Mir200a

Summary

Gene Symbol: Mir200a
Description: microRNA 200a
Alias: Mirn200a
Species: mouse

Top Publications

  1. doi A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    Cameron P Bracken
    Hanson Institute, Institute of Medical and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia
    Cancer Res 68:7846-54. 2008
  2. pmc miR-200 enhances mouse breast cancer cell colonization to form distant metastases
    Derek M Dykxhoorn
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7181. 2009
  3. doi miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
    Bogdan Mateescu
    Stress and Cancer Laboratory, Institut Curie, Paris, France
    Nat Med 17:1627-35. 2011
  4. pmc C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21
    Hao Wu
    Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang St, Changchun, Jilin, 130041, People s Republic of China
    Diabetologia 59:1558-68. 2016
  5. doi MicroRNA-141-3p and miR-200a-3p regulate insulin-like growth factor 2 during mouse placental development
    Sarbani Saha
    Division of Cell Biology and Physiology, CSIR Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India
    Mol Cell Endocrinol 414:186-93. 2015
  6. doi miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene
    Efrosini Tsouko
    Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA
    Carcinogenesis 36:1051-60. 2015
  7. doi MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage
    M Umeda
    Department of Orthodontics, Kyushu University Hospital, Fukuoka, Japan
    J Dent Res 94:795-802. 2015
  8. pmc MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells
    Rajnikumar Sangani
    Department of Orthopaedic Surgery, Georgia Regents University, Augusta, GA 30912, USA
    Mol Cell Endocrinol 410:19-26. 2015
  9. pmc Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    Limo Chen
    1 Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 2 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Commun 5:5241. 2014
  10. doi Mechanisms of endothelial to mesenchymal transition in the retina in diabetes
    Yanan Cao
    Department of Pathology, Western University, London, Ontario, Canada Medical Research Center, Mudanjiang Medical University, Mudanjiang, Heilongjiang, People s Republic of China
    Invest Ophthalmol Vis Sci 55:7321-31. 2014

Scientific Experts

  • Kentaro Nagaoka
  • Zeinab K Hassan
  • Tomohiro Itoh
  • Derek M Dykxhoorn
  • Erica Hennessy
  • Jonathon D Roybal
  • Natasha Kolesnikoff
  • Jonathan M Kurie
  • Don L Gibbons
  • Young Ho Ahn
  • Hao Wu
  • Sarbani Saha
  • Rajnikumar Sangani
  • Efrosini Tsouko
  • M Umeda
  • Thad Sharp
  • Jie Wei
  • Limo Chen
  • Hirofumi Haraguchi
  • Yanan Cao
  • Delphine Crépin
  • Michihiro Toritsuka
  • Lian Ju Shen
  • Yang Liu
  • John V Heymach
  • Christin Ungewiss
  • Koriand r C Williams
  • Shanzhong Yang
  • Jun Wang
  • Bogdan Mateescu
  • Chad J Creighton
  • Manav Korpal
  • Philip A Gregory
  • Gregory J Goodall
  • Priyanka Pandey
  • Andrew G Bert
  • Mark J Schliekelman
  • Nicholas J Hand
  • Cameron P Bracken
  • Thomas Andl
  • Paul N Epstein
  • Lining Miao
  • Yi Tan
  • Jun Zeng
  • Lu Cai
  • XiangMei Chen
  • Lili Kong
  • Guang Liang
  • Junlian Gu
  • Maiying Kong
  • Daniel E Frigo
  • Monte Hunter
  • K Miyazaki
  • Sudharsan Periyasamy-Thandavan
  • Rupasri Ain
  • Norman Chutkan
  • Eylem Aydogdu
  • William D Hill
  • F Terao
  • Carlos Isales
  • Cecilia Williams
  • Ravindra Kolhe
  • I Takahashi
  • Mark Hamrick
  • K Yoshizaki
  • Sadanand Fulzele
  • Maryka H Bhattacharyya
  • Jaganmoy Choudhury
  • Melanie Mediavilla-Varela
  • Jing Wang
  • Di Peng
  • Mohammed Taouis
  • Takehiro Hiraoka
  • Huojun Cao
  • Yasushi Hirota
  • Mitsunori Matsuo
  • Yanhui Chu
  • Longxin Qiu
  • Li Yuan
  • Xuejun Zhang
  • Tao Wang
  • Shanshan Wang
  • Brad A Amendt
  • Xiao Li
  • Gordon Robertson
  • Kaori Koga
  • Naoko Yamauchi
  • Arieh Gertler
  • Dan Song
  • David Peng

Detail Information

Publications30

  1. doi A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    Cameron P Bracken
    Hanson Institute, Institute of Medical and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia
    Cancer Res 68:7846-54. 2008
    ..These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression...
  2. pmc miR-200 enhances mouse breast cancer cell colonization to form distant metastases
    Derek M Dykxhoorn
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7181. 2009
    ..Because some miRNAs are dysregulated in cancer and affect cellular transformation, tumor formation, and metastasis, we examined whether changes in miRNA expression might explain the differences in metastasis of these cells...
  3. doi miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
    Bogdan Mateescu
    Stress and Cancer Laboratory, Institut Curie, Paris, France
    Nat Med 17:1627-35. 2011
    ..The miR200a-dependent stress signature correlates with improved survival of patients in response to treatment...
  4. pmc C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21
    Hao Wu
    Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang St, Changchun, Jilin, 130041, People s Republic of China
    Diabetologia 59:1558-68. 2016
    ..The present study aimed to define the mechanism by which C66 ameliorates diabetic nephropathy...
  5. doi MicroRNA-141-3p and miR-200a-3p regulate insulin-like growth factor 2 during mouse placental development
    Sarbani Saha
    Division of Cell Biology and Physiology, CSIR Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India
    Mol Cell Endocrinol 414:186-93. 2015
    ..Our study provides evidence for regulation of Igf2 by microRNAs and further elucidates the role of miR141-3p and miR-200a-3p in the mouse placental development. ..
  6. doi miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene
    Efrosini Tsouko
    Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA
    Carcinogenesis 36:1051-60. 2015
    ..The miR-200a-EPHA2 axis is a novel mechanism highlighting the possibility of utilizing miR-200a delivery to target TNBC metastases. ..
  7. doi MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage
    M Umeda
    Department of Orthodontics, Kyushu University Hospital, Fukuoka, Japan
    J Dent Res 94:795-802. 2015
    ..These results indicate that miR-200a contributed to chondrogenesis in developing MCC by controlling proliferation and differentiation in MCC cells. ..
  8. pmc MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells
    Rajnikumar Sangani
    Department of Orthopaedic Surgery, Georgia Regents University, Augusta, GA 30912, USA
    Mol Cell Endocrinol 410:19-26. 2015
    ..Taken together, these results indicate that both miRNAs are novel regulators of the SVCT2 transporter and play an important role in the osteogenic differentiation of BMSCs. ..
  9. pmc Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    Limo Chen
    1 Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 2 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Commun 5:5241. 2014
    ....
  10. doi Mechanisms of endothelial to mesenchymal transition in the retina in diabetes
    Yanan Cao
    Department of Pathology, Western University, London, Ontario, Canada Medical Research Center, Mudanjiang Medical University, Mudanjiang, Heilongjiang, People s Republic of China
    Invest Ophthalmol Vis Sci 55:7321-31. 2014
    ..We investigated mechanisms of such changes in the retinal endothelial cells and in the retina of diabetic animals...
  11. pmc A pituitary homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin pathway converts mesenchymal cells to amelogenin-expressing dental epithelial cells
    Thad Sharp
    From the Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
    J Biol Chem 289:27327-41. 2014
    ..This pathway and reprogramming can be used to reprogram mesenchymal or oral epithelial cells to dental epithelial (ameloblast) cells, which can be used in tissue repair and regeneration studies. ..
  12. pmc MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation
    Hirofumi Haraguchi
    Department of Obstetrics and Gynecology H H, T S F, Y H, M E, L M, M M, T H, K K, T F, Y O and Department of Pathology N Y, M F, Graduate School of Medicine Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences M E the University of Tokyo, Tokyo 113 8655, Japan Precursory Research for Embryonic Science and Technology Y H, Japan Science and Technology Agency, Saitama 332 0012, Japan and Division of Reproductive Sciences A B, J C, S K D, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229
    Mol Endocrinol 28:1108-17. 2014
    ..These findings may point toward not only the physiological but also the pathological basis of the cervical milieu in embryo implantation...
  13. pmc Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition
    Natasha Kolesnikoff
    From the Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 289:11194-205. 2014
    ..Together, these findings indicate that miR-200 family members require Sp1 to drive basal expression and to maintain an epithelial state. ..
  14. doi The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment
    Delphine Crépin
    CNRS, Center of Neurosciences Paris Sud, UMR 8195, Orsay Cedex F 91405, France University Paris Sud, UMR 8195, Orsay Cedex F 91405, France
    Mol Cell Endocrinol 384:1-11. 2014
    ..These findings link the alteration of leptin and insulin signaling to the up-regulation of hypothalamic miR-200a which could be a new target for treatment of obesity. ..
  15. doi Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice
    Jie Wei
    State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiang an, Xiamen, 361102, China
    Free Radic Biol Med 67:91-102. 2014
    ....
  16. pmc MicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm
    Yang Liu
    Department of Laboratory Medicine and Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    PLoS ONE 8:e68990. 2013
    ..Collectively, our results demonstrate that miR-200a plays critical roles in ES cell lineage commitment by directly regulating Grb2 expression and Erk signaling. ..
  17. pmc Epithelial cell differentiation regulated by MicroRNA-200a in mammary glands
    Kentaro Nagaoka
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan
    PLoS ONE 8:e65127. 2013
    ..These observations suggest that miR-200a is important for maintaining the epithelial cell phenotype, which contributes to lactogenic hormone induction of cellular differentiation in mammary glands...
  18. pmc Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus
    Lian Ju Shen
    1Laboratory of Reproductive Biology, Chongqing Medical University, Chongqing, People s Republic of China
    Reprod Sci 20:1518-28. 2013
    ..Thus, clarifying the physiological functions of uterine miRNAs will help to elucidate the embryo implantation process and may even contribute to curing infertility and inventing new contraceptives. ..
  19. pmc Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model
    Michihiro Toritsuka
    Research Institute, Shiga Medical Center, Shiga 524 8524, Japan
    Proc Natl Acad Sci U S A 110:17552-7. 2013
    ....
  20. ncbi Curcumin reorganizes miRNA expression in a mouse model of liver fibrosis
    Zeinab Korany Hassan
    Department of Zoology, Center for Scientific and Medical Female Colleges, King Saud University, Riyadh, Saudi Arabia
    Asian Pac J Cancer Prev 13:5405-8. 2012
    ..This is the first study that highlighted the effect of curcumin on liver fibrosis through regulation of miRNAs...
  21. pmc MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor
    Koriand r C Williams
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:7529-34. 2012
    ....
  22. pmc Participation of miR-200 in pulmonary fibrosis
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 180:484-93. 2012
    ..Thus, the miR-200 family members participate importantly in fibrotic lung diseases and suggest that restoring miR-200 expression in the lungs may represent a novel therapeutic approach in treating pulmonary fibrotic diseases...
  23. pmc Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer
    Mark J Schliekelman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 71:7670-82. 2011
    ..Lastly, we identified ECM proteins and peptidases that were directly regulated by miR-200. Taken together, our results reveal how expression of miR-200 alters the tumor microenvironment to inhibit the processes of EMT and metastasis...
  24. pmc Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Med 17:1101-8. 2011
    ..Overall, these findings suggest a pleiotropic role of miR-200s in promoting metastatic colonization by influencing E-cadherin-dependent epithelial traits and Sec23a-mediated tumor cell secretome...
  25. pmc Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease
    Priyanka Pandey
    Department of Medicine, Children s Hospital Boston Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    BMC Syst Biol 5:56. 2011
    ..miRNAs are small, regulatory non-coding RNAs, implicated in a wide spectrum of biological processes. Their expression levels are altered in several diseases including kidney cancer, diabetic nephropathy and PKD...
  26. pmc miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1
    Jonathon D Roybal
    University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cancer Res 9:25-35. 2011
    ..Flt1 knockdown decreased the growth and metastasis of tumor cells in syngeneic mice. We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1...
  27. doi Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells
    Erica Hennessy
    National Institute of Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Biochem Biophys Res Commun 396:457-62. 2010
    ..In this study, we have also identified 21 miRNAs not previously known to have a potential murine homologue...
  28. pmc MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 284:19272-9. 2009
    ..Thus, we have observed for the first time that miR-141 and -200a are involved in pre-osteoblast differentiation in part by regulating the expression of Dlx5...
  29. pmc The microRNA-30 family is required for vertebrate hepatobiliary development
    Nicholas J Hand
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Gastroenterology 136:1081-90. 2009
    ..To address this issue, we characterized miRNA expression in the embryonic mouse liver, performed functional miRNA analysis in zebrafish larvae, and identified novel hepatic miRNA targets...
  30. pmc The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles
    Thomas Andl
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 16:1041-9. 2006
    ..These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function...