Genomes and Genes
Gene Symbol: Mnx1
Description: motor neuron and pancreas homeobox 1
Alias: HB9, Hlxb9, MNR2, motor neuron and pancreas homeobox protein 1, homeobox gene HB9, homeobox protein HB9
Publications120 found, 100 shown here
- Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cordMichiya Sugimori
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
Development 134:1617-29. 2007..We propose a molecular code model whereby the combinatorial actions of two classes of transcription factors coordinately regulate the domain-specific temporal sequence of neurogenesis and gliogenesis in the developing spinal cord...
- ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neuronsS Arber
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Cell 101:485-98. 2000..ER81 therefore controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord...
- THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in ciliaPamela V Tran
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Genet 40:403-10. 2008..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
- Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loopJun An Chen
Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
Neuron 69:721-35. 2011....
- Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrainJohn Jacob
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 136:2477-85. 2009..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
- Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patternsCorinna Haupt
Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Munich Neuherberg, Germany
Eur J Neurosci 31:1164-72. 2010..Thus, Sema3A-Npn-1 signaling plays an important role in the guidance and fasciculation of motor and sensory axons but does not contribute to the developmental elimination of these neurons...
- Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain geneJ T Eggenschwiler
Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
Dev Biol 227:648-60. 2000..The data indicate that opb(+) could act as either a novel component of a dorsalizing pathway or a novel intracellular negative regulator of the Shh signal transduction pathway...
- The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascadePatrick Jacquemin
Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
Dev Biol 258:105-16. 2003..Together with the known role of HNF-6 in pancreatic endocrine cell differentiation, our data point to HNF-6 as a key regulator of pancreas development...
- Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1Juhee Jeong
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 132:143-54. 2005..Furthermore, this feedback mechanism is crucial in generating a neural tube that contains appropriate numbers of all ventral and intermediate neuronal cell types...
- The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cellsShelley B Nelson
Department of Developmental and Cell Biology, University of California at Irvine, 4203 McGaugh Hall, Irvine, CA 92697 2300, USA
Development 134:2491-500. 2007..2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities and implies that both Nkx6.1 and Nkx6.2 possess alpha- and beta-cell-specifying activities...
- Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identityS Arber
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Neuron 23:659-74. 1999The homeobox gene Hb9, like its close relative MNR2, is expressed selectively by motor neurons (MNs) in the developing vertebrate CNS...
- Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9J Thaler
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Neuron 23:675-87. 1999..This pattern resembles a composite of the avian homologs MNR2 and HB9...
- Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervationX Yang
Molecular Neurobiology Program, Skirball Institute, New York University Medical School, New York, NY 10011, USA
Neuron 30:399-410. 2001..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation...
- Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connectionQ Richard Lu
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cell 109:75-86. 2002..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
- The Sox9 transcription factor determines glial fate choice in the developing spinal cordC Claus Stolt
Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
Genes Dev 17:1677-89. 2003....
- A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axonsIvo Lieberam
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
Neuron 47:667-79. 2005..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons...
- V1 spinal neurons regulate the speed of vertebrate locomotor outputsSimon Gosgnach
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 440:215-9. 2006....
- SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein functionC Claus Stolt
Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
Dev Cell 11:697-709. 2006..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
- MuSK controls where motor axons grow and form synapsesNatalie Kim
Molecular Neurobiology Program, The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, NY 10016, USA
Nat Neurosci 11:19-27. 2008....
- Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4Salvatore Cortellino
Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Dev Biol 325:225-37. 2009..We conclude that complex A and complex B factors play similar but distinct roles in ciliogenesis and Shh/Gli3 signaling...
- A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signalingScott D Weatherbee
Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
Hum Mol Genet 18:4565-75. 2009..Thus the disruption of Hh signaling can explain many, but not all, of the defects caused by loss of Mks1...
- ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneuronsAki Itoh
Department of Neurology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
J Neurosci 31:7223-8. 2011..Nuclear HB9/MNX1-positive motoneuron pools were generated similarly in the spinal cord of both ZPK/DLK-deficient and wild-type ..
- Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulationNicolas F Berbari
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Dev Biol 360:66-76. 2011....
- LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neuronsK Sharma
Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA
Cell 95:817-28. 1998..Thus, Lhx3 and Lhx4 act in a binary fashion during a brief period in development to specify the trajectory of motor axons from the neural tube...
- Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9H Li
Department of Microbiology, University of Umea, S 901 87 Umea, Sweden
Nat Genet 23:67-70. 1999..The initial stages of pancreatic development, however, still occur in Pdx1-deficient mice. Hlxb9 (encoding Hb9; ref...
- Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient miceK A Harrison
Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 23:71-5. 1999..The homeobox gene HLXB9 (encoding HB9) is prominently expressed in adult human pancreas, although its role in pancreas development and ..
- Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapseW Lin
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 410:1057-64. 2001..In contrast, the subsequent stages of synaptic growth and maintenance require nerve-derived agrin, and a second nerve-derived signal that disperses ectopic postsynaptic apparatus...
- Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathwayJ T Eggenschwiler
Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Nature 412:194-8. 2001..The data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells...
- Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cordR Scardigli
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 163, 67404 Illkirch Cedex, C U, de Strasbourg, France
Neuron 31:203-17. 2001..Thus, neuronal differentiation involves crossregulatory interactions between a bHLH-driven program of neurogenesis and genetic pathways specifying progenitor and neuronal identity in the spinal cord...
- A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cordMark Wijgerde
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 16:2849-64. 2002..Thus, Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities...
- Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activityMadelen Persson
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
Genes Dev 16:2865-78. 2002..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube...
- Hedgehog signalling in the mouse requires intraflagellar transport proteinsDanwei Huangfu
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
Nature 426:83-7. 2003..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
- All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3C Brian Bai
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Dev Cell 6:103-15. 2004..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
- Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrainAnna Vallstedt
Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
Neuron 45:55-67. 2005..Based on these findings, we propose that oligodendrocytes derive from several distinct positional origins and that the activation of Olig1/2 at different positions is controlled by distinct genetic programs...
- Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cellsSoo Kyung Lee
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Genes Dev 19:282-94. 2005....
- Lack of TCF2/vHNF1 in mice leads to pancreas agenesisC Haumaitre
Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
Proc Natl Acad Sci U S A 102:1490-5. 2005..At earlier stages, only a dorsal bud rudiment forms transiently and expresses the transcription factors Ipf1 and Hlxb9 but lacks the key transcription factor involved in the acquisition of a pancreatic fate, Ptf1a, as well as all ..
- A developmental switch in the response of DRG neurons to ETS transcription factor signalingSimon Hippenmeyer
Biozentrum, Department of Cell Biology, University of Basel, Switzerland
PLoS Biol 3:e159. 2005..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation...
- Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanismWeichun Lin
The Salk Institute, La Jolla, California 92037, USA
Neuron 46:569-79. 2005..Genetic elimination of Cdk5 or blocking ACh production prevents the dispersion of AChR clusters in agrin mutants. Therefore, we propose that ACh negatively regulates neuromuscular synapse formation through a Cdk5-dependent mechanism...
- Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain proteinJennifer M Wilson
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
J Neurosci 25:5710-9. 2005..in which expression of green fluorescent protein is driven by the promoter for the homeodomain transcription factor Hb9, as well as Hb9-lacZ knock-in mice, we describe a novel population of glutamatergic interneurons located adjacent ..
- Cilia and Hedgehog responsiveness in the mouseDanwei Huangfu
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:11325-30. 2005....
- Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-Tooth type 4B1 neuropathy with myelin outfoldingsAnnalisa Bolis
Dulbecco Telethon Institute, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 25:8567-77. 2005..Thus, therapeutical approaches might be designed in the future to specifically deliver the Mtmr2 phospholipid phosphatase to Schwann cells in affected nerves...
- HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant IronsideBasile Tarchini
National Research Centre Frontiers in Genetics and Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
Genes Dev 19:2862-76. 2005..These results highlight the importance of a systematic approach when studying such clustered gene families, and give insights into the function and regulation of Hox and Evx2 genes during early spinal cord development...
- Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteinsJonathan T Eggenschwiler
Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
Dev Biol 290:1-12. 2006..Instead, Rab23 appears to regulate subcellular localization of essential components of the Hedgehog pathway that act downstream of Smoothened and upstream of Gli proteins...
- Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cellsNoritaka Masahira
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
Dev Biol 293:358-69. 2006..These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain...
- CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmissionMarko Jevsek
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, NY 10016, USA
Proc Natl Acad Sci U S A 103:6374-9. 2006..Because CD24 is also expressed in some neurons, additional experiments will be required to determine whether pre- or postsynaptic CD24 mediates these effects on presynaptic development and function...
- T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migrationMi Ryoung Song
Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Development 133:4945-55. 2006..Our study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway...
- Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cordChian Yu Peng
Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA
Neuron 53:813-27. 2007..Thus, our study provides insight into the cell-extrinsic signaling that controls combinatorial transcription factor profiles involved in regulating the process of interneuron subtype diversification...
- The graded response to Sonic Hedgehog depends on cilia architectureTamara Caspary
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Dev Cell 12:767-78. 2007..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
- Lateral motor column axons execute a ternary trajectory choice between limb and body tissuesVictor Luria
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Neural Dev 2:13. 2007..The cellular logic that guides motor axon trajectory choices into non-limb tissues such as the ventral flank remains unclear...
- Heterogeneous electrotonic coupling and synchronization of rhythmic bursting activity in mouse Hb9 interneuronsJ M Wilson
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada
J Neurophysiol 98:2370-81. 2007..b>Hb9 interneurons, a small population of discretely localized interneurons in the mouse spinal cord, are conditionally ..
- Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneuronsYuanyuan Wu
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Development 135:171-82. 2008..Together, these results show that Hoxc10 and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity...
- Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activityNatalia V De Marco Garcia
Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Neuron 57:217-31. 2008..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity...
- Retrograde regulation of motoneuron differentiation by muscle beta-cateninXiao Ming Li
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
Nat Neurosci 11:262-8. 2008..Taken together, these observations indicate a role for muscle beta-catenin in presynaptic differentiation and function, identifying a previously unknown retrograde signaling in the synapse formation and synaptic plasticity...
- Regulation of motor neuron specification by phosphorylation of neurogenin 2Yong Chao Ma
F M Kirby Neurobiology Center, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Neuron 58:65-77. 2008....
- Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limbVictor Luria
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
Neuron 60:1039-53. 2008..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program...
- Motor neurons with axial muscle projections specified by Wnt4/5 signalingDritan Agalliu
Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Neuron 61:708-20. 2009..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
- HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interactionFeng Ye
Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, USA
Nat Neurosci 12:829-38. 2009..Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation...
- Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron developmentC Francius
Universite Catholique de Louvain, Institute of Neuroscience, Brussels, Belgium
Neuroscience 165:116-29. 2010..Together, our data unveil a complex and dynamic expression profile of the OC proteins in spinal MN, which suggests that these factors may participate in regulatory networks that control different steps of motor neuron development...
- Neural cell adhesion molecule is required for stability of reinnervated neuromuscular junctionsPeter H Chipman
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
Eur J Neurosci 31:238-49. 2010..Consideration is given to the role of NCAM in terminal Schwann cells for maintaining synaptic integrity and how NCAM dysfunction may contribute to motoneuron disorders...
- MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cordKang Zheng
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
J Neurosci 30:8245-50. 2010..By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue...
- Complex interactions between genes controlling trafficking in primary ciliaPolloneal Jymmiel R Ocbina
Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA
Nat Genet 43:547-53. 2011....
- Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor programFloor J Stam
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
Development 139:179-90. 2012....
- RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factorsNancy Thompson
Swiss Institute for Experimental Cancer Researcha and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
Mol Cell Biol 32:1189-99. 2012..We demonstrate that Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of PTF1a and is regulated by ..
- Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunctionRocky G Gogliotti
Human Molecular Genetics Program, Children s Memorial Research Center, Chicago, Illinois 60614, USA
J Neurosci 32:3818-29. 2012..Using an Hb9-Cre allele, we increased Smn levels autonomously within MNs and demonstrate that MN rescue significantly improves ..
- Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formationHaitao Wu
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
Neuron 75:94-107. 2012..These observations uncovered distinct roles of LRP4 in motoneurons and muscles in NMJ development...
- Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cellsMichael Horn
Department of Biology, Institute of Molecular Health Sciences, Cell Biology, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland
Brain 135:3567-83. 2012....
- Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferentsTushar D Patel
Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
Neuron 38:403-16. 2003..Finally, addition of NT3 to DRG explant cultures resulted in induction of ER81 protein. Our data indicate that NT3 mediates the formation of proprioceptive afferent-motor neuron connections via regulation of ER81...
- Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signallingJ Briscoe
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Nature 398:622-7. 1999..Thus, Nkx2.2 has an essential role in interpreting graded Shh signals and selecting neuronal identity...
- GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron poolsGeorg Haase
INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, Marseille, France
Neuron 35:893-905. 2002..Thus, GDNF acts as a peripheral signal to induce PEA3 expression in specific motor neuron pools thereby regulating both cell body position and muscle innervation...
- Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit pointsMatthieu Vermeren
MRC Centre for Developmental Neurobiology, Guy s Campus, King s College London, SE1 1UL, London, United Kingdom
Neuron 37:403-15. 2003..Thus, before the formation of a mature transitional zone at the MEP, BC cells maintain a cell-tight boundary that allows motor axons to cross but blocks neuron migration...
- Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limbEdgar R Kramer
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
Neuron 50:35-47. 2006..This phenotype is enhanced in mutant mice lacking Ret and EphA4. Thus, Ret and EphA4 signals cooperate to enforce the precision of the same binary choice in motor-axon guidance...
- Ftm is a novel basal body protein of cilia involved in Shh signallingJeanette Vierkotten
Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
Development 134:2569-77. 2007..Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways...
- A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant miceR M Clark
Department of Developmental Biology, Stanford University, California 94305 5327, USA
Genomics 67:19-27. 2000..The human ortholog of Lmbr1 maps within the recently described interval for human PPD, strengthening the possibility that both mouse and human limb abnormalities are due to defects in the same highly conserved gene...
- Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrainAlexandre Pattyn
Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
Development 130:4149-59. 2003..Thus, both visceral and somatic motoneuron differentiation appear to rely on the combined activity of cell intrinsic determinants, rather than on a single key determinant of neuronal cell fate...
- Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cordQiubo Lei
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Development 131:3593-604. 2004..Thus, multiple ventral neuronal types can develop in the absence of Gli function, but require balanced Gli protein activities for their correct patterning and differentiation...
- Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterningKatrin Götz
Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, Dusseldorf, Germany
Dev Dyn 233:623-30. 2005....
- Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cordShengguo Li
Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 102:10688-93. 2005..However, coexpression of both Foxn4 and Mash1 promotes the V2b fate while inhibiting the V2a fate, indicating that Foxn4 cooperates with Mash1 to specify the identity of V2b neurons from bipotential p2 progenitors...
- ETS transcription factor Erm controls subsynaptic gene expression in skeletal musclesSimon Hippenmeyer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Neuron 55:726-40. 2007..Together, our findings define Erm as an upstream regulator of a transcriptional program selective to subsynaptic nuclei at the NMJ and underscore the importance of transcriptional control of local synaptic protein accumulation...
- The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypesThomas W Gould
Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
J Neurosci 28:2131-46. 2008..Therefore, although GDNF influences several aspects of MN development, the survival-promoting effects of GDNF during programmed cell death are mostly confined to spindle-innervating MNs...
- GluR1 controls dendrite growth through its binding partner, SAP97Weiguo Zhou
Department of Pediatrics, Division of Neurology, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:10220-33. 2008..Our findings suggest that the C-terminal 7 aa of GluR1 are essential for bringing SAP97 to the plasma membrane, where it acts to translate the activity of AMPA receptors into dendrite growth...
- Tulp3 is a critical repressor of mouse hedgehog signalingDon A Cameron
Department of Biochemistry, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
Dev Dyn 238:1140-9. 2009..This work uncovers a novel role for Tulp3 as a negative regulatory factor in the Hh pathway...
- Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transductionHyuk Wan Ko
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Dev Cell 18:237-47. 2010..We propose that Bromi and CCRK control the structure of the primary cilium by coordinating assembly of the axoneme and ciliary membrane, allowing Gli proteins to be properly activated in response to Shh signaling...
- Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in miceYibo Qu
Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, Brussels, Belgium
J Neurosci 30:9392-401. 2010..These data indicate that Celsr1-3 differentially regulate FBM neuron migration. Celsr1 helps to specify the direction of FBM neuron migration, whereas Celsr2 and 3 control its ability to migrate...
- Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tubeAlisa S W Shum
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
Dev Dyn 239:3192-203. 2010..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
- Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signalingVanessa L Horner
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Dev Biol 355:43-54. 2011..We demonstrate that Arl13b is required non-autonomously for BMP signaling and Wnt ligand expression, indicating that the abnormal Shh signaling environment in Arl13b(hnn) embryos indirectly causes dorsal defects...
- TACE (ADAM17) inhibits Schwann cell myelinationRosa La Marca
Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
Nat Neurosci 14:857-65. 2011..Thus, TACE is a modulator of NRG1 type III activity and is a negative regulator of myelination in the PNS...
- Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell culturesMegumi Hirose
Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7332, USA
J Neurosci Res 89:1363-74. 2011..mice by immunofluorescence, on the other hand, revealed no obvious alterations in expressions of Islet1/2, MNR2, Lim1/2, Nkx2.2, or Shh, although the Pax6-positive area was slightly expanded in PACAP-deficient spinal cord...
- Dorsal pancreas agenesis in N-cadherin- deficient miceF Esni
Department of Medical Biochemistry, Box 440, Goteborg University, Goteborg, S 405 30, Sweden
Dev Biol 238:202-12. 2001..Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme...
- Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic developmentH Li
Umeå Center for Molecular Medicine, Umea University, Umea, SE 901 87, Sweden
Dev Biol 240:247-53. 2001The homebox gene Hlxb9, encoding Hb9, exhibits a dual expression profile during pancreatic development...
- Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneuronsGary O Gaufo
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Development 130:5191-201. 2003....
- Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulationRuth Simon
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Mol Cell Biol 23:9046-60. 2003..Intriguingly, our studies also demonstrated a striking autoregulation of the Sax2 gene in both positive- and negative-feedback mechanisms depending on the specific cell type expressing Sax2...
- The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiationJunfeng Wang
Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Dev Biol 266:178-89. 2004..for appropriate initiation of beta-cell differentiation because loss of Pax4 prevents the expression of Pdx1, HB9 and insulin in beta-cell precursors...
- GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regenerationHideki Enomoto
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 44:623-36. 2004..Thus RET-independent GFRalpha1 is dispensable for organogenesis and nerve regeneration in vivo, indicating that trans-signaling and GFRalpha-dependent NCAM signaling play a minor role physiologically...
- Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neuronsTakahiro Nakano
Department of Neurology and Neuroscience, Cornell University Medical Center, New York, NY 10021, USA
Dev Biol 283:474-85. 2005The homeobox gene Hb9 is expressed selectively by motor neurons (MNs) in the developing CNS. Previous studies have identified a 9-kb 5' fragment of the mouse Hb9 gene that is sufficient to direct gene expression to spinal MNs in vivo...
- Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalusMark Merchant
Department of Molecular Biology, South San Francisco, CA 94080, USA
Mol Cell Biol 25:7054-68. 2005..These results show that the mFu homologue is not required for Hh signaling during embryonic development but is required for proper postnatal development, possibly by regulating the CSF homeostasis or ciliary function...
- Generation of cerebellar neuron precursors from embryonic stem cellsHong Lin Su
Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo, Kobe 650 0047, Japan
Dev Biol 290:287-96. 2006..This is the first report of in vitro recapitulation of early differentiation of cerebellar neurons by using the ES cell system...
- Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivoSen Wu
Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah 84112, USA
Development 133:581-90. 2006..The data presented herein supports a sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in vivo from neuroepithelial stem cells, but do not share a common lineage-restricted progenitor...
- Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- miceAmir Asayesh
Umeå Centre for Molecular Medicine, Umea University, S 901 87, Umea, Sweden
Genes Dev 20:2208-13. 2006....
- An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene BaxAdam K Winseck
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, One Medical Center Boulevard, Winston Salem, NC 27157, USA
Eur J Neurosci 24:2105-17. 2006....
- Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cordBen Liu
The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Dev Dyn 236:829-35. 2007..At late stages of development, Bhlhb5 expression is detected in a subset of late-born dorsal association interneurons that migrate into the uppermost layer of the dorsal horn...
- An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organsJonas Ahnfelt-Rønne
Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
J Histochem Cytochem 55:925-30. 2007..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
- GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELLMark Magnuson; Fiscal Year: 2005..In Aim 3 we will determine the role of alternate RNA processing the insulin receptor in modulating both GK gene transcription and subcellular localization in the pancreatic beta cell. ..
- INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENTAmi Okada; Fiscal Year: 2004..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..