Genomes and Genes
Gene Symbol: Mst1
Description: macrophage stimulating 1 (hepatocyte growth factor-like)
Alias: D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl, hepatocyte growth factor-like protein, MSP, macrophage stimulatory protein
- Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesionKoko Katagiri
Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Osaka 570 8506, Japan
Nat Immunol 7:919-28. 2006..Here we have identified the kinase Mst1 as a critical effector of RAPL. RAPL regulated the localization and kinase activity of Mst1...
- Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymusYoshihiro Ueda
Department of Molecular Genetics, Institute of Biomedical Science, 10 15 Fumizono cho, Osaka 570 8506, Japan
Nat Commun 3:1098. 2012Thymocyte trafficking has an important role in thymic selection. Here we show that the Hippo homologue Mst1 is required for thymocyte migration and antigen recognition by LFA-1 and ICAM-1 within the medulla...
- MST1 functions as a key modulator of neurodegeneration in a mouse model of ALSJae Keun Lee
Laboratory of Cell Death and Human Diseases, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
Proc Natl Acad Sci U S A 110:12066-71. 2013..Here we show that genetic deficiency of mammalian sterile 20-like kinase 1 (MST1) delays disease onset and extends survival in mice expressing the ALS-associated G93A mutant of human SOD1...
- The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytesFan Mou
Department of Molecular Biology, Massachusetts GeneralHospital, Boston, MA 02114, USA
J Exp Med 209:741-59. 2012The Mst1 kinase is an important regulator of murine T cell adhesion, migration, proliferation, and apoptosis. In this study, we analyze mice lacking both Mst1 and Mst2 in hematopoietic cells...
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liverLi Lu
Department of Biochemistry and Molecular Biology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:1437-42. 2010..the role of hippo signaling in regulation of mammalian organ size we have generated conditional alleles of Sav1, mst1, and mst2, orthologs of Drosophila Salvador and hippo, respectively...
- Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppressionHai Song
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:1431-6. 2010..We found that Mst1 and Mst2, the two mouse homologs of the Drosophila Hpo, control the sizes of some, but not all organs, in mice, and ..
- Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in miceJuhyun Choi
Department of Biological Sciences, National Research Laboratory of Molecular Genetics, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
PLoS ONE 4:e8011. 2009..In C. elegans, Hippo homolog also regulates longevity. The mammalian Ste20-like protein kinase, Mst1, plays a role in apoptosis induced by various types of apoptotic stress...
- A cell-intrinsic role for Mst1 in regulating thymocyte egressYongli Dong
Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
J Immunol 183:3865-72. 2009The MST1 kinase was recently identified as playing an essential role in the promotion of lymphocyte polarization and adhesion stimulated by chemokines and TCR signaling...
- Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodesKoko Katagiri
Department of Molecular Genetics, Kansai Medical University, Fumizono cho, Moriguchi City, Osaka, Japan
EMBO J 28:1319-31. 2009..Here, we show that the Ste20-like kinase Mst1 plays crucial roles in lymphocyte trafficking in vivo...
- The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cellsDawang Zhou
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 105:20321-6. 2008The Mst1 and Mst2 protein kinases are the mammalian homologs of hippo, a major inhibitor of cell proliferation in Drosophila. Mst1 is most abundant in lymphoid tissues...
- MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferationMaria Praskova
Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Curr Biol 18:311-21. 2008b>MST1 and MST2 are the mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development...
- Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarctionMari Odashima
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
Circ Res 100:1344-52. 2007Mammalian sterile 20-like kinase-1 (Mst1) plays an important role in mediating cardiac myocyte apoptosis in response to ischemia/reperfusion...
- Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharideAmy C Morrison
Department of Veterinary Science, Graduate Program in Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 172:1825-32. 2004..We have shown previously that macrophage-stimulating protein (MSP), the ligand for the stem cell-derived tyrosine kinase/recepteur d'origine nantais (RON) receptor, inhibits NO ..
- The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissuesG Gaudino
Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
Oncogene 11:2627-37. 1995..showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages...
- Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3T Yoshimura
Immunopathology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702
J Biol Chem 268:15461-8. 1993..hepatoma (HepG2) cell line library was screened with an oligonucleotide probe for macrophage stimulating protein (MSP) to clone an MSP cDNA. Deduced sequences of isolated clones were compared with peptide fragment sequences of MSP...
- Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xLDominic P Del Re
Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
Mol Cell 54:639-50. 2014..The core component of this cascade, Mst1 in mammalian cells, is sufficient to promote apoptosis...
- Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in miceChao Geng
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College, 5 Dongdansantiao, Beijing 100005, China
Biochem Biophys Res Commun 471:444-9. 2016Previous study showed mammalian Ste20-like kinase (Mst1) may serve as target for the development of new therapies for diabetes. However, the function of Mst1 involved in liver lipid metabolism has remained elusive...
- Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk alleleSteven E Kauder
Discovery Immunology, Genentech Inc, South San Francisco, California, United States of America
PLoS ONE 8:e83958. 2013Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON)...
- Genetic deletion of Mst1 alters T cell function and protects against autoimmunityKonstantin V Salojin
Lexicon Pharmaceuticals, Inc, The Woodlands, Texas, United States of America
PLoS ONE 9:e98151. 2014Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking...
- Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesisDevikala Gurusamy
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
Mech Dev 133:11-22. 2014..Hepatocyte growth factor-like protein [HGFL] is the only known ligand for the Ron receptor and recent studies have identified major roles for HGFL during ..
- Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte traffickingAkihiko Nishikimi
Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0373, Japan
Sci Signal 7:ra72. 2014In lymphocytes, the kinase Mst1 is required for the proper organization of integrins in the plasma membrane at the leading edge of migrating cells, which is critical for lymphocyte trafficking...
- Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migrationXiaolu Xu
Department of Pathology and Immunology, Washington University, St Louis, Missouri, United States of America
PLoS ONE 9:e105561. 2014..b>Mst1 kinase is a key signal mediator required for both of these processes; however, its molecular mechanism remains ..
- Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion diseaseRory H Shott
Department of Biochemistry and Centre for Prions and Protein Folding Diseases CPPFD, University of Alberta, Edmonton, AB, Canada
Virol J 11:160. 2014..Here, we used this approach to identify signaling pathways dysregulated during prion pathogenesis in vivo...
- Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in miceCheng Xiang
Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China
Cell Physiol Biochem 35:957-68. 2015..It has been reported that the members of Hippo signaling are expressed in mammalian ovaries, but the exact functions of this pathway in primordial follicle development remains unclear...
- Functional role of Mst1/Mst2 in embryonic stem cell differentiationPeng Li
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
PLoS ONE 8:e79867. 2013..b>Mst1 and Mst2 are central components of this pathway that are essential for embryonic development, though their role in ..
- Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2Yasuhiro Maejima
1 Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA 2 Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Nat Med 19:1478-88. 2013Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy...
- mTORC2 regulates cardiac response to stress by inhibiting MST1Sebastiano Sciarretta
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA IRCCS Neuromed, Pozzilli 86077, Italy
Cell Rep 11:125-36. 2015..Here, we demonstrate that mTORC2 is a direct negative regulator of the MST1 kinase, a key component of the Hippo pathway...
- Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 AcetylationJiang Li
the Obstetrics and Gynecology Hospital and Institute of Reproduction and Development, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China, and From the Institute of Developmental Biology and Molecular Medicine, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China
J Biol Chem 290:30762-70. 2015..Here we report that Mst1 can enhance Foxp3 stability, its transcriptional activity, and Treg function by modulating the Foxp3 protein at the ..
- TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1Kyung Hye Roh
Laboratory of Cell Death and Human Diseases, Department of Life Sciences, Korea University, Seoul 02841, South Korea
Free Radic Biol Med 91:105-13. 2016..In particular, excessive ROS causes oxidative stress that leads to cell death. The mammalian STE20-like kinase-1 (MST1), a multifunctional serine-threonine kinase, plays a pivotal role in oxidative stress-induced cellular signaling ..
- Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosisBei You
Institute of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
PLoS ONE 8:e58697. 2013Mammalian sterile 20-like kinase 1 (Mst1) is a critical component of the Hippo signaling pathway, which regulates a variety of biological processes ranging from cell contact inhibition, organ size control, apoptosis and tumor suppression ..
- Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregationTae Shin Kim
Authors Affiliations Department of Biological Sciences, National Creative Research Initiatives Center, Graduate School of Nanoscience and Technology WCU, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Cancer Res 72:5386-95. 2012..Mammalian sterile 20-like kinase 1 (MST1), the core component of the Hippo signaling pathway, is highly expressed in hematopoietic cells...
- Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1Ji Soo Chae
Laboratory of Cell Death and Human Diseases, School of Life Sciences, South Korea
Free Radic Biol Med 53:2335-43. 2012The mammalian STE20-like kinase-1 (MST1), a multifunctional serine-threonine kinase in mammalian cells, has been recently implicated in the mediation of oxidative stress-induced signaling processes that lead to cell death...
- Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9S J Degen
Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
Genomics 13:1368-9. 1992The gene coding for hepatocyte growth factor-like protein has been localized to mouse chromosome 9 at a locus (Hgfl) distal to the Trf locus. The likely gene order in this region is centromere-Trf-Gnai-2-Hgfl-Cck...
- Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during developmentS J Degen
Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
Biochemistry 30:9781-91. 1991..It is apparent that the majority of mRNA coding for HGF-like protein is expressed in liver. Messenger RNA is also expressed at a lower level in lung, adrenal, and placenta...
- Assignment of 22 loci in the rat by somatic hybrid and linkage analysisR S Yeung
Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
Mamm Genome 4:585-8. 1993..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human...
- cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the geneK Li
Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Genomics 16:733-9. 1993..This assignment confirms and extends the relationship between the mouse and the human chromosomes in this region of the genome...
- Hepatocyte-specific expression of the mouse hepatocyte growth factor-like proteinJ A Bezerra
Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 2899
Hepatology 18:394-9. 1993..We conclude that although structurally similar to hepatocyte growth factor, hepatocyte growth factor-like protein is a novel protein synthesized primarily in hepatocytes...
- Biological effects of targeted inactivation of hepatocyte growth factor-like protein in miceJ A Bezerra
Division of Gastroenterology and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 101:1175-83. 1998Hepatocyte growth factor-like protein (HGFL) is a liver-derived serum glycoprotein involved in cell proliferation and differentiation, and is proposed to have a fundamental role in embryogenesis, fertility, hematopoiesis, macrophage ..
- The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouseR S Muraoka
Graduate Program in Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 103:1277-85. 1999..kinase is a member of the c-Met family of receptors and is activated by hepatocyte growth factor-like protein (HGFL)...
- Fv2 encodes a truncated form of the Stk receptor tyrosine kinaseD A Persons
Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nat Genet 23:159-65. 1999..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
- Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neuronsAlison Forgie
Department of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, Summerhall Square, Edinburgh EH9 1QH, Scotland
Development 130:995-1002. 2003Macrophage stimulating protein (MSP) is a pleiotropic growth factor that signals via the Ron receptor tyrosine kinase...
- Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell functionKarla Ann Hess
Divisions of Developmental Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
Biol Reprod 68:1267-75. 2003Ron is a receptor tyrosine kinase that is activated by the binding of hepatocyte growth factor-like (HGFL) protein. Mutations in the catalytic domain of this receptor result in an aggressively invasive phenotype...
- Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cellsHami E Teal
Graduate Program in Pathobiology, Department of Veterinary Science, Pennsylvania State University, University Park 16802, USA
J Hematother Stem Cell Res 12:165-77. 2003..In this report, we show that macrophage-stimulating protein (MSP), the ligand for full-length STK, can also cooperate with Epo to enhance burst-forming units-erythroid (BFU-E) ..
- Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholismRoberto Ciccocioppo
Department of Experimental Medicine and Public Heath, University of Camerino, MC, Italy
Addict Biol 11:339-55. 2006..review summarizing almost 18 years of research in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats...
- Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating proteinManujendra Ray
Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
J Immunol 185:7309-16. 2010..In primary macrophages, the ligand for Ron, macrophage-stimulating protein (MSP), inhibits the expression of inducible NO synthase, a marker of classically activated macrophages, whereas ..
- Daxx mediates activation-induced cell death in microglia by triggering MST1 signallingHee Jae Yun
School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
EMBO J 30:2465-76. 2011..Here, we show that Daxx and mammalian Ste20-like kinase-1 (MST1) mediate apoptosis elicited by interferon-γ (IFN-γ) in microglia...