Mpi

Summary

Gene Symbol: Mpi
Description: mannose phosphate isomerase
Alias: 1110002E17Rik, AI315153, Mpi-1, Mpi1, mannose-6-phosphate isomerase, PMI, mannose phosphate isomerase 1, phosphohexomutase, phosphomannose isomerase
Species: mouse

Top Publications

  1. doi The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells
    Naonobu Fujita
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Japan
    FEBS J 275:788-98. 2008
  2. pmc Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice
    Vandana Sharma
    2Sanford Burnham Medical Research Institute SBMRI, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    FASEB J 28:1854-69. 2014
  3. pmc Metabolically programmed quality control system for dolichol-linked oligosaccharides
    Yoichiro Harada
    Glycometabolome Team, Systems Glycobiology Research Group and Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN Max Planck Joint Research Center, Global Research Cluster, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 110:19366-71. 2013
  4. pmc Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9
    R H Tukey
    Proc Natl Acad Sci U S A 81:3163-6. 1984
  5. pmc Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains
    C A Kozak
    J Exp Med 155:524-34. 1982
  6. ncbi [Presence of a male sterility factor, Hst-2, segregating in interspecies crosses. M. musculus L. x M. spretus Lastaste and linked to Mod-1, and Mpi-1 on chromosome 9]
    F Bonhomme
    C R Seances Acad Sci III 294:691-3. 1982
  7. ncbi Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 21:37-48. 1983
  8. pmc Application of the ovarian teratoma mapping method in the mouse
    J T Eppig
    Genetics 103:797-812. 1983
  9. ncbi A serum protein polymorphism determinant on chromosome 9 of Mus musculus
    E M Eicher
    Mol Gen Genet 177:571-6. 1980
  10. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982

Scientific Experts

  • Hudson H Freeze
  • Maria Liljander
  • Charles DeRossi
  • Ling Wang
  • Vandana Sharma
  • Yoichiro Harada
  • Mecedes Cano
  • Joseph A Davis
  • Naonobu Fujita
  • Amanda H McDaniel
  • Vibeke Westphal
  • Cherise M Guess
  • Joseph Russell
  • Emily Contreras
  • Anand Srivastava
  • Ping He
  • Stan Krajewski
  • Bobby G Ng
  • Adriana Charbono
  • Mie Ichikawa
  • Jonamani Nayak
  • David A Scott
  • Erika Grajales-Esquivel
  • Katia Del Rio-Tsonis
  • Tadashi Suzuki
  • Kazuki Nakajima
  • Takashi Angata
  • Yuki Masahara-Negishi
  • Naoyuki Taniguchi
  • Anunciación A Ilundáin
  • Ayako Tamura
  • Takashi Tonozuka
  • Atsushi Nishikawa
  • Aya Higashidani
  • Lars Bode
  • Danielle R Reed
  • Fangrong Zhang
  • Michael G Tordoff
  • Alexander D Borowsky
  • C A Kozak
  • L Yan
  • Xia Li
  • Erik A Eklund
  • Alexander A Bachmanov
  • Xiao Hua Wu
  • Gordon Alton
  • Rongrong Wu
  • Geetha Srikrishna
  • R M Weinshilboum
  • D M Otterness
  • D Simon-Chazottes
  • J L Guenet
  • P A Lalley
  • U Francke
  • E Kobayashi
  • K R Johnson
  • B A Taylor
  • J D Minna
  • I Cloez-Tayarani
  • E M Eicher
  • G Fillion
  • F H Ruddle
  • M P Fillion
  • T Kunieda
  • R L Stallings
  • C Kozak
  • S A Cook
  • M Bustin
  • A Groen
  • S J O'Brien
  • M Tachibana
  • H Ikadai
  • A Bessis
  • V L Morris
  • H Satoh
  • M T Davisson
  • J Otto
  • S Tutois
  • A L Beaudet
  • T C Douglas
  • E A Nichols
  • J T Eppig
  • T Imamichi
  • D Bergeron
  • F Bonhomme
  • S L Frank
  • C M Ballantyne
  • T K Antonucci
  • R H Tukey
  • C M Eng

Detail Information

Publications39

  1. doi The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells
    Naonobu Fujita
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Japan
    FEBS J 275:788-98. 2008
    ..by hexokinase, whereas fructose 6-phosphate from glucose is converted to mannose 6-phosphate by phosphomannose isomerase (PMI). Normally, PMI provides the majority of mannose for glycan synthesis...
  2. pmc Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice
    Vandana Sharma
    2Sanford Burnham Medical Research Institute SBMRI, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    FASEB J 28:1854-69. 2014
    Patients with congenital disorder of glycosylation (CDG), type Ib (MPI-CDG or CDG-Ib) have mutations in phosphomannose isomerase (MPI) that impair glycosylation and lead to stunted growth, liver dysfunction, coagulopathy, hypoglycemia, ..
  3. pmc Metabolically programmed quality control system for dolichol-linked oligosaccharides
    Yoichiro Harada
    Glycometabolome Team, Systems Glycobiology Research Group and Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN Max Planck Joint Research Center, Global Research Cluster, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 110:19366-71. 2013
    ..We propose that this degradation system may avoid abnormal N-glycosylation with premature oligosaccharides under conditions that impair efficient DLO biosynthesis. ..
  4. pmc Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9
    R H Tukey
    Proc Natl Acad Sci U S A 81:3163-6. 1984
    ..Chromosome segregation analysis of 12 hybrid clones demonstrated that the structural genes for both P1-450 and P3-450 can be assigned to mouse chromosome 9...
  5. pmc Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains
    C A Kozak
    J Exp Med 155:524-34. 1982
    ..These studies provide further evidence that endogenous ecotropic V loci are present at different chromosomal sites in unrelated mouse strains and emphasize the role of germ line reinfections in the generation of this diversity...
  6. ncbi [Presence of a male sterility factor, Hst-2, segregating in interspecies crosses. M. musculus L. x M. spretus Lastaste and linked to Mod-1, and Mpi-1 on chromosome 9]
    F Bonhomme
    C R Seances Acad Sci III 294:691-3. 1982
    ..The sterility depends on several independant genetic factors. Using a linkage analysis carried out with biochemical markers, we have been able to localize one of these designated Hst-2, close to Mod-1 on chromosome 9...
  7. ncbi Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 21:37-48. 1983
    ..1.1.6). ES-17 was shown to be controlled by the structural locus Es-17, located on chromosome 9. From test-cross data, a gene order of Es-17-8.7 +/- 2.5 map units-Mpi-1-10.2 +/- 2.7 map units-Mod-1 was established.
  8. pmc Application of the ovarian teratoma mapping method in the mouse
    J T Eppig
    Genetics 103:797-812. 1983
    ..the accuracy of the ovarian teratoma mapping method, we compared the recombination frequency obtained for the Mpi-1-Mod-1 interval on chromosome 9 using the ovarian teratoma method to that obtained using a standard backcross...
  9. ncbi A serum protein polymorphism determinant on chromosome 9 of Mus musculus
    E M Eicher
    Mol Gen Genet 177:571-6. 1980
    ..The new serum protein locus, gene symbol Sep-1, has been located on Chromosome 9, gene order Lap-1--Sep-1--Mpi-1--d--Mod-1, by utilizing information obtained from 52 recombinant inbred strains together with standard genetic ..
  10. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed...
  11. ncbi Linkage of the structural gene for uroporphyrinogen I synthase to markers on mouse chromosome 9 in a cross between feral and inbred mice
    T K Antonucci
    Biochem Genet 20:703-10. 1982
    ..The observed gene order is centromere-Ups-15-Mpi-1-22-Mod-1. Ups is unlinked to Lv, which encodes the previous enzyme in the heme biosynthesis pathway...
  12. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  13. ncbi Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids
    R Schafer
    Somatic Cell Genet 6:709-17. 1980
    ..The appearance of a heteropolymeric band in hybrid cells expressing mouse GOT-1 suggests that this enzyme molecule is probably composed of two subunits...
  14. ncbi The serotonin 5-HT1B receptor subtype (Htr1b) gene maps to mouse chromosome 9
    D Simon-Chazottes
    Unite de Genetique des Mammiferes, URA 361, Institut Pasteur, Paris, France
    Mamm Genome 4:397-8. 1993
  15. ncbi Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization
    L Yan
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, MN 55905, USA
    DNA Cell Biol 17:659-67. 1998
    ..Cloning and structural characterization of the mouse Nnmt gene will make it possible to study molecular genetic mechanisms involved in the expression of this important methyltransferase...
  16. ncbi Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase
    Joseph A Davis
    Glycobiology Program, The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Glycobiology 12:435-42. 2002
    b>Phosphomannose isomerase (PMI) interconverts fructose-6-P (Fru-6-P) and mannose-6-P (Man-6-P), linking energy metabolism to protein glycosylation...
  17. ncbi Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality
    Charles DeRossi
    Glycobiology and Carbohydrate Chemistry Program, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 281:5916-27. 2006
    MPI encodes phosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate biosynthesis...
  18. pmc A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
    Amanda H McDaniel
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1078-92. 2006
    ..interval with functional significance to the body fatness phenotype (Il18, Acat1, Cyp19a1, Crabp1, Man2c1, Neil1, Mpi1, Csk, Lsm16, Adpgk, Bbs4, Hexa, Thsd4, Dpp8, Anxa2, and Lipc)...
  19. doi Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9
    Maria Liljander
    Lund Transgenic Core Facility, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Genet Res (Camb) 91:259-65. 2009
    ..Genes of the cytochrome P450 family (1, 11 and 19), such as Cyp19a1, are assumed to be particularly interesting, since they are known to exhibit female-associated reproductive phenotypes, affecting the ovulation rate, if mutated...
  20. doi Ontogeny of D-mannose transport and metabolism in rat small intestine
    Mecedes Cano
    Departamento de Fisiologia y Zoologia, Universidad de Sevilla, Spain
    J Membr Biol 235:101-8. 2010
    Oral mannose therapy is used to treat congenital disorders of glycosylation caused by a deficiency in phosphomannose isomerase. The segmental distribution and ontogenic regulation of D-mannose transport, phosphomannose isomerase, and ..
  21. ncbi Characterization of Int-5, a locus associated with early events in mammary carcinogenesis
    V L Morris
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    Oncogene Res 6:53-63. 1991
    ..3 and 4.0 Kb. These data are consistent with the hypothesis that Int-5 contains an oncogene, different from any other previously described, involved in early events in some models of chemical carcinogenesis...
  22. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  23. ncbi Location of the gene for theta antigen in the mouse. III. The position of Thy-1 relative to Lap-1 and Mpi-1
    T C Douglas
    J Hered 70:250-4. 1979
    ..chromosome 9 of the mouse was determined relative to the biochemical markers Lap-1 (leucine arylaminopeptidase) and Mpi-1 (mannosephosphate isomerase)...
  24. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  25. ncbi The genes coding for pyruvate kinase (M2) and mannosephosphate isomerase are linked in man and mouse
    P A Lalley
    Cytogenet Cell Genet 22:581-4. 1978
  26. ncbi Identification and genetic monitoring of mouse inbred strains using biochemical polymorphisms
    A Groen
    Lab Anim 11:209-14. 1977
    ..examined at 12 chromosome loci coding body protein-polymorphism Es-1, Es-2, Es-3, Es-5, Gpi-1, Hbb, Id-1, Ldr-1, Mpi-1, Mup-1, Pgm-1, Trf). The allelic variation at 7 loci could be detected simultaneously...
  27. ncbi Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome
    C Kozak
    Somatic Cell Genet 1:371-82. 1975
    ..Malate oxidoreductase decarboxylating (MOD) and mannose phosphate isomerase (MPI) segregated concordantly, confirming an established linkage relationship; adenine phosphoribosyltransferase (APRT) ..
  28. ncbi Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Ibaraki, Japan
    Mamm Genome 3:656-8. 1992
  29. ncbi Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9
    C M Ballantyne
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030
    Genomics 9:547-50. 1991
    ..The mapping of Icam-1 to the region known to contain the Idd-2 gene raises the question of whether the phenotypic differences attributed to the Idd-2 locus might be due to genetic variation in Icam-1...
  30. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
    ..mapped by sexual genetics: Dip-1 and Id-1 to chromosome 1; Pgm-2 and Pgd to 4; Pgm-1 to 5; Gpi-1 to 7; Gr-1 to 8; Mpi-1 and Mod-1 to 9; Np-1 and Es-10 to 14...
  31. ncbi Tg (9 HSA-MYC), a homozygous lethal insertion in the mouse
    S Tutois
    Unite de Genetique des Mammiferes, Institut Pasteur, Paris, France
    Mamm Genome 1:184-90. 1991
    ..The 3' flanking sequence has been cloned and analyzed. It contains a unique sequence that has been conserved during evolution and maps to Chromosome (Chr) 9. This mutant has been designated Tg 9 (HSA-MYC)...
  32. pmc Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas
    D Bergeron
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Virol 65:7-15. 1991
    ....
  33. ncbi Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse
    C M Eng
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Genomics 9:278-82. 1991
    ..Using interspecies crosses in mice, the Acra-5 gene was found closely linked to the Mpi-1 locus...
  34. ncbi Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor
    A Bessis
    UA CNRS D1284, Departement des Biotechnologies, Institut Pasteur, Paris, France
    FEBS Lett 264:48-52. 1990
    ..14, 9 and 3 respectively. Moreover, the alpha 4 subunit gene is located on chromosome 2 but is not genetically linked to the alpha 1 subunit gene...
  35. ncbi Linkage of the mouse LDL receptor gene on chromosome 9
    S L Frank
    Department of Microbiology, University of California, Los Angeles 90024
    Genomics 5:646-8. 1989
    ..8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute...
  36. ncbi Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes
    H Satoh
    Cytogenet Cell Genet 39:285-91. 1985
    ..The locations of the following loci were confirmed: ESD, NP, and PEPB on chromosome 1, ME1 and MPI on chromosome 4, AK1 on chromosome 6, and GPI and PEPD on chromosome 9...
  37. ncbi Polymorphism and linkage for mannosephosphate isomerase in Mus musculus
    E A Nichols
    Biochem Genet 8:47-53. 1973
  38. ncbi Genetic mapping of the murine gene and 14 related sequences encoding chromosomal protein HMG-14
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 3:625-32. 1992
    ..Thus, the Hmg14 multigene family is well suited to serve as genetic markers for other linkage studies in mice...
  39. ncbi A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:221-32. 1989
    ..Ways of further improving the MEV stock are discussed. The location of the Myb proto-oncogene is defined relative to Sl and one of the C58/J proviruses on chromosome 10...