Mmp9

Summary

Gene Symbol: Mmp9
Description: matrix metallopeptidase 9
Alias: AW743869, B/MMP9, Clg4b, Gel B, MMP-9, pro-MMP-9, matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, 92kD gelatinase, 92kD type IV collagenase, collagenase type IVB, gelatinase B
Species: mouse

Top Publications

  1. pmc Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome
    K L Andrews
    Renal Division and the Division of Pulmonary and Critical Care Medicine, The Department of Internal Medicine, The Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Pathol 157:303-11. 2000
  2. pmc Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation
    Kendra J Greenlee
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 177:7312-21. 2006
  3. ncbi Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification
    Sanchita Basu
    Bose Institute, Department of Chemistry, 93 1 Acharya Prafulla Chandra Road, Kolkata 700 009, India
    Cell Microbiol 9:2804-16. 2007
  4. pmc Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
    Vanja Nagy
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 26:1923-34. 2006
  5. pmc Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines
    Basam Z Barkho
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Stem Cells 26:3139-49. 2008
  6. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
  7. ncbi Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury
    Aesim Cho
    Department of Pathology, University of Washington, Seattle 98026, USA
    Circ Res 91:845-51. 2002
  8. ncbi Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan
    Peter H Larsen
    Neuroscience Research Group and the Department of Oncology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 23:11127-35. 2003
  9. pmc Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    A Ducharme
    Cardiovascular Division, Department of Medicine, and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:55-62. 2000
  10. ncbi Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling
    Zorina S Galis
    Division of Cardiology, Dept of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 91:852-9. 2002

Research Grants

  1. Migration of Mature and Immature Dendritic Cells
    HENDRIK VAN DEVENTER; Fiscal Year: 2006
  2. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
  3. Regulation of Signaling in Osteoclast Bone Resorption
    Meenakshi Chellaiah; Fiscal Year: 2007
  4. Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Michael J Stern; Fiscal Year: 2010
  5. Proteases in IOP-mediated glaucomatous damage
    Shravan K Chintala; Fiscal Year: 2010
  6. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
  7. Novel Roles for ADAM15 in Acute Lung Injury
    Caroline A Owen; Fiscal Year: 2010
  8. Viral-induced T Cell Responses in COPD Exacerbation
    Farrah Kheradmand; Fiscal Year: 2009
  9. Role of cockroach proteases in airway inflammation
    Kristen Page; Fiscal Year: 2009
  10. Vascular Mechanisms of Cerebral Ischemic Tolerance
    JEFFREY GIDDAY; Fiscal Year: 2008

Detail Information

Publications178 found, 100 shown here

  1. pmc Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome
    K L Andrews
    Renal Division and the Division of Pulmonary and Critical Care Medicine, The Department of Internal Medicine, The Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Pathol 157:303-11. 2000
    ..b>Gelatinase B (gelB; also known as MMP-9) is expressed in the kidney and is hypothesized to be involved in basement membrane ..
  2. pmc Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation
    Kendra J Greenlee
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 177:7312-21. 2006
    ..MMP2- and MMP9-dependent cleavage of individual Th2 chemokines modulated their chemotactic activity; however, the net effect of ..
  3. ncbi Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification
    Sanchita Basu
    Bose Institute, Department of Chemistry, 93 1 Acharya Prafulla Chandra Road, Kolkata 700 009, India
    Cell Microbiol 9:2804-16. 2007
    ..avium...
  4. pmc Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
    Vanja Nagy
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 26:1923-34. 2006
    ..Together, these data reveal new functions for MMPs in synaptic and behavioral plasticity...
  5. pmc Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines
    Basam Z Barkho
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Stem Cells 26:3139-49. 2008
    ..Thus, endogenous MMPs expressed by aNPCs are important for mediating their neurogenic response to extrinsic signals...
  6. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool...
  7. ncbi Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury
    Aesim Cho
    Department of Pathology, University of Washington, Seattle 98026, USA
    Circ Res 91:845-51. 2002
    ..Thus, our present data indicate that MMP-9 is critical for the development of arterial lesions by regulating both SMC migration and proliferation...
  8. ncbi Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan
    Peter H Larsen
    Neuroscience Research Group and the Department of Oncology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 23:11127-35. 2003
    ..These results emphasize for the first time that upregulation of MMP activity can be important for facilitating regeneration from some types of CNS injury...
  9. pmc Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    A Ducharme
    Cardiovascular Division, Department of Medicine, and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:55-62. 2000
    ..We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental MI than do sibling wild-type (WT) mice...
  10. ncbi Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling
    Zorina S Galis
    Division of Cardiology, Dept of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 91:852-9. 2002
    ..Our results also establish MMP-9 as an attractive therapeutic target for limiting the effects of pathological arterial remodeling in restenosis and atherosclerosis...
  11. pmc Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions
    B Dubois
    Rega Institute for Medical Research, University of Leuven, B 3000 Leuven, Belgium
    J Clin Invest 104:1507-15. 1999
    ..expression of these factors can promote or affect the course of pathologies, we knocked out the mouse gelatinase B gene by replacing the catalytic and zinc-binding domains with an antisense-oriented neomycin resistance gene...
  12. pmc Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
    Veronique Masson
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    FASEB J 19:234-6. 2005
    ..Our data demonstrate for the first time in an experimental model that MMP-2 and MMP-9 cooperate in promoting the in vivo invasive and angiogenic phenotype of malignant keratinocytes...
  13. pmc Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression
    Alayna E Loiselle
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Box 665, 601 Elmwood Avenue, Rochester, New York 14620, USA
    J Orthop Res 27:833-40. 2009
    ..The murine model of primary tendon repair, described here, provides a novel mechanism to study the tendon healing process, and further enhances the understanding of this process at the molecular, cellular, and biomechanical level...
  14. pmc MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage
    Hideo Kobayashi
    Department of Anesthesiology, University of California, San Diego, CA 92093 0629, USA
    Mol Cell Neurosci 39:619-27. 2008
    ..In conclusion, MMPs mediate the initiation and maintenance of mechanical nociception through Schwann cell-mediated MBP processing and support of neuroinflammation...
  15. pmc Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling
    Sophie Lanone
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 110:463-74. 2002
    ..The also demonstrate that MMPs-9 and -12 play different roles in the generation of IL-13-induced inflammation, with MMP-9 inhibiting neutrophil accumulation and MMP-12 contributing to the accumulation of eosinophils and macrophages...
  16. ncbi Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia
    Seong Ryong Lee
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 24:671-8. 2004
    ..05). These data indicate a potential deleterious role for MMP-9 in the pathogenesis of delayed neuronal damage in the hippocampus after global cerebral ischemia...
  17. pmc Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
    R Pyo
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, Wohl Hospital, St Louis, Missouri 63110, USA
    J Clin Invest 105:1641-9. 2000
    ....
  18. ncbi Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch
    J R Chin
    Department of Anatomy, University of California, San Francisco 94143 0750, USA
    Development 124:1519-30. 1997
    ..in the perichondrium of Meckel's cartilage and mesenchymal areas of embryonic day 13-15 mandibles, whereas gelatinase B, collagenase-3, TIMP-1 and TIMP-2 mRNA were found primarily in the ossifying areas of the mandibles...
  19. pmc Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation
    Anne L Jacob
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:315-28. 2006
    ..These data demonstrate that signaling through FGFR1 in osteoblasts is necessary to maintain the balance between bone formation and remodeling through a direct effect on osteoblast maturation...
  20. pmc Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing
    Evan B Katzel
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Orthop Res 29:684-93. 2011
    ..quantitative PCR, in situ hybridization, and immunohistochemistry showed decreased col3a1 and col1a1 and increased MMP9 gene and protein expression in repaired Smad3(-/-) tendons...
  21. doi Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatonin
    Krishnendu Ganguly
    Department of Physiology, Drug Development Diagnostics and Biotechnology Division, CSIR Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata 700032, India
    Biochimie 94:2687-98. 2012
    ..In summary, oxidative stress is preceded by chronic inflammation that enhances the expression of MMP-9 and -3, while melatonin arrests both of them via reduction of AP-1 activity during protection of ulcer...
  22. pmc Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity
    B Lelongt
    Institut National de la Sante et de la Recherche Medicale, Unite 489, Hôpital Tenon and Université Pierre et Marie Curie Paris 6, 75020 Paris, France
    J Exp Med 193:793-802. 2001
    Matrix metalloproteinase (MMP)9/gelatinase B is increased in various nephropathies. To investigate its role, we used a genetic approach. Adult MMP9-deficient (MMP9(-/)-) mice showed normal renal histology and function at 3 mo...
  23. ncbi Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization
    Chad Johnson
    Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 24:54-60. 2004
    ..We compared the specific contributions of these enzymes to SMC-matrix interactions in vitro and in vivo...
  24. pmc MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing
    Noriko Hattori
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    Am J Pathol 175:533-46. 2009
    ..These data suggest that MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in wound healing, while MMP-9 functions in keratinocyte migration...
  25. pmc MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    T H Vu
    Department of Anatomy, University of California, San Francisco 94143, USA
    Cell 93:411-22. 1998
    Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal pattern of skeletal growth plate vascularization and ossification...
  26. ncbi Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration
    J R Robbins
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, 149 Basic Medical Sciences Building, Albuquerque, New Mexico, 87131, USA
    Dev Biol 212:255-63. 1999
    ....
  27. pmc MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    L M Coussens
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cell 103:481-90. 2000
    The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and invasive cancers of the epidermis in a mouse model of multi-stage tumorigenesis elicited by HPV16 oncogenes...
  28. ncbi Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?
    Gyung W Kim
    Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Neurosci 23:8733-42. 2003
    ..65 +/- 17; p < or = 0.05). We conclude that early expression and activation of MMP-9 by ROS may be involved in early BBB disruption and progressive striatal damage after 3-NP treatment...
  29. doi Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells
    Noritaka Ohga
    Department of Oral Pathology and Biology, Division of Oral Pathological Science, University of Hokkaido, Sapporo, Japan
    Cancer Sci 100:1963-70. 2009
    ..Our study showed that EGCG has selective anti-angiogenic effects on TEC and EPC. It is suggested that EGCG could be a promising angiogenesis inhibitor for cancer therapy...
  30. ncbi Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury
    X Wang
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 20:7037-42. 2000
    ..Here, we show that MMP-9 (gelatinase B; EC.3.4.24.35) contributes to the pathophysiology of traumatic brain injury...
  31. ncbi Expression of the type IV collagenase system during mouse kidney development and tubule segmentation
    B Legallicier
    INSERM U489, Tenon Hospital and St Antoine Medical Faculty, Paris 6 University, Paris, France
    J Am Soc Nephrol 12:2358-69. 2001
    Type IV collagenases matrix metalloproteinase-2 (MMP2) and MMP9 and their related proteins, MT1-MMP, tissue inhibitor of metalloproteinases 1 (TIMP1), TIMP2, and TIMP3, are expressed during kidney morphogenesis and nephrogenesis, but the ..
  32. ncbi Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
    Stefan Lorenzl
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    Neuromolecular Med 5:119-32. 2004
    ..In this study, we investigated the involvement of MMP-9 (gelatinase B) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease using zymography,..
  33. ncbi Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification
    Beth L Viviano
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 282:152-62. 2005
    ..This is the first report of a requirement for heparan sulfate, and specifically Gpc3, in the lineage-specific differentiation of these cell types in vivo...
  34. pmc Matrix metalloproteinase-9 inhibition reduces inflammation and improves motility in murine models of postoperative ileus
    Beverley A Moore
    Johnson and Johnson Pharmaceutical Research Division, Spring House, Pennsylvania, USA
    Gastroenterology 141:1283-92, 1292.e1-4. 2011
    ..We evaluated the role of MMP-9 in POI and investigated whether disruption of MMP-9 or administration of an inhibitor of MMP-9 activity reduced cellular inflammation and bowel dysmotility in rat and mouse models of POI...
  35. ncbi Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis
    C Sahlberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Eur J Oral Sci 107:121-30. 1999
    ..We analyzed by in situ hybridization the expression of gelatinase A (MMP-2) and gelatinase B (MMP-9) as well as Timp-1, -2 and -3 during different stages of mouse tooth development...
  36. ncbi MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity
    Jordi Esparza
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    FASEB J 18:1682-91. 2004
    ..Last, we discuss other possible MMP-2-mediated mechanisms which may contribute to the observed phenotype...
  37. pmc A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 183:3400-8. 2009
    ..This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice...
  38. doi Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Arterioscler Thromb Vasc Biol 31:e35-44. 2011
    ..We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro...
  39. pmc MMP2-9 cleavage of dystroglycan alters the size and molecular composition of Schwann cell domains
    Felipe A Court
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 31:12208-17. 2011
    ..Thus, regulated cleavage may be a general mechanism to regulate protein complex composition in physiological conditions, whereas unregulated processing is pathogenic and a target for treatment in disease...
  40. ncbi Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse
    K J Leco
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada
    Dev Genet 21:55-60. 1997
    The activity and expression of matrix metalloproteinase-9/gelatinase B (MMP-9), an enzyme implicated in the implantation process in mice, was investigated in normal and parthenogenetic blastocyst outgrowths...
  41. ncbi Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italia
    Dev Dyn 214:248-58. 1999
    ..On the other hand, gelatinase B transcripts were expressed only by trophoblast giant cells at day 10.5, and were downregulated at later stages...
  42. pmc Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    G Bergers
    Department of Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Cell Biol 2:737-44. 2000
    ..Absence of MMP-2 does not impair induction of angiogenesis, but retards tumour growth, whereas lack of urokinase has no effect. Our results show that MMP-9 is a component of the angiogenic switch...
  43. pmc Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:879-87. 2005
    ..We demonstrate that a Plg cascade synergizes with MMP-9/gelatinase B in vivo during dermal-epidermal separation in an experimental model of bullous pemphigoid (BP), an autoimmune ..
  44. pmc The plasminogen fibrinolytic pathway is required for hematopoietic regeneration
    Beate Heissig
    Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Cell Stem Cell 1:658-70. 2007
    ..Thus, activation of the fibrinolytic cascade is a critical step in regulating the hematopoietic stress response...
  45. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
  46. pmc Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    Alexander T Bauer
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 30:837-48. 2010
    ..Therefore, inhibition of MMP-9 might provide the basis for therapeutic strategies to treat brain edema...
  47. pmc MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix
    Tae Hwa Chun
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:757-67. 2004
    ....
  48. pmc Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage
    Li Tian
    Division of Biochemistry, Department of Biological and Environmental Sciences, Faculty of Biosciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 178:687-700. 2007
    ..Soluble ICAM-5 promotes elongation of dendritic filopodia from wild-type neurons, but not from ICAM-5-deficient neurons. Thus, MMPs are important for ICAM-5-mediated dendritic spine development...
  49. pmc Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis
    Pallavi Garg
    Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 296:G175-84. 2009
    ..Thus inhibition of MMP-9 may be beneficial in treatment of colitis even if resulting in inhibition of MMP-2...
  50. pmc Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation
    Nathalie Ortega
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:3028-39. 2005
    ..Thus, the disruption of growth plate homeostasis in Mmp-9 null mice links galectin-3 and MMP-9 in the regulation of the clearance of late chondrocytes through regulation of their terminal differentiation...
  51. pmc Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 15:467-81. 2001
    ..These results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic argument for a common regulation of osteoblast and chondrocyte differentiation mediated by Cbfa1...
  52. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
  53. pmc Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2
    Farrah Kheradmand
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 115:839-48. 2002
    ..MT1-MMP is, in turn, necessary for activation of MMP-2, a mesenchymal enzyme that is required for normal lung morphogenesis...
  54. ncbi Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis
    Elazar Zelzer
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, MA, USA
    Development 129:1893-904. 2002
    ..We also describe new in vivo evidence for a possible role of VEGF in chondrocyte maturation, and document that VEGF has a direct role in regulating osteoblastic activity based on in vivo evidence and organ culture experiments...
  55. ncbi Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin
    Gudrun Ratzinger
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Immunol 168:4361-71. 2002
    ..These data underscore the importance of MMPs, and they may be of relevance for therapeutically regulating dendritic cell migration in clinical vaccination approaches...
  56. ncbi Role of collagen type II and perlecan in skeletal development
    Erika Gustafsson
    Department of Experimental Pathology, Lund University, 22185 Lund, Sweden
    Ann N Y Acad Sci 995:140-50. 2003
    ..Likewise, intercrossing of perlecan mutants onto an MMP-9-null background could not rescue the ultrastructural abnormalities of the perlecan-deficient cartilage...
  57. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
    ..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth...
  58. pmc Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Clin Invest 118:3012-24. 2008
    ..Thus, targeting the Plg/MMP-9 pathway may be an attractive approach to regulate inflammatory responses and AAA development...
  59. pmc High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development
    P Reponen
    Biocenter, University of Oulu, Finland
    J Cell Biol 124:1091-1102. 1994
    cDNA clones for murine 92 kD type IV collagenase (gelatinase B) were generated for the determination of its primary structure and for analysis of temporal and spatial expression in vivo...
  60. ncbi Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA
    H Tanaka
    Department of Microbiology, Shionogi Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 190:732-40. 1993
    ..Transfection of the cDNA in an expression vector resulted in production of the 105-kDa gelatinase, thus confirming that this cDNA is functional...
  61. ncbi Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation
    C M Alexander
    Laboratory of Radiobiology, Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, USA
    Development 122:1723-36. 1996
    b>Gelatinase B, a matrix metalloproteinase (MMP) of high specific activity, is highly expressed and activated by mouse blastocysts in culture, and inhibition of this enzyme activity inhibits lysis of extracellular matrix (Behrendtsen, O...
  62. pmc Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro
    B Lelongt
    Institut National de la Sante et de la Recherche Medicale, Unité 64, Hopital Tenon, Paris, France
    J Cell Biol 136:1363-73. 1997
    ..microscopy and zymograms of kidney lysates showed that the mesenchyme of embryonic kidneys synthesized both MMP9 and MMP2 enzymes...
  63. pmc Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Exp Med 188:475-82. 1998
    ..b>Gelatinase B is present in BP blister fluid and can cleave BP180...
  64. ncbi Expression of matrix metalloproteinases 2 and 9 in regenerating skeletal muscle: a study in experimentally injured and mdx muscles
    S Kherif
    Developpement, Pathologie, Régénération du Système Neuromusculaire Institut de Myologie, INSERM U 153, Rue du Mur des Fermiers Généraux, 47, Bd de l Hopital, Paris Cedex 13, FR 75651, France
    Dev Biol 205:158-70. 1999
    ....
  65. pmc Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
    Q Yu
    Molecular Pathology Unit and MGH Cancer Center, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129, USA
    Genes Dev 13:35-48. 1999
    ..Our observations indicate that CD44 serves to anchor MMP-9 on the cell surface and define a mechanism for CD44-mediated tumor invasion...
  66. pmc Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response
    M Wang
    Division of Dermatology, Department of Medicine, Barnes Jewish Hospital at Washington University Medical Center, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:6885-9. 1999
    ..We have studied mice with deficiencies of stromelysin-1 (MMP-3) or gelatinase B (MMP-9) in a dinitrofluorobenzene (DNFB)-induced model of contact hypersensitivity (CHS)...
  67. ncbi Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure
    S Heymans
    Center for Transgene Technology, Flanders Interuniversity, Leuven, Belgium
    Nat Med 5:1135-42. 1999
    ....
  68. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
    ..These observations suggest that coordinated CD44, MMP-9, and TGF-beta function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion...
  69. ncbi Occurrence and temporal variation in matrix metalloproteinases and their inhibitors during murine secondary palatal morphogenesis
    J Morris-Wiman
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, USA
    J Craniofac Genet Dev Biol 19:201-12. 1999
    ..The results of this study demonstrate that MMPs 2, 3, 7, 9 and 13 and TIMPs 1 and 2 and their messages are present during the course of palatal shelf remodelling and that their expression is temporally regulated...
  70. pmc Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin
    T Betsuyaku
    Departments of Medicine, Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Pathol 157:525-35. 2000
    Increased expression of matrix metalloproteinases, particularly gelatinase B (MMP-9), has been described in the lungs in pulmonary fibrosis...
  71. ncbi The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
    Z Liu
    Department of Dermatology, University of North Carolina, Chapel Hill 27599, USA
    Cell 102:647-55. 2000
    We have identified the key protein substrate of gelatinase B/MMP-9 (GB) that is cleaved in vivo during dermal-epidermal separation triggered by antibodies to the hemidesmosomal protein BP180 (collagen XVII, BPAG2)...
  72. ncbi Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration
    Royce Mohan
    New England Eye Center, Tufts University School of Medicine, and the Tufts Center for Vision Research, Boston, Massachusetts 02111, USA
    J Biol Chem 277:2065-72. 2002
    We studied the role of the matrix metalloproteinase gelatinase B (gelB; MMP-9) in epithelial regeneration using the gelB-deficient mouse...
  73. ncbi Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, KU Leuven, B 3000, Leuven, Belgium
    Mech Dev 111:61-73. 2002
    ....
  74. pmc Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:859-69. 2002
    ..These data demonstrate that FGF18 signals through another FGFR to regulate osteoblast growth. Signaling to multiple FGFRs positions FGF18 to coordinate chondrogenesis in the growth plate with osteogenesis in cortical and trabecular bone...
  75. pmc Up-regulation of MMP-8 and MMP-9 activity in the BALB/c mouse spinal cord correlates with the severity of experimental autoimmune encephalomyelitis
    P T Nygårdas
    Department of Biochemistry and Pharmacy, Abo Akademi University, Turku, Finland
    Clin Exp Immunol 128:245-54. 2002
    ..The study provides the basis for establishment of MMP-specific therapy in this model...
  76. ncbi Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro
    Jennifer R Allport
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Leukoc Biol 71:821-8. 2002
    ..These results indicate that although neutrophil proteases may play a role in the acute inflammatory response, neutrophil elastase or MMP-9 is not essential for neutrophil transendothelial migration in this murine system...
  77. ncbi S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
    ..These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity...
  78. pmc Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events
    Linda J Noble
    Department of Neurosurgery and Anatomy, University of California at San Francisco, San Francisco, California 94143 0520, USA
    J Neurosci 22:7526-35. 2002
    ..Our findings suggest that early inhibition of MMPs may be an efficacious strategy for the spinal cord-injured patient...
  79. pmc Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
    J Clin Invest 110:625-32. 2002
    ..These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA...
  80. pmc Altered fracture repair in the absence of MMP9
    Celine Colnot
    Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA 94143 0514, USA
    Development 130:4123-33. 2003
    ..Here, we provide the first genetic evidence that matrix metalloproteinase 9 (MMP9) regulates crucial events during adult fracture repair...
  81. ncbi Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development
    Nagako Yoshiba
    Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Dev Dyn 228:105-12. 2003
    ..The distinct temporospatial distribution patterns of the TIMPs suggest that these inhibitors play several intrinsic roles during tooth development...
  82. ncbi MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum
    Catherine Vaillant
    Institut National de la Santé et de la Recherche Médicale U433, Neurobiologie Experimentale et Physiopathologie, Faculte de Medecine Laennec, 69372 Lyon Cedex 08, France
    Mol Cell Neurosci 24:395-408. 2003
    ....
  83. pmc Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines
    David B Corry
    Baylor College of Medicine, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 18:995-7. 2004
    ..Here we show that leukocyte MMP9 is the dominant airway MMP controlling inflammatory cell egression...
  84. ncbi Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis
    H H Lee
    Department of Parasitology, Chung Shan Medical University, 402 Taichung, Taiwan
    Parasitol Res 94:321-8. 2004
    ..When immunoblots were performed using specific antiserums against the 94-kDa gelatinase B (matrix metalloproteinase-9; MMP-9) with cerebrospinal fluid (CSF), the 94-kDa immunopositive band was MMP-9...
  85. pmc Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
    Dominique Stickens
    Department of Anatomy and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143 0452, USA
    Development 131:5883-95. 2004
    ..degradation of cartilage collagen and aggrecan is a coordinated process in which MMP13 works synergistically with MMP9. Mice lacking both MMP13 and MMP9 had severely impaired endochondral bone, characterized by diminished ECM ..
  86. pmc Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
    Masaki Inada
    Center for Immunology and Inflammatory Diseases, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 101:17192-7. 2004
    ..Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development...
  87. ncbi Matrix metalloproteinase-9 in macrophages induces thymic neovascularization following thymocyte apoptosis
    Chikako Odaka
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
    J Immunol 174:846-53. 2005
    ..These studies demonstrate a potential role of macrophage MMP-9 in the remodeling of thymic extracellular matrix following thymocyte apoptosis...
  88. ncbi Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development
    Katia Bourd-Boittin
    Matrices Extracellulaires et Biominéralisation, EA 2496, Faculte de Chirurgie Dentaire, Universite Rene Descartes Paris V, Montrouge, France
    Exp Cell Res 304:493-505. 2005
    ..These findings demonstrate the critical role of MMPs in the processing and maturation of the dental matrix...
  89. ncbi Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas
    Sajani S Lakka
    Departments of Biomedical and Therapeutic Sciences Program of Cancer Biology, College of Medicine, University of Illinois, Peoria, IL 61656, USA
    J Biol Chem 280:21882-92. 2005
    ..Our results provide evidence that the use of hairpin siRNA expression vectors for uPAR and MMP-9 may provide an effective tool for cancer therapy...
  90. ncbi Hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor and erythropoietin in the absence of matrix metalloproteinase-9
    S N Robinson
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    Stem Cells Dev 14:317-28. 2005
    ..These data demonstrate that MMP-9 is not required for EPO + G-CSF mobilization and that alternative mobilization mechanisms must be active at clinically relevant cytokine concentrations...
  91. ncbi A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia
    Zezong Gu
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurosci 25:6401-8. 2005
    ..We conclude that MMP-9 is a highly promising drug target and that SB-3CT derivatives have significant therapeutic potential in stroke patients...
  92. ncbi Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction
    Merry L Lindsey
    Division of Cardiothoracic Surgery Research, Rm 629, Strom Thurmond Research Bldg, 770 MUSC Complex, Medical Univ of South Carolina, 114 Doughty St, PO Box 250778, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 290:H232-9. 2006
    ..Thus targeted strategies to inhibit MMP-9 early post-MI will likely not impair the angiogenic response...
  93. pmc TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
    Veronica I Shubayev
    San Diego VA Healthcare System, CA 92161, USA
    Mol Cell Neurosci 31:407-15. 2006
    ..Finally, local application of MMP-9 on TNFalpha-/- nerves increased macrophage recruitment to the lesion. These data suggest that TNFalpha lies upstream of MMP-9 in the pathway of macrophage recruitment to injured peripheral nerve...
  94. ncbi Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages
    Svetlana Pavlovic
    Department of Pathology and Laboratory Medicine, Vascular Biology Center, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 281:3321-8. 2006
    ..Thus, COX-2-dependent ECM-induced proteinase expression is effectively blocked by selective inhibition of EP4, a member of the PGE2 family of receptors...
  95. ncbi Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP
    Florencia E Castaneda
    Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 129:1991-2008. 2005
    ....
  96. ncbi Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice
    Dae Hyun Lim
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Am J Physiol Lung Cell Mol Physiol 291:L265-71. 2006
    ..e., modest reduction in levels of peribronchial fibrosis) but does not play a significant role in mucus expression, smooth muscle thickness, or airway responsiveness...
  97. pmc Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection
    Jennifer L Taylor
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 74:6135-44. 2006
    ....
  98. pmc Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice
    Alfredo Santana
    Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, Tenerife, Spain
    World J Gastroenterol 12:6464-72. 2006
    ..To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice...
  99. ncbi Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome
    Ada W Y Chung
    Child and Family Research Institute, Department of Pediatrics, British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Circ Res 101:512-22. 2007
    ..The resulting elastic fiber degeneration with deterioration of the aortic contraction and mechanical properties may explain the pathogenesis of TAA...
  100. pmc Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway
    Apurva K Srivastava
    Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, California 92357, USA
    J Biol Chem 282:35113-24. 2007
    ..We conclude that TAK1-mediated pathways are involved in TNF-alpha-induced MMP-9 production in skeletal muscle cells...
  101. pmc Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation
    Hyoung Kyu Yoon
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1557-63. 2007
    ..Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of oxidative lung disorders including acute lung injury, asthma, and chronic obstructive pulmonary disease...

Research Grants27

  1. Migration of Mature and Immature Dendritic Cells
    HENDRIK VAN DEVENTER; Fiscal Year: 2006
    ..All have extensive experience in developing the careers o f young scientists. This work has the support of the Lineberger Comprehensive Cancer Center which has made accessible its core facilities. ..
  2. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
    ..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
  3. Regulation of Signaling in Osteoclast Bone Resorption
    Meenakshi Chellaiah; Fiscal Year: 2007
    ..abstract_text> ..
  4. Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Michael J Stern; Fiscal Year: 2010
    ..We further propose that the severity of this ALKC is worsened by defective self tolerance mechanisms. ..
  5. Proteases in IOP-mediated glaucomatous damage
    Shravan K Chintala; Fiscal Year: 2010
    ..abstract_text> ..
  6. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..by IFN? (MIG, or CXCL9) and strongly up-regulate macrophage elastolytic proteinases, in particular MMP12 and MMP9. T cells isolated in the blood and lungs of current and former smokers recognize neutrophil elastase derived ..
  7. Novel Roles for ADAM15 in Acute Lung Injury
    Caroline A Owen; Fiscal Year: 2010
    ..abstract_text> ..
  8. Viral-induced T Cell Responses in COPD Exacerbation
    Farrah Kheradmand; Fiscal Year: 2009
    ....
  9. Role of cockroach proteases in airway inflammation
    Kristen Page; Fiscal Year: 2009
    ..Finally, we will investigate the role of endogenous TNF alpha in the airways using a TNF alpha neutralizing antibody and TNF alpha knockout mice. ..
  10. Vascular Mechanisms of Cerebral Ischemic Tolerance
    JEFFREY GIDDAY; Fiscal Year: 2008
    ..abstract_text> ..
  11. GENETICALLY TARGETABLE LABELS FOR LIGHT AND EM
    Roger Tsien; Fiscal Year: 2007
    ..These activities benefit from the combination of this applicant teams expertise in chemistry, imaging instrument development, cell and molecular biology, physics and biophysics. ..
  12. The Role of Proteases in Lung Inflammation & Remodeling
    Farrah Kheradmand; Fiscal Year: 2007
    ..This work may serve as the foundation for future therapeutic studies that target a broad range of asthmatic patients. ..
  13. ISCHEMIC PROTECTION OF RETINA BY HYPOXIC PRECONDITIONING
    JEFFREY GIDDAY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  14. Retinal Ischemia-induced MMPs and ganglion cell death
    Shravan Chintala; Fiscal Year: 2004
    ..model in mice, support the hypothesis that retinal ischemia induces expression of matrix metalloproteinase gelatinase B (MMP-9) by cells in the ganglion cell layer; that MMP-9 mediates degradation of extracellular matrix (ECM) ..
  15. EPITHELIAL/MESENCHYMAL INTERACTIONS IN LUNG DEVELOPMENT
    Farrah Kheradmand; Fiscal Year: 2002
    ..Michael Mafthay, Carol Basbaum, and Gerald Cunha, all senior faculty members of Division of Pulmonary and Department of Anatomy at UCSF. (End of Abstract) ..
  16. The Role of Proteinases in Experimental Asthma
    Farrah Kheradmand; Fiscal Year: 2006
    ..of MMPs in allergic lung disease is underscored by our recent reports showing that mice deficient in MMP2, MMP9 or both show enhanced accumulation of lung inflammatory cells and are susceptible to asphyxiation when exposed to ..
  17. ISOLATION OF GENES FOR PAGET DISEASE AND OSTEOSARCOMA
    Robin Leach; Fiscal Year: 2001
    ..Leach's laboratory will use meiotic mapping with numerous Paget disease kindreds. Identification of this gene (or these genes) is an important step towards the development of treatment for osteosarcoma and Paget disease. ..
  18. Novel Roles for MMP-8 in Acute Lung Injury
    Caroline Owen; Fiscal Year: 2008
    ..We anticipate that in the future, our studies will facilitate the development of new treatment strategies that may reduce mortality and morbidity in ALl syndromes. ..
  19. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008
    ..abstract_text> ..
  20. Mast Cell Role in Masseter Muscle Repair
    JOYCE MORRIS WIMAN; Fiscal Year: 2005
    ....
  21. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. MMP-9 in Blood-Brain Barrier Failure in Fulminant Hepatic Failure
    Justin Nguyen; Fiscal Year: 2009
    ..Specific Aim 2: To determine if inhibition of MMP-9 results in an increase in survival in experimentally induced FHF. ..
  23. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  24. MMP-9 mediates cerebral edema in fulminant liver failure
    Justin Nguyen; Fiscal Year: 2004
    ..2. To determine whether cerebral edema is attenuated in MMP-9 knockout mice following experimentally induced FHF. ..
  25. Neuroprotective Mechanisms of Neuroglobin in Stroke
    Xiaoying Wang; Fiscal Year: 2010
    ..These proposed experiments should provide new insight into how Ngb protects neurons from hypoxia/ischemia and may ultimately lead to novel therapeutic strategies for the acute treatment of stroke. ..
  26. EPISODIC HYPOXIA AND ACUTE CEREBROVASCULAR INFLAMMATION
    JEFFREY GIDDAY; Fiscal Year: 2003
    ....
  27. ELUCIDATION OF DYSMYELINATION IN THE 18Q-SYNDROME
    Robin Leach; Fiscal Year: 2003
    ..The information from these studies could ultimately lead to therapeutic intervention for this disorder. ..