Mst1

Summary

Gene Symbol: Mst1
Description: macrophage stimulating 1 (hepatocyte growth factor-like)
Alias: D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl, hepatocyte growth factor-like protein, MSP, macrophage stimulatory protein
Species: mouse

Top Publications

  1. ncbi Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
    Koko Katagiri
    Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Osaka 570 8506, Japan
    Nat Immunol 7:919-28. 2006
  2. doi Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus
    Yoshihiro Ueda
    Department of Molecular Genetics, Institute of Biomedical Science, 10 15 Fumizono cho, Osaka 570 8506, Japan
    Nat Commun 3:1098. 2012
  3. pmc MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS
    Jae Keun Lee
    Laboratory of Cell Death and Human Diseases, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Proc Natl Acad Sci U S A 110:12066-71. 2013
  4. pmc The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
    Fan Mou
    Department of Molecular Biology, Massachusetts GeneralHospital, Boston, MA 02114, USA
    J Exp Med 209:741-59. 2012
  5. pmc Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    Li Lu
    Department of Biochemistry and Molecular Biology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:1437-42. 2010
  6. pmc Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    Hai Song
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:1431-6. 2010
  7. pmc Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice
    Juhyun Choi
    Department of Biological Sciences, National Research Laboratory of Molecular Genetics, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    PLoS ONE 4:e8011. 2009
  8. doi A cell-intrinsic role for Mst1 in regulating thymocyte egress
    Yongli Dong
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    J Immunol 183:3865-72. 2009
  9. pmc Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
    Koko Katagiri
    Department of Molecular Genetics, Kansai Medical University, Fumizono cho, Moriguchi City, Osaka, Japan
    EMBO J 28:1319-31. 2009
  10. pmc The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:20321-6. 2008

Scientific Experts

  • Luis María Schang
  • Roberto Ciccocioppo
  • J A Bezerra
  • Dae Sik Lim
  • Koko Katagiri
  • Dominic P Del Re
  • Yasuhiro Maejima
  • Eui Ju Choi
  • Junichi Sadoshima
  • Tatsuo Kinashi
  • Maria Praskova
  • Sebastiano Sciarretta
  • Hong Li
  • Peiyong Zhai
  • Tong Liu
  • Wufan Tao
  • Jae Keun Lee
  • Sang Gil Hwang
  • Ji Soo Chae
  • Yoshihiro Ueda
  • Joseph Avruch
  • Dawang Zhou
  • Manujendra Ray
  • Chao Geng
  • Kyung Hye Roh
  • Jiang Li
  • Cheng Xiang
  • Akihiko Nishikimi
  • Xiaolu Xu
  • Konstantin V Salojin
  • Devikala Gurusamy
  • Rory H Shott
  • Chiao Po Hsu
  • Steven E Kauder
  • Bei You
  • Peng Li
  • Fan Mou
  • Xingrong Du
  • Tae Shin Kim
  • Kinglun Kingston Mak
  • Hee Jae Yun
  • Tomoya Katakai
  • Fan Xia
  • Li Lu
  • Hyun Jung Oh
  • Hai Song
  • Pamela H Correll
  • Juhyun Choi
  • Yongli Dong
  • Susan E Waltz
  • Caleph B Wilson
  • Mari Odashima
  • Amy C Morrison
  • Alison Forgie
  • Yong Gao
  • Fude Fang
  • Yinliang Zhang
  • Xiaojun Liu
  • Yongsheng Chang
  • Huabing Zhang
  • Karla Ann Hess
  • Hami E Teal
  • Giacomo Frati
  • Derek Yee
  • Narayani Nagarajan
  • Jian Huang
  • Zhisheng Zhong
  • Liaoliao Hu
  • Hao Shi
  • Hongbo Chi
  • Yuehui Zheng
  • Mark A Magnuson
  • Jia Li
  • Tao Luo
  • Liping Zheng
  • Kejing Deng
  • Massimo Volpe
  • Nancy L Mathis
  • John R Walker
  • Anna Majer
  • Dana A Smith
  • Amin Al-Shami
  • Serge Batalov
  • Abby L Johnson
  • Emily R Jaeger
  • Karsten Sauer
  • Robert Read
  • Tim Wiltshire
  • Sayaka Ishihara
  • Wei Chun Chang

Detail Information

Publications46

  1. ncbi Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
    Koko Katagiri
    Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Osaka 570 8506, Japan
    Nat Immunol 7:919-28. 2006
    ..Here we have identified the kinase Mst1 as a critical effector of RAPL. RAPL regulated the localization and kinase activity of Mst1...
  2. doi Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus
    Yoshihiro Ueda
    Department of Molecular Genetics, Institute of Biomedical Science, 10 15 Fumizono cho, Osaka 570 8506, Japan
    Nat Commun 3:1098. 2012
    Thymocyte trafficking has an important role in thymic selection. Here we show that the Hippo homologue Mst1 is required for thymocyte migration and antigen recognition by LFA-1 and ICAM-1 within the medulla...
  3. pmc MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS
    Jae Keun Lee
    Laboratory of Cell Death and Human Diseases, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Proc Natl Acad Sci U S A 110:12066-71. 2013
    ..Here we show that genetic deficiency of mammalian sterile 20-like kinase 1 (MST1) delays disease onset and extends survival in mice expressing the ALS-associated G93A mutant of human SOD1...
  4. pmc The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
    Fan Mou
    Department of Molecular Biology, Massachusetts GeneralHospital, Boston, MA 02114, USA
    J Exp Med 209:741-59. 2012
    The Mst1 kinase is an important regulator of murine T cell adhesion, migration, proliferation, and apoptosis. In this study, we analyze mice lacking both Mst1 and Mst2 in hematopoietic cells...
  5. pmc Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    Li Lu
    Department of Biochemistry and Molecular Biology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:1437-42. 2010
    ..the role of hippo signaling in regulation of mammalian organ size we have generated conditional alleles of Sav1, mst1, and mst2, orthologs of Drosophila Salvador and hippo, respectively...
  6. pmc Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    Hai Song
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:1431-6. 2010
    ..We found that Mst1 and Mst2, the two mouse homologs of the Drosophila Hpo, control the sizes of some, but not all organs, in mice, and ..
  7. pmc Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice
    Juhyun Choi
    Department of Biological Sciences, National Research Laboratory of Molecular Genetics, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    PLoS ONE 4:e8011. 2009
    ..In C. elegans, Hippo homolog also regulates longevity. The mammalian Ste20-like protein kinase, Mst1, plays a role in apoptosis induced by various types of apoptotic stress...
  8. doi A cell-intrinsic role for Mst1 in regulating thymocyte egress
    Yongli Dong
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    J Immunol 183:3865-72. 2009
    The MST1 kinase was recently identified as playing an essential role in the promotion of lymphocyte polarization and adhesion stimulated by chemokines and TCR signaling...
  9. pmc Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
    Koko Katagiri
    Department of Molecular Genetics, Kansai Medical University, Fumizono cho, Moriguchi City, Osaka, Japan
    EMBO J 28:1319-31. 2009
    ..Here, we show that the Ste20-like kinase Mst1 plays crucial roles in lymphocyte trafficking in vivo...
  10. pmc The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:20321-6. 2008
    The Mst1 and Mst2 protein kinases are the mammalian homologs of hippo, a major inhibitor of cell proliferation in Drosophila. Mst1 is most abundant in lymphoid tissues...
  11. pmc MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
    Maria Praskova
    Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Biol 18:311-21. 2008
    b>MST1 and MST2 are the mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development...
  12. ncbi Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction
    Mari Odashima
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Circ Res 100:1344-52. 2007
    Mammalian sterile 20-like kinase-1 (Mst1) plays an important role in mediating cardiac myocyte apoptosis in response to ischemia/reperfusion...
  13. ncbi Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide
    Amy C Morrison
    Department of Veterinary Science, Graduate Program in Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 172:1825-32. 2004
    ..We have shown previously that macrophage-stimulating protein (MSP), the ligand for the stem cell-derived tyrosine kinase/recepteur d'origine nantais (RON) receptor, inhibits NO ..
  14. ncbi The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues
    G Gaudino
    Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
    Oncogene 11:2627-37. 1995
    ..showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages...
  15. ncbi Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3
    T Yoshimura
    Immunopathology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702
    J Biol Chem 268:15461-8. 1993
    ..hepatoma (HepG2) cell line library was screened with an oligonucleotide probe for macrophage stimulating protein (MSP) to clone an MSP cDNA. Deduced sequences of isolated clones were compared with peptide fragment sequences of MSP...
  16. pmc Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL
    Dominic P Del Re
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
    Mol Cell 54:639-50. 2014
    ..The core component of this cascade, Mst1 in mammalian cells, is sufficient to promote apoptosis...
  17. doi Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice
    Chao Geng
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College, 5 Dongdansantiao, Beijing 100005, China
    Biochem Biophys Res Commun 471:444-9. 2016
    Previous study showed mammalian Ste20-like kinase (Mst1) may serve as target for the development of new therapies for diabetes. However, the function of Mst1 involved in liver lipid metabolism has remained elusive...
  18. pmc Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele
    Steven E Kauder
    Discovery Immunology, Genentech Inc, South San Francisco, California, United States of America
    PLoS ONE 8:e83958. 2013
    Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON)...
  19. pmc Genetic deletion of Mst1 alters T cell function and protects against autoimmunity
    Konstantin V Salojin
    Lexicon Pharmaceuticals, Inc, The Woodlands, Texas, United States of America
    PLoS ONE 9:e98151. 2014
    Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking...
  20. pmc Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis
    Devikala Gurusamy
    Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Mech Dev 133:11-22. 2014
    ..Hepatocyte growth factor-like protein [HGFL] is the only known ligand for the Ron receptor and recent studies have identified major roles for HGFL during ..
  21. doi Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking
    Akihiko Nishikimi
    Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0373, Japan
    Sci Signal 7:ra72. 2014
    In lymphocytes, the kinase Mst1 is required for the proper organization of integrins in the plasma membrane at the leading edge of migrating cells, which is critical for lymphocyte trafficking...
  22. pmc Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration
    Xiaolu Xu
    Department of Pathology and Immunology, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 9:e105561. 2014
    ..b>Mst1 kinase is a key signal mediator required for both of these processes; however, its molecular mechanism remains ..
  23. pmc Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease
    Rory H Shott
    Department of Biochemistry and Centre for Prions and Protein Folding Diseases CPPFD, University of Alberta, Edmonton, AB, Canada
    Virol J 11:160. 2014
    ..Here, we used this approach to identify signaling pathways dysregulated during prion pathogenesis in vivo...
  24. doi Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice
    Cheng Xiang
    Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China
    Cell Physiol Biochem 35:957-68. 2015
    ..It has been reported that the members of Hippo signaling are expressed in mammalian ovaries, but the exact functions of this pathway in primordial follicle development remains unclear...
  25. pmc Functional role of Mst1/Mst2 in embryonic stem cell differentiation
    Peng Li
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    PLoS ONE 8:e79867. 2013
    ..b>Mst1 and Mst2 are central components of this pathway that are essential for embryonic development, though their role in ..
  26. pmc Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
    Yasuhiro Maejima
    1 Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA 2 Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Med 19:1478-88. 2013
    Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy...
  27. pmc mTORC2 regulates cardiac response to stress by inhibiting MST1
    Sebastiano Sciarretta
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA IRCCS Neuromed, Pozzilli 86077, Italy
    Cell Rep 11:125-36. 2015
    ..Here, we demonstrate that mTORC2 is a direct negative regulator of the MST1 kinase, a key component of the Hippo pathway...
  28. pmc Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation
    Jiang Li
    the Obstetrics and Gynecology Hospital and Institute of Reproduction and Development, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China, and From the Institute of Developmental Biology and Molecular Medicine, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China
    J Biol Chem 290:30762-70. 2015
    ..Here we report that Mst1 can enhance Foxp3 stability, its transcriptional activity, and Treg function by modulating the Foxp3 protein at the ..
  29. doi TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1
    Kyung Hye Roh
    Laboratory of Cell Death and Human Diseases, Department of Life Sciences, Korea University, Seoul 02841, South Korea
    Free Radic Biol Med 91:105-13. 2016
    ..In particular, excessive ROS causes oxidative stress that leads to cell death. The mammalian STE20-like kinase-1 (MST1), a multifunctional serine-threonine kinase, plays a pivotal role in oxidative stress-induced cellular signaling ..
  30. pmc Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis
    Bei You
    Institute of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
    PLoS ONE 8:e58697. 2013
    Mammalian sterile 20-like kinase 1 (Mst1) is a critical component of the Hippo signaling pathway, which regulates a variety of biological processes ranging from cell contact inhibition, organ size control, apoptosis and tumor suppression ..
  31. doi Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation
    Tae Shin Kim
    Authors Affiliations Department of Biological Sciences, National Creative Research Initiatives Center, Graduate School of Nanoscience and Technology WCU, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Cancer Res 72:5386-95. 2012
    ..Mammalian sterile 20-like kinase 1 (MST1), the core component of the Hippo signaling pathway, is highly expressed in hematopoietic cells...
  32. doi Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1
    Ji Soo Chae
    Laboratory of Cell Death and Human Diseases, School of Life Sciences, South Korea
    Free Radic Biol Med 53:2335-43. 2012
    The mammalian STE20-like kinase-1 (MST1), a multifunctional serine-threonine kinase in mammalian cells, has been recently implicated in the mediation of oxidative stress-induced signaling processes that lead to cell death...
  33. ncbi Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9
    S J Degen
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
    Genomics 13:1368-9. 1992
    The gene coding for hepatocyte growth factor-like protein has been localized to mouse chromosome 9 at a locus (Hgfl) distal to the Trf locus. The likely gene order in this region is centromere-Trf-Gnai-2-Hgfl-Cck...
  34. ncbi Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development
    S J Degen
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
    Biochemistry 30:9781-91. 1991
    ..It is apparent that the majority of mRNA coding for HGF-like protein is expressed in liver. Messenger RNA is also expressed at a lower level in lung, adrenal, and placenta...
  35. ncbi Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
    R S Yeung
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
    Mamm Genome 4:585-8. 1993
    ..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human...
  36. ncbi cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene
    K Li
    Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Genomics 16:733-9. 1993
    ..This assignment confirms and extends the relationship between the mouse and the human chromosomes in this region of the genome...
  37. ncbi Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein
    J A Bezerra
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 2899
    Hepatology 18:394-9. 1993
    ..We conclude that although structurally similar to hepatocyte growth factor, hepatocyte growth factor-like protein is a novel protein synthesized primarily in hepatocytes...
  38. pmc Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice
    J A Bezerra
    Division of Gastroenterology and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 101:1175-83. 1998
    Hepatocyte growth factor-like protein (HGFL) is a liver-derived serum glycoprotein involved in cell proliferation and differentiation, and is proposed to have a fundamental role in embryogenesis, fertility, hematopoiesis, macrophage ..
  39. pmc The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse
    R S Muraoka
    Graduate Program in Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 103:1277-85. 1999
    ..kinase is a member of the c-Met family of receptors and is activated by hepatocyte growth factor-like protein (HGFL)...
  40. ncbi Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    D A Persons
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 23:159-65. 1999
    ..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
  41. ncbi Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons
    Alison Forgie
    Department of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, Summerhall Square, Edinburgh EH9 1QH, Scotland
    Development 130:995-1002. 2003
    Macrophage stimulating protein (MSP) is a pleiotropic growth factor that signals via the Ron receptor tyrosine kinase...
  42. ncbi Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function
    Karla Ann Hess
    Divisions of Developmental Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Biol Reprod 68:1267-75. 2003
    Ron is a receptor tyrosine kinase that is activated by the binding of hepatocyte growth factor-like (HGFL) protein. Mutations in the catalytic domain of this receptor result in an aggressively invasive phenotype...
  43. ncbi Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells
    Hami E Teal
    Graduate Program in Pathobiology, Department of Veterinary Science, Pennsylvania State University, University Park 16802, USA
    J Hematother Stem Cell Res 12:165-77. 2003
    ..In this report, we show that macrophage-stimulating protein (MSP), the ligand for full-length STK, can also cooperate with Epo to enhance burst-forming units-erythroid (BFU-E) ..
  44. pmc Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Heath, University of Camerino, MC, Italy
    Addict Biol 11:339-55. 2006
    ..review summarizing almost 18 years of research in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats...
  45. pmc Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein
    Manujendra Ray
    Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 185:7309-16. 2010
    ..In primary macrophages, the ligand for Ron, macrophage-stimulating protein (MSP), inhibits the expression of inducible NO synthase, a marker of classically activated macrophages, whereas ..
  46. pmc Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling
    Hee Jae Yun
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    EMBO J 30:2465-76. 2011
    ..Here, we show that Daxx and mammalian Ste20-like kinase-1 (MST1) mediate apoptosis elicited by interferon-γ (IFN-γ) in microglia...