Mst1r

Summary

Gene Symbol: Mst1r
Description: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Alias: CD136, CDw136, Fv-2, Fv2, PTK8, Ron, STK, macrophage-stimulating protein receptor, MSP receptor, friend virus susceptibility 2, p185-Ron, receptor protein tyrosine kinase, c-met-related, stem cell-derived tyrosine kinase
Species: mouse

Top Publications

  1. ncbi Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer
    Belinda E Peace
    Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Cancer Res 65:1285-93. 2005
  2. ncbi Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure
    Mike A Leonis
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati, OH 45229, USA
    Hepatology 36:1053-60. 2002
  3. ncbi Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo
    Yi Qing Chen
    Division of Pulmonary Sciences and Critical Care, Department of Medicine, University of Colorado School of Medicine, CU Cancer Center, and Denver Health Medical Center, Denver, Colorado, CO 80204, USA
    Oncogene 21:6382-6. 2002
  4. ncbi Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
    Glendon M Zinser
    Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267, USA
    Cancer Res 66:11967-74. 2006
  5. pmc Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses
    S E Waltz
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 108:567-76. 2001
  6. ncbi The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
    Ryan M Thomas
    Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cancer Res 67:6075-82. 2007
  7. ncbi The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity
    Caleph B Wilson
    Graduate Program in Pathobiology, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 181:2303-10. 2008
  8. pmc Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production
    Nikolaos M Nikolaidis
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Shock 33:197-204. 2010
  9. pmc The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis
    Sara E Meyer
    Department of Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267 0521, USA
    Dev Biol 333:173-85. 2009
  10. pmc Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers
    Jocelyn Logan-Collins
    Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Ohio, USA
    Cancer Res 70:1130-40. 2010

Research Grants

  1. HEPATOCYTE GROWTH FACTOR LIKE PROTEIN RECEPTOR
    Susan Waltz; Fiscal Year: 2003
  2. Research in Alimentary Tract Surgery
    Susan Waltz; Fiscal Year: 2007
  3. The Ron Receptor in Mammary Gland Biology
    Susan Waltz; Fiscal Year: 2008
  4. Hepatocyte Growth Factor-like Protein Receptor
    Susan Waltz; Fiscal Year: 2009
  5. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009

Scientific Experts

  • Susan Waltz
  • Carol R Gardner
  • DEBRA LYNN LASKIN
  • William D Stuart
  • Devikala Gurusamy
  • Jerilyn K Gray
  • Glendon M Zinser
  • Rishikesh M Kulkarni
  • Belinda E Peace
  • P K Wagh
  • Pamela H Correll
  • Shuang Ni
  • Kenya Toney-Earley
  • Daniel R Sharda
  • Sandra J F Degen
  • Manujendra Ray
  • Pamela A Hankey
  • Mike A Leonis
  • Sara E Meyer
  • Peterson Pathrose
  • Abby L Johnson
  • Robert F Paulson
  • Purnima K Wagh
  • Margaret H Collins
  • Shailaja Hegde
  • Xin Wei
  • Caleph B Wilson
  • Ryan M Thomas
  • Karla Ann Hess
  • Yong Qing Zhou
  • L M Privette Vinnedge
  • Alex B Lentsch
  • Andrew M Paluch
  • Masako Akiyama
  • Henok Eyob
  • Daniel R Prows
  • Michaela Kaldenbach
  • Aaron M Marshall
  • Ali Mallakin
  • Edward L Chan
  • M N Thobe
  • J K Gray
  • Shan Yu
  • Naveen Kaushal
  • K Sandeep Prabhu
  • Nikolaos M Nikolaidis
  • Jocelyn Logan-Collins
  • Susan A McDowell
  • Shihan He
  • Daigo Umehara
  • Ming hai Wang
  • Kazuo Nishigaki
  • Louis W Kutcher
  • Sandra Ruscetti
  • Charlotte Hanson
  • Andrew M Lowy
  • Tanya M Jelacic
  • Yi Qing Chen
  • Qingping Liu
  • Ning Li
  • Cynthia C Wetzel
  • Fudi Wang
  • Kenya Toney
  • Sarah A Kader
  • Jie Xu
  • Elles M J Boon
  • Serena Germano
  • Shigeki Tsutsui
  • Xiang Ming Xu
  • George D Leikauf
  • Michael A Lutz
  • A Bernstein
  • Alison Forgie
  • J Serrano-López
  • N A Pease
  • S I Wells
  • A K Adams
  • M A Nashu
  • Nicholas E Brown
  • R F Paulson
  • J A Cancelas
  • N M Benight
  • Dana A Smith
  • Sasha J Ruiz-Torres
  • James H Fisher
  • Edward Melkun
  • Amy C Morrison
  • Raffaella De Maria
  • Helmut Glantschnig
  • Ikuo Morita

Detail Information

Publications92

  1. ncbi Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer
    Belinda E Peace
    Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Cancer Res 65:1285-93. 2005
    The tyrosine kinase receptor Ron has been implicated in several types of cancer, including overexpression in human breast cancer...
  2. ncbi Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure
    Mike A Leonis
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati, OH 45229, USA
    Hepatology 36:1053-60. 2002
    The targeted deletion of the cytoplasmic domain of the Ron receptor tyrosine kinase (TK) in mice leads to exaggerated responses to injury in several murine models of inflammation as well as increased lethality in response to endotoxin (..
  3. ncbi Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo
    Yi Qing Chen
    Division of Pulmonary Sciences and Critical Care, Department of Medicine, University of Colorado School of Medicine, CU Cancer Center, and Denver Health Medical Center, Denver, Colorado, CO 80204, USA
    Oncogene 21:6382-6. 2002
    b>RON, a member of the MET proto-oncogene family, has been implicated in the progression of certain epithelial cancers. The purpose of this study was to determine the oncogenic potential of RON in vivo in lung epithelial cells...
  4. ncbi Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
    Glendon M Zinser
    Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267, USA
    Cancer Res 66:11967-74. 2006
    ..b>Ron, a member of the Met RTK proto-oncogene family, is overexpressed or constitutively active in 50% of human breast ..
  5. pmc Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses
    S E Waltz
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 108:567-76. 2001
    b>Ron receptor activation induces numerous cellular responses in vitro, including proliferation, dissociation, and migration...
  6. ncbi The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
    Ryan M Thomas
    Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cancer Res 67:6075-82. 2007
    ..The recepteur d'origine nantais (RON) receptor tyrosine kinase is overexpressed and/or constitutively active in several epithelial cancers, but its role ..
  7. ncbi The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity
    Caleph B Wilson
    Graduate Program in Pathobiology, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 181:2303-10. 2008
    ..We have shown previously that the RON receptor tyrosine kinases (murine Stk), expressed on tissue-resident macrophages, inhibit classical macrophage ..
  8. pmc Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production
    Nikolaos M Nikolaidis
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Shock 33:197-204. 2010
    The Ron receptor tyrosine kinase (TK) plays a regulatory role in the inflammatory response to acute lung injury induced by intranasal administration of bacterial LPS...
  9. pmc The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis
    Sara E Meyer
    Department of Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267 0521, USA
    Dev Biol 333:173-85. 2009
    The Ron receptor tyrosine kinase is expressed in normal breast tissue and is overexpressed in approximately 50% of human breast cancers...
  10. pmc Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers
    Jocelyn Logan-Collins
    Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Ohio, USA
    Cancer Res 70:1130-40. 2010
    The RON receptor tyrosine kinase is overexpressed in premalignant pancreatic intraepithelial neoplasia (PanIN) and in the majority of pancreatic cancers...
  11. pmc Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury
    Ali Mallakin
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
    Am J Respir Cell Mol Biol 34:15-27. 2006
    Previous studies have shown that mice deficient in the tyrosine kinase domain (TK-/-) of the receptor Mst1r have an increased susceptibility to nickel (Ni)-induced acute lung injury (ALI)...
  12. ncbi Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis
    Edward L Chan
    Department of Pediatrics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0558, USA
    Oncogene 24:479-88. 2005
    Recent studies demonstrate that the receptor tyrosine kinase (TK) Ron is tumorigenic when overexpressed and plays a role in regulating skin homeostasis. We hypothesized that Ron signaling promotes skin carcinogenesis...
  13. pmc Vitamin D3-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity
    Abby L Johnson
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
    Oncotarget 6:16304-20. 2015
    The Ron receptor is upregulated in human breast cancers and correlates with enhanced metastasis and reduced patient survival...
  14. pmc Loss of Ron receptor signaling leads to reduced obesity, diabetic phenotypes and hepatic steatosis in response to high-fat diet in mice
    William D Stuart
    Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio and
    Am J Physiol Endocrinol Metab 308:E562-72. 2015
    The Ron receptor tyrosine kinase is a heterodimeric, membrane-spanning glycoprotein that participates in divergent processes, including proliferation, motility, and modulation of inflammatory responses...
  15. pmc Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis
    Devikala Gurusamy
    Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Mech Dev 133:11-22. 2014
    The Ron receptor tyrosine kinase regulates multiple cellular processes and is important during mammary gland development and tumor progression...
  16. ncbi The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury
    Susan A McDowell
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
    Am J Respir Cell Mol Biol 26:99-104. 2002
    ..Macrophage activation is mediated, in part, via the receptor tyrosine kinase Ron. To address the role of Ron in ALI, the response of mice deficient in the cytoplasmic domain of Ron (Ron tk-/-) ..
  17. pmc The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers
    L M Privette Vinnedge
    Division of Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Oncogene 34:2325-36. 2015
    ..Here, we report that two commonly overexpressed breast cancer oncogenes, Ron (Recepteur d'Origine Nantaise) and DEK, cooperate to promote advanced disease through multipronged effects on β-..
  18. pmc Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia
    Rishikesh M Kulkarni
    Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45267 0521, USA
    Hepatobiliary Pancreat Dis Int 13:281-92. 2014
    b>Ron receptor tyrosine kinase signaling in macrophages, including Kupffer cells and alveolar macrophages, suppresses endotoxin-induced proinflammatory cytokine/chemokine production...
  19. pmc Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis
    Masako Akiyama
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Nutrients 5:3151-62. 2013
    ..Quantitative PCR analysis confirmed that DC-STAMP, an essential gene for the cell fusion process in osteoclastogenesis, and other osteoclast-related genes, such as Siglec-15, Tspan7 and Mst1r, were inhibited by DHA.
  20. pmc Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity
    Henok Eyob
    Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
    Cancer Discov 3:751-60. 2013
    ..We report that macrophage-stimulating protein and its receptor, Ron, are key mediators in conversion of micrometastases to bona fide metastatic lesions through immune suppression...
  21. pmc Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction
    C A Kozak
    J Virol 55:281-5. 1985
    ..Only M. spretus was resistant to virus-induced splenomegaly and did not restrict replication of Friend virus helper murine leukemia virus. Genetic studies confirmed that this mouse carries the resistance allele at Fv-2...
  22. ncbi Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice
    F Lilly
    J Natl Cancer Inst 45:163-9. 1970
  23. pmc Myeloid-specific expression of Ron receptor kinase promotes prostate tumor growth
    Devikala Gurusamy
    Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cancer Res 73:1752-63. 2013
    Ron receptor kinase (MST1R) is important in promoting epithelial tumorigenesis, but the potential contributions of its specific expression in stromal cells have not been examined...
  24. pmc Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure
    Rishikesh M Kulkarni
    Departments of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267 0521, USA
    Hepatobiliary Pancreat Dis Int 11:383-92. 2012
    Prior experimentation has shown that loss of the tyrosine kinase (TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharide-induced acute liver failure (ALF) in D-galactosamine (GalN)-..
  25. pmc Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
    Shailaja Hegde
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, 16802, USA
    Blood 118:6909-19. 2011
    ..Given the potency of ω-3 polyunsaturated fatty acid-derived CyPGs and the well-known refractoriness of LSCs to currently used clinical agents, Δ(12)-PGJ(3) may represent a new chemotherapeutic for leukemia that targets LSCs...
  26. pmc Ron receptor overexpression in the murine prostate induces prostate intraepithelial neoplasia
    Jerilyn K Gray
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, United States
    Cancer Lett 314:92-101. 2012
    Previous studies have shown that the Ron receptor is overexpressed in prostate cancer and Ron expression increases with disease severity in humans and the mouse TRAMP model...
  27. pmc Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice
    Aaron M Marshall
    Department of Cancer and Cell Biology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0521, USA
    Mol Cancer 11:2. 2012
    ..The Ron receptor is a tyrosine kinase receptor that has been implicated in the progression of breast cancer and evasion of ..
  28. doi Hepatocyte growth factor/c-Met signalling is important for the selection of transplanted hepatocytes
    Michaela Kaldenbach
    Department of Medicine III, RWTH Aachen University, Aachen, Germany
    Gut 61:1209-18. 2012
    ..This study investigated the cursiv relevance of hepatocyte growth factor (HGF)/c-Met signalling for hepatocyte repopulation after transplantion...
  29. pmc Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis
    Purnima K Wagh
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Endocrinology 153:2735-46. 2012
    The Ron receptor tyrosine kinase (macrophage stimulating 1 receptor) is overexpressed in approximately 50% of human breast cancers...
  30. pmc Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase
    Carol R Gardner
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 262:139-48. 2012
    Stem cell-derived tyrosine kinase (STK) is a transmembrane receptor reported to play a role in macrophage switching from a classically activated/proinflammatory phenotype to an alternatively activated/wound repair phenotype...
  31. ncbi Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity
    Xin Wei
    Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:40241-51. 2005
    ..We find that expression of mouse RON, but not human RON, results in constitutive receptor autophosphorylation, ligand-independent activation of the ..
  32. ncbi Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling
    Serena Germano
    Department DISCAFF and DFB Center, University of Piemonte Orientale A Avogadro, Novara 28100, Italy
    J Biol Chem 281:21710-9. 2006
    b>Ron, the tyrosine kinase receptor for macrophage-stimulating protein is responsible for proliferation and migration of cells from different tissues...
  33. ncbi Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase
    Xin Wei
    Graduate Program in Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 3500, USA
    J Biol Chem 280:35098-107. 2005
    ..We have shown that the murine Ron (mRon) receptor tyrosine kinase exhibits constitutive activation of the MAP kinase pathway that is independent of ..
  34. ncbi RON-regulated innate immunity is protective in an animal model of multiple sclerosis
    Shigeki Tsutsui
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 57:883-95. 2005
    The tyrosine kinase receptor RON and its ligand, macrophage stimulating protein (MSP), exert inhibitory effects on systemic innate immunity, but their CNS expression and impact on human neuroinflammatory diseases are unknown were RON and ..
  35. ncbi The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulation
    Karla Ann Hess
    Division of Developmental Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Fertil Steril 80:747-54. 2003
    To determine the reproductive effects in mice of the deletion of the tyrosine kinase domain of the Ron receptor.
  36. pmc Inheritance of Susceptibility to Friend Mouse Leukemia Virus: VI. Reciprocal Alteration of Innate Resistance or Susceptibility by Bone Marrow Transplantation Between Congenic Strains
    T Odaka
    Institute of Medical Science, Takanawa, Tokyo, Japan
    J Virol 4:837-43. 1969
    ..It is concluded that the locus Fv is expressed on hemopoietic cells, and cells derived from bone marrow play a predominant role in the development of splenomegaly by Friend leukemia virus...
  37. ncbi Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met
    Elles M J Boon
    Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cancer Sci 97:710-5. 2006
    ..Our findings thus reveal important interspecies differences in the regulation of Met expression during intestinal tumorigenesis...
  38. ncbi Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury
    Cynthia C Wetzel
    Department of Pediatrics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 292:G253-61. 2007
    Abrogation of Ron receptor tyrosine kinase function results in defects in macrophage activation and dysregulated acute inflammatory responses in vivo...
  39. pmc The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation
    Alex B Lentsch
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0558, USA
    Shock 27:274-80. 2007
    Emerging information implies that the Ron receptor tyrosine kinase may play a role in the inflammatory response. However, the manner in which this receptor contributes to the response is not well understood...
  40. pmc A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection
    Shuang Ni
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802 3500, USA
    Mol Cell Biol 27:3708-15. 2007
    ..expansion of infected cells, which is driven by the activation of a naturally occurring truncated form of the Stk receptor tyrosine kinase (Sf-Stk)...
  41. ncbi Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase
    Ning Li
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1074, USA
    J Biol Chem 282:16764-75. 2007
    ..These results indicate that the ubiquitin ligase activity of Cbl is critical for clathrin-dependent cMet internalization and suggest a role for Grb2 as an intermediary linking Cbl ubiquitin ligase activity to this process...
  42. ncbi Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Physiol Genomics 30:271-81. 2007
    ..QTL results confirmed that both parental strains contribute dominant resistance alleles to their offspring to determine individual HALI susceptibility...
  43. pmc The tyrosine kinase sf-Stk and its downstream signals are required for maintenance of friend spleen focus-forming virus-induced fibroblast transformation
    Tanya M Jelacic
    Laboratory of Cancer Prevention, Building 469, Room 205, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 82:419-27. 2008
    ..SFFV gp55, forms a complex with the erythropoietin receptor (EpoR) and a short form of the receptor tyrosine kinase Stk (sf-Stk), activating both and inducing Epo-independent proliferation...
  44. pmc Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk
    Shihan He
    Pathobiology Graduate Program, The Pennsylvania State University, University Park, Pennsylvania 16802 3500, USA
    J Virol 84:2223-35. 2010
    ..we demonstrate that a constitutively active form of Sf-Stk (Sf-StkM330T), as well as its human counterpart, Sf-Ron, promotes Epo-independent colony formation in the absence of gp55 and that this response is also dependent on the ..
  45. pmc Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice
    Sara E Meyer
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, OH 45267, USA
    Cancer Lett 296:186-93. 2010
    ..The Ron receptor tyrosine kinase is overexpressed in a large fraction of human breast cancers...
  46. pmc Role of phosphatidylinositol 3-kinase in friend spleen focus-forming virus-induced erythroid disease
    Daigo Umehara
    Laboratory of Molecular Immunology and Infectious Disease, Department of Veterinary Medicine, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Virol 84:7675-82. 2010
    ..of the viral envelope protein with the erythropoietin receptor and a short form of the receptor tyrosine kinase Stk (sf-Stk), leading to constitutive activation of several signal transduction pathways...
  47. pmc Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein
    Manujendra Ray
    Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 185:7309-16. 2010
    The RON receptor tyrosine kinase regulates the balance between classical (M1) and alternative (M2) macrophage activation...
  48. pmc β-Catenin is required for Ron receptor-induced mammary tumorigenesis
    P K Wagh
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Oncogene 30:3694-704. 2011
    Our previous studies demonstrated that selective overexpression of the Ron receptor tyrosine kinase in the murine mammary epithelium leads to mammary tumor formation...
  49. pmc The Ron receptor promotes prostate tumor growth in the TRAMP mouse model
    M N Thobe
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, OH, USA
    Oncogene 30:4990-8. 2011
    The Ron receptor tyrosine kinase (TK) is overexpressed in many cancers, including prostate cancer...
  50. pmc Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase
    Daniel R Sharda
    Graduate Program in Pathobiology, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 187:2181-92. 2011
    ..In this study, we demonstrate that the Ron receptor tyrosine kinase tips the balance of macrophage activation by attenuating the M1 phenotype while promoting ..
  51. pmc Linkage of the Fv-2 gene to a newly reinserted ecotropic retrovirus in Fv-2 congenic mice
    M Mowat
    J Virol 47:471-7. 1983
    ....
  52. pmc Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning
    G Celli
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 17:1642-55. 1998
    ....
  53. ncbi Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase
    Xiang Ming Xu
    Laboratory of Cheung Kong Scholars Program for Biomedical Sciences at Institute of Infectious Diseases and Division of Neurosurgery, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, People s Republic of China
    J Biol Chem 280:25087-94. 2005
    ..kinases regulate cytoplasmic beta-catenin accumulation, the effect of an oncogenic receptor originated from Nantes (RON) variant on beta-catenin accumulation and the role of beta-catenin in RON-mediated tumorigenic activities were ..
  54. pmc Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility
    O Sakamoto
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    J Clin Invest 99:701-9. 1997
    ..Its receptor, RON tyrosine kinase, is a new member of the HGF receptor family...
  55. ncbi Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development
    B Quantin
    INSERM U 211, Institut de Biologie CHR, Nantes, France
    Dev Dyn 204:383-90. 1995
    The human ron gene codes for a transmembrane protein tyrosine kinase which is a receptor for the macrophage stimulating protein...
  56. ncbi The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues
    G Gaudino
    Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
    Oncogene 11:2627-37. 1995
    We previously showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages...
  57. ncbi A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development
    M Gibbs
    Department of Genetics, University of Leicester, England
    Genomics 17:121-8. 1993
    ....
  58. ncbi Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9
    J P Jenuth
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada
    Genome 37:399-404. 1994
    ..A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5.5 and a 99% confidence interval of 3.9-33.9 cM...
  59. ncbi Fv-2 locus controls the proportion of erythropoietic progenitor cells (BFU-E) synthesizing DNA in normal mice
    S Suzuki
    Cell 19:225-36. 1980
    ..The gene that controls susceptibility or resistance to a murine erythroleukemia virus appears also to be a regulatory gene that controls the proliferative behaviour of normal cells at a specific stage of erythropoietic differentiation...
  60. pmc Mapping of aminoacylase-1 and beta-galactosidase-A to homologous regions of human chromosome 3 and mouse chromosome 9 suggests location of additional genes
    S L Naylor
    Am J Hum Genet 34:235-44. 1982
    ..Since the mouse transferrin gene (Trf) is closely linked to the aminoacylase and beta-galactosidase loci, we predict that the human transferrin (TF) gene is on chromosome 3...
  61. ncbi Fre2, a proviral integration site of Friend murine leukemia virus that is closely linked to Fv2
    R W Friedrich
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    Leukemia 11:619-23. 1997
    ..9 and 3.7 kb have been found near the breakpoint. Fre2 is closely linked to Fv2, a locus on mouse chromosome 9 involved in erythropoiesis...
  62. ncbi Chromosomal assignment of two murine genes controlling susceptibility to spleen focus formation by Rauscher leukemia virus
    E Heller
    Exp Hematol 12:645-9. 1984
    ..We suggest this gene be called Rv-3...
  63. pmc Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice
    N A Jenkins
    J Virol 42:379-88. 1982
    ....
  64. ncbi Cellular site and mode of Fv-2 gene action
    R R Behringer
    Cell 40:441-7. 1985
    ..Thus, with regard to this particular Fv-2 phenotype (susceptibility to FV-P-induced cellular hyperplasia), Fv-2 manifests itself specifically in the erythroid lineage, either in mature (d3) BFU-E or CFU-E...
  65. pmc Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human
    C Blatt
    Weizmann Institute, Rehovoth, Israel
    Proc Natl Acad Sci U S A 85:7642-6. 1988
    ..These mapping assignments will be useful in defining the extent of the G alpha gene family and may help in attempts to correlate specific genetic diseases with genes corresponding to G proteins...
  66. pmc Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene
    M E Hoatlin
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098
    Proc Natl Acad Sci U S A 87:9985-9. 1990
    ..These results have important implications for understanding signal transduction by EpoR and the role of host genetic variation in controlling susceptibility to an oncogenic protein...
  67. ncbi Genetic resistance to Friend leukemia virus in mice: masking of Fv-2 phenotype by an epistatic gene, Fv-4
    T Odaka
    Jpn J Exp Med 47:515-21. 1977
    ..It will be concluded that in G mice Fv-4r gene suppresses the virus replication, and hence masks the expression of Fv-2s gene. Data of F2 generation support this conclusion...
  68. pmc Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus
    R Risser
    J Exp Med 149:1152-67. 1979
    ..The similarity of FE antigen to Abelson antigen may provide insight into the pathogenic properties of defective transforming MuLV...
  69. ncbi Genetic control of antinuclear antibodies in mice infected with Rauscher leukemia virus
    B Varet
    Cancer Res 37:1115-8. 1977
    ..It can be concluded that C-type viruses play an active role in antinuclear antibody induction...
  70. ncbi Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation
    Helmut Glantschnig
    Department of Bone Biology and Osteoporosis, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 277:42987-96. 2002
    ..Further activation of MST1 by caspase cleavage is best promoted by caspase-3, although this appears to be unnecessary for signaling and morphological responses...
  71. pmc Fv-2 locus controls expression of Friend spleen focus-forming virus-specific sequences in normal and infected mice
    T W Mak
    Proc Natl Acad Sci U S A 76:5809-12. 1979
    ..In addition, the finding that the Fv-2 gene locus controls the expression of endogenous SFFV-related sequences suggests that these sequences may also be involved in normal hemopoiesis...
  72. ncbi Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function
    Karla Ann Hess
    Divisions of Developmental Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Biol Reprod 68:1267-75. 2003
    b>Ron is a receptor tyrosine kinase that is activated by the binding of hepatocyte growth factor-like (HGFL) protein. Mutations in the catalytic domain of this receptor result in an aggressively invasive phenotype...
  73. ncbi Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons
    Alison Forgie
    Department of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, Summerhall Square, Edinburgh EH9 1QH, Scotland
    Development 130:995-1002. 2003
    Macrophage stimulating protein (MSP) is a pleiotropic growth factor that signals via the Ron receptor tyrosine kinase...
  74. ncbi A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells
    Edward Melkun
    Department of Veterinary Science, The Schreyer s Honors College, and the Graduate Program in Biochemistry, Microbiology and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Blood 100:3804-11. 2002
    The Friend virus susceptibility gene 2 (Fv2) controls the polyclonal expansion of infected cells that occurs early during Friend erythroleukemia virus infection...
  75. ncbi Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages
    Yong Qing Zhou
    Division of Neurosurgery, The First Affiliated Teaching Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People s Republic of China
    J Biol Chem 277:38104-10. 2002
    The RON receptor tyrosine kinase is activated by macrophage-stimulating protein, which regulates macrophage migration, phagocytosis, and nitric oxide production...
  76. ncbi Feline STK gene expression in mammary carcinomas
    Raffaella De Maria
    Comparative Oncology Center, Institute for Cancer Research and Treatment, University of Torino, SP 142, Km 3 95, 10060 Candiolo Torino Italy
    Oncogene 21:1785-90. 2002
    The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas...
  77. ncbi Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    D A Persons
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 23:159-65. 1999
    The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1...
  78. pmc The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse
    R S Muraoka
    Graduate Program in Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 103:1277-85. 1999
    The Ron/STK receptor tyrosine kinase is a member of the c-Met family of receptors and is activated by hepatocyte growth factor-like protein (HGFL)...
  79. ncbi Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase
    P H Correll
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Funct 1:69-83. 1997
    ..b>STK, the murine homologue of the human RON receptor tyrosine kinase, is expressed on murine resident peritoneal ..
  80. ncbi Construction of a D2.B6-Fv-2r congenic mouse strain: nonlethality of the homozygous Fv-2' genotype
    M Dizik
    J Natl Cancer Inst 66:755-60. 1981
    ..B6-Fv-2r genome, as shown by the continued presence of C57BL/6 alleles at the flanking Kfo-1 and Bgl-s loci. The observed recombination frequency for the intervals between Fv-2 and Bgl-s was 6.8%...
  81. ncbi A genetic linkage map of the mouse chromosome 9 region encompassing the Friend virus susceptibility gene 2
    R F Paulson
    Program in Molecular Biology and Cancer, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 983, Toronto, Ontario M5G 1X5, Canada
    Mamm Genome 9:381-4. 1998
  82. ncbi Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells
    J Barclay
    Department of Paediatrics and Child Health, Royal Free and University College Medical School, The Rayne Institute, London, WC1E 6JJ, United Kingdom
    J Neurosci 21:6095-104. 2001
    ..Our observations document the first mammalian alpha2delta mutation and complete the association of each of the major classes of voltage-dependent Ca(2+) channel subunits with a phenotype of ataxia and epilepsy in the mouse...
  83. ncbi Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
    Fudi Wang
    Division of Hematology Oncology, Children s Hospital Boston, Boston, Massachusetts, 02115 USA
    Nat Genet 39:1025-32. 2007
    ..Mon1a is also important for trafficking of cell-surface and secreted molecules unrelated to iron metabolism, suggesting that it has a fundamental role in the mammalian secretory apparatus...
  84. pmc The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk
    K Nishigaki
    Basic Research Laboratory, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Virol 75:7893-903. 2001
    ..by the host gene Fv-2, which was recently shown to be identical to the gene encoding the receptor tyrosine kinase Stk/Ron...
  85. ncbi Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity
    J M Friedman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 5:463-9. 1989
    ....
  86. ncbi Ras-like genes and gene families in the mouse
    G Drivas
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mamm Genome 1:112-7. 1991
    ..Two possible clusters of Ras-like and/or G protein genes were identified, on Chrs 9 and 17...
  87. ncbi Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor
    Belinda E Peace
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Exp Cell Res 289:317-25. 2003
    ..Accordingly, the interaction of two dissimilar tyrosine kinase receptors, Ron and epidermal growth factor receptor (EGFR) was investigated...
  88. ncbi Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages
    Amy C Morrison
    Department of Veterinary Science and Graduate Program in Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 168:853-60. 2002
    ..lab and others have previously shown that macrophage-stimulating protein (MSP), through activation of its receptor RON, negatively regulates NO production in response to IFN-gamma and LPS by inhibiting the expression of inducible NO ..
  89. pmc Inheritance of susceptibility to Friend mouse leukemia virus. V. Introduction of a gene responsible for susceptibility in the genetic complement of resistant mice
    T Odaka
    J Virol 3:543-8. 1969
    ..The results indicate that the appearance of early splenomegaly in Friend virus-infected mice is under the control of a single major autosomal gene...
  90. ncbi Activation of CR3-mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, phosphatidylinositol 3-kinase, and protein kinase C zeta
    Michael A Lutz
    Department of Veterinary Science, Pennsylvania State University, Pathobiology Graduate Program, University Park 16802, USA
    J Leukoc Biol 73:802-14. 2003
    ..We show that MSP-induced complement-mediated phagocytosis requires the RON receptor tyrosine kinase and the alphaMbeta2 integrin, as evidenced by the inability of RON-/- and alphaM-/- ..

Research Grants5

  1. HEPATOCYTE GROWTH FACTOR LIKE PROTEIN RECEPTOR
    Susan Waltz; Fiscal Year: 2003
    The long term goal of this proposal is to determine the in vivo function of the tyrosine kinase receptor known as Ron. Based on in vitro analyses, Ron has been postulated to have a critical role in cellular proliferation, dissociation ..
  2. Research in Alimentary Tract Surgery
    Susan Waltz; Fiscal Year: 2007
    ..D. trainees should be competitive for entry-level independent funding. ..
  3. The Ron Receptor in Mammary Gland Biology
    Susan Waltz; Fiscal Year: 2008
    ..by applicant): The long-term objective of my research is to define the in vivo role of the receptor tyrosine kinase Ron in mammary gland biology. Virtually nothing is known regarding the function of Ron in the breast...
  4. Hepatocyte Growth Factor-like Protein Receptor
    Susan Waltz; Fiscal Year: 2009
    ..applicant): The long-term objective of my research is to define the in vivo role of the receptor tyrosine kinase Ron in liver pathophysiology. Virtually nothing is known regarding the function of Ron in the liver...
  5. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..