Mir200b

Summary

Gene Symbol: Mir200b
Description: microRNA 200b
Alias: Mirn200b
Species: mouse

Top Publications

  1. doi A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    Cameron P Bracken
    Hanson Institute, Institute of Medical and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia
    Cancer Res 68:7846-54. 2008
  2. pmc Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2
    Yuk Cheung Chan
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Arterioscler Thromb Vasc Biol 32:1372-82. 2012
  3. doi miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy
    Biao Feng
    Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada Medical Research Center, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, People s Republic of China
    Diabetes 65:768-79. 2016
  4. pmc High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress
    Hui Gu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD
    Diabetes 65:149-63. 2016
  5. pmc Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA
    Sachin S Hajarnis
    From the Departments of Internal Medicine and
    J Biol Chem 290:24793-805. 2015
  6. pmc microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs
    Yi Pan
    a Jiangsu Engineering Research Center for microRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing, Jiangsu, China
    RNA Biol 12:276-89. 2015
  7. pmc Sonic hedgehog increases the skin wound-healing ability of mouse embryonic stem cells through the microRNA 200 family
    Han Na Suh
    Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea
    Br J Pharmacol 172:815-28. 2015
  8. doi MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein
    Chen Geng Liu
    Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, No 45 Changchun Road, Beijing, 100053, People s Republic of China
    Brain Res 1583:55-64. 2014
  9. pmc Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition
    Natasha Kolesnikoff
    From the Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 289:11194-205. 2014
  10. pmc RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2
    M Sun
    1 Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA 2 Committee On Genetics, Genomics and System Biology, University of Chicago, Chicago, IL, USA
    Oncogene 33:3528-37. 2014

Scientific Experts

  • Ronna Hertzano
  • Vishal Patel
  • Derek M Dykxhoorn
  • Mitsuo Kato
  • Jeong Oh Shin
  • Natasha Kolesnikoff
  • Hui Gu
  • Biao Feng
  • Han Na Suh
  • Sachin S Hajarnis
  • Yi Pan
  • Chen Geng Liu
  • M Sun
  • Li xiang Xue
  • Hidetoshi Hasuwa
  • Sung Hee Chang
  • Chun xia Yao
  • Jung Tak Park
  • L Guo
  • Rama Natarajan
  • Mei Wang
  • Linda Lanting
  • Ling Li
  • Marpadga A Reddy
  • Changgeng Peng
  • Shanzhong Yang
  • Kyoung Won Cho
  • Cristel Archambaud
  • Sung Won Cho
  • Jong Min Lee
  • Yuk Cheung Chan
  • Han Sung Jung
  • Emma Juuri
  • Vidya K Nagalakshmi
  • Andrew G Bert
  • Mark J Schliekelman
  • Srikanth Nagalla
  • Philip A Gregory
  • Gregory J Goodall
  • Nathan Salomonis
  • Nora E Renthal
  • Enpeng Zhao
  • Cameron P Bracken
  • Rui Yi
  • Nanna Rønbjerg Christoffersen
  • Thomas Andl
  • Jian Ying Wang
  • Subrata Chakrabarti
  • Qun Zhou
  • Shali Chen
  • Xuran Chu
  • Daoyin Dong
  • Yanhui Chu
  • Peixin Yang
  • Shengyun Fang
  • Yanan Cao
  • Jingwen Yu
  • Marco Pontoglio
  • Hongwei Liang
  • Ho Jae Han
  • Xi Chen
  • Suyang Zhang
  • Xin Yan
  • Chihao Zhao
  • Feng Wang
  • Massimo Attanasio
  • Patricia Cobo-Stark
  • Weixu Chen
  • Chen Yu Zhang
  • Yanqing Liu
  • Nan Wang
  • Junfeng Zhang
  • Ke Zen
  • Hongwei Gu
  • Peter Igarashi
  • Hongjie Zhang
  • Karam Aboudehen
  • K K Chada
  • Lei Li
  • Joanne L Attema
  • Jin Ling Wang
  • Suraya Roslan
  • P Chen
  • C H Chung
  • Pei chang Wang
  • D Sankarasharma
  • S Gomes
  • C A Frankenberger
  • Yue Qi Zhang
  • Quenten P Schwarz

Detail Information

Publications36

  1. doi A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    Cameron P Bracken
    Hanson Institute, Institute of Medical and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia
    Cancer Res 68:7846-54. 2008
    ..These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression...
  2. pmc Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2
    Yuk Cheung Chan
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Arterioscler Thromb Vasc Biol 32:1372-82. 2012
    ..MicroRNAs (miRs) regulate angiogenesis by posttranscriptional silencing of target genes. The significance of angiostatic miR-200b in switching on skin wound angiogenesis was tested...
  3. doi miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy
    Biao Feng
    Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada Medical Research Center, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, People s Republic of China
    Diabetes 65:768-79. 2016
    ..These data indicate that glucose-induced EndMT in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR-200b and p300...
  4. pmc High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress
    Hui Gu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD
    Diabetes 65:149-63. 2016
    ..Thus, we showed a novel function of miR-200b and CITED2 in high glucose-induced UPR and ER stress, suggesting that miR-200b and CITED2 are critical for ER homeostasis and NTD formation in the developing embryo...
  5. pmc Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA
    Sachin S Hajarnis
    From the Departments of Internal Medicine and
    J Biol Chem 290:24793-805. 2015
    ..These studies reveal a novel pathway whereby HNF-1β directly contributes to the control of miRNAs that are involved in epithelial-mesenchymal transition and cystic kidney disease...
  6. pmc microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs
    Yi Pan
    a Jiangsu Engineering Research Center for microRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing, Jiangsu, China
    RNA Biol 12:276-89. 2015
    ..Taken together, our results demonstrate that miR-200b/c play a critical role in promoting colorectal tumorigenesis through inhibiting RECK expression and subsequently triggering SKP2 elevation and p27(Kip1) degradation. ..
  7. pmc Sonic hedgehog increases the skin wound-healing ability of mouse embryonic stem cells through the microRNA 200 family
    Han Na Suh
    Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea
    Br J Pharmacol 172:815-28. 2015
    ..The present study investigated the effect of mESCs with shh in skin recovery in vivo as well as the related intracellular signal pathways in vitro...
  8. doi MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein
    Chen Geng Liu
    Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, No 45 Changchun Road, Beijing, 100053, People s Republic of China
    Brain Res 1583:55-64. 2014
    ..05). In conclusion, these findings showed that miR-135a, -200b and -429 may take part in the progress of AD; miR-200b was of great potential as noninvasive and easily detected blood-based biomarkers of MCI and DAT patients. ..
  9. pmc Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition
    Natasha Kolesnikoff
    From the Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 289:11194-205. 2014
    ..Together, these findings indicate that miR-200 family members require Sp1 to drive basal expression and to maintain an epithelial state. ..
  10. pmc RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2
    M Sun
    1 Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA 2 Committee On Genetics, Genomics and System Biology, University of Chicago, Chicago, IL, USA
    Oncogene 33:3528-37. 2014
    ..Taken together, our findings reveal two novel signaling pathways targeted by the metastasis suppressor RKIP that regulate remodeling of the extracellular matrix and tumor survival. ..
  11. pmc miR-200b targets GATA-4 during cell growth and differentiation
    Chun xia Yao
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou City, China
    RNA Biol 10:465-80. 2013
    ..Thus, miR-200b targets GATA-4 to downregulate the expression of cyclin D1 and myosin heavy chain (MHC), thereby regulating cell growth and differentiation...
  12. doi Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition
    L Guo
    Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences, Beijing, P R China
    Oncogene 32:5272-82. 2013
    ..These findings highlight the importance of Stat3-coordinated Lin-28B-let-7-HMGA2 and miR-200-ZEB1 circuits in the cytokine-mediated phenotypic reprogramming of breast cancer cells. ..
  13. pmc A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Kidney Int 80:358-68. 2011
    ..Thus, miRNA-regulated circuits may amplify TGF-β1 signaling, accelerating chronic fibrotic diseases such as diabetic nephropathy...
  14. pmc FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy
    Jung Tak Park
    Division of Molecular Diabetes Research, Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 288:22469-80. 2013
    ..These data suggest a new mechanism for TGF-β-induced Akt activation through FOG2 down-regulation by miR-200b/c, which can lead to glomerular mesangial hypertrophy in the progression of diabetic nephropathy. ..
  15. doi MiR-200b is involved in Tgf-β signaling to regulate mammalian palate development
    Jeong Oh Shin
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei University, 50 Yonsei ro, Seodaemoon Gu, Seoul 120 752, Korea
    Histochem Cell Biol 137:67-78. 2012
    ..Elucidating the mechanism of palatogenesis may aid the design of effective gene-based therapies for the treatment of congenital cleft palate...
  16. pmc Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney
    Vidya K Nagalakshmi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Kidney Int 79:317-30. 2011
    ..Furthermore, an understanding of miRNA action may provide new insights into the etiology and pathogenesis of renal cyst-based kidney disease...
  17. doi miR-200b and miR-429 function in mouse ovulation and are essential for female fertility
    Hidetoshi Hasuwa
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Science 341:71-3. 2013
    ..Our results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. Thus, the hypothalamo-pituitary-ovarian axis was shown to require miR-200b and miR-429 to support ovulation. ..
  18. pmc Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer
    Mark J Schliekelman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 71:7670-82. 2011
    ..Lastly, we identified ECM proteins and peptidases that were directly regulated by miR-200. Taken together, our results reveal how expression of miR-200 alters the tumor microenvironment to inhibit the processes of EMT and metastasis...
  19. pmc Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis
    Sung Hee Chang
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
    J Biol Chem 288:4908-21. 2013
    ..Together, these studies reveal an evolutionarily conserved post-transcriptional mechanism involving competitive interactions between HuR and miR-200b that controls angiogenesis...
  20. pmc MicroRNAs regulate renal tubule maturation through modulation of Pkd1
    Vishal Patel
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, MC 8856, Dallas, TX 75390, USA
    J Am Soc Nephrol 23:1941-8. 2012
    ..In conclusion, miRNAs are essential for the maturation of renal tubules, and Pkd1 is a target of miR-200. These results also suggest that miRNAs may modulate PKD1 gene dosage and play a role in the initiation of cystogenesis...
  21. pmc Impact of lactobacilli on orally acquired listeriosis
    Cristel Archambaud
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:16684-9. 2012
    ..monocytogenes infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of L. monocytogenes transcriptome...
  22. pmc A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation
    Changgeng Peng
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, Deutsches Forschungszentrum für Umwelt und Gesundheit, and Technische Universität München Weihenstephan, D 85764 Neuherberg, Germany
    J Neurosci 32:13292-308. 2012
    ....
  23. pmc Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors
    Emma Juuri
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Cell 23:317-28. 2012
    ..The identification of Sox2 as a marker for the dental epithelial stem cells will facilitate further studies on their lineage segregation and differentiation during tooth renewal...
  24. pmc Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis
    Ronna Hertzano
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
    PLoS Genet 7:e1002309. 2011
    ..Our approach can be employed to decipher additional complex regulatory networks underlying other hearing and balance mouse mutants...
  25. doi miR-200b regulates cell migration via Zeb family during mouse palate development
    Jeong Oh Shin
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Research Center, College of Dentistry, Yonsei University, Seodaemoon Gu, Seoul, Korea
    Histochem Cell Biol 137:459-70. 2012
    ..These results suggest that miR-200b plays crucial roles in cell migration and palatal fusion by regulating Zeb1 and Zeb2 as a noncoding RNA during palate development...
  26. pmc Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice
    Marpadga A Reddy
    Department of Diabetes, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Arterioscler Thromb Vasc Biol 32:721-9. 2012
    ..We examined the role of microRNA(miR)-200 family members and their target Zeb1, an E-box binding transcriptional repressor, in these events...
  27. pmc Participation of miR-200 in pulmonary fibrosis
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 180:484-93. 2012
    ..Thus, the miR-200 family members participate importantly in fibrotic lung diseases and suggest that restoring miR-200 expression in the lungs may represent a novel therapeutic approach in treating pulmonary fibrotic diseases...
  28. doi MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells
    Ling Li
    State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, PR China
    J Cell Biochem 113:1235-44. 2012
    ..We thus conclude that miR-17-92 cluster could inhibit TGFB pathway induced proliferation inhibition and collagen synthesis in PMCs by directly targeting TGFBR2, SMAD2, and SMAD4...
  29. pmc miR-200b mediates post-transcriptional repression of ZFHX1B
    Nanna Rønbjerg Christoffersen
    Biotech Research and Innovation Centre, Copenhagen, Denmark
    RNA 13:1172-8. 2007
    ..Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter...
  30. pmc The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles
    Thomas Andl
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 16:1041-9. 2006
    ..These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function...
  31. pmc A skin microRNA promotes differentiation by repressing 'stemness'
    Rui Yi
    Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10065, USA
    Nature 452:225-9. 2008
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers...
  32. pmc Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice
    Enpeng Zhao
    Biochemistry Department, University of Wisconsin, Madison, WI 53706, USA
    Mamm Genome 20:476-85. 2009
    ..Understanding the influence that obesity and genetics exert on the regulation of miRNA expression will reveal the role miRNAs play in the context of obesity-induced type 2 diabetes...
  33. pmc miR-200 enhances mouse breast cancer cell colonization to form distant metastases
    Derek M Dykxhoorn
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7181. 2009
    ..Because some miRNAs are dysregulated in cancer and affect cellular transformation, tumor formation, and metastasis, we examined whether changes in miRNA expression might explain the differences in metastasis of these cells...
  34. pmc Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation
    Nathan Salomonis
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:10514-9. 2010
    ..The findings herein illustrate a critical role for AS in the specification of ES cells with differentiation, and highlight the utility of global functional analyses of AS...
  35. pmc miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
    Nora E Renthal
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:20828-33. 2010
    ....
  36. pmc Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity
    Srikanth Nagalla
    Thomas Jefferson University, Cardeza Foundation for Hematologic Research, and the Department of Medicine, Jefferson Medical College, Philadelphia, PA, USA
    Blood 117:5189-97. 2011
    ....