente
  • Monica Marra
  • T Sun
  • B Kablar
  • M Ontell
  • Alfred L Goldberg
  • David J Glass
  • Jeffrey J Brault
  • Esther Latres
  • Steven P Gygi
  • Carlos Gartner
  • David M Valenzuela
  • B D Lu

Detail Information

Publications31

  1. ncbi Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro
    A Weydert
    Cell 49:121-9. 1987
    ..In vitro, in the absence of the nerve, embryonic, perinatal, and adult IIB MHC mRNAs accumulate. The level of the latter two isomRNAs is influenced by culture conditions...
  2. pmc Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation
    Ke He
    From the Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China
    J Biol Chem 292:351-360. 2017
    ..Together, our study reveals that Stk40 is required for fetal skeletal muscle development and provides molecular insights into the control of the HDAC5-MEF2 axis in skeletal myogenesis...
  3. doi Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1
    Harika Nagandla
    Department of Biology and Biochemistry, University of Houston, Houston, TX, USA
    Dev Biol 410:86-97. 2016
    ..Thus, in addition to the previously described functions for Smyd1 in heart development and skeletal muscle sarcomerogenesis, these results point to a novel role for Smyd1 in myoblast differentiation. ..
  4. doi The FgfrL1 receptor is required for development of slow muscle fibers
    Ruth Amann
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 394:228-41. 2014
    ..to the slow fibers, fast fibers do not appear to be affected as shown by expression of fast fiber markers Myh3, Myh8, Myl1 and MylPF. At early developmental stages (E10.5, E15...
  5. doi A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
    Nissrine Daou
    Centre d Etude de la Sensori Motricité, UMR 8194 CNRS, Universite Paris Descartes, Centre Universitaire des Saints Peres, 45 Rue des Saints Peres, F 75270 Paris Cedex 06, France
    Development 140:4914-25. 2013
    ..Altogether, our findings demonstrate that the calcineurin/NFAT pathway plays a new role in establishing the early muscle fiber type in immature myofibers during embryogenesis. ..
  6. pmc Calpain-6 deficiency promotes skeletal muscle development and regeneration
    Kazuo Tonami
    Calpain Project, Department of Advanced Science for Biomolecules, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya Ku, Tokyo, Japan
    PLoS Genet 9:e1003668. 2013
    ....
  7. pmc During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
    Shenhav Cohen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:1083-95. 2009
    ..Because these proteins stabilize the thick filament, their selective ubiquitylation may facilitate thick filament disassembly. However, the thin filament components decreased by a mechanism not requiring MuRF1...
  8. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
    ..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
  9. doi DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death
    Anne T Bertrand
    INSERM, UMRS_974, Paris F 75013, France
    Hum Mol Genet 21:1037-48. 2012
    ..And importantly, L-CMD patients should be investigated for putative metabolic disorders...
  10. doi Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics
    Annalisa Lamberti
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S Pansini 5, I 80131 Naples, Italy
    Biochimie 93:1738-46. 2011
    ..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes...
  11. ncbi Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts
    Briana K Dennehey
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Muscle Res Cell Motil 27:559-75. 2006
    ..These findings indicate that alternative TSS usage and alternative splicing in the 5'-UTR are a general feature of murine Myh gene expression and that Myh gene regulation is more complex than previously appreciated...
  12. pmc Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved
    A Weiss
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 96:2958-63. 1999
    ....
  13. ncbi Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H
    Nobuko Hagiwara
    University of California, Davis, Division of Cardiovascular Medicine, Rowe Program in Genetics, Davis, CA 95616, USA
    Dev Dyn 234:301-11. 2005
    ..Together with our earlier report, demonstrating early postnatal muscle defects in the Sox6 null-p100H mutant, the present results suggest that Sox6 likely plays an important role in muscle development...
  14. ncbi Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development
    A Usami
    Department of Anatomy, Oral Health Science Center, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba City, Chiba, Japan
    Anat Histol Embryol 32:244-8. 2003
    ..In the compositional change of isoforms, the embryonic type MHCp was expressed consistently, whereas the adult isoforms increased with the developmental process...
  15. ncbi A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth
    T Sun
    Wolfson Institute for Biomedical Research and Department of Biology, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Development 127:4519-29. 2000
    ..In addition, we found that the YAC transgene did not prolong survival of Patch mutant mice, indicating that genetic defects outside the PDGFRalpha locus contribute to the early embryonic lethality of Patch mice...
  16. ncbi Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent
    B Kablar
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Development 127:1627-39. 2000
    ..Taken together, these results indicate that transdifferentiation is the fate of all smooth muscle cells in the upper esophagus and is normally initiated by Myf5...
  17. ncbi Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development
    B D Lu
    Department of Microbiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 216:312-26. 1999
    ..The changes in MyHC RNA and protein expression are distinct in different muscles and are restricted in some cases to particular regions of the muscle and do not always reflect their distribution in the adult...
  18. ncbi Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart
    J H Miner
    Division of Biology, California Institute of Technology, Pasadena 91125
    Development 114:853-60. 1992
    ....
  19. ncbi A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation
    J L Vivian
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Biol 208:44-55. 1999
    ....
  20. ncbi Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice
    N E Block
    Neuromuscular Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
    Dev Dyn 207:382-94. 1996
    ..MRF function, therefore, appears to be differentially regulated in dermatomal and myotomal cells...
  21. ncbi The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis
    F Zappelli
    Institute of Histology and General Embryology, University of Rome La Sapienza, Italy
    Dev Biol 180:156-64. 1996
    ..They also suggest a specific role for protein kinase C theta in determining the fate of different myoblasts during muscle histogenesis...
  22. ncbi Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles
    M Ontell
    Department of Neurobiology, Anatomy and Cell Science, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Development 117:1435-44. 1993
    ..These differences indicate that there is no single coordinate pattern of expression of contractile protein genes during initial formation of the muscles of the mouse.(ABSTRACT TRUNCATED AT 400 WORDS)..
  23. ncbi Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity
    M P Ontell
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Dev Dyn 198:203-13. 1993
    ..abstract truncated at 400 words)..
  24. ncbi Muscle-specific gene expression during myogenesis in the mouse
    M Ontell
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Microsc Res Tech 30:354-65. 1995
    ..The differences in gene expression in these two types of muscle suggest that no single coordinated pattern of gene activation is required during the initial formation of the muscles of the mouse...
  25. ncbi Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome
    A Patapoutian
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Development 121:3347-58. 1995
    ..Finally, a later and relatively mild phenotype was detected in intercostal muscles of newborn animals...
  26. pmc Myogenin is required for late but not early aspects of myogenesis during mouse development
    J M Venuti
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Cell Biol 128:563-76. 1995
    ....
  27. ncbi Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle
    A Weydert
    J Biol Chem 258:13867-74. 1983
    ..There is thus a rapid transition after birth from fetal to adult skeletal muscle myosin heavy chain mRNA sequences...
  28. pmc Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene
    A Weydert
    Proc Natl Acad Sci U S A 82:7183-7. 1985
    ..This result is in contrast to that for other contractile protein genes such as the alkali myosin light chain and the actin multigene families, which are dispersed in the genome...
  29. pmc The expression of myosin genes in developing skeletal muscle in the mouse embryo
    G E Lyons
    Department of Molecular Biology, U R A CNRS 1148, Pasteur Institute, Paris, France
    J Cell Biol 111:1465-76. 1990
    ..The data presented are the first detailed study of myosin gene expression at these early stages of skeletal muscle development...
  30. ncbi Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line
    R D Cox
    Department of Molecular Biology, Pasteur Institute, CNRS UA 1148, Paris, France
    Dev Biol 143:36-43. 1991
    ..Post-transcriptional mechanisms also regulate cytoplasmic RNA accumulation of these MHC genes...
  31. ncbi Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro
    T H Smith
    Day Neuromuscular Laboratory, Massachusetts General Hospital, Charlestown 02129
    Dev Biol 149:16-26. 1992
    ..Thus, the myogenic program of fetal, but not embryonic, mouse myogenic cells includes expression of the perinatal MHC isoform upon differentiation in culture...