Gene Symbol: Mup1
Description: major urinary protein 1
Alias: Ltn-1, Lvtn-1, Mup-1, Mup-a, Mup10, Mup7, Up-1, major urinary protein 1, MUP 1, major urinary protein 10, major urinary protein 7
Species: mouse

Top Publications

  1. ncbi Terminology for prealbumin loci in the house mouse
    F H Wilcox
    J Hered 67:113. 1976
  2. ncbi Linkage analysis of the murine interferon alpha locus (Ifa) on chromosome 4
    E De Maeyer
    J Hered 78:143-6. 1987
  3. ncbi Variation between mouse major urinary protein genes isolated from a single inbred line
    A J Clark
    Gene 18:221-30. 1982
  4. ncbi Biosynthesis of the major urinary proteins in mouse liver: a biochemical genetic study
    F G Berger
    Biochem Genet 19:1261-73. 1981
  5. pmc Ligand binding to protein-binding pockets with wet and dry regions
    Lingle Wang
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 108:1326-30. 2011
  6. pmc Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines
    B A Taylor
    J Virol 23:106-9. 1977
  7. ncbi Messenger RNAs coding for mouse major urinary proteins are differentially induced by testosterone
    P M Clissold
    Biochem Genet 22:379-87. 1984
  8. ncbi The gene family for major urinary proteins: expression in several secretory tissues of the mouse
    P H Shaw
    Cell 32:755-61. 1983
  9. pmc Sequence structures of a mouse major urinary protein gene and pseudogene compared
    A J Clark
    EMBO J 4:3159-65. 1985
  10. pmc Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation in the liver
    N J Kuhn
    Nucleic Acids Res 12:6073-90. 1984

Scientific Experts

  • D E Timm
  • Robert C Karn
  • Darren W Logan
  • Michael J Sheehan
  • Chin Chang Chen
  • Lingle Wang
  • Lori Vickerman
  • Xiaoyan Hui
  • Yingjiang Zhou
  • Vivian Kont
  • Tobias F Marton
  • Lisa Stowers
  • Pablo Chamero
  • Hiroko Kimoto
  • E Ferrari
  • Joseph A Baur
  • Richard J Bingham
  • C Lucke
  • F Abbate
  • Robert J Beynon
  • Scott D Sharrow
  • Victoria Lee
  • Jane L Hurst
  • Russell Corbett-Detig
  • Michael W Nachman
  • Ke Bi
  • R T Sorbi
  • Ching Fai Kwok
  • Kuang Chung Shih
  • A Spisni
  • Yan Jie Lin
  • Low Tone Ho
  • Yung Pei Hsu
  • Tzung Yan Lee
  • M J Rogers
  • R A Friesner
  • Stanley Neufeld
  • B J Berne
  • John Cobb
  • S R Kleeberger
  • E Lacazette
  • Edward W Kraegen
  • Donghai Wu
  • Weidong Zhu
  • Jialiang Zhang
  • Liangyou Rui
  • Yixue Li
  • Yu Wang
  • Lin Jiang
  • Karen S L Lam
  • Aimin Xu
  • Part Peterson
  • F Lohr
  • Kai Kisand
  • H Rüterjans
  • Martti Laan
  • Andres Merits
  • Hamish S Scott
  • L Franzoni
  • Alan Saghatelian
  • Koji Sato
  • Benjamin F Cravatt
  • Sachiko Haga
  • Francesco Nodari
  • Timothy E Holy
  • Kazushige Touhara
  • Kelly Flanagan
  • J Fleming
  • Jason R Cruz
  • Sharan Ramaswamy
  • Pere Puigserver
  • Rafael De Cabo
  • Nathan L Price
  • Kaitlyn Lewis
  • Kevin G Becker
  • David A Sinclair
  • Carles Lerin
  • David Le Couteur
  • Paul J Pistell
  • Joanne S Allard
  • Olivier Boss
  • Vinayakumar V Prabhu
  • Richard G Spencer
  • Reuben J Shaw
  • Hamish A Jamieson
  • Suresh Poosala
  • Edward G Lakatta
  • Kenneth W Fishbein
  • Dana Gwinn

Detail Information


  1. ncbi Terminology for prealbumin loci in the house mouse
    F H Wilcox
    J Hered 67:113. 1976
  2. ncbi Linkage analysis of the murine interferon alpha locus (Ifa) on chromosome 4
    E De Maeyer
    J Hered 78:143-6. 1987
    ..6 (+/- 3.6)--Ifa--7.9 (+/- 2.8)--m and from a second three-point cross Mup-1--1.7 (+/- 1.7)--b--3.5 (+/- 2.4)--Ifa. The combined results indicate that the gene order, from the centromere, is Mup-1--b--Ifa--m...
  3. ncbi Variation between mouse major urinary protein genes isolated from a single inbred line
    A J Clark
    Gene 18:221-30. 1982
    ..Homologies between different cloned sequences extend over as much as 15 kb. No clone contains parts of two MUP genes, and no homology has been detected between the 3' flanking region of one MUP gene and the 5' flanking region of another...
  4. ncbi Biosynthesis of the major urinary proteins in mouse liver: a biochemical genetic study
    F G Berger
    Biochem Genet 19:1261-73. 1981
    ..These findings are consistent with the notion that MUP expression is controlled by a variety of independently assorting genes...
  5. pmc Ligand binding to protein-binding pockets with wet and dry regions
    Lingle Wang
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 108:1326-30. 2011
  6. pmc Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines
    B A Taylor
    J Virol 23:106-9. 1977
    ..6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b...
  7. ncbi Messenger RNAs coding for mouse major urinary proteins are differentially induced by testosterone
    P M Clissold
    Biochem Genet 22:379-87. 1984
    ..We argue that some MUP structural genes are quite actively transcribed in females and that the transcription of others is dependent to different degrees upon induction by testosterone...
  8. ncbi The gene family for major urinary proteins: expression in several secretory tissues of the mouse
    P H Shaw
    Cell 32:755-61. 1983
    The major urinary proteins (MUPs) of the mouse are encoded by a multigene family located at the Mup a locus on chromosome 4...
  9. pmc Sequence structures of a mouse major urinary protein gene and pseudogene compared
    A J Clark
    EMBO J 4:3159-65. 1985
    ..The 12 acceptor splice sites of the two genes all contain the identical sequence ACAG at the exon boundary.(ABSTRACT TRUNCATED AT 250 WORDS)..
  10. pmc Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation in the liver
    N J Kuhn
    Nucleic Acids Res 12:6073-90. 1984
    ..Both sequences appear to be regulated by growth hormone and testosterone. Southern blot analysis of mouse genomic DNA indicates that there are multiple genes homologous to each sequence...
  11. pmc Two main groups of mouse major urinary protein genes, both largely located on chromosome 4
    J O Bishop
    EMBO J 1:615-20. 1982
    ..An analysis of mouse-Chinese hamster hybrid cell lines shows that most, if not all, Group 1 and Group 2 genes are located on mouse chromosome 4...
  12. pmc Nucleotide sequences of liver, lachrymal, and submaxillary gland mouse major urinary protein mRNAs: mosaic structure and construction of panels of gene-specific synthetic oligonucleotide probes
    K Shahan
    Mol Cell Biol 7:1938-46. 1987
    ..Shahan, M. Denaro, M. Gilmartin, Y. Shi, and E. Derman, Mol. Cell. Biol. 7:1947-1954, 1987), to characterize the expression of MUP genes I through V...
  13. pmc Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver
    K Shahan
    Mol Cell Biol 7:1947-54. 1987
    ..When a particular MUP gene is expressed in several tissues, transcripts of this gene initiate at the same site and are spliced and polyadenylated in the same manner...
  14. ncbi Sex- and strain-specific expression and vomeronasal activity of mouse ESP family peptides
    Hiroko Kimoto
    Department of Integrated Biosciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Curr Biol 17:1879-84. 2007
    ..The chemosensation of this nonvolatile peptide family by direct contact appears to be one of strategies for sociosexual communication in rodent species...
  15. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
    ..Our results substantiate the idea of MUP proteins as pheromone ligands that mediate male-male aggression through the accessory olfactory neural pathway...
  16. pmc Species specificity in major urinary proteins by parallel evolution
    Darren W Logan
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 3:e3280. 2008
    ..Our findings illustrate that increasing genomic complexity of the Mup gene family is not evolutionarily isolated, but is instead a recurring mechanism of generating coding diversity consistent with a species-specific function in mammals...
  17. pmc A 45-kb DNA domain with two divergently orientated genes is the unit of organisation of the murine major urinary protein genes
    A J Clark
    EMBO J 3:2055-64. 1984
    ..We also show that some MUP genes may be linked in a tail-to-tail fashion with 26-28 kb between the 3' ends of two genes. This suggests that the minimum distance between successive 45-kb units is approximately 7 kb...
  18. ncbi Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography
    Z Bocskei
    Department of Biochemistry and Molecular Biology, University of Leeds, UK
    Nature 360:186-8. 1992
    ..4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding...
  19. pmc Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a comparison with an active gene out with group 1 both suggest that gene conversion has occurred between MUP genes
    A J Clark
    EMBO J 4:3167-71. 1985
    ..We show here that mouse urine does indeed contain a glycosylated MUP protein with those properties, presumably the product of the gene that corresponds to pMUP15...
  20. pmc Molecular heterogeneity in the Major Urinary Proteins of the house mouse Mus musculus
    D H Robertson
    Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, U K
    Biochem J 316:265-72. 1996
    ..In the two strains there are at least 13 different MUPs, either observed or predicted, indicating the heterogeneity of expression of this group of proteins...
  21. ncbi The genetic mapping of a defective LPS response gene in C3H/HeJ mice
    J Watson
    J Immunol 120:422-4. 1978
    ..A value of 0.06 +/- 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci...
  22. pmc Rearrangement of genes located on homologous chromosomal segments in mouse and man: the location of genes for alpha- and beta-interferon, alpha-1 acid glycoprotein-1 and -2, and aminolevulinate dehydratase on mouse chromosome 4
    J H Nadeau
    Genetics 114:1239-55. 1986
    ..This result suggests that caution must be exercised when using M. spretus in linkage crosses...
  23. ncbi The response of recombinant inbred strains of mice to bacterial lipopolysaccharides
    J Watson
    J Immunol 118:2088-93. 1977
    ..The association of the expression of the Mup-1 alleles with LPS responsiveness in the BXH strains suggests that the defective LPS response gene in C3H/HeJ mice is located on chromosome 4...
  24. doi Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model
    Chin Chang Chen
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Biochem Biophys Res Commun 460:1063-8. 2015
    ..Cannabinoid receptor type 1 (CB1R) and major urinary protein 1 (MUP1) are thought to play pivotal roles in mitochondrial dysfunction, liver steatosis and insulin ..
  25. ncbi Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity
    S K Datta
    J Immunol 129:1539-44. 1982
  26. pmc p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
    N Watanabe
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo, Japan
    EMBO J 16:3044-56. 1997
    ..Overexpression of p140mDia in COS-7 cells induced homogeneous actin filament formation. These results suggest that Rho regulates actin polymerization by targeting profilin via p140mDia beneath the specific plasma membranes...
  27. ncbi A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres
    E Lacazette
    Laboratoire de Biochimie Médicale Prof B Dastugue, INSERM U384, Faculte de Medecine, 28 Place Henri Dunant, 63000 Clermont Ferrand, France
    Hum Mol Genet 9:289-301. 2000
    ..This is consistent with a positive selection pressure in vertebrate evolution in the intron-late hypothesis...
  28. ncbi Thermodynamic analysis of binding between mouse major urinary protein-I and the pheromone 2-sec-butyl-4,5-dihydrothiazole
    Scott D Sharrow
    Department of Chemistry and Institute for Pheromone Research, Indiana University, Bloomington 47405 0001, USA
    Biochemistry 42:6302-9. 2003
  29. pmc Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  30. pmc Tissue-specific expression of major urinary protein (MUP) genes in mice: characterization of MUP mRNAs by restriction mapping of cDNA and by in vitro translation
    K Shahan
    Mol Cell Biol 4:2259-65. 1984
    ..The relevance of these results to models of evolution of tissue-specific regulation in a multigene family is discussed...
  31. pmc Selection on Coding and Regulatory Variation Maintains Individuality in Major Urinary Protein Scent Marks in Wild Mice
    Michael J Sheehan
    Neurobiology and Behavior, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 12:e1005891. 2016
    ..Balancing selection on gene regulation allows for increased individuality via combinatorial diversity in a limited number of pheromones. ..
  32. ncbi Serum prealbumin in inbred strains of Mus musculus
    L Claxton
    Biochem Genet 11:97-102. 1974
  33. pmc Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping
    P Belgrader
    Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263
    Mol Cell Biol 14:6326-36. 1994
    ..This suggests that a 5' splice site may extend as far as 12 nucleotides into the upstream exon, which is, to our knowledge, the largest extension...
  34. pmc Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency
    M J Berry
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    J Clin Invest 92:1517-28. 1993
    ..We propose the symbol Dio1 to denote the mouse 5'DI gene. Conserved linkage between this segment of mouse chromosome 4 and human HSA1p predicts this location for human Dio1...
  35. pmc MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage
    K Mizuno
    Tokyo Metropolitan Institute for Neuroscience, Japan
    Mol Cell Biol 13:5513-23. 1993
    ..Finally, the MPTP delta locus was tightly linked to the brown (b) locus on mouse chromosome 4...
  36. ncbi CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
    C A Smith
    Immunex Research and Development Corporation, Seattle, Washington 98101
    Cell 73:1349-60. 1993
    ..The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively...
  37. ncbi Expression of a lipocalin in Pichia pastoris: secretion, purification and binding activity of a recombinant mouse major urinary protein
    E Ferrari
    Istituto di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Parma, Italy
    FEBS Lett 401:73-7. 1997
    ..This finding suggests that the protein, and in particular its hydrophobic binding pocket, is properly folded...
  38. ncbi Complete 1H, 15N and 13C assignment of a recombinant mouse major urinary protein
    F Abbate
    J Biomol NMR 15:187-8. 1999
  39. pmc Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice
    Xiaoyan Hui
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 284:14050-7. 2009
  40. doi Shox2 function couples neural, muscular and skeletal development in the proximal forelimb
    Lori Vickerman
    Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
    Dev Biol 350:323-36. 2011
    ..These data demonstrate that Shox2 is required for normal skeletal, neural and muscular development in the forelimb at a similar early developmental stage in each tissue...
  41. pmc Subfamily of submaxillary gland-specific Mup genes: chromosomal linkage and sequence comparison with liver-specific Mup genes
    Y Shi
    Public Health Research Institute of the City of New York, Inc, NY 10016
    Nucleic Acids Res 17:6191-203. 1989
    ..The comparison shows that the differentially expressed Mup genes are uniformly divergent in exons, introns and in their flanking sequences. The regions of homology extend at least 5 kb into the 5' flanking region of Mup genes...
  42. ncbi Ly-29: a locus closely linked to Mtv-20 on chromosome 4 codes for a new mouse lymphocyte surface alloantigen
    L J Gonez
    Immunogenetics 22:305-8. 1985
  43. pmc Evolutionary amplification of a pseudogene
    P Ghazal
    Proc Natl Acad Sci U S A 82:4182-5. 1985
    ..Taking into account the 3' flanking regions of the two genes, the overall size of each gene-pair is about 45 kilobases. The sequencing data supports our earlier suggestion that this 45 kilobase domain is the unit of Mup amplification...
  44. ncbi The rat gene map
    C Szpirer
    Curr Top Microbiol Immunol 137:33-8. 1988
  45. ncbi Localization of the gene for beta 1,4-galactosyltransferase to a position in the centromeric region of mouse chromosome 4
    N L Shaper
    Cell Structure and Function Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21250
    Cytogenet Cell Genet 54:172-4. 1990
    ..; Ggtb) was localized to the centromeric region of mouse Chromosome 4, between Mtv-14 and Mtv-17, using Southern blot analysis of an intersubspecies backcross...
  46. ncbi A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes
    J D Ceci
    Mammalian Genetics Laboratory, BRI Basic Research Program, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 5:699-709. 1989
    ..This linkage map will provide a framework for identifying homologous genes in mice and humans that may be involved in various disease processes...
  47. ncbi Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase
    A D Reith
    Ludwig Institute for Cancer Research, London, UK
    Mamm Genome 6:689. 1995
  48. ncbi Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia
    M Niwa-Kawakita
    Laboratory of Experimental Animal Science, Saitama Cancer Center Research Institute, Japan
    Genomics 29:755-9. 1995
    ..The chromosomal location was also confirmed by fluorescence in situ hybridization...
  49. ncbi Linkage analysis of the murine mos proto-oncogene on chromosome 4
    F Dandoy
    CNRS URA 1343, Institut Curie Biologie, Centre Universitaire, Orsay, France
    Genomics 4:546-51. 1989
    ..6 +/- 4.9 recombination units. The linkage data obtained in the present study place Mos in a region compatible with the physical map (D. W. Threadgill and J. E. Womack, 1988, Genomics 3: 82-86)...
  50. ncbi Intraspecific evolution of a gene family coding for urinary proteins
    R Al-Shawi
    Department of Genetics, University of Edinburgh, Scotland
    J Mol Evol 29:302-13. 1989
    ..The phylogenetic grouping correlates with grouping according to aspects of function. The genomes of the inbred strains BALB/c and C57BL contain different MUP gene arrays that we take to be samples from the wild population of arrays...
  51. ncbi Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice
    M Okumoto
    Department of Allied Biological Science, University of Osaka Prefecture, Sakai, Japan
    Cancer Res 50:3848-50. 1990
  52. ncbi Solution structure of a recombinant mouse major urinary protein
    C Lucke
    Institute of Biophysical Chemistry, J W Goethe University of Frankfurt, Germany
    Eur J Biochem 266:1210-8. 1999
    ..The shape of the beta-barrel resembles a calyx, lined inside by mostly hydrophobic residues that are instrumental for the binding and transport of small nonpolar ligand molecules...
  53. ncbi Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm)
    C Szpirer
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode St Genese, Belgium
    Genomics 6:679-84. 1990
  54. pmc Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets
    B K Lee
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Virol 64:4568-72. 1990
    ..Mtv-30 was genetically mapped to chromosome 12. Additionally, two previously identified Mtv loci, Mtv-14 and Mtv-23, were genetically mapped to chromosome 4 and chromosome 6, respectively...
  55. ncbi A quantitative genetic analysis of slow-wave sleep and rapid-eye movement sleep in CXB recombinant inbred mice
    L A Toth
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Behav Genet 29:329-37. 1999
    ..Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels...
  56. ncbi Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4
    S R Kleeberger
    Department of Environmental Health Sciences, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 22:620-7. 2000
    ..Together, results indicate that a QTL on mouse chromosome 4 explains a significant portion of the genetic variance in O(3)-induced hyperpermeability, and support a role for Tlr4 as a strong candidate susceptibility gene...
  57. pmc Structural basis of pheromone binding to mouse major urinary protein (MUP-I)
    D E Timm
    Department of Biochemistry, Indiana University, Indianapolis, Indiana 46202, USA
    Protein Sci 10:997-1004. 2001
  58. ncbi Genetic regulation of lipopolysaccharide responses in NZB mice
    E A Bearer
    Division of Rheumatology Allergy and Clinical Immunology, University of California, Davis
    Exp Clin Immunogenet 6:193-203. 1989
    ..Interestingly, the hypergammaglobulinemia and anti-DNA antibody levels in 6-month-old Lpsd mice did not differ from those of NZB mice despite the absence of LPS-responsive CFU-B...
  59. pmc Silent and expressed sister Mup genes are located within distinct chromatin domains: analysis by pulsed-field gel electrophoresis and polymerase chain reaction-supplemented DNase I digestion
    M Rodriguez
    Public Health Research Institute of the City of New York, Inc, New York 10016
    Mol Cell Biol 12:1188-93. 1992
    ..5b gene. This finding suggests that the inactivity of the Mup-1.5b gene is brought about by long range-acting mechanisms that establish a chromatin structure in the vicinity of this gene incompatible with transcription...
  60. pmc Modulation of Aire regulates the expression of tissue-restricted antigens
    Vivian Kont
    Molecular Pathology, Biomedicum, Tartu University, Ravila 19, 50411 Tartu, Estonia
    Mol Immunol 45:25-33. 2008
    ..The data underline a direct role for Aire in TRA expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity...
  61. ncbi Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome
    R J Cornall
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK
    Mamm Genome 3:620-4. 1992
    ..Eight (62%) of the 13 repeats that have been mapped lie on Chromosomes (Chr) 4 and 6. This approach is an effective way of generating informative markers on specific chromosomes...
  62. ncbi Identification and genetic monitoring of mouse inbred strains using biochemical polymorphisms
    A Groen
    Lab Anim 11:209-14. 1977
    ..These findings emphasize the possibility and the necessity of monitoring the genetic purity of inbred strains of mice. A routine monitoring scheme using body protein-polymorphisms is proposed...
  63. pmc Identification of MUP1 as a regulator for glucose and lipid metabolism in mice
    Yingjiang Zhou
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    J Biol Chem 284:11152-9. 2009
    Major urinary protein (MUP) 1 is a lipocalin family member abundantly secreted into the circulation by the liver. MUP1 binds to lipophilic pheromones and is excreted in urine...
  64. ncbi Regulation by androgen of mRNA level for the major urinary protein complex in mouse liver
    S Osawa
    Biochem Biophys Res Commun 77:628-33. 1977
  65. ncbi A second gene affecting the sialylation of lysosomal alpha-mannosidase in mouse liver
    M Dizik
    Biochem Genet 16:247-60. 1978
    ..In contrast, at the Map-1 locus, the more negatively charged phenotype is dominant. The electrophoretic pattern of development of the liver enzyme from SM/JCv mice is described...
  66. ncbi Genetically determined electrophoretic variants of the major urinary protein (Mup) complex in mouse urine
    A Groen
    Anim Blood Groups Biochem Genet 10:107-14. 1979
    ..The Mup phenotypes described, can be useful for the detection of certain strain contaminations, especially if F1 hybrid Mup phenotypes are distinguishable...
  67. pmc Genetic control of endotoxic responses in mice
    J Watson
    J Exp Med 147:39-49. 1978
    ..These linkage studies provide a means for analyzing the genetic control of many of the diverse reactions of the endotoxic response to LPS...
  68. ncbi A new allele at the Mup-1 locus controlling an electrophoretic variant of major urinary proteins in mice
    H Nikaido
    J Hered 75:59-61. 1984
    ..Thus, it is concluded that the locus is identical to Mup-1 and it is proposed that Mup-1c be designated as the allele that determines a third phenotypic form of MUPs in MOA mice...
  69. ncbi Variations among sublines of inbred AKR mice
    R T Acton
    Nat New Biol 245:8-10. 1973
  70. pmc Variation in the major urinary protein multigene family in wild-derived mice
    B M Sampsell
    Genetics 109:549-68. 1985
    ..Analysis of urinary proteins from hybrids between C57BL/6 and M. spretus suggested that low MUP expression in M. spretus females was due to cis-acting genetic elements...
  71. ncbi Location of the Mup-a locus on mouse linkage group 8
    J S Finlayson
    Genet Res 14:329-31. 1969
  72. ncbi Linkage of one component of the major urinary protein complex of mice to the brown coat color locus
    D M Hudson
    Genet Res 10:195-8. 1967
  73. ncbi A new lymphocyte cell surface antigen, Ly-22.2, controlled by a locus on chromosome 4 and a second unlinked locus
    D Meruelo
    J Immunol 130:946-50. 1983
    ..Strain distribution studies show Ly-22.2 is present in all strains examined except B10-derived congenic strains. It is of interest that C57BL/6 and C57BL/10 mice differ in the expression of this antigen...
  74. ncbi Conserved linkage of soluble aconitase and galactose-1-phosphate uridyl transferase in mouse and man: assignment of these genes to mouse chromosome 4
    J H Nadeau
    Cytogenet Cell Genet 34:271-81. 1982
    ..The conserved linkage of Aco-1 and Galt in mouse and man probably represents an ancient linkage not yet disrupted by chromosomal rearrangement, rather than a linkage preserved by natural selection...
  75. ncbi Map position of dysgenetic lens (dyl) locus on chromosome 4 in the mouse
    S Sanyal
    Genet Res 48:199-200. 1986
  76. pmc Structure of mouse major urinary protein genes: different splicing configurations in the 3'-non-coding region
    A J Clark
    EMBO J 3:1045-52. 1984
    ..Silent sites have diverged four times more rapidly than replacement sites, showing that there has been selection against change in the protein sequence...
  77. ncbi Early development in mice. IV. Age at disappearance of the rooting response: genetic analysis in newborn mice
    P L Roubertoux
    Behav Genet 17:453-64. 1987
  78. ncbi Components of major urinary proteins (MUP's) in the mouse. Sex, strain, and subspecies differences
    J Hayakawa
    J Hered 74:453-6. 1983
    ..In addition, the present methods revealed that both liver and serum contained MUP's consisting of components similar to those found in the urine from the same sex and strain...
  79. ncbi Major urinary protein and immunoglobulin allotypes of recombinant inbred mouse strains
    M Potter
    Genet Res 22:325-8. 1973
  80. pmc Two loci affecting B cell responses to B cell maturation factors
    C L Sidman
    J Exp Med 163:116-28. 1986
    ..The effect of Bmfr-2 on B cell responsiveness may be related to levels of the steroid sex hormones. DBA/2Ha mice offer a tool for studying the genetic and hormonal regulation of the immune system...
  81. pmc Mapping the structural genes coding for the major urinary proteins in the mouse: combined use of recombinant inbred strains and somatic cell hybrids
    K L Bennett
    Proc Natl Acad Sci U S A 79:1220-4. 1982
    ..The combination of these mapping techniques should be applicable to many cloned DNA sequences...
  82. ncbi Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A
    R Michalides
    Virology 142:278-90. 1985
    ..R. Callahan, D. Gallahan, and Ch. Kozak (1984), J. Virol. 49, 1005-1008). GR and GR.Mtv-2 furthermore contain two incomplete MMTV proviral elements, one of which is also present in STS/A...
  83. ncbi Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene
    A D O'Brien
    J Immunol 124:20-4. 1980
  84. ncbi A genetic linkage map of rat chromosome 5 reveals extensive linkage conservation with mouse chromosome 4
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Fukaya, Japan
    Mamm Genome 5:222-4. 1994
    Linkages among three biochemical loci (Aco1, Ahd2, and Mup1) and four microsatellite loci (A8, Glut1, Jun, and Pnd) were determined to construct a linkage map of rat Chromosome (Chr) 5...
  85. pmc Acquisition of antigens characteristic of adult pericentral hepatocytes by differentiating fetal hepatoblasts in vitro
    A L Bennett
    Rockefeller University, New York 10021
    J Cell Biol 105:1073-85. 1987
    ..These findings suggest that a sequence of gene controls characterizes expression of specific genes in developing liver, and that differentiating fetal hepatoblasts are capable of undergoing similar patterns of gene activity in culture...
  86. ncbi Structure and chromosomal locus of the mouse gene encoding a cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3
    T Sakagami
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 203:594-601. 1994
    ..These results suggest that the Hes-3 and Hes-5 genes may be clustered on chromosome 4 while the Hes-1 gene is not...
  87. ncbi Linkage analysis of the whirler deafness gene on mouse chromosome 4
    J Fleming
    MRC Institute of Hearing Research, Nottingham, United Kingdom
    Genomics 21:42-8. 1994
    ..We therefore predict that a human homologue of the wi gene, involved in autosomal recessive deafness, lies in this region of conserved homology on 9q32-q34...
  88. ncbi Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein
    Richard J Bingham
    Astbury Centre for Structural Molecular Biology, School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT Leeds, UK
    J Am Chem Soc 126:1675-81. 2004
    ..The principal driving force governing ligand affinity and specificity can be attributed to solvent-driven enthalpic effects from desolvation of the protein binding pocket...
  89. ncbi Genetic mapping of the whirler mutation
    M J Rogers
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Mamm Genome 10:513-9. 1999
    ..In the intraspecific backcross, wi was found to be non-recombinant with Orm1 and D4Mit244, 0.3 cM distal of Mup1, and 0.6 cM proximal of Tnc...
  90. pmc Genetic regulation of hypergammaglobulinaemia and the correlation to autoimmune traits in (NZB X NZW) F1 hybrid
    S Hirose
    Clin Exp Immunol 58:694-702. 1984
  91. pmc Linkage analysis of the murine interferon-alpha locus on chromosome 4
    F Dandoy
    J Exp Med 160:294-302. 1984
    ..It can therefore be concluded that the IFN-alpha gene cluster is situated on chromosome 4 near the H-15 locus, between loci Mup-1 and b...
  92. ncbi A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse
    T H Roderick
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 42:393-6. 1997
    ..A human homolog would be expected to be located on human chromosomes 1p or 8q...
  93. pmc Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor
    J Caubín
    Departamento de Investigacion, Pharmacia Antibióticos Farma S A, Madrid, Spain
    Nucleic Acids Res 22:4132-8. 1994
    ..This method, extensive to other ligand-modulated transcription factors, might be useful to all transcription factors with slight modifications...
  94. ncbi Novel mouse microsatellites: primer sequences and chromosomal location
    T Suda
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    DNA Res 1:169-74. 1994
    ..The microsatellites were distributed to most chromosomes except for chromosomes 16 and 19. These novel markers with defined locations are useful in linkage and genome mapping studies...

Research Grants6

  1. Evolutionary studies of mouse seminal fluid protein genes
    ROBERT KARN; Fiscal Year: 2008
    ..Disease research may benefit from studies of selection, since positive selection is often associated with human disease genes. [unreadable] [unreadable] [unreadable]..
  2. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  5. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..