Mycn

Summary

Gene Symbol: Mycn
Description: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
Alias: N-myc, Nmyc, Nmyc-1, Nmyc1, bHLHe37, c-nmyc, N-myc proto-oncogene protein, neuroblastoma myc-related oncogene 1, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
Species: mouse

Top Publications

  1. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
  2. ncbi Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    B R Stanton
    Molecular Embryology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genes Dev 6:2235-47. 1992
  3. ncbi Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene
    J Charron
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genes Dev 6:2248-57. 1992
  4. ncbi A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung
    C B Moens
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 6:691-704. 1992
  5. ncbi Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo
    K M Downs
    Department of Microbiology and Immunology, University of California San Francisco 94143
    Genes Dev 3:860-9. 1989
  6. pmc N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization
    G Mugrauer
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:1325-35. 1988
  7. ncbi Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse
    S Sawai
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    Development 117:1445-55. 1993
  8. pmc Expression and activity of L-Myc in normal mouse development
    K S Hatton
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 16:1794-804. 1996
  9. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
  10. ncbi Transgenic N-myc mouse model for indolent B cell lymphoma: tumor characterization and analysis of genetic alterations in spontaneous and retrovirally accelerated tumors
    R D Sheppard
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Oncogene 17:2073-85. 1998

Research Grants

  1. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
  2. New Directions in Mutagenized ES Cell Libraries
    Andras Nagy; Fiscal Year: 2003
  3. GENETIC DETERMINATION OF ACUTE LUNG INJURY
    GEORGE LEIKAUF; Fiscal Year: 2004
  4. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
  5. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
  6. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
  7. Contribution to the completion of Comprehensive Mouse Knockout Resource
    Andras Nagy; Fiscal Year: 2008
  8. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010

Scientific Experts

  • Ahmed H K El-Hashash
  • K Kobayashi
  • Fredrik J Swartling
  • WILLIAM TSWENCHING PU
  • GEORGE DOUGLAS LEIKAUF
  • Benjamin Kopecky
  • James Wells
  • Jean Charron
  • Andras Nagy
  • Louis Chesler
  • Derk ten Berge
  • Shao Ling Zhang
  • D P Cerretti
  • A Trumpp
  • Paul S Knoepfler
  • Robert N Eisenman
  • Zi Qiang Zhou
  • Anna Marie Kenney
  • Victor Vendrell
  • Edward E Morrisey
  • Ashley M Goss
  • Sara Ota
  • David H Rowitch
  • Roberta Scognamiglio
  • Frederique Zindy
  • Bret C Mobley
  • Dimitris Karamitros
  • Min Min Lu
  • Matias Alvarez-Saavedra
  • Christopher S Hackett
  • Tadashi Okubo
  • Pei Feng Cheng
  • Yong Wang
  • Iris López-Hernández
  • Thomas Schimmang
  • Ruilin Sun
  • Francesco Neri
  • Madeline A Lancaster
  • Leah E Colvin Wanshura
  • Elena Dominguez-Frutos
  • Kazuhito Toyo-oka
  • Eric Potvin
  • Keriayn N Smith
  • Natalia V Varlakhanova
  • Anthony P Popkie
  • Florian Witte
  • W D Thomas
  • Peter J Hurlin
  • Xudong Zhao
  • Jessica D Kessler
  • Claire Bonal
  • Jennifer A Chan
  • Ethan David Cohen
  • Hye Yeong Ha
  • Yun Wen Chen
  • T Sanosaka
  • Nicole C Dubois
  • Yongjun Yin
  • Yuzhen Zhang
  • Rodrigo A P Martins
  • Elisa Laurenti
  • Armin Ehninger
  • Hiroyuki Kawagoe
  • Nobutaka Koibuchi
  • Brian Cox
  • Yun Lu
  • Samantha A Brugmann
  • Martine F Roussel
  • Jeffrey A Whitsett
  • Jin Wen Chen
  • Beryl A Hatton
  • Robert J Wechsler-Reya
  • Miwako Kobayashi
  • Ming Chang Hu
  • Brigid L M Hogan
  • Valerie Horsley
  • Chen Leng Cai
  • Xiuqian Mu
  • Weiguo Shu
  • P J Hurlin
  • Dae Young Jung
  • Michael G Rosenfeld
  • Bin Wang
  • M Tanaka
  • Anthony Wynshaw-Boris
  • C Queva
  • Nina Cabezas-Wallscheid
  • Philipp Wörsdörfer
  • Austin Smith
  • Daniel B Campbell

Detail Information

Publications116 found, 100 shown here

  1. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  2. ncbi Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    B R Stanton
    Molecular Embryology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genes Dev 6:2235-47. 1992
    ..Examination of c-myc expression in mutant embryos indicates the existence of coordinate regulation of myc genes during mouse embryogenesis...
  3. ncbi Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene
    J Charron
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genes Dev 6:2248-57. 1992
    ..These results demonstrate that N-myc plays an essential role during development and clearly confirm that N-myc has a physiological function that is distinct from that of the other myc-family genes...
  4. ncbi A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung
    C B Moens
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 6:691-704. 1992
    ....
  5. ncbi Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo
    K M Downs
    Department of Microbiology and Immunology, University of California San Francisco 94143
    Genes Dev 3:860-9. 1989
    ..Instead, the gene appeared to be regulated in concert with changes that affect a diversity of cellular properties, including proliferation, invasiveness, and differentiation...
  6. pmc N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization
    G Mugrauer
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:1325-35. 1988
    ..The results raise the possibility that N-myc may participate in the control of these early differentiation events...
  7. ncbi Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse
    S Sawai
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    Development 117:1445-55. 1993
    ..The phenotype of N-myc-deficient mutant embryos indicated requirement of the N-myc function in many instances of tissue interactions in organogenesis and also in cell-autonomous regulation of tissue maturation...
  8. pmc Expression and activity of L-Myc in normal mouse development
    K S Hatton
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 16:1794-804. 1996
    ....
  9. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
    ..Taken together, our data suggest that the different members of the MAD protein family exert their functions at distinct steps during the transition between proliferation and differentiation...
  10. ncbi Transgenic N-myc mouse model for indolent B cell lymphoma: tumor characterization and analysis of genetic alterations in spontaneous and retrovirally accelerated tumors
    R D Sheppard
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Oncogene 17:2073-85. 1998
    ....
  11. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
    ..We propose that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size...
  12. pmc Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology and Bioinformatics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:7331-6. 2003
    ..Finally, cyclin D1 and N-myc are overexpressed in murine medulloblastoma. These findings suggest that cyclin D1 and N-myc are important mediators of Shh-induced proliferation and tumorigenesis...
  13. ncbi Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 131:217-28. 2004
    ..Shh signaling drives expression of mRNA encoding the Nmyc1 oncoprotein (previously N-myc), which is essential for expansion of cerebellar granule neuron precursors...
  14. ncbi Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:1363-74. 2005
    ..established that lung development is severely disrupted in mouse mutants with reduced levels of the proto-oncogene Nmyc, but the precise mechanisms involved have not been explored...
  15. pmc Myc influences global chromatin structure
    Paul S Knoepfler
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    EMBO J 25:2723-34. 2006
    ..This study provides the first evidence for regulation of global chromatin structure by an oncoprotein and may explain the broad effects of Myc on cell behavior and tumorigenesis...
  16. pmc N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development
    Frederique Zindy
    Department of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:11579-83. 2006
    ..These results provide definitive genetic evidence that expression of N-Myc and concomitant down-regulation of Ink4c and Kip1 contribute to the proper development of the cerebellum...
  17. pmc Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    Louis Chesler
    Department of Neurology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 66:8139-46. 2006
    Amplification of MYCN occurs commonly in neuroblastoma...
  18. ncbi N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Res 66:8655-61. 2006
    ....
  19. ncbi Activities of N-Myc in the developing limb link control of skeletal size with digit separation
    Sara Ota
    Shriners Hospitals for Children Portland, OR 97239, USA
    Development 134:1583-92. 2007
    ..Here, we show that conditional deletion of N-Myc (Mycn) in the developing mouse limb leads to uniformly small skeletal elements and profound soft-tissue syndactyly...
  20. ncbi Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice
    Hiroyuki Kawagoe
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 67:10677-85. 2007
    ..These results show that N-Myc overexpression is highly oncogenic in mouse myeloid cells and suggest that N-MYC up-regulation contributes to human myeloid leukemogenesis...
  21. pmc N-myc coordinates retinal growth with eye size during mouse development
    Rodrigo A P Martins
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Genes Dev 22:179-93. 2008
    ..We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues...
  22. pmc Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development
    Derk ten Berge
    Howard Hughes Medical Institute, Department of Developmental Biology, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 135:3247-57. 2008
    ....
  23. pmc Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity
    Elisa Laurenti
    Ecole Polytechnique Federale de Lausanne EPFL, ISREC, Swiss Institute for Experimental Cancer Research, School of Life Science, CH 1066 Epalinges, Switzerland
    Cell Stem Cell 3:611-24. 2008
    ..Collectively, Myc activity (c-Myc and N-Myc) controls crucial aspects of HSC function including proliferation, differentiation, and survival...
  24. doi Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression
    W D Thomas
    Children s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia
    Oncogene 28:1605-15. 2009
    ..Taken together our data identify N-Myc protein stability as the result of loss of Ptch1, which distinguishes normal cerebellar development from medulloblastoma tumorigenesis...
  25. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
    ..To identify common signaling abnormalities, we profiled mRNA, demonstrating misexpression of MYCN in the majority of human MB and negligible expression in normal cerebella...
  26. pmc myc maintains embryonic stem cell pluripotency and self-renewal
    Natalia V Varlakhanova
    Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Differentiation 80:9-19. 2010
    While endogenous Myc (c-myc) and Mycn (N-myc) have been reported to be separately dispensable for murine embryonic stem cell (mESC) function, myc greatly enhances induced pluripotent stem (iPS) cell formation and overexpressed c-myc ..
  27. pmc Myc represses primitive endoderm differentiation in pluripotent stem cells
    Keriayn N Smith
    Department of Biochemistry and Molecular Biology, Paul D Coverdell Center for Biomedical and Health Sciences, The University of Georgia, 500 D W Brooks Drive, Athens, GA 30602, USA
    Cell Stem Cell 7:343-54. 2010
    ..Our findings demonstrate the indispensable requirement for c- or N-myc in pluripotency beyond proliferative and metabolic control...
  28. pmc Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3
    Eric Potvin
    Centre de recherche en cancérologie de l Université Laval, 9 rue McMahon, Quebec, QC, Canada
    Mol Cell Biol 30:5348-63. 2010
    ..Together, these data demonstrate that correct N-myc developmental expression is achieved via cooperation of multiple positive and negative regulatory elements...
  29. pmc Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear
    Benjamin Kopecky
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    Dev Dyn 240:1373-90. 2011
    ..These findings are put in the context of the possible functional relationship of N-Myc with a number of other cell proliferative and fate determining genes during ear development...
  30. pmc N-myc controls proliferation, morphogenesis, and patterning of the inner ear
    Elena Dominguez-Frutos
    Institute of Biology and Molecular Genetics, University of Valladolid and Spanish National Research Council, E 47003 Valladolid, Spain
    J Neurosci 31:7178-89. 2011
    ..Collectively, our data suggest that N-myc regulates growth, morphogenesis, and pattern formation during the development of the inner ear...
  31. pmc Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    Fredrik J Swartling
    University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
    Cancer Cell 21:601-13. 2012
    The proto-oncogene MYCN is mis-expressed in various types of human brain tumors...
  32. ncbi Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes
    S Sawai
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    New Biol 3:861-9. 1991
    ..N-myc-null ES cells offer a valuable tool in chimera analysis to elucidate the requirement for N-myc function in embryogenesis...
  33. ncbi Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus
    C B Moens
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Development 119:485-99. 1993
    ..This study illustrates the importance of generating different mutations at a given locus to elucidate fully the function of a particular gene during development...
  34. pmc N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    Paul S Knoepfler
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 16:2699-712. 2002
    ..Its effects on proliferation and differentiation appear due, at least in part, to down-regulation of a specific subset of cyclin-dependent kinase inhibitors...
  35. ncbi Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 130:15-28. 2003
    ..We report that sonic hedgehog (Shh) signaling upregulates expression of the proto-oncogene Nmyc in cultured cerebellar granule neuron precursors (CGNPs) in the absence of new protein synthesis...
  36. ncbi A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis
    U Hirning
    Abteilung Klinische Genetik, Universitat Ulm, F R G
    Mech Dev 33:119-25. 1991
    ..g., during development of eye lens, retina, telencephalon and gut epithelium. Thus, in spite of the structural similarities of N-myc and c-myc genes and proteins their developmental expression patterns suggest different functional roles...
  37. ncbi Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development
    A D Domashenko
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Mol Reprod Dev 47:57-65. 1997
    ....
  38. ncbi Mutational analysis of transgenic mouse B cell lymphomas: indication of a Trp53-independent pathway in tumor progression
    S A Samant
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Leuk Res 23:939-46. 1999
    ..These findings suggested that disease progression in our novel murine lymphoma model may proceed via a Trp53-independent pathogenetic pathway...
  39. pmc Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development
    Zi Qiang Zhou
    Shriners Hospitals for Children Portland, Portland, Oregon, United States of America
    PLoS ONE 6:e18795. 2011
    ..The aim of this study was to gain insight into these processes by examining the roles of c-Myc and N-Myc in morphogenesis of the limb skeleton...
  40. pmc Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability
    Benjamin J Kopecky
    University of Iowa, Department of Biology, Iowa City, IA 52242, USA
    Dev Dyn 242:132-47. 2013
    ..The late-onset hair cell death in the absence of early N-Myc expression could be due to mis-regulation of genes necessary for neurosensory formation and maintenance, such as Neurod1, Atoh1, Pou4f3, and Barhl1...
  41. pmc Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation
    Matias Alvarez-Saavedra
    1 Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 2 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    Nat Commun 5:4181. 2014
    ..Our studies reveal that Snf2h controls chromatin organization and histone H1 dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation. ..
  42. pmc Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma
    Christopher S Hackett
    Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Rep 9:1034-46. 2014
    ..These results suggest that ARG1 and GABA influence both neural development and neuroblastoma and that benzodiazepines in clinical use may have potential applications for neuroblastoma therapy...
  43. doi Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors
    Dimitris Karamitros
    Department of Physiology, Medical School, University of Patras, Rio, Patras 26504, Greece
    Development 142:70-81. 2015
    ..Our data suggest that geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system. ..
  44. pmc Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis
    Bret C Mobley
    Department of Pathology, Microbiology, and Immunology, Division of Neuropathology, Vanderbilt University Medical Center, Nashville, Tennessee, The United States of America
    PLoS ONE 10:e0133897. 2015
    ..Amplification of the MYCN oncogene is a genetic marker of risk in this disease...
  45. pmc Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
    Roberta Scognamiglio
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI STEM gGmbH, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cell 164:668-80. 2016
    ..Our study shows that Myc controls the biosynthetic machinery of stem cells without affecting their potency, thus regulating their entry and exit from the dormant state. ..
  46. pmc Inducible and reversible regulation of endogenous gene in mouse
    Ruilin Sun
    Shanghai Research Center for Model Organisms, Shanghai 201210, People s Republic of China
    Nucleic Acids Res 40:e166. 2012
    ..a chimeric transcriptional repressor molecule (tTS) can reversibly inhibit the expression of an endogenous gene, Nmyc. In this system, a tetracycline response element (TRE) artificially inserted near the target gene's promoter region ..
  47. pmc Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells
    Francesco Neri
    Dipartimento di Biotecnologie Università di Siena, Siena, Italy
    Mol Cell Biol 32:840-51. 2012
    ..Thus, Myc proteins control the expression of developmental regulators via the upregulation of the Polycomb PRC2 complex...
  48. doi Roles of Wnt8a during formation and patterning of the mouse inner ear
    Victor Vendrell
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
    Mech Dev 130:160-8. 2013
    ..Further reduction of Wnt signalling by the inactivation of Wnt1 in a Wnt8a mutant background revealed a redundant requirement for both genes during morphogenesis of the dorsal portion of the otic vesicle...
  49. doi Transcription factor Sox11 is essential for both embryonic and adult neurogenesis
    Yong Wang
    School of Life Sciences, Arizona State University, Tempe, Arizona, USA
    Dev Dyn 242:638-53. 2013
    ..Although neurogenesis is fundamental to brain development and function, our understanding of the molecular mechanisms that regulate neurogenesis is still limited...
  50. pmc Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses
    D R Beier
    Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115
    Proc Natl Acad Sci U S A 89:9102-6. 1992
    ..These results were confirmed using single-strand conformation polymorphism analysis of an interspecific backcross...
  51. ncbi Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants
    B Mukherjee
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
    Genes Dev 6:1480-92. 1992
    ....
  52. pmc Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells
    B R Stanton
    Molecular Embryology Group, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201
    Mol Cell Biol 10:6755-8. 1990
    ..The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development...
  53. pmc Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
    X H Sun
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Mol Cell Biol 11:5603-11. 1991
    ..E47 and E2B.m3, but not that of the other set, including TFE3, USF, and AP4. The Id proteins also homodimerize poorly. Expression of both Id genes is down-regulated during differentiation in a variety of cell types...
  54. ncbi Chromosome localization and expression pattern of Lmyc and Bmyc in murine embryonal carcinoma cells
    S Ingvarsson
    Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden
    Oncogene 3:679-85. 1988
    ..vitro differentiation of the murine EC line F9 and considered the findings in relation to our previous studies on Nmyc and c-myc expression in the same line (Sejersen et al., 1987)...
  55. ncbi Chromosomal location of N-myc and L-myc genes in the mouse
    G R Campbell
    Department of Biochemistry, NYU Medical Center, New York 10016
    Oncogene Res 4:47-54. 1989
    ..The second locus in each pair may be a pseudogene...
  56. pmc Nucleotide sequence of the coding region of the mouse N-myc gene
    Y Taya
    EMBO J 5:1215-9. 1986
    ..A remarkable sequence containing 13 successive acidic amino acids is present in one of the conserved regions located in the middle of the N-myc protein...
  57. pmc Complete nucleotide sequence and exon-intron boundaries of the 5' non-coding region of the mouse N-myc gene
    K Katoh
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Nucleic Acids Res 16:3589. 1988
  58. ncbi Juxtaposition of N-myc and Ig kappa through a reciprocal t(6;12) translocation in a mouse plasmacytoma
    H Axelson
    Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 11:85-90. 1994
    ..Its tumorigenic influence would become manifest only at the time when the cell would normally be programmed to leave the cycling compartment, in connection with its terminal differentiation...
  59. ncbi Six loci mapped on to human chromosome 2p are assigned to sheep chromosome 3p
    T E Broad
    AgResearch Invermay Agricultural Centre, Mosgiel, New Zealand
    Anim Genet 26:85-90. 1995
    ..Therefore, we predict that the other loci assigned in this study to sheep 3p are likely to be located on cattle 11. The provisional assignment of an additional locus, annexin-like to sheep chromosome 3p is also reported...
  60. ncbi Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
    K Stark
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 372:679-83. 1994
    ..Thus, Wnt-4 appears to act as an autoinducer of the mesenchyme to epithelial transition that underlies nephron development...
  61. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  62. pmc Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells
    D H Gorski
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    Mol Cell Biol 13:3722-33. 1993
    ..The removal of serum from growing cells induced Gax expression fivefold within 24 h. These data suggest that Gax is likely to have a regulatory function in the G0-to-G1 transition of the cell cycle in vascular smooth muscle cells...
  63. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    EMBO J 14:5646-59. 1995
    ....
  64. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    EMBO J 15:2030. 1996
  65. ncbi Defective development of the embryonic liver in N-myc-deficient mice
    S Giroux
    Centre de recherche en cancérologie de l Université Laval, Quebec, Canada
    Dev Biol 195:16-28. 1998
    ....
  66. ncbi Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
    A Nagy
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Curr Biol 8:661-4. 1998
    ..This, and the possibility of subsequent lineage-specific or conditional allele repair in situ, represent new genome modification strategies that can be used to investigate multiple functions of a single gene...
  67. ncbi Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Neuron 21:1003-15. 1998
    ..Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3...
  68. ncbi The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
    M Tanaka
    Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Development 126:1269-80. 1999
    ..5 null cells exert dominant interfering effects on cardiac development, and (6) there were severe defects in yolk sac angiogenesis and hematopoiesis in the Csx/Nkx2.5 null embryos...
  69. ncbi Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25
    D P Cerretti
    Immunex Corporation, 51 University St, Seattle, WA, 98101, USA
    Cytokine 11:541-51. 1999
    ..The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25...
  70. ncbi FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium
    S G Tevosian
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 101:729-39. 2000
    ..Our findings provide the molecular inroad into the induction of coronary vasculature by myocardium in the developing heart...
  71. pmc Serotonin 2B receptor is required for heart development
    C G Nebigil
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Université L Pasteur de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 97:9508-13. 2000
    ..This mutation provides a genetic model for cardiopathy and should facilitate studies of both the pathogenesis and therapy of cardiac disorders in humans...
  72. ncbi Identification of N-myc regulatory regions involved in embryonic expression
    Jean Charron
    Center of Research on Cancer, University Laval, CHUQ, L Hôtel Dieu de Québec, Quebec, Quebec G1R 2J6, Canada
    Pediatr Res 51:48-56. 2002
    ..Altogether, these findings indicated that the regulation of the spatiotemporal expression pattern of N-myc during development necessitates multiple regulatory DNA elements...
  73. pmc Development of mice expressing a single D-type cyclin
    Maria A Ciemerych
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:3277-89. 2002
    ..Hence, the requirement for a particular cyclin in a given tissue is likely caused by specific transcription factors, rather than by unique properties of cyclins...
  74. pmc Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse
    Jessica Yingling
    Departments of Pediatrics and Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA
    Am J Hum Genet 73:475-88. 2003
  75. ncbi Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    Bin Wang
    Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 131:4477-87. 2004
    ....
  76. ncbi Pro-apoptotic activity of N-myc in activation-induced cell death of microglia
    Dae Young Jung
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurochem 94:249-56. 2005
    ....
  77. ncbi Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc
    Miwako Kobayashi
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheelesv 1, 171 77 Stockholm, Sweden
    Cell Tissue Res 323:81-90. 2006
    ....
  78. ncbi Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves
    Jin Wen Chen
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, USA
    Circ Res 98:923-30. 2006
    ..In addition, the results suggest that CAR-mediated intercellular contacts may regulate proliferation and differentiation of cardiomyocytes within the embryonic left ventricular wall...
  79. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
    ....
  80. pmc Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes
    Brian Cox
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Mol Syst Biol 3:109. 2007
    ..We also present an integrative analysis of mRNA and protein expression in Nmyc loss- and gain-of-function mutants...
  81. ncbi Wnt signaling mediates regional specification in the vertebrate face
    Samantha A Brugmann
    Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Development 134:3283-95. 2007
    ..Collectively, these data elucidate a new role for Wnt signaling in regional specification of the vertebrate face, and suggest possible mechanisms whereby species-specific facial features are generated...
  82. pmc Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
    Yun Lu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 310:442-53. 2007
    ..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells...
  83. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration...
  84. doi Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function
    Nicole C Dubois
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, School of Life Science, 1066 Epalinges, Switzerland
    Development 135:2455-65. 2008
    ....
  85. doi Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis
    Yun Wen Chen
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon Masson, Montreal, Quebec, H2W 1T7, Canada
    Pediatr Nephrol 23:1769-77. 2008
    ..Deficiency of AT(2)R may impair both Pax-2 and N-myc expression, eventually resulting in glomerular hyperfiltration that may, ultimately, lead to later development of hypertension...
  86. pmc N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma
    Jessica D Kessler
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 23:157-70. 2009
    ..These studies provide the first direct evidence that PNCs can give rise to tumors, and demonstrate that identification of genetic changes that promote tumor progression is critical for designing effective therapies for cancer...
  87. pmc Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses
    Jennifer A Chan
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 12:409-17. 2009
    ..Because activation of the Shh pathway is a feature of diverse human cancers, selective stimulation of proliferation by Shh-proteoglycan interactions may also figure prominently in neoplastic growth...
  88. pmc The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:210-21. 2009
    ..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors...
  89. pmc Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region
    Florian Witte
    Development and Disease Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 107:14211-6. 2010
    ....
  90. pmc Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci
    Anthony P Popkie
    Graduate Program in Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:41337-47. 2010
    ..Finally, we find that N-Myc is a potent Gsk-3-dependent regulator of Dnmt3a2 expression. In summary, we have identified a signal transduction pathway that is capable of altering the DNA methylation of imprinted loci...
  91. pmc Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome
    Madeline A Lancaster
    Laboratory for Neurogenetics, Howard Hughes Medical Institutes, Department of Pediatrics and Neurosciences, Institute for Genomic Medicine, University of California, San Diego, San Diego, California, USA
    Nat Med 17:726-31. 2011
    ..Our findings implicate a defect in Wnt signaling in the cerebellar midline phenotype seen in Joubert syndrome that can be overcome with Wnt stimulation...
  92. pmc Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells
    Leah E Colvin Wanshura
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Cancer Res 71:5336-45. 2011
    ....
  93. ncbi Tissue and age specific expression of the myc proto-oncogene family throughout the life span of the C57BL/6J mouse strain
    I Semsei
    Molecular Physiology and Genetics Section, National Institute on Aging, Baltimore, Maryland 21224
    Oncogene 4:465-71. 1989
    ....
  94. ncbi A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2
    D R Cox
    Department of Pediatrics, University of California, San Francisco 94143
    Cytogenet Cell Genet 48:92-4. 1988
    ..This assignment provides further evidence of genetic homoeology between a region of mouse chromosome 12 and the distal short arm of human chromosome 2...
  95. pmc Structure and expression of the murine N-myc gene
    R A DePinho
    Proc Natl Acad Sci U S A 83:1827-31. 1986
    ..We discuss these findings in the context of previously defined similarities and differences in the potential functional and regulatory aspects of these two myc-family members...
  96. ncbi Expression of N-myc in teratocarcinoma stem cells and mouse embryos
    A Jakobovits
    Nature 318:188-91. 1985
    ..Our data represent the first demonstration of expression of the N-myc gene in normal cells, and suggest that N-myc may be involved in mammalian embryogenesis...
  97. pmc N-myc can cooperate with ras to transform normal cells in culture
    G D Yancopoulos
    Proc Natl Acad Sci U S A 82:5455-9. 1985
    ..These results illustrate that N-myc does encode a c-myc-like transforming activity and that this transforming activity is not specific for the very restricted set of tumors in which N-myc is normally amplified or overexpressed...
  98. ncbi Notch1 is required for the coordinate segmentation of somites
    R A Conlon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 121:1533-45. 1995
    ..However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur...
  99. pmc Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo
    S D Morgenbesser
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
    EMBO J 14:743-56. 1995
    ..As a direct corollary, our data indicate that L-Myc and c-Myc are involved in distinct physiological processes in the same cell type...
  100. ncbi N-myc expression in the embryonic cochlea of the mouse
    R Romand
    Laboratoire de Neurobiologie et Physiologie du Developpement, Université Blaise Pascal Clermont II, Aubiere, France
    Hear Res 72:53-8. 1994
    ..This study shows that cochlear tissues derived from the otic placode present a significant level of N-myc transcript during late embryogenesis. N-myc expression seems to be related to cell differentiation in the inner ear...
  101. ncbi N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant
    A Shimono
    Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565, Japan
    Mech Dev 83:39-52. 1999
    ..The strategy we adopted in identifying target genes of a transcription factor should prove widely applicable when mutant animals are available...

Research Grants8

  1. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..The well-characterized mouse model generated by this proposal will be useful in the further understanding of the relationship between occupational exposures, genetic markers, inflammatory responses, and COPD. ..
  2. New Directions in Mutagenized ES Cell Libraries
    Andras Nagy; Fiscal Year: 2003
    ..Both strategies will be developed first in existing 129 ES cells, but will be transferred to newly derived C57BL/6 cell lines, as soon as they are validated, to provide mutations on the B6 'gold standard' background. ..
  3. GENETIC DETERMINATION OF ACUTE LUNG INJURY
    GEORGE LEIKAUF; Fiscal Year: 2004
    ..Significance: This investigation seeks to uncover novel genes not previously associated with survival during acute lung injury. Such findings could provide new biological information and insights into this severe clinical condition. ..
  4. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
    ..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
  5. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
    ..Determination of the relative roles of the genetic loci linked to nickel sulfate exposure is likely to improve our understanding of the mechanisms involved in acute lung injury. ..
  6. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  7. Contribution to the completion of Comprehensive Mouse Knockout Resource
    Andras Nagy; Fiscal Year: 2008
    ..This aspect will ensure the most cost effective methods are applied at each step along the way to completing the core goals of the KOMP. ..
  8. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..