Genomes and Genes
Gene Symbol: Met
Description: met proto-oncogene
Alias: AI838057, HGF, HGFR, Par4, c-Met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, met proto-oncogene tyrosine kinase, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met
Publications114 found, 100 shown here
- Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouseG Daston
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Development 122:1017-27. 1996..The failure of limb muscle precursors to invade the limb in splotch mice is associated with the absence of c-met expression in premigratory cells, together with a change in the morphology of the ventral dermomyotome...
- Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factorS Rong
ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
Mol Cell Biol 12:5152-8. 1992The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells...
- Structure, tissue-specific expression, and transforming activity of the mouse met protooncogeneA Iyer
Rush Presbyterian St Luke s Medical Center, Medical Oncology Department, Chicago, Illinois 60612
Cell Growth Differ 1:87-95. 1990A 6.7-kilobase met complementary DNA (cDNA) was isolated from a pcD cDNA library prepared from C3H mouse fibroblast cell line polyadenylated RNA. Sequence analysis of 6...
- Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budF Bladt
Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
Nature 376:768-71. 1995..Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and ..
- Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brainW Jung
Institute of Pathology, University Hospital, Mainz, Germany
J Cell Biol 126:485-94. 1994Hepatocyte growth factor-scatter factor (HGF-SF) is a pleiotropic cytokine with mito-, morpho-, and motogenic effects on a variety of epithelial and endothelial cells...
- The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cellsK M Weidner
Institute of Cell Biology, Tumor Research, University of Essen Medical School, Germany
J Cell Biol 121:145-54. 1993..Two types of SF/HGF receptors have recently been discovered in epithelial cells, the high affinity c-Met receptor tyrosine kinase, and low affinity/high capacity binding sites, which are probably located on heparan ..
- Pax3 modulates expression of the c-Met receptor during limb muscle developmentJ A Epstein
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Proc Natl Acad Sci U S A 93:4213-8. 1996..The tyrosine kinase receptor for hepatocyte growth factor/scatter factor encoded by the c-met protooncogene is also expressed in limb muscle progenitors and, like Pax-3, is required in the mouse for limb ..
- Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesisD A Rappolee
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Ill, USA
Circ Res 78:1028-36. 1996..b>HGF receptor mRNA is detected in the mesoderm of the headfold stage and persists in myocardial precursors of the ventricles ..
- Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch miceX M Yang
Molecular Oncology Group, Royal Victoria Hospital, Montreal, Quebec, Canada
Development 122:2163-71. 1996Hepatocyte growth factor/scatter factor (HGF/SF) stimulates proliferation, dissociation, migration and morphogenesis of cells in culture...
- Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle developmentF Maina
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
Cell 87:531-42. 1996Hepatocyte growth factor (HGF) and its receptor, the Met tyrosine kinase, are determinants of placenta, liver, and muscle development. Here, we show that Met function in vivo requires signaling via two carboxy-terminal tyrosines...
- A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiationS Anastasi
Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma La Sapienza, 00161 Roma, Italy
J Cell Biol 137:1057-68. 1997..To analyze the biological effects of HGF/SF receptor activation, we stably expressed the constitutively activated receptor catalytic domain (p65(tpr-met)) in C2 ..
- Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limbD Mennerich
Department of Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany
Mech Dev 73:147-58. 1998..We show that induction of epithelial to mesenchymal transition of Pax-3-positive cells by SF/HGF was not sufficient to induce ectopic lbx-1 expression at the inter-limb level, while ectopic limb formation was ..
- The role of SF/HGF and c-Met in the development of skeletal muscleS Dietrich
King s College, London Bridge, London SE1 9RT, UK de
Development 126:1621-9. 1999..Previous work shows that the formation of migratory precursors requires the c-Met and SF/HGF genes...
- The role of Lbx1 in migration of muscle precursor cellsH Brohmann
Max Delbruck Centre for Molecular Medicine, Robert Rossle Strasse 10, Germany
Development 127:437-45. 2000..We suggest that Lbx1 controls the expression of genes that are essential for the recognition or interpretation of cues that guide migrating muscle precursors and maintain their migratory potential...
- A mechanism of cell survival: sequestration of Fas by the HGF receptor MetXue Wang
Department of Pathology, Division of Cellular and Molecular Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Mol Cell 9:411-21. 2002..Here, we report the discovery of a cell survival mechanism by which Met, a growth factor receptor tyrosine kinase, directly binds to and sequesters the death receptor Fas in hepatocytes...
- Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repairChang Goo Huh
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4262, Building 37, Room 4146A, Bethesda, MD 20892 4262, USA
Proc Natl Acad Sci U S A 101:4477-82. 2004..Because homozygous null mice for either hgf/sf or c-met die in utero, we used Cre/loxP-mediated gene targeting to investigate the function of c-met ..
- Met provides essential signals for liver regenerationMalgorzata Borowiak
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
Proc Natl Acad Sci U S A 101:10608-13. 2004..a crucial role of the Met tyrosine kinase receptor and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver, muscle, and placenta...
- Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavageDavid Tulasne
CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
Mol Cell Biol 24:10328-39. 2004The MET tyrosine kinase, the receptor of hepatocyte growth factor-scatter factor (HGF/SF), is known to be essential for normal development and cell survival...
- Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant alleleCarrie Graveel
Laboratory of Molecular Oncology and Cytogenetics Program, Van Andel Research Institute, Grand Rapids, MI 49503, USA
Proc Natl Acad Sci U S A 101:17198-203. 2004Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers...
- Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell massJennifer Roccisana
Division of Endocrinology, BST E 1140, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15261, USA
Diabetes 54:2090-102. 2005Overexpression of hepatocyte growth factor (HGF) in the beta-cell of transgenic mice enhances beta-cell proliferation, survival, and function...
- Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intoleranceChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Am J Pathol 167:429-36. 2005Hepatocyte growth factor (HGF) and its c-met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic beta-cell survival, proliferation, and function...
- Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotypePal Kaposi-Novak
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 116:1582-95. 2006..Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis...
- Loss of embryonic MET signaling alters profiles of hippocampal interneuronsGabriela J Martins
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Dev Neurosci 29:143-58. 2007..dorsally in response to cues, including hepatocyte growth factor/scatter factor which signals via its receptor MET. Examination of the hippocampus in adult mice in which MET had been inactivated in the embryonic proliferative ..
- Conditional activation of MET in differentiated skeletal muscle induces atrophyTiziana Crepaldi
Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
J Biol Chem 282:6812-22. 2007..Here we examined the effects of inducing expression of an oncogenic version of the Met receptor (Tpr-Met) in terminally differentiated skeletal muscle...
- Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migrationPaolo Giacobini
Department of Human and Animal Biology, University of Torino, 10123 Torino, Italy
J Neurosci 27:431-45. 2007..In this study, the role of HGF and its receptor Met during development of the GnRH-1 system was examined...
- c-Met is essential for wound healing in the skinJolanta Chmielowiec
Department of Cancer Biology, Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
J Cell Biol 177:151-62. 2007..We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre ..
- Regulation of c-met expression by transcription repressor DaxxV M Morozov
Department of Anatomy and Cell Biology and Shands Cancer Center, University of Florida, Gainesville, FL, USA
Oncogene 27:2177-86. 2008The protooncogene c-met encodes the tyrosine kinase receptor for the hepatocyte growth factor/scatter factor (HGF/SF). While overexpression of c-met is documented in many types of tumors, the mechanism of c-met regulation remains elusive...
- Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosisLuis E Gomez-Quiroz
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
J Biol Chem 283:14581-9. 2008The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction pathway that controls cell survival...
- Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitroGaelle del Castillo
Department Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s n, 28040 Madrid, Spain
Am J Pathol 172:1238-47. 2008The hepatocyte growth factor (HGF)/Met signaling system is essential for liver development, homeostasis, and function...
- Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphologyShuta Ishibe
Section of Nephrology, Yale University School of Medicine, New Haven, CT 06510, USA
Development 136:337-45. 2009..Although hepatocyte growth factor and its receptor Met have been shown to stimulate branching morphogenesis in explanted embryonic kidneys, loss of Met expression is ..
- Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrainMatthew C Judson
Graduate Program in Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
J Comp Neurol 513:511-31. 2009..proliferation, migration, differentiation, and survival-all of which can be mediated by hepatocyte growth factor (HGF) signaling through the Met receptor tyrosine kinase...
- Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancerCarrie R Graveel
Department of Molecular Oncology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
Proc Natl Acad Sci U S A 106:12909-14. 2009..The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer ..
- Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstructionHong Ma
Yale University School of Medicine, New Haven, Connecticut 06510, USA
Kidney Int 76:868-76. 2009Hepatocyte growth factor and its receptor, Met, activate biological pathways necessary for repair and regeneration following kidney injury...
- Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuriaChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Kidney Int 77:962-73. 2010..role in podocyte homeostasis, injury, and repair in vivo, we generated conditional knockout mice in which the HGF receptor, c-met, was specifically deleted in podocytes using the Cre-LoxP system...
- Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1Tiziana deAngelis
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Physiol 224:658-63. 2010The insulin receptor substrate-1 (IRS-1) and c-met, the receptor for the hepatocyte growth factor (HGF) co-immuno-precipitate from lysates treated with the respective antibodies...
- Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrainMatthew C Judson
Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
J Comp Neurol 518:4463-78. 2010Human genetic findings and murine neuroanatomical expression mapping have intersected to implicate Met receptor tyrosine kinase signaling in the development of forebrain circuits controlling social and emotional behaviors that are ..
- Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetesJose Mellado-Gil
Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Diabetes 60:525-36. 2011To determine the role of hepatocyte growth factor (HGF)/c-Met on β-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro.
- Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseasesGina M Coudriet
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e15384. 2010..These changes were a direct result of signaling through the HGF receptor, MET, as effects were reversed in the presence of a selective inhibitor of MET (SU11274) or when using BMM from ..
- Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivoLars Tönges
Department of Neurology, University Medicine Gottingen, R Koch Strasse 40, Gottingen, Germany
J Neurochem 117:892-903. 2011..Together with its corresponding receptor c-mesenchymal-epithelial transition factor (Met), it is expressed in the developing and the adult murine, rat and human CNS...
- Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitusCem Demirci
Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Diabetes 61:1143-52. 2012Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the β-cell. However, whether HGF/c-Met has a role in maternal β-cell adaptation during pregnancy is unknown...
- Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanismsTiago G Araújo
Department of Internal Medicine, State University of Campinas, Campinas, 13081 970 São Paulo, Brazil
Endocrinology 153:5760-9. 2012..Additionally, blockages of HGF receptor (Met) worsen the impaired insulin-induced insulin signaling in liver of diet-induced obesity rats...
- Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephrosA S Woolf
Units of Developmental Biology and Medicine, Institute of Child Health, London, United Kingdom
J Cell Biol 128:171-84. 1995..We investigated the role of HGF/SF and its membrane receptor, the product of the c-met protooncogene, in the early development of the metanephric kidney...
- Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesisHiroaki Yamamoto
Department of Medicine and Lung Biology Center, University of California, San Francisco, CA 94143, USA
Dev Biol 308:44-53. 2007..Lung endothelial cells express Hgf, and selective deletion of the Hgf receptor gene in respiratory epithelium phenocopies the malformation of septae, confirming the requirement for ..
- Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse developmentE Sonnenberg
Max Delbrück Laboratorium, Max Planck Gesellschaft, Koln, Germany
J Cell Biol 123:223-35. 1993Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro...
- Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neuronsA Ebens
Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
Neuron 17:1157-72. 1996..chemoattractant as hepatocyte growth factor/scatter factor (HGF/SF), a diffusible ligand for the c-Met receptor tyrosine kinase, and we also implicate HGF/SF at later stages as a muscle-derived survival factor for ..
- Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3Alexander Cramer
Institute of Biochemistry I, Friedrich Schiller University Jena, Nonnenplan 2, 07743 Jena, Germany
J Cell Biochem 95:805-16. 2005c-Met is the receptor for hepatocyte growth factor/scatter factor (HGF/SF)...
- Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent mannerAnice Moumen
Developmental Biology Institute of Marseille Luminy IBDML UMR 6216, CNRS Univ de la Mediterranée, Marseille, France
Hepatology 45:1210-7. 2007..Although hepatocyte growth factor (HGF) and its receptor Met are known to mediate cell survival in developing livers, the molecular mechanisms involved in this process are ..
- Mechanism of met oncogene activationM Park
Cell 45:895-904. 1986The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell line with N-methyl-N'-nitronitrosoguanidine (MNNG) is related to the tyrosine kinase gene family...
- Characterization of the mouse met proto-oncogeneA M Chan
Chemical Carcinogenesis Section, Chester Beatty Laboratories, London, UK
Oncogene 2:593-9. 1988The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor...
- Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strainsJ E Grisel
Research Service, Veterans Affairs Medical Center, Portland, OR 97201, USA
J Neurosci 17:745-54. 1997..In several instances, QTLs appeared to overlap, which is consistent with idea that common neural substrates underlie some responses to psychostimulants...
- Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cellsXianghong Zhang
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 288:F16-26. 2005Hepatocyte growth factor (HGF) receptor is a transmembrane receptor tyrosine kinase encoded by the c-met protooncogene. In this study, we demonstrated that c-met expression was upregulated in the kidney after obstructive injury in mice...
- Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathwaysTanja Bosse
Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, D 38124, Braunschweig, Germany
Mol Cell Biol 27:6615-28. 2007Activation of c-Met, the hepatocyte growth factor (HGF)/scatter factor receptor induces reorganization of the actin cytoskeleton, which drives epithelial cell scattering and motility and is exploited by pathogenic Listeria monocytogenes ..
- Distinct pathways of genomic progression to benign and malignant tumors of the liverAaron D Tward
G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:14771-6. 2007..We initiated tumorigenesis with a transgene of the protooncogene MET or by hydrodynamic transfection of MET in combination with other genes into the livers of adult animals...
- Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesisTaro Takami
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4262, USA
Cancer Res 67:9844-51. 2007..Here, we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis...
- Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALSKeiichi Kadoyama
Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
Neurosci Res 65:194-200. 2009..This study was designed to assess disease-dependent regulatory mechanisms of c-Met/HGF receptor (c-Met) activation in the facial motoneurons of G93A mice...
- Genetic disruption of Met signaling impairs GABAergic striatal development and cognitionG J Martins
Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
Neuroscience 176:199-209. 2011..of the striatal neurons and their assembly into functional circuits, we used a mouse with a targeted conditional Met mutation in post-mitotic cells of the ventral telencephalon...
- Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancerS Gastaldi
Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
Oncogene 32:1428-40. 2013..models, we found that luminal progenitors express high levels of the Met receptor for hepatocyte growth factor (HGF), as compared with the other mammary epithelial sub-populations...
- MET expression in melanoma correlates with a lymphangiogenic phenotypeAlexander Swoboda
Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Währingergürtel 18 20, Vienna 1090, Austria
Hum Mol Genet 21:3387-96. 2012..of vascular endothelial growth factor C (VEGF-C) and platelet derived growth factor C (PDGF-C) as well as of the met proto-oncogene (MET) and its targets to be associated with this lymphangiogenic phenotype...
- Met activation is required for early cytoprotection after ischemic kidney injurySherene Mason
Section of Nephrology, Department of Pediatrics
J Am Soc Nephrol 25:329-37. 2014Renal proximal tubule epithelial cells express high levels of the hepatocyte growth factor receptor Met, and both the receptor and ligand are upregulated after ischemic injury...
- Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma miceXiao Ping Chen
Department of Obstetrics and Gynecology, Yancheng City First People s Hospital, Yancheng, 215006, China
Mol Biol Rep 41:1247-56. 2014..reaction were applied to examine postive expression levels of Bcl-2, Bax and Caspase-3, HGF, MACC1, Caspase-3 and C-met proteins and MACC1 mRNA expression in tumour of CC mice...
- Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene METMatthew C Judson
Graduate Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37203, USA
Cereb Cortex 21:1613-26. 2011b>Met receptor tyrosine kinase signaling regulates the growth and development of axons and may contribute to the wiring of cortical and limbic circuits in the rodent forebrain...
- Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METHector Peinado
Children s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA
Nat Med 18:883-91. 2012..behavior of primary tumors by permanently 'educating' bone marrow progenitors through the receptor tyrosine kinase MET. Melanoma-derived exosomes also induced vascular leakiness at pre-metastatic sites and reprogrammed bone marrow ..
- c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney diseaseShan Qin
Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
J Am Soc Nephrol 23:1309-18. 2012..Hyperactivation of the tyrosine kinase c-Met contributes to cyst formation, but we do not know the downstream mediators...
- Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expressionBenjamin Otto
Department of Clinical Chemistry Central Laboratories, Center for Diagnostic, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int J Cancer 132:1300-10. 2013..The high-grade tumors are clearly separated from the low-grade tumors by strong expression of the Met gene and by coexpression of epithelial (e.g. keratin 18) and mesenchymal (e.g. vimentin) markers...
- Expression and chromosome localization of the murine cystic fibrosis transmembrane conductance regulatorK A Kelley
Mount Sinai School of Medicine, Arthur M Fishberg Research Center for Neurobiology, New York, New York 10029
Genomics 13:381-8. 1992..typing of the progeny of an interspecies backcross revealed that Cftr is closely linked to the proto-oncogene c-met locus (Met) in the centromeric region of mouse Chr 6, consistent with the observation that there is a conserved ..
- Localization of the cystic fibrosis transmembrane conductance regulator (Cftr) to mouse chromosome 6D Siegel
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021
Cytogenet Cell Genet 61:184-5. 1992
- The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6N G Irving
Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, UK
Cytogenet Cell Genet 50:121-2. 1989..both somatic cell hybrid analysis and genetic linkage analysis, in an interspecific Mus domesticus x Mus spretus cross that Cola-2 fails to cosegregate with mouse chromosome 16, but is linked to the Met proto-oncogene on chromosome 6.
- Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory siteC C Lee
Laboratory of Developmental Biology, NIDR, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 269:19457-61. 1994..a novel type of structural variant of the tyrosine kinase receptor for c-met, also known as the hepatocyte growth factor receptor, in mouse tissues...
- Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutationN Bahary
Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
Mamm Genome 4:511-5. 1993In a previous report, the ob mutation was mapped to a position 5 cM distal to Met on murine Chromosome (Chr) 6 in tight linkage to Cpa...
- Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomesJ Santos
Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
Cytogenet Cell Genet 62:217-9. 1993DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
- Expression of the met/hepatocyte growth factor/scatter factor receptor and its ligand during differentiation of murine P19 embryonal carcinoma cellsX M Yang
Department of Oncology, Royal Victoria Hospital, Montreal, Quebec, Canada
Dev Biol 157:308-20. 1993..From Northern hybridization studies the met/HGF/SF receptor (R) is expressed in many adult and embryonic mouse tissues...
- Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory systemD P Thewke
Neuroscience Program and Department of Biochemistry Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 16:6933-44. 1996The expression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the c-met proto-oncogene product, was examined by in situ hybridization in the developing and adult murine olfactory system and compared with the ..
- Multiple roles for hepatocyte growth factor in sympathetic neuron developmentF Maina
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
Neuron 20:835-46. 1998..These in vitro effects of anti-HGF antibodies and HGF were abolished by a disabling mutation of Met, the HGF receptor tyrosine kinase. The Met mutation also increased sympathetic neuroblast apoptosis in vivo...
- Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte developmentL Kos
Laboratory for Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
Pigment Cell Res 12:13-21. 1999..Hepatocyte growth factor/scatter factor (HGF/SF) signaling through the tyrosine-kinase receptor, MET, is capable of promoting the proliferation, increasing the ..
- Lbx1 is required for muscle precursor migration along a lateral pathway into the limbM K Gross
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Development 127:413-24. 2000..Previous studies have shown that Pax3, together with the c-Met receptor tyrosine kinase and its ligand Scatter Factor (SF) are necessary for the migration of hypaxial muscle ..
- Hepatocyte migration during liver development requires Prox1B Sosa-Pineda
Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Nat Genet 25:254-5. 2000..Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane...
- Essential role of Gab1 for signaling by the c-Met receptor in vivoM Sachs
Department of Growth and Differentiation, Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
J Cell Biol 150:1375-84. 2000..Thus, extensive similarities between the phenotypes of c-Met and HGF/SF mutant mice exist, and the muscle migration phenotype is even more pronounced in Gab1-/-:c-Met+/- embryos...
- Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic miceR Wang
G W Hooper Foundation and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
J Cell Biol 153:1023-34. 2001..Here we show that overexpression of the Met RTK allows activation of the receptor by cell attachment and that this form of activation can be tumorigenic...
- Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryosOsamu Amano
Department of Histology and Embryology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
Dev Dyn 223:169-79. 2002..cells of the first branchial arch at the 10th day of gestation (E10), before tongue formation, whereas HGF receptor (c-Met) -positive myogenic cells first appeared at E11 in the center of mandibles...
- Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesisLisa S Lock
Department of Biochemistry, Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada H3A 1A1
Mol Biol Cell 13:2132-46. 2002..Gab1 acts to diversify the signal downstream from the Met receptor tyrosine kinase through the recruitment of multiple signaling proteins, and is essential for epithelial ..
- Elevated C-met in thymic dendritic cells of New Zealand Black miceTomoyuki Okada
Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, 95616, USA
Dev Immunol 9:29-34. 2002..We report herein that NZB mice have a significant upregulation of C-met compared to the control strains. The abnormality of the C-met transcription was confined to thymic DC...
- Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary glandTatsuya Ikari
Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
Dev Dyn 228:173-84. 2003..5. Real-time reverse transcriptase-polymerase chain reaction showed that the expression of the c-met/HGF receptor gene in SMG increased and peaked between E14 and E16...
- Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung developmentVladimir V Kalinichenko
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 286:L521-30. 2004..Embryonic Foxf1(+/-) lungs exhibited diminished expression of hepatocyte growth factor receptor c-Met, myosin VI, the transcription factors SP-3, BMI-1, ATF-2, and glucocorticoid receptor, and ..
- The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivoFrederic Relaix
CNRS URA 2375, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
Genes Dev 17:2950-65. 2003..overexpression of c-met, leading to constitutive activation of Met signaling, despite the absence of the ligand SF/HGF. Haploinsufficiency of c-met rescues this phenotype, confirming the direct genetic link with Pax3...
- Divergent functions of murine Pax3 and Pax7 in limb muscle developmentFrederic Relaix
Centre National de la Recherche Scientifique CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
Genes Dev 18:1088-105. 2004..to defects in delamination, migration, and proliferation of muscle precursor cells with inefficient activation of c-met in the hypaxial domain of the somite. Despite this, overall muscle patterning is retained...
- The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasionJun Chung
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 279:32287-93. 2004..the alpha(6)beta(4) integrin exists on the surface of invasive carcinoma cells and that hepatocyte growth factor (HGF)-mediated invasion is dependent on alpha(6)beta(4) (Trusolino, L., Bertotti, A., and Comoglio, P. M...
- MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of metToshio Higuchi
Central Pharmaceutical Research Institute, Pharmaceutical Frontier Research Laboratories, Japan Tobacco Inc, Yokohama, 236 0004, Japan
Mol Cell Biol 24:7456-68. 2004..We demonstrate here that the C terminus of MUC20 associates with the multifunctional docking site of Met without ligand activation, preventing Grb2 recruitment to Met and thus attenuating hepatocyte growth factor (HGF)-..
- Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesisDaniela Zaffaroni
Department of Experimental Oncology, Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
Oncogene 24:1084-90. 2005Analysis of seven candidate genes mapping in the 1-Mb region of the mouse pulmonary adenoma resistance 4 (Par4) locus revealed a single amino-acid change, consisting in a nonconservative Arg968Cys variation in the juxtamembrane domain of ..
- A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axisMichael Rosu-Myles
Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
J Cell Sci 118:4343-52. 2005..antibody, but could be reduced by addition of c-met-blocking antibody and augmented by hepatocyte growth factor (HGF), the putative ligand for c-met...
- The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residuesSeth L Masters
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Victoria, Australia
Nat Struct Mol Biol 13:77-84. 2006..loop regions identified conserved structural determinants for its interaction with Par-4 and the hepatocyte growth factor receptor, c-Met...
- Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase MetElles M J Boon
Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Cancer Sci 97:710-5. 2006The receptor tyrosine kinase MET is overexpressed in human colorectal adenomas and carcinomas, suggesting an instrumental role for MET signaling in the onset and progression of colorectal cancer...
- A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limbLola Bajard
Centre National de la Recherche Scientifique URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
Genes Dev 20:2450-64. 2006..Mutation of the Pax3 site abolishes all expression controlled by the 145-bp sequence in transgenic mouse embryos. We conclude that Pax3 directly regulates Myf5 in the hypaxial somite and its derivatives...
- Met acts on Mdm2 via mTOR to signal cell survival during developmentAnice Moumen
Developmental Biology Institute of Marseille Luminy IBDML CNRS INSERM Université de la Méditerrannée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Development 134:1443-51. 2007..Inhibition of either mTOR or Mdm2 is sufficient to block cell survival induced by Hgf-Met in vitro...
- Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with agingWeiping Su
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 158th Avenue, Beaverton, OR 97006, USA
Glia 55:723-33. 2007..In light of our previous finding that aberrant expression of the MET receptor tyrosine kinase contributes to the invasiveness of human NF1-associated malignant peripheral nerve sheath ..
- Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinaseNing Li
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1074, USA
J Biol Chem 282:16764-75. 2007..These results indicate that the ubiquitin ligase activity of Cbl is critical for clathrin-dependent cMet internalization and suggest a role for Grb2 as an intermediary linking Cbl ubiquitin ligase activity to this process...
- CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactinPatrick A Singleton
Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 282:30643-57. 2007..In this study, we explored the regulation of hepatocyte growth factor (HGF)-mediated enhancement of EC barrier function via CD44 isoforms...
- Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-cateninDavid A Hutcheson
Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
Genes Dev 23:997-1013. 2009..Together, these studies demonstrate that limb embryonic and fetal myogenic cells develop from distinct, but related progenitors and have different cell-autonomous requirements for beta-catenin...
- The autism risk genes MET and PLAUR differentially impact cortical developmentKathie L Eagleson
Zilkha Neurogenetic Institute, Keck School of Medicine at USC, Los Angeles, California 90033, USA
Autism Res 4:68-83. 2011..We previously identified two ASD risk genes encoding the receptor tyrosine kinase MET and the urokinase plasminogen activator receptor (PLAUR), which is thought to modulate availability of the MET ..
- Involvement of hepatocyte growth factor in kidney developmentO F Santos
Harvard Medical School, Boston, Massachusetts 02115
Dev Biol 163:525-9. 1994Using PCR, hepatocyte growth factor (HGF) and c-met (HGF receptor) expression were analyzed in the developing mouse kidney. Both HGF and c-met were expressed from Gestational Day 11...
- Early specification of limb muscle precursor cells by the homeobox gene Lbx1hK Schafer
Institute of Physiological Chemistry, Martin Luther University Halle, 06097 Halle, Hollystr 1, Germany
Nat Genet 23:213-6. 1999..Regulatory molecules such as receptor tyrosine kinases like c-Met ( ref. 6) and those encoded by homeobox-containing genes, including c-Met (ref. 6), Tbx1 (ref. 7), Mox2 (ref...
- Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regenerationD D Cornelison
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Dev Biol 239:79-94. 2001..Data from cell culture and in vivo experiments implicate both FGFs and HGF as critical regulators of these processes...
- Examination of activating Met mutations in tumorigenesisCarrie Graveel; Fiscal Year: 2007The overall objective of this study is to determine whether activating mutations near the Met tyrosine kinase domain are tumorigenic due to altered substrate specificity and the activation of distinct signaling pathways...