Met

Summary

Gene Symbol: Met
Description: met proto-oncogene
Alias: AI838057, HGF, HGFR, Par4, c-Met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, met proto-oncogene tyrosine kinase, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met
Species: mouse

Top Publications

  1. ncbi Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse
    G Daston
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 122:1017-27. 1996
  2. pmc Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor
    S Rong
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Mol Cell Biol 12:5152-8. 1992
  3. ncbi Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene
    A Iyer
    Rush Presbyterian St Luke s Medical Center, Medical Oncology Department, Chicago, Illinois 60612
    Cell Growth Differ 1:87-95. 1990
  4. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
  5. pmc Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain
    W Jung
    Institute of Pathology, University Hospital, Mainz, Germany
    J Cell Biol 126:485-94. 1994
  6. pmc The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells
    K M Weidner
    Institute of Cell Biology, Tumor Research, University of Essen Medical School, Germany
    J Cell Biol 121:145-54. 1993
  7. pmc Pax3 modulates expression of the c-Met receptor during limb muscle development
    J A Epstein
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 93:4213-8. 1996
  8. ncbi Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis
    D A Rappolee
    Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Ill, USA
    Circ Res 78:1028-36. 1996
  9. ncbi Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice
    X M Yang
    Molecular Oncology Group, Royal Victoria Hospital, Montreal, Quebec, Canada
    Development 122:2163-71. 1996
  10. ncbi Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development
    F Maina
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 87:531-42. 1996

Research Grants

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse
    G Daston
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 122:1017-27. 1996
    ..The failure of limb muscle precursors to invade the limb in splotch mice is associated with the absence of c-met expression in premigratory cells, together with a change in the morphology of the ventral dermomyotome...
  2. pmc Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor
    S Rong
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Mol Cell Biol 12:5152-8. 1992
    The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells...
  3. ncbi Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene
    A Iyer
    Rush Presbyterian St Luke s Medical Center, Medical Oncology Department, Chicago, Illinois 60612
    Cell Growth Differ 1:87-95. 1990
    A 6.7-kilobase met complementary DNA (cDNA) was isolated from a pcD cDNA library prepared from C3H mouse fibroblast cell line polyadenylated RNA. Sequence analysis of 6...
  4. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
    ..Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and ..
  5. pmc Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain
    W Jung
    Institute of Pathology, University Hospital, Mainz, Germany
    J Cell Biol 126:485-94. 1994
    Hepatocyte growth factor-scatter factor (HGF-SF) is a pleiotropic cytokine with mito-, morpho-, and motogenic effects on a variety of epithelial and endothelial cells...
  6. pmc The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells
    K M Weidner
    Institute of Cell Biology, Tumor Research, University of Essen Medical School, Germany
    J Cell Biol 121:145-54. 1993
    ..Two types of SF/HGF receptors have recently been discovered in epithelial cells, the high affinity c-Met receptor tyrosine kinase, and low affinity/high capacity binding sites, which are probably located on heparan ..
  7. pmc Pax3 modulates expression of the c-Met receptor during limb muscle development
    J A Epstein
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 93:4213-8. 1996
    ..The tyrosine kinase receptor for hepatocyte growth factor/scatter factor encoded by the c-met protooncogene is also expressed in limb muscle progenitors and, like Pax-3, is required in the mouse for limb ..
  8. ncbi Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis
    D A Rappolee
    Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Ill, USA
    Circ Res 78:1028-36. 1996
    ..b>HGF receptor mRNA is detected in the mesoderm of the headfold stage and persists in myocardial precursors of the ventricles ..
  9. ncbi Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice
    X M Yang
    Molecular Oncology Group, Royal Victoria Hospital, Montreal, Quebec, Canada
    Development 122:2163-71. 1996
    Hepatocyte growth factor/scatter factor (HGF/SF) stimulates proliferation, dissociation, migration and morphogenesis of cells in culture...
  10. ncbi Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development
    F Maina
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 87:531-42. 1996
    Hepatocyte growth factor (HGF) and its receptor, the Met tyrosine kinase, are determinants of placenta, liver, and muscle development. Here, we show that Met function in vivo requires signaling via two carboxy-terminal tyrosines...
  11. pmc A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation
    S Anastasi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma La Sapienza, 00161 Roma, Italy
    J Cell Biol 137:1057-68. 1997
    ..To analyze the biological effects of HGF/SF receptor activation, we stably expressed the constitutively activated receptor catalytic domain (p65(tpr-met)) in C2 ..
  12. ncbi Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb
    D Mennerich
    Department of Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany
    Mech Dev 73:147-58. 1998
    ..We show that induction of epithelial to mesenchymal transition of Pax-3-positive cells by SF/HGF was not sufficient to induce ectopic lbx-1 expression at the inter-limb level, while ectopic limb formation was ..
  13. ncbi The role of SF/HGF and c-Met in the development of skeletal muscle
    S Dietrich
    King s College, London Bridge, London SE1 9RT, UK de
    Development 126:1621-9. 1999
    ..Previous work shows that the formation of migratory precursors requires the c-Met and SF/HGF genes...
  14. ncbi The role of Lbx1 in migration of muscle precursor cells
    H Brohmann
    Max Delbruck Centre for Molecular Medicine, Robert Rossle Strasse 10, Germany
    Development 127:437-45. 2000
    ..We suggest that Lbx1 controls the expression of genes that are essential for the recognition or interpretation of cues that guide migrating muscle precursors and maintain their migratory potential...
  15. ncbi A mechanism of cell survival: sequestration of Fas by the HGF receptor Met
    Xue Wang
    Department of Pathology, Division of Cellular and Molecular Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Cell 9:411-21. 2002
    ..Here, we report the discovery of a cell survival mechanism by which Met, a growth factor receptor tyrosine kinase, directly binds to and sequesters the death receptor Fas in hepatocytes...
  16. pmc Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    Chang Goo Huh
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4262, Building 37, Room 4146A, Bethesda, MD 20892 4262, USA
    Proc Natl Acad Sci U S A 101:4477-82. 2004
    ..Because homozygous null mice for either hgf/sf or c-met die in utero, we used Cre/loxP-mediated gene targeting to investigate the function of c-met ..
  17. pmc Met provides essential signals for liver regeneration
    Malgorzata Borowiak
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 101:10608-13. 2004
    ..a crucial role of the Met tyrosine kinase receptor and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver, muscle, and placenta...
  18. pmc Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage
    David Tulasne
    CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    Mol Cell Biol 24:10328-39. 2004
    The MET tyrosine kinase, the receptor of hepatocyte growth factor-scatter factor (HGF/SF), is known to be essential for normal development and cell survival...
  19. pmc Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele
    Carrie Graveel
    Laboratory of Molecular Oncology and Cytogenetics Program, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 101:17198-203. 2004
    Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers...
  20. ncbi Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass
    Jennifer Roccisana
    Division of Endocrinology, BST E 1140, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15261, USA
    Diabetes 54:2090-102. 2005
    Overexpression of hepatocyte growth factor (HGF) in the beta-cell of transgenic mice enhances beta-cell proliferation, survival, and function...
  21. pmc Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance
    Chunsun Dai
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Pathol 167:429-36. 2005
    Hepatocyte growth factor (HGF) and its c-met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic beta-cell survival, proliferation, and function...
  22. pmc Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    Pal Kaposi-Novak
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1582-95. 2006
    ..Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis...
  23. ncbi Loss of embryonic MET signaling alters profiles of hippocampal interneurons
    Gabriela J Martins
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Dev Neurosci 29:143-58. 2007
    ..dorsally in response to cues, including hepatocyte growth factor/scatter factor which signals via its receptor MET. Examination of the hippocampus in adult mice in which MET had been inactivated in the embryonic proliferative ..
  24. ncbi Conditional activation of MET in differentiated skeletal muscle induces atrophy
    Tiziana Crepaldi
    Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
    J Biol Chem 282:6812-22. 2007
    ..Here we examined the effects of inducing expression of an oncogenic version of the Met receptor (Tpr-Met) in terminally differentiated skeletal muscle...
  25. ncbi Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration
    Paolo Giacobini
    Department of Human and Animal Biology, University of Torino, 10123 Torino, Italy
    J Neurosci 27:431-45. 2007
    ..In this study, the role of HGF and its receptor Met during development of the GnRH-1 system was examined...
  26. pmc c-Met is essential for wound healing in the skin
    Jolanta Chmielowiec
    Department of Cancer Biology, Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 177:151-62. 2007
    ..We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre ..
  27. ncbi Regulation of c-met expression by transcription repressor Daxx
    V M Morozov
    Department of Anatomy and Cell Biology and Shands Cancer Center, University of Florida, Gainesville, FL, USA
    Oncogene 27:2177-86. 2008
    The protooncogene c-met encodes the tyrosine kinase receptor for the hepatocyte growth factor/scatter factor (HGF/SF). While overexpression of c-met is documented in many types of tumors, the mechanism of c-met regulation remains elusive...
  28. pmc Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis
    Luis E Gomez-Quiroz
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    J Biol Chem 283:14581-9. 2008
    The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction pathway that controls cell survival...
  29. pmc Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro
    Gaelle del Castillo
    Department Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s n, 28040 Madrid, Spain
    Am J Pathol 172:1238-47. 2008
    The hepatocyte growth factor (HGF)/Met signaling system is essential for liver development, homeostasis, and function...
  30. pmc Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology
    Shuta Ishibe
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06510, USA
    Development 136:337-45. 2009
    ..Although hepatocyte growth factor and its receptor Met have been shown to stimulate branching morphogenesis in explanted embryonic kidneys, loss of Met expression is ..
  31. pmc Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain
    Matthew C Judson
    Graduate Program in Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    J Comp Neurol 513:511-31. 2009
    ..proliferation, migration, differentiation, and survival-all of which can be mediated by hepatocyte growth factor (HGF) signaling through the Met receptor tyrosine kinase...
  32. pmc Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
    Carrie R Graveel
    Department of Molecular Oncology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 106:12909-14. 2009
    ..The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer ..
  33. doi Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction
    Hong Ma
    Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Kidney Int 76:868-76. 2009
    Hepatocyte growth factor and its receptor, Met, activate biological pathways necessary for repair and regeneration following kidney injury...
  34. pmc Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria
    Chunsun Dai
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 77:962-73. 2010
    ..role in podocyte homeostasis, injury, and repair in vivo, we generated conditional knockout mice in which the HGF receptor, c-met, was specifically deleted in podocytes using the Cre-LoxP system...
  35. doi Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1
    Tiziana deAngelis
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Physiol 224:658-63. 2010
    The insulin receptor substrate-1 (IRS-1) and c-met, the receptor for the hepatocyte growth factor (HGF) co-immuno-precipitate from lysates treated with the respective antibodies...
  36. pmc Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain
    Matthew C Judson
    Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    J Comp Neurol 518:4463-78. 2010
    Human genetic findings and murine neuroanatomical expression mapping have intersected to implicate Met receptor tyrosine kinase signaling in the development of forebrain circuits controlling social and emotional behaviors that are ..
  37. pmc Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes
    Jose Mellado-Gil
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:525-36. 2011
    To determine the role of hepatocyte growth factor (HGF)/c-Met on β-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro.
  38. pmc Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases
    Gina M Coudriet
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e15384. 2010
    ..These changes were a direct result of signaling through the HGF receptor, MET, as effects were reversed in the presence of a selective inhibitor of MET (SU11274) or when using BMM from ..
  39. doi Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo
    Lars Tönges
    Department of Neurology, University Medicine Gottingen, R Koch Strasse 40, Gottingen, Germany
    J Neurochem 117:892-903. 2011
    ..Together with its corresponding receptor c-mesenchymal-epithelial transition factor (Met), it is expressed in the developing and the adult murine, rat and human CNS...
  40. pmc Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus
    Cem Demirci
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 61:1143-52. 2012
    Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the β-cell. However, whether HGF/c-Met has a role in maternal β-cell adaptation during pregnancy is unknown...
  41. doi Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms
    Tiago G Araújo
    Department of Internal Medicine, State University of Campinas, Campinas, 13081 970 São Paulo, Brazil
    Endocrinology 153:5760-9. 2012
    ..Additionally, blockages of HGF receptor (Met) worsen the impaired insulin-induced insulin signaling in liver of diet-induced obesity rats...
  42. pmc Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
    A S Woolf
    Units of Developmental Biology and Medicine, Institute of Child Health, London, United Kingdom
    J Cell Biol 128:171-84. 1995
    ..We investigated the role of HGF/SF and its membrane receptor, the product of the c-met protooncogene, in the early development of the metanephric kidney...
  43. ncbi Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis
    Hiroaki Yamamoto
    Department of Medicine and Lung Biology Center, University of California, San Francisco, CA 94143, USA
    Dev Biol 308:44-53. 2007
    ..Lung endothelial cells express Hgf, and selective deletion of the Hgf receptor gene in respiratory epithelium phenocopies the malformation of septae, confirming the requirement for ..
  44. pmc Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
    E Sonnenberg
    Max Delbrück Laboratorium, Max Planck Gesellschaft, Koln, Germany
    J Cell Biol 123:223-35. 1993
    Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro...
  45. ncbi Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
    A Ebens
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Neuron 17:1157-72. 1996
    ..chemoattractant as hepatocyte growth factor/scatter factor (HGF/SF), a diffusible ligand for the c-Met receptor tyrosine kinase, and we also implicate HGF/SF at later stages as a muscle-derived survival factor for ..
  46. ncbi Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3
    Alexander Cramer
    Institute of Biochemistry I, Friedrich Schiller University Jena, Nonnenplan 2, 07743 Jena, Germany
    J Cell Biochem 95:805-16. 2005
    c-Met is the receptor for hepatocyte growth factor/scatter factor (HGF/SF)...
  47. ncbi Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner
    Anice Moumen
    Developmental Biology Institute of Marseille Luminy IBDML UMR 6216, CNRS Univ de la Mediterranée, Marseille, France
    Hepatology 45:1210-7. 2007
    ..Although hepatocyte growth factor (HGF) and its receptor Met are known to mediate cell survival in developing livers, the molecular mechanisms involved in this process are ..
  48. ncbi Mechanism of met oncogene activation
    M Park
    Cell 45:895-904. 1986
    The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell line with N-methyl-N'-nitronitrosoguanidine (MNNG) is related to the tyrosine kinase gene family...
  49. ncbi Characterization of the mouse met proto-oncogene
    A M Chan
    Chemical Carcinogenesis Section, Chester Beatty Laboratories, London, UK
    Oncogene 2:593-9. 1988
    The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor...
  50. ncbi Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains
    J E Grisel
    Research Service, Veterans Affairs Medical Center, Portland, OR 97201, USA
    J Neurosci 17:745-54. 1997
    ..In several instances, QTLs appeared to overlap, which is consistent with idea that common neural substrates underlie some responses to psychostimulants...
  51. ncbi Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells
    Xianghong Zhang
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 288:F16-26. 2005
    Hepatocyte growth factor (HGF) receptor is a transmembrane receptor tyrosine kinase encoded by the c-met protooncogene. In this study, we demonstrated that c-met expression was upregulated in the kidney after obstructive injury in mice...
  52. pmc Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways
    Tanja Bosse
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, D 38124, Braunschweig, Germany
    Mol Cell Biol 27:6615-28. 2007
    Activation of c-Met, the hepatocyte growth factor (HGF)/scatter factor receptor induces reorganization of the actin cytoskeleton, which drives epithelial cell scattering and motility and is exploited by pathogenic Listeria monocytogenes ..
  53. pmc Distinct pathways of genomic progression to benign and malignant tumors of the liver
    Aaron D Tward
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:14771-6. 2007
    ..We initiated tumorigenesis with a transgene of the protooncogene MET or by hydrodynamic transfection of MET in combination with other genes into the livers of adult animals...
  54. ncbi Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis
    Taro Takami
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4262, USA
    Cancer Res 67:9844-51. 2007
    ..Here, we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis...
  55. doi Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS
    Keiichi Kadoyama
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Neurosci Res 65:194-200. 2009
    ..This study was designed to assess disease-dependent regulatory mechanisms of c-Met/HGF receptor (c-Met) activation in the facial motoneurons of G93A mice...
  56. pmc Genetic disruption of Met signaling impairs GABAergic striatal development and cognition
    G J Martins
    Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Neuroscience 176:199-209. 2011
    ..of the striatal neurons and their assembly into functional circuits, we used a mouse with a targeted conditional Met mutation in post-mitotic cells of the ventral telencephalon...
  57. doi Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer
    S Gastaldi
    Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
    Oncogene 32:1428-40. 2013
    ..models, we found that luminal progenitors express high levels of the Met receptor for hepatocyte growth factor (HGF), as compared with the other mammary epithelial sub-populations...
  58. doi MET expression in melanoma correlates with a lymphangiogenic phenotype
    Alexander Swoboda
    Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Währingergürtel 18 20, Vienna 1090, Austria
    Hum Mol Genet 21:3387-96. 2012
    ..of vascular endothelial growth factor C (VEGF-C) and platelet derived growth factor C (PDGF-C) as well as of the met proto-oncogene (MET) and its targets to be associated with this lymphangiogenic phenotype...
  59. pmc Met activation is required for early cytoprotection after ischemic kidney injury
    Sherene Mason
    Section of Nephrology, Department of Pediatrics
    J Am Soc Nephrol 25:329-37. 2014
    Renal proximal tubule epithelial cells express high levels of the hepatocyte growth factor receptor Met, and both the receptor and ligand are upregulated after ischemic injury...
  60. doi Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice
    Xiao Ping Chen
    Department of Obstetrics and Gynecology, Yancheng City First People s Hospital, Yancheng, 215006, China
    Mol Biol Rep 41:1247-56. 2014
    ..reaction were applied to examine postive expression levels of Bcl-2, Bax and Caspase-3, HGF, MACC1, Caspase-3 and C-met proteins and MACC1 mRNA expression in tumour of CC mice...
  61. pmc Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene MET
    Matthew C Judson
    Graduate Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    Cereb Cortex 21:1613-26. 2011
    b>Met receptor tyrosine kinase signaling regulates the growth and development of axons and may contribute to the wiring of cortical and limbic circuits in the rodent forebrain...
  62. pmc Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    Hector Peinado
    Children s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA
    Nat Med 18:883-91. 2012
    ..behavior of primary tumors by permanently 'educating' bone marrow progenitors through the receptor tyrosine kinase MET. Melanoma-derived exosomes also induced vascular leakiness at pre-metastatic sites and reprogrammed bone marrow ..
  63. pmc c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease
    Shan Qin
    Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 23:1309-18. 2012
    ..Hyperactivation of the tyrosine kinase c-Met contributes to cyst formation, but we do not know the downstream mediators...
  64. doi Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
    Benjamin Otto
    Department of Clinical Chemistry Central Laboratories, Center for Diagnostic, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 132:1300-10. 2013
    ..The high-grade tumors are clearly separated from the low-grade tumors by strong expression of the Met gene and by coexpression of epithelial (e.g. keratin 18) and mesenchymal (e.g. vimentin) markers...
  65. ncbi Expression and chromosome localization of the murine cystic fibrosis transmembrane conductance regulator
    K A Kelley
    Mount Sinai School of Medicine, Arthur M Fishberg Research Center for Neurobiology, New York, New York 10029
    Genomics 13:381-8. 1992
    ..typing of the progeny of an interspecies backcross revealed that Cftr is closely linked to the proto-oncogene c-met locus (Met) in the centromeric region of mouse Chr 6, consistent with the observation that there is a conserved ..
  66. ncbi Localization of the cystic fibrosis transmembrane conductance regulator (Cftr) to mouse chromosome 6
    D Siegel
    Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021
    Cytogenet Cell Genet 61:184-5. 1992
  67. ncbi The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6
    N G Irving
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, UK
    Cytogenet Cell Genet 50:121-2. 1989
    ..both somatic cell hybrid analysis and genetic linkage analysis, in an interspecific Mus domesticus x Mus spretus cross that Cola-2 fails to cosegregate with mouse chromosome 16, but is linked to the Met proto-oncogene on chromosome 6.
  68. ncbi Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory site
    C C Lee
    Laboratory of Developmental Biology, NIDR, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:19457-61. 1994
    ..a novel type of structural variant of the tyrosine kinase receptor for c-met, also known as the hepatocyte growth factor receptor, in mouse tissues...
  69. ncbi Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation
    N Bahary
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
    Mamm Genome 4:511-5. 1993
    In a previous report, the ob mutation was mapped to a position 5 cM distal to Met on murine Chromosome (Chr) 6 in tight linkage to Cpa...
  70. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  71. ncbi Expression of the met/hepatocyte growth factor/scatter factor receptor and its ligand during differentiation of murine P19 embryonal carcinoma cells
    X M Yang
    Department of Oncology, Royal Victoria Hospital, Montreal, Quebec, Canada
    Dev Biol 157:308-20. 1993
    ..From Northern hybridization studies the met/HGF/SF receptor (R) is expressed in many adult and embryonic mouse tissues...
  72. ncbi Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system
    D P Thewke
    Neuroscience Program and Department of Biochemistry Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 16:6933-44. 1996
    The expression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the c-met proto-oncogene product, was examined by in situ hybridization in the developing and adult murine olfactory system and compared with the ..
  73. ncbi Multiple roles for hepatocyte growth factor in sympathetic neuron development
    F Maina
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Neuron 20:835-46. 1998
    ..These in vitro effects of anti-HGF antibodies and HGF were abolished by a disabling mutation of Met, the HGF receptor tyrosine kinase. The Met mutation also increased sympathetic neuroblast apoptosis in vivo...
  74. ncbi Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development
    L Kos
    Laboratory for Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
    Pigment Cell Res 12:13-21. 1999
    ..Hepatocyte growth factor/scatter factor (HGF/SF) signaling through the tyrosine-kinase receptor, MET, is capable of promoting the proliferation, increasing the ..
  75. ncbi Lbx1 is required for muscle precursor migration along a lateral pathway into the limb
    M K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 127:413-24. 2000
    ..Previous studies have shown that Pax3, together with the c-Met receptor tyrosine kinase and its ligand Scatter Factor (SF) are necessary for the migration of hypaxial muscle ..
  76. ncbi Hepatocyte migration during liver development requires Prox1
    B Sosa-Pineda
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 25:254-5. 2000
    ..Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane...
  77. pmc Essential role of Gab1 for signaling by the c-Met receptor in vivo
    M Sachs
    Department of Growth and Differentiation, Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    J Cell Biol 150:1375-84. 2000
    ..Thus, extensive similarities between the phenotypes of c-Met and HGF/SF mutant mice exist, and the muscle migration phenotype is even more pronounced in Gab1-/-:c-Met+/- embryos...
  78. pmc Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
    R Wang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 153:1023-34. 2001
    ..Here we show that overexpression of the Met RTK allows activation of the receptor by cell attachment and that this form of activation can be tumorigenic...
  79. ncbi Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos
    Osamu Amano
    Department of Histology and Embryology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Dev Dyn 223:169-79. 2002
    ..cells of the first branchial arch at the 10th day of gestation (E10), before tongue formation, whereas HGF receptor (c-Met) -positive myogenic cells first appeared at E11 in the center of mandibles...
  80. pmc Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis
    Lisa S Lock
    Department of Biochemistry, Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada H3A 1A1
    Mol Biol Cell 13:2132-46. 2002
    ..Gab1 acts to diversify the signal downstream from the Met receptor tyrosine kinase through the recruitment of multiple signaling proteins, and is essential for epithelial ..
  81. pmc Elevated C-met in thymic dendritic cells of New Zealand Black mice
    Tomoyuki Okada
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, 95616, USA
    Dev Immunol 9:29-34. 2002
    ..We report herein that NZB mice have a significant upregulation of C-met compared to the control strains. The abnormality of the C-met transcription was confined to thymic DC...
  82. ncbi Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland
    Tatsuya Ikari
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Dev Dyn 228:173-84. 2003
    ..5. Real-time reverse transcriptase-polymerase chain reaction showed that the expression of the c-met/HGF receptor gene in SMG increased and peaked between E14 and E16...
  83. ncbi Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development
    Vladimir V Kalinichenko
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL 60607 7170, USA
    Am J Physiol Lung Cell Mol Physiol 286:L521-30. 2004
    ..Embryonic Foxf1(+/-) lungs exhibited diminished expression of hepatocyte growth factor receptor c-Met, myosin VI, the transcription factors SP-3, BMI-1, ATF-2, and glucocorticoid receptor, and ..
  84. pmc The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo
    Frederic Relaix
    CNRS URA 2375, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 17:2950-65. 2003
    ..overexpression of c-met, leading to constitutive activation of Met signaling, despite the absence of the ligand SF/HGF. Haploinsufficiency of c-met rescues this phenotype, confirming the direct genetic link with Pax3...
  85. pmc Divergent functions of murine Pax3 and Pax7 in limb muscle development
    Frederic Relaix
    Centre National de la Recherche Scientifique CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 18:1088-105. 2004
    ..to defects in delamination, migration, and proliferation of muscle precursor cells with inefficient activation of c-met in the hypaxial domain of the somite. Despite this, overall muscle patterning is retained...
  86. ncbi The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
    ..the alpha(6)beta(4) integrin exists on the surface of invasive carcinoma cells and that hepatocyte growth factor (HGF)-mediated invasion is dependent on alpha(6)beta(4) (Trusolino, L., Bertotti, A., and Comoglio, P. M...
  87. pmc MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met
    Toshio Higuchi
    Central Pharmaceutical Research Institute, Pharmaceutical Frontier Research Laboratories, Japan Tobacco Inc, Yokohama, 236 0004, Japan
    Mol Cell Biol 24:7456-68. 2004
    ..We demonstrate here that the C terminus of MUC20 associates with the multifunctional docking site of Met without ligand activation, preventing Grb2 recruitment to Met and thus attenuating hepatocyte growth factor (HGF)-..
  88. ncbi Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis
    Daniela Zaffaroni
    Department of Experimental Oncology, Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
    Oncogene 24:1084-90. 2005
    Analysis of seven candidate genes mapping in the 1-Mb region of the mouse pulmonary adenoma resistance 4 (Par4) locus revealed a single amino-acid change, consisting in a nonconservative Arg968Cys variation in the juxtamembrane domain of ..
  89. ncbi A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis
    Michael Rosu-Myles
    Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    J Cell Sci 118:4343-52. 2005
    ..antibody, but could be reduced by addition of c-met-blocking antibody and augmented by hepatocyte growth factor (HGF), the putative ligand for c-met...
  90. ncbi The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Victoria, Australia
    Nat Struct Mol Biol 13:77-84. 2006
    ..loop regions identified conserved structural determinants for its interaction with Par-4 and the hepatocyte growth factor receptor, c-Met...
  91. ncbi Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met
    Elles M J Boon
    Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cancer Sci 97:710-5. 2006
    The receptor tyrosine kinase MET is overexpressed in human colorectal adenomas and carcinomas, suggesting an instrumental role for MET signaling in the onset and progression of colorectal cancer...
  92. pmc A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb
    Lola Bajard
    Centre National de la Recherche Scientifique URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 20:2450-64. 2006
    ..Mutation of the Pax3 site abolishes all expression controlled by the 145-bp sequence in transgenic mouse embryos. We conclude that Pax3 directly regulates Myf5 in the hypaxial somite and its derivatives...
  93. ncbi Met acts on Mdm2 via mTOR to signal cell survival during development
    Anice Moumen
    Developmental Biology Institute of Marseille Luminy IBDML CNRS INSERM Université de la Méditerrannée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Development 134:1443-51. 2007
    ..Inhibition of either mTOR or Mdm2 is sufficient to block cell survival induced by Hgf-Met in vitro...
  94. ncbi Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging
    Weiping Su
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 158th Avenue, Beaverton, OR 97006, USA
    Glia 55:723-33. 2007
    ..In light of our previous finding that aberrant expression of the MET receptor tyrosine kinase contributes to the invasiveness of human NF1-associated malignant peripheral nerve sheath ..
  95. ncbi Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase
    Ning Li
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1074, USA
    J Biol Chem 282:16764-75. 2007
    ..These results indicate that the ubiquitin ligase activity of Cbl is critical for clathrin-dependent cMet internalization and suggest a role for Grb2 as an intermediary linking Cbl ubiquitin ligase activity to this process...
  96. ncbi CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:30643-57. 2007
    ..In this study, we explored the regulation of hepatocyte growth factor (HGF)-mediated enhancement of EC barrier function via CD44 isoforms...
  97. pmc Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin
    David A Hutcheson
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 23:997-1013. 2009
    ..Together, these studies demonstrate that limb embryonic and fetal myogenic cells develop from distinct, but related progenitors and have different cell-autonomous requirements for beta-catenin...
  98. pmc The autism risk genes MET and PLAUR differentially impact cortical development
    Kathie L Eagleson
    Zilkha Neurogenetic Institute, Keck School of Medicine at USC, Los Angeles, California 90033, USA
    Autism Res 4:68-83. 2011
    ..We previously identified two ASD risk genes encoding the receptor tyrosine kinase MET and the urokinase plasminogen activator receptor (PLAUR), which is thought to modulate availability of the MET ..
  99. ncbi Involvement of hepatocyte growth factor in kidney development
    O F Santos
    Harvard Medical School, Boston, Massachusetts 02115
    Dev Biol 163:525-9. 1994
    Using PCR, hepatocyte growth factor (HGF) and c-met (HGF receptor) expression were analyzed in the developing mouse kidney. Both HGF and c-met were expressed from Gestational Day 11...
  100. ncbi Early specification of limb muscle precursor cells by the homeobox gene Lbx1h
    K Schafer
    Institute of Physiological Chemistry, Martin Luther University Halle, 06097 Halle, Hollystr 1, Germany
    Nat Genet 23:213-6. 1999
    ..Regulatory molecules such as receptor tyrosine kinases like c-Met ( ref. 6) and those encoded by homeobox-containing genes, including c-Met (ref. 6), Tbx1 (ref. 7), Mox2 (ref...
  101. ncbi Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration
    D D Cornelison
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Dev Biol 239:79-94. 2001
    ..Data from cell culture and in vivo experiments implicate both FGFs and HGF as critical regulators of these processes...

Research Grants1

  1. Examination of activating Met mutations in tumorigenesis
    Carrie Graveel; Fiscal Year: 2007
    The overall objective of this study is to determine whether activating mutations near the Met tyrosine kinase domain are tumorigenic due to altered substrate specificity and the activation of distinct signaling pathways...