Mirlet7e

Summary

Gene Symbol: Mirlet7e
Description: microRNA let7e
Alias: Mirnlet7e, mmu-let-7e
Species: mouse

Top Publications

  1. pmc miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia
    M Ventayol
    Department of Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, Spanish Research Council IIBB CSIC, IDIBAPS, Barcelona, Spain
    Cell Death Dis 5:e1048. 2014
  2. pmc The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea
    Erin J Golden
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 112:E3864-73. 2015
  3. pmc Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching
    Hidenobu Miyazawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 144:63-73. 2017
  4. pmc miRNA let-7e modulates the Wnt pathway and early nephrogenic markers in mouse embryonic stem cell differentiation
    Jose Luis Viñas
    Departament of Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona IIBB CSIC, IDIBAPS, Barcelona, Spain
    PLoS ONE 8:e60937. 2013
  5. pmc Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation
    Rujuan Dai
    Department of Biomedical Sciences and Pathology, Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA24061 0342, USA
    Blood 112:4591-7. 2008
  6. pmc Expression of Mirlet7 family microRNAs in response to retinoic acid-induced spermatogonial differentiation in mice
    Ming Han Tong
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 85:189-97. 2011
  7. pmc MicroRNA let-7e is associated with the pathogenesis of experimental autoimmune encephalomyelitis
    Hongbing Guan
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Eur J Immunol 43:104-14. 2013
  8. pmc ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing
    Hiromitsu Ota
    The Wistar Institute, Philadelphia, PA 19104, USA
    Cell 153:575-89. 2013
  9. ncbi MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
  10. doi The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
    Agnieszka Rybak
    Center for Anatomy, Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Nat Cell Biol 11:1411-20. 2009

Scientific Experts

  • Hidenobu Miyazawa
  • Erin J Golden
  • M Ventayol
  • Jose Luis Viñas
  • Hiromitsu Ota
  • Hongbing Guan
  • Ming Han Tong
  • Ryan M O'Connell
  • Agnieszka Rybak
  • Rujuan Dai
  • Jennifer H Mansfield
  • Fumio Matsuda
  • Kurara Honda
  • Takehiro Yamamoto
  • Koki Kondo
  • Yoshifumi Yamaguchi
  • Masayuki Miura
  • Makoto Suematsu
  • Yuki Sugiura
  • Angelika Doetzlhofer
  • Ana Benito-Gonzalez
  • B Brune
  • G Hotter
  • A Sola
  • C Mastora
  • M Jung
  • J L Viñas
  • F Pi
  • Felip Pi
  • Hisashi Iizasa
  • Kazuko Nishikura
  • Davit Mrelashvili
  • Udai P Singh
  • Ravi Gupta
  • Haiping Hao
  • Narendra P Singh
  • Anna Sola
  • Ramana V Davuluri
  • Kentaro Ariyoshi
  • Michaela Jung
  • Georgina Hotter
  • Daping Fan
  • Mitzi Nagarkatti
  • Masayuki Sakurai
  • Louis Valente
  • Marina Ventayol
  • Chrysoula Mastora
  • Bernhard Brüne
  • Prakash S Nagarkatti
  • Bjorn Erik Wulff
  • Debra Mitchell
  • Ryan Evanoff
  • Michael D Griswold
  • William S J Gibson
  • Dinesh S Rao
  • David Baltimore
  • Aadel A Chaudhuri
  • Alejandro B Balazs
  • Kamyar Hadian
  • Geert Michel
  • Heiko Fuchs
  • F Gregory Wulczyn
  • Robert Nitsch
  • Daniel Krappmann
  • Ellery A Wulczyn
  • Lena Smirnova
  • Oswald Crasta
  • S Ansar Ahmed
  • Rebecca A Phillips
  • Deena Khan
  • Yan Zhang
  • Brian D Harfe
  • John Obenauer
  • Robert Nissen
  • Raphael Farzan-Kashani
  • Gary Ruvkun
  • Amy E Pasquinelli
  • Michael Zuker
  • Michael T McManus
  • Aadel Chaudhuri
  • Phillip A Sharp
  • Jalagani Srineel
  • Clifford J Tabin

Detail Information

Publications12

  1. pmc miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia
    M Ventayol
    Department of Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, Spanish Research Council IIBB CSIC, IDIBAPS, Barcelona, Spain
    Cell Death Dis 5:e1048. 2014
    ..Using luciferase reporter assays, we also showed that MMP9 is a direct target of miRNA let-7e. Thus, our results suggest that miRNA let-7e acts as a matrix metalloproteinase-9 (MMP9) inhibitor and differentiation inducer in ASCs. ..
  2. pmc The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea
    Erin J Golden
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 112:E3864-73. 2015
    ..Together, these results implicate a key role for the LIN28B/let-7 axis in regulating postnatal SC plasticity. ..
  3. pmc Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching
    Hidenobu Miyazawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 144:63-73. 2017
    ..Perturbation of glucose metabolism rewiring by suppressing Lin28a downregulation resulted in perinatal lethality. Thus, our work demonstrates that developing embryos rewire glucose metabolism following CB for normal development...
  4. pmc miRNA let-7e modulates the Wnt pathway and early nephrogenic markers in mouse embryonic stem cell differentiation
    Jose Luis Viñas
    Departament of Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona IIBB CSIC, IDIBAPS, Barcelona, Spain
    PLoS ONE 8:e60937. 2013
    ....
  5. pmc Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation
    Rujuan Dai
    Department of Biomedical Sciences and Pathology, Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA24061 0342, USA
    Blood 112:4591-7. 2008
    ..Our data are the first to demonstrate the selective regulation of miRNA expression in immune cells by estrogen and are indicative of an important role of miRNAs in estrogen-mediated immune regulation...
  6. pmc Expression of Mirlet7 family microRNAs in response to retinoic acid-induced spermatogonial differentiation in mice
    Ming Han Tong
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 85:189-97. 2011
    ..These results suggest that Mirlet7 family miRNAs play a role in retinoic acid-induced spermatogonial differentiation...
  7. pmc MicroRNA let-7e is associated with the pathogenesis of experimental autoimmune encephalomyelitis
    Hongbing Guan
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Eur J Immunol 43:104-14. 2013
    ..We also identified IL-10 as one of the functional targets of let-7e. Together, we propose that let-7e is a new miRNA involved in the regulation of encephalitogenic T-cell differentiation and the pathogenesis of EAE...
  8. pmc ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing
    Hiromitsu Ota
    The Wistar Institute, Philadelphia, PA 19104, USA
    Cell 153:575-89. 2013
    ..As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype...
  9. ncbi MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex...
  10. doi The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
    Agnieszka Rybak
    Center for Anatomy, Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Nat Cell Biol 11:1411-20. 2009
    ..Furthermore, mLin41 cooperated with the pluripotency factor Lin-28 in suppressing let-7 activity, revealing a dual control mechanism regulating let-7 in stem cells...
  11. pmc MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:14235-40. 2010
    ..Our study identifies an evolutionarily conserved subset of miRNAs that is expressed in HSCs and functions to modulate hematopoietic output...