Mir27a

Summary

Gene Symbol: Mir27a
Description: microRNA 27a
Alias: Mirn27a, mmu-mir-27a
Species: mouse

Top Publications

  1. doi miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression
    Sang Yun Kim
    Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Seoul, Republic of Korea
    Biochem Biophys Res Commun 392:323-8. 2010
  2. pmc A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 107:19879-84. 2010
  3. pmc Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
    Qinbo Zhou
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8287-92. 2011
  4. pmc SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster
    Erin Eun Young Ahn
    Moores UCSD Cancer Center, The University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:5381-8. 2013
  5. doi MicroRNA-27a promotes myoblast proliferation by targeting myostatin
    Zhiqing Huang
    Key Laboratory for Animal Disease Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Yaan, Sichuan 625014, PR China
    Biochem Biophys Res Commun 423:265-9. 2012
  6. doi TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7
    S Min
    Department of Immunology, Nankai University School of Medicine, Tianjin, China
    Genes Immun 13:621-31. 2012
  7. doi MicroRNA-27 promotes the differentiation of odontoblastic cell by targeting APC and activating Wnt/β-catenin signaling
    Min Gyeong Park
    Oral Biology Research Institute, Chosun University School of Dentistry, Gwangju 501 759, Republic of Korea
    Gene 538:266-72. 2014
  8. doi Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a
    Yiming Gong
    Department of Stomatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China
    Mol Cell Biochem 417:7-16. 2016
  9. pmc Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27
    Craig McFarlane
    Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 9:e87687. 2014
  10. pmc MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis
    Q Chen
    State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    Cell Death Dis 5:e1132. 2014

Scientific Experts

  • Boris Sabirzhanov
  • Erica Hennessy
  • Yiming Gong
  • Yanni Ma
  • Fang Wang
  • Xiaoling Chen
  • Francisco Hernández-Torres
  • Zhiqing Huang
  • Heather H Pua
  • Yunfeng Wang
  • Sunglim Cho
  • Yuanyuan Zhao
  • Youcheng Yu
  • Junwu Zhang
  • Jia Yu
  • Lei Dong
  • Michael T McManus
  • Q Chen
  • Craig McFarlane
  • Yonghua Bao
  • Maria Bouvy-Liivrand
  • Na Xie
  • Zhongchuan Wang
  • Min Gyeong Park
  • Erin Eun Young Ahn
  • Daiwen Chen
  • L Li
  • Pei Fan
  • Bum Yong Kang
  • Amelia E Aranega
  • Diego Franco
  • Valentina Libri
  • Ying Cheng
  • S Min
  • Lisa Marcinowski
  • Xuhang Liu
  • Estefanía Lozano-Velasco
  • Qinbo Zhou
  • Hitoo Nishi
  • Sang Yun Kim
  • Mohammad Q Hassan
  • David J Bates
  • Aly Azeem Khan
  • Hyang Mi Lee
  • Antonia Gallman
  • Leilani O Cruz
  • Ao Li
  • Klaus Rajewsky
  • Chen Lin
  • Ming Ling Kuo
  • Shan Sun
  • Jian Li
  • David F Steiner
  • Tomoharu Yasuda
  • Robin Kageyama
  • Ni Ting Chiou
  • Yingzi He
  • Dimitri de Kouchkovsky
  • K Mark Ansel
  • Ling li Lin
  • Lukas T Jeker
  • Cheng Jang Wu
  • Duc T Nguyen
  • Alexander Y Rudensky
  • Marina Miller
  • David H Broide
  • Li Fan Lu
  • Jeanmarie R Gonzalez
  • Sana Patel
  • David J Erle
  • Jing Lu
  • Jorge F Ortiz-Carpena
  • Xiaoping Yu
  • Xiaodong Gu
  • Huawei Li
  • Wenli Ni
  • Yufang Liu
  • Yuankai Ji
  • Tianzhi Chen
  • Jinzhu Meng
  • Meili Zhang
  • Guang Liu
  • Lanlan Wang
  • Nan Yao
  • Jianbo Yao
  • Pengchao Wang
  • Yue Huang
  • Ruiwen Fan
  • Dongmei Xu
  • Xueju Wei

Detail Information

Publications34

  1. doi miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression
    Sang Yun Kim
    Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Seoul, Republic of Korea
    Biochem Biophys Res Commun 392:323-8. 2010
    ..Together, these results suggest that miR-27a would suppress adipocyte differentiation through targeting PPARgamma and thereby down-regulation of miR-27a might be associated with adipose tissue dysregulation in obesity...
  2. pmc A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 107:19879-84. 2010
    ..Taken together, we have established a regulatory network with a central role for the miR cluster 23a∼27a∼24-2 in both progression and maintenance of the osteocyte phenotype...
  3. pmc Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters
    Qinbo Zhou
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8287-92. 2011
    ..Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders...
  4. pmc SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster
    Erin Eun Young Ahn
    Moores UCSD Cancer Center, The University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:5381-8. 2013
    ..Our data revealed a previously unidentified role of SON in microRNA production via regulating the transcription process, thereby modulating GATA-2 at the protein level during hematopoietic differentiation...
  5. doi MicroRNA-27a promotes myoblast proliferation by targeting myostatin
    Zhiqing Huang
    Key Laboratory for Animal Disease Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Yaan, Sichuan 625014, PR China
    Biochem Biophys Res Commun 423:265-9. 2012
    ..In addition, the miR-27a was confirmed to target myostatin 3'UTR by a luciferase reporter analysis. Together, these results suggest that miR-27a promotes myoblast proliferation through targeting myostatin...
  6. doi TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7
    S Min
    Department of Immunology, Nankai University School of Medicine, Tianjin, China
    Genes Immun 13:621-31. 2012
    ..The repeated infusion of miR-27a-engineered DCs into tumor tissues accelerated tumor growth, indicating that miR-27a is a potential target for tumor immunotherapy...
  7. doi MicroRNA-27 promotes the differentiation of odontoblastic cell by targeting APC and activating Wnt/β-catenin signaling
    Min Gyeong Park
    Oral Biology Research Institute, Chosun University School of Dentistry, Gwangju 501 759, Republic of Korea
    Gene 538:266-72. 2014
    ..Therefore, miR-27 might be considered a critical candidate as an odontoblastic differentiation molecular target for the development of miRNA based therapeutic agents in the dental medicine...
  8. doi Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a
    Yiming Gong
    Department of Stomatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China
    Mol Cell Biochem 417:7-16. 2016
    ..Our results suggest that expression of Sp7 during the early stage of Satb2-induced osteogenic differentiation of BMSCs is regulated by miR-27a. ..
  9. pmc Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27
    Craig McFarlane
    Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 9:e87687. 2014
    ..Therefore, miR-27a/b, through negatively regulating Mstn, plays a role in promoting satellite cell activation, myoblast proliferation and preventing muscle wasting. ..
  10. pmc MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis
    Q Chen
    State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    Cell Death Dis 5:e1132. 2014
    ..Our findings may also have implications for the potential target role of microRNAs in the treatment of neuronal apoptosis-related diseases. ..
  11. pmc miR-27a regulates inflammatory response of macrophages by targeting IL-10
    Na Xie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294
    J Immunol 193:327-34. 2014
    ..In conclusion, our study identified miR-27a downregulation as a negative-regulatory mechanism that prevents overly exuberant TLR2- and TLR4-driven inflammatory responses. ..
  12. doi miR-27a is up regulated and promotes inflammatory response in sepsis
    Zhongchuan Wang
    Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
    Cell Immunol 290:190-5. 2014
    ....
  13. doi Identification of regulatory elements directing miR-23a-miR-27a-miR-24-2 transcriptional regulation in response to muscle hypertrophic stimuli
    Francisco Hernández-Torres
    Cardiovascular Research Group, Department of Experimental Biology, University of Jaen, Jaen, Spain
    Biochim Biophys Acta 1839:885-97. 2014
    ..Taking together, our results provide new insights into the regulatory networks driving miR-23a-miR-27a-miR-24-2 cluster expression in cardiac and skeletal muscles. ..
  14. pmc Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins
    Boris Sabirzhanov
    Department of Anesthesiology and Center for Shock, Trauma, and Anesthesiology Research, University of Maryland School of Medicine
    J Neurosci 34:10055-71. 2014
    ..These findings indicate that post-traumatic decreases in miR-23a and miR-27a contribute to neuronal cell death after TBI by upregulating proapoptotic Bcl-2 family members, thus providing a novel therapeutic target. ..
  15. pmc Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2
    Yonghua Bao
    Department of Immunology, Xinxiang Medical University, Xinxiang, China
    PLoS ONE 9:e105991. 2014
    ..Therefore, miR-27a could be a useful biomarker for monitoring colorectal cancer development and progression, and also could have a therapeutic potential by targeting SGPP1, Smad2 and STAT3 for colorectal cancer therapy. ..
  16. pmc Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells
    Yanni Ma
    State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
    EMBO J 34:361-78. 2015
    ..Altogether, our findings uncover the essential role of miR-27 and miR-24 in ESC differentiation and also demonstrate novel microRNAs responsible for ESC differentiation. ..
  17. pmc MicroRNA-27a-3p Inhibits Melanogenesis in Mouse Skin Melanocytes by Targeting Wnt3a
    Yuanyuan Zhao
    College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030801, China
    Int J Mol Sci 16:10921-33. 2015
    ..Previous studies reported that Wnt3a promoted melanogenensis in mouse melanocytes. Thus, miR-27-3p inhibits melanogenesis by repressing Wnt3a protein expression. ..
  18. ncbi Mir-27a promotes apoptosis of cochlear sensory epithelium in Cx26 knockout mice
    Yunfeng Wang
    Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Building 9 Room 611, 83 Fenyang Road, Xuhui District, Shanghai 200031, China
    Front Biosci (Landmark Ed) 21:364-73. 2016
    ..Thus, mir-27a was identified as an apoptotic molecule that participates in Cx26 knockout-induced apoptosis in the cochlear sensory epithelium of mice by downregulating sgk1 expression. ..
  19. pmc miR-23∼27∼24 clusters control effector T cell differentiation and function
    Sunglim Cho
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093
    J Exp Med 213:235-49. 2016
    ....
  20. pmc MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production
    Heather H Pua
    Department of Pathology, University of California, San Francisco, San Francisco, CA, USA
    Immunity 44:821-32. 2016
    ..Thus, elucidating the biological function and target repertoire of miR-24 and miR-27 reveals regulators of Th2 cell biology...
  21. pmc Combinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis
    Maria Bouvy-Liivrand
    Life Sciences Research Unit University of Luxembourg Luxembourg, Luxembourg Luxembourg Centre for Systems Biomedicine University of Luxembourg Esch Sur Alzette, Luxembourg
    RNA Biol 11:76-91. 2014
    ..The obtained results might offer an explanation to the dysregulation of LPL in diabetic conditions and could be extended to quantitative modeling of regulation of other metabolic genes under similar regulatory network motifs. ..
  22. pmc Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature
    Bum Yong Kang
    Departments of Medicine, Atlanta Veterans Affairs Medical Centers and Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e79503. 2013
    ....
  23. doi MicroRNA expression signature for Satb2-induced osteogenic differentiation in bone marrow stromal cells
    Yiming Gong
    Department of Stomatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China
    Mol Cell Biochem 387:227-39. 2014
    ..In this study, we identified that a number of differentially regulated miRNAs, whose target genes involved in the TGF-β/BMP signaling pathway, play an important role in the early stage of Satb2-induced osteogenic differentiation. ..
  24. doi Role of microRNA-27a in myoblast differentiation
    Xiaoling Chen
    Key Laboratory for Animal Disease Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, 611130, P R China
    Cell Biol Int 38:266-71. 2014
    ..Overexpression of miR-27a increased the number of myosin heavy chain (MHC)-positive cells and upregulated mRNA and protein of MyoD and myogenin. These findings indicate that miR-27a plays a role in enhancing myoblast differentiation. ..
  25. pmc A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis
    Fang Wang
    Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Beijing 100005, PR China, Zebrafish Core Facility, State Key Laboratory of Medical Molecular Sciences, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, PR China, Department of Biomedical Engineering, School of Computation and Information Technology, Beijing Jiaotong University, Beijing 100044, PR China, Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China and Cancer center, the General Hospital of the People s Liberation Army, Beijing 100853, PR China
    Nucleic Acids Res 42:442-57. 2014
    ..Taken together, these data integrated micro RNA expression and function into GATA factor coordinated networks and provided mechanistic insight into a regulatory circuit that comprised GATA1/2 switch and miR-27a/24 in erythropoiesis...
  26. pmc miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival
    Pei Fan
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    PLoS ONE 8:e60888. 2013
    ..Using bioinformatics approach, the interactions between dysregulated miRNAs and their target genes were analyzed. Our data demonstrated that Drosha is required for VSMC survival by targeting multiple signaling pathways...
  27. pmc Precursor microRNA-programmed silencing complex assembly pathways in mammals
    Xuhang Liu
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell 46:507-17. 2012
    ..Our studies provide a comprehensive view of miRNP/RISC assembly pathways in mammals, and our assay provides a versatile platform for further mechanistic dissection of such pathways in mammals...
  28. pmc Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo
    Lisa Marcinowski
    Max von Pettenkofer Institute, Ludwig Maximilians University Munich, Munich, Germany
    PLoS Pathog 8:e1002510. 2012
    ....
  29. doi Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells
    Ying Cheng
    College of Agriculture, Hainan Key Lab of Tropical Animal Reproduction and Breeding and Epidemic Disease Research Construction Period, Animal Genetic Engineering Key Lab of Haikou, Hainan University, Haidian Island, Haikou, 570228, People s Republic of China
    Inflammation 35:1308-13. 2012
    ..Our findings may provide the basic information for the precise roles of miRNAs in the macrophage inflammatory response to LPS stimulation in the future...
  30. pmc Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target
    Valentina Libri
    Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 109:279-84. 2012
    ..This virus-host interaction reveals a mode of miRNA regulation in which a mRNA directs the degradation of a miRNA. We speculate that RNA-mediated miRNA degradation could be a more general viral strategy for manipulating host cells...
  31. doi Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells
    Erica Hennessy
    National Institute of Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Biochem Biophys Res Commun 396:457-62. 2010
    ..In this study, we have also identified 21 miRNAs not previously known to have a potential murine homologue...
  32. doi Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis
    Estefanía Lozano-Velasco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Spain
    Dev Biol 357:165-78. 2011
    ..Therefore, this study sheds light on previously unknown function of Pitx2c balancing the different myogenic progenitor populations during myogenesis...
  33. pmc MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes
    Hitoo Nishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 31:744-55. 2011
    ..These findings suggested that miR-27a regulates β-MHC gene expression by targeting TRβ1 in cardiomyocytes...
  34. pmc MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging
    David J Bates
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Aging Cell 9:1-18. 2010
    ..Furthermore, compared to its normal siblings, the dwarf mouse exhibits a head start in regulating these pathways to control their normality, which may ultimately contribute to its extended health-span and longevity...