Mef2a

Summary

Gene Symbol: Mef2a
Description: myocyte enhancer factor 2A
Alias: A430079H05Rik, myocyte-specific enhancer factor 2A
Species: mouse

Top Publications

  1. ncbi Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo
    David L Allen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    J Biol Chem 280:17126-34. 2005
  2. ncbi A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 311:1012-7. 2006
  3. ncbi Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Development 120:1251-63. 1994
  4. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
  5. ncbi Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
    G E Lyons
    Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA
    J Neurosci 15:5727-38. 1995
  6. pmc Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 117:2459-67. 2007
  7. pmc Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2
    Brad E Pfeiffer
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 66:191-7. 2010
  8. ncbi Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor
    Francisco J Naya
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Med 8:1303-9. 2002
  9. ncbi The expression of MEF2 genes is implicated in CNS neuronal differentiation
    X Lin
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore 21201, USA
    Brain Res Mol Brain Res 42:307-16. 1996
  10. pmc In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival
    M Waseem Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e34863. 2012

Research Grants

Scientific Experts

  • Shu ichi Okamoto
  • Hung Ying Kao
  • S V Subramanian
  • Nicola J A Scott
  • S Ferrari
  • Eric N Olson
  • Rhonda Bassel-Duby
  • Francisco J Naya
  • James A Richardson
  • Christine M Snyder
  • Ning Liu
  • Elizabeth P Ewen
  • David P Sparling
  • E N Olson
  • Christopher W Cowan
  • Kimberly M Huber
  • John McAnally
  • Michael A Arnold
  • Matthew J Potthoff
  • Tong Zang
  • Christina J Cole
  • Gisella Vetere
  • Graziella Messina
  • John M Shelton
  • Giulio Cossu
  • Michael P Czubryt
  • Sarah A McCalmon
  • Adam J Harrington
  • Bindu Ramachandran
  • Amanda L Clark
  • Xueying Chen
  • Caroline Daems
  • Ann Louise Olson
  • Beth A Griesel
  • Arnaud Obri
  • H Yuan
  • Ornella Cappellari
  • M G Dionyssiou
  • Niels Speksnijder
  • Charles Plessy
  • Hua She
  • Jiali Li
  • M Waseem Akhtar
  • Paul W Frankland
  • Marina A Maksimova
  • P Joel Ross
  • Sheena A Josselyn
  • Leonardo Restivo
  • Haojie Gong
  • Kuniko Nakajima
  • Hee Young Seok
  • Olivia Lenoir
  • Svetlana Bezprozvannaya
  • Brad E Pfeiffer
  • F Ishikawa
  • Aibin He
  • Soon Young Jung
  • William T Pu
  • Jinmi Choi
  • Xiaoxia Qi
  • Sadakatsu Ikeda
  • Joseph W Gordon
  • J Lu
  • Emmanuel Mukwevho
  • Xu Peng
  • Matthen Mathew
  • Jianzhong Zhao
  • John C McDermott
  • Kiyotoshi Satoh
  • Naohiro Yamaguchi
  • Olivier Leupin
  • Timothy A Bolger
  • J C McDermott
  • John J Andreucci
  • Yuri Kim
  • Tod Gulick
  • Jennifer T Durham
  • Aryaman Shalizi
  • Ralph J van Oort
  • Yasuyuki Ohkawa
  • Hsuan Ting Huang
  • Ondra M Brand
  • David L Allen
  • Steves Morin
  • Luciana De Angelis
  • T A McKinsey
  • Bangmin Zhu
  • Cyril Rauch
  • Hai Wu
  • Nikolai A Timchenko

Detail Information

Publications90

  1. ncbi Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo
    David L Allen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    J Biol Chem 280:17126-34. 2005
    ..Together, these data demonstrate that the quantitative differences in MyHC expression in mouse skeletal muscle have evolved at least in part through the elimination of positive-acting transcription factor binding sites...
  2. ncbi A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 311:1012-7. 2006
    ..We report here a requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex...
  3. ncbi Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Development 120:1251-63. 1994
    ..the control of muscle gene expression in vivo, we analyzed by in situ hybridization the expression patterns of the Mef2a, Mef2c and Mef2d genes during mouse embryogenesis. We first detected MEF2C expression at day 7.5 postcoitum (p.c...
  4. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs...
  5. ncbi Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
    G E Lyons
    Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA
    J Neurosci 15:5727-38. 1995
    ..The four MEF2 genes, Mef2A, -B, -C, -D, encode transcription factors belonging to the MADS (MCM1-agamous-deficiens-serum response factor) ..
  6. pmc Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 117:2459-67. 2007
    ..These findings provide what we believe are new insights into the molecular basis of skeletal muscle function and have important implications for possible therapeutic interventions into muscular diseases...
  7. pmc Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2
    Brad E Pfeiffer
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 66:191-7. 2010
    ..Our results reveal that active MEF2 and FMRP function together in an acute, cell-autonomous mechanism to eliminate excitatory synapses...
  8. ncbi Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor
    Francisco J Naya
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Med 8:1303-9. 2002
    The four MEF2 transcription factors (MEF2A, -B, -C, and -D) regulate differentiation and calcium-dependent gene expression in muscle cells...
  9. ncbi The expression of MEF2 genes is implicated in CNS neuronal differentiation
    X Lin
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore 21201, USA
    Brain Res Mol Brain Res 42:307-16. 1996
    ..In the developing postnatal cerebellum, RNA blot analysis revealed that MEF2A and MEF2D RNA levels increase after birth...
  10. pmc In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival
    M Waseem Akhtar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e34863. 2012
    ..to understand specific as well as redundant roles of the MEF2 isoforms, we generated brain-specific deletion of MEF2A and found that Mef2aKO mice show normal behavior in a range of paradigms including learning and memory...
  11. pmc Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
    Q Lin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Science 276:1404-7. 1997
    ..Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development...
  12. pmc Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Nature 408:106-11. 2000
    ....
  13. pmc MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders
    Adam J Harrington
    Department of Neurosciences, Medical University of South Carolina, Charleston, United States
    elife 5:. 2016
    ....
  14. doi MEF2A binding to the Glut4 promoter occurs via an AMPKα2-dependent mechanism
    Haojie Gong
    Beijing Sport University, Beijing, China
    Med Sci Sports Exerc 43:1441-50. 2011
    The role of AMP-activated protein kinase α2 (AMPKα2) in regulating MEF2A nucleus translocation, nuclear histone deacetylase 5 (HDAC5) association with MEF2, HDAC5 nuclear export, MEF2A binding to the Glut4 promoter, and GLUT4 ..
  15. pmc The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle
    Elizabeth P Ewen
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:29644-53. 2011
    ..Characterization of Mef2A knock-out mice has revealed severe myofibrillar defects in cardiac muscle indicating a requirement for Mef2A in ..
  16. pmc Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9
    Olivia Lenoir
    Institut National de la Sante et de la Recherche Medicale, U845, Research Center Growth and Signalling, Paris Descartes University, Sorbonne Paris Cité, Necker Hospital, Paris, France
    Diabetes 60:2861-71. 2011
    ..Previously, we showed that HDAC inhibitors modify the timing and determination of pancreatic cell fate. The aim of this study was to determine the role of class IIa HDACs in pancreas development...
  17. doi Inhibition of MEF2A prevents hyperglycemia-induced extracellular matrix accumulation by blocking Akt and TGF-β1/Smad activation in cardiac fibroblasts
    Xueying Chen
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
    Int J Biochem Cell Biol 69:52-61. 2015
    Myocyte enhancer factor 2A (MEF2A) functions in muscle-specific and/or growth factor-related transcription and is involved in cell growth, survival, and apoptosis...
  18. ncbi MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression
    Y Katoh
    Section of Molecular Cardiology, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 273:1511-8. 1998
    ..from smooth muscle nuclear extract reacts with MEF2B-specific antibody, but not with antibodies specific to MEF2A, MEF2C, or MEF2D, suggesting that only MEF2B protein binds to the A/T-rich element...
  19. pmc MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2
    Amanda L Clark
    From the Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, Massachusetts 02215
    J Biol Chem 290:23162-72. 2015
    ..demonstrated previously that microRNAs encoded by the Gtl2-Dio3 noncoding RNA locus function downstream of the MEF2A transcription factor in skeletal muscle regeneration...
  20. doi Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle
    H Yuan
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
    Acta Physiol (Oxf) 212:283-92. 2014
    ..A myocyte-specific enhancer factor (MEF2) site that binds MEF2A in the promoter of Cpt1b has been identified...
  21. pmc S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death
    Shu ichi Okamoto
    Neuroscience and Aging Research Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA Electronic address
    Cell Rep 8:217-28. 2014
    ..Our data define a molecular switch whereby redox-mediated posttranslational modification controls both neurogenesis and neurodegeneration via a single transcriptional signaling cascade...
  22. ncbi An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression
    R S Ross
    Department of Medicine, Center for Molecular Genetics, University of California, San Diego, School of Medicine, La Jolla 92093, USA
    Development 122:1799-809. 1996
    ..The patterned expression of this transgene may provide a model system in which to investigate the cues that dictate anterior-posterior (right ventricle/left ventricle) gradients during mammalian heart development...
  23. pmc Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity
    Tong Zang
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Cell Neurosci 56:39-49. 2013
    ..Our findings suggest that FMRP and MEF2 function together to fine tune synapse formation and elimination rates in response to neuronal activity levels over the course of postnatal development. ..
  24. pmc Requirement of MEF2A, C, and D for skeletal muscle regeneration
    Ning Liu
    Departments of Molecular Biology, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390
    Proc Natl Acad Sci U S A 111:4109-14. 2014
    ..To investigate the potential involvement of MEF2 factors in muscle regeneration, we conditionally deleted the Mef2a, c, and d genes, singly and in combination, within satellite cells in mice, using tamoxifen-inducible Cre ..
  25. doi MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1
    Caroline Daems
    Reproduction, Mother and Child Health C D, L J M, C B, J J T, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada, G1V 4G2 and Centre de Recherche en Biologie de la Reproduction J J T, Department of Obstetrics, Gynecology, and Reproduction, Faculty of Medicine, Universite Laval, Quebec City, Quebec, Canada, G1V 0A6
    Mol Endocrinol 28:886-98. 2014
    ..MEF2 was also positioned upstream of NR4A1 in a regulatory cascade controlling Leydig cell gene expression...
  26. pmc HDAC4 integrates PTH and sympathetic signaling in osteoblasts
    Arnaud Obri
    Department of Genetics and Development, Columbia University, New York, NY 10032
    J Cell Biol 205:771-80. 2014
    ..In this context, HDAC4 increases Rankl expression. Because of its ability to differentially connect two extracellular cues to the genome of osteoblasts, HDAC4 is a critical regulator of osteoclast differentiation. ..
  27. pmc Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel
    Naohiro Yamaguchi
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Invest 117:1344-53. 2007
    ..Taken together, the data indicate that impaired CaM inhibition of RyR2, associated with defective sarcoplasmic reticulum Ca(2+) release and altered gene expression, leads to cardiac hypertrophy and early death...
  28. pmc MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration
    Christine M Snyder
    Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, MA 02215, USA
    Development 140:31-42. 2013
    ..Our data demonstrate that the MEF2A transcription factor plays an essential role in skeletal muscle regeneration in adult mice...
  29. ncbi The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2
    Timothy A Bolger
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 282:29186-92. 2007
    ..Our results identify the MEF2-HDAC4 complex as a target for ataxin-1 transcriptional repression activity and suggest a novel pathogenic mechanism whereby ataxin-1 sequesters and inhibits the neuronal survival factor MEF2...
  30. pmc Promoter architecture of mouse olfactory receptor genes
    Charles Plessy
    RIKEN Yokohama Institute, Omics Science Center, Yokohama, Kanagawa, Japan
    Genome Res 22:486-97. 2012
    ..OR gene expression and among them confirmed by chromatin immunoprecipitation the binding of TBP, EBF1 (OLF1), and MEF2A to OR promoters...
  31. pmc Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
    Jiali Li
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey, USA
    Nat Med 18:783-90. 2012
    ..Nuclear HDAC4 binds to chromatin, as well as to myocyte enhancer factor 2A (MEF2A) and cAMP-responsive element binding protein (CREB), leading to histone deacetylation and altered neuronal gene ..
  32. doi Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory
    Ornella Cappellari
    Department of Cell and Developmental Biology and Centre for Stem Cells and Regenerative Medicine, University College London, WC1E 6DE London, UK
    Dev Cell 24:586-99. 2013
    ..Myf5-expressing cells adopt a perithelial position, as occasionally also observed in wild-type (WT) embryos. These data indicate that endothelium, via Dll4 and PDGF-BB, induces a fate switch in adjacent skeletal myoblasts...
  33. pmc Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-JUN in a neuronal context
    Niels Speksnijder
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University Medical Center, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Mol Neurosci 48:209-18. 2012
    ..At the same time, GR influences MEF2 activity and DNA binding. These results give novel insight into the molecular interplay of GR and MEF2 in the control of genes important for neuronal plasticity...
  34. pmc Neurotoxin-induced selective ubiquitination and regulation of MEF2A isoform in neuronal stress response
    Hua She
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA
    J Neurochem 122:1203-10. 2012
    ..Whether stress signal may differentially regulate MEF2s remains largely unknown. In this work, we showed that MEF2A, but not MEF2C or MEF2D, was modified by ubiquitination in dopaminergic neuronal cell line SN4741 cells...
  35. doi MEF2 negatively regulates learning-induced structural plasticity and memory formation
    Christina J Cole
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Neurosci 15:1255-64. 2012
    ..These bidirectional effects indicate that MEF2 is a key regulator of plasticity and that relieving the suppressive effects of MEF2-mediated transcription permits memory formation...
  36. doi Cross-talk between glycogen synthase kinase 3β (GSK3β) and p38MAPK regulates myocyte enhancer factor 2 (MEF2) activity in skeletal and cardiac muscle
    M G Dionyssiou
    Department of Biology, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    J Mol Cell Cardiol 54:35-44. 2013
    ..Pharmacological inhibition of GSK3β resulted in enhanced MEF2A/D expression and transcriptional activity in skeletal myoblasts and cardiac myocytes...
  37. ncbi Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain
    Bangmin Zhu
    Diabetes Research Laboratory, Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:28749-60. 2005
    ..In vertebrate MEF2A, -C, and -D, a splice versus no-splice option gives forms that include or exclude a short domain that we designate ..
  38. ncbi Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23
    G M Hobson
    Department of Medical Cell Biology, Alfred I duPont Institute, Wilmington, Delaware 19899, USA
    Genomics 29:704-11. 1995
    ..MEF2 cDNA clones suggests that they arose from alternatively spliced transcripts of four different genes, termed MEF2A-D...
  39. ncbi Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis
    S V Subramanian
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Mech Dev 57:103-12. 1996
    ..However, MEF2A and MEF2D transcripts have been detected in many adult tissues where they are not translated or the corresponding ..
  40. ncbi Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family
    B L Black
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 271:26659-63. 1996
    ..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins...
  41. ncbi Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Biol Chem 278:21998-2005. 2003
    ..Together these data provide the first evidence that BMP-2-induced PI 3-kinase signaling regulates MEF-2A expression and define a mechanism of MEF-2A-dependent BMP-2 transcription...
  42. pmc Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
    J Lu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Proc Natl Acad Sci U S A 97:4070-5. 2000
    ....
  43. pmc Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A
    John B Knight
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Room 853 BMSB, Oklahoma City, OK 73190, USA
    Proc Natl Acad Sci U S A 100:14725-30. 2003
    ..The MEF2 domain binds transcription factors MEF2A and MEF2D in vivo. Domain I binds a transcription factor, GLUT4 enhancer factor (GEF)...
  44. doi TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2
    Soon Young Jung
    College of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Biochem Biophys Res Commun 396:238-45. 2010
    ..Taken together all these data, we concluded that the synergism of MyoD (or myogenin) and MEF2 is necessary for TRIM72 expression during C2C12 differentiation...
  45. doi Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors
    Jinmi Choi
    National Research Laboratory for Metabolic Checkpoint, Departments of Biomedical Sciences and Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Biochem Biophys Res Commun 401:327-32. 2010
    ..Altogether, the present study suggests a de-repression model and expands the understanding on the dynamic regulation of chromatin during myogenesis...
  46. ncbi Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle
    Horacio Moreno
    Parc Científic de Barcelona and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    J Biol Chem 278:40557-64. 2003
    ..Different MEF2 isoforms expressed in skeletal muscle (MEF2A, MEF2C, and MEF2D) and all members of the MyoD family had the capacity to participate in the activity of the GLUT4 ..
  47. doi Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
    Kuniko Nakajima
    Mitsubishi Kagaku Institute of Life Sciences, Machida 194 8511, Japan
    Development 138:1771-82. 2011
    ..Thus, a Jmj-cyclin D1 pathway coordinately regulates proliferation and differentiation of cardiomyocytes...
  48. pmc Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory
    Gisella Vetere
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 108:8456-60. 2011
    ..Together, these data strengthen the causal link between cortical structural remodeling and memory consolidation and, further, identify MEF2 as a key regulator of these processes...
  49. ncbi Calcineurin initiates skeletal muscle differentiation by activating MEF2 and MyoD
    Bret B Friday
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Building, Atlanta, GA 30322, USA
    Differentiation 71:217-27. 2003
    ..These results demonstrate that calcineurin regulates skeletal muscle differentiation by activating MEF2 and MyoD transcription factors leading to the induction of myogenin expression...
  50. pmc miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation
    Hee Young Seok
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 286:35339-46. 2011
    ..b>MEF2A is a member of the MEF2 (myogenic enhancer factor 2) family of transcription factors...
  51. pmc Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation
    Jean Bernard Lazaro
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1792-805. 2002
    ....
  52. ncbi The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4
    Susan Gray
    Cardiovascular Division, Brigham and Women s Hospital, Thorn Building, 20 Shattuck Street, Boston, MA 02115, USA
    J Biol Chem 277:34322-8. 2002
    ..00001) glucose uptake are increased in KLF15-overexpressing adipocytes. In co-transfection assays, KLF15 and MEF2A, a known activator of GLUT4, synergistically activates the GLUT4 promoter...
  53. ncbi Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation
    Xue Q Gong
    Department of Internal Medicine and the Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 277:12310-7. 2002
    ..Together, these results suggest that MEF2 is an important target in Dermo-1-mediated transcriptional repression and provide initial evidence of the involvement of histone acetylation in Dermo-1 transcriptional repression...
  54. ncbi Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7
    H Y Kao
    Department of Biochemistry, School of Medicine, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Biol Chem 276:47496-507. 2001
    ..a member of the class II histone deacetylases, specifically targets several members of myocyte enhancer factors, MEF2A, -2C, and -2D, and inhibits their transcriptional activity...
  55. pmc Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins
    Z A Quinn
    Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada
    Nucleic Acids Res 29:732-42. 2001
    ..We have also observed in vivo interactions between Smad2 and MEF2A using co-immunoprecipitation assays...
  56. ncbi Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene
    F J Naya
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75235 9148, USA
    Development 126:2045-52. 1999
    ..The discordance between MEF2 mRNA expression and MEF2 transcriptional activity in nonmuscle cell types of embryos and adults also supports the notion that post-transcriptional mechanisms regulate the expression of MEF2 proteins...
  57. ncbi Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo
    R Di Lisi
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    J Biol Chem 273:25371-80. 1998
    ..A mutation that blocks this binding markedly reduces gene activation in vivo and in vitro, and overexpression of MEF2A, MEF2C, and MEF2D in noncardiac cells transactivates the cardiac troponin I promoter...
  58. pmc The MEF2A 3' untranslated region functions as a cis-acting translational repressor
    B L Black
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center, Dallas 75235, USA
    Mol Cell Biol 17:2756-63. 1997
    ..In an effort to identify sequences within the MEF2A message which control translation, we isolated the mouse MEF2A 3' untranslated region (UTR) and fused it to the ..
  59. ncbi Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle
    S Ferrari
    Dipartimento di Scienze Biomediche, Universita di Modena, Italy
    Cell Growth Differ 8:23-34. 1997
    ..We propose that phosphorylation of MEF2 regulates its activity and represents an important aspect of the mechanism controlling stage-specific transcription during skeletal myogenesis...
  60. ncbi Role of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in the development of an acute neutrophil inflammatory response in mice
    D Metcalf
    Walter and Eliza Hall Institute of Medical Research, Ludwig, Victoria, Australia
    Blood 88:3755-64. 1996
    ..Typical eosinophil inflammatory responses to the injection of casein or thioglycollate occurred in GM-CSF -/ -mice but not in beta c -/- mice, suggesting that interleukin-5 was necessary for this response...
  61. pmc A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing
    J F Martin
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 14:1647-56. 1994
    ..The complexity of the MEF2 family of regulatory proteins provides the potential for fine-tuning of transcriptional responses as a consequence of combinatorial interactions among multiple MEF2 isoforms encoded by the four Mef2 genes...
  62. pmc Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter
    I Komuro
    Molecular Medicine Division, Beth Israel Hospital, Boston, MA
    EMBO J 12:1387-401. 1993
    ..Although the true biological role of Gtx is not known, these results suggest that Gtx is a novel cell-type specific homeobox gene that has the potential to act as a transcriptional repressor for a subset of serum-inducible genes...
  63. ncbi The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells
    K Hidaka
    Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 213:555-60. 1995
    ..At least three different MADS/MEF2 domains (MEF2A, 2B and 2D) were isolated from P19 cells with the MOPAC technique (mixed oligonucleotides primed amplification of ..
  64. pmc Regulation of cardiomyocyte Glut4 expression by ZAC1
    Michael P Czubryt
    Department of Physiology, University of Manitoba, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Winnipeg, Manitoba R2H 2A6, Canada
    J Biol Chem 285:16942-50. 2010
    ..This work identifies ZAC1 as a novel and previously unknown regulator of cardiomyocyte Glut4 expression and glucose uptake. Our results also implicate MEF2 as a regulator of ZAC1 expression in response to induction of hypertrophy...
  65. ncbi Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein
    Jennifer T Durham
    Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 281:6841-9. 2006
    ..Here, we describe the characterization of a direct, downstream target gene for the MEF2A transcription factor encoding a large, muscle-specific protein that localizes to the costamere in striated muscle...
  66. pmc Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1
    Yasuyuki Ohkawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    EMBO J 25:490-501. 2006
    ....
  67. ncbi MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure
    Ralph J van Oort
    Hubrecht Laboratory, and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, Netherlands
    Circulation 114:298-308. 2006
    ..Although the transcription factor myocyte enhancer factor-2 (MEF2) is a common end point for several hypertrophic pathways, its precise cardiac gene targets and function in cardiac remodeling remain to be elucidated...
  68. ncbi Hyperphosphorylation of MEF2A in primary adipocytes correlates with downregulation of human GLUT4 gene promoter activity
    David P Sparling
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, PO Box 26901, Rm 853 BMSB, Oklahoma City, OK 73190, USA
    Am J Physiol Endocrinol Metab 292:E1149-56. 2007
    ..model systems are compared can be correlated to a posttranslational phosphorylation of the transcription factor MEF2A. The difference in the MEF2A phosphorylation state in whole tissue vs...
  69. ncbi Identification of MEF2-regulated genes during muscle differentiation
    James Paris
    Microarray Centre, Clinical Genomics Centre, University Health Network, Toronto, Ontario, Canada
    Physiol Genomics 20:143-51. 2004
    ..The results of this study provides for the first time, a unique look at gene regulation at the level of transcription factor binding in differentiating muscle...
  70. ncbi Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart
    Marguerite Lemonnier
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:55651-8. 2004
    ..This site binds myocyte enhancer factor (MEF)2 factors, principally MEF2D and MEF2A in cardiocyte nuclear extracts...
  71. ncbi Static stretch promotes MEF2A nuclear translocation and expression of neonatal myosin heavy chain in C2C12 myocytes in a calcineurin- and p38-dependent manner
    Cyril Rauch
    Muscle and Molecular Biology Unit, Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, Royal College St, London NW1 0TU, United Kingdom
    Am J Physiol Cell Physiol 288:C593-605. 2005
    ..In the present study, the effect of static stretch on the activation of transcriptional factors MEF2A and NFATc1, which have been shown to be involved in the differentiation and phenotype regulation of skeletal ..
  72. pmc Control of the SOST bone enhancer by PTH using MEF2 transcription factors
    Olivier Leupin
    Bone and Cartilage Unit, Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland
    J Bone Miner Res 22:1957-67. 2007
    ..Expression of the osteocyte-derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors control this enhancer and mediate inhibition of sclerostin expression by PTH...
  73. pmc Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development
    Kiyotoshi Satoh
    Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda, Tokyo 101 0062, Japan
    Mol Cell Biol 27:7623-30. 2007
    ..In the present study, we identified the transcription factor myocyte enhancer factor 2A (MEF2A) as a novel substrate for NLK...
  74. ncbi Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis
    Nikolai A Timchenko
    Department of Pathology and Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 279:13129-39. 2004
    ..Our data demonstrate that the elevation of CUGBP1 in skeletal muscle causes overexpression of MEF2A and p21 to levels that are significantly higher than those in skeletal muscle of wild type animals...
  75. pmc Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell Biol 27:8143-51. 2007
    ..In contrast, neither Mef2a nor Mef2d is required for normal skeletal muscle development in vivo...
  76. pmc An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
    Ning Liu
    Departments of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 104:20844-9. 2007
    ....
  77. doi Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism
    Emmanuel Mukwevho
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Dept of Human Biology, Univ of Cape Town, Cape Town 7700, South Africa, P O Box 115, Newlands, 7725, South Africa
    Am J Physiol Endocrinol Metab 294:E582-8. 2008
    ..05) and increased the amount of MEF2A that was bound to this site approximately 2.2-fold (P < 0.05) 4 h posttreatment compared with controls...
  78. pmc GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes
    David P Sparling
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Biol Chem 283:7429-37. 2008
    ..to understand this important process, we have characterized GEF structural domains and its interactions with the MEF2A isoform...
  79. pmc Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits
    Bindu Ramachandran
    Diabetes Research Laboratory, Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:11935-46. 2008
    ..We show that MEF2A mRNA is induced with forced expression of NRF1 and that the MEF2A 5'-regulatory region contains an evolutionarily ..
  80. pmc Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice
    Xu Peng
    Departments of Molecular Medicine, Clinical Sciences, and Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 105:6638-43. 2008
    ..Microarray analysis suggests that myocyte enhancer factor 2a (MEF2a) can be regulated by FAK and that inactivation of FAK in the embryonic heart compromised MEF2a expression...
  81. pmc MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes
    Sadakatsu Ikeda
    Department of Cardiology, Children s Hospital Boston, Department of Genetics, Harvard Medical School, Boston, Massachusetts 021151, USA
    Mol Cell Biol 29:2193-204. 2009
    ..miR-1 also negatively regulated the expression of Mef2a and Gata4, key transcription factors that mediate calcium-dependent changes in gene expression...
  82. pmc Protein kinase A-regulated assembly of a MEF2{middle dot}HDAC4 repressor complex controls c-Jun expression in vascular smooth muscle cells
    Joseph W Gordon
    Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada
    J Biol Chem 284:19027-42. 2009
    ..Regulation of this molecular "switch" on the c-jun promoter may thus prove critical for toggling between the activated and quiescent VSMC phenotypes...
  83. pmc Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development
    Nicola J A Scott
    Department of Medicine, University of Otago Christchurch, P O Box 4345, Christchurch, New Zealand
    Biochim Biophys Acta 1792:1175-84. 2009
    ..wild-type (WT) mice, but no concomitant increase in expression of the hypertrophy-related transcription factors, Mef2A, Mef2C, GATA-4, GATA-6 or serum response factor (SRF)...
  84. doi Transcriptional induction of MMP-10 by TGF-beta, mediated by activation of MEF2A and downregulation of class IIa HDACs
    F Ishikawa
    Department of Cancer Cell Biology, Showa University School of Pharmacy, Tokyo, Japan
    Oncogene 29:909-19. 2010
    ..TGF-beta upregulated the gene promoter through the MEF2 site, and knockdown of the MEF2A transcription factor negatively affected MMP-10 induction, whereas its overexpression had a positive effect on the ..
  85. pmc Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2
    Sarah A McCalmon
    Department of Biology, Boston University, 24 Cummington st, Boston, MA 02215, USA
    Circ Res 106:952-60. 2010
    ..The vasoactive peptide angiotensin II (Ang II) is a potent cardiotoxic hormone whose actions have been well studied, yet questions remain pertaining to the downstream factors that mediate its effects in cardiomyocytes...
  86. doi Nfix regulates fetal-specific transcription in developing skeletal muscle
    Graziella Messina
    San Raffaele Scientific Institute, Milan, Italy
    Cell 140:554-66. 2010
    ..In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-..
  87. ncbi Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway
    Luciana De Angelis
    Istituto di Istologia ed Embriologia Generale, Universita di Roma La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
    Dev Biol 283:171-9. 2005
    ..We document expression of MEF2A and p38 MAPK proteins in the somite of 9.5 dpc mouse embryos concurrent with Myf 5 protein expression...
  88. ncbi Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein
    Hsuan Ting Huang
    Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 281:39370-9. 2006
    ..In our continuing effort to identify novel, downstream pathways controlled by MEF2, we have used mef2a knock-out mice to find those genes dependent on MEF2A transcriptional activity...
  89. ncbi Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes
    Y Qiu
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 29:240-6. 1995
    ..Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP-TF genes are located in chromosomal regions that are syntenic between mouse and human...
  90. ncbi MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters
    Steves Morin
    Laboratory of Cardiac Growth and Differentiation, Institut de recherches cliniques de Montreal IRCM, Quebec, Canada
    J Biol Chem 280:32272-8. 2005
    ..These findings identify a novel mechanism for HAND action in the heart and provide a general paradigm to understand the mechanism of HAND action in organogenesis...

Research Grants1

  1. Regulation of histone deacetylase 7 (HDAC7) activity
    Hung Ying Kao; Fiscal Year: 2006
    ..Understanding how cellular signaling controls HDAC activities will help to understand deregulated cell growth in cancer and may have therapeutic implications for cancer treatment. ..